Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GLYR1 Gene

protein-coding   GIFtS: 49
GCID: GC16M004855

glyoxylate reductase 1 homolog (Arabidopsis)

 Explore 7 diseases affiliated with
GLYR1 via our new
 Human Malady Compendium 
Biological research products
for GLYR1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Glyoxylate Reductase 1 Homolog (Arabidopsis)1 2     Nuclear Protein Of 60 KDa2 3
NP601 2 3 5     3-Hydroxyisobutyrate Dehydrogenase-Like Protein2 3
HIBDL1 2 3     Nuclear Protein 60 KDa2
BM0451 2     Nuclear Protein 60kDa2
N-PAC1 2     Putative Oxidoreductase GLYR12
Cytokine-Like Nuclear Factor N-PAC2 3     EC 1.-.-.-3
Nuclear Protein NP602 3     Glyoxylate Reductase 1 Homolog3

External Ids:    HGNC: 244341   Entrez Gene: 846562   Ensembl: ENSG000001406327   OMIM: 6106605   UniProtKB: Q49A263   

Export aliases for GLYR1 gene to outside databases

Previous GC identifer: GC16M004794


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: GLYR1_HUMAN, Q49A26
Function: May have oxidoreductase activity. Regulates p38 MAP kinase activity by mediating stress activation of
p38alpha/MAPK14 and specifically regulating MAPK14 signaling. Indirectly promotes phosphorylation of MAPK14 and
activation of ATF2. The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6. Recruited on
chromatin, recognizes and binds trimethylated 'Lys-36' of histone H3 (H3K36me3)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010393.16  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for GLYR1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGLYR1 promoter sequence
   Search SABiosciences Chromatin IP Primers for GLYR1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GLYR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

GLYR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GLYR1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M004855:  view genomic region     (about GC identifiers)

Start:
4,853,204 bp from pter      End:
4,897,343 bp from pter
Size:
44,140 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: GLYR1_HUMAN, Q49A26 (See protein sequence)
Recommended Name: Putative oxidoreductase GLYR1  
Size: 553 amino acids; 60556 Da
Subunit: Interacts with MAPK14
Subcellular location: Nucleus
Miscellaneous: The conserved NAD-binding sites and sequence similarity to plant dehydrogenases suggest that this
protein may have oxidoreductase activity
6 PDB 3D structures from and Proteopedia for GLYR1:
2UYY (3D)        4GUR (3D)        4GUS (3D)        4GUT (3D)        4GUU (3D)        4HSU (3D)    
Secondary accessions: B4DL47 C9JJ40 C9JJ60 Q5U632 Q6P1Q2 Q6V3W7 Q9BTI1 Q9BXK2
Alternative splicing: 5 isoforms:  Q49A26-1   Q49A26-2   Q49A26-5   Q49A26-3   Q49A26-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for GLYR1: NX_Q49A26

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q49A26

  • GLYR1 Protein expression data from MOPED and PaxDb:    About this image 
    GLYR1 Protein Expression
    REFSEQ proteins: NP_115958.2  
    ENSEMBL proteins: 
     ENSP00000466570   ENSP00000466127   ENSP00000390276   ENSP00000322716   ENSP00000465490  
     ENSP00000468328   ENSP00000467751   ENSP00000467541   ENSP00000371413  

    Human Recombinant Protein Products for GLYR1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: GLYR1
    OriGene Custom Protein Services for GLYR1 
    GenScript Custom Purified and Recombinant Proteins Services for GLYR1
    Novus Biologicals GLYR1 Protein
    Novus Biologicals GLYR1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for GLYR1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    GLYR1 for ontologies           About GeneDecksing



    GLYR1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for GLYR1 
    GenScript Custom Superior Antibodies Services for GLYR1
    Novus Biologicals GLYR1 Antibodies
    Search for Antibodies for GLYR1 at Abcam  
    Uscn Antibodies for GLYR1
    Search ThermoFisher Antibodies for GLYR1

    Assay Products for GLYR1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GLYR1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for GLYR1


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    GLYR1 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR006115 6PGDH_NADP-bd
     IPR017956 AT_hook_DNA-bd_motif
     IPR008927 6-PGluconate_DH_C-like
     IPR015815 HIBADH-type
     IPR013328 DH_multihelical

