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Aliases for GLT8D1 Gene

Aliases for GLT8D1 Gene

  • Glycosyltransferase 8 Domain Containing 1 2 3 5
  • Glycosyltransferase AD-017 3
  • EC 2.4.1.- 4
  • EC 2.4.1 63
  • MSTP139 3
  • AD-017 3
  • GALA4A 4

External Ids for GLT8D1 Gene

Summaries for GLT8D1 Gene

Entrez Gene Summary for GLT8D1 Gene

  • This gene encodes a member of the glycosyltransferase family. The specific function of this protein has not been determined. Alternative splicing results in multiple transcript variants of this gene [provided by RefSeq, May 2013]

GeneCards Summary for GLT8D1 Gene

GLT8D1 (Glycosyltransferase 8 Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring glycosyl groups. An important paralog of this gene is GLT8D2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLT8D1 Gene

Genomics for GLT8D1 Gene

Regulatory Elements for GLT8D1 Gene

Promoters for GLT8D1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GLT8D1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the GLT8D1 gene promoter:

Genomic Location for GLT8D1 Gene

Chromosome:
3
Start:
52,694,484 bp from pter
End:
52,706,083 bp from pter
Size:
11,600 bases
Orientation:
Minus strand

Genomic View for GLT8D1 Gene

Genes around GLT8D1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GLT8D1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GLT8D1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLT8D1 Gene

Proteins for GLT8D1 Gene

  • Protein details for GLT8D1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68CQ7-GL8D1_HUMAN
    Recommended name:
    Glycosyltransferase 8 domain-containing protein 1
    Protein Accession:
    Q68CQ7
    Secondary Accessions:
    • Q7Z4D1
    • Q8N2J6
    • Q9P0I5

    Protein attributes for GLT8D1 Gene

    Size:
    371 amino acids
    Molecular mass:
    41935 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAQ13652.1; Type=Frameshift; Positions=26, 52, 66, 75, 85, 300, 309, 315, 317, 349; Evidence={ECO:0000305};

    Alternative splice isoforms for GLT8D1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GLT8D1 Gene

Proteomics data for GLT8D1 Gene at MOPED

Post-translational modifications for GLT8D1 Gene

  • Glycosylation at Asn 103, Asn 249, Asn 257, and Thr 365
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains & Families for GLT8D1 Gene

Gene Families for GLT8D1 Gene

Protein Domains for GLT8D1 Gene

Suggested Antigen Peptide Sequences for GLT8D1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q68CQ7

UniProtKB/Swiss-Prot:

GL8D1_HUMAN :
  • Belongs to the glycosyltransferase 8 family.
Family:
  • Belongs to the glycosyltransferase 8 family.
genes like me logo Genes that share domains with GLT8D1: view

Function for GLT8D1 Gene

Enzyme Numbers (IUBMB) for GLT8D1 Gene

genes like me logo Genes that share phenotypes with GLT8D1: view

Animal Model Products

miRNA for GLT8D1 Gene

miRTarBase miRNAs that target GLT8D1

No data available for Molecular function , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GLT8D1 Gene

Localization for GLT8D1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLT8D1 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GLT8D1 Gene COMPARTMENTS Subcellular localization image for GLT8D1 gene
Compartment Confidence
golgi apparatus 4
extracellular 2
mitochondrion 2
endoplasmic reticulum 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for GLT8D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GLT8D1: view

Pathways & Interactions for GLT8D1 Gene

SuperPathways for GLT8D1 Gene

No Data Available

Interacting Proteins for GLT8D1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000266014%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000266014 for GLT8D1 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for GLT8D1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GLT8D1 Gene

Drugs & Compounds for GLT8D1 Gene

No Compound Related Data Available

Transcripts for GLT8D1 Gene

Unigene Clusters for GLT8D1 Gene

Glycosyltransferase 8 domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GLT8D1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13a ·
SP1: - - - - - - - - - - - - - -
SP2: -
SP3: - - - - - - - - -
SP4:
SP5: - - - - - - -
SP6:
SP7: - - - - - -
SP8: - - - - - -
SP9: - - - -
SP10: - - - - - - - - - - - - - - - - -
SP11: - - - - - - -
SP12: - - - - - - - - -
SP13: - -
SP14: -
SP15:
SP16:
SP17:
SP18: - - - - -

