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Aliases for GLYATL2 Gene

Aliases for GLYATL2 Gene

  • Glycine-N-Acyltransferase Like 2 2 3 5
  • Acyl-CoA:Glycine N-Acyltransferase-Like Protein 2 3 4
  • Glycine N-Acyltransferase-Like Protein 2 3
  • Glycine-N-Acyltransferase-Like 2 2
  • Glycine Acyltransferase Family-B 3
  • EC 2.3.1.13 4
  • BXMAS2-10 3
  • GATF-B 3

External Ids for GLYATL2 Gene

Previous GeneCards Identifiers for GLYATL2 Gene

  • GC11M058359
  • GC11M058601
  • GC11M054947

Summaries for GLYATL2 Gene

GeneCards Summary for GLYATL2 Gene

GLYATL2 (Glycine-N-Acyltransferase Like 2) is a Protein Coding gene. Among its related pathways are Conjugation of carboxylic acids and Cytochrome P450 - arranged by substrate type. GO annotations related to this gene include transferase activity, transferring acyl groups other than amino-acyl groups and glycine N-acyltransferase activity. An important paralog of this gene is GLYATL1P3.

UniProtKB/Swiss-Prot for GLYATL2 Gene

  • Mitochondrial acyltransferase which transfers the acyl group to the N-terminus of glycine. Conjugates numerous substrates, such as arachidonoyl-CoA and saturated medium and long-chain acyl-CoAs ranging from chain-length C8:0-CoA to C18:0-CoA, to form a variety of N-acylglycines. Shows a preference for monounsaturated fatty acid oleoyl-CoA (C18:1-CoA) as an acyl donor. Does not exhibit any activity toward C22:6-CoA and chenodeoxycholoyl-CoA, nor toward serine or alanine.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLYATL2 Gene

Genomics for GLYATL2 Gene

Regulatory Elements for GLYATL2 Gene

Enhancers for GLYATL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G058770 1.5 Ensembl ENCODE dbSUPER 5.6 +131.7 131700 4.8 HDGF PKNOX1 ATF1 ARNT TCF12 ZNF766 GATA2 KLF13 CAVIN1 NCOA1 GLYATL2 LOC105369314 GC11M058796
GH11G058726 1.2 Ensembl ENCODE 6.3 +177.1 177125 1.5 HDAC1 PKNOX1 ATF1 CBX3 TBL1XR1 TCF12 ZNF766 ZBTB11 CEBPB ELF4 GLYATL2 GLYAT GC11P058692
GH11G058921 1 Ensembl ENCODE 6 -19.0 -19014 3.3 CTCF ZNF654 SP2 KLF17 MNT EP300 RAD21 FOXA1 JUND ZNF341 GLYATL1 GLYATL2 ENSG00000255523
GH11G058904 0.9 ENCODE 6.4 -1.4 -1401 1.6 HDAC1 PKNOX1 SIN3A ZNF76 ZNF2 ZEB1 ZNF121 ZNF366 ZNF350 KLF7 GLYATL1 GLYATL2 ENSG00000255523
GH11G058788 1 Ensembl ENCODE 5.7 +115.6 115590 1.0 CTCF IRF2 RB1 RAD21 CHAMP1 YY1 FOSL1 ZNF143 SMC3 NFE2 GLYAT GLYATL2 GC11M058796 LOC105369314
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GLYATL2 on UCSC Golden Path with GeneCards custom track

Promoters for GLYATL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000039988 -1485 601 PKNOX1 SIN3A ZNF76 ZNF2 ZEB1 ZNF366 ZNF350 FOS KLF7 ZNF680

Genomic Location for GLYATL2 Gene

Chromosome:
11
Start:
58,834,065 bp from pter
End:
58,904,215 bp from pter
Size:
70,151 bases
Orientation:
Minus strand

Genomic View for GLYATL2 Gene

Genes around GLYATL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GLYATL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GLYATL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLYATL2 Gene

