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Aliases for GLMP Gene

Aliases for GLMP Gene

  • Glycosylated Lysosomal Membrane Protein 2 3 5
  • Kidney Lysosomal Membrane Protein 2 3
  • Lysosomal Protein NCU-G1 3 4
  • C1orf85 3 4
  • Chromosome 1 Open Reading Frame 85 2
  • Kidney Predominant Protein NCU-G1 3
  • NCU-G1 3

External Ids for GLMP Gene

Previous HGNC Symbols for GLMP Gene

  • C1orf85

Summaries for GLMP Gene

GeneCards Summary for GLMP Gene

GLMP (Glycosylated Lysosomal Membrane Protein) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and ligand-dependent nuclear receptor transcription coactivator activity.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLMP Gene

Genomics for GLMP Gene

Regulatory Elements for GLMP Gene

Enhancers for GLMP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G156281 1.8 FANTOM5 ENCODE dbSUPER 27.1 +12.4 12432 4.4 MLX CREB3L1 ZFP64 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 GLMP SMG5 SLC25A44 PAQR6 BGLAP ENSG00000252236 SEMA4A TSACC CCT3 KIAA0907
GH01G156486 2.1 FANTOM5 Ensembl ENCODE dbSUPER 19.2 -203.2 -203175 25.4 CREB3L1 MLX DMAP1 FEZF1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 ZNF263 RRNAD1 KIAA0907 LOC246784 ENSG00000271267 SSR2 GLMP MEF2D SYT11 BCAN NAXE
GH01G156262 1 ENCODE dbSUPER 37.1 +32.7 32664 1.4 PKNOX1 ZBTB21 RB1 FOSL1 ZNF316 ZNF366 SCRT2 NFE2 MAFK NFE2L2 GLMP SMG5 PAQR6 BGLAP PMF1 SEMA4A SLC25A44 ENSG00000252236 MEX3A LMNA
GH01G156243 1.5 Ensembl ENCODE dbSUPER 24.1 +49.4 49359 4.7 HDGF PKNOX1 AGO1 YY1 TCF12 GLIS2 GATA2 ZNF143 KLF7 FOS SMG5 GLMP PAQR6 BGLAP
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GLMP on UCSC Golden Path with GeneCards custom track

Promoters for GLMP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for GLMP Gene

156,290,089 bp from pter
156,295,689 bp from pter
5,601 bases
Minus strand

Genomic View for GLMP Gene

Genes around GLMP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GLMP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GLMP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLMP Gene

Proteins for GLMP Gene

  • Protein details for GLMP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Glycosylated lysosomal membrane protein
    Protein Accession:
    Secondary Accessions:
    • A6NH16
    • B4DJN4
    • Q5SZX4
    • Q6UX96
    • Q8IV07
    • Q96F65

    Protein attributes for GLMP Gene

    406 amino acids
    Molecular mass:
    43864 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH11575.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI14165.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for GLMP Gene


neXtProt entry for GLMP Gene

Post-translational modifications for GLMP Gene

  • Highly N-glycosylated.
  • Glycosylation at Asn65, isoforms=2134, isoforms=2159, isoforms=2187, and Asn230
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GLMP Gene

Domains & Families for GLMP Gene

Protein Domains for GLMP Gene


Suggested Antigen Peptide Sequences for GLMP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GLMP family.
  • Belongs to the GLMP family.
genes like me logo Genes that share domains with GLMP: view

No data available for Gene Families for GLMP Gene

Function for GLMP Gene

Molecular function for GLMP Gene

UniProtKB/Swiss-Prot Induction:
Transcription is activated by TFEB.

Gene Ontology (GO) - Molecular Function for GLMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 transcription factor activity, sequence-specific DNA binding IMP 18021396
GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding IMP 18021396
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity IDA 18021396
GO:0044212 transcription regulatory region DNA binding IDA 18021396
genes like me logo Genes that share ontologies with GLMP: view
genes like me logo Genes that share phenotypes with GLMP: view

Animal Models for GLMP Gene

MGI Knock Outs for GLMP:

Animal Model Products

miRNA for GLMP Gene

miRTarBase miRNAs that target GLMP

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GLMP Gene

Localization for GLMP Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLMP Gene

Lysosome membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GLMP gene
Compartment Confidence
cytosol 5
lysosome 5
nucleus 4
plasma membrane 3
extracellular 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GLMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 18021396
GO:0005764 lysosome IEA,IDA 19556463
GO:0005765 lysosomal membrane IEA --
GO:0005829 cytosol IDA 18021396
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with GLMP: view

