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Aliases for GLP2R Gene

Aliases for GLP2R Gene

  • Glucagon-Like Peptide 2 Receptor 2 3
  • GLP-2 Receptor 4
  • GLP-2-R 4
  • GLP-2R 4

External Ids for GLP2R Gene

Summaries for GLP2R Gene

Entrez Gene Summary for GLP2R Gene

  • This gene encodes a G protein-coupled receptor that is closely related to the glucagon receptor and binds to glucagon-like peptide-2 (GLP2). Signalling through GLP2 stimulates intestinal growth and increases villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. [provided by RefSeq, Dec 2014]

GeneCards Summary for GLP2R Gene

GLP2R (Glucagon-Like Peptide 2 Receptor) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and glucagon receptor activity. An important paralog of this gene is VIPR2.

UniProtKB/Swiss-Prot for GLP2R Gene

  • This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase

Tocris Summary for GLP2R Gene

  • Glucagon-like peptide 2 (GLP-2) receptors are members of the glucagon receptor family that also includes glucagon, GLP-1, secretin, GHRH and GIP receptors. GLP-2 receptors are found in the central nervous system and the gastrointestinal system, with the highest expression levels in the jejunum. The principle role of GLP-2 receptors appears to be the maintenance of the growth and absorptive function of the intestinal mucosal villus epithelium and they have also been implicated in nutrient absorption. The human GLP-2 receptor gene is localized on chromosome 17p13.3.

Gene Wiki entry for GLP2R Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLP2R Gene

Genomics for GLP2R Gene

Genomic Location for GLP2R Gene

9,822,206 bp from pter
9,892,102 bp from pter
69,897 bases
Plus strand

Genomic View for GLP2R Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GLP2R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLP2R Gene

Regulatory Elements for GLP2R Gene

Proteins for GLP2R Gene

  • Protein details for GLP2R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Glucagon-like peptide 2 receptor
    Protein Accession:
    Secondary Accessions:
    • Q4VAT3

    Protein attributes for GLP2R Gene

    553 amino acids
    Molecular mass:
    63001 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GLP2R Gene

Proteomics data for GLP2R Gene at MOPED

Post-translational modifications for GLP2R Gene

  • Glycosylation at Asn97, Asn113, Asn148, and Asn162

Other Protein References for GLP2R Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for GLP2R Gene

Domains for GLP2R Gene

Gene Families for GLP2R Gene

  • GCGR :GPCR / Class B : Glucagon receptors


  • Belongs to the G-protein coupled receptor 2 family.:
    • O95838
genes like me logo Genes that share domains with GLP2R: view

Function for GLP2R Gene

Molecular function for GLP2R Gene

GENATLAS Biochemistry: glucagon-like peptide 2 (intestinotrophic) receptor,expressed in the gut,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function: This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase

Gene Ontology (GO) - Molecular Function for GLP2R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity --
GO:0004930 G-protein coupled receptor activity TAS 9990065
GO:0004967 glucagon receptor activity IEA --
genes like me logo Genes that share ontologies with GLP2R: view
genes like me logo Genes that share phenotypes with GLP2R: view

Animal Models for GLP2R Gene

MGI Knock Outs for GLP2R:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for GLP2R Gene

Localization for GLP2R Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLP2R Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for GLP2R Gene COMPARTMENTS Subcellular localization image for GLP2R gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GLP2R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GLP2R: view

Pathways for GLP2R Gene

genes like me logo Genes that share pathways with GLP2R: view

Pathways by source for GLP2R Gene

Gene Ontology (GO) - Biological Process for GLP2R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway --
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IEA --
GO:0008284 positive regulation of cell proliferation TAS 9990065
GO:0071377 cellular response to glucagon stimulus IEA --
genes like me logo Genes that share ontologies with GLP2R: view

Compounds for GLP2R Gene

(2) Tocris Compounds for GLP2R Gene

Compound Action Cas Number
GLP-2 (human) Endogenous hormone; displays intestinotrophic activity [223460-79-5]
GLP-2 (rat) Endogenous hormone; displays intestinotrophic activity [195262-56-7]

(2) Drugbank Compounds for GLP2R Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Glucagon recombinant
9007-92-5 target
  • ALX-0600
197922-42-2 target agonist

(2) IUPHAR Ligand for GLP2R Gene

Ligand Type Action Affinity Pubmed IDs
glucagon-like peptide 2 Agonist Full agonist 8.5
glucagon-like peptide 2-(3-33) Agonist Partial agonist 7.4

(2) Novoseek inferred chemical compound relationships for GLP2R Gene

Compound -log(P) Hits PubMed IDs
proglucagon 86 1
alanine 3.44 1
genes like me logo Genes that share compounds with GLP2R: view

Transcripts for GLP2R Gene

mRNA/cDNA for GLP2R Gene

Unigene Clusters for GLP2R Gene

Glucagon-like peptide 2 receptor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GLP2R Gene

No ASD Table

Relevant External Links for GLP2R Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GLP2R Gene

mRNA expression in normal human tissues for GLP2R Gene

mRNA differential expression in normal tissues according to GTEx for GLP2R Gene

This gene is overexpressed in Bladder (6.6), Colon - Sigmoid (6.6), Small Intestine - Terminal Ileum (4.8), and Adipose - Visceral (Omentum) (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for GLP2R Gene

SOURCE GeneReport for Unigene cluster for GLP2R Gene Hs.248202

genes like me logo Genes that share expressions with GLP2R: view

Orthologs for GLP2R Gene

This gene was present in the common ancestor of chordates.

