Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GLRA3 Gene

protein-coding   GIFtS: 62
GCID: GC04M175558

Glycine Receptor, Alpha 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Glycine Receptor, Alpha 31 2
Glycine Receptor Alpha 3 Subunit2
Glycine Receptor Subunit Alpha-32
Glycine Receptor, Alpha-3 Polypeptide2
Ligand Gated Ion Channel2

External Ids:    HGNC: 43281   Entrez Gene: 80012   Ensembl: ENSG000001454517   OMIM: 6004215   UniProtKB: O753113   

Export aliases for GLRA3 gene to outside databases

Previous GC identifers: GC04M176484 GC04M176102 GC04M176259 GC04M175938 GC04M175800 GC04M171312


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GLRA3 Gene:
The GLRA3 gene encodes the alpha-3 subunit of the neuronal glycine receptor, a ligand-gated chloride channel
composed of ligand-binding alpha and structural beta polypeptides (Kingsmore et al., 1994 (PubMed
7894176)).(supplied by OMIM, Nov 2009)

GeneCards Summary for GLRA3 Gene: 
GLRA3 (glycine receptor, alpha 3) is a protein-coding gene. Diseases associated with GLRA3 include hyperekplexia, and idiopathic generalized epilepsy, and among its related super-pathways are SLC-mediated transmembrane transport and Stimuli-sensing channels. GO annotations related to this gene include extracellular-glycine-gated chloride channel activity and extracellular ligand-gated ion channel activity. An important paralog of this gene is GLRA2.

UniProtKB/Swiss-Prot: GLRA3_HUMAN, O75311
Function: The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor
increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing)

summary for GLRA3 Gene:
Glycine receptors (GlyR) are members of the cys-loop family of ligand-gated ion channels, responsible for
mediating the inhibitory effects of glycine. They are widely distributed throughout the CNS, particularly
within the hippocampus, spinal cord and brain stem. Glycine receptors exist as pentameric proteins,
homo-oligomers of the alpha isoforms (alpha1, alpha2, alpha3 or alpha4) or hetero-oligomers which also
contain the beta-subtype variant (beta1) which is essential for targeting the receptor to the synapse.
Glycine receptors contain an integral chloride channel, and have modulatory sites for anesthetics,
neurosteroids, cannabinoids and ethanol. Disruption in glycine receptor expression or ion channel function
can result in hyperekplexia, a rare neurological disorder.

Gene Wiki entry for GLRA3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_016354.19  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GLRA3 gene promoter:
         POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   CBF-C   C/EBPalpha   HEN1   Egr-2   POU2F1   POU2F1a   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGLRA3 promoter sequence
   Search SABiosciences Chromatin IP Primers for GLRA3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GLRA3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q34.1   Ensembl cytogenetic band:  4q34.1   HGNC cytogenetic band: 4q34.1

GLRA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GLRA3 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M175558:  view genomic region     (about GC identifiers)

Start:
175,558,065 bp from pter      End:
175,750,465 bp from pter
Size:
192,401 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GLRA3_HUMAN, O75311 (See protein sequence)
Recommended Name: Glycine receptor subunit alpha-3 precursor  
Size: 464 amino acids; 53800 Da
Subunit: Pentamer composed of alpha and beta subunits (By similarity)
Subcellular location: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell
membrane; Multi-pass membrane protein
Miscellaneous: The alpha subunit binds strychnine
Secondary accessions: D3DP44 O75816 Q5D0E3
Alternative splicing: 2 isoforms:  O75311-1   O75311-2   

Explore the universe of human proteins at neXtProt for GLRA3: NX_O75311

Explore proteomics data for GLRA3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O75311

  • GLRA3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GLRA3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001036008.1  NP_006520.2  

    ENSEMBL proteins: 
     ENSP00000274093   ENSP00000345284  
    Reactome Protein details: O75311
    Human Recombinant Protein Products for GLRA3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for GLRA3
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for GLRA3
    GenScript Custom Purified and Recombinant Proteins Services for GLRA3
    Novus Biologicals GLRA3 Protein
    Novus Biologicals GLRA3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral to membrane NAS--
    GO:0030054cell junction IEA--

