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GLP1R Gene

protein-coding   GIFtS: 69
GCID: GC06P039063

Glucagon-Like Peptide 1 Receptor

  See GLP1R-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Glucagon-Like Peptide 1 Receptor1 2
GLP-1-R2 3
GLP-1R2 3
GLP-1 Receptor2 3

External Ids:    HGNC: 43241   Entrez Gene: 27402   Ensembl: ENSG000001121647   OMIM: 1380325   UniProtKB: P432203   

Export aliases for GLP1R gene to outside databases

Previous GC identifers: GC06P039018 GC06P039124 GC06P038734


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for GLP1R Gene:
GLP1R (glucagon-like peptide 1 receptor) is a protein-coding gene. Diseases associated with GLP1R include fasting hypoglycemia, and type 2 diabetes mellitus. GO annotations related to this gene include transmembrane signaling receptor activity and glucagon receptor activity. An important paralog of this gene is GHRHR.

UniProtKB/Swiss-Prot: GLP1R_HUMAN, P43220
Function: This is a receptor for glucagon-like peptide 1. The activity of this receptor is mediated by G proteins
which activate adenylyl cyclase

summary for GLP1R Gene:
Glucagon-like peptide 1 (GLP-1) receptors are members of the glucagon receptor family that also includes
glucagon, GLP-2, secretin, GHRH and GIP receptors. GLP-1 receptors are found both centrally (hypothalamus
and brainstem) and peripherally (pancreatic islet cells, stomach and heart). GLP-1 receptors mediate the
effects of the incretin axis; the functional connection between the intestine and the islets of Langerhans
in the pancreas. Activation stimulates insulin release from the islet beta-cells in a glucose-dependent
manner and suppresses glucagon secretion from islet alpha-cells. In addition, GLP-1 receptors delay gastric
emptying and regulate appetite. The human GLP-1 receptor gene is localized on chromosome 6p21.

Gene Wiki entry for GLP1R (Glucagon-like peptide 1 receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the GLP1R gene promoter:
         TBP   Pax-5   AML1a   Pax-6   Olf-1   RORalpha2   MEF-2A   CP2   Chx10   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGLP1R promoter sequence
   Search Chromatin IP Primers for GLP1R

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GLP1R


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21   Ensembl cytogenetic band:  6p21.2   HGNC cytogenetic band: 6p21

GLP1R Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GLP1R gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P039063:  view genomic region     (about GC identifiers)

Start:
39,016,557 bp from pter      End:
39,055,520 bp from pter
Size:
38,964 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: GLP1R_HUMAN, P43220 (See protein sequence)
Recommended Name: Glucagon-like peptide 1 receptor precursor  
Size: 463 amino acids; 53026 Da
Subunit: May form homodimers and heterodimers with GIPR
3 PDB 3D structures from and Proteopedia for GLP1R:
3C59 (3D)        3C5T (3D)        3IOL (3D)    
Secondary accessions: Q2M229 Q99669

Explore the universe of human proteins at neXtProt for GLP1R: NX_P43220

Explore proteomics data for GLP1R at MOPED

Post-translational modifications: 

  • N-glycosylation enhances cell surface expression and lengthens receptor half-life by preventing degradation in the
    ER1
  • Glycosylation2 at Asn63, Asn82, Asn115
  • Modification sites at PhosphoSitePlus

  • See GLP1R Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002053.3  
    ENSEMBL proteins: 
     ENSP00000362353  
    Reactome Protein details: P43220

    GLP1R Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GCGR: GPCR / Class B : Glucagon receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: GLP-1 receptor
    Glucagon receptor family

    Selected InterPro protein domains (see all 6):
     IPR001879 GPCR_2_extracellular_dom
     IPR003290 GPCR_2_GLP1/glucagon_rcpt
     IPR000832 GPCR_2_secretin-like
     IPR003292 GPCR_2_GLP1_rcpt
     IPR017983 GPCR_2_secretin-like_CS

