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GLO1 Gene

protein-coding   GIFtS: 70
GCID: GC06M038643

Glyoxalase I

  Search for GLO1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Glyoxalase I1 2 3     HEL-S-742
Glyoxalase Domain Containing 11 2     aldoketomutase2
Glx I2 3     Epididymis Secretory Protein Li 742
Ketone-Aldehyde Mutase2 3     Lactoyl Glutathione Lyase2
S-D-Lactoylglutathione Methylglyoxal Lyase2 3     Lactoylglutathione Lyase2
EC 4.4.1.53 8     methylglyoxalase2
GLOD12     Aldoketomutase3
GLYI2     Methylglyoxalase3

External Ids:    HGNC: 43231   Entrez Gene: 27392   Ensembl: ENSG000001247677   OMIM: 1387505   UniProtKB: Q047603   

Export aliases for GLO1 gene to outside databases

Previous GC identifers: GC06M038645 GC06M038690 GC06M038751 GC06M038361


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GLO1 Gene:
The enzyme encoded by this gene is responsible for the catalysis and formation of S-lactoyl-glutathione from
methylglyoxal condensation and reduced glutatione. Glyoxalase I is linked to HLA and is localized to
6p21.3-p21.1, between HLA and the centromere. (provided by RefSeq, Jul 2008)

GeneCards Summary for GLO1 Gene:
GLO1 (glyoxalase I) is a protein-coding gene. GO annotations related to this gene include lactoylglutathione lyase activity.

UniProtKB/Swiss-Prot: LGUL_HUMAN, Q04760
Function: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to
S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B. Required
for normal osteoclastogenesis

Gene Wiki entry for GLO1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the GLO1 gene promoter:
         GR   STAT1   p53   HNF-3beta   C/EBPalpha   AREB6   Ik-2   FOXO4   STAT3   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGLO1 promoter sequence
   Search Chromatin IP Primers for GLO1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GLO1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3-p21.1   Ensembl cytogenetic band:  6p21.2   HGNC cytogenetic band: 6p21.3-p21.1

GLO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GLO1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M038643:  view genomic region     (about GC identifiers)

Start:
38,643,701 bp from pter      End:
38,670,952 bp from pter
Size:
27,252 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: LGUL_HUMAN, Q04760 (See protein sequence)
Recommended Name: Lactoylglutathione lyase  
Size: 184 amino acids; 20778 Da
Cofactor: Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits
Subunit: Homodimer
Mass spectrometry: Mass=20687.4; Method=Electrospray; Range=2-184 (Q04760-1); Note=Variant Glu-111;
Source=PubMed:20454679;
Mass spectrometry: Mass=20629.7; Method=Electrospray; Range=2-184 (Q04760-1); Note=Variant Ala-111;
Source=PubMed:20454679;
Sequence caution: Sequence=BAD93038.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Selected PDB 3D structures from and Proteopedia for GLO1 (see all 7):
1BH5 (3D)        1FRO (3D)        1QIN (3D)        1QIP (3D)        3VW9 (3D)        3W0T (3D)    
Secondary accessions: B2R6P7 B4DDV0 P78375 Q59EL0 Q5TZW3 Q96FC0 Q96J41
Alternative splicing: 2 isoforms:  Q04760-1   Q04760-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for GLO1: NX_Q04760

Explore proteomics data for GLO1 at MOPED

Post-translational modifications: 

  • Glutathionylation at Cys-139 inhibits enzyme activity1
  • Phosphorylated at Thr-107 in the presence of CaMK2. However, this is a consensus site for phosphorylation by CK2
    so phosphorylation may be mediated by CK2 rather than CaMK2. Phosphorylation is induced by TNF and suppresses the
    TNF-induced transcriptional activity of NF-kappa-B1
  • Exists in a nitric oxide (NO)-modified form. The exact nature of the modification is unknown, but it suppresses
    the TNF-induced transcriptional activity of NF-kappa-B1
  • Ubiquitination2 at Lys44, Lys140, Lys148
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for GLO1 (Q04760) (see all 7)
     PDGYWIE  RFEELGV  ELTHNWGT  KSLDFYTRVLG 


    See GLO1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006699.2  
    ENSEMBL proteins: 
     ENSP00000362463  

    GLO1 Human Recombinant Protein Products:

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    R&D Systems Recombinant & Natural Proteins for GLO1 (Glyoxalase I)
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    Novus Biologicals GLO1 Proteins
    Novus Biologicals GLO1 Lysate
    Sino Biological Recombinant Protein for GLO1
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for GLO1

     
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    GLO1 Antibody Products:

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    ThermoFisher Antibody for GLO1
    LSBio Antibodies in human, mouse, rat for GLO1

    GLO1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Search eBioscience for ELISAs for GLO1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR018146 Glyoxalase_1_CS
     IPR004361 Glyoxalase_1
     IPR004360 Glyas_Fos-R_dOase_dom

    Graphical View of Domain Structure for InterPro Entry Q04760

    ProtoNet protein and cluster: Q04760

    3 Blocks protein domains:
    IPB004360 Glyoxalase/Bleomycin resistance protein/dioxygenase domain
    IPB004361 Glyoxalase I
    IPB011588 Glyoxalase/extradiol ring-cleavage dioxygenase


    UniProtKB/Swiss-Prot: LGUL_HUMAN, Q04760
    Similarity: Belongs to the glyoxalase I family


    Find genes that share domains with GLO1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LGUL_HUMAN, Q04760
    Function: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to
    S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B. Required
    for normal osteoclastogenesis
    Catalytic activity: (R)-S-lactoylglutathione = glutathione + methylglyoxal
    Enzyme regulation: Regulated by oxidation of Cys-139 in response to the redox state of the cell. Results in the
    alternative formation of cystine or glutathione-bound cysteine, the latter modification leading to reduced enzyme
    activity
    Biophysicochemical properties: Kinetic parameters: KM=1.3 mM for methylglyoxal/glutathione (native form); KM=0.7
    mM for methylglyoxal/glutathione (reduced form); Vmax=0.335 umol/min/mg enzyme with methylglyoxal/glutathione as
    substrate (native form); Vmax=0.7 umol/min/mg enzyme with methylglyoxal/glutathione as substrate (reduced form);
    Note=Reduction of GLO1 was carried out by incubation with 20 mM betamercaptoethanol prior to kinetic analysis;

         Genatlas biochemistry entry for GLO1:
    glyoxalase I

         Enzyme Number (IUBMB): EC 4.4.1.51 2

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004462lactoylglutathione lyase activity IDA11489834
    GO:0008270zinc ion binding IDA9705294
    GO:0046872metal ion binding ----
         
    Find genes that share ontologies with GLO1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for GLO1:
     Decreased POU5F1-GFP protein e  Increased HPV18 LCR reporter a 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GLO1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GLO1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GLO1

    miRNA
    Products:
        
    miRTarBase miRNAs that target GLO1:
    hsa-let-7b-5p (MIRT032365), hsa-mir-183-5p (MIRT047098), hsa-mir-92a-3p (MIRT049258), hsa-mir-17-5p (MIRT050980), hsa-mir-222-3p (MIRT046725), hsa-mir-7-5p (MIRT025781), hsa-mir-193b-3p (MIRT016416)

    Block miRNA regulation of human, mouse, rat GLO1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GLO1 (see all 10):
    hsa-miR-4303 hsa-miR-576-5p hsa-miR-944 hsa-miR-3179 hsa-miR-146a* hsa-miR-302f hsa-miR-4310 hsa-miR-205*
    SwitchGear 3'UTR luciferase reporter plasmidGLO1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for GLO1
    Predesigned siRNA for gene silencing in human, mouse, rat GLO1

    Gene Editing
    Products:
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    Clone
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    OriGene ORF clones in mouse, rat for GLO1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GLO1 (NM_006708)
    Sino Biological Human cDNA Clone for GLO1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GLO1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GLO1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for GLO1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GLO1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus4
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm TAS16130169
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with GLO1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GLO1 About    
    See pathways by source

    SuperPathContained pathways About
    1Pyruvate metabolism
    methylglyoxal degradation I0.00
    Pyruvate metabolism


    Find genes that share SuperPaths with GLO1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for GLO1
        methylglyoxal degradation I



    1 Kegg Pathway  (Kegg details for GLO1):
        Pyruvate metabolism

    UniProtKB/Swiss-Prot: LGUL_HUMAN, Q04760
    Pathway: Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2

        Pathway & Disease-focused RT2 Profiler PCR Array including GLO1: 