Orthologs for GLP2R Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GLP2R 36
  • 99.46 (n)
  • 99.64 (a)
GLP2R 37
  • 100 (a)
(Bos Taurus)
Mammalia GLP2R 36
  • 82.82 (n)
  • 76.49 (a)
GLP2R 37
  • 76 (a)
(Canis familiaris)
Mammalia GLP2R 36
  • 84.04 (n)
  • 79.78 (a)
GLP2R 37
  • 79 (a)
(Mus musculus)
Mammalia Glp2r 36
  • 84.26 (n)
  • 82.02 (a)
Glp2r 16
Glp2r 37
  • 81 (a)
(Monodelphis domestica)
Mammalia GLP2R 37
  • 62 (a)
(Rattus norvegicus)
Mammalia Glp2r 36
  • 82.73 (n)
  • 79.09 (a)
(Gallus gallus)
Aves GLP2R 36
  • 64.43 (n)
  • 62.2 (a)
GLP2R 37
  • 58 (a)
(Anolis carolinensis)
Reptilia GLP2R 37
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia glp2r 36
  • 61.32 (n)
  • 54.91 (a)
(Danio rerio)
Actinopterygii GLP2R 37
  • 46 (a)
Species with no ortholog for GLP2R:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GLP2R Gene

Gene Tree for GLP2R (if available)
Gene Tree for GLP2R (if available)

Paralogs for GLP2R Gene

genes like me logo Genes that share paralogs with GLP2R: view

Variants for GLP2R Gene

Sequence variations from dbSNP and Humsavar for GLP2R Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs756222 -- 9,865,549(+) TGCCC(A/G)ATGCT intron-variant
rs756223 -- 9,865,882(+) TTCCC(A/C/T)TTGGT intron-variant
rs756224 -- 9,865,624(+) ACATA(A/G/T)GCCTC intron-variant
rs905022 -- 9,884,864(+) AGGTA(A/G)TCCTA intron-variant
rs940668 -- 9,854,201(-) AATTG(C/T)GTTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GLP2R Gene

Variant ID Type Subtype PubMed ID
nsv833358 CNV Gain 17160897
nsv833360 CNV Loss 17160897
nsv1976 CNV Loss 18451855
nsv833361 CNV Gain 17160897

Relevant External Links for GLP2R Gene

HapMap Linkage Disequilibrium report

Disorders for GLP2R Gene

(1) University of Copenhagen DISEASES for GLP2R Gene

(3) Novoseek inferred disease relationships for GLP2R Gene

Disease -log(P) Hits PubMed IDs
bowel disease 67.7 1
mucositis 47.8 1
inflammation 0 1

Relevant External Links for GLP2R

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with GLP2R: view

No data available for UniProtKB/Swiss-Prot for GLP2R Gene

Publications for GLP2R Gene

  1. Prototypic G protein-coupled receptor for the intestinotrophic factor glucagon-like peptide 2. (PMID: 9990065) Munroe D.G. … Crivici A. (Proc. Natl. Acad. Sci. U.S.A. 1999) 2 3 4 23 25
  2. The glucagon-like peptide-2 receptor C terminus modulates beta-arrestin-2 association but is dispensable for ligand-induced desensitization, endocytosis, and G-protein-dependent effector activation. (PMID: 15817468) Estall J.L. … Drucker D.J. (J. Biol. Chem. 2005) 3 23 25
  3. The truncated metabolite GLP-2 (3-33) interacts with the GLP-2 receptor as a partial agonist. (PMID: 11738243) Thulesen J. … Poulsen S.S. (Regul. Pept. 2002) 3 23
  4. Glucagon-like peptide 2: a nutrient-responsive gut growth factor. (PMID: 11238747) Burrin D.G. … Sangild P. (J. Nutr. 2001) 3 23
  5. The HeLa cell glucagon-like peptide-2 receptor is coupled to regulation of apoptosis and ERK1/2 activation through divergent signaling pathways. (PMID: 15471943) Koehler J.A. … Drucker D.J. (Mol. Endocrinol. 2005) 3 23

Products for GLP2R Gene

Sources for GLP2R Gene

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