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Aliases for GLYATL1 Gene

Aliases for GLYATL1 Gene

  • Glycine-N-Acyltransferase Like 1 2 3 5
  • Acyl-CoA:Glycine N-Acyltransferase-Like Protein 1 3 4
  • Glutamine N-Acyltransferase 3 4
  • GNAT 3 4
  • Glycine N-Acyltransferase-Like Protein 1 3
  • Glycine-N-Acyltransferase-Like 1 2
  • EC 2.3.1.68 4
  • GATF-C 3

External Ids for GLYATL1 Gene

Previous GeneCards Identifiers for GLYATL1 Gene

  • GC11P058468
  • GC11P058696
  • GC11P055056
  • GC11P058676

Summaries for GLYATL1 Gene

GeneCards Summary for GLYATL1 Gene

GLYATL1 (Glycine-N-Acyltransferase Like 1) is a Protein Coding gene. Among its related pathways are Conjugation of carboxylic acids and Cytochrome P450 - arranged by substrate type. GO annotations related to this gene include glycine N-acyltransferase activity and glutamine N-acyltransferase activity. An important paralog of this gene is GLYATL1P3.

UniProtKB/Swiss-Prot for GLYATL1 Gene

  • Acyltransferase which transfers an acyl group to the N-terminus of glutamine. Can use phenylacetyl-CoA as an acyl donor.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLYATL1 Gene

Genomics for GLYATL1 Gene

Regulatory Elements for GLYATL1 Gene

Enhancers for GLYATL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G058925 1.2 Ensembl ENCODE 12.4 +22.6 22624 4.2 FOXA2 MLX FEZF1 ZNF2 RAD21 RARA YY1 GLIS2 SCRT2 ZNF350 GLYATL1 DTX4 FABP5P7 ENSG00000255523
GH11G059288 1.2 FANTOM5 Ensembl dbSUPER 11.3 +383.9 383854 1.7 MAX HNF4A ZSCAN29 ATF2 SPI1 YY1 OR5A2 GLYATL1 OR5AN1 OR4D6 OSBP DTX4 LOC643709 SLC25A47P1
GH11G058921 1 Ensembl ENCODE 12.4 +17.8 17831 3.3 CTCF ZNF654 SP2 KLF17 MNT EP300 RAD21 FOXA1 JUND ZNF341 GLYATL1 GLYATL2 ENSG00000255523
GH11G058904 0.9 ENCODE 11.1 +0.2 218 1.6 HDAC1 PKNOX1 SIN3A ZNF76 ZNF2 ZEB1 ZNF121 ZNF366 ZNF350 KLF7 GLYATL1 GLYATL2 ENSG00000255523
GH11G058900 1 Ensembl ENCODE 8.6 -4.6 -4568 0.9 ELF3 CTCF PKNOX1 MAX RAD21 YY1 E2F1 ZNF143 SMC3 NFYA CNTF GLYATL1 GLYATL1P2 GLYATL2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GLYATL1 on UCSC Golden Path with GeneCards custom track

Promoters for GLYATL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000039988 302 601 PKNOX1 SIN3A ZNF76 ZNF2 ZEB1 ZNF366 ZNF350 FOS KLF7 ZNF680

Genomic Location for GLYATL1 Gene

Chromosome:
11
Start:
58,905,398 bp from pter
End:
59,043,527 bp from pter
Size:
138,130 bases
Orientation:
Plus strand

Genomic View for GLYATL1 Gene

Genes around GLYATL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GLYATL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GLYATL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLYATL1 Gene

Proteins for GLYATL1 Gene

  • Protein details for GLYATL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969I3-GLYL1_HUMAN
    Recommended name:
    Glycine N-acyltransferase-like protein 1
    Protein Accession:
    Q969I3
    Secondary Accessions:
    • A6NDT0
    • Q7Z510
    • Q8NAW8

    Protein attributes for GLYATL1 Gene

    Size:
    302 amino acids
    Molecular mass:
    35101 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GLYATL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GLYATL1 Gene

Post-translational modifications for GLYATL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GLYATL1 Gene

Domains & Families for GLYATL1 Gene

Graphical View of Domain Structure for InterPro Entry

Q969I3

UniProtKB/Swiss-Prot:

GLYL1_HUMAN :
  • Belongs to the glycine N-acyltransferase family.
Family:
  • Belongs to the glycine N-acyltransferase family.
genes like me logo Genes that share domains with GLYATL1: view

No data available for Gene Families for GLYATL1 Gene

Function for GLYATL1 Gene

Molecular function for GLYATL1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Acyl-CoA + L-glutamine = CoA + N-acyl-L-glutamine.
UniProtKB/Swiss-Prot Function:
Acyltransferase which transfers an acyl group to the N-terminus of glutamine. Can use phenylacetyl-CoA as an acyl donor.

