Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



GLIS1 Gene

protein-coding   GIFtS: 50
GCID: GC01M053971

GLIS Family Zinc Finger 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
GLIS Family Zinc Finger 11 2
GLI-Similar 12 3
Zinc Finger Protein GLIS12

External Ids:    HGNC: 295251   Entrez Gene: 1489792   Ensembl: ENSG000001743327   OMIM: 6103785   UniProtKB: Q8NBF13   

Export aliases for GLIS1 gene to outside databases

Previous GC identifers: GC01M053683 GC01M052086


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for GLIS1 Gene:
GLIS1 is a GLI (MIM 165220)-related Kruppel-like zinc finger protein that functions as an activator and repressor
of transcription (Kim et al., 2002 (PubMed 12042312)).(supplied by OMIM, Mar 2008)

GeneCards Summary for GLIS1 Gene:
GLIS1 (GLIS family zinc finger 1) is a protein-coding gene. Diseases associated with GLIS1 include nephronophthisis, and parkinson's disease. An important paralog of this gene is MTF1.

UniProtKB/Swiss-Prot: GLIS1_HUMAN, Q8NBF1
Function: Acts as both a repressor and activator of transcription. Binds to the consensus sequence
5'-GACCACCCAC-3' (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for GLIS1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGLIS1 promoter sequence
   Search Chromatin IP Primers for GLIS1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GLIS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p32.3   Ensembl cytogenetic band:  1p32.3   HGNC cytogenetic band: 1p32.3

GLIS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GLIS1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M053971:  view genomic region     (about GC identifiers)

Start:
53,971,906 bp from pter      End:
54,199,877 bp from pter
Size:
227,972 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: GLIS1_HUMAN, Q8NBF1 (See protein sequence)
Recommended Name: Zinc finger protein GLIS1  
Size: 620 amino acids; 65976 Da
Sequence caution: Sequence=BAC04178.1; Type=Erroneous initiation;
Secondary accessions: Q2M3G9 Q8N9V9

Explore the universe of human proteins at neXtProt for GLIS1: NX_Q8NBF1

Explore proteomics data for GLIS1 at MOPED


See GLIS1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_671726.2  
ENSEMBL proteins: 
 ENSP00000309653  

GLIS1 Human Recombinant Protein Products:

Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate for GLIS1
OriGene Custom MassSpec
OriGene Custom Protein Services for GLIS1
GenScript Custom Purified and Recombinant Proteins Services for GLIS1
Novus Biologicals GLIS1 Lysate
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for GLIS1

GLIS1 Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
R&D Systems Antibodies for GLIS1
OriGene Antibodies for GLIS1
OriGene Custom Antibody Services for GLIS1
Novus Biologicals GLIS1 Antibodies
Abcam antibodies for GLIS1
Cloud-Clone Corp. Antibodies for GLIS1
ThermoFisher Antibodies for GLIS1
LSBio Antibodies in human, mouse, rat for GLIS1

GLIS1 Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for GLIS1
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for GLIS1
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for GLIS1
Cloud-Clone Corp. CLIAs for GLIS1


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus
HGNC Gene Families:
ZNF: Zinc fingers, C2H2-type

3 InterPro protein domains:
 IPR015880 Znf_C2H2-like
 IPR013087 Znf_C2H2/integrase_DNA-bd
 IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q8NBF1

ProtoNet protein and cluster: Q8NBF1

UniProtKB/Swiss-Prot: GLIS1_HUMAN, Q8NBF1
Similarity: Belongs to the GLI C2H2-type zinc-finger protein family
Similarity: Contains 5 C2H2-type zinc fingers


GLIS1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

     UniProtKB/Swiss-Prot Summary: GLIS1_HUMAN, Q8NBF1
Function: Acts as both a repressor and activator of transcription. Binds to the consensus sequence
5'-GACCACCCAC-3' (By similarity)

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003677DNA binding IEA--
GO:0046872metal ion binding IEA--
     
GLIS1 for ontologies           About GeneDecksing


Phenotypes:
     2 GenomeRNAi human phenotypes for GLIS1:
 Actin fiber cells  Increased cell number in S 

     3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Glis1):
 limbs/digits/tail  nervous system  normal 

GLIS1 for phenotypes           About GeneDecksing

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GLIS1
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GLIS1

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GLIS1
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GLIS1

miRNA
Products:
    
