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Aliases for GLIS3 Gene

Aliases for GLIS3 Gene

  • GLIS Family Zinc Finger 3 2 3 5
  • Zinc Finger Protein 515 2 3 4
  • GLI-Similar 3 3 4
  • ZNF515 3 4
  • OK/KNS-Cl.4 3

External Ids for GLIS3 Gene

Previous HGNC Symbols for GLIS3 Gene

  • ZNF515

Summaries for GLIS3 Gene

Entrez Gene Summary for GLIS3 Gene

  • This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear protein with five C2H2-type zinc finger domains. This protein functions as both a repressor and activator of transcription and is specifically involved in the development of pancreatic beta cells, the thyroid, eye, liver and kidney. Mutations in this gene have been associated with neonatal diabetes and congenital hypothyroidism (NDH). Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only two have been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for GLIS3 Gene

GLIS3 (GLIS Family Zinc Finger 3) is a Protein Coding gene. Diseases associated with GLIS3 include Diabetes Mellitus, Neonatal, With Congenital Hypothyroidism and Neonatal Diabetes-Congenital Hypothyroidism-Congenital Glaucoma-Hepatic Fibrosis-Polycystic Kidneys Syndrome. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding. An important paralog of this gene is ZIC3.

UniProtKB/Swiss-Prot for GLIS3 Gene

  • Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5-GACCACCCAC-3 (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLIS3 Gene

Genomics for GLIS3 Gene

Regulatory Elements for GLIS3 Gene

Enhancers for GLIS3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GLIS3 on UCSC Golden Path with GeneCards custom track

Genomic Location for GLIS3 Gene

3,824,127 bp from pter
4,348,392 bp from pter
524,266 bases
Minus strand

Genomic View for GLIS3 Gene

Genes around GLIS3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GLIS3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GLIS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLIS3 Gene

Proteins for GLIS3 Gene

  • Protein details for GLIS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein GLIS3
    Protein Accession:
    Secondary Accessions:
    • B1AL19
    • Q1PHK5

    Protein attributes for GLIS3 Gene

    775 amino acids
    Molecular mass:
    83636 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GLIS3 Gene


neXtProt entry for GLIS3 Gene

Proteomics data for GLIS3 Gene at MOPED

Post-translational modifications for GLIS3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GLIS3 Gene

Domains & Families for GLIS3 Gene

Gene Families for GLIS3 Gene

Protein Domains for GLIS3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GLI C2H2-type zinc-finger protein family.
  • Contains 5 C2H2-type zinc fingers.
  • Belongs to the GLI C2H2-type zinc-finger protein family.
  • Contains 5 C2H2-type zinc fingers.
genes like me logo Genes that share domains with GLIS3: view

Function for GLIS3 Gene

Molecular function for GLIS3 Gene

UniProtKB/Swiss-Prot Function:
Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5-GACCACCCAC-3 (By similarity).
genes like me logo Genes that share phenotypes with GLIS3: view

Human Phenotype Ontology for GLIS3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for GLIS3 Gene

MGI Knock Outs for GLIS3:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for GLIS3 Gene

Localization for GLIS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLIS3 Gene

Subcellular locations from

Jensen Localization Image for GLIS3 Gene COMPARTMENTS Subcellular localization image for GLIS3 gene
Compartment Confidence
golgi apparatus 5
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for GLIS3 Gene

Pathways & Interactions for GLIS3 Gene

SuperPathways for GLIS3 Gene

No Data Available

SIGNOR curated interactions for GLIS3 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for GLIS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter ISS --
genes like me logo Genes that share ontologies with GLIS3: view

No data available for Pathways by source for GLIS3 Gene

Drugs & Compounds for GLIS3 Gene

No Compound Related Data Available

Transcripts for GLIS3 Gene

Unigene Clusters for GLIS3 Gene

GLIS family zinc finger 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GLIS3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
SP1: -

Relevant External Links for GLIS3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GLIS3 Gene

mRNA expression in normal human tissues for GLIS3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GLIS3 Gene

This gene is overexpressed in Plasma (68.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GLIS3 Gene

SOURCE GeneReport for Unigene cluster for GLIS3 Gene Hs.162125

mRNA Expression by UniProt/SwissProt for GLIS3 Gene

Tissue specificity: In the adult, expressed at high levels in the kidney and at lower levels in the brain, skeletal muscle, pancreas, liver, lung, thymus and ovary.
genes like me logo Genes that share expression patterns with GLIS3: view

Protein tissue co-expression partners for GLIS3 Gene

Primer Products

No data available for mRNA differential expression in normal tissues for GLIS3 Gene

Orthologs for GLIS3 Gene

This gene was present in the common ancestor of animals.

