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GLP2R Gene

protein-coding   GIFtS: 64
GCID: GC17P009670

Glucagon-Like Peptide 2 Receptor

  Search for GLP2R
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Glucagon-Like Peptide 2 Receptor1 2
GLP-2-R2 3
GLP-2R2 3
GLP-2 Receptor2 3

External Ids:    HGNC: 43251   Entrez Gene: 93402   Ensembl: ENSG000000653257   OMIM: 6036595   UniProtKB: O958383   

Export aliases for GLP2R gene to outside databases

Previous GC identifers: GC17P010095 GC17P010844 GC17P009672 GC17P009929


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GLP2R Gene:
The GLP2 receptor (GLP2R) is a G protein-coupled receptor superfamily member closely related to the glucagon
receptor ans GLP1 receptor. Glucagon-like peptide-2 (GLP2) is a 33-amino acid proglucagon-derived peptide
produced by intestinal enteroendocrine cells. Like glucagon-like peptide-1 (GLP1) and glucagon itself, it is
derived from the proglucagon peptide encoded by the GCG gene. GLP2 stimulates intestinal growth and upregulates
villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased
enterocyte apoptosis. Moreover, GLP2 prevents intestinal hypoplasia resulting from total parenteral nutrition.
GLP2R, a G protein-coupled receptor superfamily member is expressed in the gut and closely related to the
glucagon receptor (GCGR) and the receptor for GLP1 (GLP1R). (provided by RefSeq, Jul 2008)

GeneCards Summary for GLP2R Gene:
GLP2R (glucagon-like peptide 2 receptor) is a protein-coding gene. GO annotations related to this gene include glucagon receptor activity and G-protein coupled receptor activity. An important paralog of this gene is GLP1R.

UniProtKB/Swiss-Prot: GLP2R_HUMAN, O95838
Function: This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins
which activate adenylyl cyclase

summary for GLP2R Gene:
Glucagon-like peptide 2 (GLP-2) receptors are members of the glucagon receptor family that also includes
glucagon, GLP-1, secretin, GHRH and GIP receptors. GLP-2 receptors are found in the central nervous system
and the gastrointestinal system, with the highest expression levels in the jejunum. The principle role of
GLP-2 receptors appears to be the maintenance of the growth and absorptive function of the intestinal
mucosal villus epithelium and they have also been implicated in nutrient absorption. The human GLP-2
receptor gene is localized on chromosome 17p13.3.

Gene Wiki entry for GLP2R (Glucagon-like peptide 2 receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010718.17  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the GLP2R gene promoter:
         Tal-1   SREBP-1c   Olf-1   Ik-3   E47   GATA-2   SREBP-1b   Nkx6-1   SREBP-1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGLP2R promoter sequence
   Search Chromatin IP Primers for GLP2R

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GLP2R


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.3   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.3

GLP2R Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GLP2R gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P009670:  view genomic region     (about GC identifiers)

Start:
9,725,523 bp from pter      End:
9,795,419 bp from pter
Size:
69,897 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GLP2R_HUMAN, O95838 (See protein sequence)
Recommended Name: Glucagon-like peptide 2 receptor  
Size: 553 amino acids; 63001 Da
Secondary accessions: Q4VAT3

Explore the universe of human proteins at neXtProt for GLP2R: NX_O95838

Explore proteomics data for GLP2R at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn97, Asn113, Asn148, Asn162

  • See GLP2R Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004237.1  
    ENSEMBL proteins: 
     ENSP00000458242   ENSP00000262441   ENSP00000404471   ENSP00000303605  
    Reactome Protein details: O95838

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GCGR: GPCR / Class B : Glucagon receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: GLP-2 receptor
    Glucagon receptor family

    4 InterPro protein domains:
     IPR001879 GPCR_2_extracellular_dom
     IPR000832 GPCR_2_secretin-like
     IPR017983 GPCR_2_secretin-like_CS
     IPR017981 GPCR_2-like

    Graphical View of Domain Structure for InterPro Entry O95838

    ProtoNet protein and cluster: O95838

    1 Blocks protein domain: IPB000832 G-protein coupled receptors family 2 (secretin-like)

    UniProtKB/Swiss-Prot: GLP2R_HUMAN, O95838
    Similarity: Belongs to the G-protein coupled receptor 2 family


    Find genes that share domains with GLP2R           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GLP2R_HUMAN, O95838
    Function: This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins
    which activate adenylyl cyclase

         Genatlas biochemistry entry for GLP2R:
    glucagon-like peptide 2 (intestinotrophic) receptor,expressed in the gut,G protein coupled receptor superfamily

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity ----
    GO:0004930G-protein coupled receptor activity TAS9990065
    GO:0004967glucagon receptor activity IEA--
         
    Find genes that share ontologies with GLP2R           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for GLP2R:
     Increased gamma-H2AX phosphory 

