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Aliases for GLYAT Gene

Aliases for GLYAT Gene

  • Glycine-N-Acyltransferase 2 3 5
  • Aralkyl Acyl-CoA:Amino Acid N-Acyltransferase 3 4
  • Benzoyl-Coenzyme A:Glycine N-Acyltransferase 3 4
  • Acyl-CoA:Glycine N-Acyltransferase 3 4
  • Aralkyl Acyl-CoA N-Acyltransferase 3 4
  • Glycine N-Benzoyltransferase 3 4
  • EC 2.3.1.13 4 63
  • HRP-1(CLP) 3 4
  • ACGNAT 3 4
  • CAT 3 4
  • AAc 3 4
  • GAT 3 4
  • Aralkyl-CoA N-Acyltransferase 3
  • EC 2.3.1.71 4

External Ids for GLYAT Gene

Previous GeneCards Identifiers for GLYAT Gene

  • GC11M060871
  • GC11M059990
  • GC11M058252
  • GC11M058251
  • GC11M058232
  • GC11M058476
  • GC11M054824

Summaries for GLYAT Gene

Entrez Gene Summary for GLYAT Gene

  • The glycine-N-acyltransferase protein conjugates glycine with acyl-CoA substrates in the mitochondria. The protein is thought to be important in the detoxification of endogenous and xenobiotic acyl-CoA's. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for GLYAT Gene

GLYAT (Glycine-N-Acyltransferase) is a Protein Coding gene. Diseases associated with GLYAT include hairy tongue and substance-induced psychosis. Among its related pathways are Metabolism and Cellular Senescence. GO annotations related to this gene include transferase activity, transferring acyl groups and glycine N-benzoyltransferase activity. An important paralog of this gene is GLYATL3.

UniProtKB/Swiss-Prot for GLYAT Gene

  • Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate numerous substrates to form a variety of N-acylglycines, with a preference for benzoyl-CoA over phenylacetyl-CoA as acyl donors. Thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid.

Gene Wiki entry for GLYAT Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLYAT Gene

Genomics for GLYAT Gene

Regulatory Elements for GLYAT Gene

Genomic Location for GLYAT Gene

Chromosome:
11
Start:
58,640,426 bp from pter
End:
58,731,974 bp from pter
Size:
91,549 bases
Orientation:
Minus strand

Genomic View for GLYAT Gene

Genes around GLYAT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GLYAT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GLYAT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLYAT Gene

Proteins for GLYAT Gene

  • Protein details for GLYAT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IB77-GLYAT_HUMAN
    Recommended name:
    Glycine N-acyltransferase
    Protein Accession:
    Q6IB77
    Secondary Accessions:
    • O14833
    • Q96QK7

    Protein attributes for GLYAT Gene

    Size:
    296 amino acids
    Molecular mass:
    33924 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB81453.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for GLYAT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GLYAT Gene

Proteomics data for GLYAT Gene at MOPED

Selected DME Specific Peptides for GLYAT Gene

Post-translational modifications for GLYAT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GLYAT Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for GLYAT

Domains & Families for GLYAT Gene

Suggested Antigen Peptide Sequences for GLYAT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6IB77

UniProtKB/Swiss-Prot:

GLYAT_HUMAN :
  • Belongs to the glycine N-acyltransferase family.
Family:
  • Belongs to the glycine N-acyltransferase family.
genes like me logo Genes that share domains with GLYAT: view

