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GLRX Gene

protein-coding   GIFtS: 66
GCID: GC05M095087

Glutaredoxin (Thioltransferase)

  See GLRX-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Glutaredoxin (Thioltransferase)1 2     glutaredoxin-12
GRX2 3 5     thioltransferase-12
TTase-12 3     Thioltransferase-13
GRX12     

External Ids:    HGNC: 43301   Entrez Gene: 27452   Ensembl: ENSG000001732217   OMIM: 6004435   UniProtKB: P357543   

Export aliases for GLRX gene to outside databases

Previous GC identifers: GC05M094407 GC05M095614 GC05M095178 GC05M095223 GC05M095175 GC05M090339


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GLRX Gene:
This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the
reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant
defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of
signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer's disease. Multiple alternatively
spliced transcript variants encoding the same protein have been identified. (provided by RefSeq, Aug 2011)

GeneCards Summary for GLRX Gene:
GLRX (glutaredoxin (thioltransferase)) is a protein-coding gene. Diseases associated with GLRX include pancreatic cystadenocarcinoma, and transitional meningioma. GO annotations related to this gene include electron carrier activity and protein disulfide oxidoreductase activity. An important paralog of this gene is GLRX2.

UniProtKB/Swiss-Prot: GLRX1_HUMAN, P35754
Function: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase.
Reduces low molecular weight disulfides and proteins

Gene Wiki entry for GLRX Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_034772.7  
Regulatory elements:
   Regulatory transcription factor binding sites in the GLRX gene promoter:
         GR   AP-1   ATF-2   Egr-2   AREB6   Pax-2b   POU2F1   POU2F1a   GR-alpha   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGLRX promoter sequence
   Search Chromatin IP Primers for GLRX

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GLRX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q14   Ensembl cytogenetic band:  5q15   HGNC cytogenetic band: 5q14

GLRX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GLRX gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M095087:  view genomic region     (about GC identifiers)

Start:
95,087,023 bp from pter      End:
95,158,709 bp from pter
Size:
71,687 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GLRX1_HUMAN, P35754 (See protein sequence)
Recommended Name: Glutaredoxin-1  
Size: 106 amino acids; 11776 Da
2 PDB 3D structures from and Proteopedia for GLRX:
1B4Q (3D)        1JHB (3D)    
Secondary accessions: B2R4L2 Q3KQS1 Q6ICT1

Explore the universe of human proteins at neXtProt for GLRX: NX_P35754

Explore proteomics data for GLRX at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys9, Lys20
  • Modification sites at PhosphoSitePlus

  • See GLRX Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001112362.1  NP_001230587.1  NP_001230588.1  NP_002055.1  

    ENSEMBL proteins: 
     ENSP00000422708   ENSP00000237858   ENSP00000369314   ENSP00000427353   ENSP00000424636  
    Reactome Protein details: P35754

    GLRX Human Recombinant Protein Products:

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    Sino Biological Recombinant Protein for GLRX
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for GLRX

     
    Search eBioscience for Proteins for GLRX 

    GLRX Antibody Products:

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    Cloud-Clone Corp. ELISAs for GLRX
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    Search eBioscience for ELISAs for GLRX 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR002109 Glutaredoxin
     IPR014025 Glutaredoxin_subgr
     IPR011767 GLR_AS
     IPR012336 Thioredoxin-like_fold
     IPR011899 Glutaredoxin_euk/vir

    Graphical View of Domain Structure for InterPro Entry P35754

    ProtoNet protein and cluster: P35754

    1 Blocks protein domain: IPB002109 Glutaredoxin

    UniProtKB/Swiss-Prot: GLRX1_HUMAN, P35754
    Similarity: Belongs to the glutaredoxin family
    Similarity: Contains 1 glutaredoxin domain


    Find genes that share domains with GLRX           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GLRX1_HUMAN, P35754
    Function: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase.
    Reduces low molecular weight disulfides and proteins

         Genatlas biochemistry entry for GLRX:
    glutaredoxin,12kDa,catalyzing glutathione-dependent disulfide oxidoreduction

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009055electron carrier activity IEA--
    GO:0015035protein disulfide oxidoreductase activity IEA--
    GO:0015038glutathione disulfide oxidoreductase activity TAS7851394
    GO:0047485protein N-terminus binding IPI16884690
         
    Find genes that share ontologies with GLRX           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for GLRX:
     Increased gamma-H2AX phosphory 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Glrx):
     cardiovascular system  cellular  respiratory system  vision/eye 

