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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

GLRA2 Gene

protein-coding GIFtS: 66
GCID: GC0XP014457

glycine receptor, alpha 2

(Previous symbol: GLR)

Explore 8 diseases affiliated with
GLRA2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Glycine Receptor, Alpha 2¹ ²
GLR¹ ²
Glycine Receptor Alpha 2 Subunit²
Glycine Receptor Subunit Alpha-2²
Glycine Receptor, Alpha-2 Polypeptide²

External Ids:	HGNC: 4327¹	Entrez Gene: 2742²	Ensembl: ENSG00000101958⁷	OMIM: 305990⁵	UniProtKB: P23416³

Export aliases for GLRA2 gene to outside databases

Previous GC identifers: GC0XP013992 GC0XP013373 GC0XP013749 GC0XP013909 GC0XP014307 GC0XP012306

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GLRA2:

The glycine receptor consists of two subunits, alpha and beta, and acts as a pentamer. The protein encoded by this gene

is an alpha subunit and can bind strychnine. Several transcript variants encoding different isoforms have been found

for this gene.(provided by RefSeq, Jan 2010)

UniProtKB/Swiss-Prot: GLRA2_HUMAN, P23416

Function: The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases

the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing)

summary for GLRA2:

Glycine receptors (GlyR) are members of the cys-loop family of ligand-gated ion channels, responsible for

mediating the inhibitory effects of glycine. They are widely distributed throughout the CNS, particularly

within the hippocampus, spinal cord and brain stem. Glycine receptors exist as pentameric proteins,

homo-oligomers of the alpha isoforms (alpha1, alpha2, alpha3 or alpha4) or hetero-oligomers which also

contain the beta-subtype variant (beta1) which is essential for targeting the receptor to the synapse.

Glycine receptors contain an integral chloride channel, and have modulatory sites for anesthetics,

neurosteroids, cannabinoids and ethanol. Disruption in glycine receptor expression or ion channel function

can result in hyperekplexia, a rare neurological disorder.

Gene Wiki entry for GLRA2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000023.10 NC_018934.1 NT_167197.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the GLRA2 gene promoter:
TBP FOXF2 Brachyury Nkx2-5 E4BP4 Arnt SRY TFIID HOXA5 TGIF
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GLRA2 promoter sequence

Search SABiosciences Chromatin IP Primers for GLRA2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GLRA2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.2 Ensembl cytogenetic band: Xp22.2 HGNC cytogenetic band: Xp22.2

GLRA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GLRA2 gene location

GeneLoc information about chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XP014457: view genomic region (about GC identifiers)

Start:	14,547,420 bp from pter	End:	14,749,934 bp from pter
Size:	202,515 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: GLRA2_HUMAN, P23416 (See protein sequence)

Recommended Name: Glycine receptor subunit alpha-2 precursor

Size: 452 amino acids; 52002 Da

Subunit: Pentamer composed of alpha and beta subunits

Subcellular location: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane;

Multi-pass membrane protein

Miscellaneous: The alpha subunit binds strychnine

Secondary accessions: A8K0J6 B2R6I8 B7Z4F5 J3KQ59 Q53YX7 Q6ICQ0 Q99862

Alternative splicing: 3 isoforms: P23416-1 P23416-2 P23416-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for GLRA2: NX_P23416

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P23416

GLRA2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001112357.1 NP_001112358.1 NP_001165413.1 NP_002054.1

ENSEMBL proteins:

ENSP00000218075 ENSP00000347123 ENSP00000391606 ENSP00000387756

Reactome Protein details: P23416
Human Recombinant Protein Products for GLRA2:

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	Browse Proteins at Uscn

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	NAS	2155780
GO:0030054	cell junction	IEA	--
GO:0034707	chloride channel complex	IEA	--
GO:0045211	postsynaptic membrane	IEA	--

GLRA2 for ontologies About GeneDecksing

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	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

GLRA2 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR008129 Glycine_rcpt_A2