    GLRA3 for ontologies           About GeneDecksing



    GLRA3 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of GLRA3
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for GLRA3
    GenScript Custom Superior Antibodies Services for GLRA3
    Novus Biologicals GLRA3 Antibodies
    Abcam antibodies for GLRA3
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for GLRA3
    LSBio Antibodies in human, mouse, rat for GLRA3 

    Assay Products for GLRA3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for GLRA3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GLRA3
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    GLRA: Ligand-gated ion channels / Glycine receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: α3 
    Glycine receptors

    5/7 InterPro protein domains (see all 7):
     IPR008130 Glycine_rcpt_A3
     IPR008127 Glycine_rcpt_A
     IPR018000 Neurotransmitter_ion_chnl_CS
     IPR006028 GABAA_rcpt
     IPR006201 Neur_channel

    Graphical View of Domain Structure for InterPro Entry O75311

    ProtoNet protein and cluster: O75311

    3 Blocks protein domains:
    IPB006028 Gamma-aminobutyric acid A (GABAA) receptor signature
    IPB006201 Neurotransmitter-gated ion-channel
    IPB008130 Glycine receptor alpha 3 subunit signature


    UniProtKB/Swiss-Prot: GLRA3_HUMAN, O75311
    Domain: The N-terminal domain carries structural determinants essential for agonist and antagonist binding. TM2 is
    thought to form the innert wall of the chloride channel. The cytoplasmic loop is an important determinant of
    channel inactivation kinetics
    Similarity: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily.
    GLRA3 sub-subfamily


    GLRA3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GLRA3_HUMAN, O75311
    Function: The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor
    increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing)

         Genatlas biochemistry entry for GLRA3:
    glycine receptor,alpha 3 subunit expressed in the central nervous system,with two splice variants GLRA3L,GLRA3K

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005230extracellular ligand-gated ion channel activity NAS--
    GO:0016594glycine binding IEA--
    GO:0016934extracellular-glycine-gated chloride channel activity IEA--
    GO:0022824transmitter-gated ion channel activity IEA--
         
    GLRA3 for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Glra3):
     behavior/neurological  integument  nervous system  no phenotypic analysis  vision/eye 

    GLRA3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Glra3tm1.1Umu for GLRA3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for GLRA3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GLRA3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GLRA3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GLRA3 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GLRA3
    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate GLRA3 (see all 18):
    hsa-miR-320a hsa-miR-449a hsa-miR-1323 hsa-miR-3658 hsa-miR-548x hsa-miR-548c-3p hsa-miR-34c-5p hsa-miR-548am
    SwitchGear 3'UTR luciferase reporter plasmidGLRA3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for GLRA3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GLRA3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GLRA3
    Sirion Biotech Customized adenovirus for overexpression of GLRA3

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for GLRA3 (see all 11)
    OriGene ORF clones in mouse, rat for GLRA3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): GLRA3 (NM_001042543)
    Sino Biological Human cDNA Clone for GLRA3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GLRA3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GLRA3
    Sirion Biotech Customized lentivirus for stable overexpression of GLRA3 
                         Customized lentivirus expression plasmids for stable overexpression of GLRA3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GLRA3
    Search LifeMap BioReagents cell lines for GLRA3
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GLRA3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GLRA3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1SLC-mediated transmembrane transport
    Transmembrane transport of small molecules0.50
    2Ion channel transport
    Ion channel transport0.49
    3GABA A receptor activation
    Ligand-gated ion channel transport0.48
    4PKA activation in glucagon signalling
    Neurophysiological process PGE2-induced pain processing0.44
    5Class A/1 (Rhodopsin-like receptors)
    Neuroactive ligand-receptor interaction0.37

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for GLRA3
        Neurophysiological process PGE2-induced pain processing


    1 GeneGo (Thomson Reuters) Pathway for GLRA3
        Neurophysiological process PGE2-induced pain processing


    3        Reactome Pathways for GLRA3
        Ligand-gated ion channel transport
    Transmembrane transport of small molecules
    Ion channel transport


