Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GLIPR2 Gene

Aliases for GLIPR2 Gene

  • GLI Pathogenesis Related 2 2 3
  • GLI Pathogenesis-Related 2 2 3 5
  • Glioma Pathogenesis-Related Protein 2 3 4
  • Golgi-Associated PR-1 Protein 3 4
  • GliPR 2 3 4
  • C9orf19 3 4
  • GAPR-1 3 4
  • GAPR1 3 4
  • Chromosome 9 Open Reading Frame 19 2
  • 17kD Fetal Brain Protein 3

External Ids for GLIPR2 Gene

Previous HGNC Symbols for GLIPR2 Gene

  • C9orf19

Summaries for GLIPR2 Gene

GeneCards Summary for GLIPR2 Gene

GLIPR2 (GLI Pathogenesis Related 2) is a Protein Coding gene. GO annotations related to this gene include protein homodimerization activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLIPR2 Gene

Genomics for GLIPR2 Gene

Regulatory Elements for GLIPR2 Gene

Promoters for GLIPR2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GLIPR2 on UCSC Golden Path with GeneCards custom track

Genomic Location for GLIPR2 Gene

Chromosome:
9
Start:
36,136,536 bp from pter
End:
36,163,913 bp from pter
Size:
27,378 bases
Orientation:
Plus strand

Genomic View for GLIPR2 Gene

Genes around GLIPR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GLIPR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GLIPR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLIPR2 Gene

Proteins for GLIPR2 Gene

  • Protein details for GLIPR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H4G4-GAPR1_HUMAN
    Recommended name:
    Golgi-associated plant pathogenesis-related protein 1
    Protein Accession:
    Q9H4G4
    Secondary Accessions:
    • Q5VZR1
    • Q8N2S6
    • Q8WWC9
    • Q8WX36

    Protein attributes for GLIPR2 Gene

    Size:
    154 amino acids
    Molecular mass:
    17218 Da
    Quaternary structure:
    • Homodimer. Interacts with CAV1.

    Three dimensional structures from OCA and Proteopedia for GLIPR2 Gene

neXtProt entry for GLIPR2 Gene

Proteomics data for GLIPR2 Gene at MOPED

Post-translational modifications for GLIPR2 Gene

  • Ubiquitination at Lys 15 and Lys 88
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GLIPR2 Gene

Domains & Families for GLIPR2 Gene

Protein Domains for GLIPR2 Gene

Suggested Antigen Peptide Sequences for GLIPR2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H4G4

UniProtKB/Swiss-Prot:

GAPR1_HUMAN :
  • Contains 1 SCP domain.
  • Belongs to the CRISP family.
Domain:
  • Contains 1 SCP domain.
Family:
  • Belongs to the CRISP family.
genes like me logo Genes that share domains with GLIPR2: view

No data available for Gene Families for GLIPR2 Gene

Function for GLIPR2 Gene

genes like me logo Genes that share phenotypes with GLIPR2: view

Animal Model Products

miRNA for GLIPR2 Gene

miRTarBase miRNAs that target GLIPR2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GLIPR2 Gene

Localization for GLIPR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLIPR2 Gene

Golgi apparatus membrane; Lipid-anchor. Note=Binds lipid-enriched microdomains of Golgi membranes not only by ionic interactions but also through the myristate.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GLIPR2 Gene COMPARTMENTS Subcellular localization image for GLIPR2 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
cytoskeleton 2
cytosol 2
nucleus 2
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for GLIPR2 Gene

Pathways & Interactions for GLIPR2 Gene

SuperPathways for GLIPR2 Gene

No Data Available

Interacting Proteins for GLIPR2 Gene

Gene Ontology (GO) - Biological Process for GLIPR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010634 positive regulation of epithelial cell migration IDA 23516513
genes like me logo Genes that share ontologies with GLIPR2: view

No data available for Pathways by source and SIGNOR curated interactions for GLIPR2 Gene

Drugs & Compounds for GLIPR2 Gene

(1) Drugs for GLIPR2 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cysteinesulfonic Acid Experimental Pharma Target 0
genes like me logo Genes that share compounds with GLIPR2: view

Transcripts for GLIPR2 Gene

Unigene Clusters for GLIPR2 Gene

GLI pathogenesis-related 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GLIPR2 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d · 10e
SP1: - -
SP2: - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - -
SP7: - - - - - - - - - - - - - - - -
SP8: -
SP9: - - - - - - - - -
SP10: - - - - - - - - - - -
SP11: - - - - - -
SP12: - - - - - - - - - - - - -
SP13: -

Relevant External Links for GLIPR2 Gene

GeneLoc Exon Structure for
GLIPR2
ECgene alternative splicing isoforms for
GLIPR2

Expression for GLIPR2 Gene

mRNA expression in normal human tissues for GLIPR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GLIPR2 Gene

This gene is overexpressed in Whole Blood (x15.3).

