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Aliases for GLIS1 Gene

Aliases for GLIS1 Gene

  • GLIS Family Zinc Finger 1 2 3 5
  • GLI-Similar 1 4

External Ids for GLIS1 Gene

Previous GeneCards Identifiers for GLIS1 Gene

  • GC01M053683
  • GC01M053971
  • GC01M052086

Summaries for GLIS1 Gene

Entrez Gene Summary for GLIS1 Gene

  • GLIS1 is a GLI (MIM 165220)-related Kruppel-like zinc finger protein that functions as an activator and repressor of transcription (Kim et al., 2002 [PubMed 12042312]).[supplied by OMIM, Mar 2008]

GeneCards Summary for GLIS1 Gene

GLIS1 (GLIS Family Zinc Finger 1) is a Protein Coding gene. GO annotations related to this gene include RNA polymerase II regulatory region sequence-specific DNA binding and transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding. An important paralog of this gene is GLIS3.

UniProtKB/Swiss-Prot for GLIS1 Gene

  • Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5-GACCACCCAC-3 (By similarity).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLIS1 Gene

Genomics for GLIS1 Gene

Regulatory Elements for GLIS1 Gene

Enhancers for GLIS1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G053730 1.6 Ensembl ENCODE dbSUPER 13.3 +1.8 1782 10.9 FOXA2 PKNOX1 CREB3L1 ARNT ZFP64 ARID4B SIN3A DMAP1 FEZF1 ZNF2 MAGOH GLIS1 RNU7-95P ENSG00000201003 PODN ENSG00000230953 CYB5RL
GH01G053765 1.1 Ensembl ENCODE 10.2 -28.3 -28325 2.3 ATF1 FOXA2 PKNOX1 ZBTB40 EGR1 GATA2 FOS CREM ZBTB11 TBX21 GLIS1 NDC1 RPL37P7 HSPB11 LRRC42 YIPF1 ENSG00000201003 GC01M053772
GH01G053807 1 ENCODE 10.5 -70.0 -70001 0.7 HDGF ATF1 PKNOX1 FEZF1 ZNF2 YY1 TCF12 GLIS2 FOS KLF13 HSPB11 GLIS1 NDC1 ENSG00000201003 GC01M053772
GH01G053697 0.8 ENCODE 8.5 +40.0 40004 0.9 PKNOX1 TAL1 ZMYM3 ZIC2 RELA SCRT2 ZNF600 ZNF263 L3MBTL2 MTA2 GLIS1 RNU7-95P
GH01G053617 0.6 ENCODE 10.2 +120.6 120554 1.1 CTCF ATF3 POLR2A SMARCA4 BHLHE40 FOS NFE2L2 RNU7-95P GLIS1 GC01M053591 PIR52518 PIR51865
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GLIS1 on UCSC Golden Path with GeneCards custom track

Promoters for GLIS1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000006561 -1094 801 PKNOX1 RB1 SIN3A SCRT2 FOS EGR2 NFYA NFYC GATAD2B SP1

Genomic Location for GLIS1 Gene

Chromosome:
1
Start:
53,506,233 bp from pter
End:
53,738,106 bp from pter
Size:
231,874 bases
Orientation:
Minus strand

Genomic View for GLIS1 Gene

Genes around GLIS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GLIS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GLIS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLIS1 Gene

Proteins for GLIS1 Gene

  • Protein details for GLIS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NBF1-GLIS1_HUMAN
    Recommended name:
    Zinc finger protein GLIS1
    Protein Accession:
    Q8NBF1
    Secondary Accessions:
    • Q2M3G9
    • Q8N9V9

    Protein attributes for GLIS1 Gene

    Size:
    620 amino acids
    Molecular mass:
    65976 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC04178.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for GLIS1 Gene

Post-translational modifications for GLIS1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GLIS1 Gene

No data available for DME Specific Peptides for GLIS1 Gene

Domains & Families for GLIS1 Gene

Gene Families for GLIS1 Gene

Protein Domains for GLIS1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GLIS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NBF1

UniProtKB/Swiss-Prot:

GLIS1_HUMAN :
  • Belongs to the GLI C2H2-type zinc-finger protein family.
Family:
  • Belongs to the GLI C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with GLIS1: view

Function for GLIS1 Gene

Molecular function for GLIS1 Gene

UniProtKB/Swiss-Prot Function:
Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5-GACCACCCAC-3 (By similarity).

Gene Ontology (GO) - Molecular Function for GLIS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA --
GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding IEA --
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with GLIS1: view
genes like me logo Genes that share phenotypes with GLIS1: view

Animal Models for GLIS1 Gene

MGI Knock Outs for GLIS1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GLIS1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GLIS1 Gene

Localization for GLIS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLIS1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GLIS1 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for GLIS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS,IEA --
genes like me logo Genes that share ontologies with GLIS1: view

Pathways & Interactions for GLIS1 Gene

SuperPathways for GLIS1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GLIS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0006366 transcription from RNA polymerase II promoter ISS --
genes like me logo Genes that share ontologies with GLIS1: view

No data available for Pathways by source and SIGNOR curated interactions for GLIS1 Gene

Drugs & Compounds for GLIS1 Gene

No Compound Related Data Available

Transcripts for GLIS1 Gene

mRNA/cDNA for GLIS1 Gene

(6) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GLIS1 Gene

GLIS family zinc finger 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GLIS1

