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Aliases for GMFB Gene

Aliases for GMFB Gene

  • Glia Maturation Factor Beta 2 3 5
  • GMF-Beta 3 4
  • GMF 3

External Ids for GMFB Gene

Previous GeneCards Identifiers for GMFB Gene

  • GC14M052265
  • GC14M048737
  • GC14M052931
  • GC14M054010
  • GC14M054941
  • GC14M035103

Summaries for GMFB Gene

GeneCards Summary for GMFB Gene

GMFB (Glia Maturation Factor Beta) is a Protein Coding gene. Among its related pathways are Signal transduction_Erk Interactions- Inhibition of Erk and Development Angiotensin activation of ERK. GO annotations related to this gene include actin binding and growth factor activity. An important paralog of this gene is GMFG.

UniProtKB/Swiss-Prot for GMFB Gene

  • This protein causes differentiation of brain cells, stimulation of neural regeneration, and inhibition of proliferation of tumor cells.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GMFB Gene

Genomics for GMFB Gene

Regulatory Elements for GMFB Gene

Enhancers for GMFB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F054502 1.4 FANTOM5 Ensembl ENCODE 8.7 -14.0 -14025 1.6 SOX13 CTCF PKNOX1 TAL1 CEBPG RAD21 TEAD3 SLC30A9 NCOR1 SMC3 GCH1 GMFB CGRRF1
GH14F054497 0.9 ENCODE 7.1 -8.9 -8910 1.8 ELF3 ATF1 ARID4B RARA CREM MIXL1 THAP11 HMG20B KAT8 KLF16 CNIH1 GMFB CGRRF1
GH14F054450 1.4 FANTOM5 Ensembl ENCODE 4.2 +38.0 37987 2.4 SOX13 TBP TFAP4 ESRRA PKNOX1 MAX CEBPG ZNF48 ZNF644 RARA GCH1 CNIH1 GMFB CGRRF1 ENSG00000258753
GH14F054908 1.1 FANTOM5 Ensembl ENCODE 4.3 -419.2 -419241 0.7 PKNOX1 IRF2 MTA2 PBX2 MLLT1 IRF1 GCH1 ATG14 GMFB LGALS3 FBXO34 MAPK1IP1L GC14P054912
GH14F054624 1.5 FANTOM5 Ensembl ENCODE 2.8 -138.2 -138183 6.0 FEZF1 BMI1 RAD21 ZNF2 ZNF335 ZNF366 SCRT2 ETV6 FOS ZNF263 GCH1 GMFB MAPK1IP1L SAMD4A LOC729451
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GMFB on UCSC Golden Path with GeneCards custom track

Promoters for GMFB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000097803 696 2201 HDGF PKNOX1 ARID4B SIN3A YBX1 DMAP1 ZNF2 YY1 ZNF207 NFYC

Genomic Location for GMFB Gene

Chromosome:
14
Start:
54,474,484 bp from pter
End:
54,489,196 bp from pter
Size:
14,713 bases
Orientation:
Minus strand

Genomic View for GMFB Gene

Genes around GMFB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GMFB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GMFB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GMFB Gene

Proteins for GMFB Gene

  • Protein details for GMFB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60983-GMFB_HUMAN
    Recommended name:
    Glia maturation factor beta
    Protein Accession:
    P60983
    Secondary Accessions:
    • B2R499
    • P17774
    • Q9BS35

    Protein attributes for GMFB Gene

    Size:
    142 amino acids
    Molecular mass:
    16713 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH05359.1; Type=Frameshift; Positions=142; Evidence={ECO:0000305}; Sequence=AAP35430.1; Type=Frameshift; Positions=142; Evidence={ECO:0000305};

neXtProt entry for GMFB Gene

Post-translational modifications for GMFB Gene

Other Protein References for GMFB Gene

Antibody Products

No data available for DME Specific Peptides for GMFB Gene

Domains & Families for GMFB Gene

Protein Domains for GMFB Gene

Suggested Antigen Peptide Sequences for GMFB Gene

Graphical View of Domain Structure for InterPro Entry

P60983

UniProtKB/Swiss-Prot:

GMFB_HUMAN :
  • Contains 1 ADF-H domain.
  • Belongs to the actin-binding proteins ADF family. GMF subfamily.
Domain:
  • Contains 1 ADF-H domain.
Family:
  • Belongs to the actin-binding proteins ADF family. GMF subfamily.
genes like me logo Genes that share domains with GMFB: view

No data available for Gene Families for GMFB Gene

Function for GMFB Gene

Molecular function for GMFB Gene

UniProtKB/Swiss-Prot Function:
This protein causes differentiation of brain cells, stimulation of neural regeneration, and inhibition of proliferation of tumor cells.

