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Aliases for GLP1R Gene

Aliases for GLP1R Gene

  • Glucagon Like Peptide 1 Receptor 2 3 5
  • Glucagon-Like Peptide 1 Receptor 2 3
  • GLP-1 Receptor 3 4
  • GLP-1-R 3 4
  • GLP-1R 3 4
  • Seven Transmembrane Helix Receptor 3
  • GLP1 Receptor 3
  • GLP-1 3

External Ids for GLP1R Gene

Previous GeneCards Identifiers for GLP1R Gene

  • GC06P039018
  • GC06P039063
  • GC06P039124
  • GC06P038734

Summaries for GLP1R Gene

Entrez Gene Summary for GLP1R Gene

  • This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]

GeneCards Summary for GLP1R Gene

GLP1R (Glucagon Like Peptide 1 Receptor) is a Protein Coding gene. Diseases associated with GLP1R include Insulinoma and Pneumatosis Cystoides Intestinalis. Among its related pathways are Integration of energy metabolism and Presynaptic function of Kainate receptors. GO annotations related to this gene include G-protein coupled receptor activity and glucagon receptor activity. An important paralog of this gene is GCGR.

UniProtKB/Swiss-Prot for GLP1R Gene

  • This is a receptor for glucagon-like peptide 1. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Tocris Summary for GLP1R Gene

  • Glucagon-like peptide 1 (GLP-1) receptors are members of the glucagon receptor family that also includes glucagon, GLP-2, secretin, GHRH and GIP receptors. GLP-1 receptors are found both centrally and peripherally. GLP-1 receptors mediate the effects of the incretin axis.

Gene Wiki entry for GLP1R Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLP1R Gene

Genomics for GLP1R Gene

Regulatory Elements for GLP1R Gene

Enhancers for GLP1R Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G039114 1.4 ENCODE dbSUPER 10 +66.3 66294 2.1 HDGF PKNOX1 MLX CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 ZNF2 KCNK17 GLP1R SAYSD1 PIR35108 GC06M039505
GH06G039082 0.6 dbSUPER 22.9 +34.5 34506 1.9 CTCF RFX1 ZFHX2 ZNF776 ZKSCAN8 GLIS1 KLF9 EGR2 EZH2 GLP1R SAYSD1 DAAM2 LOC105375046 PIR34726 GC06M039484
GH06G039084 0.6 dbSUPER 22.3 +36.1 36111 1.2 ZNF776 GLIS1 ZKSCAN8 TEAD4 MNT ZIC2 GLP1R SAYSD1 GLO1 LOC105375046 PIR34726 GC06M039484
GH06G039101 1.2 Ensembl ENCODE dbSUPER 10.9 +53.3 53343 1.1 CTCF PKNOX1 ATF1 RB1 ZFP64 HLF REST RAD21 JUND KLF16 SAYSD1 GLP1R KCNK17 KCNK5 GC06M039484 PIR34726 LOC105375046
GH06G039093 0.9 FANTOM5 dbSUPER 12.5 +44.6 44633 0.0 NFIA FEZF1 ZBTB8A ZNF843 RAD21 FOXA1 JUND ATF3 HNF4A NR2F6 GLP1R SAYSD1 LOC105375046 PIR34726 GC06M039484
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GLP1R on UCSC Golden Path with GeneCards custom track

Genomic Location for GLP1R Gene

39,048,781 bp from pter
39,091,303 bp from pter
42,523 bases
Plus strand

Genomic View for GLP1R Gene

Genes around GLP1R on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GLP1R Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GLP1R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLP1R Gene

Proteins for GLP1R Gene

  • Protein details for GLP1R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Glucagon-like peptide 1 receptor
    Protein Accession:
    Secondary Accessions:
    • Q2M229
    • Q99669

    Protein attributes for GLP1R Gene

    463 amino acids
    Molecular mass:
    53026 Da
    Quaternary structure:
    • May form homodimers and heterodimers with GIPR.