Enzyme Numbers (IUBMB) for GLYATL1 Gene

Gene Ontology (GO) - Molecular Function for GLYATL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0047946 glutamine N-acyltransferase activity IEA --
GO:0047961 glycine N-acyltransferase activity IEA --
genes like me logo Genes that share ontologies with GLYATL1: view
genes like me logo Genes that share phenotypes with GLYATL1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GLYATL1 Gene

Localization for GLYATL1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GLYATL1 gene
Compartment Confidence
nucleus 3
cytosol 3
mitochondrion 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for GLYATL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with GLYATL1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GLYATL1 Gene

Pathways & Interactions for GLYATL1 Gene

genes like me logo Genes that share pathways with GLYATL1: view

Interacting Proteins for GLYATL1 Gene

Gene Ontology (GO) - Biological Process for GLYATL1 Gene

None

No data available for SIGNOR curated interactions for GLYATL1 Gene

Drugs & Compounds for GLYATL1 Gene

(12) Drugs for GLYATL1 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glycine Approved, Vet_approved Nutra Full agonist, Agonist, Target 232
Acetylcysteine Approved, Investigational Pharma Antioxidant;mucolytic agent 330
Aminohippuric acid Approved Pharma 0
L-Glutamine Approved, Investigational Nutra Full agonist, Agonist 0
3-Hydroxyhippuric acid Experimental Pharma 0

(76) Additional Compounds for GLYATL1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with GLYATL1: view

Transcripts for GLYATL1 Gene

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for GLYATL1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d
SP1: - - - - - - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - -
SP5: - - -
SP6: - - -
SP7: - - - - - - - - - -
SP8:
SP9: - -
SP10: -

Relevant External Links for GLYATL1 Gene

GeneLoc Exon Structure for
GLYATL1
ECgene alternative splicing isoforms for
GLYATL1

Expression for GLYATL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GLYATL1 Gene

mRNA differential expression in normal tissues according to GTEx for GLYATL1 Gene

This gene is overexpressed in Liver (x33.9) and Kidney - Cortex (x16.9).

Protein differential expression in normal tissues from HIPED for GLYATL1 Gene

This gene is overexpressed in Kidney (42.4) and Liver (18.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GLYATL1 Gene



Protein tissue co-expression partners for GLYATL1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GLYATL1 Gene:

GLYATL1

SOURCE GeneReport for Unigene cluster for GLYATL1 Gene:

Hs.38085

mRNA Expression by UniProt/SwissProt for GLYATL1 Gene:

Q969I3-GLYL1_HUMAN
Tissue specificity: Expressed in liver and kidney and, at lower levels, in pancreas, testis, ovary and stomach.

Evidence on tissue expression from TISSUES for GLYATL1 Gene

  • Kidney(4.7)
  • Liver(4.5)
  • Lung(4)
genes like me logo Genes that share expression patterns with GLYATL1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for GLYATL1 Gene

Orthologs for GLYATL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GLYATL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GLYATL1 34 35
  • 99.56 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 46 (a)
OneToMany
-- 35
  • 45 (a)
OneToMany
-- 35
  • 39 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 36 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Gm4952 35
  • 36 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii si:dkey-76k16.6 35
  • 23 (a)
ManyToMany
Species where no ortholog for GLYATL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GLYATL1 Gene

ENSEMBL:
Gene Tree for GLYATL1 (if available)
TreeFam:
Gene Tree for GLYATL1 (if available)

Paralogs for GLYATL1 Gene

Paralogs for GLYATL1 Gene

(4) SIMAP similar genes for GLYATL1 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for GLYATL1 Gene

genes like me logo Genes that share paralogs with GLYATL1: view

Variants for GLYATL1 Gene

Sequence variations from dbSNP and Humsavar for GLYATL1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000105126 -- 58,949,825(+) GGGAT(A/G)CAGGA intron-variant
rs1000113372 -- 58,944,248(+) TTTGA(C/T)TAAAA intron-variant
rs1000137872 -- 58,949,502(+) GTAGG(A/T)AGTCA intron-variant
rs1000366248 -- 58,942,778(+) ATGGG(A/G)CCAGA intron-variant, upstream-variant-2KB
rs1000373132 -- 58,930,733(+) TAAGT(A/C)AATGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GLYATL1 Gene

Variant ID Type Subtype PubMed ID
dgv139e201 CNV deletion 23290073
dgv14n68 CNV gain 17160897
esv2759830 CNV gain 17122850
nsv1050013 CNV gain 25217958
nsv428258 CNV loss 18775914
nsv482929 CNV gain 15286789
nsv975934 CNV duplication 23825009

Variation tolerance for GLYATL1 Gene

Residual Variation Intolerance Score: 63.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.26; 5.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GLYATL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GLYATL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLYATL1 Gene

Disorders for GLYATL1 Gene

Relevant External Links for GLYATL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GLYATL1

No disorders were found for GLYATL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GLYATL1 Gene

Publications for GLYATL1 Gene

  1. Designation of enzyme activity of glycine-N-acyltransferase family genes and depression of glycine-N-acyltransferase in human hepatocellular carcinoma. (PMID: 22475485) Matsuo M. … Kishimoto T. (Biochem. Biophys. Res. Commun. 2012) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64
  5. Crystallographic and mass spectrometric analyses of a tandem GNAT protein from the clavulanic acid biosynthesis pathway. (PMID: 20014241) Iqbal A. … Schofield C.J. (Proteins 2010) 22 64

Products for GLYATL1 Gene

Sources for GLYATL1 Gene

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