Aliases for GLP1R Gene
External Ids for GLP1R Gene
Previous GeneCards Identifiers for GLP1R Gene
GeneCards Summary for GLP1R Gene
GLP1R (Glucagon-Like Peptide 1 Receptor) is a Protein Coding gene. Diseases associated with GLP1R include fasting hypoglycemia and obesity. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include transmembrane signaling receptor activity and glucagon receptor activity. An important paralog of this gene is VIPR2.
UniProtKB/Swiss-Prot for GLP1R Gene
This is a receptor for glucagon-like peptide 1. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase
Glucagon-like peptide 1 (GLP-1) receptors are members of the glucagon receptor family that also includes glucagon, GLP-2, secretin, GHRH and GIP receptors. GLP-1 receptors are found both centrally (hypothalamus and brainstem) and peripherally (pancreatic islet cells, stomach and heart). GLP-1 receptors mediate the effects of the incretin axis; the functional connection between the intestine and the islets of Langerhans in the pancreas. Activation stimulates insulin release from the islet beta-cells in a glucose-dependent manner and suppresses glucagon secretion from islet alpha-cells. In addition, GLP-1 receptors delay gastric emptying and regulate appetite. The human GLP-1 receptor gene is localized on chromosome 6p21.