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Aliases for GLYR1 Gene

Aliases for GLYR1 Gene

  • Glyoxylate Reductase 1 Homolog 2 3 4 5
  • 3-Hydroxyisobutyrate Dehydrogenase-Like Protein 3 4
  • Nuclear Protein Of 60 KDa 3 4
  • Nuclear Protein 60kDa 2 3
  • Nuclear Protein NP60 3 4
  • HIBDL 3 4
  • NP60 3 4
  • Glyoxylate Reductase 1 Homolog (Arabidopsis) 2
  • Cytokine-Like Nuclear Factor N-Pac 3
  • Cytokine-Like Nuclear Factor N-PAC 4
  • Putative Oxidoreductase GLYR1 3
  • Nuclear Protein 60 KDa 3
  • EC 1.-.-.- 4
  • BM045 3
  • N-PAC 3

External Ids for GLYR1 Gene

Previous GeneCards Identifiers for GLYR1 Gene

  • GC16M004794
  • GC16M004855

Summaries for GLYR1 Gene

GeneCards Summary for GLYR1 Gene

GLYR1 (Glyoxylate Reductase 1 Homolog) is a Protein Coding gene. GO annotations related to this gene include methylated histone binding and phosphogluconate dehydrogenase (decarboxylating) activity. An important paralog of this gene is HIBADH.

UniProtKB/Swiss-Prot for GLYR1 Gene

  • May have oxidoreductase activity. Regulates p38 MAP kinase activity by mediating stress activation of p38alpha/MAPK14 and specifically regulating MAPK14 signaling. Indirectly promotes phosphorylation of MAPK14 and activation of ATF2. The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6. Recruited on chromatin, recognizes and binds trimethylated Lys-36 of histone H3 (H3K36me3).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLYR1 Gene

Genomics for GLYR1 Gene

Regulatory Elements for GLYR1 Gene

Enhancers for GLYR1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F004894 1.1 FANTOM5 16.1 -47.6 -47627 0.2 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 FOS SP3 SP5 MXD4 LOC105371067 ENSG00000261789 LOC105371066 GLYR1 LINC01570 PPL UBN1 ENSG00000261442 C16orf96 SEPT12
GH16F004765 1.5 FANTOM5 ENCODE 10.7 +79.9 79880 4.2 HDGF CREB3L1 MLX ZFP64 ARID4B SIN3A YBX1 DMAP1 ZNF2 YY1 VASN SEPT12 ROGDI C16orf71 ANKS3 ZNF500 GLYR1 UBN1 SMIM22 SEC14L5
GH16F004918 1 Ensembl ENCODE 15.8 -71.7 -71748 1.5 MAZ ZNF687 PKNOX1 ZHX2 SIN3A MNT NR3C1 DPF2 ZIC2 GATA3 SEPT12 GLYR1 PPL UBN1 ZNF500 GC16P004899 GC16M004952
GH16F004914 0.9 Ensembl ENCODE 15.9 -68.2 -68182 1.6 BCOR MIER1 BHLHE40 ZMYM3 ELF1 ZIC2 ZNF7 ZGPAT ZNF239 FOS GLYR1 PPL UBN1 ZNF500 SEPT12 GC16P004899 GC16M004952
GH16F004892 1.2 Ensembl ENCODE 11.6 -45.3 -45346 1.1 PKNOX1 CBX3 MLX SIN3A DNMT3B ZNF48 SLC30A9 FOS RCOR1 ZNF263 PPL GLYR1 UBN1 SEPT12 PIR34804 LOC105371064
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GLYR1 on UCSC Golden Path with GeneCards custom track

Genomic Location for GLYR1 Gene

Chromosome:
16
Start:
4,803,203 bp from pter
End:
4,847,342 bp from pter
Size:
44,140 bases
Orientation:
Minus strand

Genomic View for GLYR1 Gene

Genes around GLYR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GLYR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GLYR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLYR1 Gene

Proteins for GLYR1 Gene

  • Protein details for GLYR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q49A26-GLYR1_HUMAN
    Recommended name:
    Putative oxidoreductase GLYR1
    Protein Accession:
    Q49A26
    Secondary Accessions:
    • B4DL47
    • C9JJ40
    • C9JJ60
    • Q5U632
    • Q6P1Q2
    • Q6V3W7
    • Q9BTI1
    • Q9BXK2

    Protein attributes for GLYR1 Gene

    Size:
    553 amino acids
    Molecular mass:
    60556 Da
    Quaternary structure:
    • Interacts with MAPK14.
    Miscellaneous:
    • The conserved NAD-binding sites and sequence similarity to plant dehydrogenases suggest that this protein may have oxidoreductase activity.

    Three dimensional structures from OCA and Proteopedia for GLYR1 Gene

    Alternative splice isoforms for GLYR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GLYR1 Gene

Post-translational modifications for GLYR1 Gene

  • Ubiquitination at Lys 211, Lys 335, Lys 338, Lys 495, Lys 532, and Lys 535
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GLYR1 Gene

Domains & Families for GLYR1 Gene

Gene Families for GLYR1 Gene

Graphical View of Domain Structure for InterPro Entry

Q49A26

UniProtKB/Swiss-Prot:

GLYR1_HUMAN :
  • The A.T hook DNA-binding domain is required for the interaction with MAPK14.
  • Belongs to the 3-hydroxyisobutyrate dehydrogenase family. NP60 subfamily.
Domain:
  • The A.T hook DNA-binding domain is required for the interaction with MAPK14.
  • The PWWP domain probably mediates the binding to H3K36me3.
  • Contains 1 A.T hook DNA-binding domain.
  • Contains 1 PWWP domain.
Family:
  • Belongs to the 3-hydroxyisobutyrate dehydrogenase family. NP60 subfamily.
genes like me logo Genes that share domains with GLYR1: view

Function for GLYR1 Gene

Molecular function for GLYR1 Gene

UniProtKB/Swiss-Prot Function:
May have oxidoreductase activity. Regulates p38 MAP kinase activity by mediating stress activation of p38alpha/MAPK14 and specifically regulating MAPK14 signaling. Indirectly promotes phosphorylation of MAPK14 and activation of ATF2. The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6. Recruited on chromatin, recognizes and binds trimethylated Lys-36 of histone H3 (H3K36me3).