              Apoptosis 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for GLO1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GLO1 (Q047603 ENSP000003624634) via UniProtKB, MINT, STRING, and/or I2D (see all 67)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP1LC3BQ9GZQ83, ENSP000002686074I2D: score=1 STRING: ENSP00000268607
    IKBKEQ141643, ENSP000003560874I2D: score=1 STRING: ENSP00000356087
    ATG16L1Q676U53I2D: score=1 
    ATG5Q9H1Y03I2D: score=1 
    CAMKK2Q96RR43I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006749glutathione metabolic process IEA--
    GO:0009438methylglyoxal metabolic process IEA--
    GO:0030316osteoclast differentiation ISS--

    Find genes that share ontologies with GLO1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GLO1 (LGUL)

    3 HMDB Compounds for GLO1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 32)70-18-8--
    Pyruvaldehyde1,2-Propanedione (see all 16)78-98-8--
    S-Lactoylglutathione(R)-S-lactoylglutathione (see all 13)25138-66-3--

    8 DrugBank Compounds for GLO1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Beta-Mercaptoethanol-- 60-24-2target--17139284 17016423
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 5)70-18-8target--17664277 17609286
    S-(N-Hydroxy-N-Iodophenylcarbamoyl)Glutathione-- --target--17139284 17016423
    S-Benzyl-Glutathione-- --target--17139284 17016423
    S-Hexylglutathione-- --target--17139284 17016423
    S-P-Nitrobenzyloxycarbonylglutathione-- --target--17139284 17016423
    IndomethacinIMN (see all 9)53-86-1targetinhibitor17243824
    methyl 4-(2,3-dihydroxy-5-methylphenoxy)-2-hydroxy-6-methylbenzoate-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for GLO1 gene (see all 55)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    methylglyoxal 95.3 111 20204770 (4), 7859825 (3), 20093988 (3), 8636255 (2) (see all 64)
    s-d-lactoylglutathione 94.9 14 11459475 (1), 18448828 (1), 19062100 (1), 17110973 (1) (see all 12)
    s-(p-bromobenzyl)glutathione 94.1 7 10206549 (1), 8304987 (1), 8787553 (1), 8489699 (1) (see all 6)
    2-crotonyloxymethyl-2-cyclohexenone 89.5 4 11975603 (1), 11922820 (1)
    s-p-nitrobenzoxycarbonylglutathione 86.3 2 1472100 (1), 8489699 (1)
    tlk 199 79.2 1 7619046 (1)
    s-hexylglutathione 75.3 3 9359858 (1), 8489699 (1)
    glyoxal 73.9 7 14641060 (2), 16037241 (2), 16427160 (1), 20102351 (1) (see all 5)
    cotc 73.7 3 15686923 (2), 11922820 (1)
    6-phosphogluconate 65.3 9 2129617 (1), 12503751 (1), 1532788 (1), 1493913 (1) (see all 7)



    Find genes that share compounds with GLO1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GLO1 gene: 
    NM_006708.2  

    Unigene Cluster for GLO1:

    Glyoxalase I
    Hs.268849  [show with all ESTs]
    Unigene Representative Sequence: NM_006708
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373365(uc003ooc.3) ENST00000470973
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate GLO1 (see all 10):
    hsa-miR-4303 hsa-miR-576-5p hsa-miR-944 hsa-miR-3179 hsa-miR-146a* hsa-miR-302f hsa-miR-4310 hsa-miR-205*
    SwitchGear 3'UTR luciferase reporter plasmidGLO1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat GLO1
    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GLO1
    Primer
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    OriGene qPCR primer pairs and template standards for GLO1
    OriGene qSTAR qPCR primer pairs in human, mouse for GLO1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GLO1
      QuantiTect SYBR Green Assays in human, mouse, rat GLO1
      QuantiFast Probe-based Assays in human, mouse, rat GLO1

    Additional mRNA sequence: 

    AB209801.1 AK129573.1 AK130312.1 AK293345.1 AK312662.1 AL833442.1 BC001741.1 BC011365.1 
    BC015934.1 BT019987.1 BT019988.1 D13315.1 L07837.1 S83285.1 

    Selected DOTS entries (see all 30):

