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Aliases for GLYR1 Gene

Aliases for GLYR1 Gene

  • Glyoxylate Reductase 1 Homolog (Arabidopsis) 2 3
  • NP60 3 4 6
  • 3-Hydroxyisobutyrate Dehydrogenase-Like Protein 3 4
  • Nuclear Protein Of 60 KDa 3 4
  • Nuclear Protein 60kDa 2 3
  • Nuclear Protein NP60 3 4
  • HIBDL 3 4
  • Cytokine-Like Nuclear Factor N-Pac 3
  • Cytokine-Like Nuclear Factor N-PAC 4
  • Glyoxylate Reductase 1 Homolog 4
  • Putative Oxidoreductase GLYR1 3
  • Nuclear Protein 60 KDa 3
  • EC 1.-.-.- 4
  • BM045 3
  • N-PAC 3

External Ids for GLYR1 Gene

Previous GeneCards Identifiers for GLYR1 Gene

  • GC16M004794
  • GC16M004855

Summaries for GLYR1 Gene

GeneCards Summary for GLYR1 Gene

GLYR1 (Glyoxylate Reductase 1 Homolog (Arabidopsis)) is a Protein Coding gene. Diseases associated with GLYR1 include band keratopathy. GO annotations related to this gene include methylated histone binding and phosphogluconate dehydrogenase (decarboxylating) activity. An important paralog of this gene is HIBADH.

UniProtKB/Swiss-Prot for GLYR1 Gene

  • May have oxidoreductase activity. Regulates p38 MAP kinase activity by mediating stress activation of p38alpha/MAPK14 and specifically regulating MAPK14 signaling. Indirectly promotes phosphorylation of MAPK14 and activation of ATF2. The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6. Recruited on chromatin, recognizes and binds trimethylated Lys-36 of histone H3 (H3K36me3).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLYR1 Gene

Genomics for GLYR1 Gene

Genomic Location for GLYR1 Gene

Start:
4,803,203 bp from pter
End:
4,847,382 bp from pter
Size:
44,180 bases
Orientation:
Minus strand

Genomic View for GLYR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GLYR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLYR1 Gene

No data available for Regulatory Elements for GLYR1 Gene

Proteins for GLYR1 Gene

  • Protein details for GLYR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q49A26-GLYR1_HUMAN
    Recommended name:
    Putative oxidoreductase GLYR1
    Protein Accession:
    Q49A26
    Secondary Accessions:
    • B4DL47
    • C9JJ40
    • C9JJ60
    • Q5U632
    • Q6P1Q2
    • Q6V3W7
    • Q9BTI1
    • Q9BXK2

    Protein attributes for GLYR1 Gene

    Size:
    553 amino acids
    Molecular mass:
    60556 Da
    Quaternary structure:
    • Interacts with MAPK14.
    Miscellaneous:
    • The conserved NAD-binding sites and sequence similarity to plant dehydrogenases suggest that this protein may have oxidoreductase activity

    Three dimensional structures from OCA and Proteopedia for GLYR1 Gene

    Alternative splice isoforms for GLYR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GLYR1 Gene

Proteomics data for GLYR1 Gene at MOPED

Post-translational modifications for GLYR1 Gene

  • Ubiquitination at Lys211, Lys335, Lys338, Lys495, Lys532, and Lys535
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GLYR1 Gene

Domains for GLYR1 Gene

Suggested Antigen Peptide Sequences for GLYR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q49A26

UniProtKB/Swiss-Prot:

GLYR1_HUMAN :
  • Q49A26
Domain:
  • The A.T hook DNA-binding domain is required for the interaction with MAPK14
  • The PWWP domain probably mediates the binding to H3K36me3
  • Contains 1 A.T hook DNA-binding domain.
  • Contains 1 PWWP domain.
Family:
  • Belongs to the 3-hydroxyisobutyrate dehydrogenase family. NP60 subfamily.
genes like me logo Genes that share domains with GLYR1: view

No data available for Gene Families for GLYR1 Gene

Function for GLYR1 Gene

Molecular function for GLYR1 Gene

UniProtKB/Swiss-Prot Function: May have oxidoreductase activity. Regulates p38 MAP kinase activity by mediating stress activation of p38alpha/MAPK14 and specifically regulating MAPK14 signaling. Indirectly promotes phosphorylation of MAPK14 and activation of ATF2. The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6. Recruited on chromatin, recognizes and binds trimethylated Lys-36 of histone H3 (H3K36me3).

