GLO1 Gene
protein-coding GIFtS: 68
GCID: GC06M038690
|
|
glyoxalase I
| |
Aliases
for GLO1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Glyoxalase I1 2 3 | | Aldoketomutase3 | | GLOD11 2 | | Glyoxalase Domain Containing 12 | | Glx I2 3 | | Lactoyl Glutathione Lyase2 | | Ketone-Aldehyde Mutase2 3 | | Lactoylglutathione Lyase2 | | S-D-Lactoylglutathione Methylglyoxal Lyase2 3 | | Methylglyoxalase3 | | EC 4.4.1.53 8 | | Aldoketomutase3 | | GLYI2 | | Methylglyoxalase3 |
Export aliases for GLO1 gene to outside databasesPrevious GC identifers: GC06M038645 GC06M038751 GC06M038361 |
Summaries
for GLO1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for GLO1:
The enzyme encoded by this gene is responsible for the catalysis and formation of S-lactoyl-glutathione frommethylglyoxal condensation and reduced glutatione. Glyoxalase I is linked to HLA and is localized to 6p21.3-p21.1,between HLA and the centromere. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: LGUL_HUMAN, Q04760Function: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, toS-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B
Gene Wiki entry for GLO1
|
Genomic Views
for GLO1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the GLO1 gene promoter:
GR STAT1 p53 HNF-3beta C/EBPalpha AREB6 Ik-2 FOXO4 STAT3 GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for GLO1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GLO1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21.3-p21.1 Ensembl cytogenetic band: 6p21.2 HGNC cytogenetic band: 6p21.3-p21.1GLO1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M038690: view genomic region
(about GC identifiers)
Start:
|
38,643,701 bp from pter |
End:
|
38,670,952 bp from pter |
Size:
|
27,252 bases |
Orientation:
|
minus strand |
|
Proteins
for GLO1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: LGUL_HUMAN, Q04760 (See
protein sequence)Recommended Name: Lactoylglutathione lyase Size: 184 amino acids; 20778 Da
Cofactor: Binds 1 zinc ion per subunit
Subunit: Homodimer
Mass spectrometry: Mass=20687.4; Method=Electrospray; Range=2-184 (Q04760-1); Note=Variant Glu-111;Source=PubMed:20454679;
Mass spectrometry: Mass=20629.7; Method=Electrospray; Range=2-184 (Q04760-1); Note=Variant Ala-111;Source=PubMed:20454679;
Sequence caution: Sequence=BAD93038.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
5 PDB 3D structures from  and Proteopedia  for GLO1:1BH5 (3D)
1FRO (3D)
1QIN (3D)
1QIP (3D)
3VW9 (3D)
Secondary accessions: B2R6P7 B4DDV0 P78375 Q59EL0 Q5TZW3 Q96FC0 Q96J41Alternative splicing: 2 isoforms: Q04760-1 Q04760-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for GLO1: NX_Q04760
Post-translational modifications:
Glutathionylation at Cys-139 inhibits enzyme activity1
Phosphorylated at Thr-107 in the presence of CaMK2. However, this is a consensus site for phosphorylation by CK2 sophosphorylation may be mediated by CK2 rather than CaMK2. Phosphorylation is induced by TNF and suppresses theTNF-induced transcriptional activity of NF-kappa-B1
Exists in a nitric oxide (NO)-modified form. The exact nature of the modification is unknown, but it suppresses theTNF-induced transcriptional activity of NF-kappa-B1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q04760
4/7 DME Specific Peptides for GLO1 (Q04760) (see all 7)
GLO1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_006699.2
ENSEMBL proteins: ENSP00000362463
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
GLO1 for ontologies About GeneDecksing
GLO1 Antibody Products:
Assay Products for GLO1: |
Protein
Domains /
Families
for GLO1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GLO1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q04760ProtoNet protein and cluster: Q04760 3 Blocks protein families: IPB004360 Glyoxalase/Bleomycin resistance protein/dioxygenase domain IPB004361 Glyoxalase I IPB011588 Glyoxalase/extradiol ring-cleavage dioxygenase
UniProtKB/Swiss-Prot: LGUL_HUMAN, Q04760Similarity: Belongs to the glyoxalase I family |
Function
