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Aliases for GLTSCR1 Gene

Aliases for GLTSCR1 Gene

  • Glioma Tumor Suppressor Candidate Region Gene 1 2 3

External Ids for GLTSCR1 Gene

Previous GeneCards Identifiers for GLTSCR1 Gene

  • GC19P048828
  • GC19P048573
  • GC19P052858
  • GC19P052874
  • GC19P048111
  • GC19P044540

Summaries for GLTSCR1 Gene

GeneCards Summary for GLTSCR1 Gene

GLTSCR1 (Glioma Tumor Suppressor Candidate Region Gene 1) is a Protein Coding gene. Diseases associated with GLTSCR1 include acoustic neuroma and neuroma. An important paralog of this gene is GLTSCR1L.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLTSCR1 Gene

Genomics for GLTSCR1 Gene

Regulatory Elements for GLTSCR1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GLTSCR1 Gene

47,608,196 bp from pter
47,703,277 bp from pter
95,082 bases
Plus strand

Genomic View for GLTSCR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GLTSCR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLTSCR1 Gene

Proteins for GLTSCR1 Gene

  • Protein details for GLTSCR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Glioma tumor suppressor candidate region gene 1 protein
    Protein Accession:
    Secondary Accessions:
    • A8MW01

    Protein attributes for GLTSCR1 Gene

    1560 amino acids
    Molecular mass:
    158490 Da
    Quaternary structure:
    • Interacts with BRD4.
    • Sequence=AAF62874.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for GLTSCR1 Gene


neXtProt entry for GLTSCR1 Gene

Proteomics data for GLTSCR1 Gene at MOPED

Post-translational modifications for GLTSCR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GLTSCR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GLTSCR1 Gene

Domains & Families for GLTSCR1 Gene

Protein Domains for GLTSCR1 Gene


Suggested Antigen Peptide Sequences for GLTSCR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GLTSCR1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for GLTSCR1 Gene

Function for GLTSCR1 Gene

Gene Ontology (GO) - Molecular Function for GLTSCR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17474147
genes like me logo Genes that share ontologies with GLTSCR1: view
genes like me logo Genes that share phenotypes with GLTSCR1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GLTSCR1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for GLTSCR1 Gene

Localization for GLTSCR1 Gene

Subcellular locations from

Jensen Localization Image for GLTSCR1 Gene COMPARTMENTS Subcellular localization image for GLTSCR1 gene
Compartment Confidence
nucleus 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GLTSCR1 Gene

Pathways & Interactions for GLTSCR1 Gene

SuperPathways for GLTSCR1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GLTSCR1 Gene


No data available for Pathways by source and SIGNOR curated interactions for GLTSCR1 Gene

Drugs & Compounds for GLTSCR1 Gene

No Compound Related Data Available

Transcripts for GLTSCR1 Gene

Unigene Clusters for GLTSCR1 Gene

Glioma tumor suppressor candidate region gene 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GLTSCR1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GLTSCR1 Gene

No ASD Table

Relevant External Links for GLTSCR1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GLTSCR1 Gene

mRNA expression in normal human tissues for GLTSCR1 Gene

Protein differential expression in normal tissues from HIPED for GLTSCR1 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (32.1), Rectum (16.7), Pancreatic juice (8.6), and Peripheral blood mononuclear cells (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for GLTSCR1 Gene

SOURCE GeneReport for Unigene cluster for GLTSCR1 Gene Hs.97244

mRNA Expression by UniProt/SwissProt for GLTSCR1 Gene

Tissue specificity: Expressed at moderate levels in heart, brain, placenta, skeletal muscle, and pancreas, and at lower levels in lung, liver and kidney.
genes like me logo Genes that share expression patterns with GLTSCR1: view

Protein tissue co-expression partners for GLTSCR1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for GLTSCR1 Gene

Orthologs for GLTSCR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GLTSCR1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GLTSCR1 36
  • 99 (a)
  • 99.29 (n)
  • 99.29 (a)
(Mus musculus)
Mammalia Gltscr1 36
  • 85 (a)
Gltscr1 16
Gltscr1 35
  • 82.37 (n)
  • 87.85 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 69 (a)
-- 36
  • 73 (a)
(Canis familiaris)
Mammalia GLTSCR1 36
  • 89 (a)
  • 88.62 (n)
  • 91.12 (a)
(Bos Taurus)
Mammalia GLTSCR1 36
  • 77 (a)
(Rattus norvegicus)
Mammalia Gltscr1 35
  • 82.43 (n)
  • 88.1 (a)
(Gallus gallus)
Aves GLTSCR1 36
  • 53 (a)
LOC101749950 35
  • 72.69 (n)
  • 72.69 (a)
(Anolis carolinensis)
Reptilia GLTSCR1 36
  • 43 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gltscr1 35
  • 63.16 (n)
  • 65.14 (a)
(Danio rerio)
Actinopterygii gltscr1 36
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
Species with no ortholog for GLTSCR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GLTSCR1 Gene

Gene Tree for GLTSCR1 (if available)
Gene Tree for GLTSCR1 (if available)

Paralogs for GLTSCR1 Gene

Paralogs for GLTSCR1 Gene Pseudogenes for GLTSCR1 Gene

genes like me logo Genes that share paralogs with GLTSCR1: view

Variants for GLTSCR1 Gene

Sequence variations from dbSNP and Humsavar for GLTSCR1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs15143 -- 47,703,153(-) TAGTT(A/T)TGTCT utr-variant-3-prime
rs870359 -- 47,606,762(+) atagc(A/G)ttgcg upstream-variant-2KB
rs882686 -- 47,666,235(-) CATGC(G/T)CACAG intron-variant
rs889337 -- 47,681,290(-) CTTGC(C/T)CCGCC intron-variant
rs889338 -- 47,661,913(-) CTGGG(A/C)TCAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GLTSCR1 Gene

Variant ID Type Subtype PubMed ID
nsv912203 CNV Gain 21882294
nsv912204 CNV Gain 21882294
nsv912205 CNV Loss 21882294
nsv912206 CNV Loss 21882294
nsv912207 CNV Loss 21882294
esv23734 CNV Loss 19812545
dgv3964n71 CNV Loss 21882294
nsv521727 CNV Loss 19592680
nsv912210 CNV Gain 21882294

Variation tolerance for GLTSCR1 Gene

Gene Damage Index Score: 10.72; 91.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GLTSCR1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLTSCR1 Gene

Disorders for GLTSCR1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for GLTSCR1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
acoustic neuroma
  • vestibular schwannoma
- elite association

Relevant External Links for GLTSCR1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GLTSCR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GLTSCR1 Gene

Publications for GLTSCR1 Gene

  1. A transcript map of the chromosome 19q-Arm glioma tumor suppressor region. (PMID: 10708517) Smith J.S. … Jenkins R.B. (Genomics 2000) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67
  4. The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3. (PMID: 21555454) Rahman S. … Howley P.M. (Mol. Cell. Biol. 2011) 67
  5. Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure. (PMID: 22174851) Lingappa J.R. … Goldstein D. (PLoS ONE 2011) 67

Products for GLTSCR1 Gene

Sources for GLTSCR1 Gene

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