Gene Ontology (GO) - Molecular Function for GMFB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0004860 protein kinase inhibitor activity TAS 8639570
GO:0004871 signal transducer activity TAS 7598724
GO:0008047 enzyme activator activity TAS 8798479
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with GMFB: view
genes like me logo Genes that share phenotypes with GMFB: view

Animal Models for GMFB Gene

MGI Knock Outs for GMFB:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GMFB Gene

Localization for GMFB Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GMFB gene
Compartment Confidence
cytosol 3
nucleus 2
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for GMFB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with GMFB: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GMFB Gene

Pathways & Interactions for GMFB Gene

genes like me logo Genes that share pathways with GMFB: view

Pathways by source for GMFB Gene

Gene Ontology (GO) - Biological Process for GMFB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation TAS 7598724
GO:0006469 negative regulation of protein kinase activity IEA --
GO:0007165 signal transduction TAS 8798479
GO:0007399 nervous system development TAS 1712830
GO:0007612 learning IEA --
genes like me logo Genes that share ontologies with GMFB: view

No data available for SIGNOR curated interactions for GMFB Gene

Drugs & Compounds for GMFB Gene

(1) Additional Compounds for GMFB Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GMFB: view

Transcripts for GMFB Gene

Unigene Clusters for GMFB Gene

Glia maturation factor, beta:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GMFB Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e
SP1: - - -
SP2: - -
SP3: - - - -
SP4: - - - -
SP5: -
SP6: -

Relevant External Links for GMFB Gene

GeneLoc Exon Structure for
GMFB
ECgene alternative splicing isoforms for
GMFB

Expression for GMFB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GMFB Gene

mRNA differential expression in normal tissues according to GTEx for GMFB Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.4).

Protein differential expression in normal tissues from HIPED for GMFB Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GMFB Gene



Protein tissue co-expression partners for GMFB Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GMFB Gene:

GMFB

SOURCE GeneReport for Unigene cluster for GMFB Gene:

Hs.151413
genes like me logo Genes that share expression patterns with GMFB: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for GMFB Gene

Orthologs for GMFB Gene

This gene was present in the common ancestor of animals.

Orthologs for GMFB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GMFB 34 35
  • 99.53 (n)
dog
(Canis familiaris)
Mammalia GMFB 34 35
  • 96.48 (n)
cow
(Bos Taurus)
Mammalia GMFB 34 35
  • 95.77 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GMFB 35
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gmfb 34 16 35
  • 90.85 (n)
rat
(Rattus norvegicus)
Mammalia Gmfb 34
  • 90.14 (n)
oppossum
(Monodelphis domestica)
Mammalia GMFB 35
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves GMFB 34 35
  • 85.21 (n)
lizard
(Anolis carolinensis)
Reptilia GMFB 35
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gmfg 34
  • 80.28 (n)
Str.7359 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.24755 34
zebrafish
(Danio rerio)
Actinopterygii gmfb 34 35
  • 75.89 (n)
wufa97c03 34
fruit fly
(Drosophila melanogaster)
Insecta CG5869 34 35
  • 56.06 (n)
BG:DS02740.9 36
  • 53 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009059 34
  • 53.28 (n)
worm
(Caenorhabditis elegans)
Secernentea Y50D7A.10 35
  • 40 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 42 (a)
ManyToMany
-- 35
  • 37 (a)
ManyToMany
-- 35
  • 37 (a)
ManyToMany
Species where no ortholog for GMFB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GMFB Gene

ENSEMBL:
Gene Tree for GMFB (if available)
TreeFam:
Gene Tree for GMFB (if available)

Paralogs for GMFB Gene

Paralogs for GMFB Gene

(1) SIMAP similar genes for GMFB Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for GMFB Gene

genes like me logo Genes that share paralogs with GMFB: view

Variants for GMFB Gene

Sequence variations from dbSNP and Humsavar for GMFB Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs10139223 -- 54,480,192(+) GATGA(C/G)TAAAA intron-variant
rs111294485 -- 54,487,089(+) AAATA(C/T)TGAAA intron-variant
rs111309722 -- 54,474,121(+) TTGTC(A/C)ATGGG downstream-variant-500B
rs1113205 -- 54,480,304(+) ATATT(G/T)TGAGT intron-variant
rs111782934 -- 54,479,567(+) TTTGA(A/G)TGTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GMFB Gene

Variant ID Type Subtype PubMed ID
nsv819843 CNV loss 19587683
nsv832802 CNV loss 17160897

Variation tolerance for GMFB Gene

Residual Variation Intolerance Score: 44% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.22; 4.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GMFB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GMFB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GMFB Gene

Disorders for GMFB Gene

Relevant External Links for GMFB

Genetic Association Database (GAD)
GMFB
Human Genome Epidemiology (HuGE) Navigator
GMFB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GMFB

No disorders were found for GMFB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GMFB Gene

Publications for GMFB Gene

  1. Molecular cloning and expression of biologically active human glia maturation factor-beta. (PMID: 1712830) Kaplan R. … Lim R. (J. Neurochem. 1991) 2 3 4 22 64
  2. Phorbol ester stimulates rapid intracellular phosphorylation of glia maturation factor. (PMID: 7598724) Lim R. … Zaheer A. (Biochem. Biophys. Res. Commun. 1995) 3 4 22 64
  3. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PMID: 19086053) GratacA^s M. … Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 46 64
  4. [Effect of glia maturation factor beta on the activation of hepatic stellate cells and on liver fibrosis]. (PMID: 18171522) Rao H.Y. … Wei L. (Zhonghua Gan Zang Bing Za Zhi 2007) 3 22 64
  5. Glia maturation factor-beta is produced by thymoma and may promote intratumoral T-cell differentiation. (PMID: 16115230) Yamazaki H. … Eimoto T. (Histopathology 2005) 3 22 64

Products for GMFB Gene

Sources for GMFB Gene

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