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Aliases for GLRA3 Gene

Aliases for GLRA3 Gene

  • Glycine Receptor Alpha 3 2 3 5

External Ids for GLRA3 Gene

Previous GeneCards Identifiers for GLRA3 Gene

  • GC04M176484
  • GC04M176102
  • GC04M176259
  • GC04M175938
  • GC04M175800
  • GC04M175558
  • GC04M171312

Summaries for GLRA3 Gene

Entrez Gene Summary for GLRA3 Gene

  • This gene encodes a member of the ligand-gated ion channel protein family. The encoded protein is a member of the glycine receptor subfamily. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

GeneCards Summary for GLRA3 Gene

GLRA3 (Glycine Receptor Alpha 3) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and DAG and IP3 signaling. Gene Ontology (GO) annotations related to this gene include extracellular ligand-gated ion channel activity and extracellularly glycine-gated chloride channel activity. An important paralog of this gene is GLRA1.

UniProtKB/Swiss-Prot for GLRA3 Gene

  • Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:9677400, PubMed:26416729). Channel characteristics depend on the subunit composition; heteropentameric channels display faster channel closure (By similarity). Plays an important role in the down-regulation of neuronal excitability (By similarity). Contributes to the generation of inhibitory postsynaptic currents (By similarity). Contributes to increased pain perception in response to increased prostaglandin E2 levels (By similarity). Plays a role in cellular responses to ethanol (By similarity).

Tocris Summary for GLRA3 Gene

  • Glycine receptors (GlyR) are members of the cys-loop family of ligand-gated ion channels, responsible for mediating the inhibitory effects of glycine. They are widely distributed throughout the CNS, particularly within the hippocampus, spinal cord and brain stem.

Gene Wiki entry for GLRA3 Gene

Additional gene information for GLRA3 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLRA3 Gene

Genomics for GLRA3 Gene

GeneHancer (GH) Regulatory Elements for GLRA3 Gene

Promoters and enhancers for GLRA3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I174828 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 550.8 -0.1 -127 1.1 HDAC1 CTCF MXI1 PKNOX1 USF1 ATF1 TEAD4 SIN3A E2F1 ZNF316 ADAM29 GLRA3
GH04I174681 Enhancer 1.2 FANTOM5 ENCODE 0.1 +147.5 147458 1.2 PKNOX1 ATF1 ARNT NCOA2 TCF12 ZNF766 GATA2 FOS ATF7 NCOA1 HPGD GC04P174661 GC04M174697 GLRA3
GH04I174662 Enhancer 0.4 FANTOM5 0.1 +166.6 166582 0.2 FOSL1 L3MBTL2 GC04P174661 HPGD GC04M174697 GLRA3
GH04I174626 Enhancer 0.2 ENCODE 0.1 +202.5 202480 1.1 HPGD LOC105377551 LOC105377549 GLRA3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GLRA3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GLRA3 gene promoter:

Genomic Locations for GLRA3 Gene

Genomic Locations for GLRA3 Gene
chr4:174,624,141-174,829,315
(GRCh38/hg38)
Size:
205,175 bases
Orientation:
Minus strand
chr4:175,558,065-175,750,465
(GRCh37/hg19)

Genomic View for GLRA3 Gene

Genes around GLRA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GLRA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GLRA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLRA3 Gene

Proteins for GLRA3 Gene

  • Protein details for GLRA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75311-GLRA3_HUMAN
    Recommended name:
    Glycine receptor subunit alpha-3
    Protein Accession:
    O75311
    Secondary Accessions:
    • D3DP44
    • O75816
    • Q5D0E3

    Protein attributes for GLRA3 Gene

    Size:
    464 amino acids
    Molecular mass:
    53800 Da
    Quaternary structure:
    • Homopentamer (in vitro) (PubMed:26416729). Heteropentamer composed of GLRA3 and GLRB. Both homopentamers and heteropentamers form functional ion channels, but their characteristics are subtly different (By similarity).
    Miscellaneous:
    • The alpha subunit binds strychnine.

