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Aliases for GLP2R Gene

Aliases for GLP2R Gene

  • Glucagon Like Peptide 2 Receptor 2 3
  • Glucagon-Like Peptide 2 Receptor 2 5
  • GLP-2 Receptor 4
  • GLP-2-R 4
  • GLP-2R 4

External Ids for GLP2R Gene

Previous GeneCards Identifiers for GLP2R Gene

  • GC17P010095
  • GC17P010844
  • GC17P009672
  • GC17P009929
  • GC17P009670

Summaries for GLP2R Gene

Entrez Gene Summary for GLP2R Gene

  • This gene encodes a G protein-coupled receptor that is closely related to the glucagon receptor and binds to glucagon-like peptide-2 (GLP2). Signalling through GLP2 stimulates intestinal growth and increases villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. [provided by RefSeq, Dec 2014]

GeneCards Summary for GLP2R Gene

GLP2R (Glucagon Like Peptide 2 Receptor) is a Protein Coding gene. Among its related pathways are Presynaptic function of Kainate receptors and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and glucagon receptor activity. An important paralog of this gene is MGC57346-CRHR1.

UniProtKB/Swiss-Prot for GLP2R Gene

  • This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Tocris Summary for GLP2R Gene

  • Glucagon-like peptide 2 (GLP-2) receptors are members of the glucagon receptor family that also includes glucagon, GLP-1, secretin, GHRH and GIP receptors. GLP-2 receptors are found in the CNS and the gastrointestinal system, with the highest expression levels in the jejunum.

Gene Wiki entry for GLP2R Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLP2R Gene

Genomics for GLP2R Gene

Regulatory Elements for GLP2R Gene

Enhancers for GLP2R Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GLP2R on UCSC Golden Path with GeneCards custom track

Genomic Location for GLP2R Gene

9,822,206 bp from pter
9,892,104 bp from pter
69,899 bases
Plus strand

Genomic View for GLP2R Gene

Genes around GLP2R on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GLP2R Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GLP2R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLP2R Gene

Proteins for GLP2R Gene

  • Protein details for GLP2R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Glucagon-like peptide 2 receptor
    Protein Accession:
    Secondary Accessions:
    • Q4VAT3

    Protein attributes for GLP2R Gene

    553 amino acids
    Molecular mass:
    63001 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GLP2R Gene

Proteomics data for GLP2R Gene at MOPED

Post-translational modifications for GLP2R Gene

  • Glycosylation at Asn 97, Asn 113, Asn 148, and Asn 162
  • Modification sites at PhosphoSitePlus

Other Protein References for GLP2R Gene

Antibody Products

No data available for DME Specific Peptides for GLP2R Gene

Domains & Families for GLP2R Gene

Gene Families for GLP2R Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 2 family.
  • Belongs to the G-protein coupled receptor 2 family.
genes like me logo Genes that share domains with GLP2R: view

Function for GLP2R Gene

Molecular function for GLP2R Gene

GENATLAS Biochemistry:
glucagon-like peptide 2 (intestinotrophic) receptor,expressed in the gut,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
genes like me logo Genes that share phenotypes with GLP2R: view

Animal Models for GLP2R Gene

MGI Knock Outs for GLP2R:

Animal Model Products

  • Taconic Biosciences Mouse Models for GLP2R

miRNA for GLP2R Gene

miRTarBase miRNAs that target GLP2R

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GLP2R Gene

Localization for GLP2R Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLP2R Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for GLP2R Gene COMPARTMENTS Subcellular localization image for GLP2R gene
Compartment Confidence
plasma membrane 5

No data available for Gene Ontology (GO) - Cellular Components for GLP2R Gene

Pathways & Interactions for GLP2R Gene

genes like me logo Genes that share pathways with GLP2R: view

Pathways by source for GLP2R Gene

Gene Ontology (GO) - Biological Process for GLP2R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with GLP2R: view

No data available for SIGNOR curated interactions for GLP2R Gene

Drugs & Compounds for GLP2R Gene

(7) Drugs for GLP2R Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
teduglutide Approved Pharma Target, agonist 0
Glucagon recombinant Approved Pharma Target 0
glucagon-like peptide 2 Pharma Full agonist, Agonist 0
glucagon-like peptide 2-(3-33) Pharma Partial agonist, Agonist 0
BIX 01294 Pharma G9a and GLP inhibitor 0

(3) Additional Compounds for GLP2R Gene - From: Tocris and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
GLP-2 (human)
GLP-2 (rat)

(2) Tocris Compounds for GLP2R Gene

Compound Action Cas Number
GLP-2 (human) Endogenous hormone; displays intestinotrophic activity 223460-79-5
GLP-2 (rat) Endogenous hormone; displays intestinotrophic activity 195262-56-7

(1) ApexBio Compounds for GLP2R Gene

Compound Action Cas Number
BIX 01294 G9a and GLP inhibitor 935693-62-2
genes like me logo Genes that share compounds with GLP2R: view

Drug Products

Transcripts for GLP2R Gene

mRNA/cDNA for GLP2R Gene

Unigene Clusters for GLP2R Gene

Glucagon-like peptide 2 receptor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GLP2R Gene

No ASD Table

Relevant External Links for GLP2R Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GLP2R Gene

mRNA expression in normal human tissues for GLP2R Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GLP2R Gene

This gene is overexpressed in Bladder (x6.6), Colon - Sigmoid (x6.6), Small Intestine - Terminal Ileum (x4.8), and Adipose - Visceral (Omentum) (x4.4).

