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GLRX5 Gene

protein-coding   GIFtS: 49

GC14P095072
glutaredoxin 5
(Previous names: chromosome 14 open reading frame 87, glutaredoxin 5 homolog (S. cerevisiae) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: C14orf87)
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Aliases &
Descriptions
for GLRX5

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
C14orf87 2, 3, 5
FLB4739 2, 5
GRX5 1, 2
MGC14129 2
PR01238 1, 2
PRO1238 2, 5
Descriptions
chromosome 14 open reading frame 87 1
glutaredoxin 5 2
glutaredoxin 5 homolog 2
glutaredoxin 5 homolog (S. cerevisiae) 1
External Ids
HGNC: 201341
Entrez Gene: 512182
UniProtKB: Q86SX63
Ensembl: ENSG000001825127
Search outside databases for aliases for GLRX5 gene

Summaries
for GLRX5

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

   --

Genomic Location
for GLRX5

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the GLRX5 gene  

Entrez Gene cytogenetic band: 14q32.13   Ensembl cytogenetic band:  14q32.13   HGNC cytogenetic band: 14q32.2

GLRX5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P095072:     (about GC identifiers)

Start:
 95,071,076 bp from pter
End:
 95,080,808 bp from pter
Size:
 9,733 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000014.7  NT_026437.11  

Proteins
for GLRX5

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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 UniProtKB/Swiss-Prot: GLRX5_HUMAN, Q86SX6 (See protein sequence)
Recommended Name: Glutaredoxin-related protein 5  
Size: 157 amino acids; 16628 Da
Secondary accessions: Q3YML0 Q86WY3 Q8IZ54

REFSEQ proteins: NP_057501.2  

ENSEMBL proteins: 
ENSP00000328570 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse Abcam for Recombinant Proteins
Human Recombinant Proteins from Abnova (GLRX5)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

1 Gene Ontology (GO) cellular component term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005739 mitochondrion ISS--
About this table

Antibodies for GLRX5: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for GLRX5

Assays for GLRX5: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

Protein Domains/
Families
for GLRX5

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
3 InterPro domains/families:
 IPR002109 Glutaredoxin
 IPR012335 Thioredoxin_fold
 IPR004480 Glutredox-rel


   GeneDecks  GLRX5 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q86SX6

ProtoNet protein and cluster: Q86SX6

1 Blocks protein family: IPB002109 Glutaredoxin

UniProtKB/Swiss-Prot: GLRX5_HUMAN, Q86SX6
Similarity: Belongs to the glutaredoxin family. Monothiol subfamily
Similarity: Contains 1 glutaredoxin domain

Gene Function
for GLRX5

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (GLRX5)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_016417

              Applied Biosystems Silencer® siRNAs for GLRX5

              Sigma-Aldrich siRNA for GLRX5  
                     Browse shRNA at Sigma-Aldrich  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for GLRX5
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_016417
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_016417
                                 untagged cDNA clone in CMV expression vector: NM_016417 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_016417

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0009055 electron carrier activity IEA--
GO:0015035 protein disulfide oxidoreductase activity IEA--
About this table

Pathways & Interactions
for GLRX5

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section



5/7 Interacting proteins for GLRX5 (ENSP000003285703) via UniProtKB, MINT, and/or STRING (see all 7 )
InteractantInteraction Details
GeneCardExternal ID(s)
GLRX2ENSP000003564103STRING (score=.896)
ALAS2ENSP000003323693STRING (score=.877)
ACO1ENSP000003094773STRING (score=.828)
NFU1ENSP000003069653STRING (score=.772)
TXNENSP000003636413STRING (score=.716)
About this table

1 Gene Ontology (GO) biological process term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0045454 cell redox homeostasis IEA--
About this table

Drugs & Compounds
for GLRX5

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for GLRX5

Transcripts
for GLRX5

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (GLRX5)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_016417

              Sigma-Aldrich siRNA for GLRX5  
                     Browse shRNA at Sigma-Aldrich  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_016417  

REFSEQ mRNAs for GLRX5 gene: 

NM_016417.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_016417  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_016417
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_016417
                                 untagged cDNA clone in CMV expression vector: NM_016417 

Additional cDNA sequence: 

AB223038.1 AF113691.1 BC023528.2 BC047680.1 BC071690.1 BC105275.1 BX248075.1 CR936698.1 
DQ083331.1 

7 DOTS entries:

DT.115000  DT.428883  DT.95170065  DT.91727762  DT.95170067  DT.99929797  DT.86849096 

24/155 AceView cDNA sequences (see all 155 ):

AA335842 CR598908 AA694246 BX248075 H90725 CR622540 W80609 AI051722 
NM_016417 BI259789 BX116512 T92599 BQ231243 BI091398 BG911441 T72567 
BI599990 AW069332 BC023528 BQ435345 BG519612 BM976952 BM682092 AA875867 

highest scoring ESTs for GLRX5:

AI973147 N36909 AA133341 AA133382 AA203566 AA314626 AA482495 AA482645 AA644458 AA677563 

Unigene Cluster for GLRX5:

Glutaredoxin 5
Hs.719204  [show with all ESTs]
Unigene Representative Sequence: CR936698