    Three dimensional structures from OCA and Proteopedia for GLRA3 Gene

    Alternative splice isoforms for GLRA3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GLRA3 Gene

Post-translational modifications for GLRA3 Gene

Other Protein References for GLRA3 Gene

No data available for DME Specific Peptides for GLRA3 Gene

Domains & Families for GLRA3 Gene

Gene Families for GLRA3 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • Predicted membrane proteins
  • Transporters

Suggested Antigen Peptide Sequences for GLRA3 Gene

Graphical View of Domain Structure for InterPro Entry

O75311

UniProtKB/Swiss-Prot:

GLRA3_HUMAN :
  • The N-terminal domain carries structural determinants essential for agonist and antagonist binding. The channel pore is formed by pentameric assembly of the second transmembrane domain from all five subunits (PubMed:26416729). The cytoplasmic loop is an important determinant of channel inactivation kinetics.
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA3 sub-subfamily.
Domain:
  • The N-terminal domain carries structural determinants essential for agonist and antagonist binding. The channel pore is formed by pentameric assembly of the second transmembrane domain from all five subunits (PubMed:26416729). The cytoplasmic loop is an important determinant of channel inactivation kinetics.
Family:
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA3 sub-subfamily.
genes like me logo Genes that share domains with GLRA3: view

Function for GLRA3 Gene

Molecular function for GLRA3 Gene

GENATLAS Biochemistry:
glycine receptor,alpha 3 subunit expressed in the central nervous system,with two splice variants GLRA3L,GLRA3K
UniProtKB/Swiss-Prot Function:
Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:9677400, PubMed:26416729). Channel characteristics depend on the subunit composition; heteropentameric channels display faster channel closure (By similarity). Plays an important role in the down-regulation of neuronal excitability (By similarity). Contributes to the generation of inhibitory postsynaptic currents (By similarity). Contributes to increased pain perception in response to increased prostaglandin E2 levels (By similarity). Plays a role in cellular responses to ethanol (By similarity).

Phenotypes From GWAS Catalog for GLRA3 Gene

Gene Ontology (GO) - Molecular Function for GLRA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0005230 extracellular ligand-gated ion channel activity IEA --
GO:0005254 chloride channel activity IEA --
GO:0016594 contributes_to glycine binding IBA --
GO:0016934 extracellularly glycine-gated chloride channel activity IDA 26416729
genes like me logo Genes that share ontologies with GLRA3: view
genes like me logo Genes that share phenotypes with GLRA3: view

Animal Models for GLRA3 Gene

MGI Knock Outs for GLRA3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GLRA3 Gene

Localization for GLRA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLRA3 Gene

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Perikaryon. Cell projection, dendrite. Cell junction, synapse. Cell membrane; Multi-pass membrane protein. Note=Partially colocalizes with GPHN that is known to mediate receptor clustering at postsynaptic membranes. {ECO:0000250 UniProtKB:P24524}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GLRA3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GLRA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IMP 9677400
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0016935 glycine-gated chloride channel complex IDA 9677400
genes like me logo Genes that share ontologies with GLRA3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GLRA3 Gene

Pathways & Interactions for GLRA3 Gene

genes like me logo Genes that share pathways with GLRA3: view

Pathways by source for GLRA3 Gene

Gene Ontology (GO) - Biological Process for GLRA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006821 chloride transport IEA --
GO:0007218 neuropeptide signaling pathway IBA --
GO:0007268 chemical synaptic transmission TAS --
genes like me logo Genes that share ontologies with GLRA3: view

No data available for SIGNOR curated interactions for GLRA3 Gene

Drugs & Compounds for GLRA3 Gene

(22) Drugs for GLRA3 Gene - From: DrugBank, DGIdb, IUPHAR, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ivermectin Approved, Investigational, Vet_approved Pharma Target, agonist NAChR/purinergic P2X4 receptor modulator 70
Lindane Approved, Withdrawn Pharma Target, antagonist 0
Glycine Approved, Vet_approved Nutra Full agonist, Agonist, Target 254
Taurine Approved Nutra Target, agonist Non-selective, endogenous glycine receptor partial agonist 31
Nifedipine Approved Pharma Antagonist, Gating inhibitor, blocker 123

