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Aliases for GLT1D1 Gene

Aliases for GLT1D1 Gene

  • Glycosyltransferase 1 Domain Containing 1 2 3 5
  • EC 2.4.-.- 4

External Ids for GLT1D1 Gene

Previous GeneCards Identifiers for GLT1D1 Gene

  • GC12P127863
  • GC12P129337
  • GC12P126322

Summaries for GLT1D1 Gene

GeneCards Summary for GLT1D1 Gene

GLT1D1 (Glycosyltransferase 1 Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring glycosyl groups.

Additional gene information for GLT1D1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLT1D1 Gene

Genomics for GLT1D1 Gene

Regulatory Elements for GLT1D1 Gene

Enhancers for GLT1D1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H128808 2 FANTOM5 Ensembl ENCODE dbSUPER 71.3 -36.3 -36346 16 HDGF FOXA2 PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 GLT1D1 SLC15A4 PIR43248 ENSG00000279500
GH12H128855 1.6 FANTOM5 Ensembl ENCODE dbSUPER 78.6 +3.5 3499 2 HDGF SMARCA5 PKNOX1 TBL1XR1 ZBED1 NR2F1 EBF1 BATF ZNF217 POLR2A GLT1D1 SLC15A4 GC12M128836
GH12H128828 1.8 FANTOM5 Ensembl ENCODE dbSUPER 44.3 -23.1 -23076 2 HDGF PKNOX1 TBL1XR1 BMI1 BATF ATF7 ETV6 RUNX3 IKZF2 CREM GLT1D1 SLC15A4 ENSG00000274695 LOC101929984
GH12H128790 1.7 FANTOM5 Ensembl ENCODE dbSUPER 24.8 -58.2 -58167 8 HDGF PKNOX1 KLF17 BMI1 FEZF1 BATF ATF7 ETV6 CREM IKZF2 GLT1D1 SLC15A4 ENSG00000279500 GC12P128747
GH12H128806 1.2 FANTOM5 Ensembl ENCODE dbSUPER 24.8 -46.0 -45959 1 IKZF2 GLT1D1 ENSG00000279500 GC12P128747
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GLT1D1 on UCSC Golden Path with GeneCards custom track

Promoters for GLT1D1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000059234 273 601 SMARCA5 ZNF687 BACH1 EZH2

Transcription factor binding sites by QIAGEN in the GLT1D1 gene promoter:

Genomic Location for GLT1D1 Gene

Chromosome:
12
Start:
128,853,427 bp from pter
End:
128,984,968 bp from pter
Size:
131,542 bases
Orientation:
Plus strand

Genomic View for GLT1D1 Gene

Genes around GLT1D1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GLT1D1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GLT1D1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLT1D1 Gene

Proteins for GLT1D1 Gene

  • Protein details for GLT1D1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96MS3-GL1D1_HUMAN
    Recommended name:
    Glycosyltransferase 1 domain-containing protein 1
    Protein Accession:
    Q96MS3
    Secondary Accessions:
    • Q86XG8

    Protein attributes for GLT1D1 Gene

    Size:
    346 amino acids
    Molecular mass:
    38507 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GLT1D1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GLT1D1 Gene

Post-translational modifications for GLT1D1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for GLT1D1 Gene

Domains & Families for GLT1D1 Gene

Gene Families for GLT1D1 Gene

Protein Domains for GLT1D1 Gene

Suggested Antigen Peptide Sequences for GLT1D1 Gene

Graphical View of Domain Structure for InterPro Entry

Q96MS3

UniProtKB/Swiss-Prot:

GL1D1_HUMAN :
  • Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
Family:
  • Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
genes like me logo Genes that share domains with GLT1D1: view

Function for GLT1D1 Gene

Enzyme Numbers (IUBMB) for GLT1D1 Gene

Phenotypes From GWAS Catalog for GLT1D1 Gene

Gene Ontology (GO) - Molecular Function for GLT1D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016740 transferase activity IEA --
GO:0016757 NOT transferase activity, transferring glycosyl groups IBA --
genes like me logo Genes that share ontologies with GLT1D1: view
genes like me logo Genes that share phenotypes with GLT1D1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GLT1D1

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for GLT1D1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GLT1D1 Gene

Localization for GLT1D1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLT1D1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GLT1D1 gene
Compartment Confidence
cytosol 5
extracellular 3
mitochondrion 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for GLT1D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with GLT1D1: view

Pathways & Interactions for GLT1D1 Gene

SuperPathways for GLT1D1 Gene

No Data Available

Interacting Proteins for GLT1D1 Gene

Selected Interacting proteins: Q96MS3-GL1D1_HUMAN for GLT1D1 Gene via IID

Symbol External ID(s) Details
NPHP4

Gene Ontology (GO) - Biological Process for GLT1D1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GLT1D1 Gene

Drugs & Compounds for GLT1D1 Gene

No Compound Related Data Available

Transcripts for GLT1D1 Gene

Unigene Clusters for GLT1D1 Gene

Glycosyltransferase 1 domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for GLT1D1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for GLT1D1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - -
SP2: - - - - -
SP3:

Relevant External Links for GLT1D1 Gene

GeneLoc Exon Structure for
GLT1D1
ECgene alternative splicing isoforms for
GLT1D1

Expression for GLT1D1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GLT1D1 Gene

mRNA differential expression in normal tissues according to GTEx for GLT1D1 Gene

This gene is overexpressed in Whole Blood (x26.7).

