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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GLO1 Gene

protein-coding   GIFtS: 68
GCID: GC06M038643

Glyoxalase I

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Glyoxalase I1 2 3     GLYI2
Glyoxalase Domain Containing 11 2     aldoketomutase2
Glx I2 3     Lactoyl Glutathione Lyase2
Ketone-Aldehyde Mutase2 3     Lactoylglutathione Lyase2
S-D-Lactoylglutathione Methylglyoxal Lyase2 3     methylglyoxalase2
EC 4.4.1.53 8     Aldoketomutase3
GLOD12     Methylglyoxalase3

External Ids:    HGNC: 43231   Entrez Gene: 27392   Ensembl: ENSG000001247677   OMIM: 1387505   UniProtKB: Q047603   

Export aliases for GLO1 gene to outside databases

Previous GC identifers: GC06M038645 GC06M038690 GC06M038751 GC06M038361


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GLO1 Gene:
The enzyme encoded by this gene is responsible for the catalysis and formation of S-lactoyl-glutathione from
methylglyoxal condensation and reduced glutatione. Glyoxalase I is linked to HLA and is localized to
6p21.3-p21.1, between HLA and the centromere. (provided by RefSeq, Jul 2008)

GeneCards Summary for GLO1 Gene: 
GLO1 (glyoxalase I) is a protein-coding gene. Diseases associated with GLO1 include paracoccidioidomycosis, and hyperglycemia, and among its related super-pathways are methylglyoxal degradation VI. GO annotations related to this gene include lactoylglutathione lyase activity and metal ion binding.

UniProtKB/Swiss-Prot: LGUL_HUMAN, Q04760
Function: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to
S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B

Gene Wiki entry for GLO1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GLO1 gene promoter:
         GR   STAT1   p53   HNF-3beta   C/EBPalpha   AREB6   Ik-2   FOXO4   STAT3   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGLO1 promoter sequence
   Search SABiosciences Chromatin IP Primers for GLO1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GLO1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3-p21.1   Ensembl cytogenetic band:  6p21.2   HGNC cytogenetic band: 6p21.3-p21.1

GLO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GLO1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M038643:  view genomic region     (about GC identifiers)

Start:
38,643,701 bp from pter      End:
38,670,952 bp from pter
Size:
27,252 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LGUL_HUMAN, Q04760 (See protein sequence)
Recommended Name: Lactoylglutathione lyase  
Size: 184 amino acids; 20778 Da
Cofactor: Binds 1 zinc ion per subunit
Subunit: Homodimer
Mass spectrometry: Mass=20687.4; Method=Electrospray; Range=2-184 (Q04760-1); Note=Variant Glu-111;
Source=PubMed:20454679;
Mass spectrometry: Mass=20629.7; Method=Electrospray; Range=2-184 (Q04760-1); Note=Variant Ala-111;
Source=PubMed:20454679;
Sequence caution: Sequence=BAD93038.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
5 PDB 3D structures from and Proteopedia for GLO1:
1BH5 (3D)        1FRO (3D)        1QIN (3D)        1QIP (3D)        3VW9 (3D)    
Secondary accessions: B2R6P7 B4DDV0 P78375 Q59EL0 Q5TZW3 Q96FC0 Q96J41
Alternative splicing: 2 isoforms:  Q04760-1   Q04760-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for GLO1: NX_Q04760

Explore proteomics data for GLO1 at MOPED 

Post-translational modifications:

  • UniProtKB: Glutathionylation at Cys-139 inhibits enzyme activity
  • UniProtKB: Phosphorylated at Thr-107 in the presence of CaMK2. However, this is a consensus site for phosphorylation by CK2
    so phosphorylation may be mediated by CK2 rather than CaMK2. Phosphorylation is induced by TNF and suppresses the
    TNF-induced transcriptional activity of NF-kappa-B
  • UniProtKB: Exists in a nitric oxide (NO)-modified form. The exact nature of the modification is unknown, but it suppresses
    the TNF-induced transcriptional activity of NF-kappa-B
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q04760

  • 4/7 DME Specific Peptides for GLO1 (Q04760) (see all 7)
     PDGYWIE  RFEELGV  ELTHNWGT  KSLDFYTRVLG 

