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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

GLUD2 Gene

protein-coding GIFtS: 61
GCID: GC0XP120181

glutamate dehydrogenase 2

(Previous name: glutamate dehydrogenase pseudogene 1 )
(Previous symbol: GLUDP1)

Explore 16 diseases affiliated with
GLUD2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Glutamate Dehydrogenase 2¹ ²		EC 1.4.1.3³ ⁸
GLUDP1¹ ² ³		GDH2²
Glutamate Dehydrogenase Pseudogene 1¹ ²		Glutamate Dehydrogenase 2, Mitochondrial²
GDH 2² ³		EC 1.4.1⁸

External Ids:	HGNC: 4336¹	Entrez Gene: 2747²	Ensembl: ENSG00000182890⁷	OMIM: 300144⁵	UniProtKB: P49448³

Export aliases for GLUD2 gene to outside databases

Previous GC identifers: GC0XP114899 GC0XU900011 GC0XP9V0098 GC0XP119906 GC0XP120009 GC0XP109559

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GLUD2:

The protein encoded by this gene is localized to the mitochondrion and acts as a homohexamer to recycle glutamate

during neurotransmission. The encoded enzyme catalyzes the reversible oxidative deamination of glutamate to

alpha-ketoglutarate. This gene is intronless.(provided by RefSeq, Jan 2010)

UniProtKB/Swiss-Prot: DHE4_HUMAN, P49448

Function: Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission

Gene Wiki entry for GLUD2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000023.10 NC_018934.1 NT_011786.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the GLUD2 gene promoter:
Elk-1 p53 LUN-1 POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) Nkx2-5 POU3F2 C/EBPalpha Evi-1 Chx10
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GLUD2 promoter sequence

Search SABiosciences Chromatin IP Primers for GLUD2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GLUD2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq24-q25 Ensembl cytogenetic band: Xq24 HGNC cytogenetic band: Xq24-q25

GLUD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GLUD2 gene location

GeneLoc information about chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XP120181: view genomic region (about GC identifiers)

Start:	120,181,462 bp from pter	End:	120,183,796 bp from pter
Size:	2,335 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DHE4_HUMAN, P49448 (See protein sequence)

Recommended Name: Glutamate dehydrogenase 2, mitochondrial precursor

Size: 558 amino acids; 61434 Da

Subunit: Homohexamer (By similarity)

Subcellular location: Mitochondrion matrix

Secondary accessions: B2R8G0 Q9UDQ4

Explore the universe of human proteins at neXtProt for GLUD2: NX_P49448

Post-translational modifications:

Stoichiometry shows that ADP-ribosylation occurs in one subunit per catalytically active homohexamer¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P49448

4/27 DME Specific Peptides for GLUD2 (P49448) (see all 27)

QGFGNVG

ARRHYSE

ACVTGKP

DVPAPDM

GLUD2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_036216.2

ENSEMBL proteins:

ENSP00000327589

Human Recombinant Protein Products:

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	Uscn Proteins for GLUD2

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	NOT cytoplasm	IDA	18688271
GO:0005739	mitochondrion	IDA	--

GLUD2 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for GLUD2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

GLUD2 for domains About GeneDecksing

4 InterPro domains/families:

IPR006096 Glu/Leu/Phe/Val_DH_C

IPR006095 Glu/Leu/Phe/Val_DH

IPR016040 NAD(P)-bd_dom

IPR006097 Glu/Leu/Phe/Val_DH_dimer_dom

Graphical View of Domain Structure for InterPro Entry P49448

ProtoNet protein and cluster: P49448

1 Blocks protein family: IPB006095 Glu/Leu/Phe/Val dehydrogenase

UniProtKB/Swiss-Prot: DHE4_HUMAN, P49448

Similarity: Belongs to the Glu/Leu/Phe/Val dehydrogenases family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: DHE4_HUMAN, P49448

Function: Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission

Catalytic activity: L-glutamate + H(2)O + NAD(P)(+) = 2-oxoglutarate + NH(3) + NAD(P)H