Proteins for GLYATL2 Gene

  • Protein details for GLYATL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WU03-GLYL2_HUMAN
    Recommended name:
    Glycine N-acyltransferase-like protein 2
    Protein Accession:
    Q8WU03
    Secondary Accessions:
    • A5LGC7
    • Q86WC3
    • Q96AT2

    Protein attributes for GLYATL2 Gene

    Size:
    294 amino acids
    Molecular mass:
    34277 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GLYATL2 Gene

Post-translational modifications for GLYATL2 Gene

  • Acetylation at Lys-19 drastically decreases the production of N-oleoyl and N-arachidonoyl glycines.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GLYATL2 Gene

No data available for DME Specific Peptides for GLYATL2 Gene

Domains & Families for GLYATL2 Gene

Suggested Antigen Peptide Sequences for GLYATL2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WU03

UniProtKB/Swiss-Prot:

GLYL2_HUMAN :
  • Belongs to the glycine N-acyltransferase family.
Family:
  • Belongs to the glycine N-acyltransferase family.
genes like me logo Genes that share domains with GLYATL2: view

No data available for Gene Families for GLYATL2 Gene

Function for GLYATL2 Gene

Molecular function for GLYATL2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=4.4 uM for oleoyl-CoA {ECO:0000269 PubMed:20305126}; Vmax=933 nmol/min/mg enzyme with oleoyl-CoA as substrate {ECO:0000269 PubMed:20305126};
UniProtKB/Swiss-Prot CatalyticActivity:
Acyl-CoA + glycine = CoA + N-acylglycine.
UniProtKB/Swiss-Prot Function:
Mitochondrial acyltransferase which transfers the acyl group to the N-terminus of glycine. Conjugates numerous substrates, such as arachidonoyl-CoA and saturated medium and long-chain acyl-CoAs ranging from chain-length C8:0-CoA to C18:0-CoA, to form a variety of N-acylglycines. Shows a preference for monounsaturated fatty acid oleoyl-CoA (C18:1-CoA) as an acyl donor. Does not exhibit any activity toward C22:6-CoA and chenodeoxycholoyl-CoA, nor toward serine or alanine.

Enzyme Numbers (IUBMB) for GLYATL2 Gene

Gene Ontology (GO) - Molecular Function for GLYATL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0047961 glycine N-acyltransferase activity IEA --
genes like me logo Genes that share ontologies with GLYATL2: view
genes like me logo Genes that share phenotypes with GLYATL2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GLYATL2 Gene

Localization for GLYATL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLYATL2 Gene

Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GLYATL2 gene
Compartment Confidence
endoplasmic reticulum 3
plasma membrane 2
mitochondrion 2
nucleus 2
cytosol 2
extracellular 1
lysosome 1

Gene Ontology (GO) - Cellular Components for GLYATL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005783 endoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with GLYATL2: view

Pathways & Interactions for GLYATL2 Gene

genes like me logo Genes that share pathways with GLYATL2: view

Interacting Proteins for GLYATL2 Gene

Gene Ontology (GO) - Biological Process for GLYATL2 Gene

None

No data available for SIGNOR curated interactions for GLYATL2 Gene

Drugs & Compounds for GLYATL2 Gene

(11) Drugs for GLYATL2 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glycine Approved, Vet_approved Nutra Full agonist, Agonist, Target 232
Acetylcysteine Approved, Investigational Pharma Antioxidant;mucolytic agent 330
Aminohippuric acid Approved Pharma 0
3-Hydroxyhippuric acid Experimental Pharma 0
Glycochenodeoxycholic Acid Experimental Pharma 0

(74) Additional Compounds for GLYATL2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with GLYATL2: view

Transcripts for GLYATL2 Gene

mRNA/cDNA for GLYATL2 Gene

(4) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GLYATL2 Gene

Glycine-N-acyltransferase-like 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GLYATL2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1:
SP2: -

Relevant External Links for GLYATL2 Gene

GeneLoc Exon Structure for
GLYATL2
ECgene alternative splicing isoforms for
GLYATL2

Expression for GLYATL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GLYATL2 Gene

mRNA differential expression in normal tissues according to GTEx for GLYATL2 Gene

This gene is overexpressed in Minor Salivary Gland (x35.4).