(2) Additional Compounds for GLRA3 Gene - From: IUPHAR and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Delta<sup>9</sup>-tetrahydrocannabinol
Partial agonist, Agonist
Chloride ion
  • Bertholite
  • Chloor
  • Chlor
  • Chlore
  • Chloride
16887-00-6

(5) Tocris Compounds for GLRA3 Gene

Compound Action Cas Number
beta-Alanine Endogenous glycine agonist, more selective than taurine (Cat. No. 0209) 107-95-9
Hypotaurine Non-selective endogenous glycine receptor agonist 300-84-5
L-Alanine Glycine receptor agonist 56-41-7
L-Serine Weak endogenous glycine receptor agonist 56-45-1
Taurine Non-selective, endogenous glycine receptor partial agonist 107-35-7
genes like me logo Genes that share compounds with GLRA3: view

Transcripts for GLRA3 Gene

Unigene Clusters for GLRA3 Gene

Glycine receptor, alpha 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for GLRA3 Gene

No ASD Table

Relevant External Links for GLRA3 Gene

GeneLoc Exon Structure for
GLRA3
ECgene alternative splicing isoforms for
GLRA3

Expression for GLRA3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GLRA3 Gene

mRNA differential expression in normal tissues according to GTEx for GLRA3 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x8.4), Brain - Anterior cingulate cortex (BA24) (x8.3), Brain - Hypothalamus (x7.3), Brain - Cortex (x6.1), and Brain - Substantia nigra (x4.2).

Protein differential expression in normal tissues from HIPED for GLRA3 Gene

This gene is overexpressed in Retina (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GLRA3 Gene



Protein tissue co-expression partners for GLRA3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GLRA3 Gene:

GLRA3

SOURCE GeneReport for Unigene cluster for GLRA3 Gene:

Hs.413099

mRNA Expression by UniProt/SwissProt for GLRA3 Gene:

O75311-GLRA3_HUMAN
Tissue specificity: Widely distributed throughout the central nervous system.

Evidence on tissue expression from TISSUES for GLRA3 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with GLRA3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for GLRA3 Gene

Orthologs for GLRA3 Gene

This gene was present in the common ancestor of animals.

Orthologs for GLRA3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GLRA3 33 34
  • 99.57 (n)
oppossum
(Monodelphis domestica)
Mammalia GLRA3 34
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GLRA3 34
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GLRA3 33 34
  • 93.47 (n)
cow
(Bos Taurus)
Mammalia GLRA3 33 34
  • 91.85 (n)
mouse
(Mus musculus)
Mammalia Glra3 33 16 34
  • 89.44 (n)
rat
(Rattus norvegicus)
Mammalia Glra3 33
  • 88.79 (n)
chicken
(Gallus gallus)
Aves GLRA3 33 34
  • 80.49 (n)
lizard
(Anolis carolinensis)
Reptilia GLRA3 34
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia glra3 33
  • 80.58 (n)
zebrafish
(Danio rerio)
Actinopterygii GLRA3 34
  • 75 (a)
OneToOne
glra3 33
  • 74.19 (n)
fruit fly
(Drosophila melanogaster)
Insecta Grd 35
  • 47 (a)
Rdl 35
  • 46 (a)
ort 35
  • 43 (a)
GluClalpha 35
  • 40 (a)
CG11340 35
  • 32 (a)
CG6927 35
  • 31 (a)
CG7589 35
  • 25 (a)
worm
(Caenorhabditis elegans)
Secernentea glc-2 35 33
  • 50.58 (n)
avr-14 35
  • 38 (a)
C39B10.2 35
  • 37 (a)
glc-1 35
  • 37 (a)
F11H8.2 35
  • 36 (a)
gbr-4 35
  • 36 (a)
gbr-5 35
  • 36 (a)
glc-3 35
  • 36 (a)
Y39A3B.2 35
  • 36 (a)
F55D10.5 35
  • 35 (a)
T24D8.1 35
  • 35 (a)
C53D6.3 35
  • 33 (a)
gbr-6 35
  • 33 (a)
T27E9.9 35
  • 33 (a)
glc-4 35
  • 31 (a)
K10D6.1 35
  • 31 (a)
T20B12.9 35
  • 30 (a)
W10G11.16 35
  • 30 (a)
F09G2.5 35
  • 29 (a)
F58G6.4 35
  • 29 (a)
Y71D11A.5 35
  • 29 (a)
Y73F8A.2 35
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 60 (a)
OneToMany
Species where no ortholog for GLRA3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GLRA3 Gene

