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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

GLUL Gene

protein-coding GIFtS: 70
GCID: GC01M182350

glutamate-ammonia ligase

(Previous name: glutamate-ammonia ligase (glutamine synthase) )
(Previous symbol: GLNS)

Explore 73 diseases affiliated with
GLUL via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Glutamate-Ammonia Ligase¹ ²		PIG43²
GLNS¹ ² ³ ⁵		PIG59²
Glutamate Decarboxylase² ³		Cell Proliferation-Inducing Protein 59²
Glutamate--Ammonia Ligase² ³		Glutamine Synthase²
GS² ³		Glutamine Synthetase²
EC 6.3.1.2³ ⁸		Proliferation-Inducing Protein 43²
Glutamate-Ammonia Ligase (Glutamine Synthase)¹		EC 4.1.1.15³

External Ids:	HGNC: 4341¹	Entrez Gene: 2752²	Ensembl: ENSG00000135821⁷	OMIM: 138290⁵	UniProtKB: P15104³

Export aliases for GLUL gene to outside databases

Previous GC identifers: GC01M179878 GC01M177780 GC01M178872 GC01M179592 GC01M179593 GC01M179083 GC01M180617 GC01M153587

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GLUL:

The protein encoded by this gene belongs to the glutamine synthetase family. It catalyzes the synthesis of glutamine

from glutamate and ammonia. Glutamine is a main source of energy and is involved in cell proliferation, inhibition of

apoptosis, and cell signaling. This gene is expressed during early fetal stages, and plays an important role in

controlling body pH by removing ammonia from circulation. Mutations in this gene are associated with congenital

glutamine deficiency. Several alternatively spliced transcript variants have been found for this gene.(provided by

RefSeq, Oct 2009)

UniProtKB/Swiss-Prot: GLNA_HUMAN, P15104

Function: This enzyme has 2 functions: it catalyzes the production of glutamine and 4-aminobutanoate

(gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner (By similarity). Essential for

proliferation of fetal skin fibroblasts

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004487.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the GLUL gene promoter:
ATF-2 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): GLUL promoter sequence

Search SABiosciences Chromatin IP Primers for GLUL

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GLUL

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q31 Ensembl cytogenetic band: 1q25.3 HGNC cytogenetic band: 1q31

GLUL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GLUL gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M182350: view genomic region (about GC identifiers)

Start:	182,350,839 bp from pter	End:	182,361,341 bp from pter
Size:	10,503 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: GLNA_HUMAN, P15104 (See protein sequence)

Recommended Name: Glutamine synthetase

Size: 373 amino acids; 42064 Da

Cofactor: Biotin (By similarity)

Cofactor: Magnesium or manganese (By similarity)

Subunit: Homooctamer and homotetramer. Interacts with PALMD (By similarity)

Subcellular location: Cytoplasm. Mitochondrion (By similarity)

Developmental stage: Expressed during early fetal stages

2 PDB 3D structures from and Proteopedia for GLUL:

2OJW (3D)

2QC8 (3D)

Secondary accessions: Q499Y9 Q5T9Z1 Q7Z3W4 Q8IZ17

Explore the universe of human proteins at neXtProt for GLUL: NX_P15104

Post-translational modifications:

Ubiquitinated by ZNRF1 (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P15104

4/24 DME Specific Peptides for GLUL (P15104) (see all 24)

GFPGPQG

GTNAEVM

YIWIDGT

PQGPYYC

GLUL Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001028216.1 NP_001028228.1 NP_002056.2

ENSEMBL proteins:

ENSP00000356537 ENSP00000344958 ENSP00000307900 ENSP00000398320

Reactome Protein details: P15104
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Proteins (see all 3): GLUL OriGene Protein Over-expression Lysate (see all 4): GLUL OriGene Custom Protein Services for GLUL
	GenScript Custom Purified and Recombinant Proteins Services for GLUL
	Novus Biologicals GLUL Proteins Novus Biologicals GLUL Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for GLUL
	Uscn Proteins for GLUL

Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005737	cytoplasm	--	--
GO:0005739	mitochondrion	IEA	--
GO:0005791	rough endoplasmic reticulum	IEA	--
GO:0005794	Golgi apparatus	--	--

