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Aliases for GLT8D2 Gene

Aliases for GLT8D2 Gene

  • Glycosyltransferase 8 Domain Containing 2 2 3 5
  • EC 2.4.1.- 4
  • EC 2.4.1 61
  • GALA4A 4

External Ids for GLT8D2 Gene

Previous GeneCards Identifiers for GLT8D2 Gene

  • GC12M102886
  • GC12M104382
  • GC12M101442

Summaries for GLT8D2 Gene

GeneCards Summary for GLT8D2 Gene

GLT8D2 (Glycosyltransferase 8 Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring glycosyl groups. An important paralog of this gene is GLT8D1.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLT8D2 Gene

Genomics for GLT8D2 Gene

Regulatory Elements for GLT8D2 Gene

Enhancers for GLT8D2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G104279 1.7 FANTOM5 Ensembl ENCODE dbSUPER 1.3 -216.7 -216738 3.7 TBP FOXA2 BRCA1 RARA RFX5 GATA2 ZNF366 RCOR1 FOS EGR2 EID3 TXNRD1 GLT8D2 ENSG00000257732
GH12G104055 0.9 Ensembl ENCODE 0.4 +7.6 7584 1.6 FOXA2 HLF ZMYM3 MAX REST RAD21 YY1 JUND HNF4A ZBTB33 NFYB TDG NT5DC3 GLT8D2 PIR60229 GC12P104032 GC12P104033 GC12P104034 GC12P104035
GH12G104048 0.8 ENCODE 0.4 +14.5 14467 2.5 BCOR ZMYM3 ZNF76 ZNF384 ZNF776 ZNF366 ADNP PATZ1 ZNF239 ZNF600 TDG C12orf73 ENSG00000257681 GLT8D2 PIR60229 GC12P104035 GC12P104034 GC12P104033 GC12P104032
GH12G104045 0.8 Ensembl ENCODE 0.4 +18.8 18784 0.8 NFIC ZNF366 NR2F1 ZNF512 NR2F6 GC12P104035 GC12P104034 GC12P104033 GC12P104032 PIR60229 GLT8D2
GH12G104057 0.6 ENCODE 0.4 +6.3 6316 0.1 CTCF ZNF654 CBX3 ZNF740 TRIM22 REST RAD21 SMC3 ZNF143 TRIM28 TDG NT5DC3 GLT8D2 PIR60229 GC12P104032 GC12P104033 GC12P104034 GC12P104035
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GLT8D2 on UCSC Golden Path with GeneCards custom track

Promoters for GLT8D2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000056493 -417 2001 PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 FEZF1 ZNF2 YY1 ZNF766

Genomic Location for GLT8D2 Gene

Chromosome:
12
Start:
103,988,984 bp from pter
End:
104,064,183 bp from pter
Size:
75,200 bases
Orientation:
Minus strand

Genomic View for GLT8D2 Gene

Genes around GLT8D2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GLT8D2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GLT8D2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLT8D2 Gene

Proteins for GLT8D2 Gene

  • Protein details for GLT8D2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H1C3-GL8D2_HUMAN
    Recommended name:
    Glycosyltransferase 8 domain-containing protein 2
    Protein Accession:
    Q9H1C3
    Secondary Accessions:
    • Q96KA2

    Protein attributes for GLT8D2 Gene

    Size:
    349 amino acids
    Molecular mass:
    40026 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GLT8D2 Gene

Selected DME Specific Peptides for GLT8D2 Gene

Q9H1C3:
  • GHAAAFS
  • VLKGKIRPDSSRPELLQPLNFVRFYLPLL
  • RIRKWIEHSKLREINFKIVEFNP
  • AKLLHWNG
  • FYVVGLR
  • DDDVIVQGDI

Post-translational modifications for GLT8D2 Gene

  • Glycosylation at isoforms=234
  • Modification sites at PhosphoSitePlus

Other Protein References for GLT8D2 Gene

Domains & Families for GLT8D2 Gene

Gene Families for GLT8D2 Gene

Protein Domains for GLT8D2 Gene

Suggested Antigen Peptide Sequences for GLT8D2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H1C3

UniProtKB/Swiss-Prot:

GL8D2_HUMAN :
  • Belongs to the glycosyltransferase 8 family.
Family:
  • Belongs to the glycosyltransferase 8 family.
genes like me logo Genes that share domains with GLT8D2: view

Function for GLT8D2 Gene

Enzyme Numbers (IUBMB) for GLT8D2 Gene

Gene Ontology (GO) - Molecular Function for GLT8D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IBA --
genes like me logo Genes that share ontologies with GLT8D2: view
genes like me logo Genes that share phenotypes with GLT8D2: view