    Three dimensional structures from OCA and Proteopedia for GLP1R Gene

neXtProt entry for GLP1R Gene

Post-translational modifications for GLP1R Gene

  • N-glycosylation enhances cell surface expression and lengthens receptor half-life by preventing degradation in the ER.
  • Glycosylation at isoforms=63, Asn82, and isoforms=115
  • Modification sites at PhosphoSitePlus

Other Protein References for GLP1R Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Protein Products

  • R&D Systems Peptides for GLP1R (GLP-1R)

No data available for DME Specific Peptides for GLP1R Gene

Domains & Families for GLP1R Gene

Gene Families for GLP1R Gene

Suggested Antigen Peptide Sequences for GLP1R Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 2 family.
  • Belongs to the G-protein coupled receptor 2 family.
genes like me logo Genes that share domains with GLP1R: view

Function for GLP1R Gene

Molecular function for GLP1R Gene

GENATLAS Biochemistry:
glucagon-like peptide 1,receptor,G protein coupled receptor superfamily,mediating the insulinotropic effect of the incretin hormone GLP1,regulated by SP1 and SP3
UniProtKB/Swiss-Prot Function:
This is a receptor for glucagon-like peptide 1. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Gene Ontology (GO) - Molecular Function for GLP1R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity TAS 8405712
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004967 glucagon receptor activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0008528 G-protein coupled peptide receptor activity IEA --
genes like me logo Genes that share ontologies with GLP1R: view
genes like me logo Genes that share phenotypes with GLP1R: view

Animal Models for GLP1R Gene

MGI Knock Outs for GLP1R:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GLP1R

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GLP1R Gene

Localization for GLP1R Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLP1R Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GLP1R gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 2
cytosol 2
mitochondrion 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for GLP1R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,TAS --
genes like me logo Genes that share ontologies with GLP1R: view

Pathways & Interactions for GLP1R Gene

genes like me logo Genes that share pathways with GLP1R: view

SIGNOR curated interactions for GLP1R Gene

Is activated by:

Gene Ontology (GO) - Biological Process for GLP1R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006950 response to stress IEA --
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007190 activation of adenylate cyclase activity TAS 8405712
genes like me logo Genes that share ontologies with GLP1R: view

Drugs & Compounds for GLP1R Gene

(62) Drugs for GLP1R Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Liraglutide Approved Pharma Full agonist, Agonist, agonist, Target 329
Exenatide Approved, Investigational Pharma binder, Target, agonist 296
Albiglutide Approved Pharma activator, Target, agonist 0
Lixisenatide Approved Pharma Target, agonist 0
Sitagliptin Approved, Investigational Pharma 0

(13) Additional Compounds for GLP1R Gene - From: IUPHAR and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Full agonist, Agonist
glucagon-like peptide-1-(7-37)
Full agonist, Agonist

(5) Tocris Compounds for GLP1R Gene

Compound Action Cas Number
Exendin-3 (9-39) amide Potent GLP-1 receptor antagonist 133514-43-9
Exendin-4 Potent GLP-1 receptor agonist 141758-74-9
GLP-1 (9-36) amide Metabolite of GLP-1-(7-36) (Cat. No. 2082) 161748-29-4
Glucagon-like peptide 1 (1-37) (human, rat) Endogenous pancreatic peptide 87805-34-3
Glucagon-like peptide 1 (7-36) amide (human, rat) Potent insulinotropic peptide 107444-51-9

(12) ApexBio Compounds for GLP1R Gene

Compound Action Cas Number
BETP 1371569-69-5
BIX 01294 G9a and GLP inhibitor 935693-62-2
des-His1-[Glu9]-Glucagon (1-29) amide 110084-95-2
Exendin-3 (9-39) amide 133514-43-9
Exendin-4 GLP-1 activator 141758-74-9
GLP-1 (9-36) amide 161748-29-4
GLP-2 (human) 223460-79-5
Glucagon-like peptide 1 (1-37) (human, rat) 87805-34-3
Glucagon-like peptide 1 (7-36) amide (human, rat) 107444-51-9
L-168,049 191034-25-0
Methylprednisolone Sodium Succinate 2375-03-3
Oxyntomodulin 62340-29-8
genes like me logo Genes that share compounds with GLP1R: view

Drug Products

Transcripts for GLP1R Gene

mRNA/cDNA for GLP1R Gene

(3) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GLP1R Gene

Glucagon-like peptide 1 receptor:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GLP1R

Alternative Splicing Database (ASD) splice patterns (SP) for GLP1R Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b · 14c ^ 15
SP1: - -
SP3: -
SP4: - - - -

Relevant External Links for GLP1R Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GLP1R Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GLP1R Gene

mRNA differential expression in normal tissues according to GTEx for GLP1R Gene

This gene is overexpressed in Pancreas (x18.8), Heart - Left Ventricle (x5.8), and Heart - Atrial Appendage (x5.7).