GLUL for ontologies About GeneDecksing

GLUL Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of GLUL
	Browse R&D Systems for Antibodies
	OriGene Antibodies (see all 2): GLUL OriGene Custom Antibody Services for GLUL
	GenScript Custom Superior Antibodies Services for GLUL
	Novus Biologicals GLUL Antibodies
	Abcam antibodies for GLUL
	Uscn Antibodies for GLUL
	ThermoFisher Antibody for GLUL

Assay Products for GLUL:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for GLUL
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for GLUL

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

GLUL for domains About GeneDecksing

3 InterPro domains/families:

IPR008147 Gln_synt_beta

IPR014746 Gln_synth/guanido_kin_cat_dom

IPR008146 Gln_synth_cat_dom

Graphical View of Domain Structure for InterPro Entry P15104

ProtoNet protein and cluster: P15104

UniProtKB/Swiss-Prot: GLNA_HUMAN, P15104

Similarity: Belongs to the glutamine synthetase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: GLNA_HUMAN, P15104

Function: This enzyme has 2 functions: it catalyzes the production of glutamine and 4-aminobutanoate

(gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner (By similarity). Essential for

proliferation of fetal skin fibroblasts

Catalytic activity: ATP + L-glutamate + NH(3) = ADP + phosphate + L-glutamine

Catalytic activity: L-glutamate = 4-aminobutanoate + CO(2)

Induction: By glucocorticoids. Vitamin D and the Wnt signaling pathway inhibit its expression and activity

Genatlas biochemistry entry for GLUL:

L-glutamine synthetase

Enzyme Numbers (IUBMB): EC 6.3.1.2¹ ² EC 4.1.1.15¹

miRNA Products:		miRTarBase miRNAs that target GLUL: hsa-mir-29a (MIRT004021)

		OriGene 3'-UTR Clone (see all 3): GLUL Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GLUL
		8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate GLUL (see all 22):
		hsa-miR-140-5p hsa-miR-582-3p hsa-miR-3607-3p hsa-miR-4286 hsa-miR-1285 hsa-miR-340 hsa-miR-3170 hsa-miR-497*

		SwitchGear 3'UTR luciferase reporter plasmid: GLUL 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GLUL (see all 7) OriGene shRNA RFP: GLUL OriGene siRNA: GLUL
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GLUL

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for GLUL

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GLUL (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GLUL (see all 5) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): GLUL (NM_002065)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for GLUL
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GLUL

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for GLUL
		Search LifeMap BioReagents cell lines for GLUL

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GLUL

Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000287	magnesium ion binding	IEA	--
GO:0004351	glutamate decarboxylase activity	IEA	--
GO:0004356	glutamate-ammonia ligase activity	EXP	--
GO:0005515	protein binding	--	--
GO:0005524	ATP binding	IEA	--

GLUL for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for GLUL:

Increased G1 DNA content

Increased cell death HMECs cel

Animal Models:
5 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Glul):

behavior/neurological

growth/size

homeostasis/metabolism

mortality/aging

nervous system

GLUL for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Neurotransmitter uptake and Metabolism In Glial Cells

	Astrocytic Glutamate-Glutamine Uptake And Metabolism	1.00			glutamine biosynthesis I	0.25
	Neurotransmitter uptake and Metabolism In Glial Cells	1.00

Transmission across Chemical Synapses

Transmission across Chemical Synapses

1.00

Neuronal System

0.67

Metabolism

Metabolism

1.00

Metabolic pathways

0.38

Amino acid synthesis and interconversion (transamination)

Amino acid synthesis and interconversion (transamination)

1.00

Metabolism of amino acids and derivatives

Metabolism of amino acids and derivatives

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for GLUL

	Selected targets of GCR-alpha
	Glutamic acid signaling

1 BioSystems Pathway for GLUL

glutamine biosynthesis I

5/7 Reactome Pathways for GLUL (see all 7)

	Transmission across Chemical Synapses
	Astrocytic Glutamate-Glutamine Uptake And Metabolism
	Metabolism
	Amino acid synthesis and interconversion (transamination)
	Metabolism of amino acids and derivatives

5 Kegg Pathways (Kegg details for GLUL):

	Alanine, aspartate and glutamate metabolism
	Arginine and proline metabolism
	Nitrogen metabolism
	Metabolic pathways
	Glutamatergic synapse