    Graphical View of Domain Structure for InterPro Entry Q49A26

    ProtoNet protein and cluster: Q49A26

    2 Blocks protein families:
    IPB000313 PWWP domain
    IPB002204 3-hydroxyisobutyrate dehydrogenase


    UniProtKB/Swiss-Prot: GLYR1_HUMAN, Q49A26
    Domain: The A.T hook DNA-binding domain is required for the interaction with MAPK14
    Domain: The PWWP domain probably mediates the binding to H3K36me3
    Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family. NP60 subfamily
    Similarity: Contains 1 A.T hook DNA-binding domain
    Similarity: Contains 1 PWWP domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GLYR1_HUMAN, Q49A26
    Function: May have oxidoreductase activity. Regulates p38 MAP kinase activity by mediating stress activation of
    p38alpha/MAPK14 and specifically regulating MAPK14 signaling. Indirectly promotes phosphorylation of MAPK14 and
    activation of ATF2. The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6. Recruited on
    chromatin, recognizes and binds trimethylated 'Lys-36' of histone H3 (H3K36me3)

         Enzyme Number (IUBMB): EC 1.-.-.-1

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003677DNA binding IEA--
    GO:0004616phosphogluconate dehydrogenase (decarboxylating) activity IEA--
    GO:0035064methylated histone residue binding IDA--
    GO:0050662coenzyme binding IEA--
         
    GLYR1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for GLYR1 

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: GLYR1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GLYR1
    8/75 QIAGEN miScript miRNA Assays for microRNAs that regulate GLYR1 (see all 75):
    hsa-miR-124* hsa-miR-26a-2* hsa-miR-607 hsa-miR-605 hsa-miR-578 hsa-miR-4267 hsa-miR-629* hsa-miR-208b
    SwitchGear 3'UTR luciferase reporter plasmidGLYR1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GLYR1 (see all 4)
    OriGene shRNA RFP: GLYR1
    OriGene siRNA: GLYR1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GLYR1
    Sirion Biotech Custom design and validation of potent shRNA sequences against GLYR1 

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GLYR1
    Sirion Biotech Customized adenovirus for overexpression of GLYR1 
    Sirion Biotech Customized adenovirus for potent knockdown of GLYR1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GLYR1 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GLYR1 (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: GLYR1 (NM_032569)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GLYR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GLYR1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GLYR1
    Search LifeMap BioReagents cell lines for GLYR1
    Sirion Biotech Customized stable knockdown cell line services for GLYR1 
    Sirion Biotech Customized inducible knockdown cell line services for GLYR1
    Sirion Biotech Customized stable overexpressing cell line services for GLYR1
    Sirion Biotech Customized inducible overexpressing cell line services for GLYR1

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GLYR1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GLYR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/9 Interacting proteins for GLYR1 (Q49A262, 3 ENSP000003227164) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AICDAQ9GZX73, ENSP000002293354I2D: score=1 STRING: ENSP00000229335
    ESR1P033723, ENSP000002062494I2D: score=1 STRING: ENSP00000206249
    UBE2E2Q96LR53I2D: score=5 
    UBCENSP000003448184STRING: ENSP00000344818
    SUMO2ENSP000004059654STRING: ENSP00000405965
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006098pentose-phosphate shunt IEA--

    GLYR1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GLYR1
    Search CenterWatch for drugs/clinical trials and news about GLYR1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GLYR1 gene: 
    NM_032569.3  

    Unigene Cluster for GLYR1:

    Glyoxylate reductase 1 homolog (Arabidopsis)
    Hs.387255  [show with all ESTs]
    Unigene Representative Sequence: NM_032569
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000589389 ENST00000588732 ENST00000436648 ENST00000321919(uc002cxx.4 uc002cxy.3 uc002cya.2 uc010uxv.1)
    ENST00000587936 ENST00000591451 ENST00000591846 ENST00000588297 ENST00000586095
    ENST00000587297 ENST00000586901 ENST00000587875 ENST00000591159 ENST00000381983(uc002cxz.1)


    miRNA
    Products:
         
    OriGene 3'-UTR Clone: GLYR1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GLYR1
    8/75 QIAGEN miScript miRNA Assays for microRNAs that regulate GLYR1 (see all 75):
    hsa-miR-124* hsa-miR-26a-2* hsa-miR-607 hsa-miR-605 hsa-miR-578 hsa-miR-4267 hsa-miR-629* hsa-miR-208b
    SwitchGear 3'UTR luciferase reporter plasmidGLYR1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GLYR1 (see all 4)
    OriGene shRNA RFP: GLYR1
    OriGene siRNA: GLYR1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GLYR1
    Sirion Biotech Custom design and validation of potent shRNA sequences against GLYR1 
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GLYR1 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GLYR1 (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: GLYR1 (NM_032569)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GLYR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GLYR1 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GLYR1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GLYR1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GLYR1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GLYR1