    GLO1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GLO1 Protein Expression
    REFSEQ proteins: NP_006699.2  
    ENSEMBL proteins: 
     ENSP00000362463  

    Human Recombinant Protein Products for GLO1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Novus Biologicals GLO1 Proteins
    Novus Biologicals GLO1 Lysate
    Sino Biological Recombinant Protein for GLO1
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for GLO1
    Cloud-Clone Corp. Proteins for GLO1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm TAS16130169

    GLO1 for ontologies           About GeneDecksing



    GLO1 Antibody Products: 
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    Assay Products for GLO1: 
    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GLO1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for GLO1 
    Cloud-Clone Corp. CLIAs for GLO1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR018146 Glyoxalase_1_CS
     IPR004361 Glyoxalase_1
     IPR004360 Glyas_Fos-R_dOase_dom

    Graphical View of Domain Structure for InterPro Entry Q04760

    ProtoNet protein and cluster: Q04760

    3 Blocks protein domains:
    IPB004360 Glyoxalase/Bleomycin resistance protein/dioxygenase domain
    IPB004361 Glyoxalase I
    IPB011588 Glyoxalase/extradiol ring-cleavage dioxygenase


    UniProtKB/Swiss-Prot: LGUL_HUMAN, Q04760
    Similarity: Belongs to the glyoxalase I family


    GLO1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LGUL_HUMAN, Q04760
    Function: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to
    S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B
    Catalytic activity: (R)-S-lactoylglutathione = glutathione + methylglyoxal
    Enzyme regulation: Regulated by oxidation of Cys-139 in response to the redox state of the cell. Results in the
    alternative formation of cystine or glutathione-bound cysteine, the latter modification leading to reduced enzyme
    activity
    Biophysicochemical properties: Kinetic parameters: KM=1.3 mM for methylglyoxal/glutathione (native form); KM=0.7
    mM for methylglyoxal/glutathione (reduced form); Vmax=0.335 umol/min/mg enzyme with methylglyoxal/glutathione as
    substrate (native form); Vmax=0.7 umol/min/mg enzyme with methylglyoxal/glutathione as substrate (reduced form);
    Note=Reduction of GLO1 was carried out by incubation with 20 mM betamercaptoethanol prior to kinetic analysis;

         Genatlas biochemistry entry for GLO1:
    glyoxalase I

         Enzyme Number (IUBMB): EC 4.4.1.51 2

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004462lactoylglutathione lyase activity IDA11489834
    GO:0046872metal ion binding IEA--
         
    GLO1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for GLO1:
     Decreased POU5F1-GFP protein e  Increased HPV18 LCR reporter a 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for GLO1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GLO1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GLO1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GLO1 

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    SwitchGear 3'UTR luciferase reporter plasmidGLO1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GLO1
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                         Customized lentivirus expression plasmids for stable overexpression of GLO1 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GLO1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GLO1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1methylglyoxal degradation I
    methylglyoxal degradation I0.50
    2Pyruvate metabolism
    Pyruvate metabolism

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for GLO1
        methylglyoxal degradation I



    1         Kegg Pathway  (Kegg details for GLO1):
        Pyruvate metabolism

    UniProtKB/Swiss-Prot: LGUL_HUMAN, Q04760
    Pathway: Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2


    GLO1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GLO1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    5/37 Interacting proteins for GLO1 (Q047603 ENSP000003624634) via UniProtKB, MINT, STRING, and/or I2D (see all 37)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP1LC3BQ9GZQ83, ENSP000002686074I2D: score=1 STRING: ENSP00000268607
    IKBKEQ141643, ENSP000003560874I2D: score=1 STRING: ENSP00000356087
    ATG16L1Q676U53I2D: score=1 
    ATG5Q9H1Y03I2D: score=1 
    CAMKK2Q96RR43I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006749glutathione metabolic process IEA--
    GO:0009438methylglyoxal metabolic process IEA--
    GO:0043066negative regulation of apoptotic process TAS16130169

    GLO1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GLO1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GLO1 (LGUL)

    3 HMDB Compounds for GLO1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 32)70-18-8--
    Pyruvaldehyde1,2-Propanedione (see all 16)78-98-8--
    S-Lactoylglutathione(R)-S-lactoylglutathione (see all 13)25138-66-3--