    1         Kegg Pathway  (Kegg details for GLRA3):
        Neuroactive ligand-receptor interaction


    GLRA3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GLRA3

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5 Interacting proteins for GLRA3 (O753113 ENSP000002740934) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NDRG3Q9UGV23I2D: score=1 
    GLRA1ENSP000002745764STRING: ENSP00000274576
    GLRA2ENSP000002180754STRING: ENSP00000218075
    GLRBENSP000002644284STRING: ENSP00000264428
    GPHNENSP000003030194STRING: ENSP00000303019
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0006811ion transport ----
    GO:0007268synaptic transmission NAS--
    GO:0034220ion transmembrane transport TAS--
    GO:0055085transmembrane transport TAS--

    GLRA3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for GLRA3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    beta-Alanine Endogenous glycine agonist, more selective than taurine (Cat. No. 0209) [107-95-9]
    HypotaurineNon-selective endogenous glycine receptor agonist[300-84-5]
    L-SerineWeak endogenous glycine receptor agonist[56-45-1]
    L-AlanineGlycine receptor agonist[56-41-7]
    Taurine Non-selective, endogenous glycine receptor partial agonist [107-35-7]

    2 HMDB Compounds for GLRA3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ChlorineCl2 (see all 13)16887-00-6--
    Glycine2-Aminoacetate (see all 15)56-40-6--

    4 DrugBank Compounds for GLRA3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Ivermectin22,23-Dihydroxy-avermectin B (see all 3)70288-86-7targetagonist19336526 17016423 15313134 10592235
    Glycine2-Aminoacetic acid (see all 4)56-40-6target--17550639 17154252
    LindaneBenzene hexachloride (see all 11)58-89-9targetantagonist20600211 12614680
    Picrotoxin-- 124-87-8targetantagonist17714449

    10/14 IUPHAR Ligands for GLRA3 (α3) (see all 14)    About this table 
    LigandTypeActionAffinityPubmed IDs
    HU-210
    AntagonistAntagonist7.3--
    WIN55212-2
    AntagonistAntagonist7--
    HU-308
    AntagonistAntagonist7--
    picrotoxinin
    Channel blockerNone6.4--
    ginkgolide B
    Channel blockerNone5.7--
    Δ9-tetrahydrocannabinol
    Allosteric regulatorPotentiation5.3--
    (12E,20Z,18S)-8-hydroxyvariabilin
    AntagonistAntagonist5.2--
    picrotin
    Channel blockerNone5.2--
    Cu2+
    Allosteric regulatorInhibition5--
    nifedipine
    AntagonistAntagonist4.5--

    Search CenterWatch for drugs/clinical trials and news about GLRA3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GLRA3 gene (2 alternative transcripts): 
    NM_001042543.1  NM_006529.2  

    Unigene Cluster for GLRA3:

    Glycine receptor, alpha 3
    Hs.413099  [show with all ESTs]
    Unigene Representative Sequence: NM_006529
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000274093(uc003ity.1 uc003itz.1) ENST00000340217 ENST00000483010
    ENST00000436738
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GLRA3
    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate GLRA3 (see all 18):
    hsa-miR-320a hsa-miR-449a hsa-miR-1323 hsa-miR-3658 hsa-miR-548x hsa-miR-548c-3p hsa-miR-34c-5p hsa-miR-548am
    SwitchGear 3'UTR luciferase reporter plasmidGLRA3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for GLRA3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GLRA3
    Clone
    Products:
         
    OriGene clones in human, mouse for GLRA3 (see all 11)
    OriGene ORF clones in mouse, rat for GLRA3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): GLRA3 (NM_001042543)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GLRA3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GLRA3
    Sirion Biotech Customized lentivirus for stable overexpression of GLRA3 
                         Customized lentivirus expression plasmids for stable overexpression of GLRA3 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for GLRA3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GLRA3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GLRA3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GLRA3

    Additional mRNA sequence: 

    AF018157.1 BC036086.1 U93917.1 

    4 DOTS entries:

    DT.91699388  DT.100745272  DT.91699381  DT.99962581 

    22 AceView cDNA sequences:

    AA283885 AW298713 AA283884 NM_006529 AA872485 AA489056 AI761703 U93917 
    BC036086 BG193387 BX091928 BI825190 AW297385 BG203115 AF018157 BI600831 
    AA488804 BG189196 BG196871 BE830616 BE830621 BG186165 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GLRA3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    GLRA3 Expression
    About this image


    See GLRA3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GLRA3

    SOURCE GeneReport for Unigene cluster: Hs.413099

    UniProtKB/Swiss-Prot: GLRA3_HUMAN, O75311
    Tissue specificity: Widely distributed throughout the central nervous system

