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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GLIS2 Gene

protein-coding   GIFtS: 50
GCID: GC16P004365

GLIS Family Zinc Finger 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
GLIS Family Zinc Finger 21 2     NPHP72 5
nephrocystin-71 2     GLI-Similar Protein 22
Neuronal Krueppel-Like Protein2 3     Kruppel-Like Zinc Finger Protein GLIS22
NKL2 3     Zinc Finger Protein GLIS22
GLI-Similar 22 3     

External Ids:    HGNC: 294501   Entrez Gene: 846622   Ensembl: ENSG000001266037   OMIM: 6085395   UniProtKB: Q9BZE03   

Export aliases for GLIS2 gene to outside databases

Previous GC identifers: GC16P004405 GC16P004382 GC16P004304


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GLIS2 Gene:
This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear transcription factor
with five C2H2-type zinc finger domains. The protein encoded by this gene is widely expressed at low levels in
the neural tube and peripheral nervous system and likely promotes neuronal differentiation. It is abundantly
expressed in the kidney and may have a role in the regulation of kidney morphogenesis. p120 regulates the
expression level of this protein and induces the cleavage of this protein's C-terminal zinc finger domain. This
protein also promotes the nuclear translocation of p120. Mutations in this gene cause nephronophthisis (NPHP), an
autosomal recessive kidney disease characterized by tubular basement membrane disruption, interstitial
lymphohistiocytic cell infiltration, and development of cysts at the corticomedullary border of the
kidneys.(provided by RefSeq, Jan 2010)

GeneCards Summary for GLIS2 Gene: 
GLIS2 (GLIS family zinc finger 2) is a protein-coding gene. Diseases associated with GLIS2 include nephronophthisis 7, and acute megakaryoblastic leukemia without down syndrome. GO annotations related to this gene include RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription and transcription regulatory region DNA binding. An important paralog of this gene is MTF1.

UniProtKB/Swiss-Prot: GLIS2_HUMAN, Q9BZE0
Function: Can act either as a transcriptional repressor or as a transcriptional activator, depending on the cell
context. Acts as a repressor of the Hedgehog signaling pathway (By similarity). Represses the Hedgehog-dependent
expression of Wnt4 (By similarity). Necessary to maintain the differentiated epithelial phenotype in renal cells
through the inhibition of SNAI1, which itself induces the epithelial-to-mesenchymal transition (By similarity).
Represses transcriptional activation mediated by CTNNB1 in the Wnt signaling pathway. May act by recruiting the
corepressors CTBP1 and HDAC3. May be involved in neuron differentiation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010393.16  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GLIS2 gene promoter:
         COUP-TF1   COUP-TF   COUP   E2F-2   HNF-4alpha2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGLIS2 promoter sequence
   Search SABiosciences Chromatin IP Primers for GLIS2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GLIS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

GLIS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GLIS2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P004365:  view genomic region     (about GC identifiers)

Start:
4,364,762 bp from pter      End:
4,389,598 bp from pter
Size:
24,837 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GLIS2_HUMAN, Q9BZE0 (See protein sequence)
Recommended Name: Zinc finger protein GLIS2  
Size: 524 amino acids; 55689 Da
Subunit: Interacts with CTBP1 and HDAC3 (By similarity). Interacts with CTNNB1 (By similarity). Interacts with
SUFU (By similarity). Interacts with CTNND1
Subcellular location: Nucleus speckle (By similarity). Cytoplasm (By similarity)
Secondary accessions: B3KX84

Explore the universe of human proteins at neXtProt for GLIS2: NX_Q9BZE0

Explore proteomics data for GLIS2 at MOPED 

Post-translational modifications:

  • UniProtKB: C-terminus cleavage is induced by interaction with CTNND1 and enhanced by Src tyrosine kinase (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BZE0

  • GLIS2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GLIS2 Protein Expression
    REFSEQ proteins: NP_115964.2  
    ENSEMBL proteins: 
     ENSP00000262366   ENSP00000395547  

    Human Recombinant Protein Products for GLIS2: 
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    Novus Biologicals GLIS2 Protein
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm IEA--
    GO:0016607nuclear speck ISS--

    GLIS2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9BZE0

    ProtoNet protein and cluster: Q9BZE0

    UniProtKB/Swiss-Prot: GLIS2_HUMAN, Q9BZE0
    Domain: The C2H2-type zinc finger 1 has a major repressor function and is required for CTNNB1 binding (By
    similarity)
    Similarity: Belongs to the GLI C2H2-type zinc-finger protein family
    Similarity: Contains 5 C2H2-type zinc fingers


    GLIS2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GLIS2_HUMAN, Q9BZE0
    Function: Can act either as a transcriptional repressor or as a transcriptional activator, depending on the cell
    context. Acts as a repressor of the Hedgehog signaling pathway (By similarity). Represses the Hedgehog-dependent
    expression of Wnt4 (By similarity). Necessary to maintain the differentiated epithelial phenotype in renal cells
    through the inhibition of SNAI1, which itself induces the epithelial-to-mesenchymal transition (By similarity).
    Represses transcriptional activation mediated by CTNNB1 in the Wnt signaling pathway. May act by recruiting the
    corepressors CTBP1 and HDAC3. May be involved in neuron differentiation (By similarity)