Orthologs for GLIS3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GLIS3 35
  • 87.8 (n)
  • 88.36 (a)
GLIS3 36
  • 78 (a)
(Canis familiaris)
Mammalia GLIS3 35
  • 87.6 (n)
  • 87.31 (a)
GLIS3 36
  • 88 (a)
(Mus musculus)
Mammalia Glis3 35
  • 84.34 (n)
  • 84.16 (a)
Glis3 16
Glis3 36
  • 84 (a)
(Pan troglodytes)
Mammalia GLIS3 35
  • 98.67 (n)
  • 98.28 (a)
GLIS3 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Glis3 35
  • 84.23 (n)
  • 84.05 (a)
(Monodelphis domestica)
Mammalia GLIS3 36
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia GLIS3 36
  • 81 (a)
(Gallus gallus)
Aves GLIS3 35
  • 69.55 (n)
  • 65.52 (a)
GLIS3 36
  • 65 (a)
(Anolis carolinensis)
Reptilia GLIS3 36
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia glis3 35
  • 68.49 (n)
  • 69.54 (a)
(Danio rerio)
Actinopterygii glis3 35
  • 60.63 (n)
  • 56.62 (a)
glis3 36
  • 45 (a)
fruit fly
(Drosophila melanogaster)
Insecta lmd 36
  • 25 (a)
(Caenorhabditis elegans)
Secernentea tra-1 36
  • 14 (a)
ztf-14 36
  • 25 (a)
Species with no ortholog for GLIS3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GLIS3 Gene

Gene Tree for GLIS3 (if available)
Gene Tree for GLIS3 (if available)

Paralogs for GLIS3 Gene

genes like me logo Genes that share paralogs with GLIS3: view

Variants for GLIS3 Gene

Sequence variations from dbSNP and Humsavar for GLIS3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs6415788 - 4,118,111(+) GGCCT(G/T)GGGGC nc-transcript-variant, reference, missense
rs806052 - 4,118,208(-) GCCAG(C/T)CGGCC nc-transcript-variant, reference, missense
rs10973986 - 3,879,526(+) TGACA(A/G)GATGT reference, missense
rs635006 -- 4,122,496(-) AGAAA(A/T)TCTTG intron-variant
rs635171 -- 3,961,492(+) CTCTA(A/G)TAAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GLIS3 Gene

Variant ID Type Subtype PubMed ID
nsv892097 CNV Gain 21882294
nsv892098 CNV Gain 21882294
esv2672805 CNV Deletion 23128226
nsv528551 CNV Loss 19592680
nsv892099 CNV Gain 21882294
esv2218450 CNV Deletion 18987734
esv2423311 CNV Insertion 19546169
nsv892100 CNV Gain 21882294
nsv892101 CNV Gain 21882294
nsv892102 CNV Gain 21882294
esv2738148 CNV Deletion 23290073
nsv892103 CNV Gain 21882294
nsv518476 CNV Loss 19592680
esv2673095 CNV Deletion 23128226
esv2666704 CNV Deletion 23128226
dgv2275e1 CNV Complex 17122850
nsv438089 CNV Loss 16468122
esv2662838 CNV Deletion 23128226
nsv892104 CNV Gain 21882294
nsv892105 CNV Gain 21882294
nsv6458 CNV Insertion 18451855
nsv519359 CNV Loss 19592680
nsv416336 CNV Loss 16902084
esv2105371 CNV Deletion 18987734
esv2442988 CNV Deletion 19546169
esv275424 CNV Gain+Loss 21479260
nsv892106 CNV Gain 21882294
nsv892107 CNV Gain 21882294
nsv517705 CNV Loss 19592680
nsv892108 CNV Gain 21882294
esv2657927 CNV Deletion 23128226
nsv520350 CNV Gain+Loss 19592680
esv22225 CNV Loss 19812545
nsv892109 CNV Gain 21882294
nsv524574 CNV Gain 19592680
nsv892110 CNV Gain 21882294
esv272802 CNV Insertion 20981092
esv268661 CNV Insertion 20981092
nsv892111 CNV Gain 21882294
esv27658 CNV Loss 19812545
nsv892112 CNV Gain 21882294

Variation tolerance for GLIS3 Gene

Residual Variation Intolerance Score: 80.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.42; 71.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GLIS3 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLIS3 Gene

Disorders for GLIS3 Gene

MalaCards: The human disease database

(6) MalaCards diseases for GLIS3 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search GLIS3 in MalaCards View complete list of genes associated with diseases


  • Diabetes mellitus, neonatal, with congenital hypothyroidism (NDH) [MIM:610199]: A syndrome of neonatal diabetes syndrome associated with congenital hypothyroidism, congenital glaucoma, hepatic fibrosis and polycystic kidneys. {ECO:0000269 PubMed:16715098, ECO:0000269 PubMed:21139041}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for GLIS3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GLIS3: view

No data available for Genatlas for GLIS3 Gene

Publications for GLIS3 Gene

  1. GLIS3, a novel member of the GLIS subfamily of Kruppel-like zinc finger proteins with repressor and activation functions. (PMID: 14500813) Kim Y.-S. … Jetten A.M. (Nucleic Acids Res. 2003) 2 3 4 67
  2. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X. … Vidal M. (Cell 2016) 3
  3. Genomic analysis of fibrolamellar hepatocellular carcinoma. (PMID: 25122662) Xu L. … Sage J. (Hum. Mol. Genet. 2015) 3
  4. Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians. (PMID: 25187374) Hwang J.Y. … Kim B.J. (Diabetes 2015) 3
  5. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3

Products for GLIS3 Gene

Sources for GLIS3 Gene