Alternative Splicing Database (ASD) splice patterns (SP) for GLIS1 Gene

No ASD Table

Relevant External Links for GLIS1 Gene

GeneLoc Exon Structure for
GLIS1
ECgene alternative splicing isoforms for
GLIS1

Expression for GLIS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GLIS1 Gene

mRNA differential expression in normal tissues according to GTEx for GLIS1 Gene

This gene is overexpressed in Prostate (x5.9) and Cervix - Endocervix (x4.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GLIS1 Gene



Protein tissue co-expression partners for GLIS1 Gene

NURSA nuclear receptor signaling pathways regulating expression of GLIS1 Gene:

GLIS1

SOURCE GeneReport for Unigene cluster for GLIS1 Gene:

Hs.306691

Evidence on tissue expression from TISSUES for GLIS1 Gene

  • Lung(4.2)
genes like me logo Genes that share expression patterns with GLIS1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GLIS1 Gene

Orthologs for GLIS1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GLIS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GLIS1 34 35
  • 98.39 (n)
cow
(Bos Taurus)
Mammalia GLIS1 34 35
  • 88.6 (n)
dog
(Canis familiaris)
Mammalia GLIS1 34 35
  • 88.15 (n)
rat
(Rattus norvegicus)
Mammalia Glis1 34
  • 83.98 (n)
mouse
(Mus musculus)
Mammalia Glis1 34 16 35
  • 83.12 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GLIS1 35
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves GLIS1 34 35
  • 64.13 (n)
lizard
(Anolis carolinensis)
Reptilia GLIS1 35
  • 64 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC100333406 34
  • 65.01 (n)
glis1b 35
  • 33 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta lmd 35
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ztf-14 35
  • 20 (a)
ManyToMany
tra-1 35
  • 13 (a)
ManyToMany
Species where no ortholog for GLIS1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GLIS1 Gene

ENSEMBL:
Gene Tree for GLIS1 (if available)
TreeFam:
Gene Tree for GLIS1 (if available)

Paralogs for GLIS1 Gene

genes like me logo Genes that share paralogs with GLIS1: view

Variants for GLIS1 Gene

Sequence variations from dbSNP and Humsavar for GLIS1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000002087 -- 53,736,533(+) CAGCG(C/T)TCCTC intron-variant
rs1000005714 -- 53,569,852(+) AAAGC(A/G/T)TAAGA intron-variant
rs1000033342 -- 53,736,309(+) GTACA(-/C)AAAGC intron-variant
rs1000037210 -- 53,718,342(+) CGGAA(C/T)TGAGG intron-variant
rs1000065933 -- 53,605,408(+) ATGGT(G/T)CTTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GLIS1 Gene

Variant ID Type Subtype PubMed ID
esv1769487 CNV insertion 17803354
esv2313944 CNV deletion 18987734
esv2670230 CNV deletion 23128226
esv2748286 CNV deletion 23290073
esv2748297 CNV deletion 23290073
esv2758936 CNV loss 17122850
esv3394793 CNV duplication 20981092
esv3586069 CNV loss 21293372
esv3586070 CNV loss 21293372
esv3586072 CNV loss 21293372
esv3586074 CNV loss 21293372
nsv1011262 CNV gain 25217958
nsv10162 CNV loss 18304495
nsv1113118 CNV deletion 24896259
nsv1132287 CNV duplication 24896259
nsv1141745 CNV insertion 24896259
nsv1144375 CNV deletion 24896259
nsv1153760 CNV duplication 26484159
nsv428443 CNV gain 18775914
nsv461494 CNV loss 19166990
nsv461506 CNV loss 19166990
nsv473585 CNV novel sequence insertion 20440878
nsv474645 CNV novel sequence insertion 20440878
nsv478320 CNV novel sequence insertion 20440878
nsv509269 CNV insertion 20534489
nsv509280 CNV insertion 20534489
nsv512739 CNV insertion 21212237
nsv522165 CNV loss 19592680
nsv527806 CNV loss 19592680
nsv546258 CNV loss 21841781
nsv546259 CNV loss 21841781
nsv829882 CNV loss 17160897
nsv888 CNV deletion 18451855
nsv899 CNV insertion 18451855

Variation tolerance for GLIS1 Gene

Residual Variation Intolerance Score: 80.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.15; 80.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GLIS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GLIS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLIS1 Gene

Disorders for GLIS1 Gene

Relevant External Links for GLIS1

Genetic Association Database (GAD)
GLIS1
Human Genome Epidemiology (HuGE) Navigator
GLIS1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GLIS1

No disorders were found for GLIS1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GLIS1 Gene

Publications for GLIS1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Genome-wide association of lipid-lowering response to statins in combined study populations. (PMID: 20339536) Barber M.J. … Krauss R.M. (PLoS ONE 2010) 3 46 64
  3. Regulatory role for KrA1ppel-like zinc-finger protein Gli-similar 1 (Glis1) in PMA-treated and psoriatic epidermis. (PMID: 16417217) Nakanishi G. … Jetten A.M. (J. Invest. Dermatol. 2006) 3 22 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. GLIS3, a novel member of the GLIS subfamily of Kruppel-like zinc finger proteins with repressor and activation functions. (PMID: 14500813) Kim Y.-S. … Jetten A.M. (Nucleic Acids Res. 2003) 2 3 64

Products for GLIS1 Gene

  • Addgene plasmids for GLIS1

Sources for GLIS1 Gene

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