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Aliases for GLMP Gene

Aliases for GLMP Gene

  • Glycosylated Lysosomal Membrane Protein 2 3 5
  • Kidney Lysosomal Membrane Protein 2 3
  • Lysosomal Protein NCU-G1 3 4
  • C1orf85 3 4
  • Chromosome 1 Open Reading Frame 85 2
  • Kidney Predominant Protein NCU-G1 3
  • NCU-G1 3

External Ids for GLMP Gene

Previous HGNC Symbols for GLMP Gene

  • C1orf85

Summaries for GLMP Gene

GeneCards Summary for GLMP Gene

GLMP (Glycosylated Lysosomal Membrane Protein) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and ligand-dependent nuclear receptor transcription coactivator activity.

Additional gene information for GLMP Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLMP Gene

Genomics for GLMP Gene

Regulatory Elements for GLMP Gene

Enhancers for GLMP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H156281 1.8 FANTOM5 ENCODE dbSUPER 27.1 +12.4 12432 4 MLX ZFP64 DMAP1 YY1 ZNF143 SP3 NFYC PPARGC1A MEF2D SSRP1 GLMP SMG5 SLC25A44 PAQR6 BGLAP GON4L DAP3 ENSG00000252236 SEMA4A YY1AP1
GH01H155561 1.7 FANTOM5 ENCODE dbSUPER 19.5 +732.2 732207 3 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B CLK2 GON4L SSR2 THBS3 GLMP KIAA0907 ENSG00000271267 SHC1 RUSC1-AS1 DPM3
GH01H156290 1.2 ENCODE dbSUPER 27.4 +3.8 3772 2 MLX ARID4B DMAP1 YY1 SLC30A9 SP3 SP5 MXD4 REST PPARG PAQR6 GLMP BGLAP TSACC CCT3 MIR9-1 C1orf61 LAMTOR2 UBQLN4 KIAA0907
GH01H156243 1.3 Ensembl ENCODE dbSUPER 24.1 +49.4 49359 4 ELF3 SOX13 KLF1 MAX BACH1 KLF17 ZFHX2 GLIS2 POLR2A ZNF143 SMG5 GLMP PAQR6 BGLAP
GH01H156336 1.1 ENCODE 26.9 -42.4 -42364 2 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A YBX1 DMAP1 ZNF2 GON4L GLMP RRNAD1 YY1AP1 DAP3 MSTO2P LOC246784 ENSG00000271267 ISG20L2 KIAA0907
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GLMP on UCSC Golden Path with GeneCards custom track

Promoters for GLMP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000014179 89 801 ARID4B SIN3A KLF7 RUNX3 DEK SP3 MXD4 REST ZNF518A KAT8

Genomic Location for GLMP Gene

Chromosome:
1
Start:
156,290,089 bp from pter
End:
156,295,689 bp from pter
Size:
5,601 bases
Orientation:
Minus strand

Genomic View for GLMP Gene

Genes around GLMP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GLMP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GLMP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLMP Gene

Proteins for GLMP Gene

  • Protein details for GLMP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWB7-GLMP_HUMAN
    Recommended name:
    Glycosylated lysosomal membrane protein
    Protein Accession:
    Q8WWB7
    Secondary Accessions:
    • A6NH16
    • B4DJN4
    • Q5SZX4
    • Q6UX96
    • Q8IV07
    • Q96F65

    Protein attributes for GLMP Gene

    Size:
    406 amino acids
    Molecular mass:
    43864 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH11575.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI14165.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for GLMP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GLMP Gene

Post-translational modifications for GLMP Gene

  • Highly N-glycosylated.
  • Glycosylation at posLast=6565, posLast=134134, isoforms=2159, isoforms=2187, and posLast=230230
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GLMP Gene

Domains & Families for GLMP Gene

Gene Families for GLMP Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for GLMP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GLMP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WWB7

UniProtKB/Swiss-Prot:

GLMP_HUMAN :
  • Belongs to the GLMP family.
Family:
  • Belongs to the GLMP family.
genes like me logo Genes that share domains with GLMP: view

Function for GLMP Gene

Molecular function for GLMP Gene

UniProtKB/Swiss-Prot Induction:
Transcription is activated by TFEB.

