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Aliases for GLYCTK Gene

Aliases for GLYCTK Gene

  • Glycerate Kinase 2 3
  • EC 4 63
  • HBEBP4 3 4
  • HBeAg Binding Protein 4 3
  • HBeAg-Binding Protein 2 3
  • HBeAg-Binding Protein 4 4
  • HBeAgBP4A 3
  • HBEBP2 3

External Ids for GLYCTK Gene

Previous GeneCards Identifiers for GLYCTK Gene

  • GC03P052177
  • GC03P052280
  • GC03P052296

Summaries for GLYCTK Gene

Entrez Gene Summary for GLYCTK Gene

  • This locus encodes a member of the glycerate kinase type-2 family. The encoded enzyme catalyzes the phosphorylation of (R)-glycerate and may be involved in serine degradation and fructose metabolism. Decreased activity of the encoded enzyme may be associated with the disease D-glyceric aciduria. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009]

GeneCards Summary for GLYCTK Gene

GLYCTK (Glycerate Kinase) is a Protein Coding gene. Diseases associated with GLYCTK include d-glyceric aciduria. Among its related pathways are Carbon metabolism and Metabolism. GO annotations related to this gene include glycerate kinase activity.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLYCTK Gene

Genomics for GLYCTK Gene

Regulatory Elements for GLYCTK Gene

Genomic Location for GLYCTK Gene

52,287,089 bp from pter
52,295,256 bp from pter
8,168 bases
Plus strand

Genomic View for GLYCTK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GLYCTK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLYCTK Gene

Proteins for GLYCTK Gene

  • Protein details for GLYCTK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Glycerate kinase
    Protein Accession:
    Secondary Accessions:
    • Q0P630
    • Q2EZ43
    • Q6Y2K6
    • Q7Z6G5
    • Q86YR8
    • Q8TED2
    • Q8WTY2

    Protein attributes for GLYCTK Gene

    523 amino acids
    Molecular mass:
    55253 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH36862.1; Type=Frameshift; Positions=177; Evidence={ECO:0000305};

    Alternative splice isoforms for GLYCTK Gene

neXtProt entry for GLYCTK Gene

Proteomics data for GLYCTK Gene at MOPED

Post-translational modifications for GLYCTK Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

Domains & Families for GLYCTK Gene

Protein Domains for GLYCTK Gene


Suggested Antigen Peptide Sequences for GLYCTK Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycerate kinase type-2 family.
  • Belongs to the glycerate kinase type-2 family.
genes like me logo Genes that share domains with GLYCTK: view

No data available for Gene Families for GLYCTK Gene

Function for GLYCTK Gene

Molecular function for GLYCTK Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.1 mM for D-glycerate {ECO:0000269 PubMed:20949620};
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + D-glycerate = ADP + 3-phospho-D-glycerate

Enzyme Numbers (IUBMB) for GLYCTK Gene

Gene Ontology (GO) - Molecular Function for GLYCTK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0005524 ATP binding IEA --
GO:0008887 glycerate kinase activity IDA 16753811
genes like me logo Genes that share ontologies with GLYCTK: view
genes like me logo Genes that share phenotypes with GLYCTK: view

Animal Model Products

CRISPR Products

miRNA for GLYCTK Gene

miRTarBase miRNAs that target GLYCTK

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GLYCTK

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for GLYCTK Gene

Localization for GLYCTK Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLYCTK Gene

Isoform 1: Cytoplasm.
Isoform 2: Cytoplasm. Mitochondrion.

Subcellular locations from

Jensen Localization Image for GLYCTK Gene COMPARTMENTS Subcellular localization image for GLYCTK gene
Compartment Confidence
mitochondrion 5
chloroplast 2

Gene Ontology (GO) - Cellular Components for GLYCTK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 16753811
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with GLYCTK: view

Pathways & Interactions for GLYCTK Gene

genes like me logo Genes that share pathways with GLYCTK: view

Gene Ontology (GO) - Biological Process for GLYCTK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA 16753811
genes like me logo Genes that share ontologies with GLYCTK: view

No data available for SIGNOR curated interactions for GLYCTK Gene

Drugs & Compounds for GLYCTK Gene

(2) Drugs for GLYCTK Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
3-Phosphoglyceric acid Experimental Pharma 0

(2) Additional Compounds for GLYCTK Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
Glyceric acid
  • (R)-glycerate
  • a,b-Hydroxypropionate
  • a,b-Hydroxypropionic acid
  • D-Glycerate
  • D-Glyceric acid
genes like me logo Genes that share compounds with GLYCTK: view

Transcripts for GLYCTK Gene

Unigene Clusters for GLYCTK Gene

Glycerate kinase:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GLYCTK

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GLYCTK Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8
SP1: - -
SP2: - - - - - - -
SP3: - -
SP4: - - - - - - - -
SP5: - - - - - - - -
SP6: - - - -
SP7: - -
SP8: - - - -
SP9: - - -
SP10: - -

Relevant External Links for GLYCTK Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GLYCTK Gene

mRNA expression in normal human tissues for GLYCTK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GLYCTK Gene

This gene is overexpressed in Liver (x22.8).

