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Aliases for GLTSCR2 Gene

Aliases for GLTSCR2 Gene

  • Glioma Tumor Suppressor Candidate Region Gene 2 2 3
  • P60 3 4
  • Protein Interacting With Carboxyl Terminus 1 3
  • PICT-1 3
  • PICT1 3

External Ids for GLTSCR2 Gene

Previous GeneCards Identifiers for GLTSCR2 Gene

  • GC19P048895
  • GC19P048639
  • GC19P052924
  • GC19P052940
  • GC19P052934
  • GC19P048248
  • GC19P044676

Summaries for GLTSCR2 Gene

GeneCards Summary for GLTSCR2 Gene

GLTSCR2 (Glioma Tumor Suppressor Candidate Region Gene 2) is a Protein Coding gene. Among its related pathways are Influenza A. GO annotations related to this gene include poly(A) RNA binding.

Gene Wiki entry for GLTSCR2 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLTSCR2 Gene

Genomics for GLTSCR2 Gene

Regulatory Elements for GLTSCR2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GLTSCR2 Gene

Chromosome:
19
Start:
47,745,522 bp from pter
End:
47,757,066 bp from pter
Size:
11,545 bases
Orientation:
Plus strand

Genomic View for GLTSCR2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GLTSCR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLTSCR2 Gene

Proteins for GLTSCR2 Gene

  • Protein details for GLTSCR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZM5-GSCR2_HUMAN
    Recommended name:
    Glioma tumor suppressor candidate region gene 2 protein
    Protein Accession:
    Q9NZM5
    Secondary Accessions:
    • Q9BTC6
    • Q9HAX6
    • Q9NPP1
    • Q9NPR4
    • Q9UFI2

    Protein attributes for GLTSCR2 Gene

    Size:
    478 amino acids
    Molecular mass:
    54389 Da
    Quaternary structure:
    • Interacts with HSV-1 early proteins ICP22 and ICP0

neXtProt entry for GLTSCR2 Gene

Proteomics data for GLTSCR2 Gene at MOPED

Post-translational modifications for GLTSCR2 Gene

  • Ubiquitination at Lys 375 and Lys 432
  • Modification sites at PhosphoSitePlus

Other Protein References for GLTSCR2 Gene

No data available for DME Specific Peptides for GLTSCR2 Gene

Domains & Families for GLTSCR2 Gene

Protein Domains for GLTSCR2 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9NZM5

UniProtKB/Swiss-Prot:

GSCR2_HUMAN :
  • Belongs to the GLTSCR2 family.
Family:
  • Belongs to the GLTSCR2 family.
genes like me logo Genes that share domains with GLTSCR2: view

No data available for Gene Families for GLTSCR2 Gene

Function for GLTSCR2 Gene

Gene Ontology (GO) - Molecular Function for GLTSCR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with GLTSCR2: view
genes like me logo Genes that share phenotypes with GLTSCR2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GLTSCR2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for GLTSCR2 Gene

Localization for GLTSCR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLTSCR2 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GLTSCR2 Gene COMPARTMENTS Subcellular localization image for GLTSCR2 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for GLTSCR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular NAS 10196275
GO:0005730 nucleolus IDA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with GLTSCR2: view

Pathways & Interactions for GLTSCR2 Gene

SuperPathways for GLTSCR2 Gene

Superpath Contained pathways
1 Influenza A
genes like me logo Genes that share pathways with GLTSCR2: view

Pathways by source for GLTSCR2 Gene

1 KEGG pathway for GLTSCR2 Gene

Gene Ontology (GO) - Biological Process for GLTSCR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with GLTSCR2: view

No data available for SIGNOR curated interactions for GLTSCR2 Gene

Drugs & Compounds for GLTSCR2 Gene

No Compound Related Data Available

Transcripts for GLTSCR2 Gene

Unigene Clusters for GLTSCR2 Gene

Glioma tumor suppressor candidate region gene 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GLTSCR2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GLTSCR2 Gene

No ASD Table

Relevant External Links for GLTSCR2 Gene

GeneLoc Exon Structure for
GLTSCR2
ECgene alternative splicing isoforms for
GLTSCR2

Expression for GLTSCR2 Gene

mRNA expression in normal human tissues for GLTSCR2 Gene

Protein differential expression in normal tissues from HIPED for GLTSCR2 Gene

This gene is overexpressed in Lung (31.3) and Plasma (11.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GLTSCR2 Gene



SOURCE GeneReport for Unigene cluster for GLTSCR2 Gene Hs.421907

mRNA Expression by UniProt/SwissProt for GLTSCR2 Gene

Q9NZM5-GSCR2_HUMAN
Tissue specificity: Expressed at high levels in heart and pancreas, moderate levels in placenta, liver, skeletal muscle, and kidney, and low levels in brain and lung.
genes like me logo Genes that share expression patterns with GLTSCR2: view