Block miRNA regulation of human, mouse, rat GLIS1 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate GLIS1 (see all 14):
hsa-miR-3163 hsa-miR-4307 hsa-miR-4328 hsa-miR-409-3p hsa-miR-548e hsa-miR-578 hsa-miR-548o hsa-miR-548aa
SwitchGear 3'UTR luciferase reporter plasmidGLIS1 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for GLIS1
Predesigned siRNA for gene silencing in human, mouse, rat GLIS1

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for GLIS1

Clone
Products:
     
OriGene clones in human, mouse for GLIS1 (see all 6)
OriGene ORF clones in mouse, rat for GLIS1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: GLIS1 (NM_147193)
Sino Biological Human cDNA Clone for GLIS1
DNA2.0 Custom Codon Optimized Gene Synthesis Service for GLIS1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GLIS1

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for GLIS1
Browse ESI BIO Cell Lines and PureStem Progenitors for GLIS1 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GLIS1


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot
GLIS1_HUMAN, Q8NBF1: Nucleus (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus4
cytosol1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus ISS--

GLIS1 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus




    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GLIS1
Interactions:

    Search GeneGlobe Interaction Network for GLIS1

Gene Ontology (GO): 5 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000122negative regulation of transcription from RNA polymerase II promoter ISS--
GO:0006357regulation of transcription from RNA polymerase II promoter ----
GO:0006366transcription from RNA polymerase II promoter ISS--
GO:0045893positive regulation of transcription, DNA-templated ----
GO:0045944positive regulation of transcription from RNA polymerase II promoter ISS--

GLIS1 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus
Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for GLIS1



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for GLIS1 gene: 
NM_147193.2  

Unigene Cluster for GLIS1:

GLIS family zinc finger 1
Hs.306691  [show with all ESTs]
Unigene Representative Sequence: NM_147193
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000312233(uc001cvr.1)
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat GLIS1 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate GLIS1 (see all 14):
hsa-miR-3163 hsa-miR-4307 hsa-miR-4328 hsa-miR-409-3p hsa-miR-548e hsa-miR-578 hsa-miR-548o hsa-miR-548aa
SwitchGear 3'UTR luciferase reporter plasmidGLIS1 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for GLIS1
Predesigned siRNA for gene silencing in human, mouse, rat GLIS1
Clone
Products:
     
OriGene clones in human, mouse for GLIS1 (see all 6)
OriGene ORF clones in mouse, rat for GLIS1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: GLIS1 (NM_147193)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for GLIS1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GLIS1
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for GLIS1
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GLIS1
  QuantiTect SYBR Green Assays in human, mouse, rat GLIS1
  QuantiFast Probe-based Assays in human, mouse, rat GLIS1

Additional mRNA sequence: 

AK090634.1 AK093474.1 BC101799.1 BC104911.1 

1 DOTS entry:

DT.100012675 

15 AceView cDNA sequences:

AX748150 AK093474 BQ005715 BX354528 BX283392 NM_147193 AK090634 BX116059 
AA872588 BG747839 AX746550 BX354527 N47961 AI762232 N49172 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

GLIS1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ACCCAGGGGA
GLIS1 Expression
About this image

GLIS1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

GLIS1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.306691
    Custom PCR Arrays for GLIS1
Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for GLIS1
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GLIS1
QuantiTect SYBR Green Assays in human, mouse, rat GLIS1
QuantiFast Probe-based Assays in human, mouse, rat GLIS1
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GLIS1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of animals.

Orthologs for GLIS1 gene from Selected species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Glis11 , 5 GLIS family zinc finger 11, 5 83.12(n)1
82.52(a)1
  4 (50.18 cM)5
2305871  NM_147221.21  NP_671754.21 
 1074345915 
chicken
(Gallus gallus)
Aves GLIS11 GLIS family zinc finger 1 64.13(n)
65.22(a)
  424652  XM_422485.4  XP_422485.4 
lizard
(Anolis carolinensis)
Reptilia GLIS16
GLIS family zinc finger 1
64(a)
1 ↔ 1
4(115519993-115665673)
zebrafish
(Danio rerio)
Actinopterygii LOC1003334061 zinc finger protein GLIS1-like 65.01(n)
62.63(a)
  100333406  XM_002663103.3  XP_002663149.2 
fruit fly
(Drosophila melanogaster)
Insecta lmd6
lame duck
21(a)
1 → many
3R(18846944-18852435)
worm
(Caenorhabditis elegans)
Secernentea ztf-146
tra-16
Protein TRA-1, isoform a
20(a)
13(a)
many ↔ many
many ↔ many
X(14496085-14499434) WBGene00010936
III(11172092-11195207) WBGene00006604


