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GLYR1 Gene

protein-coding   GIFtS: 50
GCID: GC16M004855

Glyoxylate Reductase 1 Homolog (Arabidopsis)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Glyoxylate Reductase 1 Homolog (Arabidopsis)1 2     HIBDL2 3
NP602 3 5     BM0452
Nuclear Protein 60kDa1 2     N-PAC2
Cytokine-Like Nuclear Factor N-PAC2 3     Nuclear Protein 60 KDa2
Nuclear Protein NP602 3     Putative Oxidoreductase GLYR12
Nuclear Protein Of 60 KDa2 3     EC 1.-.-.-3
3-Hydroxyisobutyrate Dehydrogenase-Like Protein2 3     Glyoxylate Reductase 1 Homolog3

External Ids:    HGNC: 244341   Entrez Gene: 846562   Ensembl: ENSG000001406327   OMIM: 6106605   UniProtKB: Q49A263   

Export aliases for GLYR1 gene to outside databases

Previous GC identifer: GC16M004794


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for GLYR1 Gene:
GLYR1 (glyoxylate reductase 1 homolog (Arabidopsis)) is a protein-coding gene. Diseases associated with GLYR1 include band keratopathy, and nasopharynx carcinoma. GO annotations related to this gene include phosphogluconate dehydrogenase (decarboxylating) activity and methylated histone residue binding. An important paralog of this gene is HIBADH.

UniProtKB/Swiss-Prot: GLYR1_HUMAN, Q49A26
Function: May have oxidoreductase activity. Regulates p38 MAP kinase activity by mediating stress activation of
p38alpha/MAPK14 and specifically regulating MAPK14 signaling. Indirectly promotes phosphorylation of MAPK14 and
activation of ATF2. The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6. Recruited on
chromatin, recognizes and binds trimethylated 'Lys-36' of histone H3 (H3K36me3)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NT_010393.17  NC_018927.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for GLYR1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGLYR1 promoter sequence
   Search Chromatin IP Primers for GLYR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GLYR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

GLYR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GLYR1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M004855:  view genomic region     (about GC identifiers)

Start:
4,853,204 bp from pter      End:
4,897,343 bp from pter
Size:
44,140 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GLYR1_HUMAN, Q49A26 (See protein sequence)
Recommended Name: Putative oxidoreductase GLYR1  
Size: 553 amino acids; 60556 Da
Subunit: Interacts with MAPK14
Miscellaneous: The conserved NAD-binding sites and sequence similarity to plant dehydrogenases suggest that this
protein may have oxidoreductase activity
6 PDB 3D structures from and Proteopedia for GLYR1:
2UYY (3D)        4GUR (3D)        4GUS (3D)        4GUT (3D)        4GUU (3D)        4HSU (3D)    
Secondary accessions: B4DL47 C9JJ40 C9JJ60 Q5U632 Q6P1Q2 Q6V3W7 Q9BTI1 Q9BXK2
Alternative splicing: 5 isoforms:  Q49A26-1   Q49A26-2   Q49A26-5   Q49A26-3   Q49A26-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for GLYR1: NX_Q49A26

Explore proteomics data for GLYR1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys211, Lys335, Lys338, Lys495, Lys532, Lys535
  • Modification sites at PhosphoSitePlus

  • See GLYR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_115958.2  
    ENSEMBL proteins: 
     ENSP00000466570   ENSP00000466127   ENSP00000390276   ENSP00000322716   ENSP00000465490  
     ENSP00000468328   ENSP00000467751   ENSP00000467541   ENSP00000371413  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 7):
     IPR006115 6PGDH_NADP-bd
     IPR017956 AT_hook_DNA-bd_motif
     IPR008927 6-PGluconate_DH_C-like
     IPR015815 HIBADH-type
     IPR013328 DH_multihelical

    Graphical View of Domain Structure for InterPro Entry Q49A26

    ProtoNet protein and cluster: Q49A26

    2 Blocks protein domains:
    IPB000313 PWWP domain
    IPB002204 3-hydroxyisobutyrate dehydrogenase


    UniProtKB/Swiss-Prot: GLYR1_HUMAN, Q49A26
    Domain: The A.T hook DNA-binding domain is required for the interaction with MAPK14
    Domain: The PWWP domain probably mediates the binding to H3K36me3
    Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family. NP60 subfamily
    Similarity: Contains 1 A.T hook DNA-binding domain
    Similarity: Contains 1 PWWP domain


    GLYR1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GLYR1_HUMAN, Q49A26
    Function: May have oxidoreductase activity. Regulates p38 MAP kinase activity by mediating stress activation of
    p38alpha/MAPK14 and specifically regulating MAPK14 signaling. Indirectly promotes phosphorylation of MAPK14 and
    activation of ATF2. The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6. Recruited on
    chromatin, recognizes and binds trimethylated 'Lys-36' of histone H3 (H3K36me3)