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription ISS--
    GO:0003677DNA binding ----
    GO:0005515protein binding IPI17289029
    GO:0008270zinc ion binding ----
    GO:0044212transcription regulatory region DNA binding ISS--
         
    GLIS2 for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Glis2):
     behavior/neurological  cellular  homeostasis/metabolism  immune system  mortality/aging 
     renal/urinary system 

    GLIS2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Glis2tm1Amj for GLIS2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for GLIS2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GLIS2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GLIS2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GLIS2 

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidGLIS2 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GLIS2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GLIS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/9 Interacting proteins for GLIS2 (Q9BZE02, 3 ENSP000002623664) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CPSF1Q105702, 3, ENSP000003393534MINT-4651600 I2D: score=2 STRING: ENSP00000339353
    GPSM2P812742, 3, ENSP000002641264MINT-4651583 I2D: score=2 STRING: ENSP00000264126
    CTNNB1P352222, 3, ENSP000003444564MINT-4651651 MINT-4651688 MINT-4651707 MINT-4651725 MINT-4651770 MINT-4651668 I2D: score=3 STRING: ENSP00000344456
    RBFOX2O432512, 3, ENSP000004130354MINT-4651634 I2D: score=2 STRING: ENSP00000413035
    SPECC1LQ69YQ02, 3, ENSP000003257854MINT-4651617 I2D: score=2 STRING: ENSP00000325785
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ISS--
    GO:0007399nervous system development IEA--
    GO:0030154cell differentiation IEA--
    GO:0043433negative regulation of sequence-specific DNA binding transcription factor activity ISS--
    GO:0045879negative regulation of smoothened signaling pathway ISS--

    GLIS2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GLIS2

    Search CenterWatch for drugs/clinical trials and news about GLIS2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GLIS2 gene: 
    NM_032575.2  

    Unigene Cluster for GLIS2:

    GLIS family zinc finger 2
    Hs.592087  [show with all ESTs]
    Unigene Representative Sequence: AK126918
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262366(uc002cwc.1) ENST00000433375
    miRNA
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    8/48 QIAGEN miScript miRNA Assays for microRNAs that regulate GLIS2 (see all 48):
    hsa-miR-4254 hsa-miR-1321 hsa-miR-3146 hsa-miR-429 hsa-miR-330-5p hsa-miR-765 hsa-miR-29a hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmidGLIS2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for GLIS2
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    GenScript: all cDNA clones in your preferred vector: GLIS2 (NM_032575)
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GLIS2

    Additional mRNA sequence: 

    AF325914.1 AK095566.1 AK096936.1 AK124985.1 AK126918.1 BC033763.1 

    4 DOTS entries:

    DT.101978531  DT.100651350  DT.95267761  DT.99974263 

    24/105 AceView cDNA sequences (see all 105):

    BQ773307 AK096936 AK126918 BM128159 AA991329 BE780504 BM128620 BQ446334 
    AW452966 AW192155 BU622615 BE350696 CD673569 BF516077 BM980716 AI474881 
    AI362896 AK095566 AI206871 BM556436 BM021288 CD673568 BQ693977 AI831073 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GLIS2 expression in normal human tissues (normalized intensities)      GLIS2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAGAGGAAG
    GLIS2 Expression
    About this image


    GLIS2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow

    See GLIS2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GLIS2

    SOURCE GeneReport for Unigene cluster: Hs.592087

    UniProtKB/Swiss-Prot: GLIS2_HUMAN, Q9BZE0
    Tissue specificity: Expressed at high levels in kidney and at low levels in heart, lung and placenta. Expressed in
    colon

        SABiosciences Expression via Pathway-Focused PCR Array including GLIS2: 
              Primary Cilia in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GLIS2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for GLIS2 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Glis21 , 5 GLIS family zinc finger 21, 5 87.65(n)1
    93.28(a)1
      16 (2.45 cM)5
    833961  NM_031184.31  NP_112461.21 
     45947135 
    African clawed frog
    (Xenopus laevis)
    Amphibia NKL2 Gli-Kruppel zinc-finger protein NKL isoform a 77.35(n)    AF249341.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.115592 Transcribed sequence with weak similarity to protein more 77.09(n)    57093496 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG38503   -- 58(a)
    (best of 2)
      49E1   --
    worm
    (Caenorhabditis elegans)
    Secernentea tra-13 Expression: all stages 54(a)   III(11243739-11266707)   --


    ENSEMBL Gene Tree for GLIS2 (if available)
    TreeFam Gene Tree for GLIS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GLIS2 gene
    MTF12  ZIC32  ZNF4102  ZNF762  GLI12  ZIC22  ZIC12  GLI22  
    ZIC42  GLIS12  ZNF1432  GLIS32  ZIC52  GLI32  
    2 SIMAP similar genes for GLIS2 using alignment to 1 protein entry:     GLIS2_HUMAN:
    ZNF323    ZIC1