Protein differential expression in normal tissues from HIPED for GLYATL2 Gene

This gene is overexpressed in Skin (32.0) and Oral epithelium (29.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GLYATL2 Gene



Protein tissue co-expression partners for GLYATL2 Gene

NURSA nuclear receptor signaling pathways regulating expression of GLYATL2 Gene:

GLYATL2

SOURCE GeneReport for Unigene cluster for GLYATL2 Gene:

Hs.254271

mRNA Expression by UniProt/SwissProt for GLYATL2 Gene:

Q8WU03-GLYL2_HUMAN
Tissue specificity: Expressed at highest levels in salivary gland and trachea. Also detected in thyroid gland, spinal cord, prostate, lung and fetal brain.

Evidence on tissue expression from TISSUES for GLYATL2 Gene

  • Bone marrow(4)
  • Nervous system(3)
genes like me logo Genes that share expression patterns with GLYATL2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for GLYATL2 Gene

Orthologs for GLYATL2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GLYATL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GLYATL2 34 35
  • 99.77 (n)
cow
(Bos Taurus)
Mammalia GLYATL2 34 35
  • 78.95 (n)
mouse
(Mus musculus)
Mammalia Keg1 35
  • 40 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia GLYATL2 35
  • 38 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii si:dkey-76k16.5 35
  • 24 (a)
ManyToMany
Species where no ortholog for GLYATL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GLYATL2 Gene

ENSEMBL:
Gene Tree for GLYATL2 (if available)
TreeFam:
Gene Tree for GLYATL2 (if available)

Paralogs for GLYATL2 Gene

Paralogs for GLYATL2 Gene

(4) SIMAP similar genes for GLYATL2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for GLYATL2 Gene

genes like me logo Genes that share paralogs with GLYATL2: view

Variants for GLYATL2 Gene

Sequence variations from dbSNP and Humsavar for GLYATL2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000168154 -- 58,907,261(+) TGTGG(C/T)CTGTG nc-transcript-variant, upstream-variant-2KB
rs1000222601 -- 58,877,959(+) TAACT(A/G)TACTT intron-variant
rs1000313982 -- 58,871,027(+) TTTTT(A/G)TTTGA intron-variant
rs1000321676 -- 58,842,597(+) TCAGT(C/T)ACTTG intron-variant
rs1000405222 -- 58,870,717(+) CCTTG(C/T)TCCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GLYATL2 Gene

Variant ID Type Subtype PubMed ID
dgv1207n100 CNV gain 25217958
dgv71n21 CNV loss 19592680
esv3338733 CNV insertion 20981092
esv3626524 CNV loss 21293372
esv3626525 CNV gain 21293372
nsv1050013 CNV gain 25217958

Variation tolerance for GLYATL2 Gene

Residual Variation Intolerance Score: 96.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.52; 43.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GLYATL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GLYATL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLYATL2 Gene

Disorders for GLYATL2 Gene

Relevant External Links for GLYATL2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GLYATL2

No disorders were found for GLYATL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GLYATL2 Gene

Publications for GLYATL2 Gene

  1. Identification of glycine N-acyltransferase-like 2 (GLYATL2) as a transferase that produces N-acyl glycines in humans. (PMID: 20305126) Waluk D.P. … Hunt M.C. (FASEB J. 2010) 2 3 4 64
  2. Reversible lysine acetylation regulates activity of human glycine N-acyltransferase-like 2 (hGLYATL2): implications for production of glycine-conjugated signaling molecules. (PMID: 22408254) Waluk D.P. … Hunt M.C. (J. Biol. Chem. 2012) 3 4 64
  3. Designation of enzyme activity of glycine-N-acyltransferase family genes and depression of glycine-N-acyltransferase in human hepatocellular carcinoma. (PMID: 22475485) Matsuo M. … Kishimoto T. (Biochem. Biophys. Res. Commun. 2012) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3 64

Products for GLYATL2 Gene

Sources for GLYATL2 Gene

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