Protein tissue co-expression partners for GLTSCR2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for GLTSCR2 Gene

Orthologs for GLTSCR2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GLTSCR2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GLTSCR2 35
  • 85.36 (n)
  • 85.36 (a)
GLTSCR2 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GLTSCR2 35
  • 86.15 (n)
  • 86.3 (a)
GLTSCR2 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gltscr2 35
  • 81.24 (n)
  • 82.01 (a)
Gltscr2 16
Gltscr2 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GLTSCR2 35
  • 99.09 (n)
  • 98.95 (a)
GLTSCR2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gltscr2 35
  • 80.61 (n)
  • 81.8 (a)
oppossum
(Monodelphis domestica)
Mammalia GLTSCR2 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GLTSCR2 36
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 36 (a)
OneToMany
-- 36
  • 56 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia gltscr2 35
  • 55.21 (n)
  • 53.57 (a)
Str.527 35
zebrafish
(Danio rerio)
Actinopterygii gltscr2 35
  • 56.75 (n)
  • 55.75 (a)
gltscr2 36
  • 50 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000270 35
  • 48.8 (n)
  • 32.04 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1785 35
  • 48.09 (n)
  • 33.09 (a)
CG1785 36
  • 27 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_Y39B6A.33 35
  • 41.21 (n)
  • 30.65 (a)
Y39B6A.33 36
  • 25 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR126W 35
  • 44.27 (n)
  • 32.29 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F11506g 35
  • 39.74 (n)
  • 28.46 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NOP53 35
  • 37.43 (n)
  • 29.1 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU05233 35
  • 48.81 (n)
  • 35.62 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rrp16 35
  • 39.56 (n)
  • 30.13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4906 36
  • 39 (a)
OneToOne
Species with no ortholog for GLTSCR2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GLTSCR2 Gene

ENSEMBL:
Gene Tree for GLTSCR2 (if available)
TreeFam:
Gene Tree for GLTSCR2 (if available)

Paralogs for GLTSCR2 Gene

(1) SIMAP similar genes for GLTSCR2 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for GLTSCR2 Gene

genes like me logo Genes that share paralogs with GLTSCR2: view

No data available for Paralogs for GLTSCR2 Gene

Variants for GLTSCR2 Gene

Sequence variations from dbSNP and Humsavar for GLTSCR2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs753729 -- 47,756,893(+) AGCGG(A/G)GTTGG intron-variant
rs889142 -- 47,756,822(+) CCCCT(C/T)CCAGA intron-variant
rs889143 -- 47,756,977(+) CCCTC(A/G)GCTCC intron-variant
rs1042401 - 47,745,607(+) AAAAG(A/C)GATGC missense, reference
rs1042558 -- 47,752,547(+) CAGGC(A/G)CCCGC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for GLTSCR2 Gene

Variant ID Type Subtype PubMed ID
nsv912206 CNV Loss 21882294
dgv3964n71 CNV Loss 21882294
nsv912210 CNV Gain 21882294
nsv912211 CNV Loss 21882294

Variation tolerance for GLTSCR2 Gene

Residual Variation Intolerance Score: 88.22% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.36; 70.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GLTSCR2 Gene

HapMap Linkage Disequilibrium report
GLTSCR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLTSCR2 Gene

Disorders for GLTSCR2 Gene

Relevant External Links for GLTSCR2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GLTSCR2
genes like me logo Genes that share disorders with GLTSCR2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GLTSCR2 Gene

Publications for GLTSCR2 Gene

  1. The putative tumor suppressor gene GLTSCR2 induces PTEN-modulated cell death. (PMID: 17657248) Yim J.H. … Park J.H. (Cell Death Differ. 2007) 2 23 67
  2. Critical role of PICT-1, a tumor suppressor candidate, in phosphatidylinositol 3,4,5-trisphosphate signals and tumorigenic transformation. (PMID: 16971513) Okahara F. … Maehama T. (Mol. Biol. Cell 2006) 2 23 67
  3. GLTSCR2/PICT-1, a putative tumor suppressor gene product, induces the nucleolar targeting of the Kaposi's sarcoma-associated herpesvirus KS-Bcl-2 protein. (PMID: 20042497) Kalt I. … Sarid R. (J. Virol. 2010) 23 67
  4. Suppression of putative tumour suppressor gene GLTSCR2 expression in human glioblastomas. (PMID: 18729076) Kim Y.J. … Park J.H. (J. Pathol. 2008) 23 67
  5. A transcript map of the chromosome 19q-Arm glioma tumor suppressor region. (PMID: 10708517) Smith J.S. … Jenkins R.B. (Genomics 2000) 2 67

Products for GLTSCR2 Gene

Sources for GLTSCR2 Gene

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