    Additional cDNA sequence: 

    AF217521.1 AF244907.1 AF326966.1 AK096730.1 AK296842.1 AK307834.1 AY352585.1 BC003693.1 
    BC022809.1 BC032855.1 BC047223.1 BC048291.1 BC063039.1 BC064940.1 BC073868.1 CR933687.1 

    18 DOTS entries:

    DT.97820255  DT.455865  DT.120704602  DT.40107533  DT.97854573  DT.97854571  DT.99936178  DT.95335108 
    DT.92424029  DT.97781123  DT.91741097  DT.91875664  DT.91884444  DT.92424028  DT.95202224  DT.97764065 
    DT.100798583  DT.91881931 

    24/521 AceView cDNA sequences (see all 521):

    BM503391 BM728680 AK098348 BX331741 CF135011 AI679628 AI186368 CF127496 
    BU158924 CB529066 BM931710 CR623197 BM454630 AA341472 CF456973 BQ219706 
    BQ068325 AI401496 AI336225 BQ424215 BG013932 BE503523 AA480226 AA887264 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for GLYR1 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19
    SP1:              -     -     -                 -                                                                                                               
    SP2:              -     -     -                 -                                                     -                                                         
    SP3:              -     -     -                 -                                   -                                                                           
    SP4:                                            -                                                                                                               
    SP5:              -           -                 -                                                                                                               


    ECgene alternative splicing isoforms for GLYR1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GLYR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATTTTGTGCA
    GLYR1 Expression
    About this image
    See GLYR1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GLYR1

    SOURCE GeneReport for Unigene cluster: Hs.387255
        SABiosciences Custom PCR Arrays for GLYR1

    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GLYR1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GLYR1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GLYR1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GLYR1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GLYR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for GLYR1 gene from 9/29 species (see all 29)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Glyr11 , 5 glyoxylate reductase 1 homolog (Arabidopsis)1, 5 92.87(n)1
    98.73(a)1
      16 (2.49 cM)5
    740221  NM_001079814.11  NP_001073282.11 
     50139065 
    chicken
    (Gallus gallus)
    Aves GLYR11 glyoxylate reductase 1 homolog (Arabidopsis) 83.06(n)
    94.39(a)
      426988  NM_001006572.1  NP_001006572.1 
    lizard
    (Anolis carolinensis)
    Reptilia GLYR16
    HIBADH6
    --
    93(a)
    23(a)
    1 ↔ 1
    possible ortholog
    GL343263.1(1308359-1324099)
    GL343275.1(1026118-1107736)
    zebrafish
    (Danio rerio)
    Actinopterygii glyr11 glyoxylate reductase 1 homolog (Arabidopsis) 74.27(n)
    86.93(a)
      493611  NM_001007771.1  NP_001007772.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG47471 CG4747 46.85(n)
    34.95(a)
      192507  NM_001201838.1  NP_001188767.1 
    worm
    (Caenorhabditis elegans)
    Secernentea B0250.56
    Probable 3-hydroxyisobutyrate dehydrogenase, mitoc...
    23(a)
    possible ortholog
    V(20493893-20497315)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons GLYR11 glyoxylate reductase 1 52.25(n)
    49.65(a)
      822139  NM_113449.3  NP_566768.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g05627001 hypothetical protein 55.83(n)
    52.14(a)
      4329690  NM_001053689.1  NP_001047154.1 
    E. coli
    (Escherichia coli)
    Gamma proteobacteria garR6
    glxR6
    (see all 4)
    tartronate semialdehyde reductase, NADH-dependent
    (see all 4)
    28(a)
    26(a)
    (see all 4)
    possible ortholog
    possible ortholog
    (see all 4)
    Chromosome(3269889-3270773)
    Chromosome(535810-536688)


    ENSEMBL Gene Tree for GLYR1 (if available)
    TreeFam Gene Tree for GLYR1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GLYR1 gene
    HIBADH2  
    1 SIMAP similar gene for GLYR1 using alignment to 6 protein entries:     GLYR1_HUMAN (see all proteins):
    N-PAC

    GLYR1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for GLYR1
    PGOHUM00000247669


