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Aliases for GLYATL3 Gene

Aliases for GLYATL3 Gene

  • Glycine-N-Acyltransferase Like 3 2 3 5
  • C6orf140 3 4
  • Glycine N-Acyltransferase-Like Protein 3 3
  • Chromosome 6 Open Reading Frame 140 2
  • Glycine-N-Acyltransferase-Like 3 2
  • EC 2.3.1.- 4
  • BA28H17.2 3

External Ids for GLYATL3 Gene

Previous HGNC Symbols for GLYATL3 Gene

  • C6orf140

Previous GeneCards Identifiers for GLYATL3 Gene

  • GC06U901652
  • GC06P049197

Summaries for GLYATL3 Gene

GeneCards Summary for GLYATL3 Gene

GLYATL3 (Glycine-N-Acyltransferase Like 3) is a Protein Coding gene. Among its related pathways are Metabolism and Cytochrome P450 - arranged by substrate type. GO annotations related to this gene include transferase activity, transferring acyl groups other than amino-acyl groups and glycine N-acyltransferase activity. An important paralog of this gene is GLYAT.

UniProtKB/Swiss-Prot for GLYATL3 Gene

  • Acyltransferase which transfers the acyl group to the N-terminus of glycine.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLYATL3 Gene

Genomics for GLYATL3 Gene

Regulatory Elements for GLYATL3 Gene

Enhancers for GLYATL3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F049523 1 ENCODE 11.9 +23.7 23681 1.3 ATF1 MLX ZFP64 ARID4B DMAP1 ZNF48 YY1 SLC30A9 MXD4 MIER2 MUT GLYATL3 LOC101927020 LOC101927048 CENPQ GC06P049517 GC06M049537
GH06F049532 1.2 Ensembl ENCODE 11.9 +32.5 32456 0.8 YBX3 ELF3 TBP ZBTB40 ZNF2 RAD21 RFX5 CHAMP1 SCRT2 ZNF143 GLYATL3 CENPQ GC06M049537 GC06P049517
GH06F049479 0.5 ENCODE 10.9 -20.1 -20147 0.8 ZNF547 GLYATL3 CENPQ
GH06F049908 0.5 ENCODE 10.6 +409.5 409536 1.7 ZNF316 SMARCA4 MAFK GLYATL3 MUT GC06P049919 CRISP1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around GLYATL3 on UCSC Golden Path with GeneCards custom track

Genomic Location for GLYATL3 Gene

49,499,958 bp from pter
49,528,064 bp from pter
28,107 bases
Plus strand

Genomic View for GLYATL3 Gene

Genes around GLYATL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GLYATL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GLYATL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLYATL3 Gene

Proteins for GLYATL3 Gene

  • Protein details for GLYATL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Glycine N-acyltransferase-like protein 3
    Protein Accession:

    Protein attributes for GLYATL3 Gene

    288 amino acids
    Molecular mass:
    32704 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAI13086.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for GLYATL3 Gene

Post-translational modifications for GLYATL3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GLYATL3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GLYATL3 Gene

Domains & Families for GLYATL3 Gene

Suggested Antigen Peptide Sequences for GLYATL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycine N-acyltransferase family.
  • Belongs to the glycine N-acyltransferase family.
genes like me logo Genes that share domains with GLYATL3: view

No data available for Gene Families for GLYATL3 Gene

Function for GLYATL3 Gene

Molecular function for GLYATL3 Gene

UniProtKB/Swiss-Prot Function:
Acyltransferase which transfers the acyl group to the N-terminus of glycine.

Enzyme Numbers (IUBMB) for GLYATL3 Gene

Gene Ontology (GO) - Molecular Function for GLYATL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0047961 glycine N-acyltransferase activity IEA --
genes like me logo Genes that share ontologies with GLYATL3: view

Phenotypes for GLYATL3 Gene

GenomeRNAi human phenotypes for GLYATL3:
genes like me logo Genes that share phenotypes with GLYATL3: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GLYATL3 Gene

Localization for GLYATL3 Gene

Subcellular locations from

Jensen Localization Image for GLYATL3 Gene COMPARTMENTS Subcellular localization image for GLYATL3 gene
Compartment Confidence
mitochondrion 3
cytosol 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GLYATL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with GLYATL3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GLYATL3 Gene

Pathways & Interactions for GLYATL3 Gene

genes like me logo Genes that share pathways with GLYATL3: view

Interacting Proteins for GLYATL3 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000360240 Q5SZD4-GLYL3_HUMAN for GLYATL3 Gene via STRING IID

Gene Ontology (GO) - Biological Process for GLYATL3 Gene


No data available for SIGNOR curated interactions for GLYATL3 Gene

Drugs & Compounds for GLYATL3 Gene

(4) Drugs for GLYATL3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aminohippuric acid Approved Pharma 0
3-Hydroxyhippuric acid Experimental Pharma 0
Glycochenodeoxycholic Acid Experimental Pharma 0
Glycocholic acid Pharma 1

