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Aliases for GLT8D2 Gene

Aliases for GLT8D2 Gene

  • Glycosyltransferase 8 Domain Containing 2 2 3
  • Gycosyltransferase 3
  • EC 2.4.1.- 4
  • EC 2.4.1 63
  • GALA4A 4

External Ids for GLT8D2 Gene

Previous GeneCards Identifiers for GLT8D2 Gene

  • GC12M102886
  • GC12M104382
  • GC12M101442

Summaries for GLT8D2 Gene

GeneCards Summary for GLT8D2 Gene

GLT8D2 (Glycosyltransferase 8 Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring glycosyl groups. An important paralog of this gene is GLT8D1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLT8D2 Gene

Genomics for GLT8D2 Gene

Regulatory Elements for GLT8D2 Gene

Genomic Location for GLT8D2 Gene

Chromosome:
12
Start:
103,988,984 bp from pter
End:
104,064,183 bp from pter
Size:
75,200 bases
Orientation:
Minus strand

Genomic View for GLT8D2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GLT8D2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLT8D2 Gene

Proteins for GLT8D2 Gene

  • Protein details for GLT8D2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H1C3-GL8D2_HUMAN
    Recommended name:
    Glycosyltransferase 8 domain-containing protein 2
    Protein Accession:
    Q9H1C3
    Secondary Accessions:
    • Q96KA2

    Protein attributes for GLT8D2 Gene

    Size:
    349 amino acids
    Molecular mass:
    40026 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GLT8D2 Gene

Proteomics data for GLT8D2 Gene at MOPED

Post-translational modifications for GLT8D2 Gene

  • Glycosylation at Asn 234
  • Modification sites at PhosphoSitePlus

Other Protein References for GLT8D2 Gene

Domains & Families for GLT8D2 Gene

Gene Families for GLT8D2 Gene

Protein Domains for GLT8D2 Gene

Suggested Antigen Peptide Sequences for GLT8D2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H1C3

UniProtKB/Swiss-Prot:

GL8D2_HUMAN :
  • Belongs to the glycosyltransferase 8 family.
Family:
  • Belongs to the glycosyltransferase 8 family.
genes like me logo Genes that share domains with GLT8D2: view

Function for GLT8D2 Gene

Enzyme Numbers (IUBMB) for GLT8D2 Gene

Gene Ontology (GO) - Molecular Function for GLT8D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016757 transferase activity, transferring glycosyl groups IBA --
genes like me logo Genes that share ontologies with GLT8D2: view
genes like me logo Genes that share phenotypes with GLT8D2: view

Animal Model Products

miRNA for GLT8D2 Gene

miRTarBase miRNAs that target GLT8D2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GLT8D2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Animal Models , Transcription Factor Targets and HOMER Transcription for GLT8D2 Gene

Localization for GLT8D2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLT8D2 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GLT8D2 Gene COMPARTMENTS Subcellular localization image for GLT8D2 gene
Compartment Confidence
cytosol 2

Gene Ontology (GO) - Cellular Components for GLT8D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IBA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GLT8D2: view

Pathways & Interactions for GLT8D2 Gene

SuperPathways for GLT8D2 Gene

No Data Available

Interacting Proteins for GLT8D2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000354053%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000354053 for GLT8D2 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for GLT8D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000271 polysaccharide biosynthetic process IBA --
GO:0008152 metabolic process --
genes like me logo Genes that share ontologies with GLT8D2: view

No data available for Pathways by source and SIGNOR curated interactions for GLT8D2 Gene

Drugs & Compounds for GLT8D2 Gene

No Compound Related Data Available

Transcripts for GLT8D2 Gene

Unigene Clusters for GLT8D2 Gene

Glycosyltransferase 8 domain containing 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GLT8D2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GLT8D2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11
SP1: -
SP2: - -
SP3:

Relevant External Links for GLT8D2 Gene

GeneLoc Exon Structure for
GLT8D2
ECgene alternative splicing isoforms for
GLT8D2