for GLO1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: LGUL_HUMAN, Q04760Function: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, toS-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-BCatalytic activity: (R)-S-lactoylglutathione = glutathione + methylglyoxalEnzyme regulation: Regulated by oxidation of Cys-139 in response to the redox state of the cell. Results in thealternative formation of cystine or glutathione-bound cysteine, the latter modification leading to reduced enzymeactivityBiophysicochemical properties: Kinetic parameters: KM=1.3 mM for methylglyoxal/glutathione (native form); KM=0.7 mM formethylglyoxal/glutathione (reduced form); Vmax=0.335 umol/min/mg enzyme with methylglyoxal/glutathione as substrate(native form); Vmax=0.7 umol/min/mg enzyme with methylglyoxal/glutathione as substrate (reduced form); Note=Reductionof GLO1 was carried out by incubation with 20 mM betamercaptoethanol prior to kinetic analysis; Genatlas biochemistry entry for GLO1:glyoxalase I
Enzyme Number (IUBMB): EC 4.4.1.51 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GLO1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GLO1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: GLO1 (NM_006708) | |  | Sino Biological Human cDNA Clone for GLO1 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GLO1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GLO1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GLO1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
GLO1 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for GLO1:
|
Pathways & Interactions
for GLO1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Pyruvate metabolism | | | 2 | methylglyoxal degradation I | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  BioSystems Pathway for GLO1
1 
Kegg Pathway (Kegg details for GLO1):
UniProtKB/Swiss-Prot: LGUL_HUMAN, Q04760Pathway: Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2
GLO1 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GLO1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 22)
5/37 Interacting proteins for GLO1 (Q047603 ENSP000003624634) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005975 | carbohydrate metabolic process |
IEA | -- | | GO:0006357 | regulation of transcription from RNA polymerase II promoter |
IEA | -- | | GO:0006749 | glutathione metabolic process |
IEA | -- | | GO:0009438 | methylglyoxal metabolic process |
IEA | -- | | GO:0043066 | negative regulation of apoptotic process |
TAS | 16130169 |
GLO1 for ontologies About GeneDecksing
|
Drugs & Compounds
for GLO1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
GLO1 for compounds About GeneDecksing
 Browse Tocris compounds for GLO1
3 HMDB Compounds for GLO1 About this table
8 DrugBank Compounds for GLO1 About this table
10/55 Novoseek chemical compound relationships for GLO1 gene (see all 55) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| methylglyoxal |
95.3 |
111 |
20204770 (4), 7859825 (3), 20093988 (3), 8636255 (2) (see all 64) |
| s-d-lactoylglutathione |
94.9 |
14 |
11459475 (1), 18448828 (1), 19062100 (1), 17110973 (1) (see all 12) |
| s-(p-bromobenzyl)glutathione |
94.1 |
7 |
10206549 (1), 8304987 (1), 8787553 (1), 8489699 (1) (see all 6) |
| 2-crotonyloxymethyl-2-cyclohexenone |
89.5 |
4 |
11975603 (1), 11922820 (1) |
| s-p-nitrobenzoxycarbonylglutathione |
86.3 |
2 |
1472100 (1), 8489699 (1) |
| tlk 199 |
79.2 |
1 |
7619046 (1) |
| s-hexylglutathione |
75.3 |
3 |
9359858 (1), 8489699 (1) |
| glyoxal |
73.9 |
7 |
14641060 (2), 16037241 (2), 16427160 (1), 20102351 (1) (see all 5) |
| cotc |
73.7 |
3 |
15686923 (2), 11922820 (1) |
| 6-phosphogluconate |
65.3 |
9 |
2129617 (1), 12503751 (1), 1532788 (1), 1493913 (1) (see all 7) |
Search CenterWatch for drugs/clinical trials and news about GLO1 / LGUL
|
Transcripts
for GLO1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for GLO1 gene: NM_006708.2 Unigene Cluster for GLO1: Glyoxalase I Hs.268849 [show with all ESTs]Unigene Representative Sequence: NM_0067082 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000470973 ENST00000373365(uc003ooc.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GLO1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GLO1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: GLO1 (NM_006708) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GLO1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GLO1 |