    8 DrugBank Compounds for GLO1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Beta-Mercaptoethanol-- 60-24-2target--17139284 17016423
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 5)70-18-8target--17664277 17609286
    S-(N-Hydroxy-N-Iodophenylcarbamoyl)Glutathione-- --target--17139284 17016423
    S-Benzyl-Glutathione-- --target--17139284 17016423
    S-Hexylglutathione-- --target--17139284 17016423
    S-P-Nitrobenzyloxycarbonylglutathione-- --target--17139284 17016423
    IndomethacinIMN (see all 9)53-86-1targetinhibitor17243824
    methyl 4-(2,3-dihydroxy-5-methylphenoxy)-2-hydroxy-6-methylbenzoate-- --target--10592235

    10/55 Novoseek inferred chemical compound relationships for GLO1 gene (see all 55)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    methylglyoxal 95.3 111 20204770 (4), 7859825 (3), 20093988 (3), 8636255 (2) (see all 64)
    s-d-lactoylglutathione 94.9 14 11459475 (1), 18448828 (1), 19062100 (1), 17110973 (1) (see all 12)
    s-(p-bromobenzyl)glutathione 94.1 7 10206549 (1), 8304987 (1), 8787553 (1), 8489699 (1) (see all 6)
    2-crotonyloxymethyl-2-cyclohexenone 89.5 4 11975603 (1), 11922820 (1)
    s-p-nitrobenzoxycarbonylglutathione 86.3 2 1472100 (1), 8489699 (1)
    tlk 199 79.2 1 7619046 (1)
    s-hexylglutathione 75.3 3 9359858 (1), 8489699 (1)
    glyoxal 73.9 7 14641060 (2), 16037241 (2), 16427160 (1), 20102351 (1) (see all 5)
    cotc 73.7 3 15686923 (2), 11922820 (1)
    6-phosphogluconate 65.3 9 2129617 (1), 12503751 (1), 1532788 (1), 1493913 (1) (see all 7)

    Search CenterWatch for drugs/clinical trials and news about GLO1 / LGUL

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GLO1 gene: 
    NM_006708.2  

    Unigene Cluster for GLO1:

    Glyoxalase I
    Hs.268849  [show with all ESTs]
    Unigene Representative Sequence: NM_006708
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373365(uc003ooc.3) ENST00000470973
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate GLO1 (see all 10):
    hsa-miR-4303 hsa-miR-576-5p hsa-miR-944 hsa-miR-3179 hsa-miR-146a* hsa-miR-302f hsa-miR-4310 hsa-miR-205*
    SwitchGear 3'UTR luciferase reporter plasmidGLO1 3' UTR sequence
    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GLO1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GLO1
    Sirion Biotech Customized lentivirus for stable overexpression of GLO1 
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GLO1

    Additional mRNA sequence: 

    AB209801.1 AK129573.1 AK130312.1 AK293345.1 AK312662.1 AL833442.1 BC001741.1 BC011365.1 
    BC015934.1 BT019987.1 BT019988.1 D13315.1 L07837.1 S83285.1 

    24/30 DOTS entries (see all 30):

    DT.450401  DT.99971808  DT.100877401  DT.100045031  DT.100877402  DT.100877410  DT.95278177  DT.100877395 
    DT.121335170  DT.91835118  DT.121335123  DT.121335183  DT.100877396  DT.100877398  DT.100877399  DT.100877411 
    DT.121335114  DT.121335119  DT.121335134  DT.121335151  DT.121335154  DT.121335184  DT.121335187  DT.92457130 

    24/850 AceView cDNA sequences (see all 850):

    CR619737 AA424144 AI804262 BF222149 CR618038 CB143264 BQ003594 BG743167 
    AW206184 BQ045304 AU120125 BP356053 BI856342 CB159083 CR625986 H79086 
    BP371053 BM974379 BX334382 CR596001 F06249 AL534211 AI073779 CR610558 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for GLO1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d
    SP1:                    -     -                                       
    SP2:                          -                                       
    SP3:                    -     -     -     -                           
    SP4:                                                                  


