Aliases for GLS Gene
External Ids for GLS Gene
Previous GeneCards Identifiers for GLS Gene
This gene encodes the K-type mitochondrial glutaminase. The encoded protein is an phosphate-activated amidohydrolase that catalyzes the hydrolysis of glutamine to glutamate and ammonia. This protein is primarily expressed in the brain and kidney plays an essential role in generating energy for metabolism, synthesizing the brain neurotransmitter glutamate and maintaining acid-base balance in the kidney. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
GeneCards Summary for GLS Gene
GLS (Glutaminase) is a Protein Coding gene. Diseases associated with GLS include spinocerebellar ataxia 2 and hepatic encephalopathy. Among its related pathways are MicroRNAs in cancer and Metabolism. GO annotations related to this gene include glutaminase activity. An important paralog of this gene is GLS2.
UniProtKB/Swiss-Prot for GLS Gene
Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. Isoform 2 lacks catalytic activity