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Aliases for GLMP Gene

Aliases for GLMP Gene

  • Glycosylated Lysosomal Membrane Protein 2 3 5
  • Kidney Lysosomal Membrane Protein 2 3
  • Lysosomal Protein NCU-G1 3 4
  • C1orf85 3 4
  • Chromosome 1 Open Reading Frame 85 2
  • Kidney Predominant Protein NCU-G1 3
  • NCU-G1 3

External Ids for GLMP Gene

Previous HGNC Symbols for GLMP Gene

  • C1orf85

Summaries for GLMP Gene

GeneCards Summary for GLMP Gene

GLMP (Glycosylated Lysosomal Membrane Protein) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and ligand-dependent nuclear receptor transcription coactivator activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLMP Gene

Genomics for GLMP Gene

Regulatory Elements for GLMP Gene

Enhancers for GLMP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F156281 1.5 FANTOM5 ENCODE 27 +12.4 12432 4.4 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 GLMP SMG5 KIAA0907 PEAR1 SLC25A44 PAQR6 BGLAP ENSG00000252236 SEMA4A TSACC
GH01F156486 1.9 FANTOM5 Ensembl ENCODE 19.2 -203.2 -203175 25.4 MLX CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 ZNF263 RRNAD1 KIAA0907 LOC246784 ENSG00000271267 SSR2 GLMP MEF2D ENSG00000229961 DAP3P1 TSACC
GH01F156336 1.1 ENCODE 26.9 -42.4 -42364 2.9 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 GLMP MSTO2P LOC246784 ENSG00000271267 RRNAD1 ASH1L KIAA0907 PEAR1 ETV3 ASH1L-AS1
GH01F156276 1 Ensembl ENCODE 27 +18.8 18766 1.0 KLF17 CEBPG GLIS2 ZFHX2 POLR2A PATZ1 ZNF600 EGR2 PAF1 MAZ SMG5 PAQR6 GLMP BGLAP SEMA4A ENSG00000252236 SLC25A44 TSACC CCT3 LMNA
GH01F156262 0.7 ENCODE 37.1 +32.7 32664 1.4 PKNOX1 MAFG OSR2 ZNF316 JUND ZNF366 PBX2 SCRT2 NFE2L1 ZBTB33 GLMP SMG5 PAQR6 BGLAP PMF1 SEMA4A SLC25A44 ENSG00000252236 LMNA MEX3A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GLMP on UCSC Golden Path with GeneCards custom track

Promoters for GLMP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001750489 289 1601 TBP HDAC1 ARID4B SIN3A NFXL1 ZBTB40 KLF7 THAP11 ZNF263 ZNF362

Genomic Location for GLMP Gene

Chromosome:
1
Start:
156,290,089 bp from pter
End:
156,295,689 bp from pter
Size:
5,601 bases
Orientation:
Minus strand

Genomic View for GLMP Gene

Genes around GLMP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GLMP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GLMP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLMP Gene

Proteins for GLMP Gene

  • Protein details for GLMP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWB7-GLMP_HUMAN
    Recommended name:
    Glycosylated lysosomal membrane protein
    Protein Accession:
    Q8WWB7
    Secondary Accessions:
    • A6NH16
    • B4DJN4
    • Q5SZX4
    • Q6UX96
    • Q8IV07
    • Q96F65

    Protein attributes for GLMP Gene

    Size:
    406 amino acids
    Molecular mass:
    43864 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH11575.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI14165.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for GLMP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GLMP Gene

Post-translational modifications for GLMP Gene

  • Highly N-glycosylated.
  • Glycosylation at Asn 65, Asn 134, Asn 159, Asn 187, and Asn 230
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GLMP Gene

Domains & Families for GLMP Gene

Protein Domains for GLMP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GLMP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WWB7

UniProtKB/Swiss-Prot:

GLMP_HUMAN :
  • Belongs to the GLMP family.
Family:
  • Belongs to the GLMP family.
genes like me logo Genes that share domains with GLMP: view

No data available for Gene Families for GLMP Gene

Function for GLMP Gene

Molecular function for GLMP Gene

UniProtKB/Swiss-Prot Induction:
Transcription is activated by TFEB.

