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Aliases for GLRA3 Gene

Aliases for GLRA3 Gene

  • Glycine Receptor, Alpha 3 2 3

External Ids for GLRA3 Gene

Previous GeneCards Identifiers for GLRA3 Gene

  • GC04M176484
  • GC04M176102
  • GC04M176259
  • GC04M175938
  • GC04M175800
  • GC04M175558
  • GC04M171312

Summaries for GLRA3 Gene

Entrez Gene Summary for GLRA3 Gene

  • This gene encodes a member of the ligand-gated ion channel protein family. The encoded protein is a member of the glycine receptor subfamily. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

GeneCards Summary for GLRA3 Gene

GLRA3 (Glycine Receptor, Alpha 3) is a Protein Coding gene. Diseases associated with GLRA3 include hyperekplexia. Among its related pathways are Ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include extracellular ligand-gated ion channel activity and extracellular-glycine-gated chloride channel activity. An important paralog of this gene is GABRR1.

UniProtKB/Swiss-Prot for GLRA3 Gene

  • The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing)

Tocris Summary for GLRA3 Gene

  • Glycine receptors (GlyR) are members of the cys-loop family of ligand-gated ion channels, responsible for mediating the inhibitory effects of glycine. They are widely distributed throughout the CNS, particularly within the hippocampus, spinal cord and brain stem. Glycine receptors exist as pentameric proteins, homo-oligomers of the alpha isoforms (alpha1, alpha2, alpha3 or alpha4) or hetero-oligomers which also contain the beta-subtype variant (beta1) which is essential for targeting the receptor to the synapse. Glycine receptors contain an integral chloride channel, and have modulatory sites for anesthetics, neurosteroids, cannabinoids and ethanol. Disruption in glycine receptor expression or ion channel function can result in hyperekplexia, a rare neurological disorder.

Gene Wiki entry for GLRA3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLRA3 Gene

Genomics for GLRA3 Gene

Genomic Location for GLRA3 Gene

174,636,914 bp from pter
174,829,315 bp from pter
192,402 bases
Minus strand

Genomic View for GLRA3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GLRA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLRA3 Gene

Proteins for GLRA3 Gene

  • Protein details for GLRA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Glycine receptor subunit alpha-3
    Protein Accession:
    Secondary Accessions:
    • D3DP44
    • O75816
    • Q5D0E3

    Protein attributes for GLRA3 Gene

    464 amino acids
    Molecular mass:
    53800 Da
    Quaternary structure:
    • Pentamer composed of alpha and beta subunits.
    • The alpha subunit binds strychnine

    Alternative splice isoforms for GLRA3 Gene


neXtProt entry for GLRA3 Gene

Proteomics data for GLRA3 Gene at MOPED

Post-translational modifications for GLRA3 Gene

  • Glycosylation at Asn71
  • Modification sites at PhosphoSitePlus

Other Protein References for GLRA3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for GLRA3 Gene

Domains for GLRA3 Gene

Gene Families for GLRA3 Gene

  • GLRA :Ligand-gated ion channels / Glycine receptors

Suggested Antigen Peptide Sequences for GLRA3 Gene

Graphical View of Domain Structure for InterPro Entry



  • O75311
  • The N-terminal domain carries structural determinants essential for agonist and antagonist binding. TM2 is thought to form the innert wall of the chloride channel. The cytoplasmic loop is an important determinant of channel inactivation kinetics
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA3 sub-subfamily.
genes like me logo Genes that share domains with GLRA3: view

Function for GLRA3 Gene

Molecular function for GLRA3 Gene

GENATLAS Biochemistry:
glycine receptor,alpha 3 subunit expressed in the central nervous system,with two splice variants GLRA3L,GLRA3K
UniProtKB/Swiss-Prot Function:
The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing)

Gene Ontology (GO) - Molecular Function for GLRA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005230 extracellular ligand-gated ion channel activity --
GO:0016594 glycine binding IEA --
GO:0016934 extracellular-glycine-gated chloride channel activity IEA --
GO:0022824 transmitter-gated ion channel activity IEA --
genes like me logo Genes that share ontologies with GLRA3: view
genes like me logo Genes that share phenotypes with GLRA3: view

Animal Models for GLRA3 Gene

MGI Knock Outs for GLRA3:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for GLRA3 Gene

Localization for GLRA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLRA3 Gene

