Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GLP1R Gene

Aliases for GLP1R Gene

  • Glucagon Like Peptide 1 Receptor 2 3 5
  • GLP-1 Receptor 3 4
  • GLP-1-R 3 4
  • GLP-1R 3 4
  • Seven Transmembrane Helix Receptor 3
  • Glucagon-Like Peptide 1 Receptor 2
  • Glucagon-Like Peptide-1 Receptor 3
  • GLP1 Receptor 3
  • GLP-1 3

External Ids for GLP1R Gene

Previous GeneCards Identifiers for GLP1R Gene

  • GC06P039018
  • GC06P039063
  • GC06P039124
  • GC06P038734

Summaries for GLP1R Gene

Entrez Gene Summary for GLP1R Gene

  • This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]

GeneCards Summary for GLP1R Gene

GLP1R (Glucagon Like Peptide 1 Receptor) is a Protein Coding gene. Diseases associated with GLP1R include Insulinoma and Fasting Hypoglycemia. Among its related pathways are cAMP signaling pathway and Presynaptic function of Kainate receptors. GO annotations related to this gene include G-protein coupled receptor activity and glucagon receptor activity. An important paralog of this gene is MGC57346-CRHR1.

UniProtKB/Swiss-Prot for GLP1R Gene

  • This is a receptor for glucagon-like peptide 1. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Tocris Summary for GLP1R Gene

  • Glucagon-like peptide 1 (GLP-1) receptors are members of the glucagon receptor family that also includes glucagon, GLP-2, secretin, GHRH and GIP receptors. GLP-1 receptors are found both centrally and peripherally. GLP-1 receptors mediate the effects of the incretin axis.

Gene Wiki entry for GLP1R Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLP1R Gene

Genomics for GLP1R Gene

Regulatory Elements for GLP1R Gene

Enhancers for GLP1R Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GLP1R on UCSC Golden Path with GeneCards custom track

Promoters for GLP1R Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GLP1R on UCSC Golden Path with GeneCards custom track

Genomic Location for GLP1R Gene

39,048,781 bp from pter
39,091,303 bp from pter
42,523 bases
Plus strand

Genomic View for GLP1R Gene

Genes around GLP1R on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GLP1R Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GLP1R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLP1R Gene

Proteins for GLP1R Gene

  • Protein details for GLP1R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Glucagon-like peptide 1 receptor
    Protein Accession:
    Secondary Accessions:
    • Q2M229
    • Q99669

    Protein attributes for GLP1R Gene

    463 amino acids
    Molecular mass:
    53026 Da
    Quaternary structure:
    • May form homodimers and heterodimers with GIPR.

    Three dimensional structures from OCA and Proteopedia for GLP1R Gene

neXtProt entry for GLP1R Gene

Proteomics data for GLP1R Gene at MOPED

Post-translational modifications for GLP1R Gene

  • N-glycosylation enhances cell surface expression and lengthens receptor half-life by preventing degradation in the ER.
  • Glycosylation at Asn 63, Asn 82, and Asn 115
  • Modification sites at PhosphoSitePlus

Other Protein References for GLP1R Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for GLP1R Gene

Domains & Families for GLP1R Gene

Gene Families for GLP1R Gene

Suggested Antigen Peptide Sequences for GLP1R Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 2 family.
  • Belongs to the G-protein coupled receptor 2 family.
genes like me logo Genes that share domains with GLP1R: view

Function for GLP1R Gene

Molecular function for GLP1R Gene

GENATLAS Biochemistry:
glucagon-like peptide 1,receptor,G protein coupled receptor superfamily,mediating the insulinotropic effect of the incretin hormone GLP1,regulated by SP1 and SP3
UniProtKB/Swiss-Prot Function:
This is a receptor for glucagon-like peptide 1. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
genes like me logo Genes that share phenotypes with GLP1R: view

Animal Models for GLP1R Gene

MGI Knock Outs for GLP1R:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GLP1R Gene

Localization for GLP1R Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLP1R Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for GLP1R Gene COMPARTMENTS Subcellular localization image for GLP1R gene
Compartment Confidence
cytosol 5
plasma membrane 5
extracellular 2
nucleus 2
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for GLP1R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with GLP1R: view

Pathways & Interactions for GLP1R Gene

genes like me logo Genes that share pathways with GLP1R: view

SIGNOR curated interactions for GLP1R Gene

Is activated by:

Gene Ontology (GO) - Biological Process for GLP1R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006112 energy reserve metabolic process TAS --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007611 learning or memory IEA --
GO:0008016 regulation of heart contraction IEA --
genes like me logo Genes that share ontologies with GLP1R: view

Drugs & Compounds for GLP1R Gene

(52) Drugs for GLP1R Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Liraglutide Approved Pharma Full agonist, Agonist, agonist, Target 281
Exenatide Approved, Investigational Pharma binder, Target, agonist 276
Albiglutide Approved Pharma activator, Target, agonist 0
Dulaglutide Approved Pharma Target, agonist 38
Glucagon recombinant Approved Pharma Target 0

(19) Additional Compounds for GLP1R Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Full agonist, Agonist
glucagon-like peptide-1-(7-37)
Full agonist, Agonist
Exendin-3 (9-39) amide
GLP-1 (7-37)

(5) Tocris Compounds for GLP1R Gene

Compound Action Cas Number
Exendin-3 (9-39) amide Potent GLP-1 receptor antagonist 133514-43-9
Exendin-4 Potent GLP-1 receptor agonist 141758-74-9
GLP-1 (7-37) Endogenous bioactive GLP-1 receptor ligand 106612-94-6
Glucagon-like peptide 1 (1-37) (human, rat) Endogenous pancreatic peptide 87805-34-3
Glucagon-like peptide 1 (7-36) amide (human, rat) Potent insulinotropic peptide 107444-51-9