    Graphical View of Domain Structure for InterPro Entry P43220

    ProtoNet protein and cluster: P43220

    3 Blocks protein domains:
    IPB000832 G-protein coupled receptors family 2 (secretin-like)
    IPB003290 Glucagon family receptor signature
    IPB003292 Glucagon-like peptide 1 receptor signature


    UniProtKB/Swiss-Prot: GLP1R_HUMAN, P43220
    Similarity: Belongs to the G-protein coupled receptor 2 family


    Find genes that share domains with GLP1R           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GLP1R_HUMAN, P43220
    Function: This is a receptor for glucagon-like peptide 1. The activity of this receptor is mediated by G proteins
    which activate adenylyl cyclase

         Genatlas biochemistry entry for GLP1R:
    glucagon-like peptide 1,receptor,G protein coupled receptor superfamily,mediating the insulinotropic effect of the
    incretin hormone GLP1,regulated by SP1 and SP3

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity TAS8405712
    GO:0004930G-protein coupled receptor activity ----
    GO:0004967glucagon receptor activity IEA--
         
    Find genes that share ontologies with GLP1R           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for GLP1R:
     Proliferating cells 

         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Glp1r):
     adipose tissue  behavior/neurological  endocrine/exocrine gland  growth/size/body  homeostasis/metabolism 

    Find genes that share phenotypes with GLP1R           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Glp1rtm1Ddr for GLP1R

       genOway: Develop your customized and physiologically relevant rodent model for GLP1R

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    hsa-miR-1224-3p hsa-miR-1260b hsa-miR-3921 hsa-miR-192 hsa-miR-650 hsa-miR-637 hsa-miR-215 hsa-miR-3153
    SwitchGear 3'UTR luciferase reporter plasmidGLP1R 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GLP1R_HUMAN, P43220: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus2
    endoplasmic reticulum1
    extracellular1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with GLP1R           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GLP1R About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Integration of energy metabolism
    Integration of energy metabolism0.75
    Regulation of Insulin Secretion by Glucagon-like Peptide-10.56
    Regulation of Insulin Secretion0.75
    4ADP signalling through P2Y purinoceptor 12
    Glucagon-type ligand receptors0.61
    Class B/2 (Secretin family receptors)0.36
    5Metabolism
    Metabolism0.38


    Find genes that share SuperPaths with GLP1R           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for GLP1R
        GPCRs, Class B Secretin-like


    3 Reactome Pathways for GLP1R
        Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
    Glucagon-type ligand receptors
    G alpha (s) signalling events


    2 Kegg Pathways  (Kegg details for GLP1R):
        Neuroactive ligand-receptor interaction
    Insulin secretion

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GLP1R: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Obesity in human mouse rat
              Diabetes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for GLP1R

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GLP1R (P432202, 3 ENSP000003623534) via UniProtKB, MINT, STRING, and/or I2D (see all 72)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM2P621582, 3MINT-51640 I2D: score=3 
    CALM3P621582, 3MINT-51640 I2D: score=3 
    CALM1P621582, 3, ENSP000003494674MINT-51640 I2D: score=3 STRING: ENSP00000349467
    GPRASP1Q5JY773, ENSP000003551464I2D: score=1 STRING: ENSP00000355146
    GCGP012753, ENSP000003876624I2D: score=2 STRING: ENSP00000387662
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006112energy reserve metabolic process TAS--
    GO:0007166cell surface receptor signaling pathway ----
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007190activation of adenylate cyclase activity TAS8405712
    GO:0007204positive regulation of cytosolic calcium ion concentration IDA7589461

    Find genes that share ontologies with GLP1R           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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      Browse compounds at ApexBio 

    Compounds for GLP1R available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Exendin-3 (9-39) amidePotent GLP-1 receptor antagonist[133514-43-9]
    Glucagon-like peptide 1 (7-36) amide (human, rat) Potent insulinotropic peptide[107444-51-9]
    Exendin-4Potent GLP-1 receptor agonist[141758-74-9]
    GLP-1 (9-36) amideMetabolite of GLP-1-(7-36) (Cat. No. 2082)[161748-29-4]
    Glucagon-like peptide 1 (1-37) (human, rat) Endogenous pancreatic peptide[87805-34-3]

