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Aliases for GLYAT Gene

Aliases for GLYAT Gene

  • Glycine-N-Acyltransferase 2 3
  • ACGNAT 3 4 6
  • CAT 3 4 6
  • Aralkyl Acyl-CoA:Amino Acid N-Acyltransferase 3 4
  • Benzoyl-Coenzyme A:Glycine N-Acyltransferase 3 4
  • Acyl-CoA:Glycine N-Acyltransferase 3 4
  • Aralkyl Acyl-CoA N-Acyltransferase 3 4
  • Glycine N-Benzoyltransferase 3 4
  • EC 2.3.1.13 4 63
  • HRP-1(CLP) 3 4
  • AAc 3 4
  • GAT 3 4
  • Aralkyl-CoA N-Acyltransferase 3
  • Glycine N-Acyltransferase 3
  • EC 2.3.1.71 4

External Ids for GLYAT Gene

Previous GeneCards Identifiers for GLYAT Gene

  • GC11M060871
  • GC11M059990
  • GC11M058252
  • GC11M058251
  • GC11M058232
  • GC11M058476
  • GC11M054824

Summaries for GLYAT Gene

Entrez Gene Summary for GLYAT Gene

  • The glycine-N-acyltransferase protein conjugates glycine with acyl-CoA substrates in the mitochondria. The protein is thought to be important in the detoxification of endogenous and xenobiotic acyl-CoA's. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for GLYAT Gene

GLYAT (Glycine-N-Acyltransferase) is a Protein Coding gene. Diseases associated with GLYAT include substance-induced psychosis and osteogenesis imperfecta, type i. Among its related pathways are Metabolism and Glucose / Energy Metabolism. GO annotations related to this gene include transferase activity, transferring acyl groups and glycine N-benzoyltransferase activity. An important paralog of this gene is GLYATL3.

UniProtKB/Swiss-Prot for GLYAT Gene

  • Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate numerous substrates to form a variety of N-acylglycines, with a preference for benzoyl-CoA over phenylacetyl-CoA as acyl donors. Thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid.

Gene Wiki entry for GLYAT Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLYAT Gene

Genomics for GLYAT Gene

Regulatory Elements for GLYAT Gene

Genomic Location for GLYAT Gene

Start:
58,640,426 bp from pter
End:
58,731,974 bp from pter
Size:
91,549 bases
Orientation:
Minus strand

Genomic View for GLYAT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GLYAT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLYAT Gene

Proteins for GLYAT Gene

  • Protein details for GLYAT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IB77-GLYAT_HUMAN
    Recommended name:
    Glycine N-acyltransferase
    Protein Accession:
    Q6IB77
    Secondary Accessions:
    • O14833
    • Q96QK7

    Protein attributes for GLYAT Gene

    Size:
    296 amino acids
    Molecular mass:
    33924 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB81453.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for GLYAT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GLYAT Gene

Proteomics data for GLYAT Gene at MOPED

Selected DME Specific Peptides for GLYAT Gene

Post-translational modifications for GLYAT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GLYAT Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for GLYAT Gene

Suggested Antigen Peptide Sequences for GLYAT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6IB77

UniProtKB/Swiss-Prot:

GLYAT_HUMAN :
  • Q6IB77
Family:
  • Belongs to the glycine N-acyltransferase family.
genes like me logo Genes that share domains with GLYAT: view

No data available for Gene Families for GLYAT Gene

Function for GLYAT Gene

Molecular function for GLYAT Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=57.9 mM for benzoyl-CoA {ECO:0000269 PubMed:7802672}; KM=83.7 mM for salicyl-CoA {ECO:0000269 PubMed:7802672}; KM=124 mM for isovaleryl-CoA {ECO:0000269 PubMed:7802672}; KM=198 mM for octanoyl-CoA {ECO:0000269 PubMed:7802672}; Vmax=17.1 umol/min/mg enzyme with benzoyl-CoA as substrate {ECO:0000269 PubMed:7802672}; Vmax=10.1 umol/min/mg enzyme with salicyl-CoA as substrate {ECO:0000269 PubMed:7802672}; Vmax=7.64 umol/min/mg enzyme with isovaleryl-CoA as substrate {ECO:0000269 PubMed:7802672}; Vmax=3.3 umol/min/mg enzyme with octanoyl-CoA as substrate {ECO:0000269 PubMed:7802672};
UniProtKB/Swiss-Prot CatalyticActivity: Acyl-CoA + glycine = CoA + N-acylglycine
UniProtKB/Swiss-Prot CatalyticActivity: Benzoyl-CoA + glycine = CoA + hippurate
UniProtKB/Swiss-Prot Function: Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate numerous substrates to form a variety of N-acylglycines, with a preference for benzoyl-CoA over phenylacetyl-CoA as acyl donors. Thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid.

Enzyme Numbers (IUBMB) for GLYAT Gene

Gene Ontology (GO) - Molecular Function for GLYAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0016746 transferase activity, transferring acyl groups TAS 9202629
GO:0047961 glycine N-acyltransferase activity IEA --
GO:0047962 glycine N-benzoyltransferase activity ISS --
genes like me logo Genes that share ontologies with GLYAT: view
genes like me logo Genes that share phenotypes with GLYAT: view

miRNA for GLYAT Gene

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for GLYAT Gene

Localization for GLYAT Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLYAT Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GLYAT Gene COMPARTMENTS Subcellular localization image for GLYAT gene
Compartment Confidence
mitochondrion 5
cytosol 2
nucleus 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GLYAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion ISS --
GO:0005759 mitochondrial matrix TAS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with GLYAT: view