Enzyme Numbers (IUBMB) for GLYR1 Gene

Gene Ontology (GO) - Molecular Function for GLYR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity IEA --
GO:0005515 protein binding IPI 23260659
GO:0016491 oxidoreductase activity IEA --
GO:0035064 methylated histone binding IDA 20850016
genes like me logo Genes that share ontologies with GLYR1: view
genes like me logo Genes that share phenotypes with GLYR1: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GLYR1 Gene

Localization for GLYR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLYR1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GLYR1 gene
Compartment Confidence
nucleus 5
cytosol 5
golgi apparatus 5
mitochondrion 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for GLYR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000786 nucleosome IDA 23260659
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with GLYR1: view

Pathways & Interactions for GLYR1 Gene

SuperPathways for GLYR1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GLYR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with GLYR1: view

No data available for Pathways by source and SIGNOR curated interactions for GLYR1 Gene

Transcripts for GLYR1 Gene

Unigene Clusters for GLYR1 Gene

Glyoxylate reductase 1 homolog (Arabidopsis):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GLYR1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19
SP1: - - - -
SP2: - - - - -
SP3: - - - - -
SP4: -
SP5: - - -
SP6: - - -
SP7:
SP8: -

Relevant External Links for GLYR1 Gene

GeneLoc Exon Structure for
GLYR1
ECgene alternative splicing isoforms for
GLYR1

Expression for GLYR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GLYR1 Gene

Protein differential expression in normal tissues from HIPED for GLYR1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.0) and Blymphocyte (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GLYR1 Gene



Protein tissue co-expression partners for GLYR1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GLYR1 Gene:

GLYR1

SOURCE GeneReport for Unigene cluster for GLYR1 Gene:

Hs.387255
genes like me logo Genes that share expression patterns with GLYR1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GLYR1 Gene

Orthologs for GLYR1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GLYR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GLYR1 34 35
  • 99.1 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GLYR1 35
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GLYR1 35
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GLYR1 34 35
  • 94.03 (n)
cow
(Bos Taurus)
Mammalia GLYR1 34 35
  • 92.89 (n)
mouse
(Mus musculus)
Mammalia Glyr1 34 16 35
  • 92.87 (n)
rat
(Rattus norvegicus)
Mammalia Glyr1 34
  • 92.39 (n)
chicken
(Gallus gallus)
Aves GLYR1 34 35
  • 83.06 (n)
lizard
(Anolis carolinensis)
Reptilia GLYR1 35
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia glyr1 34
  • 73.66 (n)
zebrafish
(Danio rerio)
Actinopterygii glyr1 34 35
  • 73.93 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG4747 34 35
  • 47.07 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta GLYR1_ANOGA 34
  • 46.18 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons GLYR1 34
  • 52.25 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7476 34
rice
(Oryza sativa)
Liliopsida Os02g0562700 34
  • 55.63 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8517 35
  • 54 (a)
OneToOne
Species where no ortholog for GLYR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GLYR1 Gene

ENSEMBL:
Gene Tree for GLYR1 (if available)
TreeFam:
Gene Tree for GLYR1 (if available)

Paralogs for GLYR1 Gene

Paralogs for GLYR1 Gene

(2) SIMAP similar genes for GLYR1 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for GLYR1 Gene

genes like me logo Genes that share paralogs with GLYR1: view

Variants for GLYR1 Gene

Sequence variations from dbSNP and Humsavar for GLYR1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1001157 -- 4,820,632(-) TGATA(C/T)TTTTG intron-variant
rs1005227 -- 4,819,248(+) tatca(A/G)gcaat intron-variant
rs11076847 -- 4,810,740(+) TAGCC(A/G)GGCGT intron-variant
rs11076848 -- 4,811,015(+) CAGGA(A/G)AATTG intron-variant
rs11076849 -- 4,838,303(+) AGACC(G/T)GTCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GLYR1 Gene

Variant ID Type Subtype PubMed ID
nsv510674 CNV deletion 20534489
nsv1046986 CNV gain 25217958
esv3637709 CNV loss 21293372
esv3637708 CNV loss 21293372
esv3637707 CNV gain 21293372
esv3553047 CNV deletion 23714750
esv2676130 CNV deletion 23128226
esv26756 CNV gain+loss 19812545
esv2659144 CNV deletion 23128226
esv2422516 CNV deletion 17116639

Variation tolerance for GLYR1 Gene

Residual Variation Intolerance Score: 4.37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.81; 16.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GLYR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GLYR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLYR1 Gene

Disorders for GLYR1 Gene

Relevant External Links for GLYR1

Genetic Association Database (GAD)
GLYR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GLYR1

No disorders were found for GLYR1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GLYR1 Gene

Publications for GLYR1 Gene

  1. Nuclear protein NP60 regulates p38 MAPK activity. (PMID: 16352664) Fu J. … Gu J. (J. Cell Sci. 2006) 2 3 4 64
  2. Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers. (PMID: 20850016) Vermeulen M. … Mann M. (Cell 2010) 3 4 64
  3. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3 64
  4. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3 64
  5. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3 64

Products for GLYR1 Gene

Sources for GLYR1 Gene

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