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Aliases for GMCL1P1 Gene

Subcategory (RNA class) for GMCL1P1 Gene

lncRNA

Aliases for GMCL1P1 Gene

  • Germ Cell-Less, Spermatogenesis Associated 1 Pseudogene 1 2 3
  • GMCL1L 3 4
  • GCL 3 4
  • Germ Cell-Less Homolog 1 (Drosophila) Pseudogene 1 2
  • Germ Cell-Less Homolog 1 (Drosophila)-Like 2
  • Germ Cell-Less Homolog 1 Pseudogene 1 3
  • Germ Cell-Less Related 3
  • GMCL2 3

External Ids for GMCL1P1 Gene

ORGUL Members for GMCL1P1 Gene

Previous Symbols for GMCL1P1 Gene

  • GMCL1L

Summaries for GMCL1P1 Gene

Entrez Gene Summary for GMCL1P1 Gene

  • This locus shares a high degree of identity with the multi-exon germ cell-less gene on chromosome 2. Despite its single-exon nature, this chromosome 5 locus contains an open reading frame that could putatively encode a full-length germ cell-less related protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for GMCL1P1 Gene

GMCL1P1 (Germ Cell-Less, Spermatogenesis Associated 1 Pseudogene 1) is a Pseudogene, and belongs to the lncRNA class. Diseases associated with GMCL1P1 include colorectal cancer.

UniProtKB/Swiss-Prot for GMCL1P1 Gene

  • Possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport (By similarity). Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GMCL1P1 Gene

Genomics for GMCL1P1 Gene

Genomic Location for GMCL1P1 Gene

Start:
178,184,510 bp from pter
End:
178,187,432 bp from pter
Size:
2,923 bases
Orientation:
Minus strand

Genomic View for GMCL1P1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GMCL1P1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GMCL1P1 Gene

No data available for Regulatory Elements for GMCL1P1 Gene

Proteins for GMCL1P1 Gene

  • Protein details for GMCL1P1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEA9-GMCLL_HUMAN
    Recommended name:
    Putative germ cell-less protein-like 1-like
    Protein Accession:
    Q8NEA9
    Secondary Accessions:
    • B2RDW6
    • Q8TC88
    • Q8TC89

    Protein attributes for GMCL1P1 Gene

    Size:
    526 amino acids
    Molecular mass:
    60201 Da
    Quaternary structure:
    • Interacts with TMPO-Beta, TSG101 and TFDP2. Interacts with EMD (By similarity). Interacts with CUL3.

neXtProt entry for GMCL1P1 Gene

Proteomics data for GMCL1P1 Gene at MOPED

Post-translational modifications for GMCL1P1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GMCL1P1 Gene

Domains for GMCL1P1 Gene

Protein Domains for GMCL1P1 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8NEA9

UniProtKB/Swiss-Prot:

GMCLL_HUMAN
Domain:
  • Contains 1 BTB (POZ) domain.:
    • Q8NEA9
genes like me logo Genes that share domains with GMCL1P1: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for GMCL1P1 Gene

Function for GMCL1P1 Gene

Molecular function for GMCL1P1 Gene

UniProtKB/Swiss-Prot Function: Possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport (By similarity). Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Gene Ontology (GO) - Molecular Function for GMCL1P1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with GMCL1P1: view

miRNA for GMCL1P1 Gene

miRTarBase miRNAs that target GMCL1P1

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for GMCL1P1 Gene

Localization for GMCL1P1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GMCL1P1 Gene

Nucleus matrix.

Gene Ontology (GO) - Cellular Components for GMCL1P1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016363 nuclear matrix IEA --
genes like me logo Genes that share ontologies with GMCL1P1: view

No data available for Subcellular locations from COMPARTMENTS for GMCL1P1 Gene

Pathways for GMCL1P1 Gene

SuperPathways for GMCL1P1 Gene

No Data Available

UniProtKB/Swiss-Prot Q8NEA9-GMCLL_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for GMCL1P1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development IEA --
GO:0007283 spermatogenesis IEA --
GO:0016567 protein ubiquitination IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with GMCL1P1: view

No data available for Pathways by source for GMCL1P1 Gene

Transcripts for GMCL1P1 Gene

mRNA/cDNA for GMCL1P1 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(22) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GMCL1P1 Gene

Germ cell-less, spermatogenesis associated 1 pseudogene 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GMCL1P1 Gene

No ASD Table

Relevant External Links for GMCL1P1 Gene

GeneLoc Exon Structure for
GMCL1P1
ECgene alternative splicing isoforms for
GMCL1P1

Expression for GMCL1P1 Gene

mRNA expression in normal human tissues for GMCL1P1 Gene

mRNA differential expression in normal tissues according to GTEx for GMCL1P1 Gene

This gene is overexpressed in Testis (50.7).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for GMCL1P1 Gene

SOURCE GeneReport for Unigene cluster for GMCL1P1 Gene Hs.591738

genes like me logo Genes that share expressions with GMCL1P1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for GMCL1P1 Gene

Orthologs for GMCL1P1 Gene

Evolution for GMCL1P1 Gene

ENSEMBL:
Gene Tree for GMCL1P1 (if available)
TreeFam:
Gene Tree for GMCL1P1 (if available)

No data available for Orthologs for GMCL1P1 Gene

Paralogs for GMCL1P1 Gene

Selected SIMAP similar genes for GMCL1P1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GMCL1P1: view

No data available for Paralogs for GMCL1P1 Gene

Variants for GMCL1P1 Gene

Sequence variations from dbSNP and Humsavar for GMCL1P1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs2913782 -- 178,187,089(+) CTCAT(C/G)CTCCT nc-transcript-variant
rs2913783 -- 178,187,182(+) GTAGC(C/T)CGCCG nc-transcript-variant
rs2913792 -- 178,188,364(+) ATAAA(C/G)ACTTG upstream-variant-2KB
rs2913797 -- 178,189,111(+) AAGAG(C/T)GACCA upstream-variant-2KB
rs2961663 -- 178,186,543(+) TATAC(C/T)GAGTT nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for GMCL1P1 Gene

Variant ID Type Subtype PubMed ID
nsv883190 CNV Loss 21882294
nsv883193 CNV Loss 21882294
nsv883194 CNV Loss 21882294

Relevant External Links for GMCL1P1 Gene

HapMap Linkage Disequilibrium report
GMCL1P1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GMCL1P1 Gene

Disorders for GMCL1P1 Gene

(1) MalaCards Diseases for GMCL1P1 Gene

Search for GMCL1P1 Gene in MalaCards »
genes like me logo Genes that share disorders with GMCL1P1: view

No data available for UniProtKB/Swiss-Prot for GMCL1P1 Gene

Publications for GMCL1P1 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry. (PMID: 16094384) Tao W.A. … Aebersold R. (Nat. Methods 2005) 3
  3. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3
  4. Emergence of young human genes after a burst of retroposition in primates. (PMID: 16201836) Marques A.C. … Kaessmann H. (PLoS Biol. 2005) 3
  5. Genetic variants of microsomal epoxide hydrolase and glutamate-cysteine ligase in COPD. (PMID: 18614560) Chappell S. … Kalsheker N. (Eur. Respir. J. 2008) 3

Products for GMCL1P1 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate GMCL1P1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for GMCL1P1
    • Block miRNA regulation of GMCL1P1 using miScript Target Protectors

    Sources for GMCL1P1 Gene

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