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Aliases for GMCL1P1 Gene

Subcategory (RNA class) for GMCL1P1 Gene

lncRNA

Aliases for GMCL1P1 Gene

  • Germ Cell-Less, Spermatogenesis Associated 1 Pseudogene 1 2 3 5
  • GMCL1L 3 4
  • GCL 3 4
  • Germ Cell-Less Homolog 1 (Drosophila) Pseudogene 1 2
  • Germ Cell-Less Homolog 1 (Drosophila)-Like 2
  • Germ Cell-Less Homolog 1 Pseudogene 1 3
  • Germ Cell-Less Related 3
  • GMCL2 3

External Ids for GMCL1P1 Gene

ORGUL Members for GMCL1P1 Gene

Previous HGNC Symbols for GMCL1P1 Gene

  • GMCL1L

Previous GeneCards Identifiers for GMCL1P1 Gene

  • GC05M177611

Summaries for GMCL1P1 Gene

Entrez Gene Summary for GMCL1P1 Gene

  • This locus shares a high degree of identity with the multi-exon germ cell-less gene on chromosome 2. Despite its single-exon nature, this chromosome 5 locus contains an open reading frame that could putatively encode a full-length germ cell-less related protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for GMCL1P1 Gene

GMCL1P1 (Germ Cell-Less, Spermatogenesis Associated 1 Pseudogene 1) is a Pseudogene, and is affiliated with the lncRNA class.

UniProtKB/Swiss-Prot for GMCL1P1 Gene

  • Possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport (By similarity). Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GMCL1P1 Gene

Genomics for GMCL1P1 Gene

Regulatory Elements for GMCL1P1 Gene

Enhancers for GMCL1P1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GMCL1P1 on UCSC Golden Path with GeneCards custom track

Promoters for GMCL1P1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GMCL1P1 on UCSC Golden Path with GeneCards custom track

Genomic Location for GMCL1P1 Gene

Chromosome:
5
Start:
178,184,510 bp from pter
End:
178,187,432 bp from pter
Size:
2,923 bases
Orientation:
Minus strand

Genomic View for GMCL1P1 Gene

Genes around GMCL1P1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GMCL1P1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GMCL1P1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GMCL1P1 Gene

Proteins for GMCL1P1 Gene

  • Protein details for GMCL1P1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEA9-GMCLL_HUMAN
    Recommended name:
    Putative germ cell-less protein-like 1-like
    Protein Accession:
    Q8NEA9
    Secondary Accessions:
    • B2RDW6
    • Q8TC88
    • Q8TC89

    Protein attributes for GMCL1P1 Gene

    Size:
    526 amino acids
    Molecular mass:
    60201 Da
    Quaternary structure:
    • Interacts with TMPO-Beta, TSG101 and TFDP2. Interacts with EMD (By similarity). Interacts with CUL3.

neXtProt entry for GMCL1P1 Gene

Proteomics data for GMCL1P1 Gene at MOPED

Post-translational modifications for GMCL1P1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GMCL1P1 Gene

Domains & Families for GMCL1P1 Gene

Protein Domains for GMCL1P1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for GMCL1P1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NEA9

UniProtKB/Swiss-Prot:

GMCLL_HUMAN :
  • Contains 1 BTB (POZ) domain.
Domain:
  • Contains 1 BTB (POZ) domain.
genes like me logo Genes that share domains with GMCL1P1: view

No data available for Gene Families for GMCL1P1 Gene

Function for GMCL1P1 Gene

Molecular function for GMCL1P1 Gene

UniProtKB/Swiss-Prot Function:
Possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport (By similarity). Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

miRNA for GMCL1P1 Gene

miRTarBase miRNAs that target GMCL1P1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GMCL1P1 Gene

Localization for GMCL1P1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GMCL1P1 Gene

Nucleus matrix.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for GMCL1P1 Gene

Pathways & Interactions for GMCL1P1 Gene

SuperPathways for GMCL1P1 Gene

No Data Available

UniProtKB/Swiss-Prot Q8NEA9-GMCLL_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for GMCL1P1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with GMCL1P1: view

No data available for Pathways by source and SIGNOR curated interactions for GMCL1P1 Gene

Drugs & Compounds for GMCL1P1 Gene

No Compound Related Data Available

Transcripts for GMCL1P1 Gene

mRNA/cDNA for GMCL1P1 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(22) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GMCL1P1 Gene

Germ cell-less, spermatogenesis associated 1 pseudogene 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GMCL1P1 Gene

No ASD Table

Relevant External Links for GMCL1P1 Gene

GeneLoc Exon Structure for
GMCL1P1
ECgene alternative splicing isoforms for
GMCL1P1

Expression for GMCL1P1 Gene

mRNA expression in normal human tissues for GMCL1P1 Gene

mRNA differential expression in normal tissues according to GTEx for GMCL1P1 Gene

This gene is overexpressed in Testis (x50.7).

Protein differential expression in normal tissues from HIPED for GMCL1P1 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GMCL1P1 Gene



SOURCE GeneReport for Unigene cluster for GMCL1P1 Gene Hs.591738

genes like me logo Genes that share expression patterns with GMCL1P1: view

Protein tissue co-expression partners for GMCL1P1 Gene

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for GMCL1P1 Gene

Orthologs for GMCL1P1 Gene

Evolution for GMCL1P1 Gene

ENSEMBL:
Gene Tree for GMCL1P1 (if available)
TreeFam:
Gene Tree for GMCL1P1 (if available)

No data available for Orthologs for GMCL1P1 Gene

Paralogs for GMCL1P1 Gene

(3) SIMAP similar genes for GMCL1P1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GMCL1P1: view

No data available for Paralogs for GMCL1P1 Gene

Variants for GMCL1P1 Gene

Sequence variations from dbSNP and Humsavar for GMCL1P1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
VAR_035924 A colorectal cancer sample
rs2913782 -- 178,187,089(+) CTCAT(C/G)CTCCT nc-transcript-variant
rs2913783 -- 178,187,182(+) GTAGC(C/T)CGCCG nc-transcript-variant
rs2913792 -- 178,188,364(+) ATAAA(C/G)ACTTG upstream-variant-2KB
rs2913797 -- 178,189,111(+) AAGAG(C/T)GACCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GMCL1P1 Gene

Variant ID Type Subtype PubMed ID
nsv883190 CNV Loss 21882294
nsv883193 CNV Loss 21882294
nsv883194 CNV Loss 21882294

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Variation tolerance and Relevant External Links for GMCL1P1 Gene

Disorders for GMCL1P1 Gene

Relevant External Links for GMCL1P1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GMCL1P1

No disorders were found for GMCL1P1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GMCL1P1 Gene

Publications for GMCL1P1 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Novel Cul3 binding proteins function to remodel E3 ligase complexes. (PMID: 25011449) Wimuttisuk W. … Singer J.D. (BMC Cell Biol. 2014) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis. (PMID: 21156761) Padyukov L. … Klareskog L. (Ann. Rheum. Dis. 2011) 3
  5. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3

Products for GMCL1P1 Gene

Sources for GMCL1P1 Gene

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