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GLRA3 Gene

protein-coding   GIFtS: 62
GCID: GC04M175558

Glycine Receptor, Alpha 3

  See GLRA3-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Glycine Receptor, Alpha 31 2
Glycine Receptor Subunit Alpha-32
Glycine Receptor, Alpha-3 Polypeptide2
Ligand Gated Ion Channel2

External Ids:    HGNC: 43281   Entrez Gene: 80012   Ensembl: ENSG000001454517   OMIM: 6004215   UniProtKB: O753113   

Export aliases for GLRA3 gene to outside databases

Previous GC identifers: GC04M176484 GC04M176102 GC04M176259 GC04M175938 GC04M175800 GC04M171312


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GLRA3 Gene:
This gene encodes a member of the ligand-gated ion channel protein family. The encoded protein is a member of the
glycine receptor subfamily. Alternative splicing results in multiple transcript variants. (provided by RefSeq,
Nov 2013)

GeneCards Summary for GLRA3 Gene:
GLRA3 (glycine receptor, alpha 3) is a protein-coding gene. Diseases associated with GLRA3 include hyperekplexia. GO annotations related to this gene include extracellular-glycine-gated chloride channel activity and extracellular ligand-gated ion channel activity. An important paralog of this gene is GLRA2.

UniProtKB/Swiss-Prot: GLRA3_HUMAN, O75311
Function: The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor
increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing)

summary for GLRA3 Gene:
Glycine receptors (GlyR) are members of the cys-loop family of ligand-gated ion channels, responsible for
mediating the inhibitory effects of glycine. They are widely distributed throughout the CNS, particularly
within the hippocampus, spinal cord and brain stem. Glycine receptors exist as pentameric proteins,
homo-oligomers of the alpha isoforms (alpha1, alpha2, alpha3 or alpha4) or hetero-oligomers which also
contain the beta-subtype variant (beta1) which is essential for targeting the receptor to the synapse.
Glycine receptors contain an integral chloride channel, and have modulatory sites for anesthetics,
neurosteroids, cannabinoids and ethanol. Disruption in glycine receptor expression or ion channel function
can result in hyperekplexia, a rare neurological disorder.

Gene Wiki entry for GLRA3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the GLRA3 gene promoter:
         POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   CBF-C   C/EBPalpha   HEN1   Egr-2   POU2F1   POU2F1a   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGLRA3 promoter sequence
   Search Chromatin IP Primers for GLRA3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GLRA3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q34.1   Ensembl cytogenetic band:  4q34.1   HGNC cytogenetic band: 4q34.1

GLRA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GLRA3 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M175558:  view genomic region     (about GC identifiers)

Start:
175,558,065 bp from pter      End:
175,750,465 bp from pter
Size:
192,401 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GLRA3_HUMAN, O75311 (See protein sequence)
Recommended Name: Glycine receptor subunit alpha-3 precursor  
Size: 464 amino acids; 53800 Da
Subunit: Pentamer composed of alpha and beta subunits (By similarity)
Miscellaneous: The alpha subunit binds strychnine
Secondary accessions: D3DP44 O75816 Q5D0E3
Alternative splicing: 2 isoforms:  O75311-1   O75311-2   

Explore the universe of human proteins at neXtProt for GLRA3: NX_O75311

Explore proteomics data for GLRA3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn71
  • Modification sites at PhosphoSitePlus

  • See GLRA3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001036008.1  NP_006520.2  

    ENSEMBL proteins: 
     ENSP00000274093   ENSP00000345284  
    Reactome Protein details: O75311

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GLRA: Ligand-gated ion channels / Glycine receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: alpha3
    Glycine receptors

    Selected InterPro protein domains (see all 7):
     IPR008130 Glycine_rcpt_A3
     IPR008127 Glycine_rcpt_A
     IPR018000 Neurotransmitter_ion_chnl_CS
     IPR006028 GABAA_rcpt
     IPR006201 Neur_channel

    Graphical View of Domain Structure for InterPro Entry O75311

    ProtoNet protein and cluster: O75311

    3 Blocks protein domains:
    IPB006028 Gamma-aminobutyric acid A (GABAA) receptor signature
    IPB006201 Neurotransmitter-gated ion-channel
    IPB008130 Glycine receptor alpha 3 subunit signature


