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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GLYR1 Gene

protein-coding   GIFtS: 48
GCID: GC16M004855

Glyoxylate Reductase 1 Homolog (Arabidopsis)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Glyoxylate Reductase 1 Homolog (Arabidopsis)1 2     HIBDL2 3
NP602 3 5     BM0452
Nuclear Protein 60kDa1 2     N-PAC2
Cytokine-Like Nuclear Factor N-PAC2 3     Nuclear Protein 60 KDa2
Nuclear Protein NP602 3     Putative Oxidoreductase GLYR12
Nuclear Protein Of 60 KDa2 3     EC 1.-.-.-3
3-Hydroxyisobutyrate Dehydrogenase-Like Protein2 3     Glyoxylate Reductase 1 Homolog3

External Ids:    HGNC: 244341   Entrez Gene: 846562   Ensembl: ENSG000001406327   OMIM: 6106605   UniProtKB: Q49A263   

Export aliases for GLYR1 gene to outside databases

Previous GC identifer: GC16M004794


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for GLYR1 Gene: 
GLYR1 (glyoxylate reductase 1 homolog (Arabidopsis)) is a protein-coding gene. Diseases associated with GLYR1 include band keratopathy, and nasopharynx carcinoma. GO annotations related to this gene include coenzyme binding and nucleotide binding. An important paralog of this gene is HIBADH.

UniProtKB/Swiss-Prot: GLYR1_HUMAN, Q49A26
Function: May have oxidoreductase activity. Regulates p38 MAP kinase activity by mediating stress activation of
p38alpha/MAPK14 and specifically regulating MAPK14 signaling. Indirectly promotes phosphorylation of MAPK14 and
activation of ATF2. The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6. Recruited on
chromatin, recognizes and binds trimethylated 'Lys-36' of histone H3 (H3K36me3)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010393.16  NC_018927.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for GLYR1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGLYR1 promoter sequence
   Search SABiosciences Chromatin IP Primers for GLYR1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GLYR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

GLYR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GLYR1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M004855:  view genomic region     (about GC identifiers)

Start:
4,853,204 bp from pter      End:
4,897,343 bp from pter
Size:
44,140 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GLYR1_HUMAN, Q49A26 (See protein sequence)
Recommended Name: Putative oxidoreductase GLYR1  
Size: 553 amino acids; 60556 Da
Subunit: Interacts with MAPK14
Subcellular location: Nucleus
Miscellaneous: The conserved NAD-binding sites and sequence similarity to plant dehydrogenases suggest that this
protein may have oxidoreductase activity
6 PDB 3D structures from and Proteopedia for GLYR1:
2UYY (3D)        4GUR (3D)        4GUS (3D)        4GUT (3D)        4GUU (3D)        4HSU (3D)    
Secondary accessions: B4DL47 C9JJ40 C9JJ60 Q5U632 Q6P1Q2 Q6V3W7 Q9BTI1 Q9BXK2
Alternative splicing: 5 isoforms:  Q49A26-1   Q49A26-2   Q49A26-5   Q49A26-3   Q49A26-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for GLYR1: NX_Q49A26

Explore proteomics data for GLYR1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q49A26

  • GLYR1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GLYR1 Protein Expression
    REFSEQ proteins: NP_115958.2  
    ENSEMBL proteins: 
     ENSP00000466570   ENSP00000466127   ENSP00000390276   ENSP00000322716   ENSP00000465490  
     ENSP00000468328   ENSP00000467751   ENSP00000467541   ENSP00000371413  

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    Novus Biologicals GLYR1 Lysates
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for GLYR1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    GLYR1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/7 InterPro protein domains (see all 7):
     IPR006115 6PGDH_NADP-bd
     IPR017956 AT_hook_DNA-bd_motif
     IPR008927 6-PGluconate_DH_C-like
     IPR015815 HIBADH-type
     IPR013328 DH_multihelical

    Graphical View of Domain Structure for InterPro Entry Q49A26

    ProtoNet protein and cluster: Q49A26

    2 Blocks protein domains:
    IPB000313 PWWP domain
    IPB002204 3-hydroxyisobutyrate dehydrogenase


    UniProtKB/Swiss-Prot: GLYR1_HUMAN, Q49A26
    Domain: The A.T hook DNA-binding domain is required for the interaction with MAPK14
    Domain: The PWWP domain probably mediates the binding to H3K36me3
    Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family. NP60 subfamily
    Similarity: Contains 1 A.T hook DNA-binding domain
    Similarity: Contains 1 PWWP domain


