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Aliases for GLYATL2 Gene

Aliases for GLYATL2 Gene

  • Glycine-N-Acyltransferase Like 2 2 3 5
  • Acyl-CoA:Glycine N-Acyltransferase-Like Protein 2 3 4
  • Glycine-N-Acyltransferase-Like 2 2 3
  • Glycine Acyltransferase Family-B 3
  • EC 2.3.1.13 4
  • BXMAS2-10 3
  • GATF-B 3

External Ids for GLYATL2 Gene

Previous GeneCards Identifiers for GLYATL2 Gene

  • GC11M058359
  • GC11M058601
  • GC11M054947

Summaries for GLYATL2 Gene

GeneCards Summary for GLYATL2 Gene

GLYATL2 (Glycine-N-Acyltransferase Like 2) is a Protein Coding gene. Among its related pathways are Metabolism and Phase II conjugation. GO annotations related to this gene include transferase activity, transferring acyl groups other than amino-acyl groups and glycine N-acyltransferase activity. An important paralog of this gene is GLYATL3.

UniProtKB/Swiss-Prot for GLYATL2 Gene

  • Mitochondrial acyltransferase which transfers the acyl group to the N-terminus of glycine. Conjugates numerous substrates, such as arachidonoyl-CoA and saturated medium and long-chain acyl-CoAs ranging from chain-length C8:0-CoA to C18:0-CoA, to form a variety of N-acylglycines. Shows a preference for monounsaturated fatty acid oleoyl-CoA (C18:1-CoA) as an acyl donor. Does not exhibit any activity toward C22:6-CoA and chenodeoxycholoyl-CoA, nor toward serine or alanine.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLYATL2 Gene

Genomics for GLYATL2 Gene

Regulatory Elements for GLYATL2 Gene

Promoters for GLYATL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GLYATL2 on UCSC Golden Path with GeneCards custom track

Genomic Location for GLYATL2 Gene

Chromosome:
11
Start:
58,834,065 bp from pter
End:
58,904,215 bp from pter
Size:
70,151 bases
Orientation:
Minus strand

Genomic View for GLYATL2 Gene

Genes around GLYATL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GLYATL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GLYATL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLYATL2 Gene

Proteins for GLYATL2 Gene

  • Protein details for GLYATL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WU03-GLYL2_HUMAN
    Recommended name:
    Glycine N-acyltransferase-like protein 2
    Protein Accession:
    Q8WU03
    Secondary Accessions:
    • A5LGC7
    • Q86WC3
    • Q96AT2

    Protein attributes for GLYATL2 Gene

    Size:
    294 amino acids
    Molecular mass:
    34277 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GLYATL2 Gene

Proteomics data for GLYATL2 Gene at MOPED

Post-translational modifications for GLYATL2 Gene

  • Acetylation at Lys-19 drastically decreases the production of N-oleoyl and N-arachidonoyl glycines.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GLYATL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for GLYATL2

No data available for DME Specific Peptides for GLYATL2 Gene

Domains & Families for GLYATL2 Gene

Suggested Antigen Peptide Sequences for GLYATL2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WU03

UniProtKB/Swiss-Prot:

GLYL2_HUMAN :
  • Belongs to the glycine N-acyltransferase family.
Family:
  • Belongs to the glycine N-acyltransferase family.
genes like me logo Genes that share domains with GLYATL2: view

No data available for Gene Families for GLYATL2 Gene

Function for GLYATL2 Gene

Molecular function for GLYATL2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=4.4 uM for oleoyl-CoA {ECO:0000269 PubMed:20305126}; Vmax=933 nmol/min/mg enzyme with oleoyl-CoA as substrate {ECO:0000269 PubMed:20305126};
UniProtKB/Swiss-Prot CatalyticActivity:
Acyl-CoA + glycine = CoA + N-acylglycine.
UniProtKB/Swiss-Prot Function:
Mitochondrial acyltransferase which transfers the acyl group to the N-terminus of glycine. Conjugates numerous substrates, such as arachidonoyl-CoA and saturated medium and long-chain acyl-CoAs ranging from chain-length C8:0-CoA to C18:0-CoA, to form a variety of N-acylglycines. Shows a preference for monounsaturated fatty acid oleoyl-CoA (C18:1-CoA) as an acyl donor. Does not exhibit any activity toward C22:6-CoA and chenodeoxycholoyl-CoA, nor toward serine or alanine.

Enzyme Numbers (IUBMB) for GLYATL2 Gene

genes like me logo Genes that share phenotypes with GLYATL2: view

Animal Model Products

CRISPR Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GLYATL2 Gene

Localization for GLYATL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLYATL2 Gene

Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GLYATL2 Gene COMPARTMENTS Subcellular localization image for GLYATL2 gene
Compartment Confidence
endoplasmic reticulum 3
cytosol 2
mitochondrion 2
nucleus 2
plasma membrane 2
extracellular 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for GLYATL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with GLYATL2: view

Pathways & Interactions for GLYATL2 Gene

genes like me logo Genes that share pathways with GLYATL2: view

Pathways by source for GLYATL2 Gene

Interacting Proteins for GLYATL2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000287275%0d%0a9606.ENSP00000265140%0d%0a9606.ENSP00000260810%0d%0a
Selected Interacting proteins: ENSP00000287275 for GLYATL2 Gene via STRING

