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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GLUD2 Gene

protein-coding   GIFtS: 63
GCID: GC0XP120181

Glutamate Dehydrogenase 2

(Previous name: glutamate dehydrogenase pseudogene 1)
(Previous symbol: GLUDP1)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Glutamate Dehydrogenase 21 2     EC 1.4.1.33 8
GLUDP11 2 3     GDH22
Glutamate Dehydrogenase Pseudogene 11 2     Glutamate Dehydrogenase 2, Mitochondrial2
GDH 22 3     EC 1.4.18

External Ids:    HGNC: 43361   Entrez Gene: 27472   Ensembl: ENSG000001828907   OMIM: 3001445   UniProtKB: P494483   

Export aliases for GLUD2 gene to outside databases

Previous GC identifers: GC0XP114899 GC0XU900011 GC0XP9V0098 GC0XP119906 GC0XP120009 GC0XP109559


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GLUD2 Gene:
The protein encoded by this gene is localized to the mitochondrion and acts as a homohexamer to recycle glutamate
during neurotransmission. The encoded enzyme catalyzes the reversible oxidative deamination of glutamate to
alpha-ketoglutarate. This gene is intronless.(provided by RefSeq, Jan 2010)

GeneCards Summary for GLUD2 Gene: 
GLUD2 (glutamate dehydrogenase 2) is a protein-coding gene. Diseases associated with GLUD2 include clostridium difficile, and gout, and among its related super-pathways are arginine biosynthesis IV and Reversible Hydration of Carbon Dioxide. GO annotations related to this gene include leucine binding and GTP binding. An important paralog of this gene is GLUD1.

UniProtKB/Swiss-Prot: DHE4_HUMAN, P49448
Function: Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission

Gene Wiki entry for GLUD2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.2  NT_011786.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GLUD2 gene promoter:
         Elk-1   p53   LUN-1   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   Nkx2-5   POU3F2   C/EBPalpha   Evi-1   Chx10   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGLUD2 promoter sequence
   Search SABiosciences Chromatin IP Primers for GLUD2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GLUD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq24-q25   Ensembl cytogenetic band:  Xq24   HGNC cytogenetic band: Xq24-q25

GLUD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GLUD2 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP120181:  view genomic region     (about GC identifiers)

Start:
120,181,462 bp from pter      End:
120,183,796 bp from pter
Size:
2,335 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DHE4_HUMAN, P49448 (See protein sequence)
Recommended Name: Glutamate dehydrogenase 2, mitochondrial precursor  
Size: 558 amino acids; 61434 Da
Subunit: Homohexamer (By similarity)
Subcellular location: Mitochondrion matrix
Secondary accessions: B2R8G0 Q9UDQ4

Explore the universe of human proteins at neXtProt for GLUD2: NX_P49448

Explore proteomics data for GLUD2 at MOPED 

Post-translational modifications:

  • UniProtKB: Stoichiometry shows that ADP-ribosylation occurs in one subunit per catalytically active homohexamer
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P49448

  • 4/27 DME Specific Peptides for GLUD2 (P49448) (see all 27)
     QGFGNVG  ARRHYSE  ACVTGKP  DVPAPDM 

    GLUD2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GLUD2 Protein Expression
    REFSEQ proteins: NP_036216.2  
    ENSEMBL proteins: 
     ENSP00000327589  

    Human Recombinant Protein Products for GLUD2: 
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    Novus Biologicals GLUD2 Proteins
    Novus Biologicals GLUD2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for GLUD2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737NOT cytoplasm IDA18688271
    GO:0005739mitochondrion IDA--

    GLUD2 for ontologies           About GeneDecksing



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    Assay Products for GLUD2: 
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    Cloud-Clone Corp. ELISAs for GLUD2 
    Cloud-Clone Corp. CLIAs for GLUD2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR006096 Glu/Leu/Phe/Val_DH_C
     IPR006095 Glu/Leu/Phe/Val_DH
     IPR016040 NAD(P)-bd_dom
     IPR006097 Glu/Leu/Phe/Val_DH_dimer_dom