Animal Models for GLT8D2 Gene

MGI Knock Outs for GLT8D2:

Animal Model Products

  • Taconic Biosciences Mouse Models for GLT8D2

CRISPR Products

miRNA for GLT8D2 Gene

miRTarBase miRNAs that target GLT8D2

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GLT8D2 Gene

Localization for GLT8D2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLT8D2 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GLT8D2 gene
Compartment Confidence
golgi apparatus 5
extracellular 2
endoplasmic reticulum 2
cytosol 2

Gene Ontology (GO) - Cellular Components for GLT8D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GLT8D2: view

Pathways & Interactions for GLT8D2 Gene

SuperPathways for GLT8D2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GLT8D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000271 polysaccharide biosynthetic process IBA --
genes like me logo Genes that share ontologies with GLT8D2: view

No data available for Pathways by source and SIGNOR curated interactions for GLT8D2 Gene

Drugs & Compounds for GLT8D2 Gene

No Compound Related Data Available

Transcripts for GLT8D2 Gene

Unigene Clusters for GLT8D2 Gene

Glycosyltransferase 8 domain containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GLT8D2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11
SP1: -
SP2: - -
SP3:

Relevant External Links for GLT8D2 Gene

GeneLoc Exon Structure for
GLT8D2
ECgene alternative splicing isoforms for
GLT8D2

Expression for GLT8D2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GLT8D2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GLT8D2 Gene

This gene is overexpressed in Ovary (59.9) and Placenta (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GLT8D2 Gene



Protein tissue co-expression partners for GLT8D2 Gene

NURSA nuclear receptor signaling pathways regulating expression of GLT8D2 Gene:

GLT8D2

SOURCE GeneReport for Unigene cluster for GLT8D2 Gene:

Hs.631650
genes like me logo Genes that share expression patterns with GLT8D2: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GLT8D2 Gene

Orthologs for GLT8D2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GLT8D2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GLT8D2 34 35
  • 99.43 (n)
dog
(Canis familiaris)
Mammalia GLT8D2 34 35
  • 91.02 (n)
cow
(Bos Taurus)
Mammalia GLT8D2 34 35
  • 90.49 (n)
mouse
(Mus musculus)
Mammalia Glt8d2 34 16 35
  • 87.32 (n)
rat
(Rattus norvegicus)
Mammalia Glt8d2 34
  • 86.13 (n)
oppossum
(Monodelphis domestica)
Mammalia GLT8D2 35
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 83 (a)
OneToMany
-- 35
  • 68 (a)
OneToMany
chicken
(Gallus gallus)
Aves GLT8D2 34 35
  • 77.2 (n)
lizard
(Anolis carolinensis)
Reptilia GLT8D2 35
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia glt8d2 34
  • 66.96 (n)
zebrafish
(Danio rerio)
Actinopterygii glt8d2 34 35
  • 65.12 (n)
Species where no ortholog for GLT8D2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GLT8D2 Gene

ENSEMBL:
Gene Tree for GLT8D2 (if available)
TreeFam:
Gene Tree for GLT8D2 (if available)

Paralogs for GLT8D2 Gene

Variants for GLT8D2 Gene

Sequence variations from dbSNP and Humsavar for GLT8D2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000076763 -- 104,024,380(+) GTGAG(A/C)CATGG intron-variant
rs1000180409 -- 104,061,405(+) TAAGG(A/G)CATTA intron-variant
rs1000183104 -- 104,030,058(+) AAAAC(G/T)GAAGG intron-variant
rs1000206894 -- 104,065,731(+) GCTCT(A/G)CCGGT intron-variant, upstream-variant-2KB
rs1000228046 -- 104,021,351(+) AAGTC(A/G)CTTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GLT8D2 Gene

Variant ID Type Subtype PubMed ID
esv2746311 CNV deletion 23290073
esv2746312 CNV deletion 23290073
esv3580445 CNV loss 25503493
esv3581849 CNV gain 25503493
nsv560039 CNV gain 21841781
nsv973113 CNV duplication 23825009

Variation tolerance for GLT8D2 Gene

Residual Variation Intolerance Score: 86.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.88; 35.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GLT8D2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GLT8D2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLT8D2 Gene

Disorders for GLT8D2 Gene

Relevant External Links for GLT8D2

Genetic Association Database (GAD)
GLT8D2
Human Genome Epidemiology (HuGE) Navigator
GLT8D2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GLT8D2

No disorders were found for GLT8D2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GLT8D2 Gene

Publications for GLT8D2 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for GLT8D2 Gene

Sources for GLT8D2 Gene

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