GLUL for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for GLUL

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/140 Interacting proteins for GLUL (P15104^{1, 2, 3} ENSP00000307900⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 140)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SKIL	P12757²^,³	MINT-61661 I2D: score=3
GLUL	P15104¹^,²	EBI-746653,EBI-746653 MINT-68068
NUDT18	Q6ZVK8²^,³, ENSP00000307852⁴	MINT-68171 I2D: score=5 STRING: ENSP00000307852
PLEKHF2	Q9H8W4²^,³, ENSP00000322373⁴	MINT-66879 I2D: score=5 STRING: ENSP00000322373
PIAS1	O75925³, ENSP00000249636⁴	I2D: score=3 STRING: ENSP00000249636

About this table

Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001504	neurotransmitter uptake	TAS	--
GO:0006538	glutamate catabolic process	TAS	--
GO:0006542	glutamine biosynthetic process	TAS	--
GO:0007268	synaptic transmission	TAS	--
GO:0008283	cell proliferation	IDA	18662667

GLUL for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

GLUL for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Enzo Life Sciences drugs & compounds for GLUL

Browse Tocris compounds for GLUL

2 HMDB Compounds for GLUL About this table

Compound	Synonyms	CAS #	PubMed Ids
L-Glutamic acid	(2S)-2-Aminopentanedioate (see all 49)	56-86-0	--
L-Glutamine	(2S)-2,5-diamino-5-oxopentanoic acid (see all 31)	56-85-9	--

8 DrugBank Compounds for GLUL About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
L-Glutamine	(S)-2,5-diamino-5-oxopentanoic acid (see all 4)	56-85-9	target	product of	16484281 16326016 16547651 16382338 16530878
L-Glutamic Acid	(2S)-2-Aminopentanedioic acid (see all 15)	56-86-0	target	--	16973920 16673373 16876704 17284842
L-Methionine	(S)-2-amino-4-(methylthio)butanoic acid (see all 6)	63-68-3	enzyme	inhibitor	6127334 4144717 4308004
Ceftriaxone	Cefatriaxone (see all 4)	73384-59-5	enzyme	inducer	10696140 20423712
Diazoxide	--	364-98-7	enzyme	inhibitor	7926271
Dihydroergotoxine	--	11032-41-0	enzyme	inducer	6117619
Pegvisomant	GH (see all 6)	218620-50-9	enzyme	inhibitor	1970314
Picrotoxin	--	124-87-8	enzyme	inhibitor	840320

10/95 Novoseek chemical compound relationships for GLUL gene (see all 95) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
glutamine	96.3	1584	10681395 (8), 10943675 (8), 11589877 (8), 9288153 (8) (see all 99)
methionine sulfoximine	93.5	62	14714472 (2), 20060132 (2), 12390519 (1), 12840174 (1) (see all 38)
glutamate	81.3	432	19728998 (7), 20064572 (6), 20373878 (5), 12390519 (4) (see all 99)
ammonium	73.2	84	8563633 (5), 16173463 (3), 19464754 (3), 14757761 (3) (see all 33)
gamma-glutamyl phosphate	71	5	8563633 (3), 10664863 (1)
phosphinothricin	67	24	17888468 (6), 16510221 (3), 16504520 (1), 12723887 (1) (see all 7)
alpha-ketoglutarate	64.3	5	18421771 (1), 8971000 (1), 1360177 (1), 17477312 (1)
2',3'-cyclic nucleotide	58.3	2	1979258 (1), 10366697 (1)
carbamoyl phosphate	54.2	13	1976588 (5), 17518723 (1), 1687030 (1), 8587121 (1) (see all 5)
nitrate	52.3	38	7534371 (2), 9244251 (1), 18419739 (1), 1967601 (1) (see all 23)

Search CenterWatch for drugs/clinical trials and news about GLUL / GLNA

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for GLUL gene (3 alternative transcripts):

NM_001033044.2 NM_001033056.2 NM_002065.5

Unigene Cluster for GLUL:

Glutamate-ammonia ligase

Hs.518525 [show with all ESTs]