    3 DrugBank Compounds for GLP1R    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    ExenatideAC2993 (see all 2)141758-74-9targetagonist20649595 15495988 15700891 17379930 16627399 17292977 16341288 15331551 11752352 16534527 17353295 16722815
    Glucagon recombinant-- 9007-92-5target--17534934 17498508 12529935 17475961
    LiraglutideArg34Lys26-(N-ε-(γ-Glu(N-α-hexadecanoyl)))-GLP-1[7-37] (see all 6)204656-20-2targetagonist14678021 18333889

    Selected IUPHAR Ligands for GLP1R (GLP-1 receptor) (see all 12)    About this table
    LigandTypeActionAffinityPubmed IDs
    liraglutide
    AgonistFull agonist10.210794683
    [125I]GLP-1-(7-36)-amide
    AgonistFull agonist9.315528268
    glucagon-like peptide 1-(7-36) amide
    AgonistFull agonist9.215528268
    exendin-4
    AgonistFull agonist8.7 - 915528268
    [125I]exendin-(9-39)
    AntagonistAntagonist8.315528268
    exendin-(9-39)
    AntagonistAntagonist8.115528268
    glucagon
    AgonistFull agonist6.9 - 715528268
    T-0632
    AntagonistAntagonist4.711498540
    [125I]exendin
    NoneNone4.7--
    glucagon-like peptide-1-(7-37)
    AgonistFull agonist4.78404634

    Selected Novoseek inferred chemical compound relationships for GLP1R gene (see all 29)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    incretin 95.6 37 10096792 (1), 19545590 (1), 20465123 (1), 16902971 (1) (see all 30)
    exenatide 94.3 32 16722815 (2), 17292977 (2), 17201111 (1), 18786299 (1) (see all 29)
    liraglutide 94.1 20 15796922 (2), 15780433 (1), 19878257 (1), 20518802 (1) (see all 18)
    sitagliptin 89.4 8 18786299 (1), 20518802 (1), 17877544 (1), 18840004 (1) (see all 8)
    glp-1 (7-36)amide 86.5 7 9149306 (2), 20018525 (1), 8762106 (1), 9730951 (1) (see all 6)
    vildagliptin 83.6 5 20518802 (1), 17877544 (1), 18840004 (1), 19801361 (1) (see all 5)
    saxagliptin 80 2 20518802 (1), 19801361 (1)
    proglucagon 79.7 1 9223287 (1)
    oxyntomodulin 70.8 7 17395766 (3), 19359390 (1), 20147608 (1), 19074579 (1)
    glucose 70.1 86 9220027 (7), 18487451 (3), 18426860 (2), 19672815 (2) (see all 50)

    2 PharmGKB related drug/compound annotations for GLP1R gene    About this table
    Drug/compound PharmGKB Annotation
    clozapineCA  
    olanzapineCA  



    Find genes that share compounds with GLP1R           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GLP1R gene: 
    NM_002062.3  

    Unigene Cluster for GLP1R:

    Glucagon-like peptide 1 receptor
    Hs.389103  [show with all ESTs]
    Unigene Representative Sequence: NM_002062
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000373256(uc003ooh.2 uc003ooi.2 uc003ooj.4)
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    Additional mRNA sequence: 

    BC112126.1 BC113493.1 L23503.1 U01104.1 U01156.1 U01157.1 U10037.1 

    3 DOTS entries:

    DT.87046754  DT.92416321  DT.75157029 

    11 AceView cDNA sequences:

    L23503 BX102509 NM_002062 BG675444 U01157 AW294725 BV203774 U01156 
    U01104 AI911512 U10037 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for GLP1R    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b · 14c ^ 15
    SP1:                                                                                            -     -                     
    SP2:                                                                                                                        
    SP3:                                                                                            -                           
    SP4:                                                                                            -     -     -     -         