Genatlas biochemistry entry for GLUD2:

glutamate dehydrogenase 2,expressed in retina,testis,brain

Enzyme Numbers (IUBMB): EC 1.4.1.3¹ ² EC 1.4.1²

miRNA Products:		OriGene 3'-UTR Clone: GLUD2 Browse MicroRNA Expression Plasmids
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		1 QIAGEN miScript miRNA Assays for microRNA that regulate GLUD2:
		hsa-miR-580
		SwitchGear 3'UTR luciferase reporter plasmid: GLUD2 3' UTR sequence

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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for GLUD2

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GLUD2

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004352	glutamate dehydrogenase (NAD+) activity	IDA	8207021
GO:0004353	glutamate dehydrogenase [NAD(P)+] activity	IDA	11032875
GO:0005525	GTP binding	IDA	11032875
GO:0043531	ADP binding	IDA	12742085
GO:0070728	leucine binding	IDA	12742085

GLUD2 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

glutamate degradation X

	glutamate biosynthesis II	1.00			arginine biosynthesis IV	0.33
	glutamate degradation X	1.00

Proximal tubule bicarbonate reclamation

Proximal tubule bicarbonate reclamation

1.00

Arginine and proline metabolism

Arginine and proline metabolism

1.00

Alanine, aspartate and glutamate metabolism

Alanine, aspartate and glutamate metabolism

1.00

Reversible Hydration of Carbon Dioxide

Nitrogen metabolism

0.52

Pathway sources
See GeneCards unified pathways
Show all pathways

3 BioSystems Pathways for GLUD2

	arginine biosynthesis IV
	glutamate degradation X
	glutamate biosynthesis II

5/6 Kegg Pathways (Kegg details for GLUD2) (see all 6):

	Alanine, aspartate and glutamate metabolism
	Arginine and proline metabolism
	D-Glutamine and D-glutamate metabolism
	Nitrogen metabolism
	Metabolic pathways

GLUD2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for GLUD2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/59 Interacting proteins for GLUD2 (P49448^{2, 3} ENSP00000327589⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 59)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TOM1L1	O75674²^,³	MINT-63778 I2D: score=4
TRMT10C	Q7L0Y3³, ENSP00000312356⁴	I2D: score=1 STRING: ENSP00000312356
MYC	P01106³	I2D: score=1
ALDH18A1	ENSP00000360268⁴	STRING: ENSP00000360268
ALDH4A1	ENSP00000290597⁴	STRING: ENSP00000290597

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006536	glutamate metabolic process	IDA	8207021
GO:0006537	glutamate biosynthetic process	IDA	11032875
GO:0006538	glutamate catabolic process	IDA	11032875
GO:0055114	oxidation-reduction process	IDA	8207021

GLUD2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

GLUD2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for GLUD2

9 HMDB Compounds for GLUD2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Ammonia	NH3 (see all 31)	7664-41-7	--
Famotidine	Amfamox (see all 83)	76824-35-6	--
L-Glutamic acid	(2S)-2-Aminopentanedioate (see all 49)	56-86-0	--
NAD	3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)	53-84-9	--
NADH	1,4-Dihydronicotinamide adenine dinucleotide (see all 17)	58-68-4	--
NADP	Adenine-nicotinamide dinucleotide phosphate (see all 18)	53-59-8	--
NADPH	2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)	53-57-6	--
Oxoglutaric acid	2-Ketoglutarate (see all 9)	328-50-7	--
Water	Dihydrogen oxide (see all 2)	7732-18-5	--

3 DrugBank Compounds for GLUD2 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
L-Glutamic Acid	(2S)-2-Aminopentanedioic acid (see all 15)	56-86-0	target	--	17139284 17016423
NADH	beta-DPNH (see all 18)	606-68-8	target	--	17139284 17016423
Nicotinamide-Adenine-Dinucleotide	--	53-84-9	target	--	10592235

8 Novoseek chemical compound relationships for GLUD2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
glutamate	78.6	53	17500210 (3), 8738168 (2), 1686899 (2), 11032875 (2) (see all 37)
gtp	53.3	2	12742085 (2)
adp	51.6	1	12742085 (1)
leucine	49.8	1	12742085 (1)
alpha-ketoglutarate	46.2	1	16120687 (1)
toxin a	40.1	9	10947228 (3), 16124706 (3)
aspartate	25.7	3	15092215 (1), 1686899 (1), 9127191 (1)
alanine	18.9	1	15092215 (1)

