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Aliases for GLT8D1 Gene

Aliases for GLT8D1 Gene

  • Glycosyltransferase 8 Domain Containing 1 2 3 5
  • Glycosyltransferase 8 Domain-Containing Protein 1 3
  • Glycosyltransferase AD-017 3
  • EC 2.4.1.- 4
  • EC 2.4.1 61
  • MSTP139 3
  • AD-017 3
  • GALA4A 4

External Ids for GLT8D1 Gene

Summaries for GLT8D1 Gene

Entrez Gene Summary for GLT8D1 Gene

  • This gene encodes a member of the glycosyltransferase family. The specific function of this protein has not been determined. Alternative splicing results in multiple transcript variants of this gene [provided by RefSeq, May 2013]

GeneCards Summary for GLT8D1 Gene

GLT8D1 (Glycosyltransferase 8 Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring glycosyl groups. An important paralog of this gene is GLT8D2.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLT8D1 Gene

Genomics for GLT8D1 Gene

Regulatory Elements for GLT8D1 Gene

Enhancers for GLT8D1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G053165 1.5 FANTOM5 ENCODE dbSUPER 4.5 -462.9 -462879 7.4 HDGF PKNOX1 FOXA2 WRNIP1 ARID4B DMAP1 ZNF207 ZNF263 SP5 MIER2 PRKCD TMEM110 GLT8D1 TKT GNL3 DCP1A PBRM1
GH03G052243 1.8 FANTOM5 ENCODE dbSUPER 1.9 +460.2 460198 4.9 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 PBRM1 PPM1M LOC101929054 GLYCTK IQCF2 IQCF5 PHF7 IQCF6 IQCF1 WDR82
GH03G052703 1.4 ENCODE dbSUPER 0.7 +0.3 347 4.6 HDGF PKNOX1 FOXA2 MLX CREB3L1 AGO1 ZFP64 WRNIP1 ARID4B SIN3A PBRM1 RFT1 RRP9 GLT8D1 SPCS1
GH03G052618 0.3 FANTOM5 3 +87.7 87656 0.4 ITIH1 GLT8D1 GLYCTK MUSTN1 RNU6ATAC16P GNL3
GH03G052719 1.1 Ensembl ENCODE dbSUPER 0.4 -15.4 -15365 3.1 CBX3 ZNF680 MAX ZNF316 CBX5 EED TRIM24 MAFK MYC ZNF558 PBRM1 GNL3 SNORD69 ENSG00000222345 ENSG00000252787 SNORD19 SNORD19B ITIH1 STAB1 SFMBT1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GLT8D1 on UCSC Golden Path with GeneCards custom track

Promoters for GLT8D1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000152584 83 2401 HDGF PKNOX1 FOXA2 MLX CREB3L1 AGO1 ZFP64 WRNIP1 ARID4B SIN3A

Transcription factor binding sites by QIAGEN in the GLT8D1 gene promoter:

Genomic Location for GLT8D1 Gene

Chromosome:
3
Start:
52,694,484 bp from pter
End:
52,706,083 bp from pter
Size:
11,600 bases
Orientation:
Minus strand

Genomic View for GLT8D1 Gene

Genes around GLT8D1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GLT8D1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GLT8D1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLT8D1 Gene

Proteins for GLT8D1 Gene

  • Protein details for GLT8D1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68CQ7-GL8D1_HUMAN
    Recommended name:
    Glycosyltransferase 8 domain-containing protein 1
    Protein Accession:
    Q68CQ7
    Secondary Accessions:
    • Q7Z4D1
    • Q8N2J6
    • Q9P0I5

    Protein attributes for GLT8D1 Gene

    Size:
    371 amino acids
    Molecular mass:
    41935 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAQ13652.1; Type=Frameshift; Positions=26, 52, 66, 75, 85, 300, 309, 315, 317, 349; Evidence={ECO:0000305};

    Alternative splice isoforms for GLT8D1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GLT8D1 Gene

Selected DME Specific Peptides for GLT8D1 Gene

Q68CQ7:
  • KPLTFARFYLPILVP
  • GHAAAFS
  • PPLLIVFY
  • TADHLRSWL
  • TCSFNPGVFVANLTEW
  • KWYIPDPTGKF
  • FLLVLHHN
  • AKLLHWNG
  • IDPMWNVRHLG
  • NQYNYIG
  • DDDVIVQGDI
  • VRHLGSS
  • LDYKKERIR

Post-translational modifications for GLT8D1 Gene

  • Glycosylation at isoforms=2103, Asn249, Asn257, and isoforms=365
  • Modification sites at PhosphoSitePlus

Domains & Families for GLT8D1 Gene

Gene Families for GLT8D1 Gene

Protein Domains for GLT8D1 Gene

Suggested Antigen Peptide Sequences for GLT8D1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q68CQ7

UniProtKB/Swiss-Prot:

GL8D1_HUMAN :
  • Belongs to the glycosyltransferase 8 family.
Family:
  • Belongs to the glycosyltransferase 8 family.
genes like me logo Genes that share domains with GLT8D1: view

Function for GLT8D1 Gene

Enzyme Numbers (IUBMB) for GLT8D1 Gene

Gene Ontology (GO) - Molecular Function for GLT8D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA,IBA --
genes like me logo Genes that share ontologies with GLT8D1: view
genes like me logo Genes that share phenotypes with GLT8D1: view

Animal Models for GLT8D1 Gene

MGI Knock Outs for GLT8D1:

Animal Model Products

  • Taconic Biosciences Mouse Models for GLT8D1

CRISPR Products

miRNA for GLT8D1 Gene

miRTarBase miRNAs that target GLT8D1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GLT8D1 Gene

Localization for GLT8D1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLT8D1 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GLT8D1 gene
Compartment Confidence
golgi apparatus 4
extracellular 2
mitochondrion 2
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for GLT8D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IBA --
GO:0016020 membrane IEA,IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GLT8D1: view

Pathways & Interactions for GLT8D1 Gene

SuperPathways for GLT8D1 Gene

No Data Available

Interacting Proteins for GLT8D1 Gene

Gene Ontology (GO) - Biological Process for GLT8D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000271 polysaccharide biosynthetic process IBA --
genes like me logo Genes that share ontologies with GLT8D1: view

No data available for Pathways by source and SIGNOR curated interactions for GLT8D1 Gene

Transcripts for GLT8D1 Gene

Unigene Clusters for GLT8D1 Gene

Glycosyltransferase 8 domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GLT8D1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13a ·
SP1: - - - - - - - - - - - - - -
SP2: -
SP3: - - - - - - - - -
SP4:
SP5: - - - - - - -
SP6:
SP7: - - - - - -
SP8: - - - - - -
SP9: - - - -
SP10: - - - - - - - - - - - - - - - - -
SP11: - - - - - - -
SP12: - - - - - - - - -
SP13: - -
SP14: -
SP15:
SP16:
SP17:
SP18: - - - - -

ExUns: 13b ^ 14a · 14b ^ 15a · 15b · 15c ^ 16a · 16b · 16c ^ 17 ^ 18a · 18b · 18c
SP1: -
SP2: -
SP3:
SP4: -
SP5:
SP6: - - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14: - -
SP15:
SP16:
SP17:
SP18:

Relevant External Links for GLT8D1 Gene

GeneLoc Exon Structure for
GLT8D1
ECgene alternative splicing isoforms for
GLT8D1

Expression for GLT8D1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GLT8D1 Gene

Protein differential expression in normal tissues from HIPED for GLT8D1 Gene

This gene is overexpressed in Islet of Langerhans (18.2), Pancreatic juice (9.3), Placenta (7.9), and Testis (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GLT8D1 Gene



NURSA nuclear receptor signaling pathways regulating expression of GLT8D1 Gene:

GLT8D1

SOURCE GeneReport for Unigene cluster for GLT8D1 Gene:

Hs.297304

Evidence on tissue expression from TISSUES for GLT8D1 Gene

  • Adrenal gland(4.3)
  • Liver(4.3)
  • Nervous system(3.3)
genes like me logo Genes that share expression patterns with GLT8D1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GLT8D1 Gene

Orthologs for GLT8D1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GLT8D1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GLT8D1 34 35
  • 99.64 (n)
dog
(Canis familiaris)
Mammalia GLT8D1 34 35
  • 91.64 (n)
cow
(Bos Taurus)
Mammalia GLT8D1 34 35
  • 90.66 (n)
mouse
(Mus musculus)
Mammalia Glt8d1 34 16 35
  • 89.49 (n)
rat
(Rattus norvegicus)
Mammalia Glt8d1 34
  • 89.49 (n)
oppossum
(Monodelphis domestica)
Mammalia GLT8D1 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GLT8D1 35
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves GLT8D1 34 35
  • 74.32 (n)
lizard
(Anolis carolinensis)
Reptilia GLT8D1 35
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.9985 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.9402 34
zebrafish
(Danio rerio)
Actinopterygii glt8d1 34 35
  • 65.55 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons GATL6 34
  • 46.83 (n)
Species where no ortholog for GLT8D1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GLT8D1 Gene

ENSEMBL:
Gene Tree for GLT8D1 (if available)
TreeFam:
Gene Tree for GLT8D1 (if available)

Paralogs for GLT8D1 Gene

Paralogs for GLT8D1 Gene

(1) SIMAP similar genes for GLT8D1 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with GLT8D1: view

Variants for GLT8D1 Gene

Sequence variations from dbSNP and Humsavar for GLT8D1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000322546 -- 52,697,456(+) TATTA(C/T)TATCA intron-variant
rs1000379708 -- 52,697,137(+) ACTAA(A/G)TATGA intron-variant
rs1000525756 -- 52,697,230(+) GTTTT(A/T)TAAGT intron-variant
rs1000579401 -- 52,705,405(+) CTAGG(A/G)TAGCC intron-variant, upstream-variant-2KB
rs1000652330 -- 52,703,641(+) GAGAT(A/G)ATGTT intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for GLT8D1 Gene

Variant ID Type Subtype PubMed ID
esv3336498 CNV insertion 20981092
esv991877 CNV insertion 20482838

Variation tolerance for GLT8D1 Gene

Residual Variation Intolerance Score: 25.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.35; 53.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GLT8D1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GLT8D1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLT8D1 Gene

Disorders for GLT8D1 Gene

Relevant External Links for GLT8D1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GLT8D1

No disorders were found for GLT8D1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GLT8D1 Gene

Publications for GLT8D1 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  4. Investigation of association between hip osteoarthritis susceptibility loci and radiographic proximal femur shape. (PMID: 25939412) Lindner C. … Wallis G.A. ( 2015) 3 64
  5. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) (Nature 2014) 3 64

Products for GLT8D1 Gene

Sources for GLT8D1 Gene

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