    DT.450401  DT.99971808  DT.100877401  DT.100045031  DT.100877402  DT.100877410  DT.95278177  DT.100877395 
    DT.121335170  DT.91835118  DT.121335123  DT.121335183  DT.100877396  DT.100877398  DT.100877399  DT.100877411 
    DT.121335114  DT.121335119  DT.121335134  DT.121335151  DT.121335154  DT.121335184  DT.121335187  DT.92457130 

    Selected AceView cDNA sequences (see all 850):

    AI073779 CD679207 BM664170 CN482505 BI861609 BQ231429 AA131809 CB157295 
    CR619737 CR618038 CB850996 BM541318 AI804262 AI752986 BM458127 BC015934 
    CB143264 BQ438305 AI685559 BU621307 AL534211 AI088646 AI638517 CA444943 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for GLO1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d
    SP1:                    -     -                                       
    SP2:                          -                                       
    SP3:                    -     -     -     -                           
    SP4:                                                                  


    ECgene alternative splicing isoforms for GLO1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    GLO1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAACCGTGC
    GLO1 Expression
    About this image


    GLO1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    GLO1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GLO1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.268849
        Pathway & Disease-focused RT2 Profiler PCR Array including GLO1: 
              Apoptosis 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for GLO1 gene from Selected species (see all 27)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Glo11 , 5 glyoxalase 11, 5 82.43(n)1
    90.22(a)1
      17 (15.69 cM)5
    1098011  NM_025374.31  NP_079650.31 
     305928665 
    chicken
    (Gallus gallus)
    Aves GLO11 glyoxalase I 82.31(n)
    84.92(a)
      421428  XM_419481.4  XP_419481.1 
    lizard
    (Anolis carolinensis)
    Reptilia GLO16
    glyoxalase I
    84(a)
    1 ↔ 1
    1(230001106-230018134)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.55242 Xenopus laevis transcribed sequence with moderate similarity more 76.43(n)    48057372 
    zebrafish
    (Danio rerio)
    Actinopterygii glo12 Danio rerio cDNA clone MGC66035 IMAGE6794494, complete more 74.22(n)    BC062383.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG17071 , 3 lactoylglutathione lyase3
    CG17071
    69(a)3
    60.82(n)1
    69.01(a)1
      43B23
    356561  NM_136426.31  NP_610270.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GLO1(YML004C)4
    GLO11
    Monomeric glyoxalase I, catalyzes the detoxification more4
    GLO11
    56.25(n)1
    49.31(a)1
      13(262685-261705)4
    8550091, 4  NP_013710.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G081101 AT1G08110 61.18(n)
    60.98(a)
      837330  NM_001035918.1  NP_001030995.1 
    rice
    (Oryza sativa)
    Liliopsida Os.110102 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 73.82(n)    AK070232.1 


    ENSEMBL Gene Tree for GLO1 (if available)
    TreeFam Gene Tree for GLO1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    LGUL_HUMAN, Q04760: Exists in three separable isoforms which originate from two alleles in the genome. These correspond
    to two homodimers and one heterodimer composed of two subunits showing different electrophoretic properties


    Selected SNPs for GLO1 (see all 630)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs47461,2,,4
    C,F,Hunknown138561547(-) TGATGA/CGACCC 2 E A mis123Minor allele frequency- N:0.00EA NA NS WA CSA EU 7549
    rs122125111,2
    C,F--38363945(+) AGGGAG/AAGAGA 1 -- int1 trp33Minor allele frequency- A:0.50NA WA 6
    rs1397323001,2
    C--38363951(+) GAGAG-/GAAGGAA
    GGAAGGAAA
    GAAGG
    1 -- int10--------
    rs38395371,2
    C--38364455(+) TTTCT-/AGGTGC 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1832506991,2
    --38389318(+) TCTTTC/TTTTTT 1 -- us2k10--------
    rs1466466821,2
    --38554132(+) ATAAAA/CCAGTG 1 -- ds50010--------
    rs734143701,2
    C--38554208(+) TTAAAG/TAATGA 1 -- ds50011Minor allele frequency- T:0.50WA 2
    rs1414467891,2
    --38554241(+) TTTTAC/TTCAGC 1 -- ds50010--------
    rs1842542861,2
    --38554331(+) TTCTAG/TCACTC 1 -- ds50010--------
    rs792997691,2
    C,F--38554355(+) GGTCTT/CCATAA 1 -- ds50011Minor allele frequency- C:0.17EA 120