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/947 NCBI SNPs in GLYR1 are shown (see all 947    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1175810211,2
    F--4855048(+) CACTTG/CTCCCC 1 -- ut311Minor allele frequency- C:0.02NA 120
    rs1913828601,2
    --4855077(+) GAAGGA/GTGCTG 1 -- ut310--------
    rs1846348261,2
    --4855136(+) GGAGAC/TAGGTG 1 -- ut310--------
    rs2003564751,2
    --4855230(+) GGTGTC/TGACAG 1 -- ut310--------
    rs1381963151,2
    C--4855258(+) CGGTAC/GACGGC 2 V syn10--------
    rs80640241,2
    C,F,A,H--4855279(+) TTGTCG/AGACTG 2 /S syn138Minor allele frequency- A:0.43MN NA NS EA WA CSA EU 9368
    rs177031111,2
    C,H--4855307(+) TTTTGT/CACACC 2 /Y /C mis1 ese38Minor allele frequency- C:0.00NA NS EA 544
    rs794518381,2
    F--4855435(+) GGTTAG/CGAATC 1 -- int11Minor allele frequency- C:0.02WA 118
    rs1148843191,2
    F--4855461(+) ATGAAG/TCACCT 1 -- int11Minor allele frequency- T:0.03WA 118
    rs785494001,2
    F--4855500(+) TTCTTG/ACTCTG 1 -- int11Minor allele frequency- A:0.04WA 118

    HapMap Linkage Disequilibrium report for GLYR1 (4853204 - 4897343 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for GLYR1
         3 CNVs: 72442 5436 72441

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GLYR1
    DNA2.0 Custom Variant and Variant Library Synthesis for GLYR1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    GLYR1 for disorders           About GeneDecksing

    OMIM gene information: 610660    OMIM disorders: --

    7 diseases for GLYR1:    About MalaCards
    band keratopathy    listeriosis    nasopharynx carcinoma    keratopathy
    tuberculosis    carcinoma    mycobacterium tuberculosis

    1 disease from the University of Copenhagen DISEASES database for GLYR1:
    Band keratopathy

    Export disorders for GLYR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GLYR1 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with GLYR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Nuclear protein NP60 regulates p38 MAPK activity. (PubMed id 16352664)1, 2, 3 Fu J.... Gu J. (2006)
    2. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    3. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    4. Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    6. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    7. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    8. Identification of proteins associated with ligand-acti vated estrogen receptor a in human breast cancer cell nuclei by tandem affinity purification and nano LC-MS/MS. (PubMed id 21182205)1 Tarallo R....Weisz A. (2011)
    9. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    10. Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84656 HGNC: 24434 AceView: FLJ22386andN-PAC Ensembl:ENSG00000140632 euGenes: HUgn84656
    ECgene: GLYR1 H-InvDB: GLYR1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GLYR1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GLYR1 gene:
    Search GeneIP for patents involving GLYR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for GLYR1  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GLYR1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GLYR1  
     OriGene Protein Over-expression Lysate for GLYR1   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for GLYR1   OriGene 3'-UTR Clone for GLYR1  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GLYR1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GLYR1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for GLYR1   OriGene Custom Protein Services for GLYR1  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GLYR1
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GLYR1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GLYR1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GLYR1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GLYR1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GLYR1
     GenScript Custom Purified and Recombinant Proteins Services for GLYR1 GenScript cDNA clones with any tag delivered in your preferred vector for GLYR1
     GenScript Custom Assay Services for GLYR1 GenScript Custom Superior Antibodies Services for GLYR1
     GenScript Custom overexpressing Cell Line Services for GLYR1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Search Regulatory tfbs for GLYR1
     Search Chromatin IP Primers for GLYR1
     RT2 qPCR Primer Assay in human, mouse, rat GLYR1
     Search GNC Networks for GLYR1
     SABiosciences Custom PCR Arrays for GLYR1
     Search Tocris compounds for GLYR1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     GLYR1 antibodies
     GLYR1 proteins
     GLYR1 lysates
     Search for Antibodies for GLYR1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for GLYR1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     GLYR1 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for GLYR1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GLYR1
     SwitchGear 3'UTR luciferase reporter plasmids for GLYR1
     SwitchGear Promoter luciferase reporter plasmids for GLYR1
     Search ThermoFisher Antibodies for GLYR1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GLYR1
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for GLYR1
    Sirion Biotech Customized:
     stable knockdown cell line services for GLYR1
     inducible knockdown cell line services for GLYR1
     design and validation of potent shRNA sequences against GLYR1
     adenovirus for potent knockdown of GLYR1
     adenovirus for overexpression of GLYR1
     stable overexpressing cell line services for GLYR1
     inducible overexpressing cell line services for GLYR1
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      GLYR1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4