Protein differential expression in normal tissues from HIPED for GLP2R Gene

This gene is overexpressed in Placenta (28.3), Tlymphocyte (15.3), Bone marrow mesenchymal stem cell (10.3), Adipocyte (7.9), and Heart (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GLP2R Gene

SOURCE GeneReport for Unigene cluster for GLP2R Gene Hs.248202

genes like me logo Genes that share expression patterns with GLP2R: view

Protein tissue co-expression partners for GLP2R Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for GLP2R Gene

Orthologs for GLP2R Gene

This gene was present in the common ancestor of chordates.

Orthologs for GLP2R Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GLP2R 35
  • 82.82 (n)
  • 76.49 (a)
GLP2R 36
  • 76 (a)
(Canis familiaris)
Mammalia GLP2R 35
  • 84.04 (n)
  • 79.78 (a)
GLP2R 36
  • 79 (a)
(Mus musculus)
Mammalia Glp2r 35
  • 84.26 (n)
  • 82.02 (a)
Glp2r 16
Glp2r 36
  • 81 (a)
(Pan troglodytes)
Mammalia GLP2R 35
  • 99.46 (n)
  • 99.64 (a)
GLP2R 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Glp2r 35
  • 82.73 (n)
  • 79.09 (a)
(Monodelphis domestica)
Mammalia GLP2R 36
  • 62 (a)
(Gallus gallus)
Aves GLP2R 35
  • 64.43 (n)
  • 62.2 (a)
GLP2R 36
  • 58 (a)
(Anolis carolinensis)
Reptilia GLP2R 36
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia glp2r 35
  • 61.32 (n)
  • 54.91 (a)
(Danio rerio)
Actinopterygii GLP2R 36
  • 46 (a)
Species with no ortholog for GLP2R:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GLP2R Gene

Gene Tree for GLP2R (if available)
Gene Tree for GLP2R (if available)

Paralogs for GLP2R Gene

genes like me logo Genes that share paralogs with GLP2R: view

Variants for GLP2R Gene

Sequence variations from dbSNP and Humsavar for GLP2R Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs8072568 - 9,826,128(+) CGTCC(A/T)CGAGC reference, missense
rs17681684 - 9,889,451(+) GGAAG(A/G)ACTTC reference, missense
rs16958918 - 9,889,611(+) TGCAC(A/G/T)CTGGC reference, missense
rs940668 -- 9,854,201(-) AATTG(C/T)GTTCA intron-variant
rs1607987 -- 9,858,349(+) aggtt(C/T)tgaca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GLP2R Gene

Variant ID Type Subtype PubMed ID
nsv833358 CNV Gain 17160897
nsv833360 CNV Loss 17160897
nsv1976 CNV Loss 18451855
nsv833361 CNV Gain 17160897

Variation tolerance for GLP2R Gene

Residual Variation Intolerance Score: 57.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.19; 69.74% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GLP2R Gene

Disorders for GLP2R Gene

Relevant External Links for GLP2R

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GLP2R Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GLP2R Gene

Publications for GLP2R Gene

  1. Prototypic G protein-coupled receptor for the intestinotrophic factor glucagon-like peptide 2. (PMID: 9990065) Munroe D.G. … Crivici A. (Proc. Natl. Acad. Sci. U.S.A. 1999) 2 3 4 23 25 67
  2. The glucagon-like peptide-2 receptor C terminus modulates beta-arrestin-2 association but is dispensable for ligand-induced desensitization, endocytosis, and G-protein-dependent effector activation. (PMID: 15817468) Estall J.L. … Drucker D.J. (J. Biol. Chem. 2005) 3 23 25
  3. Glucagon-like peptide-2 does not modify the growth or survival of murine or human intestinal tumor cells. (PMID: 18829546) Koehler J.A. … Drucker D.J. (Cancer Res. 2008) 3 23
  4. GLP-2 receptor localizes to enteric neurons and endocrine cells expressing vasoactive peptides and mediates increased blood flow. (PMID: 16401478) Guan X. … Burrin D.G. (Gastroenterology 2006) 3 23
  5. Naturally occurring glucagon-like peptide-2 (GLP-2) receptors in human intestinal cell lines. (PMID: 16448646) Sams A. … Thim L. (Eur. J. Pharmacol. 2006) 3 23

Products for GLP2R Gene

Sources for GLP2R Gene