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Aliases for GLRA3 Gene

Aliases for GLRA3 Gene

  • Glycine Receptor, Alpha 3 2 3

External Ids for GLRA3 Gene

Previous GeneCards Identifiers for GLRA3 Gene

  • GC04M176484
  • GC04M176102
  • GC04M176259
  • GC04M175938
  • GC04M175800
  • GC04M175558
  • GC04M171312

Summaries for GLRA3 Gene

Entrez Gene Summary for GLRA3 Gene

  • This gene encodes a member of the ligand-gated ion channel protein family. The encoded protein is a member of the glycine receptor subfamily. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

GeneCards Summary for GLRA3 Gene

GLRA3 (Glycine Receptor, Alpha 3) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Ion channel transport. GO annotations related to this gene include extracellular ligand-gated ion channel activity and extracellular-glycine-gated chloride channel activity. An important paralog of this gene is GABRR1.

UniProtKB/Swiss-Prot for GLRA3 Gene

  • The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing)

Tocris Summary for GLRA3 Gene

  • Glycine receptors (GlyR) are members of the cys-loop family of ligand-gated ion channels, responsible for mediating the inhibitory effects of glycine. They are widely distributed throughout the CNS, particularly within the hippocampus, spinal cord and brain stem.

Gene Wiki entry for GLRA3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLRA3 Gene

Genomics for GLRA3 Gene

Genomic Location for GLRA3 Gene

Chromosome:
4
Start:
174,624,141 bp from pter
End:
174,829,315 bp from pter
Size:
205,175 bases
Orientation:
Minus strand

Genomic View for GLRA3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GLRA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLRA3 Gene

Proteins for GLRA3 Gene

  • Protein details for GLRA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75311-GLRA3_HUMAN
    Recommended name:
    Glycine receptor subunit alpha-3
    Protein Accession:
    O75311
    Secondary Accessions:
    • D3DP44
    • O75816
    • Q5D0E3

    Protein attributes for GLRA3 Gene

    Size:
    464 amino acids
    Molecular mass:
    53800 Da
    Quaternary structure:
    • Pentamer composed of alpha and beta subunits.
    Miscellaneous:
    • The alpha subunit binds strychnine

    Alternative splice isoforms for GLRA3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GLRA3 Gene

Proteomics data for GLRA3 Gene at MOPED

Post-translational modifications for GLRA3 Gene

  • Glycosylation at Asn 71
  • Modification sites at PhosphoSitePlus

Other Protein References for GLRA3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GLRA3 Gene

Domains & Families for GLRA3 Gene

Gene Families for GLRA3 Gene

Suggested Antigen Peptide Sequences for GLRA3 Gene

Graphical View of Domain Structure for InterPro Entry

O75311

UniProtKB/Swiss-Prot:

GLRA3_HUMAN :
  • The N-terminal domain carries structural determinants essential for agonist and antagonist binding. TM2 is thought to form the innert wall of the chloride channel. The cytoplasmic loop is an important determinant of channel inactivation kinetics
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA3 sub-subfamily.
Domain:
  • The N-terminal domain carries structural determinants essential for agonist and antagonist binding. TM2 is thought to form the innert wall of the chloride channel. The cytoplasmic loop is an important determinant of channel inactivation kinetics
Family:
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA3 sub-subfamily.
genes like me logo Genes that share domains with GLRA3: view

Function for GLRA3 Gene

Molecular function for GLRA3 Gene

GENATLAS Biochemistry:
glycine receptor,alpha 3 subunit expressed in the central nervous system,with two splice variants GLRA3L,GLRA3K
UniProtKB/Swiss-Prot Function:
The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing)

Gene Ontology (GO) - Molecular Function for GLRA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005230 extracellular ligand-gated ion channel activity --
GO:0016594 contributes_to glycine binding IBA --
GO:0016934 contributes_to extracellular-glycine-gated chloride channel activity IBA --
GO:0022824 transmitter-gated ion channel activity IEA --
genes like me logo Genes that share ontologies with GLRA3: view
genes like me logo Genes that share phenotypes with GLRA3: view

Animal Models for GLRA3 Gene

MGI Knock Outs for GLRA3:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for GLRA3 Gene

Localization for GLRA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLRA3 Gene

