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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GLYAT Gene

protein-coding   GIFtS: 63
GCID: GC11M058476

Glycine-N-Acyltransferase

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
glycine-N-acyltransferase1 2     AAc2 3
ACGNAT2 3 5     GAT2 3
CAT2 3 5     HRP-1(CLP)2 3
Acyl-CoA:Glycine N-Acyltransferase2 3     EC 2.3.1.133 8
Aralkyl Acyl-CoA N-Acyltransferase2 3     Aralkyl-CoA N-Acyltransferase2
Aralkyl Acyl-CoA:Amino Acid N-Acyltransferase2 3     Glycine N-Acyltransferase2
Benzoyl-Coenzyme A:Glycine N-Acyltransferase2 3     EC 2.3.1.713
Glycine N-Benzoyltransferase2 3     

External Ids:    HGNC: 137341   Entrez Gene: 102492   Ensembl: ENSG000001491247   OMIM: 6074245   UniProtKB: Q6IB773   

Export aliases for GLYAT gene to outside databases

Previous GC identifers: GC11M060871 GC11M059990 GC11M058727 GC11M058252 GC11M058251 GC11M058232 GC11M054824


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GLYAT Gene:
The glycine-N-acyltransferase protein conjugates glycine with acyl-CoA substrates in the mitochondria. The protein
is thought to be important in the detoxification of endogenous and xenobiotic acyl-CoA's. Two transcript variants
encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for GLYAT Gene: 
GLYAT (glycine-N-acyltransferase) is a protein-coding gene. Diseases associated with GLYAT include osteogenesis imperfecta type i, and osteogenesis imperfecta, and among its related super-pathways are Phase II conjugation and Conjugation of salicylate with glycine. GO annotations related to this gene include glycine N-benzoyltransferase activity and transferase activity, transferring acyl groups. An important paralog of this gene is GLYATL1.

UniProtKB/Swiss-Prot: GLYAT_HUMAN, Q6IB77
Function: Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine,
although much less efficiently. Can conjugate numerous substrates to form a variety of N-acylglycines, with a
preference for benzoyl-CoA over phenylacetyl-CoA as acyl donors. Thereby detoxify xenobiotics, such as benzoic
acid or salicylic acid, and endogenous organic acids, such as isovaleric acid

Gene Wiki entry for GLYAT Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GLYAT gene promoter:
         HOXA9B   RP58   p53   POU6F1 (c2)   Tal-1beta   E47   ARP-1   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): GLYAT promoter sequence
   Search SABiosciences Chromatin IP Primers for GLYAT

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GLYAT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.1   Ensembl cytogenetic band:  11q12.1   HGNC cytogenetic band: 11q12.1

GLYAT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GLYAT gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M058476:  view genomic region     (about GC identifiers)

Start:
58,407,899 bp from pter      End:
58,499,447 bp from pter
Size:
91,549 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GLYAT_HUMAN, Q6IB77 (See protein sequence)
Recommended Name: Glycine N-acyltransferase  
Size: 296 amino acids; 33924 Da
Subcellular location: Mitochondrion
Sequence caution: Sequence=AAB81453.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: O14833 Q96QK7
Alternative splicing: 2 isoforms:  Q6IB77-1   Q6IB77-2   

Explore the universe of human proteins at neXtProt for GLYAT: NX_Q6IB77

Explore proteomics data for GLYAT at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6IB77

  • 4 DME Specific Peptides for GLYAT (Q6IB77)
     QMLQMLE  WHFGGNE  CLLGPEGTP  INWKQHLQIQSSQ 

    GLYAT Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GLYAT Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_005829.3  NP_964011.2  

    ENSEMBL proteins: 
     ENSP00000468512   ENSP00000340200   ENSP00000431688   ENSP00000278400  
    Reactome Protein details: Q6IB77
    Human Recombinant Protein Products for GLYAT: 
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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ISS--
    GO:0005759mitochondrial matrix TAS--

    GLYAT for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for GLYAT


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR016181 Acyl_CoA_acyltransferase
     IPR015938 Glycine_N-acyltransferase_N
     IPR010313 Glycine_N-acyltransferase
     IPR013652 Glycine_N-acyltransferase_C

