Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GLIS1 Gene

Aliases for GLIS1 Gene

  • GLIS Family Zinc Finger 1 2 3
  • GLI-Similar 1 4

External Ids for GLIS1 Gene

Previous GeneCards Identifiers for GLIS1 Gene

  • GC01M053683
  • GC01M053971
  • GC01M052086

Summaries for GLIS1 Gene

Entrez Gene Summary for GLIS1 Gene

  • GLIS1 is a GLI (MIM 165220)-related Kruppel-like zinc finger protein that functions as an activator and repressor of transcription (Kim et al., 2002 [PubMed 12042312]).[supplied by OMIM, Mar 2008]

GeneCards Summary for GLIS1 Gene

GLIS1 (GLIS Family Zinc Finger 1) is a Protein Coding gene. An important paralog of this gene is ZIC4.

UniProtKB/Swiss-Prot for GLIS1 Gene

  • Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5-GACCACCCAC-3 (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLIS1 Gene

Genomics for GLIS1 Gene

Genomic Location for GLIS1 Gene

Start:
53,506,231 bp from pter
End:
53,738,075 bp from pter
Size:
231,845 bases
Orientation:
Minus strand

Genomic View for GLIS1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GLIS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLIS1 Gene

No data available for Regulatory Elements for GLIS1 Gene

Proteins for GLIS1 Gene

  • Protein details for GLIS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NBF1-GLIS1_HUMAN
    Recommended name:
    Zinc finger protein GLIS1
    Protein Accession:
    Q8NBF1
    Secondary Accessions:
    • Q2M3G9
    • Q8N9V9

    Protein attributes for GLIS1 Gene

    Size:
    620 amino acids
    Molecular mass:
    65976 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC04178.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for GLIS1 Gene

Proteomics data for GLIS1 Gene at MOPED

Post-translational modifications for GLIS1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GLIS1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GLIS1 Gene

Domains for GLIS1 Gene

Gene Families for GLIS1 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for GLIS1 Gene

Suggested Antigen Peptide Sequences for GLIS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NBF1

UniProtKB/Swiss-Prot:

GLIS1_HUMAN :
  • Q8NBF1
Family:
  • Belongs to the GLI C2H2-type zinc-finger protein family.
Similarity:
  • Contains 5 C2H2-type zinc fingers.
genes like me logo Genes that share domains with GLIS1: view

Function for GLIS1 Gene

Molecular function for GLIS1 Gene

UniProtKB/Swiss-Prot Function: Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5-GACCACCCAC-3 (By similarity).

Gene Ontology (GO) - Molecular Function for GLIS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA --
GO:0001227 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IEA --
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA --
GO:0003677 DNA binding --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with GLIS1: view

Phenotypes for GLIS1 Gene

genes like me logo Genes that share phenotypes with GLIS1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for GLIS1 Gene

Localization for GLIS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLIS1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GLIS1 Gene COMPARTMENTS Subcellular localization image for GLIS1 gene
Compartment Confidence
nucleus 4
cytosol 1

Gene Ontology (GO) - Cellular Components for GLIS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
genes like me logo Genes that share ontologies with GLIS1: view

Pathways for GLIS1 Gene

SuperPathways for GLIS1 Gene

No Data Available

Interacting Proteins for GLIS1 Gene

Gene Ontology (GO) - Biological Process for GLIS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS --
GO:0006357 regulation of transcription from RNA polymerase II promoter --
GO:0006366 transcription from RNA polymerase II promoter ISS --
GO:0045893 positive regulation of transcription, DNA-templated --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter ISS --
genes like me logo Genes that share ontologies with GLIS1: view

No data available for Pathways by source for GLIS1 Gene

Transcripts for GLIS1 Gene

mRNA/cDNA for GLIS1 Gene

(15) Selected AceView cDNA sequences:
(4) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GLIS1 Gene

GLIS family zinc finger 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GLIS1 Gene

No ASD Table

Relevant External Links for GLIS1 Gene

GeneLoc Exon Structure for
GLIS1
ECgene alternative splicing isoforms for
GLIS1

Expression for GLIS1 Gene

mRNA expression in normal human tissues for GLIS1 Gene

mRNA differential expression in normal tissues according to GTEx for GLIS1 Gene

This gene is overexpressed in Prostate (5.9) and Cervix - Endocervix (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for GLIS1 Gene

SOURCE GeneReport for Unigene cluster for GLIS1 Gene Hs.306691

genes like me logo Genes that share expressions with GLIS1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for GLIS1 Gene

