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Aliases for GLP1R Gene

Aliases for GLP1R Gene

  • Glucagon-Like Peptide 1 Receptor 2 3
  • GLP-1 Receptor 3 4
  • GLP-1-R 3 4
  • GLP-1R 3 4

External Ids for GLP1R Gene

Summaries for GLP1R Gene

GeneCards Summary for GLP1R Gene

GLP1R (Glucagon-Like Peptide 1 Receptor) is a Protein Coding gene. Diseases associated with GLP1R include fasting hypoglycemia and obesity. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include transmembrane signaling receptor activity and glucagon receptor activity. An important paralog of this gene is VIPR2.

UniProtKB/Swiss-Prot for GLP1R Gene

  • This is a receptor for glucagon-like peptide 1. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase

Tocris Summary for GLP1R Gene

  • Glucagon-like peptide 1 (GLP-1) receptors are members of the glucagon receptor family that also includes glucagon, GLP-2, secretin, GHRH and GIP receptors. GLP-1 receptors are found both centrally (hypothalamus and brainstem) and peripherally (pancreatic islet cells, stomach and heart). GLP-1 receptors mediate the effects of the incretin axis; the functional connection between the intestine and the islets of Langerhans in the pancreas. Activation stimulates insulin release from the islet beta-cells in a glucose-dependent manner and suppresses glucagon secretion from islet alpha-cells. In addition, GLP-1 receptors delay gastric emptying and regulate appetite. The human GLP-1 receptor gene is localized on chromosome 6p21.

Gene Wiki entry for GLP1R Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLP1R Gene

Genomics for GLP1R Gene

Genomic Location for GLP1R Gene

Start:
39,048,781 bp from pter
End:
39,088,881 bp from pter
Size:
40,101 bases
Orientation:
Plus strand

Genomic View for GLP1R Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GLP1R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLP1R Gene

Regulatory Elements for GLP1R Gene

Proteins for GLP1R Gene

  • Protein details for GLP1R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43220-GLP1R_HUMAN
    Recommended name:
    Glucagon-like peptide 1 receptor
    Protein Accession:
    P43220
    Secondary Accessions:
    • Q2M229
    • Q99669

    Protein attributes for GLP1R Gene

    Size:
    463 amino acids
    Molecular mass:
    53026 Da
    Quaternary structure:
    • May form homodimers and heterodimers with GIPR.

    Three dimensional structures from OCA and Proteopedia for GLP1R Gene

neXtProt entry for GLP1R Gene

Proteomics data for GLP1R Gene at MOPED

Post-translational modifications for GLP1R Gene

  • N-glycosylation enhances cell surface expression and lengthens receptor half-life by preventing degradation in the ER.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn63, Asn82, and Asn115

Other Protein References for GLP1R Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for GLP1R Gene

Domains for GLP1R Gene

Gene Families for GLP1R Gene

HGNC:
  • GCGR :GPCR / Class B : Glucagon receptors
IUPHAR :

UniProtKB/Swiss-Prot:

GLP1R_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 2 family.:
    • P43220
genes like me logo Genes that share domains with GLP1R: view

Function for GLP1R Gene

Molecular function for GLP1R Gene

GENATLAS Biochemistry: glucagon-like peptide 1,receptor,G protein coupled receptor superfamily,mediating the insulinotropic effect of the incretin hormone GLP1,regulated by SP1 and SP3
UniProtKB/Swiss-Prot Function: This is a receptor for glucagon-like peptide 1. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase

Gene Ontology (GO) - Molecular Function for GLP1R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity TAS 8405712
GO:0004930 G-protein coupled receptor activity --
GO:0004967 glucagon receptor activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with GLP1R: view
genes like me logo Genes that share phenotypes with GLP1R: view

Animal Models for GLP1R Gene

MGI Knock Outs for GLP1R:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for GLP1R Gene

Localization for GLP1R Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLP1R Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GLP1R Gene COMPARTMENTS Subcellular localization image for GLP1R gene
Compartment Confidence
plasma membrane 5
nucleus 2
endoplasmic reticulum 1
extracellular 1