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for GLRA3 Gene COMPARTMENTS Subcellular localization image for GLRA3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GLRA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with GLRA3: view

Pathways for GLRA3 Gene

genes like me logo Genes that share pathways with GLRA3: view

Pathways by source for GLRA3 Gene

Interacting Proteins for GLRA3 Gene

Gene Ontology (GO) - Biological Process for GLRA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0006811 ion transport --
GO:0034220 ion transmembrane transport TAS --
GO:0055085 transmembrane transport TAS --
GO:1902476 chloride transmembrane transport IEA --
genes like me logo Genes that share ontologies with GLRA3: view

Compounds for GLRA3 Gene

(5) Tocris Compounds for GLRA3 Gene

Compound Action Cas Number
beta-Alanine Endogenous glycine agonist, more selective than taurine (Cat. No. 0209) [107-95-9]
Hypotaurine Non-selective endogenous glycine receptor agonist [300-84-5]
L-Alanine Glycine receptor agonist [56-41-7]
L-Serine Weak endogenous glycine receptor agonist [56-45-1]
Taurine Non-selective, endogenous glycine receptor partial agonist [107-35-7]

(2) HMDB Compounds for GLRA3 Gene

Compound Synonyms Cas Number PubMed IDs
  • Cl2
  • 2-Aminoacetate

(4) Drugbank Compounds for GLRA3 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
  • 2-Aminoacetic acid
56-40-6 target
  • 22,23-Dihydroxy-avermectin B
70288-86-7 target agonist
  • Benzene hexachloride
58-89-9 target antagonist
124-87-8 target antagonist

(14) IUPHAR Ligand for GLRA3 Gene

Ligand Type Action Affinity Pubmed IDs
HU-210 Antagonist Antagonist 7
WIN55212-2 Antagonist Antagonist 6.7
picrotoxinin Channel blocker None 6.4
HU-308 Antagonist Antagonist 6
Zn2+ Channel blocker None 6
ginkgolide B Channel blocker None 5.4
(12E,20Z,18S)-8-hydroxyvariabilin Antagonist Antagonist 5.2
picrotin Channel blocker None 4.9
Cu2+ Allosteric regulator Inhibition 4.8
Delta9-tetrahydrocannabinol Channel blocker None
nifedipine Activator None
strychnine Antagonist Antagonist
[3H]strychnine None None
picrotoxin Channel blocker None
genes like me logo Genes that share compounds with GLRA3: view

Transcripts for GLRA3 Gene

Unigene Clusters for GLRA3 Gene

Glycine receptor, alpha 3:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GLRA3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GLRA3 Gene

No ASD Table

Relevant External Links for GLRA3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GLRA3 Gene

mRNA expression in normal human tissues for GLRA3 Gene

mRNA differential expression in normal tissues according to GTEx for GLRA3 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (8.4), Brain - Anterior cingulate cortex (BA24) (8.3), Brain - Hypothalamus (7.3), Brain - Cortex (6.1), and Brain - Substantia nigra (4.2).

Protein differential expression in normal tissues for GLRA3 Gene

This gene is overexpressed in Retina (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for GLRA3 Gene

SOURCE GeneReport for Unigene cluster for GLRA3 Gene Hs.413099

mRNA Expression by UniProt/SwissProt for GLRA3 Gene

Tissue specificity: Widely distributed throughout the central nervous system
genes like me logo Genes that share expressions with GLRA3: view

Expression partners for GLRA3 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for GLRA3 Gene

Orthologs for GLRA3 Gene

This gene was present in the common ancestor of animals.

