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Aliases for GLIPR2 Gene

Aliases for GLIPR2 Gene

  • GLI Pathogenesis Related 2 2 3 5
  • Glioma Pathogenesis-Related Protein 2 3 4
  • Golgi-Associated PR-1 Protein 3 4
  • GliPR 2 3 4
  • C9orf19 3 4
  • GAPR-1 3 4
  • GAPR1 3 4
  • Golgi-Associated Plant Pathogenesis-Related Protein 1 3
  • Chromosome 9 Open Reading Frame 19 2
  • GLI Pathogenesis-Related 2 2
  • 17kD Fetal Brain Protein 3

External Ids for GLIPR2 Gene

Previous HGNC Symbols for GLIPR2 Gene

  • C9orf19

Summaries for GLIPR2 Gene

GeneCards Summary for GLIPR2 Gene

GLIPR2 (GLI Pathogenesis Related 2) is a Protein Coding gene. GO annotations related to this gene include protein homodimerization activity.

Additional gene information for GLIPR2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLIPR2 Gene

Genomics for GLIPR2 Gene

Regulatory Elements for GLIPR2 Gene

Enhancers for GLIPR2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09H036150 1.7 FANTOM5 Ensembl ENCODE dbSUPER 18.7 +16.4 16448 5 ELF3 BATF RARA ATF7 ETV6 RUNX3 CREM IKZF2 MIXL1 CBFB GLIPR2 GNE HMGB3P24 OR2S2 TLN1 OR13J1 CCIN
GH09H036138 1.5 FANTOM5 ENCODE dbSUPER 20.2 +5.7 5738 7 TBP PKNOX1 FOXA2 PTBP1 YBX1 RAD21 TCF12 GATA2 ZNF366 RUNX3 GLIPR2 CCIN CLTA HMGB3P24
GH09H035904 1.8 FANTOM5 Ensembl ENCODE dbSUPER 9.5 -228.4 -228369 7 FOXA2 YY1 ZNF121 ZNF143 FOS DEK SP3 REST PPARG ZNF518A HRCT1 SPAAR TMEM8B PIGO OR13J1 FAM221B NDUFA5P4 ENSG00000227388 NPR2 FANCG
GH09H035913 1.5 Ensembl ENCODE dbSUPER 9.8 -219.3 -219295 7 HDGF ATF1 ARNT ARID4B YBX1 ZBTB7B YY1 TCF12 ZNF766 ELK1 PIGO ARHGEF39 RGP1 TLN1 GBA2 SPAAR CLTA RECK NDUFA5P4 OR13J1
GH09H036099 1.1 Ensembl ENCODE 13 -34.7 -34725 4 HDAC1 RB1 RAD21 RFX5 TCF12 ZNF143 RCOR1 FOS RUNX3 ZNF654 CCIN GLIPR2 RECK ENSG00000276730
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GLIPR2 on UCSC Golden Path with GeneCards custom track

Promoters for GLIPR2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000234747 264 1201 TBP CTCF MXI1 KLF1 SIN3A RAD21 ZIC2 E2F1 GLIS2 CTBP1

Genomic Location for GLIPR2 Gene

Chromosome:
9
Start:
36,136,536 bp from pter
End:
36,163,913 bp from pter
Size:
27,378 bases
Orientation:
Plus strand

Genomic View for GLIPR2 Gene

Genes around GLIPR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GLIPR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GLIPR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLIPR2 Gene

Proteins for GLIPR2 Gene

  • Protein details for GLIPR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H4G4-GAPR1_HUMAN
    Recommended name:
    Golgi-associated plant pathogenesis-related protein 1
    Protein Accession:
    Q9H4G4
    Secondary Accessions:
    • Q5VZR1
    • Q8N2S6
    • Q8WWC9
    • Q8WX36

    Protein attributes for GLIPR2 Gene

    Size:
    154 amino acids
    Molecular mass:
    17218 Da
    Quaternary structure:
    • Homodimer. Interacts with CAV1.

