Aliases for GMDS Gene
External Ids for GMDS Gene
Previous GeneCards Identifiers for GMDS Gene
GDP-mannose 4,6-dehydratase (GMD; EC 188.8.131.52) catalyzes the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, the first step in the synthesis of GDP-fucose from GDP-mannose, using NADP+ as a cofactor. The second and third steps of the pathway are catalyzed by a single enzyme, GDP-keto-6-deoxymannose 3,5-epimerase, 4-reductase, designated FX in humans (MIM 137020).[supplied by OMIM, Aug 2009]
GeneCards Summary for GMDS Gene
GMDS (GDP-Mannose 4,6-Dehydratase) is a Protein Coding gene. Diseases associated with GMDS include Congenital Disorder Of Glycosylation, Type Iic and Leukocyte Adhesion Deficiency. Among its related pathways are Synthesis of substrates in N-glycan biosythesis and Transport to the Golgi and subsequent modification. GO annotations related to this gene include coenzyme binding and NADP+ binding.
UniProtKB/Swiss-Prot for GMDS Gene
Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.