Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GLT8D2 Gene

Aliases for GLT8D2 Gene

  • Glycosyltransferase 8 Domain Containing 2 2 3 5
  • EC 2.4.1.- 4
  • EC 2.4.1 61
  • GALA4A 4

External Ids for GLT8D2 Gene

Previous GeneCards Identifiers for GLT8D2 Gene

  • GC12M102886
  • GC12M104382
  • GC12M101442

Summaries for GLT8D2 Gene

GeneCards Summary for GLT8D2 Gene

GLT8D2 (Glycosyltransferase 8 Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring glycosyl groups. An important paralog of this gene is GLT8D1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLT8D2 Gene

Genomics for GLT8D2 Gene

Regulatory Elements for GLT8D2 Gene

Enhancers for GLT8D2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F103955 1.2 ENCODE 13.8 +107.2 107237 2.6 HDGF ARNT CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 GLT8D2 C12orf73 MIR3652 HSP90B1 TTC41P HCFC2 TDG GC12P103942
GH12F103927 1.2 ENCODE 13.8 +133.8 133836 6.4 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 GLT8D2 HCFC2 TTC41P C12orf73 NT5DC3 ENSG00000257681 GC12P103932 GC12P103934
GH12F103570 1.4 Ensembl ENCODE 10 +492.7 492710 1.4 HDGF PKNOX1 MLX ARNT CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 STAB2 NFYB ENSG00000212594 C12orf42 GLT8D2 GC12P103574 LOC101929084
GH12F103964 1.2 ENCODE 10.1 +98.2 98232 3.1 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 C12orf73 NFYB TTC41P MIR3652 HSP90B1 GLT8D2 TDG GC12P104022
GH12F104279 1.4 FANTOM5 Ensembl ENCODE 1.3 -216.7 -216738 3.7 BCOR TBP JUN ZMYM3 ZNF384 BRCA1 RARA RFX5 ZFHX2 ZNF366 EID3 TXNRD1 GLT8D2 ENSG00000257732
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GLT8D2 on UCSC Golden Path with GeneCards custom track

Promoters for GLT8D2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000090579 -617 2801 PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF207

Genomic Location for GLT8D2 Gene

103,988,984 bp from pter
104,064,183 bp from pter
75,200 bases
Minus strand

Genomic View for GLT8D2 Gene

Genes around GLT8D2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GLT8D2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GLT8D2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLT8D2 Gene

Proteins for GLT8D2 Gene

  • Protein details for GLT8D2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Glycosyltransferase 8 domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • Q96KA2

    Protein attributes for GLT8D2 Gene

    349 amino acids
    Molecular mass:
    40026 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GLT8D2 Gene

Selected DME Specific Peptides for GLT8D2 Gene


Post-translational modifications for GLT8D2 Gene

  • Glycosylation at Asn 234
  • Modification sites at PhosphoSitePlus

Other Protein References for GLT8D2 Gene

Domains & Families for GLT8D2 Gene

Gene Families for GLT8D2 Gene

Protein Domains for GLT8D2 Gene

Suggested Antigen Peptide Sequences for GLT8D2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyltransferase 8 family.
  • Belongs to the glycosyltransferase 8 family.
genes like me logo Genes that share domains with GLT8D2: view

Function for GLT8D2 Gene

Enzyme Numbers (IUBMB) for GLT8D2 Gene

Gene Ontology (GO) - Molecular Function for GLT8D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IBA --
genes like me logo Genes that share ontologies with GLT8D2: view
genes like me logo Genes that share phenotypes with GLT8D2: view

Animal Models for GLT8D2 Gene

MGI Knock Outs for GLT8D2:

Animal Model Products

  • Taconic Biosciences Mouse Models for GLT8D2

miRNA for GLT8D2 Gene

miRTarBase miRNAs that target GLT8D2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GLT8D2 Gene

Localization for GLT8D2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLT8D2 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GLT8D2 gene
Compartment Confidence
golgi apparatus 5
extracellular 2
endoplasmic reticulum 2
cytosol 2

