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GLRX5 Gene

protein-coding   GIFtS: 54
GCID: GC14P096001

Glutaredoxin 5

(Previous names: chromosome 14 open reading frame 87, glutaredoxin 5 homolog...)
(Previous symbol: C14orf87)
  See GLRX5-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Glutaredoxin 51 2     Glutaredoxin 5 Homolog (S. Cerevisiae)1
C14orf871 2 3 5     GRX52
Monothiol Glutaredoxin-52 3     PR012382
FLB47392 5     Glutaredoxin 5 Homolog2
PRO12382 5     Glutaredoxin-Related Protein 5, Mitochondrial2
Chromosome 14 Open Reading Frame 871     

External Ids:    HGNC: 201341   Entrez Gene: 512182   Ensembl: ENSG000001825127   OMIM: 6095885   UniProtKB: Q86SX63   
ORGUL members:         

Export aliases for GLRX5 gene to outside databases

Previous GC identifers: GC14P095072 GC14P076186


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GLRX5 Gene:
This gene encodes a mitochondrial protein, which is evolutionarily conserved. It is involved in the biogenesis of
iron-sulfur clusters, which are required for normal iron homeostasis. Mutations in this gene are associated with
autosomal recessive pyridoxine-refractory sideroblastic anemia. (provided by RefSeq, May 2010)

GeneCards Summary for GLRX5 Gene:
GLRX5 (glutaredoxin 5) is a protein-coding gene. Diseases associated with GLRX5 include pearson syndrome, and spasticity-ataxia-gait anomalies syndrome. GO annotations related to this gene include electron carrier activity and 2 iron, 2 sulfur cluster binding.

UniProtKB/Swiss-Prot: GLRX5_HUMAN, Q86SX6
Function: Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Required for normal iron
homeostasis. Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1

Gene Wiki entry for GLRX5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the GLRX5 gene promoter:
         GR   Pax-5   AML1a   GR-beta   Nkx2-5   Nkx5-1   AREB6   POU2F1   POU2F1a   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGLRX5 promoter sequence
   Search Chromatin IP Primers for GLRX5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GLRX5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.13   Ensembl cytogenetic band:  14q32.13   HGNC cytogenetic band: 14q32.2

GLRX5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GLRX5 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P096001:  view genomic region     (about GC identifiers)

Start:
95,999,840 bp from pter      End:
96,011,061 bp from pter
Size:
11,222 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GLRX5_HUMAN, Q86SX6 (See protein sequence)
Recommended Name: Glutaredoxin-related protein 5, mitochondrial precursor  
Size: 157 amino acids; 16628 Da
Subunit: Homodimer (Probable)
Sequence caution: Sequence=CAD62364.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for GLRX5:
2WUL (3D)    
Secondary accessions: Q0X088 Q3YML0 Q86WY3 Q8IZ54

Explore the universe of human proteins at neXtProt for GLRX5: NX_Q86SX6

Explore proteomics data for GLRX5 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See GLRX5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057501.2  
    ENSEMBL proteins: 
     ENSP00000328570   ENSP00000451800  

    GLRX5 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for GLRX5

     
    Search eBioscience for Proteins for GLRX5 

    GLRX5 Antibody Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR002109 Glutaredoxin
     IPR012336 Thioredoxin-like_fold
     IPR004480 Monothiol_GRX-rel

    Graphical View of Domain Structure for InterPro Entry Q86SX6

    ProtoNet protein and cluster: Q86SX6

    1 Blocks protein domain: IPB002109 Glutaredoxin

    UniProtKB/Swiss-Prot: GLRX5_HUMAN, Q86SX6
    Similarity: Belongs to the glutaredoxin family. Monothiol subfamily
    Similarity: Contains 1 glutaredoxin domain


    Find genes that share domains with GLRX5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GLRX5_HUMAN, Q86SX6
    Function: Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Required for normal iron
    homeostasis. Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009055electron carrier activity IEA--
    GO:0015035protein disulfide oxidoreductase activity IEA--
    GO:0046872metal ion binding IEA--
    GO:00515372 iron, 2 sulfur cluster binding IEA--
         
    Find genes that share ontologies with GLRX5           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GLRX5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GLRX5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GLRX5
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    miRNA
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    miRTarBase miRNAs that target GLRX5:
    hsa-mir-18a-5p (MIRT050727), hsa-mir-222-3p (MIRT046660)

