External Ids for GLP2R Gene
This gene encodes a G protein-coupled receptor that is closely related to the glucagon receptor and binds to glucagon-like peptide-2 (GLP2). Signalling through GLP2 stimulates intestinal growth and increases villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. [provided by RefSeq, Dec 2014]
GeneCards Summary for GLP2R Gene
GLP2R (Glucagon-Like Peptide 2 Receptor) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and glucagon receptor activity. An important paralog of this gene is VIPR2.
UniProtKB/Swiss-Prot for GLP2R Gene
This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase
Glucagon-like peptide 2 (GLP-2) receptors are members of the glucagon receptor family that also includes glucagon, GLP-1, secretin, GHRH and GIP receptors. GLP-2 receptors are found in the central nervous system and the gastrointestinal system, with the highest expression levels in the jejunum. The principle role of GLP-2 receptors appears to be the maintenance of the growth and absorptive function of the intestinal mucosal villus epithelium and they have also been implicated in nutrient absorption. The human GLP-2 receptor gene is localized on chromosome 17p13.3.