(1) ApexBio Compounds for GLP1R Gene

Compound Action Cas Number
BIX 01294 G9a and GLP inhibitor 935693-62-2
genes like me logo Genes that share compounds with GLP1R: view

Drug Products

Transcripts for GLP1R Gene

mRNA/cDNA for GLP1R Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GLP1R Gene

Glucagon-like peptide 1 receptor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GLP1R Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b · 14c ^ 15
SP1: - -
SP3: -
SP4: - - - -

Relevant External Links for GLP1R Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GLP1R Gene

mRNA expression in normal human tissues for GLP1R Gene

mRNA differential expression in normal tissues according to GTEx for GLP1R Gene

This gene is overexpressed in Pancreas (x18.8), Heart - Left Ventricle (x5.8), and Heart - Atrial Appendage (x5.7).

Protein differential expression in normal tissues from HIPED for GLP1R Gene

This gene is overexpressed in Platelet (32.1) and Fetal testis (31.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GLP1R Gene

SOURCE GeneReport for Unigene cluster for GLP1R Gene Hs.389103

genes like me logo Genes that share expression patterns with GLP1R: view

Protein tissue co-expression partners for GLP1R Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for GLP1R Gene

Orthologs for GLP1R Gene

This gene was present in the common ancestor of chordates.

Orthologs for GLP1R Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GLP1R 35
  • 88.86 (n)
  • 91.08 (a)
GLP1R 36
  • 87 (a)
(Canis familiaris)
Mammalia GLP1R 35
  • 89.95 (n)
  • 90.19 (a)
GLP1R 36
  • 76 (a)
(Mus musculus)
Mammalia Glp1r 35
  • 87.19 (n)
  • 92.01 (a)
Glp1r 16
Glp1r 36
  • 92 (a)
(Pan troglodytes)
Mammalia GLP1R 35
  • 98.7 (n)
  • 99.57 (a)
GLP1R 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Glp1r 35
  • 87.04 (n)
  • 90.71 (a)
(Monodelphis domestica)
Mammalia GLP1R 36
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia GLP1R 36
  • 73 (a)
(Gallus gallus)
Aves GLP1R 35
  • 74.51 (n)
  • 76.7 (a)
GLP-1R 36
  • 76 (a)
(Anolis carolinensis)
Reptilia GLP1R 36
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia glp1r 35
  • 73.2 (n)
  • 74.4 (a)
Species with no ortholog for GLP1R:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GLP1R Gene

Gene Tree for GLP1R (if available)
Gene Tree for GLP1R (if available)

Paralogs for GLP1R Gene

(12) SIMAP similar genes for GLP1R Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GLP1R: view

Variants for GLP1R Gene

Sequence variations from dbSNP and Humsavar for GLP1R Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1042044 - 39,073,726(+) GTCTT(A/C/T)TCTGA nc-transcript-variant, reference, missense
rs10305420 - 39,048,860(+) CGGCC(C/T)GCTGC nc-transcript-variant, reference, missense
rs10305421 - 39,048,899(+) GGGCA(A/G)GGCCG nc-transcript-variant, reference, missense
rs2295006 - 39,056,449(-) ACTGG(C/T)GTCGG nc-transcript-variant, reference, missense
rs3765467 - 39,065,819(-) CCCCT(A/C/G/T)GCTTG nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for GLP1R Gene

Variant ID Type Subtype PubMed ID
nsv885817 CNV Loss 21882294
nsv885821 CNV Gain 21882294
nsv528286 CNV Gain 19592680
nsv470815 CNV Loss 18288195
nsv519907 CNV Loss 19592680
nsv462919 CNV Loss 19166990

Variation tolerance for GLP1R Gene

Residual Variation Intolerance Score: 72.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.08; 87.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GLP1R Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLP1R Gene

Disorders for GLP1R Gene

MalaCards: The human disease database

(11) MalaCards diseases for GLP1R Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • islet cell tumor
fasting hypoglycemia
pneumatosis cystoides intestinalis
  • hypoglycaemia
endocrine pancreas disease
  • disorder of endocrine pancreas
- elite association - COSMIC cancer census association via MalaCards
Search GLP1R in MalaCards View complete list of genes associated with diseases

Relevant External Links for GLP1R

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GLP1R: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GLP1R Gene

Publications for GLP1R Gene

  1. Cloning and functional expression of a human glucagon-like peptide-1 receptor. (PMID: 8216285) Graziano M.P. … Strader C.D. (Biochem. Biophys. Res. Commun. 1993) 3 4 23 67
  2. GLP-1 receptor expression in human tumors and human normal tissues: potential for in vivo targeting. (PMID: 17475961) KAPrner M. … Reubi J.C. (J. Nucl. Med. 2007) 3 23 25
  3. Crystal structure of glucagon-like peptide-1 in complex with the extracellular domain of the glucagon-like peptide-1 receptor. (PMID: 19861722) Underwood C.R. … Reedtz-Runge S. (J. Biol. Chem. 2010) 3 23
  4. Role of the signal peptide in the synthesis and processing of the glucagon-like peptide-1 receptor. (PMID: 20002095) Huang Y. … Willars G.B. (Br. J. Pharmacol. 2010) 3 23
  5. Glucagon-like peptide-1 receptor is present on human hepatocytes and has a direct role in decreasing hepatic steatosis in vitro by modulating elements of the insulin signaling pathway. (PMID: 20225248) Gupta N.A. … Anania F.A. (Hepatology 2010) 3 23

Products for GLP1R Gene

Sources for GLP1R Gene