ENSEMBL:
Gene Tree for GLRA3 (if available)
TreeFam:
Gene Tree for GLRA3 (if available)

Paralogs for GLRA3 Gene

genes like me logo Genes that share paralogs with GLRA3: view

Variants for GLRA3 Gene

Sequence variations from dbSNP and Humsavar for GLRA3 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000003644 -- 174,706,043(-) C/A intron_variant
rs1000020521 -- 174,824,861(-) T/A genic_upstream_transcript_variant, intron_variant
rs10000456 -- 174,728,790(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000061229 -- 174,751,955(-) A/C genic_upstream_transcript_variant, intron_variant
rs1000073360 -- 174,747,115(-) G/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GLRA3 Gene

Variant ID Type Subtype PubMed ID
dgv911n67 CNV loss 20364138
dgv9398n54 CNV loss 21841781
dgv9399n54 CNV loss 21841781
dgv9400n54 CNV loss 21841781
dgv9401n54 CNV loss 21841781
dgv9402n54 CNV loss 21841781
dgv993e199 CNV deletion 23128226
esv1917201 CNV deletion 18987734
esv22642 CNV gain 19812545
esv2672036 CNV deletion 23128226
esv2728767 CNV deletion 23290073
esv3297162 CNV deletion 24192839
esv3565040 CNV deletion 23714750
esv3603233 CNV loss 21293372
esv3603234 CNV loss 21293372
esv3603236 CNV gain 21293372
esv3603237 CNV gain 21293372
esv9678 CNV loss 19470904
esv988593 CNV deletion 20482838
nsv1027622 CNV gain 25217958
nsv1072043 CNV deletion 25765185
nsv1139328 CNV deletion 24896259
nsv1139329 CNV deletion 24896259
nsv507220 OTHER sequence alteration 20534489
nsv596235 CNV loss 21841781
nsv821054 CNV deletion 20802225
nsv830156 CNV gain 17160897
nsv967816 CNV duplication 23825009

Variation tolerance for GLRA3 Gene

Residual Variation Intolerance Score: 28.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.13; 22.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GLRA3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GLRA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLRA3 Gene

Disorders for GLRA3 Gene

Additional Disease Information for GLRA3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for GLRA3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GLRA3 Gene

Publications for GLRA3 Gene

  1. The human glycine receptor subunit alpha3. Glra3 gene structure, chromosomal localization, and functional characterization of alternative transcripts. (PMID: 9677400) Nikolic Z … Becker CM (The Journal of biological chemistry 1998) 2 3 4 22 58
  2. Crystal structure of human glycine receptor-α3 bound to antagonist strychnine. (PMID: 26416729) Huang X … Shaffer PL (Nature 2015) 3 4 58
  3. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PMID: 19086053) Gratacòs M … Psychiatric Genetics Network Group (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2009) 3 44 58
  4. Novel regulatory site within the TM3-4 loop of human recombinant alpha3 glycine receptors determines channel gating and domain structure. (PMID: 19661067) Breitinger HG … Becker CM (The Journal of biological chemistry 2009) 3 22 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for GLRA3 Gene

Sources for GLRA3 Gene

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