         9 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Glp2r):
     adipose tissue  behavior/neurological  digestive/alimentary  endocrine/exocrine gland  growth/size/body 
     homeostasis/metabolism  mortality/aging  no phenotypic analysis  tumorigenesis 

    Find genes that share phenotypes with GLP2R           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for GLP2R: Glp2rtm1Ddr Glp2rtm1.2Xfg

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GLP2R
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GLP2R_HUMAN, O95838: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with GLP2R           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GLP2R About    
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3ADP signalling through P2Y purinoceptor 12
    Glucagon-type ligand receptors0.61
    Class B/2 (Secretin family receptors)0.36
    4GPCRs, Class B Secretin-like
    GPCRs, Class B Secretin-like
    5G alpha (s) signalling events
    G alpha (s) signalling events


    Find genes that share SuperPaths with GLP2R           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for GLP2R
        GPCRs, Class B Secretin-like


    2 Reactome Pathways for GLP2R
        Glucagon-type ligand receptors
    G alpha (s) signalling events


    1 Kegg Pathway  (Kegg details for GLP2R):
        Neuroactive ligand-receptor interaction

        Pathway & Disease-focused RT2 Profiler PCR Array including GLP2R: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for GLP2R

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GLP2R (O958382, 3 ENSP000002624414) via UniProtKB, MINT, STRING, and/or I2D (see all 68)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM2P621582, 3MINT-51641 I2D: score=3 
    CALM3P621582, 3MINT-51641 I2D: score=3 
    CALM1P621582, 3, ENSP000003494674MINT-51641 I2D: score=3 STRING: ENSP00000349467
    GCGP012753, ENSP000003876624I2D: score=1 STRING: ENSP00000387662
    ADCY2ENSP000003429524STRING: ENSP00000342952
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007166cell surface receptor signaling pathway ----
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007188adenylate cyclase-modulating G-protein coupled receptor signaling pathway IEA--
    GO:0008284positive regulation of cell proliferation TAS9990065
    GO:0071377cellular response to glucagon stimulus ----

    Find genes that share ontologies with GLP2R           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for GLP2R available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GLP-2 (human)Endogenous hormone; displays intestinotrophic activity[223460-79-5]
    GLP-2 (rat)Endogenous hormone; displays intestinotrophic activity[195262-56-7]

    2 DrugBank Compounds for GLP2R    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Glucagon recombinant-- 9007-92-5target--15817468 9990065 17016423 12529935 11212269 17139284
    Teduglutide ALX-0600 (see all 3)197922-42-2targetagonist23729002

    2 IUPHAR Ligands for GLP2R (GLP-2 receptor)    About this table
    LigandTypeActionAffinityPubmed IDs
    glucagon-like peptide 2
    AgonistFull agonist8.511738243
    glucagon-like peptide 2-(3-33)
    AgonistPartial agonist7.411738243

    2 Novoseek inferred chemical compound relationships for GLP2R gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    proglucagon 86 1 19644131 (1)
    alanine 3.44 1 10913301 (1)



    Find genes that share compounds with GLP2R           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GLP2R gene: 
    NM_004246.1  

    Unigene Cluster for GLP2R:

    Glucagon-like peptide 2 receptor
    Hs.248202  [show with all ESTs]
    Unigene Representative Sequence: BC043390
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000574745 ENST00000262441(uc002gmd.1) ENST00000458005 ENST00000304773

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    Additional mRNA sequence: 

    AF105367.1 AK295765.1 AK307283.1 AK314269.1 BC019818.1 BC041176.1 BC043390.1 BC096261.1 
    BC096262.1 BC096263.1 BC096264.1 

    1 DOTS entry:

    DT.91700533 

    18 AceView cDNA sequences:

    BX401082 BQ925506 BQ949241 BQ421674 BX482084 BC019818 NM_004246 BE619138 
    BC043390 BQ051297 BX369691 BC041176 BU192367 BX482083 AF105367 AA551387 
    BG436859 BE963902 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GLP2R expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAATCTATG
    GLP2R Expression
    About this image

    GLP2R Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GLP2R Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.248202
        Pathway & Disease-focused RT2 Profiler PCR Array including GLP2R: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for GLP2R gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Glp2r1 , 5 glucagon-like peptide 2 receptor1, 5 84.26(n)1
    82.02(a)1
      11 (41.13 cM)5
    938961  NM_175681.31  NP_783612.21 
     676615025 
    chicken
    (Gallus gallus)
    Aves GLP2R1 glucagon-like peptide 2 receptor 64.43(n)
    62.2(a)
      427787  NM_001163248.1  NP_001156720.1 
    lizard
    (Anolis carolinensis)
    Reptilia GLP2R6
    glucagon-like peptide 2 receptor
    53(a)
    1 ↔ 1
    2(109354914-109399688)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia glp2r1 glucagon-like peptide 2 receptor 61.32(n)
    54.91(a)
      101731683  XM_004919563.1  XP_004919620.1 
    zebrafish
    (Danio rerio)
    Actinopterygii GLP2R6
    glucagon-like peptide 2 receptor
    46(a)
    1 ↔ 1
    12(333835-341979) ENSDARG00000078548


