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Aliases for GLIS1 Gene

Aliases for GLIS1 Gene

  • GLIS Family Zinc Finger 1 2 3 5
  • GLI-Similar 1 4

External Ids for GLIS1 Gene

Previous GeneCards Identifiers for GLIS1 Gene

  • GC01M053683
  • GC01M053971
  • GC01M052086

Summaries for GLIS1 Gene

Entrez Gene Summary for GLIS1 Gene

  • GLIS1 is a GLI (MIM 165220)-related Kruppel-like zinc finger protein that functions as an activator and repressor of transcription (Kim et al., 2002 [PubMed 12042312]).[supplied by OMIM, Mar 2008]

GeneCards Summary for GLIS1 Gene

GLIS1 (GLIS Family Zinc Finger 1) is a Protein Coding gene. GO annotations related to this gene include RNA polymerase II regulatory region sequence-specific DNA binding and transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding. An important paralog of this gene is ZIC3.

UniProtKB/Swiss-Prot for GLIS1 Gene

  • Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5-GACCACCCAC-3 (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLIS1 Gene

Genomics for GLIS1 Gene

Regulatory Elements for GLIS1 Gene

Enhancers for GLIS1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GLIS1 on UCSC Golden Path with GeneCards custom track

Promoters for GLIS1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GLIS1 on UCSC Golden Path with GeneCards custom track

Genomic Location for GLIS1 Gene

Chromosome:
1
Start:
53,506,233 bp from pter
End:
53,738,106 bp from pter
Size:
231,874 bases
Orientation:
Minus strand

Genomic View for GLIS1 Gene

Genes around GLIS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GLIS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GLIS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLIS1 Gene

Proteins for GLIS1 Gene

  • Protein details for GLIS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NBF1-GLIS1_HUMAN
    Recommended name:
    Zinc finger protein GLIS1
    Protein Accession:
    Q8NBF1
    Secondary Accessions:
    • Q2M3G9
    • Q8N9V9

    Protein attributes for GLIS1 Gene

    Size:
    620 amino acids
    Molecular mass:
    65976 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC04178.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for GLIS1 Gene

Proteomics data for GLIS1 Gene at MOPED

Post-translational modifications for GLIS1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GLIS1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for GLIS1

No data available for DME Specific Peptides for GLIS1 Gene

Domains & Families for GLIS1 Gene

Gene Families for GLIS1 Gene

Protein Domains for GLIS1 Gene

Suggested Antigen Peptide Sequences for GLIS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NBF1

UniProtKB/Swiss-Prot:

GLIS1_HUMAN :
  • Belongs to the GLI C2H2-type zinc-finger protein family.
  • Contains 5 C2H2-type zinc fingers.
Family:
  • Belongs to the GLI C2H2-type zinc-finger protein family.
Similarity:
  • Contains 5 C2H2-type zinc fingers.
genes like me logo Genes that share domains with GLIS1: view

Function for GLIS1 Gene

Molecular function for GLIS1 Gene

UniProtKB/Swiss-Prot Function:
Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5-GACCACCCAC-3 (By similarity).

Gene Ontology (GO) - Molecular Function for GLIS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with GLIS1: view
genes like me logo Genes that share phenotypes with GLIS1: view

Animal Models for GLIS1 Gene

MGI Knock Outs for GLIS1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GLIS1 Gene

Localization for GLIS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLIS1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GLIS1 Gene COMPARTMENTS Subcellular localization image for GLIS1 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for GLIS1 Gene

Pathways & Interactions for GLIS1 Gene

SuperPathways for GLIS1 Gene

No Data Available

Interacting Proteins for GLIS1 Gene

Gene Ontology (GO) - Biological Process for GLIS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045893 positive regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with GLIS1: view

No data available for Pathways by source and SIGNOR curated interactions for GLIS1 Gene

Drugs & Compounds for GLIS1 Gene

No Compound Related Data Available

Transcripts for GLIS1 Gene

mRNA/cDNA for GLIS1 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GLIS1 Gene

GLIS family zinc finger 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GLIS1 Gene

No ASD Table

Relevant External Links for GLIS1 Gene

GeneLoc Exon Structure for
GLIS1
ECgene alternative splicing isoforms for
GLIS1

Expression for GLIS1 Gene

mRNA expression in normal human tissues for GLIS1 Gene

mRNA differential expression in normal tissues according to GTEx for GLIS1 Gene

This gene is overexpressed in Prostate (x5.9) and Cervix - Endocervix (x4.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GLIS1 Gene