    ECgene alternative splicing isoforms for GLP1R

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GLP1R expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGATGTGCAA
    GLP1R Expression
    About this image

    GLP1R Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GLP1R Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.389103
        Pathway & Disease-focused RT2 Profiler PCR Arrays including GLP1R: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Obesity in human mouse rat
              Diabetes in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for GLP1R gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Glp1r1 , 5 glucagon-like peptide 1 receptor1, 5 87.19(n)1
    92.01(a)1
      17 (15.80 cM)5
    146521  NM_021332.21  NP_067307.21 
     309018675 
    chicken
    (Gallus gallus)
    Aves GLP1R1 glucagon-like peptide 1 receptor 74.51(n)
    76.7(a)
      428573  NM_001135551.1  NP_001129023.1 
    lizard
    (Anolis carolinensis)
    Reptilia GLP1R6
    glucagon-like peptide 1 receptor
    66(a)
    1 ↔ 1
    1(246318330-246392305)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia glp1r1 glucagon-like peptide 1 receptor 73.2(n)
    74.4(a)
      101734463  XM_004919837.1  XP_004919894.1 


    ENSEMBL Gene Tree for GLP1R (if available)
    TreeFam Gene Tree for GLP1R (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GLP1R gene
    GHRHR2  GCGR2  CALCR2  PTH1R2  CRHR22  VIPR12  CRHR12  PTH2R2  
    CALCRL2  SCTR2  ADCYAP1R12  GLP2R2  VIPR22  GIPR2  
    12 SIMAP similar genes for GLP1R using alignment to 1 protein entry:     GLP1R_HUMAN:
    GLP2R    GCGR    GIPR    SCTR    VIPR2    PTH1R
    VIPR1    CALCRL    CALCR    PTH2R    GHRHR    CRHR2

    Find genes that share paralogs with GLP1R           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GLP1R (see all 1288)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1863633221,2
    --39014645(+) ATCCCC/TAGGAC 1 -- us2k10--------
    rs1387275411,2
    C--39014654(+) ACCTAC/GAATGG 1 -- us2k10--------
    rs734144031,2
    C,F--39014672(+) CACATG/AGTAGG 1 -- us2k14Minor allele frequency- A:0.05WA NA 242
    rs1493684181,2
    C--39014720(+) GGCTGA/GCAAAT 1 -- us2k10--------
    rs1128407671,2
    C,F--39014792(+) CACCCC/TAAACT 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1404850701,2
    --39014834(+) TATCTG/TTTTTA 1 -- us2k10--------
    rs1428254031,2
    --39014945(+) TGCCTA/GTGTGA 1 -- us2k10--------
    rs793937321,2
    F--39014959(+) AGTTCT/GGAGCA 1 -- us2k11Minor allele frequency- G:0.07WA 118
    rs103054121,2
    C,F,H--39015099(+) tcatgA/Tggtgg 1 -- us2k16Minor allele frequency- T:0.01NS EA 762
    rs92962741,2
    C,F,A,H--39015118(+) GACCAA/GAGGAT 1 -- us2k128Minor allele frequency- G:0.31NS EA NA WA CSA 3171

    HapMap Linkage Disequilibrium report for GLP1R (39016557 - 39055520 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for GLP1R:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv885817CNV Loss21882294
    nsv462919CNV Loss19166990
    nsv470815CNV Loss18288195
    nsv519907CNV Loss19592680
    nsv885821CNV Gain21882294
    nsv528286CNV Gain19592680

    Human Gene Mutation Database (HGMD): GLP1R
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GLP1R
    DNA2.0 Custom Variant and Variant Library Synthesis for GLP1R

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 138032    OMIM disorders: --

    2 diseases for GLP1R:    
    About MalaCards
    fasting hypoglycemia    type 2 diabetes mellitus