Unigene Representative Sequence: NM_002065

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000331872(uc010pnt.2 uc001gpd.2) ENST00000491322 ENST00000339526

ENST00000463851 ENST00000461447 ENST00000484996 ENST00000489818 ENST00000475808

ENST00000480604 ENST00000462444 ENST00000311223(uc001gpb.2 uc001gpc.2)

ENST00000417584(uc001gpa.2)

miRNA Products:		OriGene 3'-UTR Clone (see all 3): GLUL Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GLUL
		8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate GLUL (see all 22):
		hsa-miR-140-5p hsa-miR-582-3p hsa-miR-3607-3p hsa-miR-4286 hsa-miR-1285 hsa-miR-340 hsa-miR-3170 hsa-miR-497*

		SwitchGear 3'UTR luciferase reporter plasmid: GLUL 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GLUL (see all 7) OriGene shRNA RFP: GLUL OriGene siRNA: GLUL
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GLUL

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GLUL (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GLUL (see all 5) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): GLUL (NM_002065)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for GLUL
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GLUL

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GLUL Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat GLUL
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GLUL
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GLUL

Additional cDNA sequence:

AK122784.1 AK301600.1 AY486122.1 AY513283.1 AY947343.1 BC010037.2 BC011700.2 BC011852.2

BC018992.1 BC031964.1 BC051726.1 BC127883.1 BX537384.1 S70290.1 X59834.1 Y00387.2

24/60 DOTS entries (see all 60):

DT.97789039 DT.95297120 DT.91909750 DT.95176992 DT.100687848 DT.91707765 DT.100687841 DT.100687844

DT.92475794 DT.95075484 DT.100687842 DT.102837867 DT.85104875 DT.91813488 DT.100687839 DT.91875449

DT.95075478 DT.100873067 DT.75153967 DT.121426398 DT.100040371 DT.100687840 DT.100687850 DT.100875350

24/1446 AceView cDNA sequences (see all 1446):

BQ002061 BQ576351 BU684513 AI719547 CN480796 CR607019 AI459987 AU156570

BM802794 BU726821 AI688954 AA779772 AA418870 BM704235 CD370427 N50404

AW088371 BM463504 CF457060 AI185982 AW029225 AI304745 AW340277 CD722164

GeneLoc Exon Structure

5/20 Alternative Splicing Database (ASD) splice patterns (SP) for GLUL (see all 20) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4a	·	4b	^	5	^	6a	·	6b	^	7	^	8a	·	8b	·	8c	·	8d	^	9	^	10a	·	10b	^	11a	·	11b	^	12a	·	12b	·	12c	^	13a	·	13b	·
SP1:									-		-		-		-				-		-		-										-				-		-								-		-
SP2:									-		-		-		-		-		-		-		-										-				-		-								-		-
SP3:																			-		-		-										-				-		-								-		-
SP4:													-		-		-		-		-		-										-				-		-								-		-
SP5:									-		-		-		-		-		-		-		-						-		-		-		-		-		-		-		-		-		-		-		-

ExUns:	13c	·	13d	·	13e	·	13f	^	14a	·	14b	·	14c	^	15a	·	15b	·	15c	·	15d
SP1:					-		-
SP2:					-		-
SP3:					-		-
SP4:					-		-
SP5:					-		-

ECgene alternative splicing isoforms for GLUL

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

GLUL expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TACAGTATGT

About this image

GLUL expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Inner Nuclear Layer

Mature Muller Glia Cells

Selective marker (cell-identifying gene)

Muller Glia, Retina

Liver

Liver Lobule

Perivenous Hepatocytes

Liver

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Retina-like cells (Generation of retina...)

See GLUL Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GLUL

SOURCE GeneReport for Unigene cluster: Hs.518525

SABiosciences Expression via Pathway-Focused PCR Arrays including GLUL:

Nephrotoxicity in human mouse rat

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for GLUL gene from 10/38 species (see all 38) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Glul^{1 , 5}	glutamate-ammonia ligase (glutamine synthetase)^{1, 5}	89.45(n)¹ 94.64(a)¹		1 (65.43 cM)⁵ 14645¹ NM_008131.3¹ NP_032157.2¹ 153899944⁵
chicken (Gallus gallus)	Aves	GLUL¹	glutamate-ammonia ligase	78.91(n) 88.74(a)		396489 NM_205493.1 NP_990824.1
lizard (Anolis carolinensis)	Reptilia	GLUL⁶	--	89(a)	1 ↔ 1	GL343712.1(211351-222114)
African clawed frog (Xenopus laevis)	Amphibia	glul-prov²	glutamate-ammonia ligase (glutamine synthase)	76.31(n)		BC054153.1
zebrafish (Danio rerio)	Actinopterygii	AY423006.1²	--	83.48(n)		AY423006.1
fruit fly (Drosophila melanogaster)	Insecta	Gs2^{1 , 3}	glutamate-ammonia ligase³ Glutamine synthetase 2¹	60(a) (best of 2)³ 64.44(n)¹ 66.11(a)¹		10B11³ 32087¹ NM_167284.1¹ NP_727525.1¹
worm (Caenorhabditis elegans)	Secernentea	Y105C5B.28³ gln-3¹	Protein GLN-3¹	64(a) (best of 5)³ 60.98(n)¹ 64.77(a)¹		IV(16168058-16170839)³ 178452¹ NM_001047544.3¹ NP_001041009.1¹
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	GLN1(YPR035W)⁴ GLN1¹	Glutamine synthetase (GS), synthesizes glutamine from more⁴ Gln1p¹	57.18(n)¹ 57.18(a)¹		16(642208-643320)⁴ 856147^{1, 4} NP_015360.2¹ NP_015360.1⁴
thale cress (Arabidopsis thaliana)	eudicotyledons	GLN1.3¹	glutamine synthetase cytosolic isozyme 1-3	57.96(n) 57.36(a)		821050 NM_112663.2 NP_188409.1
rice (Oryza sativa)	Liliopsida	Os.7879²	Oryza sativa shoot GS2 mRNA for chloroplastic glutamine more	73.63(n)		AK099252.1

ENSEMBL Gene Tree for GLUL (if available)
TreeFam Gene Tree for GLUL (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for GLUL gene

3 SIMAP similar genes for GLUL using alignment to 2 protein entries: GLNA_HUMAN (see all proteins):

PIG59 DKFZp434M0813 PIG43

GLUL for paralogs About GeneDecksing

5/6 Pseudogenes.org Pseudogenes for GLUL (see all 6)
PGOHUM00000242168 PGOHUM00000242513 PGOHUM00000239935 PGOHUM00000240465 PGOHUM00000235814

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs77070600^1,2		--	153587376(+)	`ACAGGA/CATAAA`	3	--	ut3¹		0	--	--	--	--
rs16858921^1,2	C,F,H,	--	153587849(+)	`TCGGTC/ACACTG`	3	--	ut3¹ ese³		16		NA NS EA WA CSA	1458
rs79056692^1,2	F,	--	153587912(+)	`GCCAGC/TCTTGG`	3	--	ut3¹		1		NA	120
rs1058806^1,2	C,F,	--	153588465(-)	`AACTTC/TTAATT`	3	--	ut3¹ ese³		2		MN WA	302
rs1058788^1,2	C,A	--	153588483(-)	`GTTTTC/TTTTTG`	3	--	ut3¹		2		MN NA	186
rs115448180^1,2	C,F,	--	153588512(+)	`GCCAAC/TACAAG`	3	--	ut3¹		1		WA	118
rs78220577^1,2	C,F,	--	153588536(+)	`TAGATG/TANNNN`	3	--	ut3¹		1		NA	120
rs7543200^1,2	C,A,	--	153588910(+)	`GTGTGT/CCTTTT`	3	--	ut3¹		2		CSA WA	120
rs8762^1,2	C,F,O,	--	153588954(-)	`ACAACA/GCGTTA`	3	--	ut3¹ ese³		4		MN WA CSA	306
rs12082312^1,2		--	153589048(+)	`CACCAC/TCTAAG`	3	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for GLUL (182350839 - 182361341 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for GLUL
1 CNV: 65380
Human Gene Mutation Database (HGMD): GLUL

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

GLUL for disorders           About GeneDecksing

OMIM gene information: 138290
OMIM disorders: 610015
UniProtKB/Swiss-Prot: GLNA_HUMAN, P15104