    Find genes that share phenotypes with GLRX           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for GLRX: Glrxtm3Ysh Glrxtm1Ysh

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GLRX
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GLRX

    miRNA
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    miRTarBase miRNAs that target GLRX:
    hsa-mir-26b-5p (MIRT029425), hsa-mir-128-3p (MIRT021981), hsa-mir-30a-5p (MIRT028491), hsa-mir-103a-3p (MIRT027076), hsa-mir-16-5p (MIRT031719)

    Block miRNA regulation of human, mouse, rat GLRX using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GLRX (see all 16):
    hsa-let-7d hsa-miR-429 hsa-miR-200a hsa-let-7c hsa-miR-141 hsa-let-7g hsa-let-7a hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidGLRX 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for GLRX
    Predesigned siRNA for gene silencing in human, mouse, rat GLRX

    Gene Editing
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): GLRX (NM_002064)
    Sino Biological Human cDNA Clone for GLRX
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GLRX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GLRX

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GLRX


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GLRX1_HUMAN, P35754: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    plasma membrane3
    chloroplast2
    mitochondrion2
    nucleus2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol TAS16884690
    GO:0070062extracellular vesicular exosome IDA19199708

    Find genes that share ontologies with GLRX           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GLRX About    
    See pathways by source

    SuperPathContained pathways About
    1Purine metabolism (REACTOME)
    Metabolism of nucleotides0.42
    Synthesis and interconversion of nucleotide di- and triphosphates0.00
    2PAK Pathway
    Antioxidant Action of Vitamin-C0.56
    3Metabolism
    Metabolism0.38
    4ascorbate recycling (cytosolic)
    ascorbate recycling (cytosolic)


    Find genes that share SuperPaths with GLRX           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for GLRX
        Antioxidant Action of Vitamin-C

    1 BioSystems Pathway for GLRX
        ascorbate recycling (cytosolic)


    1 Reactome Pathway for GLRX
        Synthesis and interconversion of nucleotide di- and triphosphates


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GLRX
    Interactions:

        GeneGlobe Interaction Network for GLRX

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GLRX (P357542, 3 ENSP000002378584) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GOT2P005052, 3, ENSP000002452064MINT-8256514 I2D: score=2 STRING: ENSP00000245206
    MAP3K5Q996833, ENSP000003519084I2D: score=4 STRING: ENSP00000351908
    ATP7AQ046563, ENSP000003457284I2D: score=1 STRING: ENSP00000345728
    NFICP086513, ENSP000003968434I2D: score=1 STRING: ENSP00000396843
    ATP7BP356703, ENSP000002428394I2D: score=1 STRING: ENSP00000242839
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015949nucleobase-containing small molecule interconversion TAS--
    GO:0044281small molecule metabolic process TAS--
    GO:0045454cell redox homeostasis IEA--
    GO:0055086nucleobase-containing small molecule metabolic process TAS--

    Find genes that share ontologies with GLRX           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GLRX (GLRX1)

    1 HMDB Compound for GLRX    About this table
    CompoundSynonyms CAS #PubMed Ids
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--

    1 DrugBank Compound for GLRX    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 5)70-18-8target--17460036 17512091 17640917 17327665 17431186

    Selected Novoseek inferred chemical compound relationships for GLRX gene (see all 46)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dithiol 89.5 16 14713336 (2), 11297543 (1), 14503974 (1), 14522978 (1) (see all 10)
    hydroxyethyl disulfide 86.2 2 7851394 (1), 9626572 (1)
    gssg 82.5 17 12556467 (3), 16893901 (2), 9417094 (1), 11101698 (1) (see all 12)
    dehydroascorbic acid 78.9 27 8645179 (5), 2394726 (2), 13129525 (2), 12950457 (1) (see all 13)
    gsno 69.2 2 19366212 (1), 12556467 (1)
    cysteine 66.7 24 8914835 (3), 11832487 (2), 17546662 (2), 12244106 (1) (see all 16)
    cys7 65.6 3 8549805 (2), 7851394 (1)
    nadph 62.3 33 15983215 (3), 15351709 (1), 16893901 (1), 7851394 (1) (see all 18)
    iron-sulfur 60 7 16800625 (3), 17121859 (1)
    selenol 59.3 1 17115886 (1)



    Find genes that share compounds with GLRX           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GLRX gene (4 alternative transcripts): 
    NM_001118890.1  NM_001243658.1  NM_001243659.1  NM_002064.2  