Search CenterWatch for drugs/clinical trials and news about GLUD2 / DHE4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for GLUD2 gene:

NM_012084.3

Unigene Cluster for GLUD2:

Glutamate dehydrogenase 2

Hs.368538 [show with all ESTs]

Unigene Representative Sequence: BC050732

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000328078(uc004eto.3)

miRNA Products:		OriGene 3'-UTR Clone: GLUD2 Browse OriGene MicroRNA Expression Plasmids
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		1 QIAGEN miScript miRNA Assays for microRNA that regulate GLUD2:
		hsa-miR-580
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Additional cDNA sequence:

AK313356.1 BC005111.1 BC050732.2

9 DOTS entries:

DT.102840028 DT.100818693 DT.454907 DT.101962257 DT.95355575 DT.91769355 DT.100760791 DT.100818695

DT.99982198

23 AceView cDNA sequences:

BC050732 BQ227063 BC005111 BU190860 NM_012084 BG122137 BU166908 AU129271

BP431298 AA353744 BG104158 BQ681175 BQ343861 CD620134 M78112 AW818494

BQ312551 AI003870 BI597888 AW901922 BF950913 W05028 BF125637

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

GLUD2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGCTGTAAT

About this image

GLUD2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Primitive gut tube-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See GLUD2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GLUD2

SOURCE GeneReport for Unigene cluster: Hs.368538

UniProtKB/Swiss-Prot: DHE4_HUMAN, P49448

Tissue specificity: Expressed in retina, testis and, at a lower level, brain

SABiosciences Custom PCR Arrays for GLUD2

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GLUD2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GLUD2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for GLUD2 gene from 8/28 species (see all 28) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	F1P3F9_CHICK⁶	Uncharacterized protein	93(a)	1 → many	6(3646956-3665151)
lizard (Anolis carolinensis)	Reptilia	-- --	--	85(a) 74(a)	1 ↔ many possible ortholog	GL343199.1(4105571-4144227) GL343526.1(441039-463241)
zebrafish (Danio rerio)	Actinopterygii	glud1a¹	glutamate dehydrogenase 1a	74.51(n) 83.09(a)		317737 NM_212576.1 NP_997741.1
fruit fly (Drosophila melanogaster)	Insecta	Gdh³	glutamate dehydrogenase (NAD(P)+)	66(a) (best of 2)		--
worm (Caenorhabditis elegans)	Secernentea	ZK829.4³	glutamate dehydrogenase	62(a)		IV(11953424-11955386) --
thale cress (Arabidopsis thaliana)	eudicotyledons	GDH1⁶ GDH2⁶ (see all 4)	glutamate dehydrogenase 2 (see all 4)	39(a) 39(a) (see all 4)	possible ortholog possible ortholog (see all 4)	5(6006039-6008472) 5(2355937-2358194)
rice (Oryza sativa)	Liliopsida	-- -- (see all 4)	glutamate dehydrogenase protein, putative, express... glutamate dehydrogenase protein, putative, express... (see all 4)	38(a) 38(a) (see all 4)	possible ortholog possible ortholog (see all 4)	4(27048230-27052974) 2(26234257-26237114)
E. coli (Escherichia coli)	Gamma proteobacteria	gdhA⁶	glutamate dehydrogenase, NADP-specific	25(a)	possible ortholog	Chromosome(1840395-1841738)

ENSEMBL Gene Tree for GLUD2 (if available)
TreeFam Gene Tree for GLUD2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for GLUD2 gene

