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Aliases for GLTSCR1 Gene

Aliases for GLTSCR1 Gene

  • Glioma Tumor Suppressor Candidate Region Gene 1 2 3 5

External Ids for GLTSCR1 Gene

Previous GeneCards Identifiers for GLTSCR1 Gene

  • GC19P048828
  • GC19P048573
  • GC19P052858
  • GC19P052874
  • GC19P048111
  • GC19P044540

Summaries for GLTSCR1 Gene

GeneCards Summary for GLTSCR1 Gene

GLTSCR1 (Glioma Tumor Suppressor Candidate Region Gene 1) is a Protein Coding gene. Diseases associated with GLTSCR1 include Glioma and Acoustic Neuroma. An important paralog of this gene is GLTSCR1L.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLTSCR1 Gene

Genomics for GLTSCR1 Gene

Regulatory Elements for GLTSCR1 Gene

Enhancers for GLTSCR1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F047239 1.9 FANTOM5 Ensembl ENCODE 94.4 -366.0 -365996 6.4 CREB3L1 ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF416 ZNF548 ZNF263 ZC3H4 GLTSCR1 ENSG00000268810 ENSG00000269321 CCDC9 GLTSCR2-AS1 EHD2 SLC1A5 PRKD2 TPRX2P
GH19F047225 1.2 ENCODE 81.7 -378.8 -378815 8.2 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 ZNF263 SP3 ZC3H4 GLTSCR1 CCDC9 ENSG00000268810 GLTSCR2-AS1 ENSG00000269321 SLC1A5 PRKD2 SNORD23 ENSG00000268746
GH19F046727 1.8 FANTOM5 Ensembl ENCODE 36.8 -876.8 -876838 6.9 HDGF PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 SLC30A9 ZNF302 ZC3H4 GLTSCR1 ENSG00000268810 CCDC61 PRKD2 STRN4 ENSG00000259605 ENSG00000268746 MIR320E GNG8
GH19F046638 1.1 ENCODE 57.7 -968.8 -968848 2.4 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A YBX1 FEZF1 ZNF2 ZC3H4 GLTSCR1 CCDC61 CCDC9 FBXO46 ENSG00000269148 SLC1A5 ENSG00000268810 ENSG00000268746 IRF2BP1
GH19F047209 1.3 Ensembl ENCODE 47.4 -397.8 -397791 2.6 HDGF PKNOX1 MLX CREB3L1 ARID4B SIN3A ZNF143 KLF13 ZNF263 REST ZC3H4 GLTSCR2-AS1 GLTSCR1 ENSG00000268810 CCDC9 BBC3 MIR3191 SLC1A5 SAE1 TMEM160
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GLTSCR1 on UCSC Golden Path with GeneCards custom track

Promoters for GLTSCR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000347816 904 3401 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 FOS ZNF263

Genomic Location for GLTSCR1 Gene

Chromosome:
19
Start:
47,608,196 bp from pter
End:
47,703,277 bp from pter
Size:
95,082 bases
Orientation:
Plus strand

Genomic View for GLTSCR1 Gene

Genes around GLTSCR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GLTSCR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GLTSCR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLTSCR1 Gene

Proteins for GLTSCR1 Gene

  • Protein details for GLTSCR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZM4-GSCR1_HUMAN
    Recommended name:
    Glioma tumor suppressor candidate region gene 1 protein
    Protein Accession:
    Q9NZM4
    Secondary Accessions:
    • A8MW01

    Protein attributes for GLTSCR1 Gene

    Size:
    1560 amino acids
    Molecular mass:
    158490 Da
    Quaternary structure:
    • Interacts with BRD4.
    SequenceCaution:
    • Sequence=AAF62874.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for GLTSCR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GLTSCR1 Gene

Post-translational modifications for GLTSCR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GLTSCR1 Gene

No data available for DME Specific Peptides for GLTSCR1 Gene

Domains & Families for GLTSCR1 Gene

Protein Domains for GLTSCR1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GLTSCR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GLTSCR1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for GLTSCR1 Gene

Function for GLTSCR1 Gene

Gene Ontology (GO) - Molecular Function for GLTSCR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17474147
genes like me logo Genes that share ontologies with GLTSCR1: view
genes like me logo Genes that share phenotypes with GLTSCR1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GLTSCR1 Gene

Localization for GLTSCR1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GLTSCR1 gene
Compartment Confidence
nucleus 4
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GLTSCR1 Gene

Pathways & Interactions for GLTSCR1 Gene

SuperPathways for GLTSCR1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GLTSCR1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GLTSCR1 Gene

Transcripts for GLTSCR1 Gene

Unigene Clusters for GLTSCR1 Gene

Glioma tumor suppressor candidate region gene 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GLTSCR1 Gene

No ASD Table

Relevant External Links for GLTSCR1 Gene

GeneLoc Exon Structure for
GLTSCR1
ECgene alternative splicing isoforms for
GLTSCR1

Expression for GLTSCR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GLTSCR1 Gene

