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GLRX3 Gene

protein-coding   GIFtS: 59
GCID: GC10P131934

Glutaredoxin 3

(Previous name: thioredoxin-like 2)
(Previous symbol: TXNL2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Glutaredoxin 31 2     PKCq-Interacting Protein2 3
TXNL21 2 3     Thioredoxin-Like 21
PICOT2 3 5     GLRX42
Glutaredoxin 41 2     GRX32
Thioredoxin-Like Protein 22 3     GRX42
PKC-Interacting Cousin Of Thioredoxin2 3     TXNL32
PKC-Theta-Interacting Protein2 3     glutaredoxin-32

External Ids:    HGNC: 159871   Entrez Gene: 105392   Ensembl: ENSG000001080107   OMIM: 6127545   UniProtKB: O760033   

Export aliases for GLRX3 gene to outside databases

Previous GC identifers: GC10P131826 GC10P125514


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GLRX3 Gene:
This gene encodes a member of the glutaredoxin family. Glutaredoxins are oxidoreductase enzymes that reduce a
variety of substrates using glutathione as a cofactor. The encoded protein binds to and modulates the function of
protein kinase C theta. The encoded protein may also inhibit apoptosis and play a role in cellular growth, and
the expression of this gene may be a marker for cancer. Pseudogenes of this gene are located on the short arm of
chromosomes 6 and 9. Alternatively spliced transcript variants have been observed for this gene. (provided by
RefSeq, Dec 2010)

GeneCards Summary for GLRX3 Gene:
GLRX3 (glutaredoxin 3) is a protein-coding gene. Diseases associated with GLRX3 include lymphocytic choriomeningitis, and hodgkin's lymphoma. GO annotations related to this gene include electron carrier activity and protein disulfide oxidoreductase activity.

UniProtKB/Swiss-Prot: GLRX3_HUMAN, O76003
Function: Critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity).
May play a role in regulating the function of the thioredoxin system. Does not posses any thyoredoxin activity
since it lacks the conserved motif that is essential for catalytic activity

Gene Wiki entry for GLRX3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the GLRX3 gene promoter:
         SRF   AhR   NRSF form 1   SRF (504 AA)   POU6F1 (c2)   Nkx2-5   NRSF form 2   Arnt   ZIC2/Zic2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGLRX3 promoter sequence
   Search Chromatin IP Primers for GLRX3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GLRX3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26   Ensembl cytogenetic band:  10q26.3   HGNC cytogenetic band: 10q26

GLRX3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GLRX3 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P131934:  view genomic region     (about GC identifiers)

Start:
131,934,639 bp from pter      End:
131,982,785 bp from pter
Size:
48,147 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GLRX3_HUMAN, O76003 (See protein sequence)
Recommended Name: Glutaredoxin-3  
Size: 335 amino acids; 37432 Da
Subunit: Monomer and homodimer; the homodimer is probably linked by 2 2Fe-2S clusters that may serve as a redox
sensor. The monomer interacts with other proteins. Interacts (via N-terminus) with PRKCQ/PKC-theta. Interacts
(via C-terminus) with CSRP3 (By similarity). Interacts with CSRP2 (By similarity)
4 PDB 3D structures from and Proteopedia for GLRX3:
2DIY (3D)        2WZ9 (3D)        2YAN (3D)        3ZYW (3D)    
Secondary accessions: B3KMP7 B3KMQ5 D3DRG2 Q5JV01 Q96CE0 Q9P1B0 Q9P1B1

Explore the universe of human proteins at neXtProt for GLRX3: NX_O76003

Explore proteomics data for GLRX3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys240
  • Modification sites at PhosphoSitePlus

  • See GLRX3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001186797.1  NP_006532.2  

    ENSEMBL proteins: 
     ENSP00000330836   ENSP00000357633   ENSP00000435445  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR002109 Glutaredoxin
     IPR012336 Thioredoxin-like_fold
     IPR004480 Monothiol_GRX-rel
     IPR013766 Thioredoxin_domain

    Graphical View of Domain Structure for InterPro Entry O76003

    ProtoNet protein and cluster: O76003

    2 Blocks protein domains:
    IPB002109 Glutaredoxin
    IPB006662 Thioredoxin type domain


    UniProtKB/Swiss-Prot: GLRX3_HUMAN, O76003
    Domain: The thioredoxin domain lacks the two redox-active cysteines. This strongly suggests that it lacks
    thioredoxin activity
    Similarity: Contains 2 glutaredoxin domains
    Similarity: Contains 1 thioredoxin domain


    GLRX3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GLRX3_HUMAN, O76003
    Function: Critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity).
    May play a role in regulating the function of the thioredoxin system. Does not posses any thyoredoxin activity
    since it lacks the conserved motif that is essential for catalytic activity

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005080protein kinase C binding IEA--
    GO:0005515protein binding IPI10636891
    GO:0009055electron carrier activity IEA--
    GO:0015035protein disulfide oxidoreductase activity IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    GLRX3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for GLRX3:
     Decreased viability of wild-ty 