Pathways & Interactions for GLMP Gene

No Data Available

Interacting Proteins for GLMP Gene

Gene Ontology (GO) - Biological Process for GLMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030522 intracellular receptor signaling pathway IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IMP 18021396
genes like me logo Genes that share ontologies with GLMP: view

No data available for Pathways by source and SIGNOR curated interactions for GLMP Gene

Drugs & Compounds for GLMP Gene

No Compound Related Data Available

Transcripts for GLMP Gene

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for GLMP Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c
SP1: - -
SP2: - - -
SP3: - -
SP4: - - - - -
SP5: - - -

Relevant External Links for GLMP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GLMP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GLMP Gene

Protein differential expression in normal tissues from HIPED for GLMP Gene

This gene is overexpressed in Amniocyte (38.3) and Liver (20.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GLMP Gene

NURSA nuclear receptor signaling pathways regulating expression of GLMP Gene:


Evidence on tissue expression from TISSUES for GLMP Gene

  • Skin(4.3)
  • Intestine(4.2)
  • Spleen(4.2)
  • Nervous system(4.2)
  • Liver(2.1)
  • Kidney(2)
genes like me logo Genes that share expression patterns with GLMP: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GLMP Gene

Orthologs for GLMP Gene

This gene was present in the common ancestor of animals.

Orthologs for GLMP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C1H1orf85 34
  • 99.26 (n)
C1orf85 35
  • 99 (a)
(Bos Taurus)
Mammalia C3H1orf85 34
  • 86.14 (n)
C1orf85 35
  • 82 (a)
(Canis familiaris)
Mammalia C7H1orf85 34
  • 84.51 (n)
C1orf85 35
  • 79 (a)
(Mus musculus)
Mammalia 0610031J06Rik 35 34
  • 81.57 (n)
Glmp 16
(Rattus norvegicus)
Mammalia RGD1303130 34
  • 81.48 (n)
(Monodelphis domestica)
Mammalia C1orf85 35
  • 53 (a)
(Ornithorhynchus anatinus)
Mammalia C1orf85 35
  • 45 (a)
(Gallus gallus)
Aves LOC777136 34
  • 56.58 (n)
C1orf85 35
  • 43 (a)
(Anolis carolinensis)
Reptilia C1orf85 35
  • 41 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia c1orf85 34
  • 53.8 (n)
(Danio rerio)
Actinopterygii zgc:92308 34
  • 47.67 (n)
C19H1orf85 35
  • 33 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004431 34
  • 42.11 (n)
Species where no ortholog for GLMP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GLMP Gene

Gene Tree for GLMP (if available)
Gene Tree for GLMP (if available)

Paralogs for GLMP Gene

No data available for Paralogs for GLMP Gene

Variants for GLMP Gene

Sequence variations from dbSNP and Humsavar for GLMP Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1001191777 -- 156,296,921(+) AACAA(A/G)GGGCA upstream-variant-2KB
rs1001550071 -- 156,292,248(+) AGAAG(A/G)CATGC intron-variant, nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs1002147218 -- 156,292,524(+) ACCTC(C/T)CAGCT intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1003205872 -- 156,293,445(+) GAGTA(G/T)GCTAA intron-variant, upstream-variant-2KB, reference, synonymous-codon
rs1003646472 -- 156,293,705(+) CAATC(C/G)CTCCT intron-variant, nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for GLMP Gene

Variant ID Type Subtype PubMed ID
nsv509524 CNV insertion 20534489
nsv547968 CNV loss 21841781

Variation tolerance for GLMP Gene

Residual Variation Intolerance Score: 76.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.78; 93.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GLMP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLMP Gene

Disorders for GLMP Gene

Relevant External Links for GLMP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GLMP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GLMP Gene

Publications for GLMP Gene

  1. NCU-G1 is a highly glycosylated integral membrane protein of the lysosome. (PMID: 19489740) Schieweck O. … LA1bke T. (Biochem. J. 2009) 2 3 22 64
  2. Human NCU-G1 can function as a transcription factor and as a nuclear receptor co-activator. (PMID: 18021396) Steffensen K.R. … Eskild W. (BMC Mol. Biol. 2007) 2 3 4 64
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 64
  4. A gene network regulating lysosomal biogenesis and function. (PMID: 19556463) Sardiello M. … Ballabio A. (Science 2009) 3 4 64
  5. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4 64

Products for GLMP Gene

Sources for GLMP Gene

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