         Enzyme Number (IUBMB): EC 1.-.-.-1

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0004616phosphogluconate dehydrogenase (decarboxylating) activity IEA--
    GO:0016491oxidoreductase activity ----
    GO:0035064methylated histone residue binding IDA--
    GO:0050662coenzyme binding IEA--
         
    GLYR1 for ontologies           About GeneDecksing


    Animal Models:
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    miRTarBase miRNAs that target GLYR1:
    hsa-mir-221-3p (MIRT046910), hsa-mir-24-3p (MIRT030400), hsa-mir-877-3p (MIRT037154)

    Block miRNA regulation of human, mouse, rat GLYR1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GLYR1 (see all 75):
    hsa-miR-124* hsa-miR-26a-2* hsa-miR-607 hsa-miR-605 hsa-miR-578 hsa-miR-4267 hsa-miR-629* hsa-miR-208b
    SwitchGear 3'UTR luciferase reporter plasmidGLYR1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat GLYR1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GLYR1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GLYR1_HUMAN, Q49A26: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    endoplasmic reticulum1
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005794Golgi apparatus IDA--

    GLYR1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GLYR1
    Interactions:

        Search GeneGlobe Interaction Network for GLYR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for GLYR1 (Q49A262, 3 ENSP000003227164) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AICDAQ9GZX73, ENSP000002293354I2D: score=1 STRING: ENSP00000229335
    ESR1P033723, ENSP000002062494I2D: score=1 STRING: ENSP00000206249
    UBE2E2Q96LR53I2D: score=5 
    UBCENSP000003448184STRING: ENSP00000344818
    SUMO2ENSP000004059654STRING: ENSP00000405965
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006098pentose-phosphate shunt IEA--
    GO:0055114oxidation-reduction process ----

    GLYR1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GLYR1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for GLYR1 gene: 
    NM_032569.3  

    Unigene Cluster for GLYR1:

    Glyoxylate reductase 1 homolog (Arabidopsis)
    Hs.387255  [show with all ESTs]
    Unigene Representative Sequence: NM_032569
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000589389 ENST00000588732 ENST00000436648 ENST00000321919(uc002cxx.4 uc002cxy.3 uc002cya.2 uc010uxv.1)
    ENST00000587936 ENST00000591451 ENST00000591846 ENST00000588297 ENST00000586095
    ENST00000587297 ENST00000586901 ENST00000587875 ENST00000591159 ENST00000381983(uc002cxz.1)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate GLYR1 (see all 75):
    hsa-miR-124* hsa-miR-26a-2* hsa-miR-607 hsa-miR-605 hsa-miR-578 hsa-miR-4267 hsa-miR-629* hsa-miR-208b
    SwitchGear 3'UTR luciferase reporter plasmidGLYR1 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat GLYR1
      QuantiFast Probe-based Assays in human, mouse, rat GLYR1

    Additional mRNA sequence: 

    AF217521.1 AF244907.1 AF326966.1 AK096730.1 AK296842.1 AK307834.1 AY352585.1 BC003693.1 
    BC022809.1 BC032855.1 BC047223.1 BC048291.1 BC063039.1 BC064940.1 BC073868.1 CR933687.1 

    19 DOTS entries:

    DT.97820255  DT.455865  DT.120704602  DT.97781123  DT.40107533  DT.97854573  DT.97854571  DT.99936178 
    DT.95335108  DT.92424029  DT.100798579  DT.100798583  DT.91741097  DT.91875664  DT.91884444  DT.92424028 
    DT.95202224  DT.97764065  DT.91881931 

    Selected AceView cDNA sequences (see all 521):

    AI336225 BM710054 BU733176 AA156866 BX331741 AI478491 BG013932 BQ641584 
    AI679628 AI222506 BI492801 BM728680 BC048291 AA480226 AI276588 BM931710 
    BE049457 AI521280 BM671209 BC071698 CB139232 AA453238 BG741814 AK098348 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for GLYR1 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19
    SP1:              -     -     -                 -                                                                                                               
    SP2:              -     -     -                 -                                                     -                                                         
    SP3:              -     -     -                 -                                   -                                                                           
    SP4:                                            -                                                                                                               
    SP5:              -           -                 -                                                                                                               


    ECgene alternative splicing isoforms for GLYR1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GLYR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTTTGTGCA
    GLYR1 Expression
    About this image