    UniProtKB/Swiss-Prot: GLRA3_HUMAN, O75311
    Domain: The N-terminal domain carries structural determinants essential for agonist and antagonist binding. TM2 is
    thought to form the innert wall of the chloride channel. The cytoplasmic loop is an important determinant of
    channel inactivation kinetics
    Similarity: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily.
    GLRA3 sub-subfamily


    Find genes that share domains with GLRA3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GLRA3_HUMAN, O75311
    Function: The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor
    increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing)

         Genatlas biochemistry entry for GLRA3:
    glycine receptor,alpha 3 subunit expressed in the central nervous system,with two splice variants GLRA3L,GLRA3K

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005230extracellular ligand-gated ion channel activity ----
    GO:0016594glycine binding IEA--
    GO:0016934extracellular-glycine-gated chloride channel activity IEA--
    GO:0022824transmitter-gated ion channel activity IEA--
         
    Find genes that share ontologies with GLRA3           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Glra3):
     behavior/neurological  integument  nervous system  no phenotypic analysis  vision/eye 

    Find genes that share phenotypes with GLRA3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Glra3tm1.1Umu for GLRA3

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    SwitchGear 3'UTR luciferase reporter plasmidGLRA3 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GLRA3_HUMAN, O75311: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell
    membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----
    GO:0030054cell junction IEA--

    Find genes that share ontologies with GLRA3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GLRA3 About    
    See pathways by source

    SuperPathContained pathways About
    1Ion channel transport
    Ion channel transport0.58
    2Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Transmembrane transport of small molecules0.47
    3Ca-dependent events
    Neurophysiological process PGE2 induced pain processing0.38
    4Peptide ligand-binding receptors
    Neuroactive ligand-receptor interaction0.36
    5Ligand-gated ion channel transport
    Ligand-gated ion channel transport


    Find genes that share SuperPaths with GLRA3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for GLRA3
        Neurophysiological process PGE2-induced pain processing


    1 Reactome Pathway for GLRA3
        Ligand-gated ion channel transport


    1 Kegg Pathway  (Kegg details for GLRA3):
        Neuroactive ligand-receptor interaction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GLRA3
    Interactions:

        Search GeneGlobe Interaction Network for GLRA3

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5 Interacting proteins for GLRA3 (O753113 ENSP000002740934) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NDRG3Q9UGV23I2D: score=1 
    GLRA1ENSP000002745764STRING: ENSP00000274576
    GLRA2ENSP000002180754STRING: ENSP00000218075
    GLRBENSP000002644284STRING: ENSP00000264428
    GPHNENSP000003030194STRING: ENSP00000303019
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0006811ion transport ----
    GO:0007268synaptic transmission ----
    GO:0034220ion transmembrane transport TAS--
    GO:0055085transmembrane transport TAS--

    Find genes that share ontologies with GLRA3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Compounds for GLRA3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    beta-Alanine Endogenous glycine agonist, more selective than taurine (Cat. No. 0209) [107-95-9]
    HypotaurineNon-selective endogenous glycine receptor agonist[300-84-5]
    L-SerineWeak endogenous glycine receptor agonist[56-45-1]
    L-AlanineGlycine receptor agonist[56-41-7]
    Taurine Non-selective, endogenous glycine receptor partial agonist [107-35-7]

    2 HMDB Compounds for GLRA3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ChlorineCl2 (see all 13)16887-00-6--
    Glycine2-Aminoacetate (see all 15)56-40-6--

    4 DrugBank Compounds for GLRA3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Ivermectin22,23-Dihydroxy-avermectin B (see all 3)70288-86-7targetagonist19336526 17016423 15313134 10592235
    Glycine2-Aminoacetic acid (see all 4)56-40-6target--17550639 17154252
    LindaneBenzene hexachloride (see all 11)58-89-9targetantagonist20600211 12614680
    Picrotoxin-- 124-87-8targetantagonist17714449

