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Aliases for GLRA2 Gene

Aliases for GLRA2 Gene

  • Glycine Receptor, Alpha 2 2 3
  • Glycine Receptor, Alpha-2 Polypeptide 3
  • Glycine Receptor Alpha 2 Subunit 3
  • Glycine Receptor Subunit Alpha-2 3
  • GLR 3

External Ids for GLRA2 Gene

Previous HGNC Symbols for GLRA2 Gene

  • GLR

Previous GeneCards Identifiers for GLRA2 Gene

  • GC0XP013992
  • GC0XP013373
  • GC0XP013749
  • GC0XP013909
  • GC0XP014307
  • GC0XP012306

Summaries for GLRA2 Gene

Entrez Gene Summary for GLRA2 Gene

  • The glycine receptor consists of two subunits, alpha and beta, and acts as a pentamer. The protein encoded by this gene is an alpha subunit and can bind strychnine. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]

GeneCards Summary for GLRA2 Gene

GLRA2 (Glycine Receptor, Alpha 2) is a Protein Coding gene. Diseases associated with GLRA2 include dyscalculia and hyperekplexia. Among its related pathways are Ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include glycine binding and transmitter-gated ion channel activity. An important paralog of this gene is GABRR1.

UniProtKB/Swiss-Prot for GLRA2 Gene

  • The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing)

Tocris Summary for GLRA2 Gene

  • Glycine receptors (GlyR) are members of the cys-loop family of ligand-gated ion channels, responsible for mediating the inhibitory effects of glycine. They are widely distributed throughout the CNS, particularly within the hippocampus, spinal cord and brain stem. Glycine receptors exist as pentameric proteins, homo-oligomers of the alpha isoforms (alpha1, alpha2, alpha3 or alpha4) or hetero-oligomers which also contain the beta-subtype variant (beta1) which is essential for targeting the receptor to the synapse. Glycine receptors contain an integral chloride channel, and have modulatory sites for anesthetics, neurosteroids, cannabinoids and ethanol. Disruption in glycine receptor expression or ion channel function can result in hyperekplexia, a rare neurological disorder.

Gene Wiki entry for GLRA2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLRA2 Gene

Genomics for GLRA2 Gene

Regulatory Elements for GLRA2 Gene

Genomic Location for GLRA2 Gene

Start:
14,529,298 bp from pter
End:
14,731,812 bp from pter
Size:
202,515 bases
Orientation:
Plus strand

Genomic View for GLRA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GLRA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLRA2 Gene

Proteins for GLRA2 Gene

  • Protein details for GLRA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P23416-GLRA2_HUMAN
    Recommended name:
    Glycine receptor subunit alpha-2
    Protein Accession:
    P23416
    Secondary Accessions:
    • A8K0J6
    • B2R6I8
    • B7Z4F5
    • J3KQ59
    • Q53YX7
    • Q6ICQ0
    • Q99862

    Protein attributes for GLRA2 Gene

    Size:
    452 amino acids
    Molecular mass:
    52002 Da
    Quaternary structure:
    • Pentamer composed of alpha and beta subunits
    Miscellaneous:
    • The alpha subunit binds strychnine

    Alternative splice isoforms for GLRA2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GLRA2 Gene

Proteomics data for GLRA2 Gene at MOPED

Post-translational modifications for GLRA2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GLRA2 Gene

Antibody Products

No data available for DME Specific Peptides for GLRA2 Gene

Domains for GLRA2 Gene

Gene Families for GLRA2 Gene

HGNC:
  • GLRA :Ligand-gated ion channels / Glycine receptors
IUPHAR :

Suggested Antigen Peptide Sequences for GLRA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P23416

UniProtKB/Swiss-Prot:

GLRA2_HUMAN :
  • P23416
Family:
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA2 sub-subfamily.
genes like me logo Genes that share domains with GLRA2: view

Function for GLRA2 Gene

Molecular function for GLRA2 Gene

GENATLAS Biochemistry:
glycine receptor,alpha 2 subunit
UniProtKB/Swiss-Prot Function:
The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing)

Gene Ontology (GO) - Molecular Function for GLRA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005230 extracellular ligand-gated ion channel activity --
GO:0016594 glycine binding IDA 2155780
GO:0016934 extracellular-glycine-gated chloride channel activity IDA 2155780
GO:0022824 transmitter-gated ion channel activity IEA --
genes like me logo Genes that share ontologies with GLRA2: view
genes like me logo Genes that share phenotypes with GLRA2: view

Animal Models for GLRA2 Gene

MGI Knock Outs for GLRA2:

Animal Model Products

miRNA for GLRA2 Gene

miRTarBase miRNAs that target GLRA2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GLRA2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for GLRA2 Gene

Localization for GLRA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLRA2 Gene

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GLRA2 Gene COMPARTMENTS Subcellular localization image for GLRA2 gene
Compartment Confidence
plasma membrane 5
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GLRA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane NAS 2155780
GO:0016020 membrane --
GO:0016021 integral component of membrane --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with GLRA2: view