IPR008127 Glycine_rcpt_A

IPR018000 Neurotransmitter_ion_chnl_CS

IPR006028 GABAA_rcpt

IPR006201 Neur_channel

Graphical View of Domain Structure for InterPro Entry P23416

ProtoNet protein and cluster: P23416

3 Blocks protein families:

IPB006028 Gamma-aminobutyric acid A (GABAA) receptor signature

IPB006201 Neurotransmitter-gated ion-channel

IPB008129 Glycine receptor alpha 2 subunit signature

UniProtKB/Swiss-Prot: GLRA2_HUMAN, P23416

Similarity: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA2

sub-subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: GLRA2_HUMAN, P23416

Function: The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases

the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing)

Genatlas biochemistry entry for GLRA2:

glycine receptor,alpha 2 subunit

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	--	--
GO:0005230	extracellular ligand-gated ion channel activity	--	--
GO:0016594	glycine binding	IDA	2155780
GO:0016934	extracellular-glycine-gated chloride channel activity	IDA	2155780
GO:0022824	transmitter-gated ion channel activity	IEA	--

GLRA2 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for GLRA2:

Increased resistance to MDM2 i

6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Glra2):

behavior/neurological	growth/size	mortality/aging	nervous system	reproductive system
vision/eye

GLRA2 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for GLRA2: Glra2^tm1Clc Glra2^tm1Lex

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for GLRA2

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		SwitchGear 3'UTR luciferase reporter plasmid: GLRA2 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GLRA2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

PKA activation in glucagon signalling

Neurophysiological process_PGE2-induced pain processing

0.44

Neurophysiological process PGE2-induced pain processing

0.44

Ion channel transport

Ion channel transport

1.00

SLC-mediated transmembrane transport

Transmembrane transport of small molecules

0.50

GABA A receptor activation

Ligand-gated ion channel transport

0.48

Class A/1 (Rhodopsin-like receptors)

Neuroactive ligand-receptor interaction

0.38

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for GLRA2

Neurophysiological process PGE2-induced pain processing

1 GeneGo (Thomson Reuters) Pathway for GLRA2

Neurophysiological process PGE2-induced pain processing

3 Reactome Pathways for GLRA2

	Ligand-gated ion channel transport
	Transmembrane transport of small molecules
	Ion channel transport

1 Kegg Pathway (Kegg details for GLRA2):

Neuroactive ligand-receptor interaction

GLRA2 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for GLRA2

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

5/12 Interacting proteins for GLRA2 (P23416^{2, 3} ENSP00000218075⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 12)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BAG6	P46379²^,³	MINT-63602 I2D: score=4
PSD	A5PKW4³, ENSP00000020673⁴	STRING: ENSP00000020673 I2D: score=3
GPR108	Q9NPR9³	I2D: score=1
GLRA1	ENSP00000274576⁴	STRING: ENSP00000274576
GLRA3	ENSP00000274093⁴	STRING: ENSP00000274093

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006811	ion transport	IDA	2155780
GO:0007218	neuropeptide signaling pathway	IDA	2155780
GO:0007416	synapse assembly	IEA	--
GO:0034220	ion transmembrane transport	TAS	--
GO:0055085	transmembrane transport	TAS	--

GLRA2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

GLRA2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for GLRA2 available from Tocris Bioscience About this table

Compound	Action	CAS #
beta-Alanine	Endogenous glycine agonist, more selective than taurine (Cat. No. 0209)	[107-95-9]
Strychnine hydrochloride	Competitive glycine receptor antagonist	[1421-86-9]
L-Serine	Weak endogenous glycine receptor agonist	[56-45-1]
Hypotaurine	Non-selective endogenous glycine receptor agonist	[300-84-5]
Glycine	Endogenous potentiator, co-transmitter	[56-40-6]

3 HMDB Compounds for GLRA2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Chlorine	Cl2 (see all 13)	16887-00-6	--
Ethanol	1-Hydroxyethane (see all 57)	64-17-5	--
Glycine	2-Aminoacetate (see all 15)	56-40-6	--