Protein differential expression in normal tissues from HIPED for GLP1R Gene

This gene is overexpressed in Platelet (32.1) and Fetal testis (31.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GLP1R Gene

Protein tissue co-expression partners for GLP1R Gene

NURSA nuclear receptor signaling pathways regulating expression of GLP1R Gene:


SOURCE GeneReport for Unigene cluster for GLP1R Gene:


Evidence on tissue expression from TISSUES for GLP1R Gene

  • Pancreas(4.6)
  • Nervous system(2.1)
  • Blood(2)
genes like me logo Genes that share expression patterns with GLP1R: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GLP1R Gene

Orthologs for GLP1R Gene

This gene was present in the common ancestor of chordates.

Orthologs for GLP1R Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GLP1R 34 35
  • 98.7 (n)
(Canis familiaris)
Mammalia GLP1R 34 35
  • 89.95 (n)
(Bos Taurus)
Mammalia GLP1R 34 35
  • 88.86 (n)
(Mus musculus)
Mammalia Glp1r 34 16 35
  • 87.19 (n)
(Rattus norvegicus)
Mammalia Glp1r 34
  • 87.04 (n)
(Monodelphis domestica)
Mammalia GLP1R 35
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia GLP1R 35
  • 73 (a)
(Gallus gallus)
Aves GLP-1R 35
  • 76 (a)
GLP1R 34
  • 74.51 (n)
(Anolis carolinensis)
Reptilia GLP1R 35
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia glp1r 34
  • 73.2 (n)
Species where no ortholog for GLP1R was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GLP1R Gene

Gene Tree for GLP1R (if available)
Gene Tree for GLP1R (if available)

Paralogs for GLP1R Gene

(12) SIMAP similar genes for GLP1R Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GLP1R: view

Variants for GLP1R Gene

Sequence variations from dbSNP and Humsavar for GLP1R Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000144199 -- 39,088,253(+) GATAC(C/T)GAACT nc-transcript-variant, utr-variant-3-prime
rs1000181238 -- 39,072,557(+) ATCCT(C/T)ATGCA intron-variant
rs1000184256 -- 39,049,340(+) TCTCC(C/T)GCAGT intron-variant
rs1000260493 -- 39,087,506(+) TGGCT(A/G)CAAAA nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs1000262617 -- 39,050,521(+) CAAAA(C/G)CTGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GLP1R Gene

Variant ID Type Subtype PubMed ID
esv3608753 CNV loss 21293372
nsv1015689 CNV gain 25217958
nsv1027064 CNV gain 25217958
nsv1031922 CNV gain 25217958
nsv462919 CNV loss 19166990
nsv470815 CNV loss 18288195
nsv519907 CNV loss 19592680
nsv528286 CNV gain 19592680
nsv602963 CNV loss 21841781

Variation tolerance for GLP1R Gene

Residual Variation Intolerance Score: 72.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.08; 87.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GLP1R Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLP1R Gene

Disorders for GLP1R Gene

MalaCards: The human disease database

(12) MalaCards diseases for GLP1R Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • islet cell tumor
pneumatosis cystoides intestinalis
fasting hypoglycemia
endocrine pancreas disease
  • disorder of endocrine pancreas
- elite association - COSMIC cancer census association via MalaCards
Search GLP1R in MalaCards View complete list of genes associated with diseases

Relevant External Links for GLP1R

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GLP1R: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GLP1R Gene

Publications for GLP1R Gene

  1. Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain. (PMID: 18287102) Runge S. … Rudolph R. (J. Biol. Chem. 2008) 3 4 22 64
  2. Five missense mutations in glucagon-like peptide 1 receptor gene in Japanese population. (PMID: 15364163) Tokuyama Y. … Kanatsuka A. (Diabetes Res. Clin. Pract. 2004) 3 22 46 64
  3. Signal transduction of the GLP-1-receptor cloned from a human insulinoma. (PMID: 7517895) van Eyll B. … Goeke B. (FEBS Lett. 1994) 3 4 22 64
  4. Cloning and functional expression of a human glucagon-like peptide-1 receptor. (PMID: 8216285) Graziano M.P. … Strader C.D. (Biochem. Biophys. Res. Commun. 1993) 3 4 22 64
  5. Cloning and functional expression of the human glucagon-like peptide- 1 (GLP-1) receptor. (PMID: 8404634) Dillon J.S. … Boyd A.E. (Endocrinology 1993) 3 4 22 64

Products for GLP1R Gene

  • Addgene plasmids for GLP1R

Sources for GLP1R Gene

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