Gene Ontology (GO) - Cellular Components for GLP1R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GLP1R: view

Pathways for GLP1R Gene

genes like me logo Genes that share pathways with GLP1R: view

Pathways by source for GLP1R Gene

Gene Ontology (GO) - Biological Process for GLP1R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006112 energy reserve metabolic process TAS --
GO:0006950 response to stress IEA --
GO:0007166 cell surface receptor signaling pathway --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007190 activation of adenylate cyclase activity TAS 8405712
genes like me logo Genes that share ontologies with GLP1R: view

Compounds for GLP1R Gene

(5) Tocris Compounds for GLP1R Gene

Compound Action Cas Number
Exendin-3 (9-39) amide Potent GLP-1 receptor antagonist [133514-43-9]
Exendin-4 Potent GLP-1 receptor agonist [141758-74-9]
GLP-1 (9-36) amide Metabolite of GLP-1-(7-36) (Cat. No. 2082) [161748-29-4]
Glucagon-like peptide 1 (1-37) (human, rat) Endogenous pancreatic peptide [87805-34-3]
Glucagon-like peptide 1 (7-36) amide (human, rat) Potent insulinotropic peptide [107444-51-9]

(3) Drugbank Compounds for GLP1R Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Exenatide
  • AC2993
141758-74-9 target agonist
Glucagon recombinant
9007-92-5 target
Liraglutide
  • Arg34Lys26-(N-ε-(γ-Glu(N-α-hexadecanoyl)))-GLP-1[7-37]
204656-20-2 target agonist

(12) IUPHAR Ligand for GLP1R Gene

Ligand Type Action Affinity Pubmed IDs
liraglutide Agonist Full agonist 10.2
[125I]GLP-1-(7-36)-amide Agonist Full agonist 9.3
glucagon-like peptide 1-(7-36) amide Agonist Full agonist 9.2
exendin-4 Agonist Full agonist 9
glucagon Agonist Full agonist 9
[125I]exendin-(9-39) Antagonist Antagonist 8.3
exendin-(9-39) Antagonist Antagonist 8.1
T-0632 Antagonist Antagonist 4.7
[125I]exendin None None
glucagon-like peptide-1-(7-37) Agonist Full agonist
exendin-3 Agonist Full agonist
[125I]GLP-1-(7-37) Agonist Full agonist

(29) Novoseek inferred chemical compound relationships for GLP1R Gene

Compound -log(P) Hits PubMed IDs
incretin 95.6 30
exenatide 94.3 31
liraglutide 94.1 19
sitagliptin 89.4 8
glp-1 (7-36)amide 86.5 7

(2) PharmGKB related drug/compound annotations for GLP1R Gene

Drug/compound Annotation
clozapine CA
olanzapine CA
genes like me logo Genes that share compounds with GLP1R: view

Transcripts for GLP1R Gene

mRNA/cDNA for GLP1R Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GLP1R Gene

Glucagon-like peptide 1 receptor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GLP1R Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b · 14c ^ 15
SP1: - -
SP2:
SP3: -
SP4: - - - -

Relevant External Links for GLP1R Gene

GeneLoc Exon Structure for
GLP1R
ECgene alternative splicing isoforms for
GLP1R

Expression for GLP1R Gene

mRNA expression in normal human tissues for GLP1R Gene

mRNA differential expression in normal tissues according to GTEx for GLP1R Gene

This gene is overexpressed in Pancreas (18.8), Heart - Left Ventricle (5.8), and Heart - Atrial Appendage (5.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for GLP1R Gene

SOURCE GeneReport for Unigene cluster for GLP1R Gene Hs.389103

genes like me logo Genes that share expressions with GLP1R: view

Orthologs for GLP1R Gene

This gene was present in the common ancestor of chordates.