SOURCE GeneReport for Unigene cluster for GLIS1 Gene Hs.306691

genes like me logo Genes that share expression patterns with GLIS1: view

Protein tissue co-expression partners for GLIS1 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GLIS1 Gene

Orthologs for GLIS1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GLIS1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GLIS1 35
  • 88.6 (n)
  • 89.52 (a)
GLIS1 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GLIS1 35
  • 88.15 (n)
  • 88.37 (a)
GLIS1 36
  • 65 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Glis1 35
  • 83.12 (n)
  • 82.52 (a)
Glis1 16
Glis1 36
  • 65 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GLIS1 35
  • 98.39 (n)
  • 98.06 (a)
GLIS1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Glis1 35
  • 83.98 (n)
  • 83.66 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia GLIS1 36
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves GLIS1 35
  • 64.13 (n)
  • 65.22 (a)
GLIS1 36
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GLIS1 36
  • 64 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC100333406 35
  • 65.01 (n)
  • 62.63 (a)
glis1b 36
  • 33 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta lmd 36
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tra-1 36
  • 13 (a)
ManyToMany
ztf-14 36
  • 20 (a)
ManyToMany
Species with no ortholog for GLIS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GLIS1 Gene

ENSEMBL:
Gene Tree for GLIS1 (if available)
TreeFam:
Gene Tree for GLIS1 (if available)

Paralogs for GLIS1 Gene

genes like me logo Genes that share paralogs with GLIS1: view

Variants for GLIS1 Gene

Sequence variations from dbSNP and Humsavar for GLIS1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs34961060 - 53,594,434(-) AGCTC(C/T)TTGGG reference, missense
rs4307514 - 53,594,575(+) TCCCG(C/T)CAGAG reference, missense
rs35227000 - 53,594,343(-) CCTGG(C/G)AGGCA reference, missense
rs475322 -- 53,509,763(-) CTAGT(A/G/T)GGGGA intron-variant
rs481452 -- 53,532,074(-) GGCCT(C/T)TGAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GLIS1 Gene

Variant ID Type Subtype PubMed ID
nsv509269 CNV Insertion 20534489
nsv871730 CNV Loss 21882294
nsv829882 CNV Loss 17160897
dgv227n71 CNV Loss 21882294
dgv52e1 CNV Complex 17122850
nsv428443 CNV Gain 18775914
nsv888 CNV Loss 18451855
dgv228n71 CNV Loss 21882294
nsv527806 CNV Loss 19592680
nsv522165 CNV Loss 19592680
nsv512739 CNV Insertion 21212237
esv2670230 CNV Deletion 23128226
nsv10162 CNV Loss 18304495
nsv870751 CNV Loss 21882294
esv2748286 CNV Deletion 23290073
nsv899 CNV Insertion 18451855
nsv509280 CNV Insertion 20534489
nsv461494 CNV Loss 19166990
nsv461506 CNV Loss 19166990
esv2748297 CNV Deletion 23290073
esv2313944 CNV Deletion 18987734
esv1769487 CNV Insertion 17803354

Variation tolerance for GLIS1 Gene

Residual Variation Intolerance Score: 80.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.15; 80.74% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GLIS1 Gene

Disorders for GLIS1 Gene

Relevant External Links for GLIS1

Genetic Association Database (GAD)
GLIS1
Human Genome Epidemiology (HuGE) Navigator
GLIS1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GLIS1

No disorders were found for GLIS1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GLIS1 Gene

Publications for GLIS1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. Regulatory role for KrA1ppel-like zinc-finger protein Gli-similar 1 (Glis1) in PMA-treated and psoriatic epidermis. (PMID: 16417217) Nakanishi G. … Jetten A.M. (J. Invest. Dermatol. 2006) 3 23
  3. GLIS3, a novel member of the GLIS subfamily of Kruppel-like zinc finger proteins with repressor and activation functions. (PMID: 14500813) Kim Y.-S. … Jetten A.M. (Nucleic Acids Res. 2003) 2 3
  4. Identification of Glis1, a novel Gli-related, Kruppel-like zinc finger protein containing transactivation and repressor functions. (PMID: 12042312) Kim Y.S. … Jetten A.M. (J. Biol. Chem. 2002) 2 3
  5. A genome-wide association study of behavioral disinhibition. (PMID: 23942779) McGue M. … Iacono W.G. (Behav. Genet. 2013) 3

Products for GLIS1 Gene

Sources for GLIS1 Gene

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