4 DrugBank Compounds for GLRA2 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Ethanol	Absolute Alcohol (see all 34)	64-17-5	target	agonist	20713066 17139284 9452448 17016423
Glycine	2-Aminoacetic acid (see all 4)	56-40-6	target	--	17012403 16847326 17550639
Lindane	Benzene hexachloride (see all 11)	58-89-9	target	antagonist	20600211 12614680
Picrotoxin	--	124-87-8	target	antagonist	17714449 17405877

4 Novoseek chemical compound relationships for GLRA2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
strychnine	60.6	1	10065998 (1)
bicuculline	48.3	4	10729364 (3)
gaba	38	3	15046720 (1), 18288700 (1)
ethanol	26.2	3	9726286 (1), 15147510 (1), 8968539 (1)

Search CenterWatch for drugs/clinical trials and news about GLRA2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for GLRA2 gene (4 alternative transcripts):

NM_001118885.1 NM_001118886.1 NM_001171942.1 NM_002063.3

Unigene Cluster for GLRA2:

Glycine receptor, alpha 2

Hs.2700 [show with all ESTs]

Unigene Representative Sequence: NM_002063

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000218075(uc010neq.3 uc004cwe.4) ENST00000355020 ENST00000415367

ENST00000443437(uc011mio.2 uc010nep.3 uc011mip.2)

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Additional cDNA sequence:

AK289561.1 AK297268.1 AK297304.1 AK312591.1 AY437083.1 AY437084.1 BC032864.2 BC045547.1

CR450343.1 X52008.1

5 DOTS entries:

DT.106943 DT.121309199 DT.121309166 DT.91837909 DT.106944

14 AceView cDNA sequences:

AA457277 AY437083 AY437084 CR450343 AA458707 BI599001 X52008 NM_002063

AV729257 BI547861 BC045547 BC032864 AA463244 AA463245

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

GLRA2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCTGTACAA

About this image

GLRA2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Amacrine, Retina

Spinal Neural Tube Cells

Neural Ectoderm

Spinal Cord

Presumptive Spinal Cord

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See GLRA2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GLRA2

SOURCE GeneReport for Unigene cluster: Hs.2700

SABiosciences Custom PCR Arrays for GLRA2

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GLRA2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for GLRA2 gene from 5/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	GLRA2¹	glycine receptor, alpha 2	85.55(n) 96.02(a)		772019 XM_001234290.2 XP_001234291.1
lizard (Anolis carolinensis)	Reptilia	GLRA2⁶	--	95(a)	1 ↔ 1	3(120971910-121094057)
zebrafish (Danio rerio)	Actinopterygii	glra2¹	glycine receptor alpha 2	71.16(n) 83.15(a)		793646 NM_001167899.1 NP_001161371.1
fruit fly (Drosophila melanogaster)	Insecta	Rdl³	response to cyclodiene GABA-A receptor	46(a) (best of 7)		3 67A1 --
worm (Caenorhabditis elegans)	Secernentea	glc-3³	ligand-gated ionic channel subunit	45(a) (best of 22)		V(5449241-5453240) --

ENSEMBL Gene Tree for GLRA2 (if available)
TreeFam Gene Tree for GLRA2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for GLRA2 gene

GABRR1² GLRB² GLRA1² GABRB1² GABRD² GLRA4² GABRP² GABRB2²

GABRQ² GABRB3² GLRA3² GABRR2²

18/24 SIMAP similar genes for GLRA2 using alignment to 2 protein entries: GLRA2_HUMAN (see all proteins) (see all similar genes):