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GLRA3 Gene COMPARTMENTS Subcellular localization image for GLRA3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GLRA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0009897 external side of plasma membrane IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with GLRA3: view

Pathways & Interactions for GLRA3 Gene

genes like me logo Genes that share pathways with GLRA3: view

Pathways by source for GLRA3 Gene

Interacting Proteins for GLRA3 Gene

Gene Ontology (GO) - Biological Process for GLRA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0006811 ion transport --
GO:0007218 neuropeptide signaling pathway IBA --
GO:0034220 ion transmembrane transport TAS --
GO:0042391 regulation of membrane potential IBA --
genes like me logo Genes that share ontologies with GLRA3: view

No data available for SIGNOR curated interactions for GLRA3 Gene

Drugs & Compounds for GLRA3 Gene

(21) Drugs for GLRA3 Gene - From: IUPHAR, DGIdb, Tocris, HMDB, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nifedipine Approved Pharma Activator, blocker 104
Ivermectin Approved Pharma Target, agonist NAChR/purinergic P2X4 receptor modulator, Allosteric modulator of alpha7 nicotinic receptors 45
Lindane Approved, Withdrawn Pharma Target, antagonist 0
Glycine Approved Nutra Agonist, Target Endogenous potentiator, co-transmitter 102
L-Alanine Approved Nutra Full agonist, Agonist Glycine receptor agonist 0

(3) Additional Compounds for GLRA3 Gene - From: IUPHAR, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Delta<sup>9</sup>-tetrahydrocannabinol
Channel blocker
Chloride ion
  • Bertholite
  • Chloor
  • Chlor
  • Chlore
  • Chloride
16887-00-6
Hypotaurine
  • 2-Amino-Ethanesulfinate
  • 2-Amino-Ethanesulfinic acid
  • 2-Aminoethanesulfinate
  • 2-Aminoethanesulfinic acid
  • 2-Aminoethylsulfinate
300-84-5
genes like me logo Genes that share compounds with GLRA3: view

Transcripts for GLRA3 Gene

Unigene Clusters for GLRA3 Gene

Glycine receptor, alpha 3:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GLRA3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GLRA3 Gene

No ASD Table

Relevant External Links for GLRA3 Gene

GeneLoc Exon Structure for
GLRA3
ECgene alternative splicing isoforms for
GLRA3

Expression for GLRA3 Gene

mRNA expression in normal human tissues for GLRA3 Gene

mRNA differential expression in normal tissues according to GTEx for GLRA3 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x8.4), Brain - Anterior cingulate cortex (BA24) (x8.3), Brain - Hypothalamus (x7.3), Brain - Cortex (x6.1), and Brain - Substantia nigra (x4.2).

Protein differential expression in normal tissues from HIPED for GLRA3 Gene

This gene is overexpressed in Retina (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GLRA3 Gene



SOURCE GeneReport for Unigene cluster for GLRA3 Gene Hs.413099

mRNA Expression by UniProt/SwissProt for GLRA3 Gene

O75311-GLRA3_HUMAN
Tissue specificity: Widely distributed throughout the central nervous system
genes like me logo Genes that share expression patterns with GLRA3: view

Protein tissue co-expression partners for GLRA3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for GLRA3 Gene

Orthologs for GLRA3 Gene

This gene was present in the common ancestor of animals.