Protein differential expression in normal tissues from HIPED for GLIPR2 Gene

This gene is overexpressed in Nasal epithelium (8.9) and Serum (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GLIPR2 Gene



SOURCE GeneReport for Unigene cluster for GLIPR2 Gene Hs.493819

mRNA Expression by UniProt/SwissProt for GLIPR2 Gene

Q9H4G4-GAPR1_HUMAN
Tissue specificity: Highest expression in lung and peripheral leukocytes, and minor expression in liver and kidney.
genes like me logo Genes that share expression patterns with GLIPR2: view

Protein tissue co-expression partners for GLIPR2 Gene

Primer Products

In Situ Assay Products

Orthologs for GLIPR2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GLIPR2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GLIPR2 35
  • 90.57 (n)
  • 95.39 (a)
GLIPR2 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GLIPR2 35
  • 91.78 (n)
  • 98 (a)
GLIPR2 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Glipr2 35
  • 88.16 (n)
  • 92.76 (a)
Glipr2 16
Glipr2 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GLIPR2 35
  • 98.89 (n)
  • 99.33 (a)
GLIPR2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Glipr2 35
  • 88.6 (n)
  • 93.42 (a)
oppossum
(Monodelphis domestica)
Mammalia GLIPR2 36
  • 20 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GLIPR2 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves GLIPR2 35
  • 74.12 (n)
  • 81.58 (a)
GLIPR2 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GLIPR2 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia glipr2 35
  • 59.34 (n)
  • 53.9 (a)
zebrafish
(Danio rerio)
Actinopterygii glipr2l 35
  • 68.65 (n)
  • 72.85 (a)
glipr2l 36
  • 73 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007584 35
  • 53.96 (n)
  • 46.76 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31482 36
  • 34 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F09B9.5 36
  • 29 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRY1 36
  • 20 (a)
OneToMany
PRY2 36
  • 16 (a)
OneToMany
PRY3 36
  • 7 (a)
OneToMany
PRY3 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
OneToOne
Species with no ortholog for GLIPR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GLIPR2 Gene

ENSEMBL:
Gene Tree for GLIPR2 (if available)
TreeFam:
Gene Tree for GLIPR2 (if available)

Paralogs for GLIPR2 Gene

(1) SIMAP similar genes for GLIPR2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GLIPR2: view

No data available for Paralogs for GLIPR2 Gene

Variants for GLIPR2 Gene

Sequence variations from dbSNP and Humsavar for GLIPR2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs6610 -- 36,163,566(+) GTTCC(A/G)GGGAG nc-transcript-variant, utr-variant-3-prime
rs11281 -- 36,163,573(+) GGAGG(C/T)GGCCG nc-transcript-variant, utr-variant-3-prime
rs11588 -- 36,163,005(+) AAATA(C/T)AAAGC nc-transcript-variant, utr-variant-3-prime
rs14501 -- 36,163,639(-) CAGGG(G/T)AACCT nc-transcript-variant, utr-variant-3-prime
rs748216 -- 36,136,857(+) CGTCT(C/T)CCTCG intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for GLIPR2 Gene

Variant ID Type Subtype PubMed ID
nsv893049 CNV Gain 21882294
nsv831547 CNV Loss 17160897
esv34080 CNV Loss 18971310
nsv893050 CNV Loss 21882294
nsv527617 CNV Gain 19592680
nsv519442 CNV Loss 19592680
nsv528600 CNV Loss 19592680

Variation tolerance for GLIPR2 Gene

Residual Variation Intolerance Score: 60.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.67; 14.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GLIPR2 Gene

HapMap Linkage Disequilibrium report
GLIPR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLIPR2 Gene

Disorders for GLIPR2 Gene

Relevant External Links for GLIPR2

Genetic Association Database (GAD)
GLIPR2
Human Genome Epidemiology (HuGE) Navigator
GLIPR2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GLIPR2

No disorders were found for GLIPR2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GLIPR2 Gene

Publications for GLIPR2 Gene

  1. Identification and characterization of a novel human plant pathogenesis-related protein that localizes to lipid-enriched microdomains in the Golgi complex. (PMID: 11865038) Eberle H.B. … Helms J.B. (J. Cell Sci. 2002) 2 3 4 23 67
  2. Cloning and characterization of a human novel gene C9orf19 encoding a conserved putative protein with an SCP-like extracellular protein domain. (PMID: 12137952) Eisenberg I. … Mitrani-Rosenbaum S. (Gene 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3

Products for GLIPR2 Gene

Sources for GLIPR2 Gene

Back to Top

Content