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Aliases for GLTPD2 Gene

Aliases for GLTPD2 Gene

  • Glycolipid Transfer Protein Domain Containing 2 2 3 5

External Ids for GLTPD2 Gene

Previous GeneCards Identifiers for GLTPD2 Gene

  • GC17P004639
  • GC17P004692
  • GC17P004580

Summaries for GLTPD2 Gene

GeneCards Summary for GLTPD2 Gene

GLTPD2 (Glycolipid Transfer Protein Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include glycolipid binding and glycolipid transporter activity. An important paralog of this gene is CPTP.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLTPD2 Gene

Genomics for GLTPD2 Gene

Regulatory Elements for GLTPD2 Gene

Enhancers for GLTPD2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GLTPD2 on UCSC Golden Path with GeneCards custom track

Promoters for GLTPD2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GLTPD2 on UCSC Golden Path with GeneCards custom track

Genomic Location for GLTPD2 Gene

Chromosome:
17
Start:
4,788,422 bp from pter
End:
4,790,592 bp from pter
Size:
2,171 bases
Orientation:
Plus strand

Genomic View for GLTPD2 Gene

Genes around GLTPD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GLTPD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GLTPD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLTPD2 Gene

Proteins for GLTPD2 Gene

  • Protein details for GLTPD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NH11-GLTD2_HUMAN
    Recommended name:
    Glycolipid transfer protein domain-containing protein 2
    Protein Accession:
    A6NH11
    Secondary Accessions:
    • A7E2T2

    Protein attributes for GLTPD2 Gene

    Size:
    291 amino acids
    Molecular mass:
    31642 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GLTPD2 Gene

Proteomics data for GLTPD2 Gene at MOPED

Post-translational modifications for GLTPD2 Gene

  • Glycosylation at Thr 64 and Asn 276
  • Modification sites at PhosphoSitePlus

Other Protein References for GLTPD2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GLTPD2 Gene

Domains & Families for GLTPD2 Gene

Protein Domains for GLTPD2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GLTPD2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NH11

UniProtKB/Swiss-Prot:

GLTD2_HUMAN :
  • Belongs to the GLTP family.
Family:
  • Belongs to the GLTP family.
genes like me logo Genes that share domains with GLTPD2: view

No data available for Gene Families for GLTPD2 Gene

Function for GLTPD2 Gene

Gene Ontology (GO) - Molecular Function for GLTPD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051861 glycolipid binding IEA --
genes like me logo Genes that share ontologies with GLTPD2: view

Phenotypes for GLTPD2 Gene

GenomeRNAi human phenotypes for GLTPD2:
genes like me logo Genes that share phenotypes with GLTPD2: view

Animal Model Products

CRISPR Products

miRNA for GLTPD2 Gene

miRTarBase miRNAs that target GLTPD2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GLTPD2 Gene

Localization for GLTPD2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GLTPD2 Gene COMPARTMENTS Subcellular localization image for GLTPD2 gene
Compartment Confidence
extracellular 2
cytosol 1
golgi apparatus 1
lysosome 1
mitochondrion 1
peroxisome 1
plasma membrane 1
vacuole 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GLTPD2 Gene

Pathways & Interactions for GLTPD2 Gene

SuperPathways for GLTPD2 Gene

No Data Available

Interacting Proteins for GLTPD2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000328070%0d%0a9606.ENSP00000368646%0d%0a9606.ENSP00000222008%0d%0a
Selected Interacting proteins: ENSP00000328070 for GLTPD2 Gene via STRING

Gene Ontology (GO) - Biological Process for GLTPD2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GLTPD2 Gene

Drugs & Compounds for GLTPD2 Gene

(3) Drugs for GLTPD2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sphingosine Experimental Pharma 0
sphinganine Pharma 0
Sphingosine-1-phosphate Pharma Full agonist, Agonist Endogenous agonist at S1P1-5 0

(462) Additional Compounds for GLTPD2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-Dehydrosphinganine
  • (2S)-2-amino-1-hydroxyoctadecan-3-one
  • 1-Hydroxy-2-amino-3-oxo-octadecane
  • 2-Amino-1-hydroxy-3-Octadecanone
  • 3-Dehydro-D-sphinganine
  • 3-Dehydrosphinganine
16105-69-4
3-O-Sulfogalactosylceramide (d18:1/12:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
852100-88-0
3-O-Sulfogalactosylceramide (d18:1/14:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
3-O-Sulfogalactosylceramide (d18:1/16:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
862509-48-6
3-O-Sulfogalactosylceramide (d18:1/18:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
244215-65-4
genes like me logo Genes that share compounds with GLTPD2: view