    GLYR1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GLYR1_HUMAN, Q49A26
    Function: May have oxidoreductase activity. Regulates p38 MAP kinase activity by mediating stress activation of
    p38alpha/MAPK14 and specifically regulating MAPK14 signaling. Indirectly promotes phosphorylation of MAPK14 and
    activation of ATF2. The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6. Recruited on
    chromatin, recognizes and binds trimethylated 'Lys-36' of histone H3 (H3K36me3)

         Enzyme Number (IUBMB): EC 1.-.-.-1

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0004616phosphogluconate dehydrogenase (decarboxylating) activity IEA--
    GO:0016491oxidoreductase activity ----
    GO:0035064methylated histone residue binding IDA--
    GO:0050662coenzyme binding IEA--
         
    GLYR1 for ontologies           About GeneDecksing


    Animal Models:
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    hsa-miR-124* hsa-miR-26a-2* hsa-miR-607 hsa-miR-605 hsa-miR-578 hsa-miR-4267 hsa-miR-629* hsa-miR-208b
    SwitchGear 3'UTR luciferase reporter plasmidGLYR1 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GLYR1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GLYR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/9 Interacting proteins for GLYR1 (Q49A262, 3 ENSP000003227164) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AICDAQ9GZX73, ENSP000002293354I2D: score=1 STRING: ENSP00000229335
    ESR1P033723, ENSP000002062494I2D: score=1 STRING: ENSP00000206249
    UBE2E2Q96LR53I2D: score=5 
    UBCENSP000003448184STRING: ENSP00000344818
    SUMO2ENSP000004059654STRING: ENSP00000405965
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006098pentose-phosphate shunt IEA--
    GO:0055114oxidation-reduction process ----

    GLYR1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GLYR1

    Search CenterWatch for drugs/clinical trials and news about GLYR1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GLYR1 gene: 
    NM_032569.3  

    Unigene Cluster for GLYR1:

    Glyoxylate reductase 1 homolog (Arabidopsis)
    Hs.387255  [show with all ESTs]
    Unigene Representative Sequence: NM_032569
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000589389 ENST00000588732 ENST00000436648 ENST00000321919(uc002cxx.4 uc002cxy.3 uc002cya.2 uc010uxv.1)
    ENST00000587936 ENST00000591451 ENST00000591846 ENST00000588297 ENST00000586095
    ENST00000587297 ENST00000586901 ENST00000587875 ENST00000591159 ENST00000381983(uc002cxz.1)

    miRNA
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    8/75 QIAGEN miScript miRNA Assays for microRNAs that regulate GLYR1 (see all 75):
    hsa-miR-124* hsa-miR-26a-2* hsa-miR-607 hsa-miR-605 hsa-miR-578 hsa-miR-4267 hsa-miR-629* hsa-miR-208b
    SwitchGear 3'UTR luciferase reporter plasmidGLYR1 3' UTR sequence
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GLYR1
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GLYR1

    Additional mRNA sequence: 

    AF217521.1 AF244907.1 AF326966.1 AK096730.1 AK296842.1 AK307834.1 AY352585.1 BC003693.1 
    BC022809.1 BC032855.1 BC047223.1 BC048291.1 BC063039.1 BC064940.1 BC073868.1 CR933687.1 

    19 DOTS entries:

    DT.97820255  DT.455865  DT.120704602  DT.97781123  DT.40107533  DT.97854573  DT.97854571  DT.99936178 
    DT.95335108  DT.92424029  DT.100798579  DT.100798583  DT.91741097  DT.91875664  DT.91884444  DT.92424028 
    DT.95202224  DT.97764065  DT.91881931 

    24/521 AceView cDNA sequences (see all 521):

    BM467995 BM503391 AA348753 BI492801 BE855579 CA429512 BM454630 CK725160 
    BI518431 AW615417 AI401496 AI186368 BE503523 BQ720854 BM709107 BM710054 
    BM663291 AK096730 BM142098 F10824 CF127496 CB529066 BG013932 BC071698 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for GLYR1 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19
    SP1:              -     -     -                 -                                                                                                               
    SP2:              -     -     -                 -                                                     -                                                         
    SP3:              -     -     -                 -                                   -                                                                           
    SP4:                                            -                                                                                                               
    SP5:              -           -                 -                                                                                                               


    ECgene alternative splicing isoforms for GLYR1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GLYR1 expression in normal human tissues (normalized intensities)      GLYR1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTTTGTGCA
    GLYR1 Expression
    About this image


    GLYR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/34 selected tissues (see all 34) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 5 entries
             XY Germ Cells Testis Cord
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex

    See GLYR1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GLYR1

    SOURCE GeneReport for Unigene cluster: Hs.387255
        SABiosciences Custom PCR Arrays for GLYR1
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GLYR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for GLYR1 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Glyr11 , 5 glyoxylate reductase 1 homolog (Arabidopsis)1, 5 92.87(n)1
    98.73(a)1
      16 (2.49 cM)5
    740221  NM_001079814.11  NP_001073282.11 
     50139065 
    chicken
    (Gallus gallus)
    Aves GLYR11 glyoxylate reductase 1 homolog (Arabidopsis) 83.06(n)
    94.39(a)
      426988  NM_001006572.1  NP_001006572.1 
    lizard
    (Anolis carolinensis)
    Reptilia GLYR16
    Uncharacterized protein
    90(a)
    1 ↔ 1
    GL343263.1(1302602-1324099)
    zebrafish
    (Danio rerio)
    Actinopterygii glyr11 glyoxylate reductase 1 homolog (Arabidopsis) 74.27(n)
    86.93(a)
      493611  NM_001007771.1  NP_001007772.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG47471 CG4747 46.85(n)
    34.95(a)
      192507  NM_001201838.1  NP_001188767.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons GLYR11 glyoxylate reductase 1 52.25(n)
    49.65(a)
      822139  NM_113449.3  NP_566768.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g05627001 hypothetical protein 55.83(n)
    52.14(a)
      4329690  NM_001053689.1  NP_001047154.1 


    ENSEMBL Gene Tree for GLYR1 (if available)
    TreeFam Gene Tree for GLYR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GLYR1 gene
    HIBADH2  
    2 SIMAP similar genes for GLYR1 using alignment to 6 protein entries:     GLYR1_HUMAN (see all proteins):
    N-PAC    HDGFRP2

    GLYR1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for GLYR1
    PGOHUM00000247669


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1219 SNPs in GLYR1 are shown (see all 1219)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0374044
    ----see VAR_0374042 H Q mis40--------
    rs1175810211,2
    C,F--4855048(+) CACTTG/CTCCCC 1 -- ut311Minor allele frequency- C:0.02NA 120
    rs1913828601,2
    --4855077(+) GAAGGA/GTGCTG 1 -- ut310--------
    rs1846348261,2
    --4855136(+) GGAGAC/TAGGTG 1 -- ut310--------
    rs2003564751,2
    C--4855230(+) GGTGTC/TGACAG 1 -- ut310--------
    rs1381963151,2
    C--4855258(+) CGGTAC/GACGGC 2 V syn10--------
    rs80640241,2
    C,F,A,H--4855279(+) TTGTCG/AGACTG 2 /S syn138Minor allele frequency- A:0.43MN NA NS EA WA CSA EU 9368
    rs177031111,2,4
    C,H--4855307(+) TTTTGT/CACACC 2 /Y /C mis1 ese38Minor allele frequency- C:0.00NA NS EA 544
    rs794518381,2
    C,F--4855435(+) GGTTAG/CGAATC 1 -- int11Minor allele frequency- C:0.02WA 118
    rs1148843191,2
    C,F--4855461(+) ATGAAG/TCACCT 1 -- int11Minor allele frequency- T:0.03WA 118

    HapMap Linkage Disequilibrium report for GLYR1 (4853204 - 4897343 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for GLYR1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2422516CNV Deletion17116639
    esv2676130CNV Deletion23128226
    esv2659144CNV Deletion23128226
    nsv905251CNV Loss21882294
    nsv905248CNV Loss21882294
    nsv905250CNV Loss21882294
    nsv510674CNV Loss20534489
    dgv2589n71CNV Loss21882294
    esv26756CNV Gain+Loss19812545

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610660    OMIM disorders: --

    6 diseases for GLYR1:    About MalaCards
    band keratopathy    nasopharynx carcinoma    listeriosis    keratopathy
    tuberculosis    breast cancer

    1 disease from the University of Copenhagen DISEASES database for GLYR1:
    Band keratopathy

    GLYR1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): GLYR1

    Export disorders for GLYR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GLYR1 gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with GLYR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Nuclear protein NP60 regulates p38 MAPK activity. (PubMed id 16352664)1, 2, 3 Fu J.... Gu J. (2006)
    2. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (2013)
    3. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    4. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    5. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    6. Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84656 HGNC: 24434 AceView: FLJ22386andN-PAC Ensembl:ENSG00000140632 euGenes: HUgn84656
    ECgene: GLYR1 H-InvDB: GLYR1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GLYR1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GLYR1 gene:
    Search GeneIP for patents involving GLYR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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