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Aliases for GLYATL1 Gene

Aliases for GLYATL1 Gene

  • Glycine-N-Acyltransferase Like 1 2 3 5
  • Acyl-CoA:Glycine N-Acyltransferase-Like Protein 1 3 4
  • Glycine-N-Acyltransferase-Like 1 2 3
  • Glutamine N-Acyltransferase 3 4
  • GNAT 3 4
  • EC 2.3.1.68 4
  • GATF-C 3

External Ids for GLYATL1 Gene

Previous GeneCards Identifiers for GLYATL1 Gene

  • GC11P058468
  • GC11P058696
  • GC11P055056
  • GC11P058676

Summaries for GLYATL1 Gene

GeneCards Summary for GLYATL1 Gene

GLYATL1 (Glycine-N-Acyltransferase Like 1) is a Protein Coding gene. Among its related pathways are Amino Acid conjugation and Phase II conjugation. GO annotations related to this gene include glycine N-acyltransferase activity and glutamine N-acyltransferase activity. An important paralog of this gene is GLYATL3.

UniProtKB/Swiss-Prot for GLYATL1 Gene

  • Acyltransferase which transfers an acyl group to the N-terminus of glutamine. Can use phenylacetyl-CoA as an acyl donor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLYATL1 Gene

Genomics for GLYATL1 Gene

Regulatory Elements for GLYATL1 Gene

Enhancers for GLYATL1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GLYATL1 on UCSC Golden Path with GeneCards custom track

Promoters for GLYATL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GLYATL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for GLYATL1 Gene

Chromosome:
11
Start:
58,905,398 bp from pter
End:
59,043,527 bp from pter
Size:
138,130 bases
Orientation:
Plus strand

Genomic View for GLYATL1 Gene

Genes around GLYATL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GLYATL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GLYATL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLYATL1 Gene

Proteins for GLYATL1 Gene

  • Protein details for GLYATL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969I3-GLYL1_HUMAN
    Recommended name:
    Glycine N-acyltransferase-like protein 1
    Protein Accession:
    Q969I3
    Secondary Accessions:
    • A6NDT0
    • Q7Z510
    • Q8NAW8

    Protein attributes for GLYATL1 Gene

    Size:
    302 amino acids
    Molecular mass:
    35101 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GLYATL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GLYATL1 Gene

Proteomics data for GLYATL1 Gene at MOPED

Post-translational modifications for GLYATL1 Gene

No Post-translational modifications

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for GLYATL1

No data available for DME Specific Peptides for GLYATL1 Gene

Domains & Families for GLYATL1 Gene

Graphical View of Domain Structure for InterPro Entry

Q969I3

UniProtKB/Swiss-Prot:

GLYL1_HUMAN :
  • Belongs to the glycine N-acyltransferase family.
Family:
  • Belongs to the glycine N-acyltransferase family.
genes like me logo Genes that share domains with GLYATL1: view

No data available for Gene Families for GLYATL1 Gene

Function for GLYATL1 Gene

Molecular function for GLYATL1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Acyl-CoA + L-glutamine = CoA + N-acyl-L-glutamine.
UniProtKB/Swiss-Prot Function:
Acyltransferase which transfers an acyl group to the N-terminus of glutamine. Can use phenylacetyl-CoA as an acyl donor.

Enzyme Numbers (IUBMB) for GLYATL1 Gene

Gene Ontology (GO) - Molecular Function for GLYATL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0047946 glutamine N-acyltransferase activity IEA --
genes like me logo Genes that share ontologies with GLYATL1: view

Phenotypes for GLYATL1 Gene

genes like me logo Genes that share phenotypes with GLYATL1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GLYATL1 Gene

Localization for GLYATL1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GLYATL1 Gene COMPARTMENTS Subcellular localization image for GLYATL1 gene
Compartment Confidence
cytosol 3
nucleus 3
golgi apparatus 2
mitochondrion 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GLYATL1 Gene

Pathways & Interactions for GLYATL1 Gene

genes like me logo Genes that share pathways with GLYATL1: view

Interacting Proteins for GLYATL1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000300079%0d%0a9606.ENSP00000260810%0d%0a9606.ENSP00000265140%0d%0a
Selected Interacting proteins: ENSP00000300079 for GLYATL1 Gene via STRING

Gene Ontology (GO) - Biological Process for GLYATL1 Gene

None

No data available for SIGNOR curated interactions for GLYATL1 Gene

Drugs & Compounds for GLYATL1 Gene

(14) Drugs for GLYATL1 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glycine Approved Nutra Full agonist, Agonist, Target Endogenous potentiator, co-transmitter 197
Acetylcysteine Approved Pharma Antioxidant;mucolytic agent 299
Aminohippurate Approved Pharma 0
L-Glutamine Approved, Investigational Nutra Full agonist, Agonist 0
3-Hydroxyhippuric acid Experimental Pharma 0