    Selected IUPHAR Ligands for GLRA3 (alpha3) (see all 14)    About this table
    LigandTypeActionAffinityPubmed IDs
    HU-210
    AntagonistAntagonist7.3--
    WIN55212-2
    AntagonistAntagonist7--
    HU-308
    AntagonistAntagonist7--
    picrotoxinin
    Channel blockerNone6.4--
    ginkgolide B
    Channel blockerNone5.7--
    Delta9-tetrahydrocannabinol
    Allosteric regulatorPotentiation5.3--
    (12E,20Z,18S)-8-hydroxyvariabilin
    AntagonistAntagonist5.2--
    picrotin
    Channel blockerNone5.2--
    Cu2+
    Allosteric regulatorInhibition5--
    nifedipine
    AntagonistAntagonist4.5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GLRA3 gene (2 alternative transcripts): 
    NM_001042543.2  NM_006529.3  

    Unigene Cluster for GLRA3:

    Glycine receptor, alpha 3
    Hs.413099  [show with all ESTs]
    Unigene Representative Sequence: NM_006529
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000274093(uc003ity.1 uc003itz.1) ENST00000340217 ENST00000483010
    ENST00000436738
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    Additional mRNA sequence: 

    AF018157.1 BC036086.1 U93917.1 

    4 DOTS entries:

    DT.91699388  DT.91699381  DT.100745272  DT.99962581 

    22 AceView cDNA sequences:

    AA283885 AW298713 AA283884 U93917 BG193387 AA872485 AA489056 AI761703 
    BC036086 BI825190 NM_006529 BX091928 AW297385 BG203115 AF018157 BI600831 
    AA488804 BG189196 BG196871 BG186165 BE830616 BE830621 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GLRA3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    GLRA3 Expression
    About this image

    GLRA3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GLRA3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.413099

    UniProtKB/Swiss-Prot: GLRA3_HUMAN, O75311
    Tissue specificity: Widely distributed throughout the central nervous system

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GLRA3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for GLRA3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Glra31 , 5 glycine receptor, alpha 3 subunit1, 5 89.44(n)1
    98.92(a)1
      8 (29.69 cM)5
    1103041  NM_080438.21  NP_536686.21 
     559404605 
    chicken
    (Gallus gallus)
    Aves GLRA31 glycine receptor, alpha 3 80.49(n)
    90.71(a)
      422568  XM_420527.2  XP_420527.2 
    lizard
    (Anolis carolinensis)
    Reptilia GLRA36
    glycine receptor, alpha 3
    90(a)
    1 ↔ 1
    3(143681016-143802968)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia glra31 glycine receptor, alpha 3 80.58(n)
    93.53(a)
      100488938  XM_002933325.2  XP_002933371.1 
    zebrafish
    (Danio rerio)
    Actinopterygii glra31 glycine receptor, alpha 3 74.19(n)
    88.14(a)
      192124  NM_152965.1  NP_694497.1 
    worm
    (Caenorhabditis elegans)
    Secernentea avr-143
    glc-21
    Expression: neurons, nerve ring,
    ventral cord more3
    glc-21
    38(a)
    (best of 22)3
    50.58(n)1
    43.73(a)1
      I(5975551-5981456)3
    1721031  NM_059069.31  NP_491470.11 


    ENSEMBL Gene Tree for GLRA3 (if available)
    TreeFam Gene Tree for GLRA3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GLRA3 gene
    GLRA22  GABRR12  GLRA12  GLRB2  GABRB12  GABRR32  GABRD2  GLRA42  
    GABRP2  GABRB32  GABRB22  GABRQ2  GABRR22  
    Selected SIMAP similar genes for GLRA3 using alignment to 3 protein entries:     GLRA3_HUMAN (see all proteins) (see all similar genes):
    GLRA1    GLRA2    GLRA4    GABRP    GABRG3    GABRQ
    GABRA6    GABRE    GABRR3    GABRR2    GLRB    GABRA5
    GABRR1    GABRA2    GABRG2    GABRD    GABRB3    GABRA4