Transcripts for GLTPD2 Gene

mRNA/cDNA for GLTPD2 Gene

Unigene Clusters for GLTPD2 Gene

Glycolipid transfer protein domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GLTPD2 Gene

No ASD Table

Relevant External Links for GLTPD2 Gene

GeneLoc Exon Structure for
GLTPD2
ECgene alternative splicing isoforms for
GLTPD2

Expression for GLTPD2 Gene

mRNA expression in normal human tissues for GLTPD2 Gene

mRNA differential expression in normal tissues according to GTEx for GLTPD2 Gene

This gene is overexpressed in Liver (x31.5) and Kidney - Cortex (x4.6).

Protein differential expression in normal tissues from HIPED for GLTPD2 Gene

This gene is overexpressed in Liver (37.1) and Fetal Liver (31.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GLTPD2 Gene



SOURCE GeneReport for Unigene cluster for GLTPD2 Gene Hs.131035

genes like me logo Genes that share expression patterns with GLTPD2: view

Protein tissue co-expression partners for GLTPD2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for GLTPD2 Gene

Orthologs for GLTPD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for GLTPD2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GLTPD2 35
  • 78.14 (n)
  • 69.53 (a)
GLTPD2 36
  • 61 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GLTPD2 35
  • 78.9 (n)
  • 71.94 (a)
GLTPD2 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gltpd2 35
  • 73.56 (n)
  • 65.17 (a)
Gltpd2 16
Gltpd2 36
  • 58 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GLTPD2 35
  • 98.97 (n)
  • 97.59 (a)
GLTPD2 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gltpd2 35
  • 73.59 (n)
  • 66.55 (a)
oppossum
(Monodelphis domestica)
Mammalia GLTPD2 36
  • 42 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GLTPD2 36
  • 33 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii gltpd2 36
  • 25 (a)
OneToMany
GLTPD2 (1 of 2) 36
  • 25 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG30392 36
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea K08E4.2 36
  • 20 (a)
ManyToMany
tag-296 36
  • 19 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.402 36
  • 19 (a)
OneToMany
Species with no ortholog for GLTPD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GLTPD2 Gene

ENSEMBL:
Gene Tree for GLTPD2 (if available)
TreeFam:
Gene Tree for GLTPD2 (if available)

Paralogs for GLTPD2 Gene

Paralogs for GLTPD2 Gene

(1) SIMAP similar genes for GLTPD2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GLTPD2: view

Variants for GLTPD2 Gene

Sequence variations from dbSNP and Humsavar for GLTPD2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs2304969 -- 4,789,264(-) TGGAA(A/C)GCAGG reference, missense
rs8080212 -- 4,791,042(+) ttttt(C/T)gtttt downstream-variant-500B
rs8080230 -- 4,791,064(+) tcttt(C/T)ttttt downstream-variant-500B
rs10713262 -- 4,788,473(+) ACAAA(A/C)AAAAA upstream-variant-2KB, utr-variant-5-prime
rs34421346 -- 4,790,213(+) CGCTG(C/G)TCCGG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for GLTPD2 Gene

Variant ID Type Subtype PubMed ID
nsv833346 CNV Loss 17160897
nsv907618 CNV Loss 21882294
nsv833347 CNV Loss 17160897

Variation tolerance for GLTPD2 Gene

Residual Variation Intolerance Score: 77.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.66; 72.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GLTPD2 Gene

HapMap Linkage Disequilibrium report
GLTPD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLTPD2 Gene

Disorders for GLTPD2 Gene

Relevant External Links for GLTPD2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GLTPD2

No disorders were found for GLTPD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GLTPD2 Gene

Publications for GLTPD2 Gene

  1. Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis. (PMID: 22916037) Inouye M. … de Bakker P.I. (PLoS Genet. 2012) 3 67
  2. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for GLTPD2 Gene

Sources for GLTPD2 Gene

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