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Aliases for GMEB1 Gene

Aliases for GMEB1 Gene

  • Glucocorticoid Modulatory Element Binding Protein 1 2 3
  • Parvovirus Initiation Factor P96 3 4
  • DNA-Binding Protein P96PIF 3 4
  • PIF P96 3 4
  • GMEB-1 3 4
  • P96PIF 3
  • PIF96 3

External Ids for GMEB1 Gene

Previous GeneCards Identifiers for GMEB1 Gene

  • GC01P029001
  • GC01P028160
  • GC01P028500
  • GC01P028815
  • GC01P028867
  • GC01P027247

Summaries for GMEB1 Gene

Entrez Gene Summary for GMEB1 Gene

  • This gene encodes a member of KDWK gene family which associates with GMEB2 protein. The GMEB1-GMEB2 complex is essential for parvovirus DNA replication. Studies in rat for a similar gene suggest that this gene's role is to modulate the transactivation of the glucocorticoid receptor when it is bound to glucocorticoid response elements. Two alternative spliced transcript variants encoding different isoforms exist. [provided by RefSeq, Feb 2011]

GeneCards Summary for GMEB1 Gene

GMEB1 (Glucocorticoid Modulatory Element Binding Protein 1) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription coactivator activity. An important paralog of this gene is GMEB2.

UniProtKB/Swiss-Prot for GMEB1 Gene

  • Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses

Gene Wiki entry for GMEB1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GMEB1 Gene

Genomics for GMEB1 Gene

Regulatory Elements for GMEB1 Gene

Transcription factor binding sites by QIAGEN in the GMEB1 gene promoter:

Genomic Location for GMEB1 Gene

Chromosome:
1
Start:
28,668,722 bp from pter
End:
28,719,353 bp from pter
Size:
50,632 bases
Orientation:
Plus strand

Genomic View for GMEB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GMEB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GMEB1 Gene

Proteins for GMEB1 Gene

  • Protein details for GMEB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y692-GMEB1_HUMAN
    Recommended name:
    Glucocorticoid modulatory element-binding protein 1
    Protein Accession:
    Q9Y692
    Secondary Accessions:
    • B1AT48
    • Q9NWH1
    • Q9UKD0

    Protein attributes for GMEB1 Gene

    Size:
    573 amino acids
    Molecular mass:
    62591 Da
    Quaternary structure:
    • Homodimer, and heterodimer of GMEB1 and GMEB2. GMEB1 and GMEB2 form the parvovirus initiator complex (PIF). Interacts with the glucocorticoid receptor (NR3C1) and NCOA2/TIF2 (By similarity). May interact with HSP27 and CREB-binding protein (CBP).

    Three dimensional structures from OCA and Proteopedia for GMEB1 Gene

    Alternative splice isoforms for GMEB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GMEB1 Gene

Proteomics data for GMEB1 Gene at MOPED

Post-translational modifications for GMEB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GMEB1 Gene

Antibody Products

No data available for DME Specific Peptides for GMEB1 Gene

Domains & Families for GMEB1 Gene

Protein Domains for GMEB1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y692

UniProtKB/Swiss-Prot:

GMEB1_HUMAN :
  • Contains 1 SAND domain.
Domain:
  • Contains 1 SAND domain.
genes like me logo Genes that share domains with GMEB1: view

No data available for Gene Families for GMEB1 Gene

Function for GMEB1 Gene

Molecular function for GMEB1 Gene

UniProtKB/Swiss-Prot Function:
Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses

Gene Ontology (GO) - Molecular Function for GMEB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IBA --
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA --
GO:0003677 DNA binding --
GO:0003700 transcription factor activity, sequence-specific DNA binding --
GO:0003713 transcription coactivator activity IEA --
genes like me logo Genes that share ontologies with GMEB1: view
genes like me logo Genes that share phenotypes with GMEB1: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GMEB1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for GMEB1 Gene

Localization for GMEB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GMEB1 Gene

Nucleus. Cytoplasm. Note=May be also cytoplasmic.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GMEB1 Gene COMPARTMENTS Subcellular localization image for GMEB1 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for GMEB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 10386584
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with GMEB1: view

Pathways & Interactions for GMEB1 Gene

SuperPathways for GMEB1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GMEB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with GMEB1: view

No data available for Pathways by source and SIGNOR curated interactions for GMEB1 Gene

Drugs & Compounds for GMEB1 Gene

No Compound Related Data Available

Transcripts for GMEB1 Gene

Unigene Clusters for GMEB1 Gene

Glucocorticoid modulatory element binding protein 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GMEB1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GMEB1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: -
SP2: -
SP3:

Relevant External Links for GMEB1 Gene

GeneLoc Exon Structure for
GMEB1
ECgene alternative splicing isoforms for
GMEB1

Expression for GMEB1 Gene

mRNA expression in normal human tissues for GMEB1 Gene

Protein differential expression in normal tissues from HIPED for GMEB1 Gene

This gene is overexpressed in Pancreas (23.0), Peripheral blood mononuclear cells (10.1), NK cells (7.6), CD8 Tcells (7.2), and Monocytes (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GMEB1 Gene



SOURCE GeneReport for Unigene cluster for GMEB1 Gene Hs.632373

genes like me logo Genes that share expression patterns with GMEB1: view

Protein tissue co-expression partners for GMEB1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GMEB1 Gene

Orthologs for GMEB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GMEB1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GMEB1 35
  • 95.15 (n)
  • 98.93 (a)
GMEB1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GMEB1 35
  • 95.09 (n)
  • 98.93 (a)
GMEB1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gmeb1 35
  • 89.38 (n)
  • 95.2 (a)
Gmeb1 16
Gmeb1 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GMEB1 35
  • 99.83 (n)
  • 99.83 (a)
GMEB1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gmeb1 35
  • 88.79 (n)
  • 95.55 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 93 (a)
OneToMany
-- 36
  • 75 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia GMEB1 36
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves GMEB1 35
  • 80.15 (n)
  • 87.7 (a)
GMEB1 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GMEB1 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gmeb1 35
  • 66.33 (n)
  • 66.33 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.23484 35
zebrafish
(Danio rerio)
Actinopterygii gmeb1 35
  • 60.44 (n)
  • 55.62 (a)
gmeb1 36
  • 45 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea gmeb-1 36
  • 23 (a)
ManyToMany
gmeb-2 36
  • 16 (a)
ManyToMany
gmeb-3 36
  • 19 (a)
ManyToMany
spe-44 36
  • 16 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9551 36
  • 24 (a)
OneToMany
Species with no ortholog for GMEB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GMEB1 Gene

ENSEMBL:
Gene Tree for GMEB1 (if available)
TreeFam:
Gene Tree for GMEB1 (if available)

Paralogs for GMEB1 Gene

Paralogs for GMEB1 Gene

(1) SIMAP similar genes for GMEB1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GMEB1: view

Variants for GMEB1 Gene

Sequence variations from dbSNP and Humsavar for GMEB1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2306476 -- 28,702,402(-) TGAAT(G/T)TAACG intron-variant
rs2318373 -- 28,708,355(+) gaggc(A/G)gggtt intron-variant
rs2318376 -- 28,700,664(+) TGGGC(A/G)ACAAA intron-variant
rs3214953 -- 28,710,770(+) AAAAA(-/A)GCCGC intron-variant
rs4233252 -- 28,706,086(+) gaggc(A/G)gaaca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GMEB1 Gene

Variant ID Type Subtype PubMed ID
esv27154 CNV Loss 19812545

Variation tolerance for GMEB1 Gene

Residual Variation Intolerance Score: 12.19% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.93; 19.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GMEB1 Gene

HapMap Linkage Disequilibrium report
GMEB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GMEB1 Gene

Disorders for GMEB1 Gene

Relevant External Links for GMEB1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GMEB1
genes like me logo Genes that share disorders with GMEB1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GMEB1 Gene

Publications for GMEB1 Gene

  1. Cloning and characterization of hGMEB1, a novel glucocorticoid modulatory element binding protein. (PMID: 10386584) Theriault J.R. … Landry J. (FEBS Lett. 1999) 2 23 67
  2. Structure/activity relationships for GMEB-2: the second member of the glucocorticoid modulatory element-binding complex. (PMID: 14705952) Chen J. … Simons S.S. (Biochemistry 2004) 23 67
  3. Crystal structure and nuclear magnetic resonance analyses of the SAND domain from glucocorticoid modulatory element binding protein-1 reveals deoxyribonucleic acid and zinc binding regions. (PMID: 12702733) Surdo P.L. … Scheffzek K. (Mol. Endocrinol. 2003) 23 67
  4. Properties of the glucocorticoid modulatory element binding proteins GMEB-1 and -2: potential new modifiers of glucocorticoid receptor transactivation and members of the family of KDWK proteins. (PMID: 10894151) Kaul S. … Simons S.S. Jr. (Mol. Endocrinol. 2000) 23 67
  5. Two new members of the emerging KDWK family of combinatorial transcription modulators bind as a heterodimer to flexibly spaced PuCGPy half-sites. (PMID: 10523663) Christensen J. … Tattersall P. (Mol. Cell. Biol. 1999) 2 67

Products for GMEB1 Gene

Sources for GMEB1 Gene

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