    Graphical View of Domain Structure for InterPro Entry Q6IB77

    ProtoNet protein and cluster: Q6IB77

    UniProtKB/Swiss-Prot: GLYAT_HUMAN, Q6IB77
    Similarity: Belongs to the glycine N-acyltransferase family


    GLYAT for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GLYAT_HUMAN, Q6IB77
    Function: Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine,
    although much less efficiently. Can conjugate numerous substrates to form a variety of N-acylglycines, with a
    preference for benzoyl-CoA over phenylacetyl-CoA as acyl donors. Thereby detoxify xenobiotics, such as benzoic
    acid or salicylic acid, and endogenous organic acids, such as isovaleric acid
    Catalytic activity: Acyl-CoA + glycine = CoA + N-acylglycine
    Catalytic activity: Benzoyl-CoA + glycine = CoA + hippurate
    Biophysicochemical properties: Kinetic parameters: KM=57.9 mM for benzoyl-CoA; KM=83.7 mM for salicyl-CoA; KM=124
    mM for isovaleryl-CoA; KM=198 mM for octanoyl-CoA; Vmax=17.1 umol/min/mg enzyme with benzoyl-CoA as substrate;
    Vmax=10.1 umol/min/mg enzyme with salicyl-CoA as substrate; Vmax=7.64 umol/min/mg enzyme with isovaleryl-CoA as
    substrate; Vmax=3.3 umol/min/mg enzyme with octanoyl-CoA as substrate;

         Enzyme Numbers (IUBMB): EC 2.3.1.131 2 EC 2.3.1.711

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016746transferase activity, transferring acyl groups TAS9202629
    GO:0047961glycine N-acyltransferase activity IEA--
    GO:0047962glycine N-benzoyltransferase activity ISS--
         
    GLYAT for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for GLYAT:
     Decreased Wnt reporter activit  Increased number of cells in m 

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidGLYAT 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GLYAT About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Biological oxidations
    Biological oxidations0.55
    metapathway biotransformation0.41
    Phase II conjugation0.55
    2Amino Acid conjugation
    Amino Acid conjugation0.67
    Conjugation of carboxylic acids0.67
    Conjugation of benzoate with glycine0.67
    Conjugation of salicylate with glycine0.67
    3Metabolism
    Metabolism0.40
    4Phenylalanine metabolism
    Phenylalanine metabolism0.36
    5Amino acid conjugation of benzoic acid
    Amino acid conjugation of benzoic acid

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for GLYAT
        Amino acid conjugation of benzoic acid
    metapathway biotransformation


    5/7        Reactome Pathways for GLYAT (see all 7)
        Conjugation of carboxylic acids
    Conjugation of benzoate with glycine
    Metabolism
    Biological oxidations
    Amino Acid conjugation


    1         Kegg Pathway  (Kegg details for GLYAT):
        Phenylalanine metabolism


    GLYAT for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GLYAT

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5/8 Interacting proteins for GLYAT (Q6IB772, 3 ENSP000003402004) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTNP212462, 3, ENSP000003411704MINT-63081 I2D: score=5 STRING: ENSP00000341170
    GPRASP1Q5JY772, 3MINT-63082 I2D: score=4 
    RBM48Q5RL733I2D: score=4 
    MDFIQ997503I2D: score=1 
    VOPP1Q96AW13I2D: score=1 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006544glycine metabolic process ISS--
    GO:0006637acyl-CoA metabolic process TAS7802672
    GO:0006805xenobiotic metabolic process TAS--
    GO:0009636response to toxic substance IEA--
    GO:0032787monocarboxylic acid metabolic process ISS--

    GLYAT for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GLYAT for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GLYAT

    10/86 HMDB Compounds for GLYAT (see all 86)    About this table
    CompoundSynonyms CAS #PubMed Ids
    IsovalerylsarcosineN-Isovalerylsarcosine 88127-29-16197208
    (2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
    (2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    (2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
    (2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
    2-Furoylglycine2-Furoylglycine (see all 11)5657-19-2--
    2-Methylbutyryl-CoA2-methylbutanoyl-CoA (see all 11)6712-02-3--
    2-Methylbutyrylglycine(2-methyl-butyrylamino)-acetate (see all 7)52320-67-9--
    2-Methylhexanoyl-CoA2-Methylhexanoyl-CoEnzyme A (see all 5)----