    Graphical View of Domain Structure for InterPro Entry P49448

    ProtoNet protein and cluster: P49448

    1 Blocks protein domain: IPB006095 Glu/Leu/Phe/Val dehydrogenase

    UniProtKB/Swiss-Prot: DHE4_HUMAN, P49448
    Similarity: Belongs to the Glu/Leu/Phe/Val dehydrogenases family


    GLUD2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DHE4_HUMAN, P49448
    Function: Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission
    Catalytic activity: L-glutamate + H(2)O + NAD(P)(+) = 2-oxoglutarate + NH(3) + NAD(P)H

         Genatlas biochemistry entry for GLUD2:
    glutamate dehydrogenase 2,expressed in retina,testis,brain

         Enzyme Numbers (IUBMB): EC 1.4.1.31 2 EC 1.4.12

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004352glutamate dehydrogenase (NAD+) activity IDA15578726
    GO:0004353glutamate dehydrogenase [NAD(P)+] activity IDA11032875
    GO:0005525GTP binding IDA11032875
    GO:0016491oxidoreductase activity ----
    GO:0043531ADP binding IDA12742085
         
    GLUD2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for GLUD2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GLUD2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GLUD2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GLUD2 

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate GLUD2:
    hsa-miR-580
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    Inhib. RNA
    Products:
        
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    Clone
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GLUD2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GLUD2 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1glutamate degradation X
    arginine biosynthesis IV0.38
    glutamate biosynthesis II0.33
    glutamate degradation X0.33
    2Reversible Hydration of Carbon Dioxide
    Nitrogen metabolism0.67
    3glutamine degradation I
    D-Glutamine and D-glutamate metabolism0.40
    4Metabolism
    Metabolic pathways0.40
    5Arginine and proline metabolism
    Arginine and proline metabolism0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for GLUD2
        arginine biosynthesis IV
    glutamate degradation X
    glutamate biosynthesis II


    5/6         Kegg Pathways  (Kegg details for GLUD2) (see all 6):
        Alanine, aspartate and glutamate metabolism
    Arginine and proline metabolism
    D-Glutamine and D-glutamate metabolism
    Nitrogen metabolism
    Metabolic pathways


    GLUD2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GLUD2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/59 Interacting proteins for GLUD2 (P494482, 3 ENSP000003275894) via UniProtKB, MINT, STRING, and/or I2D (see all 59)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TOM1L1O756742, 3MINT-63778 I2D: score=4 
    TRMT10CQ7L0Y33, ENSP000003123564I2D: score=1 STRING: ENSP00000312356
    MYCP011063I2D: score=1 
    ALDH18A1ENSP000003602684STRING: ENSP00000360268
    ALDH4A1ENSP000002905974STRING: ENSP00000290597
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006520cellular amino acid metabolic process ----
    GO:0006536glutamate metabolic process IDA8207021
    GO:0006537glutamate biosynthetic process IDA11032875
    GO:0006538glutamate catabolic process IDA11032875
    GO:0055114oxidation-reduction process IDA8207021

    GLUD2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GLUD2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GLUD2 (DHE4)

    9 HMDB Compounds for GLUD2    About this table
    CompoundSynonyms CAS #PubMed Ids
    AmmoniaNH3 (see all 31)7664-41-7--
    FamotidineAmfamox (see all 83)76824-35-6--
    L-Glutamic acid(2S)-2-Aminopentanedioate (see all 49)56-86-0--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--
    Oxoglutaric acid2-Ketoglutarate (see all 9)328-50-7--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    3 DrugBank Compounds for GLUD2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Glutamic Acid(2S)-2-Aminopentanedioic acid (see all 15)56-86-0target--17139284 17016423
    NADHbeta-DPNH (see all 18)606-68-8target--17139284 17016423
    Nicotinamide-Adenine-Dinucleotide-- 53-84-9target--10592235