Phenotypes From GWAS Catalog for GLMP Gene

Gene Ontology (GO) - Molecular Function for GLMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 transcription factor activity, sequence-specific DNA binding IMP 18021396
GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding IMP 18021396
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity IDA 18021396
GO:0044212 transcription regulatory region DNA binding IDA 18021396
genes like me logo Genes that share ontologies with GLMP: view
genes like me logo Genes that share phenotypes with GLMP: view

Animal Models for GLMP Gene

MGI Knock Outs for GLMP:

Animal Model Products

CRISPR Products

miRNA for GLMP Gene

miRTarBase miRNAs that target GLMP

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for GLMP
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GLMP Gene

Localization for GLMP Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLMP Gene

Lysosome membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GLMP gene
Compartment Confidence
cytosol 5
lysosome 5
nucleus 4
plasma membrane 3
extracellular 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GLMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 18021396
GO:0005764 lysosome IEA,IDA 19556463
GO:0005765 lysosomal membrane IEA --
GO:0005829 cytosol IDA 18021396
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with GLMP: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GLMP Gene

Pathways & Interactions for GLMP Gene

No Data Available

Interacting Proteins for GLMP Gene

Gene Ontology (GO) - Biological Process for GLMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030522 intracellular receptor signaling pathway IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IMP 18021396
genes like me logo Genes that share ontologies with GLMP: view

No data available for Pathways by source and SIGNOR curated interactions for GLMP Gene

Drugs & Compounds for GLMP Gene

No Compound Related Data Available

Transcripts for GLMP Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for GLMP
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for GLMP Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c
SP1: - -
SP2: - - -
SP3: - -
SP4: - - - - -
SP5: - - -
SP6:

Relevant External Links for GLMP Gene

GeneLoc Exon Structure for
GLMP
ECgene alternative splicing isoforms for
GLMP

Expression for GLMP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GLMP Gene

Protein differential expression in normal tissues from HIPED for GLMP Gene

This gene is overexpressed in Amniocyte (38.3) and Liver (20.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GLMP Gene



NURSA nuclear receptor signaling pathways regulating expression of GLMP Gene:

GLMP

Evidence on tissue expression from TISSUES for GLMP Gene

  • Skin(4.3)
  • Intestine(4.2)
  • Spleen(4.2)
  • Nervous system(4.2)
  • Liver(2.1)
  • Kidney(2)
genes like me logo Genes that share expression patterns with GLMP: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GLMP Gene

Orthologs for GLMP Gene

This gene was present in the common ancestor of animals.

Orthologs for GLMP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1H1orf85 33
  • 99.26 (n)
C1orf85 34
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C3H1orf85 33
  • 86.14 (n)
C1orf85 34
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C7H1orf85 33
  • 84.51 (n)
C1orf85 34
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 0610031J06Rik 34 33
  • 81.57 (n)
OneToOne
Glmp 16
rat
(Rattus norvegicus)
Mammalia RGD1303130 33
  • 81.48 (n)
oppossum
(Monodelphis domestica)
Mammalia C1orf85 34
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C1orf85 34
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC777136 33
  • 56.58 (n)
C1orf85 34
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C1orf85 34
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c1orf85 33
  • 53.8 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:92308 33
  • 47.67 (n)
C19H1orf85 34
  • 33 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004431 33
  • 42.11 (n)
Species where no ortholog for GLMP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GLMP Gene

ENSEMBL:
Gene Tree for GLMP (if available)
TreeFam:
Gene Tree for GLMP (if available)

Paralogs for GLMP Gene

No data available for Paralogs for GLMP Gene

Variants for GLMP Gene

Sequence variations from dbSNP and Humsavar for GLMP Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1001191777 -- 156,296,921(+) AACAA(A/G)GGGCA upstream-variant-2KB
rs1001550071 -- 156,292,248(+) AGAAG(A/G)CATGC intron-variant, nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs1002147218 -- 156,292,524(+) ACCTC(C/T)CAGCT intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1003205872 -- 156,293,445(+) GAGTA(G/T)GCTAA intron-variant, upstream-variant-2KB, reference, synonymous-codon
rs1003646472 -- 156,293,705(+) CAATC(C/G)CTCCT intron-variant, nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for GLMP Gene

Variant ID Type Subtype PubMed ID
nsv509524 CNV insertion 20534489
nsv547968 CNV loss 21841781

Variation tolerance for GLMP Gene

Residual Variation Intolerance Score: 76.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.78; 93.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GLMP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GLMP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLMP Gene

Disorders for GLMP Gene

Relevant External Links for GLMP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GLMP

No disorders were found for GLMP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GLMP Gene

Publications for GLMP Gene

  1. NCU-G1 is a highly glycosylated integral membrane protein of the lysosome. (PMID: 19489740) Schieweck O … Lübke T (The Biochemical journal 2009) 2 3 22 60
  2. Human NCU-G1 can function as a transcription factor and as a nuclear receptor co-activator. (PMID: 18021396) Steffensen KR … Eskild W (BMC molecular biology 2007) 2 3 4 60
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 60
  4. A gene network regulating lysosomal biogenesis and function. (PMID: 19556463) Sardiello M … Ballabio A (Science (New York, N.Y.) 2009) 3 4 60
  5. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 60

Products for GLMP Gene

Sources for GLMP Gene

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