    1 DrugBank Compound for GLYAT    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Glycine2-Aminoacetic acid (see all 4)56-40-6target--17146584 17143481

    2 Novoseek inferred chemical compound relationships for GLYAT gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    benzoyl-coa 74.7 3 10630424 (2), 7802672 (1)
    estrogen 0 4 1779966 (1), 7517003 (1)

    Search CenterWatch for drugs/clinical trials and news about GLYAT

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GLYAT gene (2 alternative transcripts): 
    NM_005838.3  NM_201648.2  

    Unigene Cluster for GLYAT:

    Glycine-N-acyltransferase
    Hs.145384  [show with all ESTs]
    Unigene Representative Sequence: NM_201648
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000586098 ENST00000344743(uc001nnb.3) ENST00000529732 ENST00000278400(uc001nnc.3)
    ENST00000531084
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    Additional mRNA sequence: 

    AB665285.1 AF023466.1 BC009785.1 CR456927.1 

    4 DOTS entries:

    DT.313485  DT.92428156  DT.92428155  DT.75131930 

    24/87 AceView cDNA sequences (see all 87):

    AI521852 AI244067 AW024233 AI478457 NM_005838 AI253073 AI431833 NM_201648 
    AI522080 AW237450 AI991367 BX091574 BG431164 BG428674 CB161978 BG617573 
    BG432506 BG433395 AV645604 AA707305 AV645422 BG432065 BE501752 AW772320 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for GLYAT    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b
    SP1:                    -           -                                 
    SP2:                    -           -                                 
    SP3:                                -                                 
    SP4:                    -                                             


    ECgene alternative splicing isoforms for GLYAT

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GLYAT expression in normal human tissues (normalized intensities)      GLYAT embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    GLYAT Expression
    About this image


    GLYAT expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Pancreas (Endocrine System)
             Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...
     
     Adipose (Muscoskeletal System)
             adipose tissue   
     
     Liver (Hepatobiliary System)
     
     Kidney (Urinary System)

    See GLYAT Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GLYAT

    SOURCE GeneReport for Unigene cluster: Hs.145384

    UniProtKB/Swiss-Prot: GLYAT_HUMAN, Q6IB77
    Tissue specificity: Predominantly expressed in liver (at protein level) and kidney. Down-regulated in
    hepatocellular carcinoma and other liver cancers

        SABiosciences Expression via Pathway-Focused PCR Array including GLYAT: 
              Drug Metabolism: Phase II Enzymes in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for GLYAT gene from 2/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Glyat1 , 5 glycine-N-acyltransferase1, 5 79.62(n)1
    72.64(a)1
      19 (8.73 cM)5
    1071461  NM_145935.31  NP_666047.11 
     126333085 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-76k16.56
    CU459094.16
    (see all 3)
    Uncharacterized protein
    (see all 3)
    26(a)
    25(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    13(33889503-33892397)
    11(43800837-43810687)


    ENSEMBL Gene Tree for GLYAT (if available)
    TreeFam Gene Tree for GLYAT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GLYAT gene
    GLYATL12  GLYATL32  GLYATL22  
    5 SIMAP similar genes for GLYAT using alignment to 2 protein entries:     GLYAT_HUMAN (see all proteins):
    GLYATL1    GATF-C    GATF-B    GLYATL2    GLYATL3

    GLYAT for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for GLYAT
    PGOHUM00000242304 PGOHUM00000242742