    8 Novoseek inferred chemical compound relationships for GLUD2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glutamate 78.6 53 17500210 (3), 8738168 (2), 1686899 (2), 11032875 (2) (see all 37)
    gtp 53.3 2 12742085 (2)
    adp 51.6 1 12742085 (1)
    leucine 49.8 1 12742085 (1)
    alpha-ketoglutarate 46.2 1 16120687 (1)
    toxin a 40.1 9 10947228 (3), 16124706 (3)
    aspartate 25.7 3 15092215 (1), 1686899 (1), 9127191 (1)
    alanine 18.9 1 15092215 (1)

    Search CenterWatch for drugs/clinical trials and news about GLUD2 / DHE4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GLUD2 gene: 
    NM_012084.3  

    Unigene Cluster for GLUD2:

    Glutamate dehydrogenase 2
    Hs.368538  [show with all ESTs]
    Unigene Representative Sequence: BC050732
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000328078(uc004eto.3)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GLUD2
    1 QIAGEN miScript miRNA Assays for microRNA that regulate GLUD2:
    hsa-miR-580
    SwitchGear 3'UTR luciferase reporter plasmidGLUD2 3' UTR sequence
    Inhib. RNA
    Products:
         
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GLUD2

    Additional mRNA sequence: 

    AK313356.1 BC005111.1 BC050732.2 

    9 DOTS entries:

    DT.102840028  DT.100818693  DT.454907  DT.101962257  DT.95355575  DT.91769355  DT.100760791  DT.100818695 
    DT.99982198 

    23 AceView cDNA sequences:

    BQ227063 BC050732 BU190860 BC005111 NM_012084 BU166908 BG122137 AU129271 
    BP431298 AA353744 BG104158 AW818494 CD620134 BQ343861 BQ681175 M78112 
    BQ312551 AI003870 BI597888 AW901922 BF950913 W05028 BF125637 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GLUD2 expression in normal human tissues (normalized intensities)      GLUD2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGCTGTAAT
    GLUD2 Expression
    About this image


    GLUD2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Gut Tube (Gastrointestinal Tract)
             Primitive gut tube-like cells ( A scalable, suspension protocol for derivation of...
     
     Testis (Reproductive System)
     
     Liver (Hepatobiliary System)

    See GLUD2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GLUD2

    SOURCE GeneReport for Unigene cluster: Hs.368538

    UniProtKB/Swiss-Prot: DHE4_HUMAN, P49448
    Tissue specificity: Expressed in retina, testis and, at a lower level, brain

        SABiosciences Custom PCR Arrays for GLUD2
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GLUD2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GLUD2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for GLUD2 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves GLUD16
    Glutamate dehydrogenase
    88(a)
    possible ortholog
    6(2134547-2155479)
    lizard
    (Anolis carolinensis)
    Reptilia GLUD16
    GLUD26
    Glutamate dehydrogenase
    85(a)
    67(a)
    possible ortholog
    possible ortholog
    GL343199.1(4105571-4144227)
    GL343526.1(439687-463559)
    zebrafish
    (Danio rerio)
    Actinopterygii glud1a1 glutamate dehydrogenase 1a 74.51(n)
    83.09(a)
      317737  NM_212576.1  NP_997741.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Gdh3 glutamate dehydrogenase (NAD(P)+) 66(a)
    (best of 2)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea ZK829.43 glutamate dehydrogenase 62(a)   IV(11953424-11955386)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GDH1(YOR375C)4 NADP(+)-dependent glutamate dehydrogenase, synthesizes more   --   15(1043042-1041678) 854557  NP_015020.1 
            Species with no ortholog for GLUD2

    ENSEMBL Gene Tree for GLUD2 (if available)
    TreeFam Gene Tree for GLUD2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GLUD2 gene
    GLUD12  
    1 SIMAP similar gene for GLUD2 using alignment to 2 protein entries:     DHE4_HUMAN (see all proteins):
    GLUD1