         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Glrx3):
     cardiovascular system  cellular  embryogenesis  growth/size/body  homeostasis/metabolism 
     mortality/aging  muscle  nervous system 

    GLRX3 for phenotypes           About GeneDecksing

    Animal Models:
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    hsa-mir-30a-5p (MIRT028654)

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    SwitchGear 3'UTR luciferase reporter plasmidGLRX3 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GLRX3_HUMAN, O76003: Cytoplasm, cell cortex. Cytoplasm, myofibril, sarcomere, Z line (By similarity). Note=Under
    the plasma membrane. After PMA stimulation, GLRX3 and PRKCQ/PKC-theta translocate to a more extended submembrane
    area. In the Z line, found associated with CSRP3 (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    endoplasmic reticulum1
    extracellular1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005681spliceosomal complex ----
    GO:0005938cell cortex IEA--
    GO:0030018Z disc IEA--

    GLRX3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GLRX3
    Interactions:

        Search GeneGlobe Interaction Network for GLRX3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GLRX3 (O760031, 2, 3 ENSP000003308364) via UniProtKB, MINT, STRING, and/or I2D (see all 117)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CIAPIN1Q6FI811, 2, 3, ENSP000003779144EBI-374781,EBI-750511 MINT-67821 I2D: score=6 STRING: ENSP00000377914
    EFEMP2O959672, 3, ENSP000003099534MINT-67284 I2D: score=4 STRING: ENSP00000309953
    FRA10AC1Q70Z532, 3, ENSP000003604884MINT-64736 I2D: score=4 STRING: ENSP00000360488
    PRKCQQ047591, 3, ENSP000002631254EBI-374781,EBI-374762 I2D: score=4 STRING: ENSP00000263125
    HEXDCQ8WVB32, 3MINT-65043 I2D: score=5 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002026regulation of the force of heart contraction ISS--
    GO:0007067mitosis ----
    GO:0010614negative regulation of cardiac muscle hypertrophy ISS--
    GO:0045454cell redox homeostasis IEA--

    GLRX3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GLRX3

    3 Novoseek inferred chemical compound relationships for GLRX3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dithiol 55.5 1 1778302 (1)
    cyanogen bromide 43.2 1 8119877 (1)
    calcium 0 1 15050380 (1)



    GLRX3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for GLRX3 gene (2 alternative transcripts): 
    NM_001199868.1  NM_006541.4  

    Unigene Cluster for GLRX3:

    Glutaredoxin 3
    Hs.42644  [show with all ESTs]
    Unigene Representative Sequence: NM_001199868
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000331244(uc001lkm.2 uc021qay.1) ENST00000368644(uc001lkn.2)
    ENST00000481034(uc001lko.3) ENST00000486974 ENST00000496195
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    hsa-miR-137 hsa-miR-3611 hsa-miR-1224-5p
    SwitchGear 3'UTR luciferase reporter plasmidGLRX3 3' UTR sequence
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    Additional mRNA sequence: 

    AF118649.1 AF118652.1 AK022131.1 AK225609.1 BC005289.1 BC014372.1 

    15 DOTS entries:

    DT.118290  DT.100788931  DT.100788929  DT.100764688  DT.65285361  DT.121267145  DT.100700023  DT.121332565 
    DT.95306744  DT.121267152  DT.40112243  DT.95238354  DT.100044571  DT.70101531  DT.95238366 

    Selected AceView cDNA sequences (see all 371):

    CA432473 BG251536 AI755205 BI256922 BI823919 BG201743 AI151433 BU187566 
    AW273006 Z40527 CA308812 AI628153 BF059487 BM712152 BF435468 AW026315 
    BQ954190 W49685 AI674397 BX282433 CA413447 CR602310 AA777016 CR625572 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for GLRX3    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
    SP1:                                      -           -                                                               
    SP2:                                                                                                                  
    SP3:              -                       -           -                                                               
    SP4:              -                                                                                                   
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for GLRX3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GLRX3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    GLRX3 Expression
    About this image


    GLRX3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Primary Oocyte Primary Follicle
             Oviduct
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Gonad
             Primary Oocyte Primary Follicle
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Heart (Cardiovascular System)
             Atrioventricular Node
    GLRX3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GLRX3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.42644

    UniProtKB/Swiss-Prot: GLRX3_HUMAN, O76003
    Tissue specificity: Expressed in heart, spleen, testis and, to a lower extent, in thymus and peripheral blood
    leukocytes. Weakly expressed in lung, placenta, colon and small intestine