(32) Additional Compounds for GLYATL3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 2-Furoylglycine
  • Furfuroylglycine
  • Furoylglycine
  • N-(2-Furanylcarbonyl)glycine
  • N-(2-Furoyl)glycine
  • (2-methyl-butyrylamino)-acetate
  • (2-methyl-butyrylamino)-acetic acid
  • 2-MBG
  • 2-methylbutyryl glycine
  • 2-Methylbutyrylglycine
  • 3alpha,7beta,12alpha-Trihydroxyoxocholanyl-Glycine
  • Glycocholic acid
  • N-Cholylglycine
  • 3-Methylcrotonyl glycine
  • 3-Methylcrotonyl-glycine
  • 3-Methylcrotonylglycin
  • 3-Methylcrotonylglycine
  • beta-Methylcrotonylglycine
genes like me logo Genes that share compounds with GLYATL3: view

Transcripts for GLYATL3 Gene

mRNA/cDNA for GLYATL3 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GLYATL3 Gene

Glycine-N-acyltransferase-like 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GLYATL3 Gene

No ASD Table

Relevant External Links for GLYATL3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GLYATL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GLYATL3 Gene

Protein differential expression in normal tissues from HIPED for GLYATL3 Gene

This gene is overexpressed in Uterus (47.8), Liver (11.7), and Rectum (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GLYATL3 Gene

NURSA nuclear receptor signaling pathways regulating expression of GLYATL3 Gene:


SOURCE GeneReport for Unigene cluster for GLYATL3 Gene:

genes like me logo Genes that share expression patterns with GLYATL3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for GLYATL3 Gene

Orthologs for GLYATL3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GLYATL3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GLYATL3 34 35
  • 99.07 (n)
(Canis familiaris)
Mammalia GLYATL3 34 35
  • 89.08 (n)
(Mus musculus)
Mammalia Glyatl3 34 16 35
  • 85.76 (n)
(Rattus norvegicus)
Mammalia Glyatl3 34
  • 85.25 (n)
(Bos Taurus)
Mammalia GLYATL3 34 35
  • 84.03 (n)
(Monodelphis domestica)
Mammalia GLYATL3 35
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia oan-mir-7407-1 35
  • 65 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 44 (a)
-- 35
  • 38 (a)
-- 35
  • 37 (a)
-- 35
  • 36 (a)
-- 35
  • 36 (a)
-- 35
  • 36 (a)
-- 35
  • 35 (a)
(Danio rerio)
Actinopterygii si:dkey-76k16.5 35
  • 30 (a)
Species where no ortholog for GLYATL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GLYATL3 Gene

Gene Tree for GLYATL3 (if available)
Gene Tree for GLYATL3 (if available)

Paralogs for GLYATL3 Gene

Paralogs for GLYATL3 Gene

(4) SIMAP similar genes for GLYATL3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GLYATL3: view

Variants for GLYATL3 Gene

Sequence variations from dbSNP and Humsavar for GLYATL3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs10223330 -- 49,525,662(+) gttca(A/G)agtta intron-variant
rs10223447 -- 49,519,504(+) AGTCA(C/T)TGGTA intron-variant
rs10428801 -- 49,499,149(+) CAAGA(C/T)CAAAA upstream-variant-2KB
rs10630585 -- 49,525,109(+) TTTTT(-/T/TTT)ATTGA intron-variant
rs10685826 -- 49,519,278(+) TAGTT(-/GTGA)GTAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GLYATL3 Gene

Variant ID Type Subtype PubMed ID
dgv5960n100 CNV gain 25217958
nsv1019611 CNV gain 25217958

Variation tolerance for GLYATL3 Gene

Gene Damage Index Score: 20.87; 99.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GLYATL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLYATL3 Gene

Disorders for GLYATL3 Gene

Relevant External Links for GLYATL3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GLYATL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GLYATL3 Gene

Publications for GLYATL3 Gene

  1. Identification of glycine N-acyltransferase-like 2 (GLYATL2) as a transferase that produces N-acyl glycines in humans. (PMID: 20305126) Waluk D.P. … Hunt M.C. (FASEB J. 2010) 2 3 64
  2. Voxelwise genome-wide association study (vGWAS). (PMID: 20171287) Stein J.L. … Thompson P. (Neuroimage 2010) 3 46 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. An integrated workflow for charting the human interaction proteome: insights into the PP2A system. (PMID: 19156129) Glatter T. … Gstaiger M. (Mol. Syst. Biol. 2009) 3 64

Products for GLYATL3 Gene

Sources for GLYATL3 Gene

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