    Block miRNA regulation of human, mouse, rat GLRX5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GLRX5 (see all 11):
    hsa-miR-21* hsa-miR-140-5p hsa-miR-148b hsa-miR-627 hsa-miR-3120-3p hsa-miR-152 hsa-miR-582-5p hsa-miR-15b*
    SwitchGear 3'UTR luciferase reporter plasmidGLRX5 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat GLRX5

    Gene Editing
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    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GLRX5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GLRX5
    Addgene plasmids for GLRX5 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GLRX5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GLRX5_HUMAN, Q86SX6: Mitochondrion (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion4
    nucleus4
    cytosol3

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005739mitochondrion ISS--

    Find genes that share ontologies with GLRX5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for GLRX5
        Antioxidant Action of Vitamin-C


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GLRX5
    Interactions:

        Search GeneGlobe Interaction Network for GLRX5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GLRX5 (Q86SX63 ENSP000003285704) via UniProtKB, MINT, STRING, and/or I2D (see all 48)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HLA-BP304803, ENSP000003991684I2D: score=1 STRING: ENSP00000399168
    HDAC1Q135473, ENSP000003626494I2D: score=3 STRING: ENSP00000362649
    GLRX3O760033, ENSP000003308364I2D: score=1 STRING: ENSP00000330836
    PIK3R4Q995703, ENSP000003492054I2D: score=1 STRING: ENSP00000349205
    HSP90AA1P079003I2D: score=3 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030097hemopoiesis ISS--
    GO:0045454cell redox homeostasis IEA--

    Find genes that share ontologies with GLRX5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GLRX5



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GLRX5 gene: 
    NM_016417.2  

    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000553672 ENST00000331334(uc001yem.1) ENST00000557731
    miRNA
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    Block miRNA regulation of human, mouse, rat GLRX5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GLRX5 (see all 11):
    hsa-miR-21* hsa-miR-140-5p hsa-miR-148b hsa-miR-627 hsa-miR-3120-3p hsa-miR-152 hsa-miR-582-5p hsa-miR-15b*
    SwitchGear 3'UTR luciferase reporter plasmidGLRX5 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat GLRX5
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    GenScript: all cDNA clones in your preferred vector: GLRX5 (NM_016417)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GLRX5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GLRX5
    Addgene plasmids for GLRX5 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for GLRX5
    OriGene qSTAR qPCR primer pairs in human, mouse for GLRX5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GLRX5
      QuantiTect SYBR Green Assays in human, mouse, rat GLRX5
      QuantiFast Probe-based Assays in human, mouse, rat GLRX5

    Selected AceView cDNA sequences (see all 155):

    T92599 NM_016417 BX248075 BI259789 AA335842 CR598908 H90725 BX116512 
    AA694246 W80609 AI051722 CR622540 BM069826 BM682092 T72567 BM797827 
    AI263007 AW069332 BX346713 N90549 BX395035 BE562779 BX371178 AA203566 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GLRX5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGAGTTGA
    GLRX5 Expression
    About this image


    GLRX5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    GLRX5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GLRX5 Protein Expression
        Custom PCR Arrays for GLRX5
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GLRX5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for GLRX5 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Glrx51 , 5 glutaredoxin 5 homolog (S. cerevisiae)1, 5 88.6(n)1
    92.76(a)1
      12 (55.04 cM)5
    730461  NM_028419.21  NP_082695.11 
     1050326895 
    chicken
    (Gallus gallus)
    Aves GLRX51 glutaredoxin 5 76.23(n)
    79.13(a)
      423440  NM_001008472.1  NP_001008472.1 
    lizard
    (Anolis carolinensis)
    Reptilia GLRX56
    glutaredoxin 5
    68(a)
    1 ↔ 1
    6(53488724-53496206)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia glrx51 glutaredoxin 5 75.07(n)
    81.74(a)
      448300  NM_001004919.1  NP_001004919.1 
    zebrafish
    (Danio rerio)
    Actinopterygii glrx51 glutaredoxin 5 homolog (S. cerevisiae) 76.88(n)
    77.48(a)
      406294  NM_213021.1  NP_998186.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG144071 CG14407 70.54(n)
    69.64(a)
      32410  NM_132746.2  NP_572974.1 
    worm
    (Caenorhabditis elegans)
    Secernentea glrx-51 glrx-5 54.9(n)
    54.9(a)
      176662  NM_067209.6  NP_499610.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GRX5(YPL059W)4
    GRX51
    Hydroperoxide and superoxide-radical responsive glutathione-dependent more4
    GRX51
    54.37(n)1
    51.46(a)1
      16(444579-445031)4
    8560481, 4  NP_015266.11, 4 