ENSEMBL Gene Tree for GLIS1 (if available)
TreeFam Gene Tree for GLIS1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section

TryGeneCards Plus
Paralogs for GLIS1 gene
MTF12  ZIC32  ZNF4102  ZNF762  GLI12  ZIC22  ZIC12  GLIS22  
GLI22  ZIC42  ZNF1432  GLIS32  ZIC52  GLI32  
Selected SIMAP similar genes for GLIS1 using alignment to 1 protein entry:     GLIS1_HUMAN(see all similar genes):
GLIS3    kr-znf3    DKFZp686N0199    HZF16    ZNF    ZNF78L1
ZFS-5    ZNF808    DKFZp686O1631    ZNF323    ZSCAN21    DKFZp666C237
PLZF    ZFS-2    ZNF600    ZNF22    ZNF72    A-328A3.4

GLIS1 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

Selected SNPs for GLIS1 (see all 4600)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1890013191,2
--53971426(+) AGCCTA/TTGCCC 1 -- ds50010--------
rs1817208981,2
--53971492(+) GTTTTC/TTCTGT 1 -- ds50010--------
rs1841524351,2
--53971541(+) CCACCC/TGCTGA 1 -- ds50010--------
rs1448174971,2
--53971581(+) TCAGAC/TGGAGC 1 -- ds50010--------
rs1164860571,2
F--53971639(+) TCGCCG/ACACCC 1 -- ds50011Minor allele frequency- A:0.03WA 118
rs1160963681,2
F--53971697(+) CTGCAC/TAGTCC 1 -- ds50011Minor allele frequency- T:0.01WA 118
rs115863601,2
H--53971743(+) CATGGT/GGGGGG 1 -- ds50014Minor allele frequency- G:0.00NS EA 414
rs171086421,2
C,F,H--53971807(+) TTCTAC/TGCAGC 1 -- ds500114Minor allele frequency- T:0.08NA NS EA WA 1328
rs120850161,2
C,F,H--53971910(+) TCACAT/CCTCCT 1 -- ut31 trp313Minor allele frequency- C:0.05EA NS NA WA 1386
rs728933081,2
C--53971972(+) GGGAAC/TGGAAA 1 -- ut312Minor allele frequency- T:0.09WA 120

HapMap Linkage Disequilibrium report for GLIS1 (53971906 - 54199877 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for GLIS1 (see all 22):    About this table    
Variant IDTypeSubtypePubMed ID
esv2748286CNV Deletion23290073
esv2748297CNV Deletion23290073
esv2670230CNV Deletion23128226
esv2313944CNV Deletion18987734
esv1769487CNV Insertion17803354
nsv899CNV Insertion18451855
nsv509280CNV Insertion20534489
nsv509269CNV Insertion20534489
nsv512739CNV Insertion21212237
nsv10162CNV Loss18304495

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing GLIS1
DNA2.0 Custom Variant and Variant Library Synthesis for GLIS1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus
OMIM gene information: 610378    OMIM disorders: --

3 diseases for GLIS1:    
About MalaCards
nephronophthisis    parkinson's disease    endotheliitis

1 disease from the University of Copenhagen DISEASES database for GLIS1:
Nephronophthisis

GLIS1 for disorders           About GeneDecksing

Genetic Association Database (GAD): GLIS1
Human Genome Epidemiology (HuGE) Navigator: GLIS1 (1 document)

