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Aliases for GLRA3 Gene

Aliases for GLRA3 Gene

  • Glycine Receptor Alpha 3 2 3 5

External Ids for GLRA3 Gene

Previous GeneCards Identifiers for GLRA3 Gene

  • GC04M176484
  • GC04M176102
  • GC04M176259
  • GC04M175938
  • GC04M175800
  • GC04M175558
  • GC04M171312

Summaries for GLRA3 Gene

Entrez Gene Summary for GLRA3 Gene

  • This gene encodes a member of the ligand-gated ion channel protein family. The encoded protein is a member of the glycine receptor subfamily. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

GeneCards Summary for GLRA3 Gene

GLRA3 (Glycine Receptor Alpha 3) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and DAG and IP3 signaling. GO annotations related to this gene include extracellular ligand-gated ion channel activity and extracellular-glycine-gated chloride channel activity. An important paralog of this gene is GABRR1.

UniProtKB/Swiss-Prot for GLRA3 Gene

  • Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:9677400, PubMed:26416729). Channel characteristics depend on the subunit composition; heteropentameric channels display faster channel closure (By similarity). Plays an important role in the down-regulation of neuronal excitability (By similarity). Contributes to the generation of inhibitory postsynaptic currents (By similarity). Contributes to increased pain perception in response to increased prostaglandin E2 levels (By similarity). Plays a role in cellular responses to ethanol (By similarity).

Tocris Summary for GLRA3 Gene

  • Glycine receptors (GlyR) are members of the cys-loop family of ligand-gated ion channels, responsible for mediating the inhibitory effects of glycine. They are widely distributed throughout the CNS, particularly within the hippocampus, spinal cord and brain stem.

Gene Wiki entry for GLRA3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLRA3 Gene

Genomics for GLRA3 Gene

Regulatory Elements for GLRA3 Gene

Promoters for GLRA3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GLRA3 on UCSC Golden Path with GeneCards custom track

Genomic Location for GLRA3 Gene

Chromosome:
4
Start:
174,624,141 bp from pter
End:
174,829,315 bp from pter
Size:
205,175 bases
Orientation:
Minus strand

Genomic View for GLRA3 Gene

Genes around GLRA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GLRA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GLRA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLRA3 Gene

Proteins for GLRA3 Gene

  • Protein details for GLRA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75311-GLRA3_HUMAN
    Recommended name:
    Glycine receptor subunit alpha-3
    Protein Accession:
    O75311
    Secondary Accessions:
    • D3DP44
    • O75816
    • Q5D0E3

    Protein attributes for GLRA3 Gene

    Size:
    464 amino acids
    Molecular mass:
    53800 Da
    Quaternary structure:
    • Homopentamer (in vitro) (PubMed:26416729). Heteropentamer composed of GLRA3 and GLRB. Both homopentamers and heteropentamers form functional ion channels, but their characteristics are subtly different (By similarity).
    Miscellaneous:
    • The alpha subunit binds strychnine.

    Three dimensional structures from OCA and Proteopedia for GLRA3 Gene

    Alternative splice isoforms for GLRA3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GLRA3 Gene

Proteomics data for GLRA3 Gene at MOPED

Post-translational modifications for GLRA3 Gene

  • Phosphorylated by PKA; this causes down-regulation of channel activity.
  • Glycosylation at Asn 71
  • Modification sites at PhosphoSitePlus

Other Protein References for GLRA3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GLRA3 Gene

Domains & Families for GLRA3 Gene

Gene Families for GLRA3 Gene

Suggested Antigen Peptide Sequences for GLRA3 Gene

Graphical View of Domain Structure for InterPro Entry

O75311

UniProtKB/Swiss-Prot:

GLRA3_HUMAN :
  • The N-terminal domain carries structural determinants essential for agonist and antagonist binding. The channel pore is formed by pentameric assembly of the second transmembrane domain from all five subunits (PubMed:26416729). The cytoplasmic loop is an important determinant of channel inactivation kinetics.
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA3 sub-subfamily.
Domain:
  • The N-terminal domain carries structural determinants essential for agonist and antagonist binding. The channel pore is formed by pentameric assembly of the second transmembrane domain from all five subunits (PubMed:26416729). The cytoplasmic loop is an important determinant of channel inactivation kinetics.
Family:
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA3 sub-subfamily.
genes like me logo Genes that share domains with GLRA3: view

Function for GLRA3 Gene

Molecular function for GLRA3 Gene

GENATLAS Biochemistry:
glycine receptor,alpha 3 subunit expressed in the central nervous system,with two splice variants GLRA3L,GLRA3K
UniProtKB/Swiss-Prot Function:
Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:9677400, PubMed:26416729). Channel characteristics depend on the subunit composition; heteropentameric channels display faster channel closure (By similarity). Plays an important role in the down-regulation of neuronal excitability (By similarity). Contributes to the generation of inhibitory postsynaptic currents (By similarity). Contributes to increased pain perception in response to increased prostaglandin E2 levels (By similarity). Plays a role in cellular responses to ethanol (By similarity).