        SABiosciences Custom PCR Arrays for GLRA3
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for GLRA3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GLRA3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GLRA3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GLRA3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GLRA3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for GLRA3 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Glra31 , 5 glycine receptor, alpha 3 subunit1, 5 89.44(n)1
    98.92(a)1
      8 (29.69 cM)5
    1103041  NM_080438.21  NP_536686.21 
     559404605 
    chicken
    (Gallus gallus)
    Aves GLRA31 glycine receptor, alpha 3 81.51(n)
    92.62(a)
      422568  XM_420527.1  XP_420527.1 
    lizard
    (Anolis carolinensis)
    Reptilia GLRA36
    Uncharacterized protein
    90(a)
    1 ↔ 1
    3(143681016-143802968)
    zebrafish
    (Danio rerio)
    Actinopterygii glra31 glycine receptor, alpha 3 74.19(n)
    88.14(a)
      192124  NM_152965.1  NP_694497.1 
    worm
    (Caenorhabditis elegans)
    Secernentea avr-143
    glc-21
    Expression: neurons, nerve ring,
    ventral cord more3
    Protein GLC-21
    38(a)
    (best of 22)3
    50.13(n)1
    42.49(a)1
      I(5975551-5981456)3
    1721031  NM_059069.31  NP_491470.11 


    ENSEMBL Gene Tree for GLRA3 (if available)
    TreeFam Gene Tree for GLRA3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GLRA3 gene
    GLRA22  GABRR12  GLRA12  GLRB2  GABRB12  GABRD2  GABRP2  GLRA42  
    GABRB32  GABRB22  GABRQ2  GABRR22  
    18/25 SIMAP similar genes for GLRA3 using alignment to 3 protein entries:     GLRA3_HUMAN (see all proteins) (see all similar genes):
    GLRA1    GLRA2    GLRA4    GABRP    GABRG3    GABRQ
    GABRA6    GABRE    GABRR3    GABRR2    GLRB    GABRA5
    GABRR1    GABRA2    GABRG2    GABRD    GABRB3    GABRA3

    GLRA3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4022 SNPs in GLRA3 are shown (see all 4022)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs715954331,2
    C--175449785(+) CATTT-/AC/   
      ACACAC
    ACACA
    2 -- int11NA 2
    rs105592991,2
    C--175463122(+) GGAAT-/GTCTAGA 2 -- int11Minor allele frequency- GT:0.00NA 2
    rs1870778711,2
    --175562734(+) ACCAAC/TGTCCT 2 -- ds50010--------
    rs41323741,2
    C,F,A,H--175562808(+) CATTTT/ATAATA 2 -- ds500115Minor allele frequency- A:0.43NA NS EA WA CSA 928
    rs102131031,2
    C,F,H--175562962(+) AAAACG/TTATTC 2 -- ds500112Minor allele frequency- T:0.04NS NA WA 1612
    rs1167401601,2
    F--175562995(+) GATGAT/AGTAGT 2 -- ds50011Minor allele frequency- A:0.03WA 118
    rs1465027641,2
    --175563010(+) AATTAC/TCTCAA 2 -- ds50010--------
    rs1915617631,2
    --175563042(+) GAATAC/TAAATG 2 -- ds50010--------
    rs1399713141,2
    --175563094(+) TGGTTC/TTGTTA 2 -- ds50010--------
    rs113207591,2
    C--175563485(+) TTCTTA/-ATCTT 2 -- ut312Minor allele frequency- -:0.00NA 4

    HapMap Linkage Disequilibrium report for GLRA3 (175558065 - 175750465 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/12 variations for GLRA3 (see all 12):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv821054CNV Deletion20802225
    dgv993e199CNV Deletion23128226
    esv2672036CNV Deletion23128226
    esv988593CNV Deletion20482838
    esv2728767CNV Deletion23290073
    esv1917201CNV Deletion18987734
    nsv507220CNV Insertion20534489
    esv9678CNV Loss19470904
    dgv911n67CNV Loss20364138
    nsv880584CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing GLRA3
    DNA2.0 Custom Variant and Variant Library Synthesis for GLRA3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600421    OMIM disorders: --