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GLRX3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for GLRX3 gene from Selected species (see all 27)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Glrx31 , 5 glutaredoxin 31, 5 90.46(n)1
    93.4(a)1
      7 (82.32 cM)5
    309261  NM_023140.41  NP_075629.21 
     1374376485 
    chicken
    (Gallus gallus)
    Aves GLRX31 glutaredoxin 3 79.04(n)
    83.33(a)
      423968  NM_001277384.1  NP_001264313.1 
    lizard
    (Anolis carolinensis)
    Reptilia GLRX36
    glutaredoxin 3
    77(a)
    1 ↔ 1
    3(56059120-56089352)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.92032 Xenopus laevis transcribed sequence with moderate similarity more 73.37(n)    BU901136.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb38e092 Transcribed sequence with weak similarity to protein more 75.32(n)    CK240060.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG65236
    --
    45(a)
    1 ↔ 1
    2L(13366466-13367410)
    worm
    (Caenorhabditis elegans)
    Secernentea glrx-31 glrx-3 57.27(n)
    52.92(a)
      178828  NM_001028585.3  NP_001023756.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GRX4(YER174C)4
    GRX41
    Hydroperoxide and superoxide-radical responsive glutathione-dependent more4
    GRX41
    52.33(n)1
    46.5(a)1
      5(539168-538434)4
    8569211, 4  NP_011101.31  NP_011101.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G049501 AT4G04950 58.5(n)
    52.68(a)
      825835  NM_116733.3  NP_192404.1 
    rice
    (Oryza sativa)
    Liliopsida Os.115762 Oryza sativa (japonica cultivar-group) cDNA clone0 more 77.04(n)    AK059628.1 


    ENSEMBL Gene Tree for GLRX3 (if available)
    TreeFam Gene Tree for GLRX3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GLRX3 gene

    GLRX3 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for GLRX3
    PGOHUM00000243473 PGOHUM00000235984


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GLRX3 (see all 1016)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs74765361,2
    C,A--125517815(+) AAAAAA/CCAAAA 2 -- int14Minor allele frequency- C:0.12NA WA 8
    rs2001650911,2
    C--125517815(+) AAAAA-/CCAAAA 2 -- int10--------
    rs32157921,2
    C--125553372(-) TAGAAA/-TGTCT 2 -- int11Minor allele frequency- -:0.00NA 2
    rs38349081,2
    C--131933678(+) GCACC-/CTGT  
            
    CTGTG
    2 -- us2k10--------
    rs789819581,2
    C--131944365(+) TACAC-/TTTTCC 2 -- int10--------
    rs576341031,2
    C--131947717(+) AAAAA-/A/AA  
            
    CAAAA
    2 -- int11NA 2
    rs675390091,2
    C--131948041(+) TTTTT-/TGGTCT 2 -- int10--------
    rs618744031,2
    C--131949879(+) GAACAC/TGTGGT 2 -- int10--------
    rs1113232561,2
    F--131951467(+) CTAACT/ATTTTT 2 -- int11Minor allele frequency- A:0.50CSA 2
    rs763720951,2
    C--131951519(-) TCCAAA/GCTAAA 2 -- int10--------

    HapMap Linkage Disequilibrium report for GLRX3 (131934639 - 131982785 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for GLRX3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832024CNV Loss17160897
    nsv825630CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GLRX3
    DNA2.0 Custom Variant and Variant Library Synthesis for GLRX3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612754    OMIM disorders: --

    8 diseases for GLRX3:    
    About MalaCards
    lymphocytic choriomeningitis    hodgkin's lymphoma    tonsillitis    alzheimer's disease
    colorectal cancer    hiv-1    thyroiditis    cerebritis

    1 disease from the University of Copenhagen DISEASES database for GLRX3:
    Lymphocytic choriomeningitis

    GLRX3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): GLRX3
    Human Genome Epidemiology (HuGE) Navigator: GLRX3 (2 documents)

    Export disorders for GLRX3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GLRX3 gene, integrated from 10 sources (see all 107):
    (articles sorted by number of sources associating them with GLRX3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of 16 novel human genes showing high similarity to yeast sequences. (PubMed id 11124703)1, 2, 3 Stanchi F.... Valle G. (Yeast 2001)
    2. Inhibition of the c-Jun N-terminal kinase/AP-1 and NF-kappaB pathways by PICOT, a novel protein kinase C-interacting protein with a thioredoxin homology domain. (PubMed id 10636891)1, 2, 3 Witte S.... Altman A. (J. Biol. Chem. 2000)
    3. Common human genetic variants and HIV-1 susceptibility: a genome-wide survey in a homogeneous African population. (PubMed id 21160409)1, 4 Petrovski S....Goldstein D.B. (AIDS 2011)
    4. Characterization of the human monothiol glutaredoxin 3 (PICOT) as iron-sulfur protein. (PubMed id 20226171)1, 2 Haunhorst P.... Lillig C.H. (Biochem. Biophys. Res. Commun. 2010)
    5. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    6. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Preferential overexpression of glutaredoxin3 in human colon and lung carcinoma. (PubMed id 19797004)1, 9 Cha M.K. and Kim I.H. (Cancer Epidemiol 2009)
    10. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10539 HGNC: 15987 AceView: TXNL2 Ensembl:ENSG00000108010 euGenes: HUgn10539
    ECgene: GLRX3 H-InvDB: GLRX3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GLRX3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GLRX3 gene:
    Search GeneIP for patents involving GLRX3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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