Enzyme Numbers (IUBMB) for GLYR1 Gene

Gene Ontology (GO) - Molecular Function for GLYR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0035064 methylated histone binding IDA 20850016
GO:0051287 NAD binding IEA --
genes like me logo Genes that share ontologies with GLYR1: view

miRNA for GLYR1 Gene

miRTarBase miRNAs that target GLYR1

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for GLYR1 Gene

Localization for GLYR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLYR1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GLYR1 Gene COMPARTMENTS Subcellular localization image for GLYR1 gene
Compartment Confidence
nucleus 5
cytosol 2
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for GLYR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with GLYR1: view

Pathways for GLYR1 Gene

SuperPathways for GLYR1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GLYR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006098 pentose-phosphate shunt IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with GLYR1: view

No data available for Pathways by source for GLYR1 Gene

Transcripts for GLYR1 Gene

Unigene Clusters for GLYR1 Gene

Glyoxylate reductase 1 homolog (Arabidopsis):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GLYR1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19
SP1: - - - -
SP2: - - - - -
SP3: - - - - -
SP4: -
SP5: - - -
SP6: - - -
SP7:
SP8: -

Relevant External Links for GLYR1 Gene

GeneLoc Exon Structure for
GLYR1
ECgene alternative splicing isoforms for
GLYR1

Expression for GLYR1 Gene

mRNA expression in normal human tissues for GLYR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for GLYR1 Gene

SOURCE GeneReport for Unigene cluster for GLYR1 Gene Hs.387255

genes like me logo Genes that share expressions with GLYR1: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GLYR1 Gene

Orthologs for GLYR1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GLYR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GLYR1 35
  • 99.1 (n)
  • 98.75 (a)
GLYR1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GLYR1 35
  • 92.89 (n)
  • 98.37 (a)
GLYR1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GLYR1 35
  • 94.03 (n)
  • 99.46 (a)
GLYR1 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Glyr1 35
  • 92.87 (n)
  • 98.73 (a)
Glyr1 16
Glyr1 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GLYR1 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GLYR1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Glyr1 35
  • 92.39 (n)
  • 98.91 (a)
chicken
(Gallus gallus)
Aves GLYR1 35
  • 83.06 (n)
  • 94.39 (a)
GLYR1 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GLYR1 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia glyr1 35
  • 73.66 (n)
  • 83.36 (a)
zebrafish
(Danio rerio)
Actinopterygii glyr1 35
  • 73.93 (n)
  • 85.62 (a)
glyr1 36
  • 79 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta GLYR1_ANOGA 35
  • 46.18 (n)
  • 36.26 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4747 35
  • 47.07 (n)
  • 35.58 (a)
CG4747 36
  • 23 (a)
OneToOne
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7476 35
thale cress
(Arabidopsis thaliana)
eudicotyledons GLYR1 35
  • 52.25 (n)
  • 49.65 (a)
rice
(Oryza sativa)
Liliopsida Os02g0562700 35
  • 55.63 (n)
  • 51.96 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8517 36
  • 54 (a)
OneToOne
Species with no ortholog for GLYR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GLYR1 Gene

ENSEMBL:
Gene Tree for GLYR1 (if available)
TreeFam:
Gene Tree for GLYR1 (if available)

Paralogs for GLYR1 Gene

Paralogs for GLYR1 Gene

Selected SIMAP similar genes for GLYR1 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for GLYR1 Gene

genes like me logo Genes that share paralogs with GLYR1: view

Variants for GLYR1 Gene

Sequence variations from dbSNP and Humsavar for GLYR1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs741692 -- 4,812,424(+) ATGTG(C/T)AGGTC intron-variant
rs930854 -- 4,814,100(+) AGAAT(A/G)AACCT intron-variant
rs930855 -- 4,814,178(+) CTACC(A/G)CACTT intron-variant
rs1001157 -- 4,820,632(-) TGATA(C/T)TTTTG intron-variant
rs1005227 -- 4,819,248(+) tatca(A/G)gcaat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GLYR1 Gene

Variant ID Type Subtype PubMed ID
dgv2589n71 CNV Loss 21882294
nsv905248 CNV Loss 21882294
nsv905250 CNV Loss 21882294
esv26756 CNV Gain+Loss 19812545
esv2422516 CNV Deletion 17116639
nsv905251 CNV Loss 21882294
esv2676130 CNV Deletion 23128226
esv2659144 CNV Deletion 23128226
nsv510674 CNV Loss 20534489

Relevant External Links for GLYR1 Gene

HapMap Linkage Disequilibrium report
GLYR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLYR1 Gene

Disorders for GLYR1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for GLYR1 Gene including...

Search for GLYR1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for GLYR1 Gene

Relevant External Links for GLYR1

Genetic Association Database (GAD)
GLYR1
genes like me logo Genes that share disorders with GLYR1: view

No data available for UniProtKB/Swiss-Prot for GLYR1 Gene

Publications for GLYR1 Gene

  1. Nuclear protein NP60 regulates p38 MAPK activity. (PMID: 16352664) Fu J. … Gu J. (J. Cell Sci. 2006) 2 3 4
  2. Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers. (PMID: 20850016) Vermeulen M. … Mann M. (Cell 2010) 3 4
  3. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3
  4. Identification of proteins associated with ligand-activated estrogen receptor I+ in human breast cancer cell nuclei by tandem affinity purification and nano LC-MS/MS. (PMID: 21182205) Tarallo R. … Weisz A. (Proteomics 2011) 3
  5. Comparative proteomic analysis identifies a role for SUMO in protein quality control. (PMID: 21693764) Tatham M.H. … Hay R.T. (Sci Signal 2011) 3

Products for GLYR1 Gene

Sources for GLYR1 Gene

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