    ENSEMBL Gene Tree for GLP2R (if available)
    TreeFam Gene Tree for GLP2R (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GLP2R gene
    GLP1R2  GHRHR2  GCGR2  CALCR2  PTH1R2  CRHR22  VIPR12  CRHR12  
    PTH2R2  CALCRL2  SCTR2  ADCYAP1R12  VIPR22  GIPR2  
    13 SIMAP similar genes for GLP2R using alignment to 8 protein entries:     GLP2R_HUMAN (see all proteins):
    GHRHR    GLP1R    GCGR    SCTR    GIPR    VIPR1
    PTH1R    CRHR1    VIPR2    PTHR2    CRHR2    CALCR
    PTH2R

    Find genes that share paralogs with GLP2R           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GLP2R (see all 1660)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs711360021,2
    C--9726138(+) TTTGA-/GCC   
       TTTGA
    CTTTG
    1 -- int11Minor allele frequency- GCCTTTGA:0.00NA 2
    rs1915189691,2
    --9727420(+) CTTGAA/TGATGT 1 -- us2k10--------
    rs1828388331,2
    --9727445(+) GAATAC/TCCCCC 1 -- us2k10--------
    rs790610201,2
    --9727486(+) TAGACA/GGTGAT 1 -- us2k10--------
    rs1383049311,2
    --9727539(+) GTCTGA/GGCACC 1 -- us2k10--------
    rs1413130361,2
    --9727545(+) GCACCC/TGTGTC 1 -- us2k10--------
    rs782353971,2
    F--9727553(+) GTCCTG/CTGCTC 1 -- us2k11Minor allele frequency- C:0.01NA 120
    rs1450670111,2
    --9727593(+) AGGGAA/GGAGGC 1 -- us2k10--------
    rs1115571081,2
    C,F--9727642(+) GGTGGG/AGAAGT 1 -- us2k12Minor allele frequency- A:0.03NA 122
    rs1483421431,2
    C--9727649(+) AAGTCA/GTGTGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for GLP2R (9725523 - 9795419 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for GLP2R:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv1976CNV Loss18451855
    nsv833360CNV Loss17160897
    nsv833361CNV Gain17160897
    nsv833358CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603659    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for GLP2R:
    Short bowel syndrome

    Find genes that share disorders with GLP2R           About GenesLikeMe

    3 Novoseek inferred disease relationships for GLP2R gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bowel disease 67.7 1 16174875 (1)
    mucositis 47.8 2 18829546 (1)
    inflammation 0 1 20167840 (1)

    Genetic Association Database (GAD): GLP2R
    Human Genome Epidemiology (HuGE) Navigator: GLP2R (9 documents)

    Export disorders for GLP2R gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GLP2R gene, integrated from 10 sources (see all 55):
    (articles sorted by number of sources associating them with GLP2R)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prototypic G protein-coupled receptor for the intestinotrophic factor glucagon-like peptide 2. (PubMed id 9990065)1, 2, 3, 7, 9 Munroe D.G.... Crivici A. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    2. The glucagon-like peptide-2 receptor C terminus modulates beta-arrestin-2 association but is dispensable for ligand-induced desensitization, endocytosis, and G-protein-dependent effector activation. (PubMed id 15817468)1, 7, 9 Estall J.L....Drucker D.J. (J. Biol. Chem. 2005)
    3. Genetic analysis in a Dutch study sample identifies more ulcerative colitis susceptibility loci and shows their additive role in disease risk. (PubMed id 19861958)1, 4 Festen E.A....Weersma R.K. (Am. J. Gastroenterol. 2010)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    6. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    7. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    8. GLP-2 receptor localizes to enteric neurons and endocrine cells expressing vasoactive peptides and mediates increased blood flow. (PubMed id 16401478)1, 9 Guan X....Burrin D.G. (Gastroenterology 2006)
    9. Glucagon-like peptide-2 does not modify the growth or survival of murine or human intestinal tumor cells. (PubMed id 18829546)1, 9 Koehler J.A....Drucker D.J. (Cancer Res. 2008)
    10. Enteroendocrine localization of GLP-2 receptor expression in humans and rodents. (PubMed id 10982769)1, 9 Yusta B....Drucker D.J. (Gastroenterology 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9340 HGNC: 4325 AceView: GLP2R Ensembl:ENSG00000065325 euGenes: HUgn9340
    ECgene: GLP2R Kegg: 9340 H-InvDB: GLP2R

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GLP2R Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for GLP2R gene:
    Search GeneIP for patents involving GLP2R

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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