    3 diseases for GLRA3:    About MalaCards
    hyperekplexia    idiopathic generalized epilepsy    neuronitis


    GLRA3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): GLRA3
    Human Genome Epidemiology (HuGE) Navigator: GLRA3 (2 documents)

    Export disorders for GLRA3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GLRA3 gene, integrated from 9 sources (see all 29):
    (articles sorted by number of sources associating them with GLRA3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human glycine receptor subunit alpha3. GLRA3 gene structure, chromosomal localization, and functional characterization of alternative transcripts. (PubMed id 9677400)1, 2, 3, 9 Nikolic Z.... Becker C.-M. (1998)
    2. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (2008)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Genetic variation of the human glycine receptor subun it genes GLRA3 and GLRB and susceptibility to idiopathic generalized epilepsies . (PubMed id 11496371)1, 4 Sobetzko D....Becker C.M. (2001)
    5. Novel regulatory site within the TM3-4 loop of human recombinant alpha3 glycine receptors determines channel gating and domain struc ture. (PubMed id 19661067)1, 9 Breitinger H.G....Becker C.M. (2009)
    6. Hydroxylated residues influence desensitization behaviour of recombinant alpha3 glycine receptor channels. (PubMed id 12358726)1, 9 Breitinger H.G....Becker C.M. (2002)
    7. Dual actions of lindane (I^-hexachlorocyclohexane) on calcium homeostasis and exocytosis in rat PC12 cells. (PubMed id 20600211)7 Heusinkveld H.J....Westerink R.H. (2010)
    8. Multifunctional basic motif in the glycine receptor i ntracellular domain induces subunit-specific sorting. (PubMed id 19959465)1 Melzer N....Becker C.M. (2010)
    9. An ivermectin-sensitive glutamate-gated chloride chan nel from the parasitic nematode Haemonchus contortus. (PubMed id 19336526)7 McCavera S....Wolstenholme A.J. (2009)
    10. A proposed structural basis for picrotoxinin and picrotin binding in the glycine receptor pore. (PubMed id 17714449)7 Yang Z....Lynch J.W. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8001 HGNC: 4328 AceView: GLRA3 Ensembl:ENSG00000145451 euGenes: HUgn8001
    ECgene: GLRA3 Kegg: 8001 H-InvDB: GLRA3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GLRA3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GLRA3 gene:
    Search GeneIP for patents involving GLRA3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Kits and Assays available from EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of GLRA3
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for GLRA3  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for GLRA3  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for GLRA3  
     OriGene qSTAR qPCR primer pairs in human, mouse for GLRA3   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for GLRA3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for GLRA3   OriGene Custom Protein Services for GLRA3  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GLRA3
     QIAGEN SeqTarget long-range PCR primers for resequencing GLRA3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GLRA3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GLRA3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GLRA3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GLRA3
     GenScript Custom Purified and Recombinant Proteins Services for GLRA3 GenScript cDNA clones with any tag delivered in your preferred vector for GLRA3
     GenScript Custom Assay Services for GLRA3 GenScript Custom Superior Antibodies Services for GLRA3
     GenScript Custom overexpressing Cell Line Services for GLRA3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in GLRA3 promoter
     Search Chromatin IP Primers for GLRA3
     RT2 qPCR Primer Assay in human, mouse, rat GLRA3
     Search GNC Networks for GLRA3
     SABiosciences Custom PCR Arrays for GLRA3
     Tocris compounds for GLRA3
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for GLRA3
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     GLRA3 antibodies
     GLRA3 proteins
     GLRA3 lysates
     Antibodies for GLRA3
     See all of Abcam's Antibodies, Kits and Proteins for GLRA3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for GLRA3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GLRA3
     SwitchGear 3'UTR luciferase reporter plasmids for GLRA3
     SwitchGear Promoter luciferase reporter plasmids for GLRA3
     ThermoFisher Antibodies for GLRA3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GLRA3
     inGenious Targeting Laboratory - Custom generated mouse model solutions for GLRA3
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GLRA3
    Customized:
     lentivirus for stable overexpression of GLRA3
     lentivirus expression plasmids for stable overexpression of GLRA3
     adenovirus for overexpression of GLRA3
     LSBio Antibodies in human, mouse, rat for GLRA3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      GLRA3 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4