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GMCL1 Gene

protein-coding   GIFtS: 46
GCID: GC02P070056

Germ Cell-Less, Spermatogenesis Associated 1

(Previous name: germ cell-less homolog 1 (Drosophila))
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Germ Cell-Less, Spermatogenesis Associated 11 2     GCL12
Spermatogenesis Associated 291 2     SPATA292
GCL2 3     Germ Cell-Less Homolog 12
Germ Cell-Less Homolog 1 (Drosophila)1     Germ Cell-Less Protein-Like 12
BTBD132     

External Ids:    HGNC: 238431   Entrez Gene: 643952   Ensembl: ENSG000000873387   UniProtKB: Q96IK53   

Export aliases for GMCL1 gene to outside databases

Previous GC identifer: GC02P069969


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GMCL1 Gene:
This gene encodes a nuclear envelope protein that appears to be involved in spermatogenesis, either directly or by
influencing genes that play a more direct role in the process. This multi-exon locus is the homolog of the mouse
and drosophila germ cell-less gene but the human genome also contains a single-exon locus on chromosome 5 that
contains an open reading frame capable of encoding a highly-related protein. (provided by RefSeq, Jul 2008)

GeneCards Summary for GMCL1 Gene:
GMCL1 (germ cell-less, spermatogenesis associated 1) is a protein-coding gene. Diseases associated with GMCL1 include malaria. An important paralog of this gene is BTBD16.

UniProtKB/Swiss-Prot: GMCL1_HUMAN, Q96IK5
Function: Possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53
probably by modulating the nucleocytoplasmic transport (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_022184.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the GMCL1 gene promoter:
         Nkx3-1   Nkx3-1 v4   ATF-2   Nkx3-1 v1   MZF-1   Nkx3-1 v2   Nkx3-1 v3   Pax-4a   ATF6   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGMCL1 promoter sequence
   Search Chromatin IP Primers for GMCL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GMCL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p13.3   Ensembl cytogenetic band:  2p13.3   HGNC cytogenetic band: 2p13.3

GMCL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GMCL1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P070056:  view genomic region     (about GC identifiers)

Start:
70,056,774 bp from pter      End:
70,108,528 bp from pter
Size:
51,755 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: GMCL1_HUMAN, Q96IK5 (See protein sequence)
Recommended Name: Germ cell-less protein-like 1  
Size: 515 amino acids; 58685 Da
Subunit: Interacts with TMPO-beta, TSG101 and TFDP2 (By similarity). Interacts with EMD
Sequence caution: Sequence=BAB14494.1; Type=Erroneous initiation;
Secondary accessions: Q9H826 Q9H8V7 Q9H927

Explore the universe of human proteins at neXtProt for GMCL1: NX_Q96IK5

Explore proteomics data for GMCL1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See GMCL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_848526.1  
    ENSEMBL proteins: 
     ENSP00000282570  

    GMCL1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for GMCL1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    BTBD: BTB/POZ domain containing

    4 InterPro protein domains:
     IPR000210 BTB/POZ-like
     IPR011333 BTB/POZ_fold
     IPR013069 BTB_POZ
     IPR011705 BACK

    Graphical View of Domain Structure for InterPro Entry Q96IK5

    ProtoNet protein and cluster: Q96IK5

    1 Blocks protein domain: IPB000210 BTB/POZ domain

    UniProtKB/Swiss-Prot: GMCL1_HUMAN, Q96IK5
    Similarity: Contains 1 BTB (POZ) domain


    GMCL1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GMCL1_HUMAN, Q96IK5
    Function: Possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53
    probably by modulating the nucleocytoplasmic transport (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    GMCL1 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Gmcl1):
     cellular  reproductive system 

    GMCL1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Gmcl1tm1Nkn for GMCL1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GMCL1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GMCL1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GMCL1

    miRNA
    Products:
        
    miRTarBase miRNAs that target GMCL1:
    hsa-mir-124-3p (MIRT022371)