    Unigene Cluster for GLRX:

    Glutaredoxin (thioltransferase)
    Hs.28988  [show with all ESTs]
    Unigene Representative Sequence: AK094753
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000508780 ENST00000507605 ENST00000237858(uc021ybn.1 uc003klo.4)
    ENST00000379979(uc003kln.4 uc021ybo.1) ENST00000507412 ENST00000505427
    ENST00000512469
    miRNA
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    hsa-let-7d hsa-miR-429 hsa-miR-200a hsa-let-7c hsa-miR-141 hsa-let-7g hsa-let-7a hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidGLRX 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat GLRX
      QuantiFast Probe-based Assays in human, mouse, rat GLRX

    Additional mRNA sequence: 

    AF069668.1 AF162769.1 AK094753.1 AK311868.1 BC005304.1 BC010965.1 BC106075.1 BT006689.1 
    CR450312.1 CR542165.1 D21238.1 X76648.1 

    18 DOTS entries:

    DT.453131  DT.101956627  DT.100812547  DT.100812552  DT.100681996  DT.91749949  DT.100812550  DT.95173522 
    DT.97773012  DT.100042083  DT.120838029  DT.92444994  DT.95173518  DT.120835373  DT.218693  DT.120837846 
    DT.120845059  DT.97764833 

    Selected AceView cDNA sequences (see all 318):

    BG571734 BM740284 BM784616 BM710419 BM708182 BM272971 BQ574751 BU928631 
    BX432330 W74537 BG469024 BM740052 CR450312 CA406083 CR593859 CR611519 
    CR618562 BQ001592 BM848893 CB162853 BX439526 N47980 CR542165 AI127891 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GLRX expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGTTTGCCT
    GLRX Expression
    About this image


    GLRX expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)
             Blimp1- mVenus and stella-ECFP genetically modified stem cells
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Colon (Gastrointestinal Tract)
     
     Kidney (Urinary System)
    GLRX Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GLRX Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.28988
        Custom PCR Arrays for GLRX
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GLRX

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for GLRX gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Glrx1 , 5 glutaredoxin1, 5 87.42(n)1
    89.62(a)1
      13 (40.95 cM)5
    936921  NM_053108.41  NP_444338.21 
     758398685 
    chicken
    (Gallus gallus)
    Aves GLRX1 glutaredoxin (thioltransferase) 58.33(n)
    52(a)
      396069  NM_205160.1  NP_990491.1 
    lizard
    (Anolis carolinensis)
    Reptilia GLRX6
    glutaredoxin (thioltransferase)
    57(a)
    1 ↔ 1
    2(26012860-26017094)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia glrx1 glutaredoxin (thioltransferase) 58.1(n)
    52.38(a)
      549351  NM_001016597.2  NP_001016597.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc38f022 Transcribed sequence with weak similarity to protein more 73.72(n)    BM037310.1 
    worm
    (Caenorhabditis elegans)
    Secernentea glrx-101 glrx-10 53.33(n)
    44.76(a)
      171685  NM_058411.5  NP_490812.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GRX16
    GRX26
    Hydroperoxide and superoxide-radical responsive he...
    Cytoplasmic glutaredoxin, thioltransferase, glutat...
    30(a)
    24(a)
    many ↔ many
    many ↔ many
    III(60841-61173) YCL035C
    IV(1471017-1471448) YDR513W


    ENSEMBL Gene Tree for GLRX (if available)
    TreeFam Gene Tree for GLRX (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GLRX gene
    GLRX22  
    3 SIMAP similar genes for GLRX using alignment to 1 protein entry:     GLRX1_HUMAN:
    TXNRD3    GLRX5    GLRX2

    Find genes that share paralogs with GLRX           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for GLRX
    PGOHUM00000248252 PGOHUM00000247529 PGOHUM00000251343


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GLRX (see all 230)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs606592321,2
    C--95156395(+) AAAAA-/AGCAAT 4 -- int10--------
    rs1845798741,2
    --95432962(+) ACCTCC/TGGTGG 4 -- ds50010--------
    rs170851331,2
    C,F--95433076(+) AGGGCC/ACACAA 4 -- ds50019Minor allele frequency- A:0.01NA NS WA 450
    rs1469658241,2
    --95433237(+) TTGTAC/TTCAGT 4 -- ds50010--------
    rs1378819841,2
    --95433258(+) AGCACA/GTGTCT 4 -- ut310--------
    rs1494696891,2
    C--95433276(+) TAATGC/GCAGGG 4 -- ut310--------
    rs1441325381,2
    C--95433317(+) ATTTCA/GCATAA 4 -- ut310--------
    rs20071,2
    C,F,O,A,H--95433348(+) ACATGC/GAAATG 4 -- ut31 ese333Minor allele frequency- N:0.00EA MN NA NS WA CSA 3281
    rs1877078661,2
    --95433374(+) ACTGAA/TTCATC 4 -- ut310--------
    rs1455103791,2
    C--95433386(+) ATAGG-/TTTT  
            