Protein differential expression in normal tissues from HIPED for GLYCTK Gene

This gene is overexpressed in Gallbladder (46.4) and Liver (20.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GLYCTK Gene

SOURCE GeneReport for Unigene cluster for GLYCTK Gene Hs.415312

mRNA Expression by UniProt/SwissProt for GLYCTK Gene

Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with GLYCTK: view

Protein tissue co-expression partners for GLYCTK Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

Orthologs for GLYCTK Gene

This gene was present in the common ancestor of animals.

Orthologs for GLYCTK Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GLYCTK 35
  • 85.66 (n)
  • 86.42 (a)
  • 87 (a)
(Canis familiaris)
Mammalia GLYCTK 35
  • 86.36 (n)
  • 87.76 (a)
-- 36
  • 80 (a)
cfa-mir-135a-1 36
  • 82 (a)
(Mus musculus)
Mammalia Glyctk 35
  • 82.66 (n)
  • 84.32 (a)
Glyctk 16
Glyctk 36
  • 84 (a)
(Pan troglodytes)
Mammalia GLYCTK 35
  • 99.68 (n)
  • 99.62 (a)
ptr-mir-135a-1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Glyctk 35
  • 82.6 (n)
  • 83.56 (a)
(Monodelphis domestica)
Mammalia GLYCTK 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia GLYCTK 36
  • 70 (a)
(Gallus gallus)
Aves GLYCTK 35
  • 64.9 (n)
  • 64.29 (a)
  • 62 (a)
(Anolis carolinensis)
Reptilia GLYCTK 36
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia glyctk 35
  • 58.96 (n)
  • 55.78 (a)
(Danio rerio)
Actinopterygii Dr.13856 35
glyctk 35
  • 57.43 (n)
  • 55.21 (a)
glyctk 36
  • 50 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007988 35
  • 54.19 (n)
  • 46.78 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9886 35
  • 47.32 (n)
  • 41.33 (a)
CG9886 36
  • 39 (a)
(Caenorhabditis elegans)
Secernentea C13B9.2 35
  • 45.7 (n)
  • 39.82 (a)
C13B9.2 36
  • 36 (a)
Species with no ortholog for GLYCTK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GLYCTK Gene

Gene Tree for GLYCTK (if available)
Gene Tree for GLYCTK (if available)

Paralogs for GLYCTK Gene

No data available for Paralogs for GLYCTK Gene

Variants for GLYCTK Gene

Sequence variations from dbSNP and Humsavar for GLYCTK Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs2276834 -- 52,291,743(-) ACCTC(C/T)CAAGA intron-variant, splice-acceptor-variant
rs2293159 -- 52,293,292(+) CTATA(C/T)CTATT downstream-variant-500B, utr-variant-3-prime, nc-transcript-variant, intron-variant
rs9813489 - 52,292,735(+) GGAGA(C/T)CATGG utr-variant-3-prime, reference, missense, nc-transcript-variant, intron-variant
rs34908853 -- 52,292,397(+) CTGCC(A/G)CGTTC reference, missense, synonymous-codon, nc-transcript-variant, intron-variant
rs35335735 -- 52,291,748(+) AGAGG(G/T)GGGGG intron-variant, synonymous-codon, reference, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for GLYCTK Gene

Variant ID Type Subtype PubMed ID
nsv519445 CNV Gain+Loss 19592680
nsv470572 CNV Loss 18288195
nsv834694 CNV Gain 17160897
nsv834695 CNV Loss 17160897
dgv5136n71 CNV Gain 21882294
nsv876789 CNV Loss 21882294
nsv834696 CNV Loss 17160897

Variation tolerance for GLYCTK Gene

Residual Variation Intolerance Score: 56.13% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.75; 57.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GLYCTK Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLYCTK Gene

Disorders for GLYCTK Gene

MalaCards: The human disease database

(1) MalaCards diseases for GLYCTK Gene - From: OMIM, ClinVar, Orphanet, Swiss-Prot, and GeneCards

Disorder Aliases PubMed IDs
d-glyceric aciduria
  • d-glycericacidemia
- elite association


  • D-glyceric aciduria (D-GA) [MIM:220120]: A rare metabolic disease characterized by chronic metabolic acidosis and a highly variable clinical phenotype. Clinical features range from an encephalopathic presentation with seizures, microcephaly, severe mental retardation and early death, to milder manifestations with only speech delay or even normal development. {ECO:0000269 PubMed:20949620}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for GLYCTK

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GLYCTK: view

No data available for Genatlas for GLYCTK Gene

Publications for GLYCTK Gene

  1. Isolation and characterization of the human D-glyceric acidemia related glycerate kinase gene GLYCTK1 and its alternatively splicing variant GLYCTK2. (PMID: 16753811) Guo J.-H. … Yu L. (DNA Seq. 2006) 2 23 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  3. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67
  4. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. (PMID: 23974872) Ripke S. … Sullivan P.F. (Nat. Genet. 2013) 67
  5. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. (PMID: 21926972) (Nat. Genet. 2011) 67

Products for GLYCTK Gene

Sources for GLYCTK Gene

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