    Block miRNA regulation of human, mouse, rat GMCL1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GMCL1 (see all 24):
    hsa-miR-320a hsa-miR-607 hsa-miR-4328 hsa-miR-106a hsa-miR-578 hsa-miR-3142 hsa-miR-320e hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidGMCL1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat GMCL1

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    GenScript: all cDNA clones in your preferred vector: GMCL1 (NM_178439)
    Browse Sino Biological Human cDNA Clones
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GMCL1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GMCL1_HUMAN, Q96IK5: Nucleus matrix (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    cytoskeleton1
    endoplasmic reticulum1
    extracellular1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005635nuclear envelope IEA--
    GO:0016363nuclear matrix IEA--

    GMCL1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GMCL1
    Interactions:

        GeneGlobe Interaction Network for GMCL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for GMCL1 (Q96IK53 ENSP000002825704) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TSG101Q998163, ENSP000002519684I2D: score=3 STRING: ENSP00000251968
    EMDP504023, ENSP000003588574I2D: score=2 STRING: ENSP00000358857
    TMPOP421663, ENSP000002667324I2D: score=3 STRING: ENSP00000266732
    COPS4Q9BT783I2D: score=5 
    MEIS2O147703I2D: score=4 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0007275multicellular organismal development IEA--
    GO:0007283spermatogenesis IEA--
    GO:0030154cell differentiation IEA--

    GMCL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GMCL1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for GMCL1 gene: 
    NM_178439.3  

    Unigene Cluster for GMCL1:

    Germ cell-less, spermatogenesis associated 1
    Hs.293971  [show with all ESTs]
    Unigene Representative Sequence: AK023261
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000282570(uc002sfu.3) ENST00000468386 ENST00000471404 ENST00000495047

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat GMCL1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GMCL1 (see all 24):
    hsa-miR-320a hsa-miR-607 hsa-miR-4328 hsa-miR-106a hsa-miR-578 hsa-miR-3142 hsa-miR-320e hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidGMCL1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for GMCL1
    Predesigned siRNA for gene silencing in human, mouse, rat GMCL1
    Clone
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    OriGene ORF clones in mouse, rat for GMCL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GMCL1 (NM_178439)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GMCL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GMCL1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for GMCL1
    OriGene qSTAR qPCR primer pairs in human, mouse for GMCL1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GMCL1
      QuantiTect SYBR Green Assays in human, mouse, rat GMCL1
      QuantiFast Probe-based Assays in human, mouse, rat GMCL1

    Additional mRNA sequence: 

    AK023119.1 AK023261.1 AK024042.1 BC007420.2 

    7 DOTS entries:

    DT.412040  DT.120958581  DT.95166213  DT.100669772  DT.120958572  DT.100784422  DT.95166214 

    Selected AceView cDNA sequences (see all 131):

    AI093913 C05208 BC007420 BQ025903 BX282133 AA732408 AI962848 AI568212 
    AI469125 AA831712 BX377384 BX489304 BX282019 AW769104 AK023119 BG621706 
    AW340831 CK902338 BE048386 AI886237 AA999677 C05569 AV651055 AA376848 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GMCL1 expression in normal human tissues (normalized intensities)      GMCL1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    GMCL1 Expression
    About this image


    GMCL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Gonad (Reproductive System)
             Primordial Germ Cells Primitive Gonad
     
     Testis (Reproductive System)
    GMCL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GMCL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.293971
        Custom PCR Arrays for GMCL1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GMCL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for GMCL1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gmcl11 , 5 germ cell-less homolog 1 (Drosophila)1, 5 87.39(n)1
    91.42(a)1
      6 (37.75 cM)5
    238851  NM_011818.31  NP_035948.31 
     866917685 
    chicken
    (Gallus gallus)
    Aves GMCL11 germ cell-less homolog 1 (Drosophila) 74.2(n)
    86.48(a)
      426327  XM_423987.4  XP_423987.4 
    lizard
    (Anolis carolinensis)
    Reptilia GMCL16
    germ cell-less, spermatogenesis associated 1
    76(a)
    1 ↔ 1
    AAWZ02037037(695-14950)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia gmcl11 germ cell-less, spermatogenesis associated 1 75.38(n)
    81.98(a)
      780182  NM_001079257.1  NP_001072725.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb51d082 Danio rerio mRNA similar to germ cell-less homolog (Drosophila) (cDNA clone MGC55933 IMAGE3819216), complete cds less 72.12(n)    BC047197.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta gcl1 germ cell-less 46.54(n)
    37.76(a)
      35864  NM_165622.1  NP_724708.1 
    worm
    (Caenorhabditis elegans)
    Secernentea gcl-11 gcl-1 48.57(n)
    33.8(a)
      190457  NM_070184.4  NP_502585.1 