Gene Ontology (GO) - Molecular Function for GLMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 transcription factor activity, sequence-specific DNA binding IMP 18021396
GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding IMP 18021396
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity IDA 18021396
GO:0044212 transcription regulatory region DNA binding IDA 18021396
genes like me logo Genes that share ontologies with GLMP: view
genes like me logo Genes that share phenotypes with GLMP: view

Animal Model Products

miRNA for GLMP Gene

miRTarBase miRNAs that target GLMP

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GLMP Gene

Localization for GLMP Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLMP Gene

Lysosome membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GLMP gene
Compartment Confidence
cytosol 5
lysosome 5
nucleus 4
plasma membrane 3
extracellular 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GLMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 18021396
GO:0005764 lysosome IEA,IDA 19556463
GO:0005765 lysosomal membrane IEA --
GO:0005829 cytosol IDA 18021396
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with GLMP: view

Pathways & Interactions for GLMP Gene

No Data Available

Interacting Proteins for GLMP Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000354553%0d%0a9606.ENSP00000264951%0d%0a
Selected Interacting proteins: Q8WWB7-GLMP_HUMAN ENSP00000354553 for GLMP Gene via IID STRING

Gene Ontology (GO) - Biological Process for GLMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030522 intracellular receptor signaling pathway IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IMP 18021396
genes like me logo Genes that share ontologies with GLMP: view

No data available for Pathways by source and SIGNOR curated interactions for GLMP Gene

Transcripts for GLMP Gene

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GLMP Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c
SP1: - -
SP2: - - -
SP3: - -
SP4: - - - - -
SP5: - - -
SP6:

Relevant External Links for GLMP Gene

GeneLoc Exon Structure for
GLMP
ECgene alternative splicing isoforms for
GLMP

Expression for GLMP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GLMP Gene

Protein differential expression in normal tissues from HIPED for GLMP Gene

This gene is overexpressed in Amniocyte (38.3) and Liver (20.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GLMP Gene



NURSA nuclear receptor signaling pathways regulating expression of GLMP Gene:

GLMP
genes like me logo Genes that share expression patterns with GLMP: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for GLMP Gene

Orthologs for GLMP Gene

This gene was present in the common ancestor of animals.

Orthologs for GLMP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1H1orf85 34
  • 99.26 (n)
C1orf85 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C3H1orf85 34
  • 86.14 (n)
C1orf85 35
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C7H1orf85 34
  • 84.51 (n)
C1orf85 35
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 0610031J06Rik 34 35
  • 81.57 (n)
Glmp 16
rat
(Rattus norvegicus)
Mammalia RGD1303130 34
  • 81.48 (n)
oppossum
(Monodelphis domestica)
Mammalia C1orf85 35
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C1orf85 35
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC777136 34
  • 56.58 (n)
C1orf85 35
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C1orf85 35
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c1orf85 34
  • 53.8 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:92308 34
  • 47.67 (n)
C19H1orf85 35
  • 33 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004431 34
  • 42.11 (n)
Species where no ortholog for GLMP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GLMP Gene

ENSEMBL:
Gene Tree for GLMP (if available)
TreeFam:
Gene Tree for GLMP (if available)

Paralogs for GLMP Gene

No data available for Paralogs for GLMP Gene

Variants for GLMP Gene

Sequence variations from dbSNP and Humsavar for GLMP Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10908494 -- 156,293,306(+) CCCAA(A/G)CCCTG intron-variant, upstream-variant-2KB
rs10908495 -- 156,294,149(-) CCCTG(A/G)TTGGA nc-transcript-variant, reference, missense
rs10908496 -- 156,294,209(-) GCCGA(C/T)CAGCC nc-transcript-variant, reference, missense
rs112378379 -- 156,292,694(+) CCTGT(A/G)AAAAA intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs112421210 -- 156,293,730(+) AGTTC(A/G)ACTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GLMP Gene

Variant ID Type Subtype PubMed ID
nsv547968 CNV loss 21841781
nsv509524 CNV insertion 20534489

Variation tolerance for GLMP Gene

Residual Variation Intolerance Score: 76.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.78; 93.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GLMP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GLMP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLMP Gene

Disorders for GLMP Gene

Relevant External Links for GLMP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GLMP

No disorders were found for GLMP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GLMP Gene

Publications for GLMP Gene

  1. NCU-G1 is a highly glycosylated integral membrane protein of the lysosome. (PMID: 19489740) Schieweck O. … LA1bke T. (Biochem. J. 2009) 2 3 22 64
  2. Human NCU-G1 can function as a transcription factor and as a nuclear receptor co-activator. (PMID: 18021396) Steffensen K.R. … Eskild W. (BMC Mol. Biol. 2007) 2 3 4 64
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 64
  4. A gene network regulating lysosomal biogenesis and function. (PMID: 19556463) Sardiello M. … Ballabio A. (Science 2009) 3 4 64
  5. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4 64

Products for GLMP Gene

Sources for GLMP Gene

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