Aliases for GLRX Gene
External Ids for GLRX Gene
Previous GeneCards Identifiers for GLRX Gene
This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer's disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2011]
GeneCards Summary for GLRX Gene
GLRX (Glutaredoxin) is a Protein Coding gene. Diseases associated with GLRX include alzheimer disease and pancreatic cystadenocarcinoma. Among its related pathways are Metabolism and PAK Pathway. GO annotations related to this gene include protein N-terminus binding and protein disulfide oxidoreductase activity. An important paralog of this gene is GLRX2.
UniProtKB/Swiss-Prot for GLRX Gene
Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.