Export disorders for GLIS1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for GLIS1 gene, integrated from 10 sources (see all 15):
(articles sorted by number of sources associating them with GLIS1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
  2. Genome-wide association of lipid-lowering response to statins in combined study populations. (PubMed id 20339536)1, 4 Barber M.J....Krauss R.M. (PLoS ONE 2010)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  4. GLIS3, a novel member of the GLIS subfamily of Kruppel-like zinc finger proteins with repressor and activation functions. (PubMed id 14500813)1, 3 Kim Y.-S.... Jetten A.M. (Nucleic Acids Res. 2003)
  5. Identification of Glis1, a novel Gli-related, Kruppel-like zinc finger protein containing transactivation and repressor functions. (PubMed id 12042312)1, 3 Kim Y.S....Jetten A.M. (J. Biol. Chem. 2002)
  6. Regulatory role for KrA1ppel-like zinc-finger protein Gli-similar 1 (Glis1) in PMA-treated and psoriatic epidermis. (PubMed id 16417217)1, 9 Nakanishi G....Jetten A.M. (J. Invest. Dermatol. 2006)
  7. A genome-wide association study of behavioral disinhibition. (PubMed id 23942779)1 McGue M....Iacono W.G. (Behav. Genet. 2013)
  8. The KrA1ppel-like zinc finger transcription factor, GLI-similar 1, is regulated by hypoxia-inducible factors via non-canonical mechanisms. (PubMed id 24383088)1 Khalesi E....Tanimoto K. (Biochem. Biophys. Res. Commun. 2013)
  9. GLIS1 rs797906: an increased risk factor for late-onset Parkinson's disease in the Han Chinese population. (PubMed id 22759478)1 Song W....Shang H.F. (Eur. Neurol. 2012)
  10. Direct reprogramming of somatic cells is promoted by maternal transcription factor Glis1. (PubMed id 21654807)1 Maekawa M....Yamanaka S. (Nature 2011)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus
Entrez Gene: 148979 HGNC: 29525 AceView: GLIS1 Ensembl:ENSG00000174332 euGenes: HUgn148979
ECgene: GLIS1 H-InvDB: GLIS1

(According to HUGE)
About This Section

TryGeneCards Plus
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus
NameDescription
PharmGKB entry for GLIS1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section

TryGeneCards Plus
Patent Information for GLIS1 gene:
Search GeneIP for patents involving GLIS1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

TryGeneCards Plus

 
 EMD Millipore genomic analysis products

  
 Antibodies for GLIS1 (Glis1)   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
 Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 OriGene Antibodies for GLIS1   OriGene RNAi products in human, mouse, rat for GLIS1  
 Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for GLIS1  
 OriGene Custom Mass Spec   OriGene clones in human, mouse for GLIS1  
 OriGene qSTAR qPCR primer pairs in human, mouse for GLIS1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
 OriGene ORF clones in mouse, rat for GLIS1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for GLIS1   OriGene Custom Protein Services for GLIS1  

 
 
 Block miRNA regulation of human, mouse, rat GLIS1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing GLIS1
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GLIS1 Predesigned siRNA for gene silencing in human, mouse, rat GLIS1
 QuantiFast Probe-based Assays in human, mouse, rat GLIS1 QuantiTect SYBR Green Assays in human, mouse, rat GLIS1
 Custom PCR Arrays for GLIS1 Search Chromatin IP Primers for GLIS1
 Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GLIS1  Search GeneGlobe Interaction Network for GLIS1
 Search Regulatory tfbs for GLIS1
 GenScript Custom Purified and Recombinant Proteins Services for GLIS1 GenScript cDNA clones with any tag delivered in your preferred vector for GLIS1
 GenScript Custom Assay Services for GLIS1 GenScript Custom overexpressing Cell Line Services for GLIS1
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
 Search for Antibodies & Assays

 Search Tocris compounds for GLIS1
 Browse Sino Biological Proteins
 Browse Sino Biological Cell Lysates
 cDNA Clones for GLIS1
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 GLIS1 antibodies
 GLIS1 lysates
 Antibodies for GLIS1
 See all of Abcam's Antibodies, Kits and Proteins for GLIS1
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins
 Proteins for GLIS1
 Antibodies for GLIS1
 ELISAs for GLIS1
 CLIAs for GLIS1



 Browse ESI BIO Cell Lines and PureStem Progenitors for GLIS1
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GLIS1
 SwitchGear 3'UTR luciferase reporter plasmids for GLIS1
 SwitchGear Promoter luciferase reporter plasmids for GLIS1
 ThermoFisher Antibodies for GLIS1
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GLIS1
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GLIS1
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GLIS1
 LSBio Antibodies in human, mouse, rat for GLIS1
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
 Browse compounds at ApexBio
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

View Random Gene

Category
(GIFtS: )
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      GLIS1 gene at Home site.
Version: 3.12.166 28 Aug 2014
hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4