Additional cDNA sequence: AB209801.1 AK129573.1 AK130312.1 AK293345.1 AK312662.1 AL833442.1 BC001741.1 BC011365.1 BC015934.1 BT019987.1 BT019988.1 D13315.1 L07837.1 S83285.1 24/29 DOTS entries (see all 29): DT.450401 DT.99971808 DT.100877401 DT.100877402 DT.100045031 DT.100877410 DT.95278177 DT.121335170 DT.91835118 DT.121335123 DT.121335183 DT.100877398 DT.100877399 DT.100877411 DT.121335114 DT.121335119 DT.121335151 DT.121335154 DT.121335184 DT.121335187 DT.92457130 DT.92457137 DT.95219421 DT.100877395 24/850 AceView cDNA sequences (see all 850): BI857046 CR610558 F04246 BM856740 BP379114 CB158540 CR623176 BM721068 BU674196 BU732147 CB960086 CB120805 AI922759 BP365236 BU159734 BM798410 BQ232494 BP379332 BQ215446 BU178996 BM693989 CK906177 BE256785 BQ003594
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for GLO1 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d |
|---|
|
| SP1: | | | | | | | - | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | - | | - | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for GLO1
|
Expression
for GLO1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| GLO1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCAACCGTGC
About this image
See GLO1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GLO1
SOURCE GeneReport for Unigene cluster: Hs.268849
SABiosciences Expression via Pathway-Focused PCR Array including GLO1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GLO1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GLO1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GLO1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GLO1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GLO1 |
Orthologs
for GLO1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for GLO1 gene from 10/39 species (see all 39) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Glo11 , 5 |
glyoxalase 11, 5 |
82.43(n)1
90.22(a)1 |
|
17 (15.69 cM)5
1098011 NM_001113560.11 NP_001107032.11
305928665 |
chicken
(Gallus gallus) |
Aves |
GLO11 |
glyoxalase I |
82.31(n)
84.92(a) |
|
421428 XM_419481.3 XP_419481.1 |
lizard
(Anolis carolinensis) |
Reptilia |
GLO16 |
-- |
81(a) |
1 ↔ 1 |
1(230001100-230014912) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.55242 |
Xenopus laevis transcribed sequence with moderate similarity more |
76.43(n) |
|
48057372 |
zebrafish
(Danio rerio) |
Actinopterygii |
glo12 |
Danio rerio cDNA clone MGC66035 IMAGE6794494, complete more |
74.22(n) |
|
BC062383.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG17071 , 3 |
lactoylglutathione lyase3
CG17071 |
69(a)3
60.82(n)1
69.01(a)1 |
|
43B23
356561 NM_136426.21 NP_610270.11 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
GLO1(YML004C)4
GLO11 |
Monomeric glyoxalase I, catalyzes the detoxification more4
Glo1p1 |
56.18(n)1
49.65(a)1 |
|
13(262685-261705)4
8550091, 4 NP_013710.11, 4 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT1G081101 |
lactoylglutathione lyase |
61.52(n)
61.73(a) |
|
837330 NM_001035919.2 NP_001030996.1 |
rice
(Oryza sativa) |
Liliopsida |
Os.110102 |
Oryza sativa (japonica cultivar-group) cDNA cloneJ more |
73.82(n) |
|
AK070232.1 |
E. coli
(Escherichia coli) |
Gamma proteobacteria |
gloA6 |
glyoxalase I, Ni-dependent |
36(a) |
1 ↔ 1 |
Chromosome(1725861-1726268) |
ENSEMBL Gene Tree for GLO1 (if available)
TreeFam Gene Tree for GLO1 (if available) |
Paralogs
for GLO1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for GLO1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
UniProtKB/Swiss-Prot: LGUL_HUMAN, Q04760Polymorphism: Exists in three separable isoforms which originate from two alleles in the genome. These correspond totwo homodimers and one heterodimer composed of two subunits showing different electrophoretic properties
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for GLO1 (38643701 - 38670952 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for GLO1
1 CNV: 3608
Human Gene Mutation Database (HGMD): GLO1
| SABiosciences Cancer Mutation PCR Assays |
| 1 SABiosciences qBiomarker Copy Number PCR Array containing GLO1: |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GLO1 |
|
Disorders
/ Diseases
for GLO1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
GLO1 for disorders About GeneDecksing
OMIM gene information: 138750
OMIM disorders: --
20/49  diseases for GLO1 (see all 49): About MalaCardsopen-angle glaucoma primary open angle glaucoma familial mediterranean fever spinocerebellar ataxia
autism spectrum disorder glaucoma autistic disorder diabetes mellitus