Orthologs for GLIS1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GLIS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GLIS1 35
  • 98.39 (n)
  • 98.06 (a)
GLIS1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GLIS1 35
  • 88.6 (n)
  • 89.52 (a)
GLIS1 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GLIS1 35
  • 88.15 (n)
  • 88.37 (a)
GLIS1 36
  • 65 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Glis1 35
  • 83.12 (n)
  • 82.52 (a)
Glis1 16
Glis1 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GLIS1 36
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Glis1 35
  • 83.98 (n)
  • 83.66 (a)
chicken
(Gallus gallus)
Aves GLIS1 35
  • 64.13 (n)
  • 65.22 (a)
GLIS1 36
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GLIS1 36
  • 64 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii glis1b 36
  • 33 (a)
OneToOne
LOC100333406 35
  • 65.01 (n)
  • 62.63 (a)
fruit fly
(Drosophila melanogaster)
Insecta lmd 36
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tra-1 36
  • 13 (a)
ManyToMany
ztf-14 36
  • 20 (a)
ManyToMany
Species with no ortholog for GLIS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GLIS1 Gene

ENSEMBL:
Gene Tree for GLIS1 (if available)
TreeFam:
Gene Tree for GLIS1 (if available)

Paralogs for GLIS1 Gene

Paralogs for GLIS1 Gene

genes like me logo Genes that share paralogs with GLIS1: view

Variants for GLIS1 Gene

Sequence variations from dbSNP and Humsavar for GLIS1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs475322 -- 53,509,763(-) CTAGT(G/T)GGGGA intron-variant
rs481452 -- 53,532,074(-) GGCCT(C/T)TGAGC intron-variant
rs489050 -- 53,553,800(+) TGTAA(A/G)GGCCT intron-variant
rs490537 -- 53,560,053(+) cagga(C/T)tagag intron-variant
rs490654 -- 53,522,044(-) TGGGC(A/T)TGCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GLIS1 Gene

Variant ID Type Subtype PubMed ID
nsv509269 CNV Insertion 20534489
nsv871730 CNV Loss 21882294
nsv829882 CNV Loss 17160897
dgv227n71 CNV Loss 21882294
dgv52e1 CNV Complex 17122850
nsv428443 CNV Gain 18775914
nsv888 CNV Loss 18451855
dgv228n71 CNV Loss 21882294
nsv527806 CNV Loss 19592680
nsv522165 CNV Loss 19592680
nsv512739 CNV Insertion 21212237
esv2670230 CNV Deletion 23128226
nsv10162 CNV Loss 18304495
nsv870751 CNV Loss 21882294
esv2748286 CNV Deletion 23290073
nsv899 CNV Insertion 18451855
nsv509280 CNV Insertion 20534489
nsv461494 CNV Loss 19166990
nsv461506 CNV Loss 19166990
esv2748297 CNV Deletion 23290073
esv2313944 CNV Deletion 18987734
esv1769487 CNV Insertion 17803354

Relevant External Links for GLIS1 Gene

HapMap Linkage Disequilibrium report
GLIS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLIS1 Gene

Disorders for GLIS1 Gene

(1) University of Copenhagen DISEASES for GLIS1 Gene

Relevant External Links for GLIS1

Genetic Association Database (GAD)
GLIS1
Human Genome Epidemiology (HuGE) Navigator
GLIS1
genes like me logo Genes that share disorders with GLIS1: view

No data available for UniProtKB/Swiss-Prot for GLIS1 Gene

Publications for GLIS1 Gene

  1. Genome-wide association of lipid-lowering response to statins in combined study populations. (PMID: 20339536) Barber M.J. … Krauss R.M. (PLoS ONE 2010) 3 48
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  3. Regulatory role for KrA1ppel-like zinc-finger protein Gli-similar 1 (Glis1) in PMA-treated and psoriatic epidermis. (PMID: 16417217) Nakanishi G. … Jetten A.M. (J. Invest. Dermatol. 2006) 3 23
  4. Identification of Glis1, a novel Gli-related, Kruppel-like zinc finger protein containing transactivation and repressor functions. (PMID: 12042312) Kim Y.S. … Jetten A.M. (J. Biol. Chem. 2002) 2 3
  5. GLIS3, a novel member of the GLIS subfamily of Kruppel-like zinc finger proteins with repressor and activation functions. (PMID: 14500813) Kim Y.-S. … Jetten A.M. (Nucleic Acids Res. 2003) 2 3

Products for GLIS1 Gene

  • Addgene plasmids for GLIS1

Sources for GLIS1 Gene

Back to Top

Content