(74) Additional Compounds for GLYATL1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with GLYATL1: view

Transcripts for GLYATL1 Gene

mRNA/cDNA for GLYATL1 Gene

(9) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(19) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for GLYATL1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d
SP1: - - - - - - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - -
SP5: - - -
SP6: - - -
SP7: - - - - - - - - - -
SP8:
SP9: - -
SP10: -

Relevant External Links for GLYATL1 Gene

GeneLoc Exon Structure for
GLYATL1
ECgene alternative splicing isoforms for
GLYATL1

Expression for GLYATL1 Gene

mRNA expression in normal human tissues for GLYATL1 Gene

mRNA differential expression in normal tissues according to GTEx for GLYATL1 Gene

This gene is overexpressed in Liver (x33.9) and Kidney - Cortex (x16.9).

Protein differential expression in normal tissues from HIPED for GLYATL1 Gene

This gene is overexpressed in Kidney (42.4) and Liver (18.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for GLYATL1 Gene



SOURCE GeneReport for Unigene cluster for GLYATL1 Gene Hs.38085

mRNA Expression by UniProt/SwissProt for GLYATL1 Gene

Q969I3-GLYL1_HUMAN
Tissue specificity: Expressed in liver and kidney and, at lower levels, in pancreas, testis, ovary and stomach.
genes like me logo Genes that share expression patterns with GLYATL1: view

Protein tissue co-expression partners for GLYATL1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for GLYATL1 Gene

Orthologs for GLYATL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GLYATL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GLYATL1 35
  • 99.56 (n)
  • 99.67 (a)
GLYATL1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 36 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 45 (a)
OneToMany
-- 36
  • 39 (a)
OneToMany
-- 36
  • 46 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Gm4952 36
  • 36 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii si:dkey-76k16.6 36
  • 23 (a)
ManyToMany
Species with no ortholog for GLYATL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GLYATL1 Gene

ENSEMBL:
Gene Tree for GLYATL1 (if available)
TreeFam:
Gene Tree for GLYATL1 (if available)

Paralogs for GLYATL1 Gene

Paralogs for GLYATL1 Gene

(4) SIMAP similar genes for GLYATL1 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for GLYATL1 Gene

genes like me logo Genes that share paralogs with GLYATL1: view

Variants for GLYATL1 Gene

Sequence variations from dbSNP and Humsavar for GLYATL1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs535218 -- 58,928,365(+) TTTCC(C/T)GGGGG intron-variant
rs538472 -- 58,930,390(-) TTCTT(A/C)TCACA intron-variant
rs550864 -- 58,926,213(-) ggcta(A/C)aacaa upstream-variant-2KB
rs573322 -- 58,928,882(-) gccct(C/T)ttggg intron-variant
rs61636378 -- 58,930,109(+) AAAAA(-/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GLYATL1 Gene

Variant ID Type Subtype PubMed ID
dgv158e201 CNV Deletion 23290073
nsv482929 CNV Gain 15286789
dgv385e1 CNV Complex 17122850
nsv428258 CNV Loss 18775914
dgv386e1 CNV Complex 17122850
dgv14n68 CNV Gain 17160897

Variation tolerance for GLYATL1 Gene

Residual Variation Intolerance Score: 63.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.26; 5.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GLYATL1 Gene

HapMap Linkage Disequilibrium report
GLYATL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLYATL1 Gene

Disorders for GLYATL1 Gene

Relevant External Links for GLYATL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GLYATL1

No disorders were found for GLYATL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GLYATL1 Gene

Publications for GLYATL1 Gene

  1. Designation of enzyme activity of glycine-N-acyltransferase family genes and depression of glycine-N-acyltransferase in human hepatocellular carcinoma. (PMID: 22475485) Matsuo M. … Kishimoto T. (Biochem. Biophys. Res. Commun. 2012) 2 3 4 67
  2. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25 26
  3. How many drug targets are there? (PMID: 17139284) Overington J.P. … Hopkins A.L. (Nat Rev Drug Discov 2006) 25 26
  4. Crystallographic and mass spectrometric analyses of a tandem GNAT protein from the clavulanic acid biosynthesis pathway. (PMID: 20014241) Iqbal A. … Schofield C.J. (Proteins 2010) 23
  5. Patt1, a novel protein acetyltransferase that is highly expressed in liver and downregulated in hepatocellular carcinoma, enhances apoptosis of hepatoma cells. (PMID: 19695338) Liu Z. … Zhai Q. (Int. J. Biochem. Cell Biol. 2009) 23

Products for GLYATL1 Gene

Sources for GLYATL1 Gene

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