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Aliases for GLT1D1 Gene

Aliases for GLT1D1 Gene

  • Glycosyltransferase 1 Domain Containing 1 2 3
  • EC 2.4.-.- 4

External Ids for GLT1D1 Gene

Previous GeneCards Identifiers for GLT1D1 Gene

  • GC12P127863
  • GC12P129337
  • GC12P126322

Summaries for GLT1D1 Gene

GeneCards Summary for GLT1D1 Gene

GLT1D1 (Glycosyltransferase 1 Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring glycosyl groups.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLT1D1 Gene

Genomics for GLT1D1 Gene

Regulatory Elements for GLT1D1 Gene

Transcription factor binding sites by QIAGEN in the GLT1D1 gene promoter:

Genomic Location for GLT1D1 Gene

Chromosome:
12
Start:
128,853,427 bp from pter
End:
128,984,968 bp from pter
Size:
131,542 bases
Orientation:
Plus strand

Genomic View for GLT1D1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GLT1D1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLT1D1 Gene

Proteins for GLT1D1 Gene

  • Protein details for GLT1D1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96MS3-GL1D1_HUMAN
    Recommended name:
    Glycosyltransferase 1 domain-containing protein 1
    Protein Accession:
    Q96MS3
    Secondary Accessions:
    • Q86XG8

    Protein attributes for GLT1D1 Gene

    Size:
    346 amino acids
    Molecular mass:
    38507 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GLT1D1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GLT1D1 Gene

Proteomics data for GLT1D1 Gene at MOPED

Post-translational modifications for GLT1D1 Gene

No Post-translational modifications

Other Protein References for GLT1D1 Gene

No data available for DME Specific Peptides for GLT1D1 Gene

Domains & Families for GLT1D1 Gene

Gene Families for GLT1D1 Gene

Protein Domains for GLT1D1 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GLT1D1 Gene

Graphical View of Domain Structure for InterPro Entry

Q96MS3

UniProtKB/Swiss-Prot:

GL1D1_HUMAN :
  • Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
Family:
  • Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
genes like me logo Genes that share domains with GLT1D1: view

Function for GLT1D1 Gene

Enzyme Numbers (IUBMB) for GLT1D1 Gene

Gene Ontology (GO) - Molecular Function for GLT1D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with GLT1D1: view
genes like me logo Genes that share phenotypes with GLT1D1: view

Animal Model Products

No data available for Molecular function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GLT1D1 Gene

Localization for GLT1D1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLT1D1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GLT1D1 Gene COMPARTMENTS Subcellular localization image for GLT1D1 gene
Compartment Confidence
cytosol 3
extracellular 3

Gene Ontology (GO) - Cellular Components for GLT1D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with GLT1D1: view

Pathways & Interactions for GLT1D1 Gene

SuperPathways for GLT1D1 Gene

No Data Available

Interacting Proteins for GLT1D1 Gene

Gene Ontology (GO) - Biological Process for GLT1D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
GO:0009058 biosynthetic process --
genes like me logo Genes that share ontologies with GLT1D1: view

No data available for Pathways by source and SIGNOR curated interactions for GLT1D1 Gene

Drugs & Compounds for GLT1D1 Gene

No Compound Related Data Available

Transcripts for GLT1D1 Gene

Unigene Clusters for GLT1D1 Gene

Glycosyltransferase 1 domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GLT1D1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - -
SP2: - - - - -
SP3:

Relevant External Links for GLT1D1 Gene

GeneLoc Exon Structure for
GLT1D1
ECgene alternative splicing isoforms for
GLT1D1

Expression for GLT1D1 Gene

mRNA expression in normal human tissues for GLT1D1 Gene

mRNA differential expression in normal tissues according to GTEx for GLT1D1 Gene

This gene is overexpressed in Whole Blood (x26.7).

SOURCE GeneReport for Unigene cluster for GLT1D1 Gene Hs.655668

genes like me logo Genes that share expression patterns with GLT1D1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for GLT1D1 Gene

Orthologs for GLT1D1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GLT1D1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GLT1D1 35
  • 83.96 (n)
  • 85.34 (a)
GLT1D1 36
  • 66 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GLT1D1 35
  • 82.33 (n)
  • 86.09 (a)
GLT1D1 36
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Glt1d1 35
  • 80.58 (n)
  • 85.34 (a)
Glt1d1 16
Glt1d1 36
  • 66 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GLT1D1 35
  • 99.12 (n)
  • 99.25 (a)
GLT1D1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Glt1d1 35
  • 80.7 (n)
  • 84.21 (a)
oppossum
(Monodelphis domestica)
Mammalia GLT1D1 36
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GLT1D1 36
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves GLT1D1 35
  • 66.81 (n)
  • 65.69 (a)
GLT1D1 36
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GLT1D1 36
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia glt1d1 35
  • 64.36 (n)
  • 63.85 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.14935 35
LOC101884717 35
  • 60.32 (n)
  • 60.95 (a)
GLT1D1 36
  • 42 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 24 (a)
OneToOne
Species with no ortholog for GLT1D1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GLT1D1 Gene

ENSEMBL:
Gene Tree for GLT1D1 (if available)
TreeFam:
Gene Tree for GLT1D1 (if available)

Paralogs for GLT1D1 Gene

No data available for Paralogs for GLT1D1 Gene

Variants for GLT1D1 Gene

Sequence variations from dbSNP and Humsavar for GLT1D1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs470369 -- 128,974,835(-) AGCAG(C/T)CAACA intron-variant
rs470379 -- 128,974,198(-) CCCGA(C/T)TGCAT intron-variant
rs470381 -- 128,966,016(+) CTCCA(A/G)AAAGA intron-variant
rs470390 -- 128,966,522(+) CAACC(C/T)CCTCA intron-variant
rs470393 -- 128,972,745(-) tgcac(C/T)tttta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GLT1D1 Gene

Variant ID Type Subtype PubMed ID
dgv532e1 CNV Complex 17122850
nsv832549 CNV Loss 17160897
nsv899618 CNV Gain 21882294
nsv899620 CNV Gain 21882294
nsv899621 CNV Gain 21882294
nsv521048 CNV Loss 19592680
esv2678080 CNV Deletion 23128226
esv23767 CNV Loss 19812545
nsv516077 CNV Loss 19592680
nsv818936 CNV Loss 17921354
nsv899622 CNV Gain 21882294
nsv929 CNV Insertion 18451855
nsv899623 CNV Gain 21882294
nsv899624 CNV Gain 21882294
esv2667523 CNV Deletion 23128226
nsv826543 CNV Loss 20364138
esv2746675 CNV Deletion 23290073
esv2204782 CNV Deletion 18987734
nsv526688 CNV Gain 19592680
esv2746676 CNV Deletion 23290073

Variation tolerance for GLT1D1 Gene

Residual Variation Intolerance Score: 60.79% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.86; 48.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GLT1D1 Gene

HapMap Linkage Disequilibrium report
GLT1D1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLT1D1 Gene

Disorders for GLT1D1 Gene

Relevant External Links for GLT1D1

Genetic Association Database (GAD)
GLT1D1
Human Genome Epidemiology (HuGE) Navigator
GLT1D1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GLT1D1
genes like me logo Genes that share disorders with GLT1D1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GLT1D1 Gene

Publications for GLT1D1 Gene

  1. Heritability and genome-wide association analysis of renal sinus fat accumulation in the Framingham Heart Study. (PMID: 22044751) Foster M.C. … Fox C.S. (BMC Med. Genet. 2011) 67
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 67
  3. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 67
  4. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 67
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67

Products for GLT1D1 Gene

Sources for GLT1D1 Gene

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