Orthologs for GLP1R Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GLP1R 36
  • 98.7 (n)
  • 99.57 (a)
GLP1R 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GLP1R 36
  • 88.86 (n)
  • 91.08 (a)
GLP1R 37
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GLP1R 36
  • 89.95 (n)
  • 90.19 (a)
GLP1R 37
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Glp1r 36
  • 87.19 (n)
  • 92.01 (a)
Glp1r 16
Glp1r 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GLP1R 37
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GLP1R 37
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Glp1r 36
  • 87.04 (n)
  • 90.71 (a)
chicken
(Gallus gallus)
Aves GLP-1R 37
  • 76 (a)
OneToOne
GLP1R 36
  • 74.51 (n)
  • 76.7 (a)
lizard
(Anolis carolinensis)
Reptilia GLP1R 37
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia glp1r 36
  • 73.2 (n)
  • 74.4 (a)
Species with no ortholog for GLP1R:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GLP1R Gene

ENSEMBL:
Gene Tree for GLP1R (if available)
TreeFam:
Gene Tree for GLP1R (if available)

Paralogs for GLP1R Gene

Selected SIMAP similar genes for GLP1R Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GLP1R: view

Variants for GLP1R Gene

Sequence variations from dbSNP and Humsavar for GLP1R Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1820 -- 39,087,645(+) ACCTT(A/T)CCCCA utr-variant-3-prime
rs742761 -- 39,078,879(-) AGGCC(A/G)CCAAT intron-variant
rs742762 -- 39,078,868(-) GCACA(G/T)GGCCA intron-variant
rs742763 -- 39,062,676(-) ATGTG(C/T)CATTC intron-variant
rs742764 -- 39,062,058(+) AGGAG(C/T)TAATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GLP1R Gene

Variant ID Type Subtype PubMed ID
nsv885817 CNV Loss 21882294
nsv885821 CNV Gain 21882294
nsv528286 CNV Gain 19592680
nsv470815 CNV Loss 18288195
nsv519907 CNV Loss 19592680
nsv462919 CNV Loss 19166990

Relevant External Links for GLP1R Gene

HapMap Linkage Disequilibrium report
GLP1R
Human Gene Mutation Database (HGMD)
GLP1R

Disorders for GLP1R Gene

(4) University of Copenhagen DISEASES for GLP1R Gene

(19) Novoseek inferred disease relationships for GLP1R Gene

Disease -log(P) Hits PubMed IDs
insulinoma 73.4 19
niddm 72.7 20
hypoglycemia 64 7
hyperglycemia 56.1 5
obesity 45.9 5

Relevant External Links for GLP1R

Genetic Association Database (GAD)
GLP1R
Human Genome Epidemiology (HuGE) Navigator
GLP1R
genes like me logo Genes that share disorders with GLP1R: view

No data available for UniProtKB/Swiss-Prot for GLP1R Gene

Publications for GLP1R Gene

  1. Cloning and functional expression of the human glucagon-like peptide- 1 (GLP-1) receptor. (PMID: 8404634) Dillon J.S. … Boyd A.E. (Endocrinology 1993) 3 4 23
  2. Signal transduction of the GLP-1-receptor cloned from a human insulinoma. (PMID: 7517895) van Eyll B. … Goeke B. (FEBS Lett. 1994) 3 4 23
  3. Cloning and functional expression of a human glucagon-like peptide-1 receptor. (PMID: 8216285) Graziano M.P. … Strader C.D. (Biochem. Biophys. Res. Commun. 1993) 3 4 23
  4. Five missense mutations in glucagon-like peptide 1 receptor gene in Japanese population. (PMID: 15364163) Tokuyama Y. … Kanatsuka A. (Diabetes Res. Clin. Pract. 2004) 3 23 49
  5. Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain. (PMID: 18287102) Runge S. … Rudolph R. (J. Biol. Chem. 2008) 3 4 23

Products for GLP1R Gene

  • antibodies-online peptides for GLP1R
  • antibodies-online antibodies for GLP1R
  • antibodies-online kits for GLP1R

Sources for GLP1R Gene

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