No data available for Gene Families for GLYAT Gene

Function for GLYAT Gene

Molecular function for GLYAT Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=57.9 mM for benzoyl-CoA {ECO:0000269 PubMed:7802672}; KM=83.7 mM for salicyl-CoA {ECO:0000269 PubMed:7802672}; KM=124 mM for isovaleryl-CoA {ECO:0000269 PubMed:7802672}; KM=198 mM for octanoyl-CoA {ECO:0000269 PubMed:7802672}; Vmax=17.1 umol/min/mg enzyme with benzoyl-CoA as substrate {ECO:0000269 PubMed:7802672}; Vmax=10.1 umol/min/mg enzyme with salicyl-CoA as substrate {ECO:0000269 PubMed:7802672}; Vmax=7.64 umol/min/mg enzyme with isovaleryl-CoA as substrate {ECO:0000269 PubMed:7802672}; Vmax=3.3 umol/min/mg enzyme with octanoyl-CoA as substrate {ECO:0000269 PubMed:7802672};
UniProtKB/Swiss-Prot CatalyticActivity:
Acyl-CoA + glycine = CoA + N-acylglycine.
UniProtKB/Swiss-Prot CatalyticActivity:
Benzoyl-CoA + glycine = CoA + hippurate.
UniProtKB/Swiss-Prot Function:
Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate numerous substrates to form a variety of N-acylglycines, with a preference for benzoyl-CoA over phenylacetyl-CoA as acyl donors. Thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid.

Enzyme Numbers (IUBMB) for GLYAT Gene

genes like me logo Genes that share phenotypes with GLYAT: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GLYAT

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GLYAT Gene

Localization for GLYAT Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLYAT Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GLYAT Gene COMPARTMENTS Subcellular localization image for GLYAT gene
Compartment Confidence
extracellular 5
mitochondrion 5
cytosol 2
nucleus 2
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for GLYAT Gene

Pathways & Interactions for GLYAT Gene

genes like me logo Genes that share pathways with GLYAT: view

Gene Ontology (GO) - Biological Process for GLYAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process TAS --
GO:0008152 metabolic process IEA --
GO:0032787 monocarboxylic acid metabolic process ISS --
genes like me logo Genes that share ontologies with GLYAT: view

No data available for SIGNOR curated interactions for GLYAT Gene

Drugs & Compounds for GLYAT Gene

(14) Drugs for GLYAT Gene - From: HMDB, Novoseek, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glycine Approved Nutra Full agonist, Agonist, Target Endogenous potentiator, co-transmitter 94
Acetylcysteine Approved Pharma Antioxidant;mucolytic agent 293
Aminohippurate Approved Pharma 0
3-Hydroxyhippuric acid Experimental Pharma 0
Acetylglycine Experimental Pharma 0

(76) Additional Compounds for GLYAT Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
benzoyl-coa
  • Benzoyl CoA
  • Benzoyl Coenzyme A
  • Benzoyl-S-CoA
  • Benzoyl-S-Coenzyme A
  • S-Benzoate
6756-74-7
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
genes like me logo Genes that share compounds with GLYAT: view

Transcripts for GLYAT Gene

Unigene Clusters for GLYAT Gene

Glycine-N-acyltransferase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GLYAT Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: - -
SP2: - -
SP3: -
SP4: -

Relevant External Links for GLYAT Gene

GeneLoc Exon Structure for
GLYAT
ECgene alternative splicing isoforms for
GLYAT

Expression for GLYAT Gene

mRNA expression in normal human tissues for GLYAT Gene

mRNA differential expression in normal tissues according to GTEx for GLYAT Gene

This gene is overexpressed in Liver (x28.3) and Kidney - Cortex (x21.4).

Protein differential expression in normal tissues from HIPED for GLYAT Gene

This gene is overexpressed in Liver (25.1), Liver, secretome (20.3), and Kidney (16.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GLYAT Gene



SOURCE GeneReport for Unigene cluster for GLYAT Gene Hs.145384

mRNA Expression by UniProt/SwissProt for GLYAT Gene

Q6IB77-GLYAT_HUMAN
Tissue specificity: Predominantly expressed in liver (at protein level) and kidney. Down-regulated in hepatocellular carcinoma and other liver cancers.
genes like me logo Genes that share expression patterns with GLYAT: view

Protein tissue co-expression partners for GLYAT Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for GLYAT Gene

Orthologs for GLYAT Gene

This gene was present in the common ancestor of chordates.