ExUns: 13b ^ 14a · 14b ^ 15a · 15b · 15c ^ 16a · 16b · 16c ^ 17 ^ 18a · 18b · 18c
SP1: -
SP2: -
SP3:
SP4: -
SP5:
SP6: - - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14: - -
SP15:
SP16:
SP17:
SP18:

Relevant External Links for GLT8D1 Gene

GeneLoc Exon Structure for
GLT8D1
ECgene alternative splicing isoforms for
GLT8D1

Expression for GLT8D1 Gene

mRNA expression in normal human tissues for GLT8D1 Gene

Protein differential expression in normal tissues from HIPED for GLT8D1 Gene

This gene is overexpressed in Islet of Langerhans (18.2), Pancreatic juice (9.3), Placenta (7.9), and Testis (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for GLT8D1 Gene



SOURCE GeneReport for Unigene cluster for GLT8D1 Gene Hs.297304

genes like me logo Genes that share expression patterns with GLT8D1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for GLT8D1 Gene

Orthologs for GLT8D1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GLT8D1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GLT8D1 35
  • 90.66 (n)
  • 92.18 (a)
GLT8D1 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GLT8D1 35
  • 91.64 (n)
  • 92.45 (a)
GLT8D1 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Glt8d1 35
  • 89.49 (n)
  • 90.84 (a)
Glt8d1 16
Glt8d1 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GLT8D1 35
  • 99.64 (n)
  • 99.73 (a)
GLT8D1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Glt8d1 35
  • 89.49 (n)
  • 90.84 (a)
oppossum
(Monodelphis domestica)
Mammalia GLT8D1 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GLT8D1 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves GLT8D1 35
  • 74.32 (n)
  • 76.78 (a)
GLT8D1 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GLT8D1 36
  • 73 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.9402 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.9985 35
zebrafish
(Danio rerio)
Actinopterygii glt8d1 35
  • 65.55 (n)
  • 63.69 (a)
glt8d1 36
  • 62 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons GATL6 35
  • 46.83 (n)
  • 34.92 (a)
Species with no ortholog for GLT8D1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GLT8D1 Gene

ENSEMBL:
Gene Tree for GLT8D1 (if available)
TreeFam:
Gene Tree for GLT8D1 (if available)

Paralogs for GLT8D1 Gene

Paralogs for GLT8D1 Gene

(1) SIMAP similar genes for GLT8D1 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with GLT8D1: view

Variants for GLT8D1 Gene

Sequence variations from dbSNP and Humsavar for GLT8D1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs2276812 - 52,695,944(+) CTCCA(C/T)GGATG reference, missense
rs1963813 -- 52,699,410(-) ctact(C/T)gggag intron-variant
rs2164885 -- 52,697,253(-) AATCC(A/G)TTTTG intron-variant
rs3733041 -- 52,697,582(+) AAATA(C/T)GTCAT intron-variant
rs3733042 -- 52,700,209(+) ACAGA(C/G)AATAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GLT8D1 Gene

Variant ID Type Subtype PubMed ID
esv991877 CNV Insertion 20482838

Variation tolerance for GLT8D1 Gene

Residual Variation Intolerance Score: 25.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.35; 53.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GLT8D1 Gene

HapMap Linkage Disequilibrium report
GLT8D1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLT8D1 Gene

Disorders for GLT8D1 Gene

Relevant External Links for GLT8D1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GLT8D1

No disorders were found for GLT8D1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GLT8D1 Gene

Publications for GLT8D1 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 67
  2. Investigation of association between hip osteoarthritis susceptibility loci and radiographic proximal femur shape. (PMID: 25939412) Lindner C. … Wallis G.A. ( 2015) 3
  3. ITIH3 polymorphism may confer susceptibility to psychiatric disorders by altering the expression levels of GLT8D1. (PMID: 24373612) Sasayama D. … Kunugi H. (J Psychiatr Res 2014) 3
  4. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) (Nature 2014) 3
  5. Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. (PMID: 23453885) (Lancet 2013) 3

Products for GLT8D1 Gene

Sources for GLT8D1 Gene

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