Pathways for GLRA2 Gene

genes like me logo Genes that share pathways with GLRA2: view

Pathways by source for GLRA2 Gene

Interacting Proteins for GLRA2 Gene

Gene Ontology (GO) - Biological Process for GLRA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0006811 ion transport IDA 2155780
GO:0007218 neuropeptide signaling pathway IDA 2155780
GO:0034220 ion transmembrane transport TAS --
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with GLRA2: view

Compounds for GLRA2 Gene

(5) Tocris Compounds for GLRA2 Gene

Compound Action Cas Number
beta-Alanine Endogenous glycine agonist, more selective than taurine (Cat. No. 0209) [107-95-9]
Hypotaurine Non-selective endogenous glycine receptor agonist [300-84-5]
L-Alanine Glycine receptor agonist [56-41-7]
L-Serine Weak endogenous glycine receptor agonist [56-45-1]
Taurine Non-selective, endogenous glycine receptor partial agonist [107-35-7]

(3) HMDB Compounds for GLRA2 Gene

Compound Synonyms Cas Number PubMed IDs
Chlorine
  • Cl2
16887-00-6
Ethanol
  • 1-Hydroxyethane
64-17-5
Glycine
  • 2-Aminoacetate
56-40-6

(4) Drugbank Compounds for GLRA2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Ethanol
  • Absolute Alcohol
64-17-5 target agonist
Glycine
  • 2-Aminoacetic acid
56-40-6 target
Lindane
  • Benzene hexachloride
58-89-9 target antagonist
Picrotoxin
124-87-8 target antagonist

(20) IUPHAR Ligand for GLRA2 Gene

Ligand Type Action Affinity Pubmed IDs
HU-210 Antagonist Antagonist 7
WIN55212-2 Antagonist Antagonist 6.7
picrotoxinin Channel blocker None 6.4
Zn2+ Channel blocker None 6
HU-308 Antagonist Antagonist 6
ginkgolide X Antagonist Antagonist 5.6
ginkgolide B Channel blocker None 5.4
bilobalide Antagonist Antagonist 5.1
picrotin Channel blocker None 4.9
tropisetron Antagonist Antagonist 4.9
Cu2+ Allosteric regulator Inhibition 4.8
cyanotriphenylborate Channel blocker None 4.7
colchicine Antagonist Antagonist 4.2
5,7-dichlorokynurenic acid Antagonist Antagonist 3.7
Delta9-tetrahydrocannabinol Channel blocker None
picrotoxin Channel blocker None
pregnenolone sulphate Activator None
PMBA Antagonist Antagonist
strychnine Antagonist Antagonist
[3H]strychnine None None

(4) Novoseek inferred chemical compound relationships for GLRA2 Gene

Compound -log(P) Hits PubMed IDs
strychnine 60.6 1
bicuculline 48.3 3
gaba 38 2
ethanol 26.2 3
genes like me logo Genes that share compounds with GLRA2: view

Transcripts for GLRA2 Gene

Unigene Clusters for GLRA2 Gene

Glycine receptor, alpha 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GLRA2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GLRA2 Gene

No ASD Table

Relevant External Links for GLRA2 Gene

GeneLoc Exon Structure for
GLRA2
ECgene alternative splicing isoforms for
GLRA2

Expression for GLRA2 Gene

mRNA expression in normal human tissues for GLRA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GLRA2 Gene

This gene is overexpressed in Brain - Hypothalamus (10.5), Brain - Cerebellar Hemisphere (8.0), Brain - Cerebellum (6.7), Brain - Amygdala (5.7), and Brain - Anterior cingulate cortex (BA24) (4.0).

Protein differential expression in normal tissues for GLRA2 Gene

This gene is overexpressed in Fetal Brain (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for GLRA2 Gene

SOURCE GeneReport for Unigene cluster for GLRA2 Gene Hs.2700

genes like me logo Genes that share expressions with GLRA2: view

Expression partners for GLRA2 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for GLRA2 Gene

Orthologs for GLRA2 Gene

This gene was present in the common ancestor of animals.