    HapMap Linkage Disequilibrium report for GLO1 (38643701 - 38670952 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for GLO1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv507326CNV Insertion20534489
    nsv885817CNV Loss21882294
    nsv830642CNV Loss17160897
    nsv428144CNV Gain18775914
    dgv1942e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): GLO1
    Site Specific Mutation Identification with PCR Assays
    1 Copy Number PCR Panel containing GLO1:
    Gastric Cancer
    SeqTarget long-range PCR primers for resequencing GLO1
    DNA2.0 Custom Variant and Variant Library Synthesis for GLO1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 138750    OMIM disorders: --


    Find genes that share disorders with GLO1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for GLO1 gene (see all 27)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    uremia 26.3 1 14641060 (1)
    spinocerebellar ataxias 25.4 2 1675045 (2)
    hyperglycemia 16.5 1 18227068 (1)
    leukemia 14.6 8 10807791 (2), 19920924 (1), 11489834 (1), 1472100 (1)
    cancer 4.59 10 20093988 (2), 1459997 (1), 11788994 (1), 14641067 (1) (see all 8)
    leishmaniasis 3.66 2 16511153 (1)
    tuberculosis pulmonary 3.47 3 12942785 (1), 10765730 (1), 11785295 (1)
    niddm 3.39 1 19412133 (1)
    alzheimers disease 1.88 3 15128939 (2), 18455873 (1)
    brain diseases 1.49 1 15128939 (1)

    Genatlas disease: GLO1
    glyoxalase I deficiency

    Genetic Association Database (GAD): GLO1
    Human Genome Epidemiology (HuGE) Navigator: GLO1 (24 documents)

    Export disorders for GLO1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GLO1 gene, integrated from 10 sources (see all 316):
    (articles sorted by number of sources associating them with GLO1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human glyoxalase I. cDNA cloning, expression, and sequence similarity to glyoxalase I from Pseudomonas putida. (PubMed id 7684374)1, 2, 3, 9 Kim N.-S.... Kato S. (J. Biol. Chem. 1993)
    2. Cloning and characterization of human colon glyoxalase-I. (PubMed id 8449929)1, 2, 3, 9 Ranganathan S.... Tew K.D. (J. Biol. Chem. 1993)
    3. Distribution of glyoxalase I polymorphism among Zuni Indians: the Zuni Kidney Project. (PubMed id 18413187)1, 4, 9 Degaffe G.H....Shah V.O. (J. Diabetes Complicat. 2008)
    4. Lack of evidence to support the glyoxalase 1 gene (GLO1) as a risk gene of autism in Han Chinese patients from Taiwan. (PubMed id 18721844)1, 4, 9 Wu Y.Y....Chen C.H. (amp 2008)
    5. Posttranslational modification of human glyoxalase 1 indicates redox- dependent regulation. (PubMed id 20454679)1, 2, 9 Birkenmeier G....Birkemeyer C. (PLoS ONE 2010)
    6. CYP17, GSTP1, PON1 and GLO1 gene polymorphisms as risk factors for breast cancer: an Italian case-control study. (PubMed id 19379515)1, 4, 9 Antognelli C....Rulli A. (BMC Cancer 2009)
    7. No association between common variants in glyoxalase 1 and autism spectrum disorders. (PubMed id 17722011)1, 4, 9 RehnstrAPm K....Hovatta I. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008)
    8. Case-control and family-based association studies of candidate genes in autistic disorder and its endophenotypes: TPH2 and GLO1. (PubMed id 17346350)1, 4, 9 Sacco R....Persico A.M. (BMC Med. Genet. 2007)
    9. Polymorphisms in glyoxalase 1 gene are not associated with vascular complications: the Hoorn and CoDAM studies. (PubMed id 19412133)1, 4, 9 Engelen L....Schalkwijk C.G. (J. Hypertens. 2009)
    10. Genomic sequence of human glyoxalase-I: analysis of promoter activity and its regulation. (PubMed id 10564821)1, 2, 9 Ranganathan S.... Tew K.D. (Gene 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2739 HGNC: 4323 AceView: GLO1 Ensembl:ENSG00000124767 euGenes: HUgn2739
    ECgene: GLO1 Kegg: 2739 H-InvDB: GLO1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GLO1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GLO1 gene:
    Search GeneIP for patents involving GLO1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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