    ECgene alternative splicing isoforms for GLO1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GLO1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAACCGTGC
    GLO1 Expression
    About this image


    See GLO1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GLO1

    SOURCE GeneReport for Unigene cluster: Hs.268849
        SABiosciences Expression via Pathway-Focused PCR Array including GLO1: 
              Apoptosis 384HT in human mouse rat

    Primer
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for GLO1 gene from 9/27 species (see all 27)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Glo11 , 5 glyoxalase 11, 5 82.43(n)1
    90.22(a)1
      17 (15.69 cM)5
    1098011  NM_001113560.11  NP_001107032.11 
     305928665 
    chicken
    (Gallus gallus)
    Aves GLO11 glyoxalase I 82.31(n)
    84.92(a)
      421428  XM_419481.3  XP_419481.1 
    lizard
    (Anolis carolinensis)
    Reptilia GLO16
    Uncharacterized protein
    82(a)
    1 ↔ 1
    1(230001106-230018134)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.55242 Xenopus laevis transcribed sequence with moderate similarity more 76.43(n)    48057372 
    zebrafish
    (Danio rerio)
    Actinopterygii glo12 Danio rerio cDNA clone MGC66035 IMAGE6794494, complete more 74.22(n)    BC062383.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG17071 , 3 lactoylglutathione lyase3
    CG17071
    69(a)3
    60.82(n)1
    69.01(a)1
      43B23
    356561  NM_136426.21  NP_610270.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GLO1(YML004C)4
    GLO11
    Monomeric glyoxalase I, catalyzes the detoxification more4
    Glo1p1
    56.18(n)1
    49.65(a)1
      13(262685-261705)4
    8550091, 4  NP_013710.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G081101 lactoylglutathione lyase 61.52(n)
    61.73(a)
      837330  NM_001035919.2  NP_001030996.1 
    rice
    (Oryza sativa)
    Liliopsida Os.110102 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 73.82(n)    AK070232.1 


    ENSEMBL Gene Tree for GLO1 (if available)
    TreeFam Gene Tree for GLO1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: LGUL_HUMAN, Q04760
    Polymorphism: Exists in three separable isoforms which originate from two alleles in the genome. These correspond
    to two homodimers and one heterodimer composed of two subunits showing different electrophoretic properties


    10/630 SNPs in GLO1 are shown (see all 630)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs47461,2,4
    C,F,Hunknown138561547(-) TGATGA/CGACCC 2 E A mis123Minor allele frequency- N:0.00EA NA NS WA CSA EU 7549
    rs122125111,2
    C,F--38363945(+) AGGGAG/AAGAGA 1 -- int1 trp33Minor allele frequency- A:0.50NA WA 6
    rs1397323001,2
    C--38363951(+) GAGAG-/GAAGGAA
    GGAAGGAAA
    GAAGG
    1 -- int10--------
    rs38395371,2
    C--38364455(+) TTTCT-/AGGTGC 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1832506991,2
    --38389318(+) TCTTTC/TTTTTT 1 -- us2k10--------
    rs1466466821,2
    --38554132(+) ATAAAA/CCAGTG 1 -- ds50010--------
    rs734143701,2
    C--38554208(+) TTAAAG/TAATGA 1 -- ds50011Minor allele frequency- T:0.50WA 2
    rs1414467891,2
    --38554241(+) TTTTAC/TTCAGC 1 -- ds50010--------
    rs1842542861,2
    --38554331(+) TTCTAG/TCACTC 1 -- ds50010--------
    rs792997691,2
    C,F--38554355(+) GGTCTT/CCATAA 1 -- ds50011Minor allele frequency- C:0.17EA 120

    HapMap Linkage Disequilibrium report for GLO1 (38643701 - 38670952 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for GLO1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv507326CNV Insertion20534489
    nsv885817CNV Loss21882294
    nsv830642CNV Loss17160897
    nsv428144CNV Gain18775914
    dgv1942e1CNV Complex17122850


    Human Gene Mutation Database (HGMD): GLO1
    SABiosciences Cancer Mutation PCR Assays
    1 SABiosciences qBiomarker Copy Number PCR Array containing GLO1:
    Gastric Cancer
    SeqTarget long-range PCR primers for resequencing GLO1
    DNA2.0 Custom Variant and Variant Library Synthesis for GLO1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 138750    OMIM disorders: --