Protein differential expression in normal tissues from HIPED for GLTSCR1 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (32.1), Rectum (16.7), Pancreatic juice (8.6), and Peripheral blood mononuclear cells (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GLTSCR1 Gene



Protein tissue co-expression partners for GLTSCR1 Gene

NURSA nuclear receptor signaling pathways regulating expression of GLTSCR1 Gene:

GLTSCR1

SOURCE GeneReport for Unigene cluster for GLTSCR1 Gene:

Hs.97244

mRNA Expression by UniProt/SwissProt for GLTSCR1 Gene:

Q9NZM4-GSCR1_HUMAN
Tissue specificity: Expressed at moderate levels in heart, brain, placenta, skeletal muscle, and pancreas, and at lower levels in lung, liver and kidney.
genes like me logo Genes that share expression patterns with GLTSCR1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for GLTSCR1 Gene

Orthologs for GLTSCR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GLTSCR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GLTSCR1 34 35
  • 99.29 (n)
dog
(Canis familiaris)
Mammalia GLTSCR1 34 35
  • 88.62 (n)
rat
(Rattus norvegicus)
Mammalia Gltscr1 34
  • 82.43 (n)
mouse
(Mus musculus)
Mammalia Gltscr1 34 16 35
  • 82.37 (n)
cow
(Bos Taurus)
Mammalia GLTSCR1 35
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 73 (a)
OneToMany
-- 35
  • 69 (a)
OneToMany
chicken
(Gallus gallus)
Aves LOC101749950 34
  • 72.69 (n)
GLTSCR1 35
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GLTSCR1 35
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gltscr1 34
  • 63.16 (n)
zebrafish
(Danio rerio)
Actinopterygii gltscr1 35
  • 32 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 28 (a)
OneToMany
Species where no ortholog for GLTSCR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GLTSCR1 Gene

ENSEMBL:
Gene Tree for GLTSCR1 (if available)
TreeFam:
Gene Tree for GLTSCR1 (if available)

Paralogs for GLTSCR1 Gene

Paralogs for GLTSCR1 Gene

Pseudogenes.org Pseudogenes for GLTSCR1 Gene

genes like me logo Genes that share paralogs with GLTSCR1: view

Variants for GLTSCR1 Gene

Sequence variations from dbSNP and Humsavar for GLTSCR1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1005911 -- 47,702,835(+) GGTCC(G/T)TCCAG utr-variant-3-prime
rs1012003 -- 47,658,874(-) AGGGG(A/G)AAAAA intron-variant
rs1035938 -- 47,680,514(+) ATGAG(C/T)GTCCA reference, synonymous-codon
rs10402373 -- 47,671,977(+) ggtgg(C/G)tgggt intron-variant
rs10402923 -- 47,642,312(+) ctgta(C/T)gagtc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GLTSCR1 Gene

Variant ID Type Subtype PubMed ID
nsv953593 CNV deletion 24416366
nsv953592 CNV deletion 24416366
nsv579889 CNV loss 21841781
nsv579888 CNV gain 21841781
nsv521727 CNV loss 19592680
nsv1143922 CNV deletion 24896259
nsv1114018 CNV deletion 24896259
nsv1059189 CNV gain 25217958
esv3644557 CNV loss 21293372
esv3644556 CNV loss 21293372
esv3556494 CNV deletion 23714750
esv23734 CNV loss 19812545
dgv6507n54 CNV loss 21841781
dgv6506n54 CNV loss 21841781
dgv1790n106 CNV deletion 24896259

Variation tolerance for GLTSCR1 Gene

Gene Damage Index Score: 10.72; 91.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GLTSCR1 Gene

Human Gene Mutation Database (HGMD)
GLTSCR1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GLTSCR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLTSCR1 Gene

Disorders for GLTSCR1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for GLTSCR1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
glioma
acoustic neuroma
  • vestibular neurilemmoma
neuroma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for GLTSCR1

Genetic Association Database (GAD)
GLTSCR1
Human Genome Epidemiology (HuGE) Navigator
GLTSCR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GLTSCR1
genes like me logo Genes that share disorders with GLTSCR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GLTSCR1 Gene

Publications for GLTSCR1 Gene

  1. The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3. (PMID: 21555454) Rahman S. … Howley P.M. (Mol. Cell. Biol. 2011) 2 3 4 64
  2. A transcript map of the chromosome 19q-Arm glioma tumor suppressor region. (PMID: 10708517) Smith J.S. … Jenkins R.B. (Genomics 2000) 2 3 4 64
  3. Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure. (PMID: 22174851) Lingappa J.R. … Goldstein D. (PLoS ONE 2011) 3 46 64
  4. DNA repair gene polymorphisms and risk of adult meningioma, glioma, and acoustic neuroma. (PMID: 20150366) Rajaraman P. … Inskip P.D. (Neuro-oncology 2010) 3 46 64
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64

Products for GLTSCR1 Gene

Sources for GLTSCR1 Gene

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