    TTTTA
    4 -- ut310--------

    HapMap Linkage Disequilibrium report for GLRX (95087023 - 95158709 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for GLRX:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv882389CNV Loss21882294
    nsv462255CNV Loss19166990
    nsv830409CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600443    OMIM disorders: --

    3 diseases for GLRX:    
    About MalaCards
    pancreatic cystadenocarcinoma    transitional meningioma    pancreatic cancer

    1 disease from the University of Copenhagen DISEASES database for GLRX:
    Pancreatic cystadenocarcinoma

    Find genes that share disorders with GLRX           About GenesLikeMe

    Selected Novoseek inferred disease relationships for GLRX gene (see all 15)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neurodegenerative diseases 15.9 1 18560520 (1)
    cell damage 6.54 2 16895798 (1), 16160061 (1)
    cardiovascular diseases 0 1 17172268 (1)
    carcinoma squamous cell 0 1 12532421 (1)
    necrosis 0 8 17185628 (5), 15737590 (1), 17272816 (1), 15826869 (1)
    shock 0 6 15896550 (3), 15109915 (1), 15059518 (1)
    atherosclerosis 0 1 11557676 (1)
    brain tumors 0 2 10807983 (1), 17457608 (1)
    tumors 0 8 17185628 (5), 15737590 (1), 17272816 (1), 15826869 (1)
    pancreatic cancer 0 1 10757123 (1)

    Genetic Association Database (GAD): GLRX
    Human Genome Epidemiology (HuGE) Navigator: GLRX (6 documents)

    Export disorders for GLRX gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GLRX gene, integrated from 10 sources (see all 267):
    (articles sorted by number of sources associating them with GLRX)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Purification from placenta, amino acid sequence, structure comparisons and cDNA cloning of human glutaredoxin. (PubMed id 7851394)1, 2, 9 Padilla C.A....Holmgren A. (Eur. J. Biochem. 1995)
    2. Purification, cloning and expression of dehydroascorbic acid-reducing activity from human neutrophils: identification as glutaredoxin. (PubMed id 8645179)1, 2, 9 Park J.B. and Levine M. (Biochem. J. 1996)
    3. The NMR solution structure of human glutaredoxin in the fully reduced form. (PubMed id 9677297)1, 2, 9 Sun C.... Bushweller J.H. (J. Mol. Biol. 1998)
    4. The gene for human glutaredoxin (GLRX) is localized to human chromosome 5q14. (PubMed id 8838810)1, 3, 9 Padilla C.A....Holmgren A. (Genomics 1996)
    5. Cloning and sequencing of the cDNA encoding human glutaredoxin. (PubMed id 8018729)1, 2, 9 Fernando M.R.... Takeshige K. (Biochim. Biophys. Acta 1994)
    6. The primary structure and properties of thioltransferase (glutaredoxin) from human red blood cells. (PubMed id 8019414)1, 2, 9 Papov V.V.... Biemann K. (Protein Sci. 1994)
    7. Low 8-oxo-7,8-dihydro-2'-deoxyguanosine levels and influence of genetic background in an Andean population exposed to high levels of arsenic. (PubMed id 19896490)1, 4, 9 EngstrAPm K.S....Broberg K. (Mutat. Res. 2010)
    8. Arsenic metabolism is influenced by polymorphisms in genes involved in one-carbon metabolism and reduction reactions. (PubMed id 18682255)1, 4, 9 SchlAowicke EngstrAPm K....Broberg K. (Mutat. Res. 2009)
    9. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    10. The ERAP2 gene is associated with preeclampsia in Australian and Norwegian populations. (PubMed id 19578876)1, 4 Johnson M.P....Moses E.K. (Hum. Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2745 HGNC: 4330 AceView: GLRX Ensembl:ENSG00000173221 euGenes: HUgn2745
    ECgene: GLRX H-InvDB: GLRX

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GLRX Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/glrx/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GLRX gene:
    Search GeneIP for patents involving GLRX

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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