    20/48 diseases for GLO1 (see all 48):    About MalaCards
    paracoccidioidomycosis    hyperglycemia    uremia    autistic disorder
    brain cancer    pulmonary tuberculosis    brain disease    open-angle glaucoma
    primary open angle glaucoma    familial mediterranean fever    panic disorder    fibrosarcoma
    endocarditis    spinocerebellar ataxia    leishmaniasis    glaucoma
    mood disorder    oligodendroglioma    autism spectrum disorder    nephrotic syndrome


    GLO1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/27 Novoseek inferred disease relationships for GLO1 gene (see all 27)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    uremia 26.3 1 14641060 (1)
    spinocerebellar ataxias 25.4 2 1675045 (2)
    hyperglycemia 16.5 1 18227068 (1)
    leukemia 14.6 8 10807791 (2), 19920924 (1), 11489834 (1), 1472100 (1)
    cancer 4.59 10 20093988 (2), 1459997 (1), 11788994 (1), 14641067 (1) (see all 8)
    leishmaniasis 3.66 2 16511153 (1)
    tuberculosis pulmonary 3.47 3 12942785 (1), 10765730 (1), 11785295 (1)
    niddm 3.39 1 19412133 (1)
    alzheimers disease 1.88 3 15128939 (2), 18455873 (1)
    brain diseases 1.49 1 15128939 (1)

    Genatlas disease: GLO1
    glyoxalase I deficiency

    Genetic Association Database (GAD): GLO1
    Human Genome Epidemiology (HuGE) Navigator: GLO1 (24 documents)

    Export disorders for GLO1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GLO1 gene, integrated from 9 sources (see all 310):
    (articles sorted by number of sources associating them with GLO1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human glyoxalase I. cDNA cloning, expression, and sequence similarity to glyoxalase I from Pseudomonas putida. (PubMed id 7684374)1, 2, 3, 9 Kim N.-S.... Kato S. (1993)
    2. Cloning and characterization of human colon glyoxalase-I. (PubMed id 8449929)1, 2, 3, 9 Ranganathan S.... Tew K.D. (1993)
    3. Distribution of glyoxalase I polymorphism among Zuni Indians: the Zuni Kidney Project. (PubMed id 18413187)1, 4, 9 Degaffe G.H....Shah V.O. (2008)
    4. Lack of evidence to support the glyoxalase 1 gene (GLO1) as a risk gene of autism in Han Chinese patients from Taiwan. (PubMed id 18721844)1, 4, 9 Wu Y.Y....Chen C.H. (2008)
    5. Posttranslational modification of human glyoxalase 1 indicates redox-dependent regulation. (PubMed id 20454679)1, 2, 9 Birkenmeier G....Birkemeyer C. (2010)
    6. CYP17, GSTP1, PON1 and GLO1 gene polymorphisms as risk factors for breast cancer: an Italian case-control study. (PubMed id 19379515)1, 4, 9 Antognelli C....Rulli A. (2009)
    7. No association between common variants in glyoxalase 1 and autism spectrum disorders. (PubMed id 17722011)1, 4, 9 Rehnstrom K....Hovatta I. (2008)
    8. Case-control and family-based association studies of candidate genes in autistic disorder and its endophenotypes: TPH2 and GLO1. (PubMed id 17346350)1, 4, 9 Sacco R....Persico A.M. (2007)
    9. Polymorphisms in glyoxalase 1 gene are not associated with vascular complications: the Hoorn and CoDAM studies. (PubMed id 19412133)1, 4, 9 Engelen L....Schalkwijk C.G. (2009)
    10. Genomic sequence of human glyoxalase-I: analysis of promoter activity and its regulation. (PubMed id 10564821)1, 2, 9 Ranganathan S.... Tew K.D. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2739 HGNC: 4323 AceView: GLO1 Ensembl:ENSG00000124767 euGenes: HUgn2739
    ECgene: GLO1 Kegg: 2739 H-InvDB: GLO1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GLO1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GLO1 gene:
    Search GeneIP for patents involving GLO1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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