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Aliases for GLMP Gene

Aliases for GLMP Gene

  • Glycosylated Lysosomal Membrane Protein 2 3 5
  • Kidney Lysosomal Membrane Protein 2 3
  • Lysosomal Protein NCU-G1 3 4
  • C1orf85 3 4
  • Chromosome 1 Open Reading Frame 85 2
  • Kidney Predominant Protein NCU-G1 3
  • NCU-G1 3

External Ids for GLMP Gene

Previous HGNC Symbols for GLMP Gene

  • C1orf85

Summaries for GLMP Gene

GeneCards Summary for GLMP Gene

GLMP (Glycosylated Lysosomal Membrane Protein) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and ligand-dependent nuclear receptor transcription coactivator activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLMP Gene

Genomics for GLMP Gene

Regulatory Elements for GLMP Gene

Enhancers for GLMP Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GLMP on UCSC Golden Path with GeneCards custom track

Promoters for GLMP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GLMP on UCSC Golden Path with GeneCards custom track

Genomic Location for GLMP Gene

Chromosome:
1
Start:
156,290,089 bp from pter
End:
156,295,689 bp from pter
Size:
5,601 bases
Orientation:
Minus strand

Genomic View for GLMP Gene

Genes around GLMP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GLMP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GLMP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLMP Gene

Proteins for GLMP Gene

  • Protein details for GLMP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWB7-GLMP_HUMAN
    Recommended name:
    Glycosylated lysosomal membrane protein
    Protein Accession:
    Q8WWB7
    Secondary Accessions:
    • A6NH16
    • B4DJN4
    • Q5SZX4
    • Q6UX96
    • Q8IV07
    • Q96F65

    Protein attributes for GLMP Gene

    Size:
    406 amino acids
    Molecular mass:
    43864 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH11575.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI14165.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for GLMP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GLMP Gene

Proteomics data for GLMP Gene at MOPED

Post-translational modifications for GLMP Gene

  • Highly N-glycosylated.
  • Glycosylation at Asn 65, Asn 134, Asn 159, Asn 187, and Asn 230
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GLMP Gene

Domains & Families for GLMP Gene

Protein Domains for GLMP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GLMP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WWB7

UniProtKB/Swiss-Prot:

GLMP_HUMAN :
  • Belongs to the GLMP family.
Family:
  • Belongs to the GLMP family.
genes like me logo Genes that share domains with GLMP: view

No data available for Gene Families for GLMP Gene

Function for GLMP Gene

Molecular function for GLMP Gene

UniProtKB/Swiss-Prot Induction:
Transcription is activated by TFEB.

Gene Ontology (GO) - Molecular Function for GLMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044212 transcription regulatory region DNA binding IDA 18021396
genes like me logo Genes that share ontologies with GLMP: view
genes like me logo Genes that share phenotypes with GLMP: view

Animal Model Products

miRNA for GLMP Gene

miRTarBase miRNAs that target GLMP

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GLMP Gene

Localization for GLMP Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLMP Gene

Lysosome membrane; Single-pass type I membrane protein.

Gene Ontology (GO) - Cellular Components for GLMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA 18021396
genes like me logo Genes that share ontologies with GLMP: view

No data available for Subcellular locations from COMPARTMENTS for GLMP Gene

Pathways & Interactions for GLMP Gene

SuperPathways for GLMP Gene

No Data Available

Interacting Proteins for GLMP Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000354553%0d%0a9606.ENSP00000264951%0d%0a
Selected Interacting proteins: ENSP00000354553 Q8WWB7-GLMP_HUMAN for GLMP Gene via STRING I2D

Gene Ontology (GO) - Biological Process for GLMP Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GLMP Gene

Drugs & Compounds for GLMP Gene

No Compound Related Data Available

Transcripts for GLMP Gene

Alternative Splicing Database (ASD) splice patterns (SP) for GLMP Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c
SP1: - -
SP2: - - -
SP3: - -
SP4: - - - - -
SP5: - - -
SP6:

Relevant External Links for GLMP Gene

GeneLoc Exon Structure for
GLMP
ECgene alternative splicing isoforms for
GLMP

Expression for GLMP Gene

mRNA expression in normal human tissues for GLMP Gene

Protein differential expression in normal tissues from HIPED for GLMP Gene

This gene is overexpressed in Amniocyte (38.3) and Liver (20.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GLMP Gene



genes like me logo Genes that share expression patterns with GLMP: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for GLMP Gene

Orthologs for GLMP Gene

This gene was present in the common ancestor of animals.

Orthologs for GLMP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C3H1orf85 35
  • 86.14 (n)
  • 82.18 (a)
C1orf85 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C7H1orf85 35
  • 84.51 (n)
  • 80.65 (a)
C1orf85 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 0610031J06Rik 35
  • 81.57 (n)
  • 80.3 (a)
Glmp 16
0610031J06Rik 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C1H1orf85 35
  • 99.26 (n)
  • 99.26 (a)
C1orf85 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1303130 35
  • 81.48 (n)
  • 80.3 (a)
oppossum
(Monodelphis domestica)
Mammalia C1orf85 36
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C1orf85 36
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC777136 35
  • 56.58 (n)
  • 43.7 (a)
C1orf85 36
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C1orf85 36
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c1orf85 35
  • 53.8 (n)
  • 45.56 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:92308 35
  • 47.67 (n)
  • 37.5 (a)
C19H1orf85 36
  • 33 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004431 35
  • 42.11 (n)
  • 24.67 (a)
Species with no ortholog for GLMP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GLMP Gene

ENSEMBL:
Gene Tree for GLMP (if available)
TreeFam:
Gene Tree for GLMP (if available)

Paralogs for GLMP Gene

No data available for Paralogs for GLMP Gene

Variants for GLMP Gene

Sequence variations from dbSNP and Humsavar for GLMP Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1570805 - 156,294,857(+) GTTGA(C/T)GCTCA intron-variant, nc-transcript-variant, upstream-variant-2KB, reference, missense
rs10908496 - 156,294,209(-) GCCGA(C/T)CAGCC nc-transcript-variant, reference, missense
rs10908495 - 156,294,149(-) CCCTG(A/G)TTGGA nc-transcript-variant, reference, missense
rs1570806 -- 156,294,871(+) TGCTG(G/T)GGGGG intron-variant, nc-transcript-variant, upstream-variant-2KB, reference, missense
rs3123025 -- 156,297,213(+) aaaaa(A/T)ttttt upstream-variant-2KB

Variation tolerance for GLMP Gene

Residual Variation Intolerance Score: 76.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.78; 93.36% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for GLMP Gene

Disorders for GLMP Gene

Relevant External Links for GLMP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GLMP

No disorders were found for GLMP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GLMP Gene

Publications for GLMP Gene

  1. Human NCU-G1 can function as a transcription factor and as a nuclear receptor co-activator. (PMID: 18021396) Steffensen K.R. … Eskild W. (BMC Mol. Biol. 2007) 2 3 4 67
  2. NCU-G1 is a highly glycosylated integral membrane protein of the lysosome. (PMID: 19489740) Schieweck O. … LA1bke T. (Biochem. J. 2009) 2 3 23
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Genome-wide association study of hematological and biochemical traits in a Japanese population. (PMID: 20139978) Kamatani Y. … Kamatani N. (Nat. Genet. 2010) 3

Products for GLMP Gene

Sources for GLMP Gene

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