Gene Ontology (GO) - Cellular Components for GLT8D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GLT8D2: view

Pathways & Interactions for GLT8D2 Gene

SuperPathways for GLT8D2 Gene

No Data Available

Interacting Proteins for GLT8D2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q9H1C3-GL8D2_HUMAN ENSP00000354053 for GLT8D2 Gene via IID STRING

Gene Ontology (GO) - Biological Process for GLT8D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000271 polysaccharide biosynthetic process IBA --
genes like me logo Genes that share ontologies with GLT8D2: view

No data available for Pathways by source and SIGNOR curated interactions for GLT8D2 Gene

Transcripts for GLT8D2 Gene

Unigene Clusters for GLT8D2 Gene

Glycosyltransferase 8 domain containing 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GLT8D2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11
SP1: -
SP2: - -

Relevant External Links for GLT8D2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GLT8D2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GLT8D2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GLT8D2 Gene

This gene is overexpressed in Ovary (59.9) and Placenta (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GLT8D2 Gene

Protein tissue co-expression partners for GLT8D2 Gene

NURSA nuclear receptor signaling pathways regulating expression of GLT8D2 Gene:


SOURCE GeneReport for Unigene cluster for GLT8D2 Gene:

genes like me logo Genes that share expression patterns with GLT8D2: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GLT8D2 Gene

Orthologs for GLT8D2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GLT8D2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GLT8D2 34 35
  • 99.43 (n)
(Canis familiaris)
Mammalia GLT8D2 34 35
  • 91.02 (n)
(Bos Taurus)
Mammalia GLT8D2 34 35
  • 90.49 (n)
(Mus musculus)
Mammalia Glt8d2 34 16 35
  • 87.32 (n)
(Rattus norvegicus)
Mammalia Glt8d2 34
  • 86.13 (n)
(Monodelphis domestica)
Mammalia GLT8D2 35
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 83 (a)
-- 35
  • 68 (a)
(Gallus gallus)
Aves GLT8D2 34 35
  • 77.2 (n)
(Anolis carolinensis)
Reptilia GLT8D2 35
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia glt8d2 34
  • 66.96 (n)
(Danio rerio)
Actinopterygii glt8d2 34 35
  • 65.12 (n)
Species where no ortholog for GLT8D2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GLT8D2 Gene

Gene Tree for GLT8D2 (if available)
Gene Tree for GLT8D2 (if available)

Paralogs for GLT8D2 Gene

Variants for GLT8D2 Gene

Sequence variations from dbSNP and Humsavar for GLT8D2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1038497 -- 104,050,645(-) AGAAC(A/C)CACCG intron-variant, utr-variant-5-prime
rs10467025 -- 104,039,939(+) ggcac(A/T)tatac intron-variant
rs10503 -- 103,988,486(+) CTGCT(A/G)TTTAC intron-variant, utr-variant-3-prime
rs10571369 -- 104,012,171(+) GTCTC(-/AA)AAAAA intron-variant
rs1061224 -- 104,032,353(+) GATTT(C/T)TGAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GLT8D2 Gene

Variant ID Type Subtype PubMed ID
esv2746311 CNV deletion 23290073
esv2746312 CNV deletion 23290073
esv3580445 CNV loss 25503493
esv3581849 CNV gain 25503493
nsv560039 CNV gain 21841781
nsv973113 CNV duplication 23825009

Variation tolerance for GLT8D2 Gene

Residual Variation Intolerance Score: 86.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.88; 35.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GLT8D2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLT8D2 Gene

Disorders for GLT8D2 Gene

Relevant External Links for GLT8D2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GLT8D2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GLT8D2 Gene

Publications for GLT8D2 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  5. Mechanism of the effect of glycosyltransferase GLT8D2 on fatty liver. (PMID: 25952508) Zhan Y. … An W. (Lipids Health Dis 2015) 3 64

Products for GLT8D2 Gene

Sources for GLT8D2 Gene

Loading form....