    4 diseases from the University of Copenhagen DISEASES database for GLP1R:
    Diabetes mellitus     Hypoglycemia     Hyperglycemia     Insulinoma

    Find genes that share disorders with GLP1R           About GenesLikeMe

    Selected Novoseek inferred disease relationships for GLP1R gene (see all 19)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    insulinoma 73.4 32 19820010 (6), 17575235 (2), 8190093 (1), 18977255 (1) (see all 13)
    niddm 72.7 24 8392011 (2), 7983806 (2), 9397146 (2), 7958545 (2) (see all 16)
    hypoglycemia 64 7 19318378 (2), 19444259 (1), 19624785 (1), 19801361 (1) (see all 6)
    hyperglycemia 56.1 6 19878258 (2), 18487451 (1), 19758106 (1), 19299027 (1)
    obesity 45.9 6 10078851 (2), 10207720 (1), 17940423 (1), 17395766 (1)
    gastrinoma 43.3 1 12707737 (1)
    insulin resistance 40.2 1 19921118 (1)
    hyperinsulinemia 36.1 1 17306374 (1)
    metabolic disorder 28.7 3 18248821 (1), 19772917 (1)
    neuroendocrine tumors 27 2 17475961 (1), 17043625 (1)

    Genetic Association Database (GAD): GLP1R
    Human Genome Epidemiology (HuGE) Navigator: GLP1R (10 documents)

    Export disorders for GLP1R gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GLP1R gene, integrated from 10 sources (see all 350):
    (articles sorted by number of sources associating them with GLP1R)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. GLP-1 receptor expression in human tumors and human normal tissues: potential for in vivo targeting. (PubMed id 17475961)1, 7, 9 KAPrner M....Reubi J.C. (J. Nucl. Med. 2007)
    2. Cloning and functional expression of a human glucagon-like peptide-1 receptor. (PubMed id 8216285)1, 2, 9 Graziano M.P.... Strader C.D. (Biochem. Biophys. Res. Commun. 1993)
    3. Five missense mutations in glucagon-like peptide 1 receptor gene in Japanese population. (PubMed id 15364163)1, 4, 9 Tokuyama Y....Kanatsuka A. (Diabetes Res. Clin. Pract. 2004)
    4. Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain. (PubMed id 18287102)1, 2, 9 Runge S.... Rudolph R. (J. Biol. Chem. 2008)
    5. Signal transduction of the GLP-1-receptor cloned from a human insulinoma. (PubMed id 7517895)1, 2, 9 van Eyll B.... Goeke B. (FEBS Lett. 1994)
    6. Cloning and functional expression of the human glucagon-like peptide- 1 (GLP-1) receptor. (PubMed id 8404634)1, 2, 9 Dillon J.S.... Boyd A.E. (Endocrinology 1993)
    7. Cloning and characterization of the 5' flanking sequences (promoter region) of the human GLP-1 receptor gene. (PubMed id 9213353)1, 2, 9 Lankat-Buttgereit B. and Goeke B. (Peptides 1997)
    8. Regulation of GIP and GLP1 receptor cell surface expression by N- glycosylation and receptor heteromerization. (PubMed id 22412906)1, 2 Whitaker G.M.... Accili E.A. (PLoS ONE 2012)
    9. The major determinant of exendin-4/glucagon-like peptide 1 differential affinity at the rat glucagon-like peptide 1 receptor N-terminal domain is a hydrogen bond from SER-32 of exendin-4. (PubMed id 20649595)1, 7 Mann R.J....Donnelly D. (Br. J. Pharmacol. 2010)
    10. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2740 HGNC: 4324 AceView: GLP1R Ensembl:ENSG00000112164 euGenes: HUgn2740
    ECgene: GLP1R Kegg: 2740 H-InvDB: GLP1R

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GLP1R Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/glp1r/
    Wikipedia http://en.wikipedia.org/wiki/Glucagon-like_peptide-1

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GLP1R gene:
    Search GeneIP for patents involving GLP1R

    Licensable Technologies for GLP1R gene:
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