Defects in GLUL are the cause of congenital systemic glutamine deficiency (CSGD) [MIM:610015]. CSGD is a rare

developmental disorder with severe brain malformation resulting in multi-organ failure and neonatal death. Glutamine

is largely absent from affected patients serum, urine and cerebrospinal fluid

20/73 diseases for GLUL (see all 73): About MalaCards

glutamine deficiency, congenital glutathione synthetase deficiency hyperinsulinism-hyperammonemia syndrome familial adenomatous polyposis

creatine phosphokinase non-small cell lung carcinoma amyotrophic lateral sclerosis temporal lobe epilepsy

retinal detachment reye syndrome brain edema lateral sclerosis

proliferative vitreoretinopathy porphyria herpes simplex vitreoretinopathy

febrile seizures paranoid schizophrenia toxic encephalopathy hepatic encephalopathy

10/56 Novoseek disease relationships for GLUL gene (see all 56) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
hyperammonemia	67.3	8	12020613 (2), 15841446 (1), 1352200 (1), 1677585 (1)
hepatic encephalopathy	43.2	2	10564534 (1), 12020613 (1)
hepatocellular carcinoma	39.5	13	1346587 (3), 18282277 (2), 10952242 (2), 20525558 (1) (see all 6)
brain diseases	32.4	3	18062818 (1), 9166739 (1), 11004532 (1)
gliosis	30.3	2	8570019 (1), 19183851 (1)
liver failure	29.5	5	10564534 (1), 17299991 (1), 11549067 (1), 16382338 (1)
alzheimers disease	27.9	26	10733015 (5), 10520940 (2), 9166739 (2), 11746426 (2) (see all 12)
neurodegeneration	27.8	3	20107048 (2), 14681883 (1)
epilepsy temporal lobe	26.3	6	16095760 (1), 14723991 (1), 19170755 (1), 18226171 (1) (see all 5)
reye syndrome	25.9	1	10199339 (1)

Genetic Association Database (GAD): GLUL
Human Genome Epidemiology (HuGE) Navigator: GLUL (3 documents)

Export disorders for GLUL gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for GLUL gene, integrated from 9 sources (see all 546):
(articles sorted by number of sources associating them with GLUL)

Utopia: connect your pdf to the dynamic
world of online information

cDNA sequence of the long mRNA for human glutamine synthase. (PubMed id 1681907)^{1, 2, 3} van den Hoff M.J.B....Lamers W.H. (1991)
Sequence of a human glutamine synthetase cDNA. (PubMed id 2888076)^{1, 2, 3} Gibbs C.S.... Wilson R.H. (1987)
Wnt and steroid pathways control glutamate signalling by regulating glutamine synthetase activity in osteoblastic cells. (PubMed id 18555765)^{1, 2, 9} Olkku A. and Mahonen A. (2008)
Glutamine synthetase is essential for proliferation of fetal skin fibroblasts. (PubMed id 18662667)^{1, 2, 9} Vermeulen T....Haberle J. (2008)
Overexpression of glutamine synthetase in human primary liver cancer. (PubMed id 7909780)^{1, 2, 9} Christa L....Lasserre C. (1994)
An association study between polymorphisms in five genes in glutamate and GABA pathway and paranoid schizophrenia. (PubMed id 15642443)^{1, 4, 9} Zhang B....Shen Y. (2005)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
Congenital glutamine deficiency with glutamine synthetase mutations. (PubMed id 16267323)^{1, 2} Haeberle J.... Koch H.G. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Glutamine synthetase in cerebrospinal fluid, serum, and brain: a diagnostic marker for Alzheimer disease? (PubMed id 10520940)^{1, 9} Tumani H....Bruck W. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 2752	HGNC: 4341	AceView: GLUL	Ensembl:ENSG00000135821	euGenes: HUgn2752
ECgene: GLUL	Kegg: 2752	H-InvDB: GLUL

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for GLUL	Pharmacogenomics, SNPs, Pathways
Wikipedia	http://en.wikipedia.org/wiki/Glutamine_synthetase

Intellectual Property for GLUL gene
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Patent Information for GLUL gene:
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GeneCards and IP:
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GLUL Gene

glutamate-ammonia ligase

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GLUL Gene

glutamate-ammonia ligase

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