GLUD1²

1 SIMAP similar gene for GLUD2 using alignment to 2 protein entries: DHE4_HUMAN (see all proteins):

GLUD1

GLUD2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr X pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs9780362^1,2	C,F,H,	--	120179480(+)	`gctaaA/Ttgatg`	1	--	us2k¹		7		NS EA NA	425
rs148564445^1,2		--	120179732(+)	`TTGGGA/CTATTC`	1	--	us2k¹		0	--	--	--	--
rs147746829^1,2		--	120179774(+)	`GGTACC/TACGCT`	1	--	us2k¹		0	--	--	--	--
rs183929589^1,2		--	120179777(+)	`ACCACA/GCTATT`	1	--	us2k¹		0	--	--	--	--
rs187919600^1,2		--	120180049(+)	`ACTTAC/TGCCTC`	1	--	us2k¹		0	--	--	--	--
rs5909779^1,2	C,F,H,	--	120180324(+)	`TTTGGA/CGTTTG`	1	--	us2k¹ tfbs³		22	--	NS EA NA WA CSA	2406
rs151257353^1,2		--	120180617(+)	`ATGACA/TGCCGA`	1	--	us2k¹		0	--	--	--	--
rs5956265^1,2	F,	--	120181352(+)	`CCTGGG/TTGGCG`	1	--	us2k¹ tfbs³		2		NA	4
rs5956266^1,2	C,F,	--	120181353(+)	`CTGGTC/TGGCGC`	1	--	us2k¹ tfbs³		2		NA	4
rs112360628^1,2	C,	--	120181366(+)	`TGCCCG/CCAAAG`	1	--	us2k¹		1		NA	1

HapMap Linkage Disequilibrium report for GLUD2 (120181462 - 120183796 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for GLUD2: --
Human Gene Mutation Database (HGMD): GLUD2

Locus Specific Mutation Databases (LSDB): GLUD2

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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GLUD2 for disorders           About GeneDecksing

OMIM gene information: 300144    OMIM disorders: --

16 diseases for GLUD2:    About MalaCards

machado-joseph disease clostridium difficile hyperinsulinemic hypoglycemia amyotrophic lateral sclerosis

lateral sclerosis rett syndrome hypoglycemia gout

parkinson's disease alzheimer's disease ataxia pneumonia

schizophrenia pancreatitis malaria neuronitis

Human Genome Epidemiology (HuGE) Navigator: GLUD2 (2 documents)

Export disorders for GLUD2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for GLUD2 gene, integrated from 9 sources (see all 84):
(articles sorted by number of sources associating them with GLUD2)

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Novel human glutamate dehydrogenase expressed in neural and testicular tissues and encoded by an X-linked intronless gene. (PubMed id 8207021)^{1, 2, 3, 9} Shashidharan P.... Plaitakis A. (1994)
Nerve tissue-specific human glutamate dehydrogenase that is thermolabile and highly regulated by ADP. (PubMed id 9109504)^{1, 3, 9} Shashidharan P....Plaitakis A. (1997)
Alpha helical structures in the leader sequence of human GLUD2 glutamate dehydrogenase responsible for mitochondrial import. (PubMed id 22709669)^{1, 2} Kotzamani D. and Plaitakis A. (2012)
The DNA sequence of the human X chromosome. (PubMed id 15772651)^{1, 2} Ross M.T.... Bentley D.R. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Mitochondrial targeting adaptation of the hominoid-specific glutamate dehydrogenase driven by positive Darwinian selection. (PubMed id 18688271)^{1, 9} Rosso L....Kaessmann H. (2008)
Properties and molecular evolution of human GLUD2 (neural and testicular tissue-specific) glutamate dehydrogenase. (PubMed id 17924438)^{1, 9} Kanavouras K....Plaitakis A. (2007)
Birth and adaptive evolution of a hominoid gene that supports high neurotransmitter flux. (PubMed id 15378063)^{1, 9} Burki F. and Kaessmann H. (2004)
Diversity of glutamate dehydrogenase in human brain. (PubMed id 11999891)^{1, 9} Burbaeva G.S.h....Boksha I.S. (2002)
Study of structure-function relationships in human glutamate dehydrogenases reveals novel molecular mechanisms for the regulation of the nerve tissue-specific (GLUD2) isoenzyme. (PubMed id 12742085)^{1, 9} Plaitakis A....Zaganas I. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 2747	HGNC: 4336	AceView: GLUD2	Ensembl:ENSG00000182890	euGenes: HUgn2747
ECgene: GLUD2	Kegg: 2747	H-InvDB: GLUD2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for GLUD2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for GLUD2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for GLUD2 gene:
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