Gene Ontology (GO) - Biological Process for GLYATL2 Gene

None

No data available for SIGNOR curated interactions for GLYATL2 Gene

Drugs & Compounds for GLYATL2 Gene

(13) Drugs for GLYATL2 Gene - From: HMDB and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glycine Approved Nutra Full agonist, Agonist, Target Endogenous potentiator, co-transmitter 94
Acetylcysteine Approved Pharma Antioxidant;mucolytic agent 293
Aminohippurate Approved Pharma 0
3-Hydroxyhippuric acid Experimental Pharma 0
Acetylglycine Experimental Pharma 0

(72) Additional Compounds for GLYATL2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with GLYATL2: view

Transcripts for GLYATL2 Gene

mRNA/cDNA for GLYATL2 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GLYATL2 Gene

Glycine-N-acyltransferase-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GLYATL2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1:
SP2: -

Relevant External Links for GLYATL2 Gene

GeneLoc Exon Structure for
GLYATL2
ECgene alternative splicing isoforms for
GLYATL2

Expression for GLYATL2 Gene

mRNA expression in normal human tissues for GLYATL2 Gene

mRNA differential expression in normal tissues according to GTEx for GLYATL2 Gene

This gene is overexpressed in Minor Salivary Gland (x35.4).

Protein differential expression in normal tissues from HIPED for GLYATL2 Gene

This gene is overexpressed in Skin (32.0) and Oral epithelium (29.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GLYATL2 Gene



SOURCE GeneReport for Unigene cluster for GLYATL2 Gene Hs.254271

mRNA Expression by UniProt/SwissProt for GLYATL2 Gene

Q8WU03-GLYL2_HUMAN
Tissue specificity: Expressed at highest levels in salivary gland and trachea. Also detected in thyroid gland, spinal cord, prostate, lung and fetal brain.
genes like me logo Genes that share expression patterns with GLYATL2: view

Protein tissue co-expression partners for GLYATL2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for GLYATL2 Gene

Orthologs for GLYATL2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GLYATL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GLYATL2 35
  • 99.77 (n)
  • 99.66 (a)
GLYATL2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GLYATL2 36
  • 61 (a)
OneToOne
GLYATL2 35
  • 78.95 (n)
  • 66.21 (a)
mouse
(Mus musculus)
Mammalia Keg1 36
  • 40 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia GLYATL2 36
  • 38 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii si:dkey-76k16.5 36
  • 24 (a)
ManyToMany
Species with no ortholog for GLYATL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GLYATL2 Gene

ENSEMBL:
Gene Tree for GLYATL2 (if available)
TreeFam:
Gene Tree for GLYATL2 (if available)

Paralogs for GLYATL2 Gene

Paralogs for GLYATL2 Gene

(4) SIMAP similar genes for GLYATL2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for GLYATL2 Gene

genes like me logo Genes that share paralogs with GLYATL2: view

Variants for GLYATL2 Gene

Sequence variations from dbSNP and Humsavar for GLYATL2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs17856514 - 58,837,340(+) GTCAG(A/G)AGCTT reference, missense
rs11229651 - 58,834,836(+) TCCTT(C/T)CCTGT reference, missense
rs17851433 - 58,834,812(+) ATCTA(A/T)GAACA reference, missense
rs1014068 -- 58,840,248(+) GTTAG(C/T)AACCT intron-variant
rs1943279 -- 58,842,583(+) tacca(A/G)gacag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GLYATL2 Gene

Variant ID Type Subtype PubMed ID
dgv71n21 CNV Loss 19592680

Variation tolerance for GLYATL2 Gene

Residual Variation Intolerance Score: 96.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.52; 43.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GLYATL2 Gene

HapMap Linkage Disequilibrium report
GLYATL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLYATL2 Gene

Disorders for GLYATL2 Gene

Relevant External Links for GLYATL2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GLYATL2

No disorders were found for GLYATL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GLYATL2 Gene

Publications for GLYATL2 Gene

  1. Identification of glycine N-acyltransferase-like 2 (GLYATL2) as a transferase that produces N-acyl glycines in humans. (PMID: 20305126) Waluk D.P. … Hunt M.C. (FASEB J. 2010) 2 3 4 67
  2. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25 26
  3. How many drug targets are there? (PMID: 17139284) Overington J.P. … Hopkins A.L. (Nat Rev Drug Discov 2006) 25 26
  4. Reversible lysine acetylation regulates activity of human glycine N-acyltransferase-like 2 (hGLYATL2): implications for production of glycine-conjugated signaling molecules. (PMID: 22408254) Waluk D.P. … Hunt M.C. (J. Biol. Chem. 2012) 3
  5. Designation of enzyme activity of glycine-N-acyltransferase family genes and depression of glycine-N-acyltransferase in human hepatocellular carcinoma. (PMID: 22475485) Matsuo M. … Kishimoto T. (Biochem. Biophys. Res. Commun. 2012) 3

Products for GLYATL2 Gene

Sources for GLYATL2 Gene

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