Orthologs for GLRA3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GLRA3 35
  • 91.85 (n)
  • 97.84 (a)
GLRA3 36
  • 98 (a)
(Canis familiaris)
Mammalia GLRA3 35
  • 93.47 (n)
  • 99.78 (a)
GLRA3 36
  • 100 (a)
(Mus musculus)
Mammalia Glra3 35
  • 89.44 (n)
  • 98.92 (a)
Glra3 16
Glra3 36
  • 96 (a)
(Pan troglodytes)
Mammalia GLRA3 35
  • 99.57 (n)
  • 100 (a)
GLRA3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Glra3 35
  • 88.79 (n)
  • 98.28 (a)
(Monodelphis domestica)
Mammalia GLRA3 36
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia GLRA3 36
  • 95 (a)
(Gallus gallus)
Aves GLRA3 35
  • 80.49 (n)
  • 90.71 (a)
GLRA3 36
  • 94 (a)
(Anolis carolinensis)
Reptilia GLRA3 36
  • 90 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia glra3 35
  • 80.58 (n)
  • 93.53 (a)
(Danio rerio)
Actinopterygii glra3 35
  • 74.19 (n)
  • 88.14 (a)
GLRA3 36
  • 75 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11340 37
  • 32 (a)
CG6927 37
  • 31 (a)
CG7589 37
  • 25 (a)
GluClalpha 37
  • 40 (a)
Grd 37
  • 47 (a)
ort 37
  • 43 (a)
Rdl 37
  • 46 (a)
(Caenorhabditis elegans)
Secernentea avr-14 37
  • 38 (a)
C39B10.2 37
  • 37 (a)
C53D6.3 37
  • 33 (a)
F09G2.5 37
  • 29 (a)
F11H8.2 37
  • 36 (a)
F55D10.5 37
  • 35 (a)
F58G6.4 37
  • 29 (a)
gbr-4 37
  • 36 (a)
gbr-5 37
  • 36 (a)
gbr-6 37
  • 33 (a)
glc-1 37
  • 37 (a)
glc-2 37
  • 37 (a)
glc-3 37
  • 36 (a)
glc-4 37
  • 31 (a)
K10D6.1 37
  • 31 (a)
T20B12.9 37
  • 30 (a)
T24D8.1 37
  • 35 (a)
T27E9.9 37
  • 33 (a)
W10G11.16 37
  • 30 (a)
Y39A3B.2 37
  • 36 (a)
Y71D11A.5 37
  • 29 (a)
Y73F8A.2 37
  • 28 (a)
glc-2 35
  • 50.58 (n)
  • 43.73 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 60 (a)
Species with no ortholog for GLRA3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GLRA3 Gene

Gene Tree for GLRA3 (if available)
Gene Tree for GLRA3 (if available)

Paralogs for GLRA3 Gene

genes like me logo Genes that share paralogs with GLRA3: view

Variants for GLRA3 Gene

Sequence variations from dbSNP and Humsavar for GLRA3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs25400 -- 174,682,438(+) AATTT(A/T)AAAAA intron-variant
rs952561 -- 174,826,376(+) TTATA(G/T)AAGTC intron-variant
rs959368 -- 174,762,650(+) TCACC(A/G)AATAG intron-variant
rs968874 -- 174,764,474(+) TCCTC(C/T)CAATT intron-variant
rs979360 -- 174,760,974(+) ATGTG(G/T)ATACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GLRA3 Gene

Variant ID Type Subtype PubMed ID
nsv880584 CNV Loss 21882294
esv988593 CNV Deletion 20482838
esv2672036 CNV Deletion 23128226
dgv911n67 CNV Loss 20364138
nsv821054 CNV Deletion 20802225
esv2728767 CNV Deletion 23290073
esv9678 CNV Loss 19470904
dgv993e199 CNV Deletion 23128226
esv22642 CNV Gain 19812545
esv1917201 CNV Deletion 18987734
nsv830156 CNV Gain 17160897
nsv507220 CNV Insertion 20534489

Relevant External Links for GLRA3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLRA3 Gene

Disorders for GLRA3 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for GLRA3 Gene in MalaCards »

(1) Diseases for GLRA3 Gene including...

Relevant External Links for GLRA3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with GLRA3: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for GLRA3 Gene

Publications for GLRA3 Gene

  1. The human glycine receptor subunit alpha3. GLRA3 gene structure, chromosomal localization, and functional characterization of alternative transcripts. (PMID: 9677400) Nikolic Z. … Becker C.-M. (J. Biol. Chem. 1998) 2 3 4 23
  2. Genetic variation of the human glycine receptor subunit genes GLRA3 and GLRB and susceptibility to idiopathic generalized epilepsies. (PMID: 11496371) Sobetzko D. … Becker C.M. (Am. J. Med. Genet. 2001) 3 48
  3. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PMID: 19086053) GratacA^s M. … Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 48
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Hydroxylated residues influence desensitization behaviour of recombinant alpha3 glycine receptor channels. (PMID: 12358726) Breitinger H.G. … Becker C.M. (J. Neurochem. 2002) 3 23

Products for GLRA3 Gene

Sources for GLRA3 Gene

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