panic disorder uremia neurodegenerative disease paracoccidioidomycosis
mood disorder brain disease leishmaniasis liver cirrhosis
fibrosarcoma nephrotic syndrome hyperglycemia alzheimer's disease
10/27 Novoseek disease relationships for GLO1 gene (see all 27) About this table
Genatlas disease: GLO1 glyoxalase I deficiency
Genetic Association Database (GAD): GLO1
Human Genome Epidemiology (HuGE) Navigator: GLO1 (24 documents)
Export disorders for GLO1 gene to outside databases
|
Publications
for GLO1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for GLO1 gene, integrated from 9 sources (see all 303):
(articles sorted by number of sources associating them with GLO1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human glyoxalase I. cDNA cloning, expression, and sequence similarity to glyoxalase I from Pseudomonas putida. (PubMed id 7684374)1, 2, 3, 9 Kim N.-S.... Kato S. (1993)
- Cloning and characterization of human colon glyoxalase-I. (PubMed id 8449929)1, 2, 3, 9 Ranganathan S.... Tew K.D. (1993)
- Posttranslational modification of human glyoxalase 1 indicates redox-dependent regulation. (PubMed id 20454679)1, 2, 9 Birkenmeier G....Birkemeyer C. (2010)
- Genomic sequence of human glyoxalase-I: analysis of promoter activity and its regulation. (PubMed id 10564821)1, 2, 9 Ranganathan S.... Tew K.D. (1999)
- Optimized heterologous expression of the human zinc enzyme glyoxalase I. (PubMed id 8670058)1, 2, 9 Ridderstroem M. and Mannervik B. (1996)
- Reaction mechanism of glyoxalase I explored by an X-ray crystallographic analysis of the human enzyme in complex with a transition state analogue. (PubMed id 10521255)1, 2, 9 Cameron A.D....Mannervik B. (1999)
- [Genetic predisposition to development of toxic liver cirrhosis caused by alcohol] (PubMed id 11436564)1, 4, 9 Spitsyn V.A....Afanas'eva I.S. (2001)
- Involvement of an active-site Zn2+ ligand in the catalytic mechanism of human glyoxalase I. (PubMed id 9705294)1, 2, 9 Ridderstroem M.... Mannervik B. (1998)
- Association analysis of the functional Ala111Glu polymorphism of the glyoxalase I gene in panic disorder. (PubMed id 16352396)1, 4, 9 Politi P....Emanuele E. (2006)
- [Genetic polymorphism of erythrocytic enzymes in Yakut populations] (PubMed id 11963573)1, 4, 9 Tarskaia L.A....Spitsin V.A. (2002)
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External Searches for GLO1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing GLO1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing GLO1 gene
(According to HUGE)
About This Section
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Specialized Databases showing GLO1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for GLO1 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for GLO1 gene:
Search GeneIP for patents involving GLO1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for GLO1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for GLO1 | | OriGene shRNA RFP for GLO1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GLO1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GLO1 | | | OriGene Protein Over-expression Lysate for GLO1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for GLO1 | | OriGene 3'-UTR Clone for GLO1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GLO1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GLO1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for GLO1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for GLO1 | | OriGene Custom Protein Services for GLO1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GLO1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GLO1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GLO1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GLO1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GLO1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GLO1 |
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| | | | Search Tocris compounds for GLO1 |
| |  |  |  |  | | | | | | Recombinant Protein for GLO1 |
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 | | | GLO1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GLO1 |
|  |  |  | | | | ThermoFisher Antibodies for GLO1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GLO1 |
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