Expression for GLT8D2 Gene

mRNA expression in normal human tissues for GLT8D2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GLT8D2 Gene

This gene is overexpressed in Ovary (59.9) and Placenta (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for GLT8D2 Gene



SOURCE GeneReport for Unigene cluster for GLT8D2 Gene Hs.631650

genes like me logo Genes that share expression patterns with GLT8D2: view

Protein tissue co-expression partners for GLT8D2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GLT8D2 Gene

Orthologs for GLT8D2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GLT8D2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GLT8D2 35
  • 90.49 (n)
  • 95.39 (a)
GLT8D2 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GLT8D2 35
  • 91.02 (n)
  • 94.27 (a)
GLT8D2 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Glt8d2 35
  • 87.32 (n)
  • 92.8 (a)
Glt8d2 16
Glt8d2 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GLT8D2 35
  • 99.43 (n)
  • 99.71 (a)
GLT8D2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Glt8d2 35
  • 86.13 (n)
  • 92.2 (a)
oppossum
(Monodelphis domestica)
Mammalia GLT8D2 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 68 (a)
OneToMany
-- 36
  • 83 (a)
OneToMany
chicken
(Gallus gallus)
Aves GLT8D2 35
  • 77.2 (n)
  • 81.16 (a)
GLT8D2 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GLT8D2 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia glt8d2 35
  • 66.96 (n)
  • 69.01 (a)
zebrafish
(Danio rerio)
Actinopterygii glt8d2 35
  • 65.12 (n)
  • 62.9 (a)
glt8d2 36
  • 59 (a)
OneToOne
Species with no ortholog for GLT8D2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GLT8D2 Gene

ENSEMBL:
Gene Tree for GLT8D2 (if available)
TreeFam:
Gene Tree for GLT8D2 (if available)

Paralogs for GLT8D2 Gene

Paralogs for GLT8D2 Gene

genes like me logo Genes that share paralogs with GLT8D2: view

Variants for GLT8D2 Gene

Sequence variations from dbSNP and Humsavar for GLT8D2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1038497 -- 104,050,645(-) AGAAC(A/C)CACCG upstream-variant-2KB, intron-variant
rs1061224 -- 104,032,353(+) GATTT(C/T)TGAAT intron-variant
rs1061279 -- 104,032,403(+) TTCAT(C/T)TGAGC intron-variant
rs1142245 -- 104,032,463(+) TGCaa(A/T)aaaaa intron-variant
rs1183215 -- 104,008,321(+) aactg(G/T)aacaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GLT8D2 Gene

Variant ID Type Subtype PubMed ID
esv2746311 CNV Deletion 23290073
esv2746312 CNV Deletion 23290073

Variation tolerance for GLT8D2 Gene

Residual Variation Intolerance Score: 86.32% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.88; 35.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GLT8D2 Gene

HapMap Linkage Disequilibrium report
GLT8D2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLT8D2 Gene

Disorders for GLT8D2 Gene

Relevant External Links for GLT8D2

Genetic Association Database (GAD)
GLT8D2
Human Genome Epidemiology (HuGE) Navigator
GLT8D2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GLT8D2
genes like me logo Genes that share disorders with GLT8D2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GLT8D2 Gene

Publications for GLT8D2 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  2. Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus. (PMID: 23291589) Lu Y. … Wong T.Y. (Nat. Genet. 2013) 67
  3. Glycosyltransferase GLT8D2 positively regulates ApoB100 protein expression in hepatocytes. (PMID: 24173238) Wei H.S. … Zhan Y.T. (Int J Mol Sci 2013) 67
  4. Genome-wide association study identifies variants associated with progression of liver fibrosis from HCV infection. (PMID: 22841784) Patin E. … . (Gastroenterology 2012) 67
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 67

Products for GLT8D2 Gene

Sources for GLT8D2 Gene

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