    Three dimensional structures from OCA and Proteopedia for GLIPR2 Gene

neXtProt entry for GLIPR2 Gene

Post-translational modifications for GLIPR2 Gene

  • Ubiquitination at posLast=1515 and isoforms=88
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GLIPR2 Gene

Domains & Families for GLIPR2 Gene

Gene Families for GLIPR2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for GLIPR2 Gene

Suggested Antigen Peptide Sequences for GLIPR2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H4G4

UniProtKB/Swiss-Prot:

GAPR1_HUMAN :
  • Belongs to the CRISP family.
Family:
  • Belongs to the CRISP family.
genes like me logo Genes that share domains with GLIPR2: view

Function for GLIPR2 Gene

Phenotypes From GWAS Catalog for GLIPR2 Gene

Gene Ontology (GO) - Molecular Function for GLIPR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042803 protein homodimerization activity IDA 15123429
genes like me logo Genes that share ontologies with GLIPR2: view
genes like me logo Genes that share phenotypes with GLIPR2: view

Animal Model Products

CRISPR Products

miRNA for GLIPR2 Gene

miRTarBase miRNAs that target GLIPR2

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for GLIPR2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GLIPR2 Gene

Localization for GLIPR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLIPR2 Gene

Golgi apparatus membrane; Lipid-anchor. Note=Binds lipid-enriched microdomains of Golgi membranes not only by ionic interactions but also through the myristate.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GLIPR2 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
cytoskeleton 2
nucleus 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Microtubules (1)
  • Vesicles (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GLIPR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IDA 11865038
GO:0005576 extracellular region IEA --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0070062 extracellular exosome IDA 18570454
genes like me logo Genes that share ontologies with GLIPR2: view

Pathways & Interactions for GLIPR2 Gene

SuperPathways for GLIPR2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GLIPR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010634 positive regulation of epithelial cell migration IDA 23516513
GO:0010718 positive regulation of epithelial to mesenchymal transition IDA 23516513
GO:0070374 positive regulation of ERK1 and ERK2 cascade IDA 23516513
genes like me logo Genes that share ontologies with GLIPR2: view

No data available for Pathways by source and SIGNOR curated interactions for GLIPR2 Gene

Drugs & Compounds for GLIPR2 Gene

(1) Drugs for GLIPR2 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cysteinesulfonic Acid Experimental Pharma Target 0
genes like me logo Genes that share compounds with GLIPR2: view

Transcripts for GLIPR2 Gene

Unigene Clusters for GLIPR2 Gene

GLI pathogenesis-related 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for GLIPR2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for GLIPR2 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d · 10e
SP1: - -
SP2: - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - -
SP7: - - - - - - - - - - - - - - - -
SP8: -
SP9: - - - - - - - - -
SP10: - - - - - - - - - - -
SP11: - - - - - -
SP12: - - - - - - - - - - - - -
SP13: -

Relevant External Links for GLIPR2 Gene

GeneLoc Exon Structure for
GLIPR2
ECgene alternative splicing isoforms for
GLIPR2

Expression for GLIPR2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GLIPR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GLIPR2 Gene

This gene is overexpressed in Whole Blood (x15.3).

Protein differential expression in normal tissues from HIPED for GLIPR2 Gene

This gene is overexpressed in Nasal epithelium (8.9) and Serum (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GLIPR2 Gene



Protein tissue co-expression partners for GLIPR2 Gene

NURSA nuclear receptor signaling pathways regulating expression of GLIPR2 Gene:

GLIPR2

SOURCE GeneReport for Unigene cluster for GLIPR2 Gene:

Hs.493819

mRNA Expression by UniProt/SwissProt for GLIPR2 Gene:

Q9H4G4-GAPR1_HUMAN
Tissue specificity: Highest expression in lung and peripheral leukocytes, and minor expression in liver and kidney.