Orthologs for GLRA2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GLRA2 35
  • 92.99 (n)
  • 98.01 (a)
GLRA2 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GLRA2 35
  • 94.91 (n)
  • 99.78 (a)
GLRA2 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Glra2 35
  • 92.85 (n)
  • 98.67 (a)
Glra2 16
Glra2 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GLRA2 35
  • 99.85 (n)
  • 99.78 (a)
GLRA2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100910572 35
  • 93.22 (n)
  • 99.12 (a)
oppossum
(Monodelphis domestica)
Mammalia GLRA2 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GLRA2 36
  • 97 (a)
OneToOne
chicken
(Gallus gallus)
Aves GLRA2 35
  • 85.55 (n)
  • 96.02 (a)
GLRA2 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GLRA2 36
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia glra2 35
  • 80.74 (n)
  • 92.89 (a)
zebrafish
(Danio rerio)
Actinopterygii glra2 35
  • 71.16 (n)
  • 83.15 (a)
glra2 36
  • 76 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11340 37
  • 30 (a)
CG6927 37
  • 31 (a)
CG7589 37
  • 31 (a)
CG8916 37
  • 41 (a)
GluClalpha 37
  • 43 (a)
ort 37
  • 41 (a)
Rdl 37
  • 46 (a)
worm
(Caenorhabditis elegans)
Secernentea avr-14 37
  • 40 (a)
C39B10.2 37
  • 37 (a)
C53D6.3 37
  • 30 (a)
F09G2.5 37
  • 28 (a)
F11H8.2 37
  • 37 (a)
F55D10.5 37
  • 36 (a)
F58G6.4 37
  • 30 (a)
gbr-4 37
  • 34 (a)
gbr-5 37
  • 36 (a)
gbr-6 37
  • 31 (a)
glc-1 37
  • 39 (a)
glc-2 37
  • 37 (a)
glc-3 37
  • 45 (a)
glc-4 37
  • 32 (a)
K10D6.1 37
  • 30 (a)
T20B12.9 37
  • 29 (a)
T24D8.1 37
  • 38 (a)
T27E9.9 37
  • 29 (a)
W10G11.16 37
  • 30 (a)
Y39A3B.2 37
  • 36 (a)
Y71D11A.5 37
  • 30 (a)
Y73F8A.2 37
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 59 (a)
OneToMany
Species with no ortholog for GLRA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GLRA2 Gene

ENSEMBL:
Gene Tree for GLRA2 (if available)
TreeFam:
Gene Tree for GLRA2 (if available)

Paralogs for GLRA2 Gene

genes like me logo Genes that share paralogs with GLRA2: view

Variants for GLRA2 Gene

Sequence variations from dbSNP and Humsavar for GLRA2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs726292 -- 14,585,008(+) CTTGT(A/G)TCTCT intron-variant
rs726293 -- 14,585,054(+) GCCCT(A/G)ACAAC intron-variant
rs986927 -- 14,576,376(+) AAACA(C/T)AGAAA intron-variant
rs986928 -- 14,576,608(+) AAATG(A/T)AAATG intron-variant
rs989011 -- 14,572,524(+) GAATT(C/T)TATAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GLRA2 Gene

Variant ID Type Subtype PubMed ID
nsv526475 CNV Gain 19592680
nsv522625 CNV Gain 19592680
nsv518002 CNV Gain 19592680
nsv518062 CNV Gain 19592680
nsv6810 CNV Loss 18451855
dgv502n21 CNV Gain 19592680
nsv520933 CNV Gain 19592680
nsv507947 CNV Insertion 20534489
nsv6811 CNV Insertion 18451855
esv27338 CNV Loss 19812545
esv1737273 CNV Insertion 17803354
esv2739975 CNV Deletion 23290073
esv2739976 CNV Deletion 23290073
nsv9934 CNV Loss 18304495

Relevant External Links for GLRA2 Gene

HapMap Linkage Disequilibrium report
GLRA2
Locus Specific Mutation Databases (LSDB)
GLRA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLRA2 Gene

Disorders for GLRA2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for GLRA2 Gene in MalaCards »

(2) Diseases for GLRA2 Gene including...

(1) University of Copenhagen DISEASES for GLRA2 Gene

Relevant External Links for GLRA2

Genetic Association Database (GAD)
GLRA2
Human Genome Epidemiology (HuGE) Navigator
GLRA2
genes like me logo Genes that share disorders with GLRA2: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for GLRA2 Gene

Publications for GLRA2 Gene

  1. Structure of the human alpha 2 subunit gene of the glycine receptor: use of vectorette and Alu-exon PCR. (PMID: 8973915) Monani U.R. … Burghes A.H.M. (Genome Res. 1996) 3 4 23
  2. Multiple sites of ethanol action in alpha1 and alpha2 glycine receptors suggested by sensitivity to pressure antagonism. (PMID: 15147510) Davies D.L. … Alkana R.L. (J. Neurochem. 2004) 3 23
  3. Alpha subunit variants of the human glycine receptor: primary structures, functional expression and chromosomal localization of the corresponding genes. (PMID: 2155780) Grenningloh G. … Betz H. (EMBO J. 1990) 3 4
  4. Analysis of the genomic structure of the human glycine receptor alpha-2 subunit gene and exclusion of this gene as a candidate for Rett syndrome. (PMID: 9674912) Cummings C.J. … Zoghbi H.Y. (Am. J. Med. Genet. 1998) 3 4
  5. Differential agonist sensitivity of glycine receptor alpha2 subunit splice variants. (PMID: 15302677) Miller P.S. … Smart T.G. (Br. J. Pharmacol. 2004) 3 4

Products for GLRA2 Gene

  • Addgene plasmids for GLRA2

Sources for GLRA2 Gene

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