    ENSEMBL Gene Tree for GMCL1 (if available)
    TreeFam Gene Tree for GMCL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GMCL1 gene
    BTBD162  
    3 SIMAP similar genes for GMCL1 using alignment to 1 protein entry:     GMCL1_HUMAN:
    FLJ13057    GCL    GMCL1P1

    GMCL1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for GMCL1
    PGOHUM00000240840 PGOHUM00000235472


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GMCL1 (see all 997)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs358636881,2
    C--69819797(+) TTTTT-/T/TT  
            
    AACTT
    1 -- int11NA 2
    rs1142041771,2
    F--70054980(+) TACCAT/CGTCTG 1 -- us2k11Minor allele frequency- C:0.01WA 118
    rs75723811,2
    C,F,H--70055042(+) GTCATT/GGCTGT 1 -- us2k117Minor allele frequency- G:0.18NS EA NA WA 1736
    rs1391538261,2
    C--70055119(+) GGTTC-/CTTT  
            
    GTCAA
    1 -- us2k10--------
    rs339924371,2
    C,F,H--70055171(+) CAAATG/CTGTAC 1 -- us2k122Minor allele frequency- C:0.24NS EA NA WA 2766
    rs75753021,2
    C,F--70055236(+) TTCATT/CGCCTT 1 -- us2k16Minor allele frequency- C:0.22NA WA EA 364
    rs728952211,2
    C,F--70055251(+) CCAGGC/ACTGTT 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs755331701,2
    C,F--70055438(+) TGCATG/AAATCA 1 -- us2k11Minor allele frequency- A:0.05WA 118
    rs1410005361,2
    --70055488(+) CAATGA/GGAGTC 1 -- us2k10--------
    rs15310251,2
    C,F,A,H--70055505(+) GGTACA/CTTGAT 1 -- us2k121Minor allele frequency- C:0.26NS EA NA WA CSA 1806

    HapMap Linkage Disequilibrium report for GMCL1 (70056774 - 70108528 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for GMCL1:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv634n67CNV Loss20364138
    nsv834254CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GMCL1
    DNA2.0 Custom Variant and Variant Library Synthesis for GMCL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for GMCL1:    About MalaCards
    malaria


    GMCL1 for disorders           About GeneDecksing


    Export disorders for GMCL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GMCL1 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with GMCL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Transcriptional repressor germ cell-less (GCL) and barrier to autointegration factor (BAF) compete for binding to emerin in vitro. (PubMed id 12493765)1, 2 Holaska J.M.... Wilson K.L. (J. Biol. Chem. 2003)
    4. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    5. GAGE cancer-germline antigens are recruited to the nuclear envelope by germ cell-less (GCL). (PubMed id 23029259)1 Gjerstorff M.F....Ditzel H.J. (PLoS ONE 2012)
    6. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)
    7. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    8. Reduced human germ cell-less (HGCL) expression in azoospermic men with severe germinal cell impairment. (PubMed id 12954656)1 Kleiman S.E....Simon A.J. (J. Androl. 2003)
    9. Enhanced degradation of MDM2 by a nuclear envelope component, mouse germ cell-less. (PubMed id 12927808)1 Masuhara M....Nakano T. (Biochem. Biophys. Res. Commun. 2003)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64395 HGNC: 23843 AceView: GCL Ensembl:ENSG00000087338 euGenes: HUgn64395
    ECgene: GMCL1 H-InvDB: GMCL1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GMCL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GMCL1 gene:
    Search GeneIP for patents involving GMCL1

    GeneCards and IP:
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