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/575 SNPs in GLYAT are shown (see all 575)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1399877041,2
    C--58475754(+) CAGCAA/CGAAAC 1 -- int10--------
    rs1139343051,2
    C--58475775(+) AAAAG-/AAAAAA 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs776965941,2
    C,F--58475820(+) GAAAGA/TTTATC 1 -- int11Minor allele frequency- T:0.04EA 120
    rs593731941,2
    C--58475844(+) CTCAAC/TTGACT 1 -- int13Minor allele frequency- T:0.15WA CSA 121
    rs1908723291,2
    --58476038(+) TTGTGA/CCTGAA 1 -- int10--------
    rs797228291,2
    C,F--58476185(+) AGACAC/TCAAAT 1 -- int11Minor allele frequency- T:0.05EA 120
    rs1825865101,2
    --58476186(+) GACACA/CAAATC 1 -- int10--------
    rs1159095311,2
    F--58476212(+) TTTAGA/GCTTCC 1 -- int11Minor allele frequency- G:0.02WA 118
    rs1438954661,2
    C--58476384(+) GGTGTC/TCATGC 1 -- ut310--------
    rs773374611,2
    C,F--58476455(+) GTGCTC/TCCACC 1 -- ut311Minor allele frequency- T:0.04NA 120

    HapMap Linkage Disequilibrium report for GLYAT (58407899 - 58499447 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for GLYAT:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv330CNV Insertion18451855
    nsv507592CNV Insertion20534489
    nsv329CNV Loss18451855
    nsv832168CNV Gain17160897


    Human Gene Mutation Database (HGMD): GLYAT
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing GLYAT
    DNA2.0 Custom Variant and Variant Library Synthesis for GLYAT

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607424    OMIM disorders: --

    10 diseases for GLYAT:    About MalaCards
    osteogenesis imperfecta type i    osteogenesis imperfecta    bullous pemphigoid    pertussis
    intrahepatic cholangiocarcinoma    cholangiocarcinoma    glioblastoma    neuroblastoma
    hepatocellular carcinoma    breast cancer

    1 disease from the University of Copenhagen DISEASES database for GLYAT:
    substance-induced psychosis

    GLYAT for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for GLYAT gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 11.2 2 14673135 (1), 9548565 (1)
    necrosis 0 2 7891669 (2)
    tumors 0 2 7891669 (2)

    Genetic Association Database (GAD): GLYAT
    Human Genome Epidemiology (HuGE) Navigator: GLYAT (3 documents)

    Export disorders for GLYAT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GLYAT gene, integrated from 9 sources (see all 47):
    (articles sorted by number of sources associating them with GLYAT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Purification to homogeneity of mitochondrial acyl CoA:glycine N- acyltransferase from human liver. (PubMed id 7802672)1, 2, 9 Mawal Y.R. and Qureshi I.A. (1994)
    2. The utilization of alanine, glutamic acid, and serine as amino acid substrates for glycine N-acyltransferase. (PubMed id 10630424)1, 2, 9 van der Westhuizen F.H.... Erasmus E. (2000)
    3. Genetic polymorphisms of glycine N-acyltransferase in Japanese individuals. (PubMed id 19252341)1, 4, 9 Yamamoto A....Azuma J. (2009)
    4. Designation of enzyme activity of glycine-N-acyltransferase family genes and depression of glycine-N-acyltransferase in human hepatocellular carcinoma. (PubMed id 22475485)1, 2 Matsuo M.... Kishimoto T. (2012)
    5. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Developmental profile of mitochondrial glycine N-acyltransferase in human liver. (PubMed id 9202629)1, 9 Mawal Y....Qureshi I.A. (1997)
    8. An immunodetection method for the quantitation of human acyl CoA:glycine N-acyltransferase in biological samples. (PubMed id 7833837)1, 9 Mawal Y.R. and Qureshi I.A. (1994)
    9. Fatty acid amide biosynthesis: a possible new role for peptidylglycine alpha-amidating enzyme and acyl-coenzyme A: glycine N-acyltransferase. (PubMed id 8660675)1, 9 Merkler D.J....Fleming F.F. (1996)
    10. Characterisation of the influence of genetic variation s on the enzyme activity of a recombinant human glycine N-acyltransferase. (PubMed id 23237781)1 van der Sluis R....van Dijk A.A. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10249 HGNC: 13734 AceView: GLYAT Ensembl:ENSG00000149124 euGenes: HUgn10249
    ECgene: GLYAT Kegg: 10249 H-InvDB: GLYAT

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GLYAT Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GLYAT gene:
    Search GeneIP for patents involving GLYAT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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