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Aliases for GMCL1 Gene

Aliases for GMCL1 Gene

  • Germ Cell-Less, Spermatogenesis Associated 1 2 3 5
  • Spermatogenesis Associated 29 2 3
  • GCL 3 4
  • Germ Cell-Less Homolog 1 (Drosophila) 2
  • Germ Cell-Less Homolog 1 3
  • SPATA29 3
  • BTBD13 3
  • GCL1 3

External Ids for GMCL1 Gene

Previous GeneCards Identifiers for GMCL1 Gene

  • GC02P069969
  • GC02P070056

Summaries for GMCL1 Gene

Entrez Gene Summary for GMCL1 Gene

  • This gene encodes a nuclear envelope protein that appears to be involved in spermatogenesis, either directly or by influencing genes that play a more direct role in the process. This multi-exon locus is the homolog of the mouse and drosophila germ cell-less gene but the human genome also contains a single-exon locus on chromosome 5 that contains an open reading frame capable of encoding a highly-related protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for GMCL1 Gene

GMCL1 (Germ Cell-Less, Spermatogenesis Associated 1) is a Protein Coding gene. An important paralog of this gene is BTBD16.

UniProtKB/Swiss-Prot for GMCL1 Gene

  • Possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GMCL1 Gene

Genomics for GMCL1 Gene

Regulatory Elements for GMCL1 Gene

Enhancers for GMCL1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GMCL1 on UCSC Golden Path with GeneCards custom track

Promoters for GMCL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GMCL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for GMCL1 Gene

69,829,642 bp from pter
69,881,396 bp from pter
51,755 bases
Plus strand

Genomic View for GMCL1 Gene

Genes around GMCL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GMCL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GMCL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GMCL1 Gene

Proteins for GMCL1 Gene

  • Protein details for GMCL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Germ cell-less protein-like 1
    Protein Accession:
    Secondary Accessions:
    • Q9H826
    • Q9H8V7
    • Q9H927

    Protein attributes for GMCL1 Gene

    515 amino acids
    Molecular mass:
    58685 Da
    Quaternary structure:
    • Interacts with TMPO-beta, TSG101 and TFDP2 (By similarity). Interacts with EMD.
    • Sequence=BAB14494.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for GMCL1 Gene

Proteomics data for GMCL1 Gene at MOPED

Post-translational modifications for GMCL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GMCL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for GMCL1

No data available for DME Specific Peptides for GMCL1 Gene

Domains & Families for GMCL1 Gene

Gene Families for GMCL1 Gene

Protein Domains for GMCL1 Gene


Suggested Antigen Peptide Sequences for GMCL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 BTB (POZ) domain.
  • Contains 1 BTB (POZ) domain.
genes like me logo Genes that share domains with GMCL1: view

Function for GMCL1 Gene

Molecular function for GMCL1 Gene

UniProtKB/Swiss-Prot Function:
Possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport (By similarity).
genes like me logo Genes that share phenotypes with GMCL1: view

Animal Models for GMCL1 Gene

MGI Knock Outs for GMCL1:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GMCL1 Gene

Localization for GMCL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GMCL1 Gene

Nucleus matrix.

Subcellular locations from

Jensen Localization Image for GMCL1 Gene COMPARTMENTS Subcellular localization image for GMCL1 gene
Compartment Confidence
nucleus 4
cytosol 3
cytoskeleton 1
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for GMCL1 Gene

Pathways & Interactions for GMCL1 Gene

SuperPathways for GMCL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GMCL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with GMCL1: view

No data available for Pathways by source and SIGNOR curated interactions for GMCL1 Gene

Drugs & Compounds for GMCL1 Gene

No Compound Related Data Available

Transcripts for GMCL1 Gene

Unigene Clusters for GMCL1 Gene

Germ cell-less, spermatogenesis associated 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GMCL1 Gene

No ASD Table

Relevant External Links for GMCL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GMCL1 Gene

mRNA expression in normal human tissues for GMCL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GMCL1 Gene

This gene is overexpressed in Testis (40.2) and Placenta (28.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GMCL1 Gene

SOURCE GeneReport for Unigene cluster for GMCL1 Gene Hs.293971

genes like me logo Genes that share expression patterns with GMCL1: view

Protein tissue co-expression partners for GMCL1 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GMCL1 Gene

Orthologs for GMCL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GMCL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GMCL1 35
  • 92.62 (n)
  • 93.98 (a)
GMCL1 36
  • 92 (a)
(Canis familiaris)
Mammalia GMCL1 35
  • 92.22 (n)
  • 92.22 (a)
GMCL1 36
  • 90 (a)
(Mus musculus)
Mammalia Gmcl1 35
  • 87.39 (n)
  • 91.42 (a)
Gmcl1 16
Gmcl1 36
  • 89 (a)
(Pan troglodytes)
Mammalia GMCL1 35
  • 94.87 (n)
  • 91.62 (a)
GMCL1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Gmcl1 35
  • 86.81 (n)
  • 91.81 (a)
(Monodelphis domestica)
Mammalia GMCL1 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 15 (a)
(Gallus gallus)
Aves GMCL1 35
  • 74.2 (n)
  • 86.48 (a)
GMCL1 36
  • 72 (a)
(Anolis carolinensis)
Reptilia GMCL1 36
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gmcl1 35
  • 75.38 (n)
  • 81.98 (a)
(Danio rerio)
Actinopterygii gmcl1 35
  • 67.08 (n)
  • 74.95 (a)
wufb51d08 35
gmcl1 36
  • 72 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011686 35
  • 46.16 (n)
  • 40.38 (a)
fruit fly
(Drosophila melanogaster)
Insecta gcl 35
  • 46.54 (n)
  • 37.76 (a)
gcl 36
  • 28 (a)
(Caenorhabditis elegans)
Secernentea gcl-1 35
  • 48.57 (n)
  • 33.8 (a)
gcl-1 36
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
Species with no ortholog for GMCL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GMCL1 Gene

Gene Tree for GMCL1 (if available)
Gene Tree for GMCL1 (if available)

Paralogs for GMCL1 Gene

Paralogs for GMCL1 Gene

(3) SIMAP similar genes for GMCL1 Gene using alignment to 1 proteins: Pseudogenes for GMCL1 Gene

genes like me logo Genes that share paralogs with GMCL1: view

Variants for GMCL1 Gene

Sequence variations from dbSNP and Humsavar for GMCL1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1551374 -- 69,852,501(+) ATCAC(C/T)TGTGA intron-variant
rs921711 -- 69,857,845(+) CATGT(G/T)AGTGT intron-variant
rs2872075 -- 69,841,503(+) TCATT(G/T)AAGAG intron-variant
rs2872076 -- 69,841,623(+) AGGGA(A/G)GGTTG intron-variant
rs1013083 -- 69,872,292(+) CTGCA(A/G)TGTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GMCL1 Gene

Variant ID Type Subtype PubMed ID
nsv834254 CNV Gain 17160897
dgv634n67 CNV Loss 20364138

Variation tolerance for GMCL1 Gene

Residual Variation Intolerance Score: 33.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.85; 34.73% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GMCL1 Gene

Disorders for GMCL1 Gene

Relevant External Links for GMCL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GMCL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GMCL1 Gene

Publications for GMCL1 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. GAGE cancer-germline antigens are recruited to the nuclear envelope by germ cell-less (GCL). (PMID: 23029259) Gjerstorff M.F. … Ditzel H.J. (PLoS ONE 2012) 3

Products for GMCL1 Gene

Sources for GMCL1 Gene