Pathways for GLYAT Gene

genes like me logo Genes that share pathways with GLYAT: view

Gene Ontology (GO) - Biological Process for GLYAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006544 glycine metabolic process ISS --
GO:0006637 acyl-CoA metabolic process TAS 7802672
GO:0006805 xenobiotic metabolic process TAS --
GO:0009636 response to toxic substance IEA --
GO:0032787 monocarboxylic acid metabolic process ISS --
genes like me logo Genes that share ontologies with GLYAT: view

Compounds for GLYAT Gene

(86) HMDB Compounds for GLYAT Gene

Compound Synonyms Cas Number PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate Coenzyme A
10018-95-8
(2E)-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-CoA
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate Coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
38795-33-4

(1) Drugbank Compounds for GLYAT Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Glycine
  • 2-Aminoacetic acid
56-40-6 target

(2) Novoseek inferred chemical compound relationships for GLYAT Gene

Compound -log(P) Hits PubMed IDs
benzoyl-coa 74.7 3
estrogen 0 2
genes like me logo Genes that share compounds with GLYAT: view

Transcripts for GLYAT Gene

Unigene Clusters for GLYAT Gene

Glycine-N-acyltransferase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GLYAT Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: - -
SP2: - -
SP3: -
SP4: -

Relevant External Links for GLYAT Gene

GeneLoc Exon Structure for
GLYAT
ECgene alternative splicing isoforms for
GLYAT

Expression for GLYAT Gene

mRNA expression in normal human tissues for GLYAT Gene

mRNA differential expression in normal tissues according to GTEx for GLYAT Gene

This gene is overexpressed in Liver (28.3) and Kidney - Cortex (21.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for GLYAT Gene

SOURCE GeneReport for Unigene cluster for GLYAT Gene Hs.145384

mRNA Expression by UniProt/SwissProt for GLYAT Gene

Q6IB77-GLYAT_HUMAN
Tissue specificity: Predominantly expressed in liver (at protein level) and kidney. Down-regulated in hepatocellular carcinoma and other liver cancers.
genes like me logo Genes that share expressions with GLYAT: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for GLYAT Gene

Orthologs for GLYAT Gene

This gene was present in the common ancestor of chordates.

Orthologs for GLYAT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GLYAT 35
  • 99.55 (n)
  • 99.66 (a)
GLYAT 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GLYAT 35
  • 78.87 (n)
  • 75.93 (a)
GLYAT 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GLYAT 35
  • 80.71 (n)
  • 76.37 (a)
GLYAT 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Glyat 35
  • 79.62 (n)
  • 72.64 (a)
Glyat 16
Glyat 36
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GLYAT 36
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 56 (a)
OneToMany
-- 36
  • 54 (a)
OneToMany
-- 36
  • 52 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Glyat 35
  • 80.07 (n)
  • 74.66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490041 35
  • 48.43 (n)
  • 35.83 (a)
zebrafish
(Danio rerio)
Actinopterygii si:ch73-106k19.2 36
  • 26 (a)
ManyToMany
Species with no ortholog for GLYAT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GLYAT Gene

ENSEMBL:
Gene Tree for GLYAT (if available)
TreeFam:
Gene Tree for GLYAT (if available)

Paralogs for GLYAT Gene

Paralogs for GLYAT Gene

Selected SIMAP similar genes for GLYAT Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for GLYAT Gene

genes like me logo Genes that share paralogs with GLYAT: view

Variants for GLYAT Gene

Sequence variations from dbSNP and Humsavar for GLYAT Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs473287 -- 58,711,832(-) AGCCT(C/G)TCCTT intron-variant
rs483101 -- 58,719,377(-) AAGGA(A/C)GTTAC intron-variant
rs499891 -- 58,722,748(+) CATAG(C/T)GAGGC intron-variant
rs507224 -- 58,732,506(+) CAGCA(C/T)GGTTG upstream-variant-2KB
rs520075 -- 58,727,861(+) agcag(A/G)ccact intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GLYAT Gene

Variant ID Type Subtype PubMed ID
nsv832168 CNV Gain 17160897
nsv329 CNV Loss 18451855
nsv507592 CNV Insertion 20534489
nsv330 CNV Insertion 18451855

Relevant External Links for GLYAT Gene

HapMap Linkage Disequilibrium report
GLYAT
Human Gene Mutation Database (HGMD)
GLYAT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLYAT Gene

Disorders for GLYAT Gene

(1) University of Copenhagen DISEASES for GLYAT Gene

(3) Novoseek inferred disease relationships for GLYAT Gene

Disease -log(P) Hits PubMed IDs
shock 11.2 2
necrosis 0 2
tumors 0 2

Relevant External Links for GLYAT

Genetic Association Database (GAD)
GLYAT
Human Genome Epidemiology (HuGE) Navigator
GLYAT
genes like me logo Genes that share disorders with GLYAT: view

No data available for UniProtKB/Swiss-Prot for GLYAT Gene

Publications for GLYAT Gene

  1. Purification to homogeneity of mitochondrial acyl CoA:glycine N- acyltransferase from human liver. (PMID: 7802672) Mawal Y.R. … Qureshi I.A. (Biochem. Biophys. Res. Commun. 1994) 3 4 23
  2. The utilization of alanine, glutamic acid, and serine as amino acid substrates for glycine N-acyltransferase. (PMID: 10630424) van der Westhuizen F.H. … Erasmus E. (J. Biochem. Mol. Toxicol. 2000) 3 4 23
  3. Genetic polymorphisms of glycine N-acyltransferase in Japanese individuals. (PMID: 19252341) Yamamoto A. … Azuma J. (Drug Metab. Pharmacokinet. 2009) 3 23 48
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48

Products for GLYAT Gene

Sources for GLYAT Gene

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