Gene Ontology (GO) - Molecular Function for GLRA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016594 contributes_to glycine binding IBA --
genes like me logo Genes that share ontologies with GLRA3: view
genes like me logo Genes that share phenotypes with GLRA3: view

Animal Models for GLRA3 Gene

MGI Knock Outs for GLRA3:

Animal Model Products

  • Taconic Biosciences Mouse Models for GLRA3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GLRA3 Gene

Localization for GLRA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLRA3 Gene

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Perikaryon. Cell projection, dendrite. Cell junction, synapse. Cell membrane; Multi-pass membrane protein. Note=Partially colocalizes with GPHN that is known to mediate receptor clustering at postsynaptic membranes. {ECO:0000250 UniProtKB:P24524}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GLRA3 Gene COMPARTMENTS Subcellular localization image for GLRA3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GLRA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0030425 dendrite IEA --
genes like me logo Genes that share ontologies with GLRA3: view

Pathways & Interactions for GLRA3 Gene

genes like me logo Genes that share pathways with GLRA3: view

Pathways by source for GLRA3 Gene

Interacting Proteins for GLRA3 Gene

Gene Ontology (GO) - Biological Process for GLRA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007218 neuropeptide signaling pathway IBA --
GO:0051260 protein homooligomerization IDA 26416729
GO:0055085 transmembrane transport TAS --
GO:0060012 synaptic transmission, glycinergic IBA --
genes like me logo Genes that share ontologies with GLRA3: view

No data available for SIGNOR curated interactions for GLRA3 Gene

Drugs & Compounds for GLRA3 Gene

(20) Drugs for GLRA3 Gene - From: Tocris, IUPHAR, DGIdb, DrugBank, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glycine Approved Nutra Full agonist, Agonist, Target Endogenous potentiator, co-transmitter 94
Ivermectin Approved Pharma Target, agonist NAChR/purinergic P2X4 receptor modulator 47
Lindane Approved, Withdrawn Pharma Target, antagonist 0
Nifedipine Approved Pharma Antagonist, Gating inhibitor, blocker 106
L-Alanine Approved Nutra Full agonist, Agonist Glycine receptor agonist 0

(3) Additional Compounds for GLRA3 Gene - From: IUPHAR, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Delta<sup>9</sup>-tetrahydrocannabinol
Partial agonist, Agonist
Chloride ion
  • Bertholite
  • Chloor
  • Chlor
  • Chlore
  • Chloride
16887-00-6
Hypotaurine
  • 2-Amino-Ethanesulfinate
  • 2-Amino-Ethanesulfinic acid
  • 2-Aminoethanesulfinate
  • 2-Aminoethanesulfinic acid
  • 2-Aminoethylsulfinate
300-84-5
genes like me logo Genes that share compounds with GLRA3: view

Transcripts for GLRA3 Gene

Unigene Clusters for GLRA3 Gene

Glycine receptor, alpha 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GLRA3 Gene

No ASD Table

Relevant External Links for GLRA3 Gene

GeneLoc Exon Structure for
GLRA3
ECgene alternative splicing isoforms for
GLRA3

Expression for GLRA3 Gene

mRNA expression in normal human tissues for GLRA3 Gene

mRNA differential expression in normal tissues according to GTEx for GLRA3 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x8.4), Brain - Anterior cingulate cortex (BA24) (x8.3), Brain - Hypothalamus (x7.3), Brain - Cortex (x6.1), and Brain - Substantia nigra (x4.2).

Protein differential expression in normal tissues from HIPED for GLRA3 Gene

This gene is overexpressed in Retina (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GLRA3 Gene



SOURCE GeneReport for Unigene cluster for GLRA3 Gene Hs.413099

mRNA Expression by UniProt/SwissProt for GLRA3 Gene

O75311-GLRA3_HUMAN
Tissue specificity: Widely distributed throughout the central nervous system.
genes like me logo Genes that share expression patterns with GLRA3: view

Protein tissue co-expression partners for GLRA3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for GLRA3 Gene

Orthologs for GLRA3 Gene

This gene was present in the common ancestor of animals.