Evidence on tissue expression from TISSUES for GLIPR2 Gene

  • Nervous system(4.8)
  • Blood(2.2)
genes like me logo Genes that share expression patterns with GLIPR2: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GLIPR2 Gene

Orthologs for GLIPR2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GLIPR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GLIPR2 33 34
  • 98.89 (n)
dog
(Canis familiaris)
Mammalia GLIPR2 34 33
  • 91.78 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GLIPR2 34 33
  • 90.57 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Glipr2 33
  • 88.6 (n)
mouse
(Mus musculus)
Mammalia Glipr2 16 34 33
  • 88.16 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GLIPR2 34
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GLIPR2 34
  • 20 (a)
OneToOne
chicken
(Gallus gallus)
Aves GLIPR2 34 33
  • 74.12 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GLIPR2 34
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia glipr2 33
  • 59.34 (n)
zebrafish
(Danio rerio)
Actinopterygii glipr2l 33 34
  • 68.65 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007584 33
  • 53.96 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG31482 34
  • 34 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F09B9.5 34
  • 29 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRY1 34
  • 20 (a)
OneToMany
PRY2 34
  • 16 (a)
OneToMany
PRY3 34 36
  • 7 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 27 (a)
OneToOne
Species where no ortholog for GLIPR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GLIPR2 Gene

ENSEMBL:
Gene Tree for GLIPR2 (if available)
TreeFam:
Gene Tree for GLIPR2 (if available)

Paralogs for GLIPR2 Gene

(1) SIMAP similar genes for GLIPR2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GLIPR2: view

No data available for Paralogs for GLIPR2 Gene

Variants for GLIPR2 Gene

Sequence variations from dbSNP and Humsavar for GLIPR2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000286593 -- 36,145,248(+) TGCTC(A/C)GTGTC intron-variant
rs1000293579 -- 36,149,341(+) AGCCT(C/T)ACATT intron-variant
rs1000324246 -- 36,157,060(+) TGCCC(A/G)GGCTG intron-variant
rs1000409195 -- 36,149,620(+) CAGGT(C/T)CCTCC intron-variant
rs1000624272 -- 36,150,620(+) GGGAT(A/G)GGTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GLIPR2 Gene

Variant ID Type Subtype PubMed ID
esv34080 CNV loss 18971310
nsv1017711 CNV gain 25217958
nsv1125318 OTHER inversion 24896259
nsv519442 CNV loss 19592680
nsv527617 CNV gain 19592680
nsv528600 CNV loss 19592680
nsv831547 CNV loss 17160897

Variation tolerance for GLIPR2 Gene

Residual Variation Intolerance Score: 60.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.67; 14.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GLIPR2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GLIPR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLIPR2 Gene

Disorders for GLIPR2 Gene

Relevant External Links for GLIPR2

Genetic Association Database (GAD)
GLIPR2
Human Genome Epidemiology (HuGE) Navigator
GLIPR2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GLIPR2

No disorders were found for GLIPR2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GLIPR2 Gene

Publications for GLIPR2 Gene

  1. Identification and characterization of a novel human plant pathogenesis-related protein that localizes to lipid-enriched microdomains in the Golgi complex. (PMID: 11865038) Eberle HB … Helms JB (Journal of cell science 2002) 2 3 4 22 60
  2. Cloning and characterization of a human novel gene C9orf19 encoding a conserved putative protein with an SCP-like extracellular protein domain. (PMID: 12137952) Eisenberg I … Mitrani-Rosenbaum S (Gene 2002) 2 3 4 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. Structural analysis of the human Golgi-associated plant pathogenesis related protein GAPR-1 implicates dimerization as a regulatory mechanism. (PMID: 15123429) Serrano RL … Groves MR (Journal of molecular biology 2004) 3 4 60
  5. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 60

Products for GLIPR2 Gene

Sources for GLIPR2 Gene

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