    Find genes that share paralogs with GLRA3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GLRA3 (see all 4022)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs715954331,2
    C--175449785(+) CATTT-/AC/   
      ACACAC
    ACACA
    2 -- int11NA 2
    rs105592991,2
    C--175463122(+) GGAAT-/GTCTAGA 2 -- int11Minor allele frequency- GT:0.00NA 2
    rs1870778711,2
    --175562734(+) ACCAAC/TGTCCT 2 -- ds50010--------
    rs41323741,2
    C,F,A,H--175562808(+) CATTTT/ATAATA 2 -- ds500115Minor allele frequency- A:0.43NA NS EA WA CSA 928
    rs102131031,2
    C,F,H--175562962(+) AAAACG/TTATTC 2 -- ds500112Minor allele frequency- T:0.04NS NA WA 1612
    rs1167401601,2
    F--175562995(+) GATGAT/AGTAGT 2 -- ds50011Minor allele frequency- A:0.03WA 118
    rs1465027641,2
    --175563010(+) AATTAC/TCTCAA 2 -- ds50010--------
    rs1915617631,2
    --175563042(+) GAATAC/TAAATG 2 -- ds50010--------
    rs1399713141,2
    --175563094(+) TGGTTC/TTGTTA 2 -- ds50010--------
    rs113207591,2
    C--175563485(+) TTCTTA/-ATCTT 2 -- ut312Minor allele frequency- -:0.00NA 4

    HapMap Linkage Disequilibrium report for GLRA3 (175558065 - 175750465 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for GLRA3 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv821054CNV Deletion20802225
    dgv993e199CNV Deletion23128226
    esv2672036CNV Deletion23128226
    esv988593CNV Deletion20482838
    esv2728767CNV Deletion23290073
    esv1917201CNV Deletion18987734
    nsv507220CNV Insertion20534489
    esv9678CNV Loss19470904
    dgv911n67CNV Loss20364138
    nsv880584CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GLRA3
    DNA2.0 Custom Variant and Variant Library Synthesis for GLRA3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600421    OMIM disorders: --

    1 disease for GLRA3:    
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    hyperekplexia


    Find genes that share disorders with GLRA3           About GenesLikeMe

    Genetic Association Database (GAD): GLRA3
    Human Genome Epidemiology (HuGE) Navigator: GLRA3 (2 documents)

    Export disorders for GLRA3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GLRA3 gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with GLRA3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human glycine receptor subunit alpha3. GLRA3 gene structure, chromosomal localization, and functional characterization of alternative transcripts. (PubMed id 9677400)1, 2, 3, 9 Nikolic Z.... Becker C.-M. (J. Biol. Chem. 1998)
    2. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Genetic variation of the human glycine receptor subunit genes GLRA3 and GLRB and susceptibility to idiopathic generalized epilepsies. (PubMed id 11496371)1, 4 Sobetzko D....Becker C.M. (Am. J. Med. Genet. 2001)
    5. Novel regulatory site within the TM3-4 loop of human recombinant alpha3 glycine receptors determines channel gating and domain structure. (PubMed id 19661067)1, 9 Breitinger H.G....Becker C.M. (J. Biol. Chem. 2009)
    6. Hydroxylated residues influence desensitization behaviour of recombinant alpha3 glycine receptor channels. (PubMed id 12358726)1, 9 Breitinger H.G....Becker C.M. (J. Neurochem. 2002)
    7. Dual actions of lindane (I^-hexachlorocyclohexane) on calcium homeostasis and exocytosis in rat PC12 cells. (PubMed id 20600211)7 Heusinkveld H.J....Westerink R.H. (Toxicol. Appl. Pharmacol. 2010)
    8. Multifunctional basic motif in the glycine receptor intracellular domain induces subunit-specific sorting. (PubMed id 19959465)1 Melzer N....Becker C.M. (J. Biol. Chem. 2010)
    9. An ivermectin-sensitive glutamate-gated chloride channel from the parasitic nematode Haemonchus contortus. (PubMed id 19336526)7 McCavera S....Wolstenholme A.J. (Mol. Pharmacol. 2009)
    10. A proposed structural basis for picrotoxinin and picrotin binding in the glycine receptor pore. (PubMed id 17714449)7 Yang Z....Lynch J.W. (J. Neurochem. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8001 HGNC: 4328 AceView: GLRA3 Ensembl:ENSG00000145451 euGenes: HUgn8001
    ECgene: GLRA3 Kegg: 8001 H-InvDB: GLRA3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GLRA3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GLRA3 gene:
    Search GeneIP for patents involving GLRA3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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