    GLIS2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/270 SNPs in GLIS2 are shown (see all 270)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1916680681,2
    --4316068(+) ACAGCA/CTGGGA 1 -- us2k10--------
    rs1847875051,2
    --4316119(+) TCTACA/GTATTT 1 -- us2k10--------
    rs1492565831,2
    --4316136(+) TAACCA/GCCAGA 1 -- us2k10--------
    rs1438134011,2
    --4316310(+) TTCTCA/GGTTTG 1 -- us2k10--------
    rs1123246651,2
    C--4316338(+) GGTGGT/GGAGCG 1 -- us2k12Minor allele frequency- G:0.07NA 122
    rs1481760741,2
    --4316419(+) CAGGGC/TGGGAG 1 -- us2k10--------
    rs1429324831,2
    --4316428(+) AGTCCA/GGAGCA 1 -- us2k10--------
    rs1877214351,2
    --4316560(+) CAAAAC/GTGGCC 1 -- us2k10--------
    rs1923901921,2
    --4316582(+) CTCTGC/TAGCGC 1 -- us2k10--------
    rs1461131941,2
    --4316585(+) TGCAGC/TGCTGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for GLIS2 (4364762 - 4389598 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for GLIS2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv471075CNV Loss18288195
    dgv2586n71CNV Loss21882294
    nsv905222CNV Loss21882294
    dgv2585n71CNV Loss21882294
    nsv527866CNV Loss19592680
    nsv905224CNV Loss21882294
    nsv905223CNV Loss21882294


    Human Gene Mutation Database (HGMD): GLIS2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing GLIS2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608539   
    OMIM disorders: 611498  
    UniProtKB/Swiss-Prot: GLIS2_HUMAN, Q9BZE0
  • Nephronophthisis 7 (NPHP7) [MIM:611498]: An autosomal recessive disorder resulting in end-stage renal
    disease during childhood or adolescence. It is a progressive tubulo-interstitial kidney disorder histologically
    characterized by modifications of the tubules with thickening of the basement membrane, interstitial fibrosis
    and, in the advanced stages, medullary cysts. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • 10 diseases for GLIS2:    About MalaCards
    nephronophthisis 7    acute megakaryoblastic leukemia without down syndrome    natural killer cell leukemia    nephronophthisis
    senior-loken syndrome    cystic kidney    neuronitis    kidney disease
    t-cell leukemia    leukemia

    2 diseases from the University of Copenhagen DISEASES database for GLIS2:
    Nephronophthisis     Cystic kidney

    GLIS2 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: GLIS2 (1 document)

    Export disorders for GLIS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GLIS2 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with GLIS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Loss of GLIS2 causes nephronophthisis in humans and mice by increased apoptosis and fibrosis. (PubMed id 17618285)1, 2, 3 Attanasio M....Treier M. (2007)
    2. Genomic structure of the gene encoding the human GLI-related, Kruppel-like zinc finger protein GLIS2. (PubMed id 11738817)1, 2, 9 Zhang F. and Jetten A.M. (2001)
    3. The transcriptional repressor Glis2 is a novel binding partner for p120 catenin. (PubMed id 17344476)1, 2 Hosking C.R.... Fujita Y. (2007)
    4. The Kruppel-like zinc finger protein Glis2 functions as a negative modulator of the Wnt/beta-catenin signaling pathway. (PubMed id 17289029)1, 2 Kim Y.-S.... Jetten A.M. (2007)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. GLIS3, a novel member of the GLIS subfamily of Kruppel-like zinc finger proteins with repressor and activation functions. (PubMed id 14500813)1, 3 Kim Y.-S.... Jetten A.M. (2003)
    7. Characterization of Glis2, a novel gene encoding a Gli-related, Kruppel-like transcription factor with transactivation and repressor functions. Roles in kidney development and neurogenesis. (PubMed id 11741991)1, 3 Zhang F....Jetten A.M. (2002)
    8. Identification of NKL, a novel Gli-Kruppel zinc-finger protein that promotes neuronal differentiation. (PubMed id 11262234)1, 2 Lamar E.... Goulding M. (2001)
    9. An Inv(16)(p13.3q24.3)-encoded CBFA2T3-GLIS2 fusion pr otein defines an aggressive subtype of pediatric acute megakaryoblastic leukemia . (PubMed id 23153540)1 Gruber T.A....Downing J.R. (2012)
    10. Identification of nuclear localization, DNA binding, and transactivating mechanisms of Kruppel-like zinc finger protein Gli-similar 2 (Glis2). (PubMed id 21127075)1 Vasanth S....Jetten A.M. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84662 HGNC: 29450 AceView: GLIS2 Ensembl:ENSG00000126603 euGenes: HUgn84662
    ECgene: GLIS2 H-InvDB: GLIS2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GLIS2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GLIS2 gene:
    Search GeneIP for patents involving GLIS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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