Orthologs for GLYAT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GLYAT 35
  • 99.55 (n)
  • 99.66 (a)
GLYAT 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GLYAT 36
  • 76 (a)
OneToOne
GLYAT 35
  • 78.87 (n)
  • 75.93 (a)
dog
(Canis familiaris)
Mammalia GLYAT 35
  • 80.71 (n)
  • 76.37 (a)
GLYAT 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Glyat 16
Glyat 36
  • 73 (a)
OneToOne
Glyat 35
  • 79.62 (n)
  • 72.64 (a)
oppossum
(Monodelphis domestica)
Mammalia GLYAT 36
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 56 (a)
OneToMany
-- 36
  • 54 (a)
OneToMany
-- 36
  • 52 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Glyat 35
  • 80.07 (n)
  • 74.66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490041 35
  • 48.43 (n)
  • 35.83 (a)
zebrafish
(Danio rerio)
Actinopterygii si:ch73-106k19.2 36
  • 26 (a)
ManyToMany
Species with no ortholog for GLYAT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GLYAT Gene

ENSEMBL:
Gene Tree for GLYAT (if available)
TreeFam:
Gene Tree for GLYAT (if available)

Paralogs for GLYAT Gene

Paralogs for GLYAT Gene

(4) SIMAP similar genes for GLYAT Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for GLYAT Gene

genes like me logo Genes that share paralogs with GLYAT: view

Variants for GLYAT Gene

Sequence variations from dbSNP and Humsavar for GLYAT Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10896818 - 58,724,448(+) CAAGG(A/T)TTTCT reference, missense
rs675815 - 58,710,611(+) CACCA(C/T)TGGGA reference, missense
rs507224 -- 58,732,506(+) CAGCA(C/T)GGTTG upstream-variant-2KB
rs520075 -- 58,727,861(+) agcag(A/G)ccact intron-variant
rs528136 -- 58,713,265(-) AGAAT(A/T)CAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GLYAT Gene

Variant ID Type Subtype PubMed ID
nsv832168 CNV Gain 17160897
nsv329 CNV Loss 18451855
nsv507592 CNV Insertion 20534489
nsv330 CNV Insertion 18451855

Variation tolerance for GLYAT Gene

Residual Variation Intolerance Score: 88.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.71; 46.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GLYAT Gene

HapMap Linkage Disequilibrium report
GLYAT
Human Gene Mutation Database (HGMD)
GLYAT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLYAT Gene

Disorders for GLYAT Gene

MalaCards: The human disease database

(7) MalaCards diseases for GLYAT Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hairy tongue
  • overgrowth of filiform papillae
substance-induced psychosis
osteogenesis imperfecta, type i
  • osteogenesis imperfecta type i
isovaleric acidemia
  • isovaleric acid coa dehydrogenase deficiency
fissured tongue
  • congenital fissure of tongue
- elite association - COSMIC cancer census association via MalaCards
Search GLYAT in MalaCards View complete list of genes associated with diseases

Relevant External Links for GLYAT

Genetic Association Database (GAD)
GLYAT
Human Genome Epidemiology (HuGE) Navigator
GLYAT
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GLYAT
genes like me logo Genes that share disorders with GLYAT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GLYAT Gene

Publications for GLYAT Gene

  1. Purification to homogeneity of mitochondrial acyl CoA:glycine N- acyltransferase from human liver. (PMID: 7802672) Mawal Y.R. … Qureshi I.A. (Biochem. Biophys. Res. Commun. 1994) 3 4 23 67
  2. Genetic polymorphisms of glycine N-acyltransferase in Japanese individuals. (PMID: 19252341) Yamamoto A. … Azuma J. (Drug Metab. Pharmacokinet. 2009) 3 23
  3. Frequent genetic alterations and reduced expression of the Axin1 gene in oral squamous cell carcinoma: involvement in tumor progression and metastasis. (PMID: 17143481) Zhou C.X. … Gao Y. (Oncol. Rep. 2007) 25 26
  4. An efficient method for homologous gene reconstitution in Cryptococcus gattii using URA5 auxotrophic marker. (PMID: 17146584) Narasipura S.D. … Chaturvedi S. (Mycopathologia 2006) 25 26
  5. The utilization of alanine, glutamic acid, and serine as amino acid substrates for glycine N-acyltransferase. (PMID: 10630424) van der Westhuizen F.H. … Erasmus E. (J. Biochem. Mol. Toxicol. 2000) 3 23

Products for GLYAT Gene

Sources for GLYAT Gene

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