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:
ENST00000331334  

Expression
for GLRX5

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

GLRX5 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for GLRX5

1 / 2 / 3

4 probe-sets matching GLRX5 gene


Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

65171_at2, 3 U95-C 1 1.00 1.00 1.00 1.00 N36909 1.00 1.00 1.00 1

59721_at2, 3 U95-C 1 0.94 1.00 0.99 1.00 AI973147 1.00 1.00 1.00 1

221932_s_at2, 3 U133-A 2 1.00 0.95 -- -- AA133341 0.80 1.00 0.91 1

221932_s_at2 U133Plus2 2 1.00 0.95 -- -- -- -- -- -- --
About this table
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.719204

Orthologs
for GLRX5

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for GLRX5 gene from 5/17 species (see all 17 )
Organism Gene Locus Description Human
Similarity		 NCBI accessions
chimpanzee
(Pan troglodytes)		 GLRX51   -- glutaredoxin 5 99.79(n)
100(a)		 741187  XM_001154482.1  XP_001154482.1 
cow
(Bos taurus)		 GLRX51   -- glutaredoxin 5 92.21(n)
94.81(a)		 505935  XM_582303.3  XP_582303.1 
rat
(Rattus norvegicus)		 Glrx51   -- glutaredoxin 5 89.91(n)
92.76(a)		 362776  XM_343103.3  XP_343104.3 
mouse
(Mus musculus)		 Glrx51, 5 125
 glutaredoxin 5 homolog (S. cerevisiae)1, 5 89.69(n)1
94.08(a)1		 730461  NM_028419.21  NP_082695.11 
 AK0137615  AK1488475  (see all 10)
chicken
(Gallus gallus)		 GLRX51   -- glutaredoxin 5 71.71(n)
73.68(a)		 423440  NM_001008472.1  NP_001008472.1 
About this table        Species with no ortholog for GLRX5

ENSEMBL Gene Tree for GLRX5

Paralogs
for GLRX5

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for GLRX5 gene
GLRX32  

SNPs/Variants
for GLRX5

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/103 NCBI SNPs in GLRX5 are shown (see all 103 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 98)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 14 posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
------------
rs7497421,2
A,C,F,H95069751(+) TTCCGG/CATTTA 1 -- ng515Minor allele frequency- C:0.08MN EU EA WA 602
rs37423391,2
A,C,F,H95069167(-) AAGAAT/CCTTTT 1 -- ng515Minor allele frequency- C:0.48EA EU WA 1906
rs38255461,2
A,C,F,H95069573(-) TGGTCA/GCTGTT 1 -- ng518Minor allele frequency- G:0.43EU EA WA 824
rs71201,2
C,F,H95080342(+) GGTTCG/ATGAGC 1 -- ut31 ese314Minor allele frequency- A:0.38MN EA NA EU WA 2584
rs9116811,2
A,C,F95071136(+) TGGCCA/CGCTGT 1 -- ut51 ese31Minor allele frequency- C:0.31MN 184
rs23690161,2
C,F,O95081128(+) CATGAG/TTTCTG 1 -- ng314Minor allele frequency- N:0.03EA NA 216
rs22363151,2
C,F,H95080914(+) GAGGCC/TGGAGG 1 -- ng315Minor allele frequency- T:0.33EA EU WA 1904
rs125864861,2
C,F95081288(+) GGAAGA/GAGGAT 1 -- ng313Minor allele frequency- G:0.29NA 142
rs22363141,2
C,F95080682(+) GGGATG/ACTGTG 1 -- ut31 ese33Minor allele frequency- A:0.21EA NA 1494
rs125864841,2
C,F95081260(+) GAAACA/TTATCT 1 -- ng313Minor allele frequency- T:0.29NA 142
About this table

HapMap Linkage Disequilibrium images for GLRX5 (up to first 250kb)

Disorders & Mutations
for GLRX5

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

 OMIM: 609588   disorders: 205950  

UniProtKB/Swiss-Prot: GLRX5_HUMAN, Q86SX6

  • Defects in GLRX5 are the cause of anemia sideroblastic pyridoxine-refractory autosomal
    recessive (PRARSA) [MIM:205950]. Sideroblastic anemia is characterized by anemia of varying
    severity, hypochromic peripheral erythrocytes, systemic iron overload secondary to chronic
    ineffective erythropoiesis, and the presence of bone marrow ringed sideroblasts. Sideroblasts are
    characterized by iron-loaded mitochondria clustered around the nucleus. PRARSA is not responsive
    to pyridoxine

    • Human Gene Mutation Database: GLRX5

    Medical News
    for GLRX5

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for GLRX5

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		6 PubMed articles for GLRX5 gene:

    Search for GLRX5

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing GLRX5

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 51218 HGNC: 20134 AceView: C14orf87 Ensembl:ENSG00000182512 euGenes: HUgn51218
    ECgene: GLRX5 H-InvDB: GLRX5

    Other Databases showing GLRX5

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing GLRX5

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    		   --

    Licensable Technologies
    for GLRX5

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for GLRX5

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for GLRX5:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



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     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for GLRX5 Browse antibodies at Sigma-Aldrich
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Browse shRNAs at Sigma-Aldrich Browse small molecules at Sigma-Aldrich
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     Search Novus for antibodies for GLRX5

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