    GLUD2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/93 SNPs in GLUD2 are shown (see all 93)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs97803621,2
    C,F,H--120133437(+) gctaaA/Ttgatg 1 -- us2k17Minor allele frequency- T:0.01NS EA NA 425
    rs1485644451,2
    --120133689(+) TTGGGA/CTATTC 1 -- us2k10--------
    rs1477468291,2
    --120133731(+) GGTACC/TACGCT 1 -- us2k10--------
    rs1839295891,2
    --120133734(+) ACCACA/GCTATT 1 -- us2k10--------
    rs1879196001,2
    --120134006(+) ACTTAC/TGCCTC 1 -- us2k10--------
    rs59097791,2
    C,F,H--120134281(+) TTTGGA/CGTTTG 1 -- us2k1 tfbs322--NS EA NA WA CSA 2406
    rs1512573531,2
    --120134574(+) ATGACA/TGCCGA 1 -- us2k10--------
    rs59562651,2
    C,F--120135309(+) CCTGGG/TTGGCG 1 -- us2k1 tfbs32Minor allele frequency- T:0.50NA 4
    rs59562661,2
    C,F--120135310(+) CTGGTC/TGGCGC 1 -- us2k1 tfbs32Minor allele frequency- T:0.50NA 4
    rs1123606281,2
    C,F--120135323(+) TGCCCG/CCAAAG 1 -- us2k11Minor allele frequency- C:0.00NA 1

    HapMap Linkage Disequilibrium report for GLUD2 (120181462 - 120183796 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for GLUD2: --

    Human Gene Mutation Database (HGMD): GLUD2

    Locus Specific Mutation Databases (LSDB): GLUD2
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300144    OMIM disorders: --

    14 diseases for GLUD2:    About MalaCards
    clostridium difficile    gout    hyperinsulinemic hypoglycemia    machado-joseph disease
    rett syndrome    hypoglycemia    pneumonia    amyotrophic lateral sclerosis
    lateral sclerosis    parkinson's disease    schizophrenia    ataxia
    alzheimer's disease    neuronitis


    GLUD2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): GLUD2
    Human Genome Epidemiology (HuGE) Navigator: GLUD2 (2 documents)

    Export disorders for GLUD2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GLUD2 gene, integrated from 9 sources (see all 88):
    (articles sorted by number of sources associating them with GLUD2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Novel human glutamate dehydrogenase expressed in neural and testicular tissues and encoded by an X-linked intronless gene. (PubMed id 8207021)1, 2, 3, 9 Shashidharan P.... Plaitakis A. (1994)
    2. Nerve tissue-specific human glutamate dehydrogenase that is thermolabile and highly regulated by ADP. (PubMed id 9109504)1, 3, 9 Shashidharan P....Plaitakis A. (1997)
    3. Alpha helical structures in the leader sequence of human GLUD2 glutamate dehydrogenase responsible for mitochondrial import. (PubMed id 22709669)1, 2 Kotzamani D. and Plaitakis A. (2012)
    4. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PubMed id 19156168)1, 4 Need A.C....Goldstein D.B. (2009)
    5. Gain-of-function variant in GLUD2 glutamate dehydroge nase modifies Parkinson's disease onset. (PubMed id 19826450)1, 4 Plaitakis A....Spanaki C. (2009)
    6. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Mitochondrial targeting adaptation of the hominoid-specific glutamate dehydrogenase driven by positive Darwinian selection. (PubMed id 18688271)1, 9 Rosso L....Kaessmann H. (2008)
    9. Properties and molecular evolution of human GLUD2 (neural and testicular tissue-specific) glutamate dehydrogenase. (PubMed id 17924438)1, 9 Kanavouras K....Plaitakis A. (2007)
    10. Birth and adaptive evolution of a hominoid gene that supports high neurotransmitter flux. (PubMed id 15378063)1, 9 Burki F. and Kaessmann H. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2747 HGNC: 4336 AceView: GLUD2 Ensembl:ENSG00000182890 euGenes: HUgn2747
    ECgene: GLUD2 Kegg: 2747 H-InvDB: GLUD2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GLUD2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GLUD2 gene:
    Search GeneIP for patents involving GLUD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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