GLRA1 GLRA4 GLRA3 GABRA2 GABRP GABRQ

GABRA4 GABRA5 GLRB GABRA6 GABRB2 GABRR1

GABRR2 GABRG3 GABRB1 GABRD GABRR3 GABRB3

GLRA2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr X pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs192793590^1,2		--	14545466(+)	`GGGCGC/TGGTGG`	4	--	us2k¹		0	--	--	--	--
rs183313484^1,2		--	14545652(+)	`GAATCA/GCTTGA`	4	--	us2k¹		0	--	--	--	--
rs187803212^1,2		--	14545661(+)	`GAACCC/TGGGAG`	4	--	us2k¹		0	--	--	--	--
rs6630545^1,2	C,H	--	14545836(+)	`TATACC/GTAATT`	4	--	us2k¹		4		NS EA	418
rs193179417^1,2		--	14546031(+)	`AGGGAC/TGTCTC`	4	--	us2k¹		0	--	--	--	--
rs184221632^1,2		--	14546178(+)	`TTCCTA/GTATTT`	4	--	us2k¹		0	--	--	--	--
rs144955235^1,2		--	14546227(+)	`TATAGA/GCTCTT`	4	--	us2k¹		0	--	--	--	--
rs147953277^1,2		--	14546471(+)	`TGATCC/TAAAGT`	4	--	us2k¹		0	--	--	--	--
rs189459948^1,2		--	14547294(+)	`TCTGAA/GTCCTG`	4	--	us2k¹		0	--	--	--	--
rs192413422^1,2		--	14547522(+)	`CCTTCC/GAACAG`	4	--	ut5¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for GLRA2 (14547420 - 14749934 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for GLRA2
3 Indels: 83348 96487 73937
Locus Specific Mutation Databases (LSDB): GLRA2

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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GLRA2 for disorders           About GeneDecksing

OMIM gene information: 305990    OMIM disorders: --

8 diseases for GLRA2:    About MalaCards

hyperekplexia coffin-lowry syndrome dyscalculia rett syndrome

pharyngitis schizophrenia neuronitis alcoholism

1 disease from the University of Copenhagen DISEASES database for GLRA2:

Dyscalculia

Human Genome Epidemiology (HuGE) Navigator: GLRA2 (4 documents)

Export disorders for GLRA2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for GLRA2 gene, integrated from 9 sources (see all 42):
(articles sorted by number of sources associating them with GLRA2)

Utopia: connect your pdf to the dynamic
world of online information

Structure of the human alpha 2 subunit gene of the glycine receptor: use of vectorette and Alu-exon PCR. (PubMed id 8973915)^{1, 2, 9} Monani U.R. and Burghes A.H.M. (1996)
Differential agonist sensitivity of glycine receptor alpha2 subunit splice variants. (PubMed id 15302677)^{1, 2} Miller P.S.... Smart T.G. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Analysis of the genomic structure of the human glycine receptor alpha-2 subunit gene and exclusion of this gene as a candidate for Rett syndrome. (PubMed id 9674912)^{1, 2} Cummings C.J.... Zoghbi H.Y. (1998)
Alpha subunit variants of the human glycine receptor: primary structures, functional expression and chromosomal localization of the corresponding genes. (PubMed id 2155780)^{1, 2} Grenningloh G.... Betz H. (1990)
Multiple sites of ethanol action in alpha1 and alpha2 glycine receptors suggested by sensitivity to pressure antagonism. (PubMed id 15147510)^{1, 9} Davies D.L....Alkana R.L. (2004)
Differentiated human midbrain-derived neural progenito r cells express excitatory strychnine-sensitive glycine receptors containing a2b subunits. (PubMed id 22606311)¹ Wegner F....Schwarz J. (2012)
3D structure and allosteric modulation of the transme mbrane domain of pentameric ligand-gated ion channels. (PubMed id 20713066)⁷ Baenziger J.E. and Corringer P.J. (2011)
Lysophosphatidylcholine increases neutrophil bacteric idal activity by enhancement of azurophil granule-phagosome fusion via glycine. GlyR alpha 2/TRPM2/p38 MAPK signaling. (PubMed id 20237295)¹ Hong C.W....Song D.K. (2010)
Dual actions of lindane (I^-hexachlorocyclohexane) on calcium homeostasis and exocytosis in rat PC12 cells. (PubMed id 20600211)⁷ Heusinkveld H.J....Westerink R.H. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 2742	HGNC: 4327	AceView: GLRA2	Ensembl:ENSG00000101958	euGenes: HUgn2742
ECgene: GLRA2	Kegg: 2742	H-InvDB: GLRA2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for GLRA2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for GLRA2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for GLRA2 gene:
Search GeneIP for patents involving GLRA2

GeneCards and IP:
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