Orthologs for GLRA3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GLRA3 36
  • 100 (a)
OneToOne
GLRA3 35
  • 99.57 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia GLRA3 36
  • 98 (a)
OneToOne
GLRA3 35
  • 91.85 (n)
  • 97.84 (a)
dog
(Canis familiaris)
Mammalia GLRA3 35
  • 93.47 (n)
  • 99.78 (a)
GLRA3 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Glra3 16
Glra3 36
  • 96 (a)
OneToOne
Glra3 35
  • 89.44 (n)
  • 98.92 (a)
oppossum
(Monodelphis domestica)
Mammalia GLRA3 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GLRA3 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Glra3 35
  • 88.79 (n)
  • 98.28 (a)
chicken
(Gallus gallus)
Aves GLRA3 35
  • 80.49 (n)
  • 90.71 (a)
GLRA3 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GLRA3 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia glra3 35
  • 80.58 (n)
  • 93.53 (a)
zebrafish
(Danio rerio)
Actinopterygii glra3 35
  • 74.19 (n)
  • 88.14 (a)
GLRA3 36
  • 75 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11340 37
  • 32 (a)
CG6927 37
  • 31 (a)
CG7589 37
  • 25 (a)
GluClalpha 37
  • 40 (a)
Grd 37
  • 47 (a)
ort 37
  • 43 (a)
Rdl 37
  • 46 (a)
worm
(Caenorhabditis elegans)
Secernentea glc-2 35
  • 50.58 (n)
  • 43.73 (a)
avr-14 37
  • 38 (a)
C39B10.2 37
  • 37 (a)
C53D6.3 37
  • 33 (a)
F09G2.5 37
  • 29 (a)
F11H8.2 37
  • 36 (a)
F55D10.5 37
  • 35 (a)
F58G6.4 37
  • 29 (a)
gbr-4 37
  • 36 (a)
gbr-5 37
  • 36 (a)
gbr-6 37
  • 33 (a)
glc-1 37
  • 37 (a)
glc-2 37
  • 37 (a)
glc-3 37
  • 36 (a)
glc-4 37
  • 31 (a)
K10D6.1 37
  • 31 (a)
T20B12.9 37
  • 30 (a)
T24D8.1 37
  • 35 (a)
T27E9.9 37
  • 33 (a)
W10G11.16 37
  • 30 (a)
Y39A3B.2 37
  • 36 (a)
Y71D11A.5 37
  • 29 (a)
Y73F8A.2 37
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 60 (a)
OneToMany
Species with no ortholog for GLRA3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GLRA3 Gene

ENSEMBL:
Gene Tree for GLRA3 (if available)
TreeFam:
Gene Tree for GLRA3 (if available)

Paralogs for GLRA3 Gene

genes like me logo Genes that share paralogs with GLRA3: view

Variants for GLRA3 Gene

Sequence variations from dbSNP and Humsavar for GLRA3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs25400 -- 174,682,438(+) AATTT(A/T)AAAAA intron-variant
rs952561 -- 174,826,376(+) TTATA(G/T)AAGTC intron-variant
rs959368 -- 174,762,650(+) TCACC(A/G)AATAG intron-variant
rs1352055 -- 174,770,348(+) ATAAT(A/G)TGCAA intron-variant
rs1564939 -- 174,730,348(-) GGTCA(A/G)TCACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GLRA3 Gene

Variant ID Type Subtype PubMed ID
nsv880584 CNV Loss 21882294
esv988593 CNV Deletion 20482838
esv2672036 CNV Deletion 23128226
dgv911n67 CNV Loss 20364138
nsv821054 CNV Deletion 20802225
esv2728767 CNV Deletion 23290073
esv9678 CNV Loss 19470904
dgv993e199 CNV Deletion 23128226
esv22642 CNV Gain 19812545
esv1917201 CNV Deletion 18987734
nsv830156 CNV Gain 17160897
nsv507220 CNV Insertion 20534489

Variation tolerance for GLRA3 Gene

Residual Variation Intolerance Score: 28.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.13; 22.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GLRA3 Gene

HapMap Linkage Disequilibrium report
GLRA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLRA3 Gene

Disorders for GLRA3 Gene

Relevant External Links for GLRA3

Genetic Association Database (GAD)
GLRA3
Human Genome Epidemiology (HuGE) Navigator
GLRA3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GLRA3

No disorders were found for GLRA3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GLRA3 Gene

Publications for GLRA3 Gene

  1. The human glycine receptor subunit alpha3. GLRA3 gene structure, chromosomal localization, and functional characterization of alternative transcripts. (PMID: 9677400) Nikolic Z. … Becker C.-M. (J. Biol. Chem. 1998) 2 3 4 23 67
  2. Dual actions of lindane (I^-hexachlorocyclohexane) on calcium homeostasis and exocytosis in rat PC12 cells. (PMID: 20600211) Heusinkveld H.J. … Westerink R.H. (Toxicol. Appl. Pharmacol. 2010) 25 26
  3. Novel regulatory site within the TM3-4 loop of human recombinant alpha3 glycine receptors determines channel gating and domain structure. (PMID: 19661067) Breitinger H.G. … Becker C.M. (J. Biol. Chem. 2009) 3 23
  4. An ivermectin-sensitive glutamate-gated chloride channel from the parasitic nematode Haemonchus contortus. (PMID: 19336526) McCavera S. … Wolstenholme A.J. (Mol. Pharmacol. 2009) 25 26
  5. Glycine receptors of A-type ganglion cells of the mouse retina. (PMID: 17550639) Majumdar S. … WAossle H. (Vis. Neurosci. 2007) 25 26

Products for GLRA3 Gene

Sources for GLRA3 Gene

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