Aliases for GLRX Gene
External Ids for GLRX Gene
Previous GeneCards Identifiers for GLRX Gene
This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer's disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2011]
GeneCards Summary for GLRX Gene
GLRX (Glutaredoxin) is a Protein Coding gene. Diseases associated with GLRX include Alzheimer Disease and Pancreatic Cystadenocarcinoma. Among its related pathways are Metabolism and Purine metabolism (REACTOME). GO annotations related to this gene include protein N-terminus binding and protein disulfide oxidoreductase activity. An important paralog of this gene is GLRX2.
UniProtKB/Swiss-Prot for GLRX Gene
Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.