NURSA nuclear receptor signaling pathways regulating expression of GLT1D1 Gene:

GLT1D1

SOURCE GeneReport for Unigene cluster for GLT1D1 Gene:

Hs.655668

Evidence on tissue expression from TISSUES for GLT1D1 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with GLT1D1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GLT1D1 Gene

Orthologs for GLT1D1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GLT1D1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GLT1D1 33 34
  • 99.12 (n)
cow
(Bos Taurus)
Mammalia GLT1D1 33 34
  • 83.96 (n)
dog
(Canis familiaris)
Mammalia GLT1D1 33 34
  • 82.33 (n)
rat
(Rattus norvegicus)
Mammalia Glt1d1 33
  • 80.7 (n)
mouse
(Mus musculus)
Mammalia Glt1d1 33 16 34
  • 80.58 (n)
oppossum
(Monodelphis domestica)
Mammalia GLT1D1 34
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GLT1D1 34
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves GLT1D1 33 34
  • 66.81 (n)
lizard
(Anolis carolinensis)
Reptilia GLT1D1 34
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia glt1d1 33
  • 64.36 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC101884717 33
  • 60.32 (n)
GLT1D1 34
  • 42 (a)
OneToOne
Dr.14935 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 24 (a)
OneToOne
Species where no ortholog for GLT1D1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GLT1D1 Gene

ENSEMBL:
Gene Tree for GLT1D1 (if available)
TreeFam:
Gene Tree for GLT1D1 (if available)

Paralogs for GLT1D1 Gene

No data available for Paralogs for GLT1D1 Gene

Variants for GLT1D1 Gene

Sequence variations from dbSNP and Humsavar for GLT1D1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000037063 -- 128,963,663(+) AGGTG(-/T)TTTTT intron-variant
rs1000044412 -- 128,927,592(+) AGTCA(A/C)TTTGC intron-variant
rs1000050327 -- 128,893,919(+) TGAAG(C/T)TTCCC intron-variant
rs1000092564 -- 128,926,855(+) GAGAC(C/T)AGTCC intron-variant
rs1000161111 -- 128,883,314(+) GGGCC(A/G)GGCGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GLT1D1 Gene

Variant ID Type Subtype PubMed ID
esv2204782 CNV deletion 18987734
esv23767 CNV loss 19812545
esv2667523 CNV deletion 23128226
esv2678080 CNV deletion 23128226
esv2746675 CNV deletion 23290073
esv2746676 CNV deletion 23290073
esv2759920 CNV loss 17122850
esv3549997 CNV deletion 23714750
esv3580535 CNV loss 25503493
esv3580536 CNV loss 25503493
esv3581993 CNV gain 25503493
esv3631151 CNV gain 21293372
esv3631153 CNV gain 21293372
esv3631154 CNV loss 21293372
esv3631155 CNV loss 21293372
esv3631156 CNV gain 21293372
esv3631157 CNV loss 21293372
nsv1040831 CNV gain 25217958
nsv1051433 CNV gain 25217958
nsv1069713 CNV deletion 25765185
nsv1070145 CNV deletion 25765185
nsv1118253 CNV deletion 24896259
nsv1134276 CNV deletion 24896259
nsv516077 CNV loss 19592680
nsv521048 CNV loss 19592680
nsv526688 CNV gain 19592680
nsv560689 CNV gain 21841781
nsv560690 CNV loss 21841781
nsv818936 CNV loss 17921354
nsv826543 CNV loss 20364138
nsv832549 CNV loss 17160897
nsv929 CNV insertion 18451855
nsv952505 CNV deletion 24416366
nsv973134 CNV duplication 23825009

Variation tolerance for GLT1D1 Gene

Residual Variation Intolerance Score: 60.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.86; 48.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GLT1D1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GLT1D1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLT1D1 Gene

Disorders for GLT1D1 Gene

Relevant External Links for GLT1D1

Genetic Association Database (GAD)
GLT1D1
Human Genome Epidemiology (HuGE) Navigator
GLT1D1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GLT1D1

No disorders were found for GLT1D1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GLT1D1 Gene

Publications for GLT1D1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. Heritability and genome-wide association analysis of renal sinus fat accumulation in the Framingham Heart Study. (PMID: 22044751) Foster MC … Fox CS (BMC medical genetics 2011) 3 60
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L … Andersson-Svahn H (Molecular & cellular proteomics : MCP 2008) 3 60

Products for GLT1D1 Gene

Sources for GLT1D1 Gene

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