    GLYR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             XY Germ Cells Testis Cord
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Gonad
             XY Germ Cells Testis Cord
    GLYR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GLYR1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.387255
        Custom PCR Arrays for GLYR1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GLYR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for GLYR1 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Glyr11 , 5 glyoxylate reductase 1 homolog (Arabidopsis)1, 5 92.87(n)1
    98.73(a)1
      16 (2.49 cM)5
    740221  NM_001079814.11  NP_001073282.11 
     50139065 
    chicken
    (Gallus gallus)
    Aves GLYR11 glyoxylate reductase 1 homolog (Arabidopsis) 83.06(n)
    94.39(a)
      426988  NM_001006572.1  NP_001006572.1 
    lizard
    (Anolis carolinensis)
    Reptilia GLYR16
    glyoxylate reductase 1 homolog (Arabidopsis)
    90(a)
    1 ↔ 1
    GL343263.1(1302602-1324099)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia glyr11 glyoxylate reductase 1 homolog 73.66(n)
    83.36(a)
      595057  NM_001030494.1  NP_001025665.1 
    zebrafish
    (Danio rerio)
    Actinopterygii glyr11 glyoxylate reductase 1 homolog (Arabidopsis) 73.93(n)
    85.62(a)
      493611  NM_001007771.1  NP_001007772.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG47471 CG4747 47.07(n)
    35.58(a)
      192507  NM_001201838.1  NP_001188767.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons GLYR11 GLYR1 52.25(n)
    49.65(a)
      822139  NM_113449.3  NP_566768.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g05627001 Os02g0562700 55.63(n)
    51.96(a)
      4329690  NM_001053689.1  NP_001047154.1 


    ENSEMBL Gene Tree for GLYR1 (if available)
    TreeFam Gene Tree for GLYR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GLYR1 gene
    HIBADH2  
    2 SIMAP similar genes for GLYR1 using alignment to 6 protein entries:     GLYR1_HUMAN (see all proteins):
    N-PAC    HDGFRP2

    GLYR1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for GLYR1
    PGOHUM00000247669


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GLYR1 (see all 1219)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1175810211,2
    C,F--4855048(+) CACTTG/CTCCCC 1 -- ut311Minor allele frequency- C:0.02NA 120
    rs1913828601,2
    --4855077(+) GAAGGA/GTGCTG 1 -- ut310--------
    rs1846348261,2
    --4855136(+) GGAGAC/TAGGTG 1 -- ut310--------
    rs2003564751,2
    C--4855230(+) GGTGTC/TGACAG 1 -- ut310--------
    rs1381963151,2
    C--4855258(+) CGGTAC/GACGGC 2 V syn10--------
    rs80640241,2
    C,F,A,H--4855279(+) TTGTCG/AGACTG 2 /S syn138Minor allele frequency- A:0.43MN NA NS EA WA CSA EU 9368
    rs177031111,2,,4
    C,H--4855307(+) TTTTGT/CACACC 2 /Y /C mis1 ese38Minor allele frequency- C:0.00NA NS EA 544
    rs794518381,2
    C,F--4855435(+) GGTTAG/CGAATC 1 -- int11Minor allele frequency- C:0.02WA 118
    rs1148843191,2
    C,F--4855461(+) ATGAAG/TCACCT 1 -- int11Minor allele frequency- T:0.03WA 118
    rs785494001,2
    C,F--4855500(+) TTCTTG/ACTCTG 1 -- int11Minor allele frequency- A:0.04WA 118

    HapMap Linkage Disequilibrium report for GLYR1 (4853204 - 4897343 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for GLYR1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422516CNV Deletion17116639
    esv2676130CNV Deletion23128226
    esv2659144CNV Deletion23128226
    nsv905251CNV Loss21882294
    nsv905248CNV Loss21882294
    nsv905250CNV Loss21882294
    nsv510674CNV Loss20534489
    dgv2589n71CNV Loss21882294
    esv26756CNV Gain+Loss19812545

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610660    OMIM disorders: --

    12 diseases for GLYR1:    
    About MalaCards
    band keratopathy    nasopharynx carcinoma    keratopathy    listeriosis
    tonsillitis    tuberculosis    thyroiditis    malaria
    cerebritis    breast cancer    endotheliitis    prostatitis

    1 disease from the University of Copenhagen DISEASES database for GLYR1:
    Band keratopathy

    GLYR1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): GLYR1

    Export disorders for GLYR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GLYR1 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with GLYR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Nuclear protein NP60 regulates p38 MAPK activity. (PubMed id 16352664)1, 2, 3 Fu J.... Gu J. (J. Cell Sci. 2006)
    2. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
    3. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    4. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    5. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    6. Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C.... Cristea I.M. (Mol. Cell. Proteomics 2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84656 HGNC: 24434 AceView: FLJ22386andN-PAC Ensembl:ENSG00000140632 euGenes: HUgn84656
    ECgene: GLYR1 H-InvDB: GLYR1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GLYR1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GLYR1 gene:
    Search GeneIP for patents involving GLYR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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