Aliases for GLP1R Gene
External Ids for GLP1R Gene
Previous GeneCards Identifiers for GLP1R Gene
This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]
GeneCards Summary for GLP1R Gene
GLP1R (Glucagon Like Peptide 1 Receptor) is a Protein Coding gene. Diseases associated with GLP1R include insulinoma and fasting hypoglycemia. Among its related pathways are Signaling by GPCR and Metabolism. GO annotations related to this gene include G-protein coupled receptor activity and glucagon receptor activity. An important paralog of this gene is MGC57346-CRHR1.
UniProtKB/Swiss-Prot for GLP1R Gene
This is a receptor for glucagon-like peptide 1. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
Glucagon-like peptide 1 (GLP-1) receptors are members of the glucagon receptor family that also includes glucagon, GLP-2, secretin, GHRH and GIP receptors. GLP-1 receptors are found both centrally and peripherally. GLP-1 receptors mediate the effects of the incretin axis.