    ENSEMBL Gene Tree for GLRX5 (if available)
    TreeFam Gene Tree for GLRX5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GLRX5 gene
    1 SIMAP similar gene for GLRX5 using alignment to 3 protein entries:     GLRX5_HUMAN (see all proteins):
    GLRX

    Find genes that share paralogs with GLRX5           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for GLRX5
    PGOHUM00000247778 PGOHUM00000245044 PGOHUM00000241973


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GLRX5 (see all 293)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1136322371,2
    C--76191885(+) TATATA/TTATTT 1 -- int10--------
    rs1434315341,2
    C--76191885(+) TATAT-/ATATTT 1 -- int10--------
    rs1125354001,2
    C--76191887(+) TATATA/TTTTTT 1 -- int10--------
    rs1511276231,2
    C--76191887(+) TATAT-/ATTTTT 1 -- int10--------
    rs352065351,2
    C--76191897(+) TTTTT-/T/TTTT
            
    GAGAG
    1 -- int11NA 2
    rs339347901,2
    C--76195331(+) AAATT-/A/AA  
            
    AAAAA
    1 -- int11CSA 2
    rs37423391,2
    C,F,A,H--76990046(-) AAGAAT/CCTTTT 1 -- us2k121Minor allele frequency- C:0.46EA NS NA WA 3816
    rs1402876561,2
    C--76990055(+) TTTAAG/TCACCT 1 -- us2k10--------
    rs1452473991,2
    --76990062(+) ACCTGA/GTAAAT 1 -- us2k10--------
    rs1479706341,2
    C--76990110(+) ATATTC/GATGGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for GLRX5 (95999840 - 96011061 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for GLRX5:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2749054CNV Deletion23290073
    dgv89e55CNV Gain17911159

    Human Gene Mutation Database (HGMD): GLRX5
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GLRX5
    DNA2.0 Custom Variant and Variant Library Synthesis for GLRX5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609588   
    OMIM disorders: 205950  
    UniProtKB/Swiss-Prot: GLRX5_HUMAN, Q86SX6
  • Anemia, sideroblastic, pyridoxine-refractory, autosomal recessive (PRARSA) [MIM:205950]: A form of
    sideroblastic anemia not responsive to pyridoxine. Sideroblastic anemia is characterized by anemia of varying
    severity, hypochromic peripheral erythrocytes, systemic iron overload secondary to chronic ineffective
    erythropoiesis, and the presence of bone marrow ringed sideroblasts. Sideroblasts are characterized by
    iron-loaded mitochondria clustered around the nucleus. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • 5 diseases for GLRX5:    
    About MalaCards
    pearson syndrome    spasticity-ataxia-gait anomalies syndrome    aspartylglucosaminuria    pyridoxine-refractory autosomal recessive sideroblastic anemia
    sideroblastic anemia

    2 diseases from the University of Copenhagen DISEASES database for GLRX5:
    Sideroblastic anemia     Pearson syndrome

    Find genes that share disorders with GLRX5           About GenesLikeMe

    Genetic Association Database (GAD): GLRX5
    Human Genome Epidemiology (HuGE) Navigator: GLRX5 (2 documents)

    Export disorders for GLRX5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GLRX5 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with GLRX5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human counterpart of zebrafish shiraz shows sideroblastic-like microcytic anemia and iron overload. (PubMed id 17485548)1, 2, 9 Camaschella C.... Iolascon A. (Blood 2007)
    2. The crystal structure of human GLRX5: iron-sulfur cluster co- ordination, tetrameric assembly and monomer activity. (PubMed id 21029046)1, 2 Johansson C....Kavanagh K.L. (Biochem. J. 2011)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    5. Deficiency of glutaredoxin 5 reveals Fe-S clusters are required for vertebrate haem synthesis. (PubMed id 16110529)1, 2 Wingert R.A....Zon L.I. (Nature 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Glutaredoxin 5 deficiency causes sideroblastic anemia by specifically impairing heme biosynthesis and depleting cytosolic iron in human erythroblasts. (PubMed id 20364084)1, 9 Ye H....Rouault T.A. (J. Clin. Invest. 2010)
    8. Systematic molecular genetic analysis of congenital sideroblastic anemia: evidence for genetic heterogeneity and identification of novel mutations. (PubMed id 19731322)1, 9 Bergmann A.K....Neufeld E.J. (amp 2010)
    9. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51218 HGNC: 20134 AceView: C14orf87 Ensembl:ENSG00000182512 euGenes: HUgn51218
    ECgene: GLRX5 H-InvDB: GLRX5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GLRX5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GLRX5 gene:
    Search GeneIP for patents involving GLRX5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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