Orthologs for GLRA3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GLRA3 35
  • 91.85 (n)
  • 97.84 (a)
GLRA3 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GLRA3 35
  • 93.47 (n)
  • 99.78 (a)
GLRA3 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Glra3 35
  • 89.44 (n)
  • 98.92 (a)
Glra3 16
Glra3 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GLRA3 35
  • 99.57 (n)
  • 100 (a)
GLRA3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Glra3 35
  • 88.79 (n)
  • 98.28 (a)
oppossum
(Monodelphis domestica)
Mammalia GLRA3 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GLRA3 36
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves GLRA3 35
  • 80.49 (n)
  • 90.71 (a)
GLRA3 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GLRA3 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia glra3 35
  • 80.58 (n)
  • 93.53 (a)
zebrafish
(Danio rerio)
Actinopterygii glra3 35
  • 74.19 (n)
  • 88.14 (a)
GLRA3 36
  • 75 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11340 37
  • 32 (a)
CG6927 37
  • 31 (a)
CG7589 37
  • 25 (a)
GluClalpha 37
  • 40 (a)
Grd 37
  • 47 (a)
ort 37
  • 43 (a)
Rdl 37
  • 46 (a)
worm
(Caenorhabditis elegans)
Secernentea avr-14 37
  • 38 (a)
C39B10.2 37
  • 37 (a)
C53D6.3 37
  • 33 (a)
F09G2.5 37
  • 29 (a)
F11H8.2 37
  • 36 (a)
F55D10.5 37
  • 35 (a)
F58G6.4 37
  • 29 (a)
gbr-4 37
  • 36 (a)
gbr-5 37
  • 36 (a)
gbr-6 37
  • 33 (a)
glc-1 37
  • 37 (a)
glc-2 37
  • 37 (a)
glc-3 37
  • 36 (a)
glc-4 37
  • 31 (a)
K10D6.1 37
  • 31 (a)
T20B12.9 37
  • 30 (a)
T24D8.1 37
  • 35 (a)
T27E9.9 37
  • 33 (a)
W10G11.16 37
  • 30 (a)
Y39A3B.2 37
  • 36 (a)
Y71D11A.5 37
  • 29 (a)
Y73F8A.2 37
  • 28 (a)
glc-2 35
  • 50.58 (n)
  • 43.73 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 60 (a)
OneToMany
Species with no ortholog for GLRA3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GLRA3 Gene

ENSEMBL:
Gene Tree for GLRA3 (if available)
TreeFam:
Gene Tree for GLRA3 (if available)

Paralogs for GLRA3 Gene

genes like me logo Genes that share paralogs with GLRA3: view

Variants for GLRA3 Gene

Structural Variations from Database of Genomic Variants (DGV) for GLRA3 Gene

Variant ID Type Subtype PubMed ID
nsv880584 CNV Loss 21882294
esv988593 CNV Deletion 20482838
esv2672036 CNV Deletion 23128226
dgv911n67 CNV Loss 20364138
nsv821054 CNV Deletion 20802225
esv2728767 CNV Deletion 23290073
esv9678 CNV Loss 19470904
dgv993e199 CNV Deletion 23128226
esv22642 CNV Gain 19812545
esv1917201 CNV Deletion 18987734
nsv830156 CNV Gain 17160897
nsv507220 CNV Insertion 20534489

Variation tolerance for GLRA3 Gene

Residual Variation Intolerance Score: 28.26% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.13; 22.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GLRA3 Gene

HapMap Linkage Disequilibrium report
GLRA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for GLRA3 Gene

Disorders for GLRA3 Gene

Relevant External Links for GLRA3

Genetic Association Database (GAD)
GLRA3
Human Genome Epidemiology (HuGE) Navigator
GLRA3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GLRA3
genes like me logo Genes that share disorders with GLRA3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GLRA3 Gene

Publications for GLRA3 Gene

  1. The human glycine receptor subunit alpha3. GLRA3 gene structure, chromosomal localization, and functional characterization of alternative transcripts. (PMID: 9677400) Nikolic Z. … Becker C.-M. (J. Biol. Chem. 1998) 2 23 67
  2. Dual actions of lindane (I^-hexachlorocyclohexane) on calcium homeostasis and exocytosis in rat PC12 cells. (PMID: 20600211) Heusinkveld H.J. … Westerink R.H. (Toxicol. Appl. Pharmacol. 2010) 25 26
  3. Molecular determinants of beta-carboline inhibition of the glycine receptor. (PMID: 19619142) Chen X. … Lynch J.W. (J. Neurochem. 2009) 23 67
  4. Novel regulatory site within the TM3-4 loop of human recombinant alpha3 glycine receptors determines channel gating and domain structure. (PMID: 19661067) Breitinger H.G. … Becker C.M. (J. Biol. Chem. 2009) 23 67
  5. A Selective Role for alpha3 Subunit Glycine Receptors in Inflammatory Pain. (PMID: 19915732) Harvey V.L. … Dickenson A.H. (Front Mol Neurosci 2009) 23 67

Products for GLRA3 Gene

Sources for GLRA3 Gene

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