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Aliases for GLIPR2 Gene

Aliases for GLIPR2 Gene

  • GLI Pathogenesis Related 2 2 3 5
  • Glioma Pathogenesis-Related Protein 2 3 4
  • Golgi-Associated PR-1 Protein 3 4
  • GliPR 2 3 4
  • C9orf19 3 4
  • GAPR-1 3 4
  • GAPR1 3 4
  • Golgi-Associated Plant Pathogenesis-Related Protein 1 3
  • Chromosome 9 Open Reading Frame 19 2
  • GLI Pathogenesis-Related 2 2
  • 17kD Fetal Brain Protein 3

External Ids for GLIPR2 Gene

Previous HGNC Symbols for GLIPR2 Gene

  • C9orf19

Summaries for GLIPR2 Gene

GeneCards Summary for GLIPR2 Gene

GLIPR2 (GLI Pathogenesis Related 2) is a Protein Coding gene. GO annotations related to this gene include protein homodimerization activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLIPR2 Gene

Genomics for GLIPR2 Gene

Regulatory Elements for GLIPR2 Gene

Enhancers for GLIPR2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F036147 1.5 FANTOM5 Ensembl ENCODE 18.7 +15.1 15139 8.6 ELF3 SIN3A RAD21 ZNF48 ZBTB40 RARA EGR1 ETV6 FOS CREM GLIPR2 CLTA GNE HMGB3P24 OR2S2 TLN1 OR13J1 CCIN
GH09F035904 1.6 FANTOM5 Ensembl ENCODE 9.5 -228.4 -228436 7.8 SIN3A ZNF48 YY1 SLC30A9 ZNF121 GLIS2 FOS ZNF263 SP3 REST HRCT1 LINC00961 TMEM8B PIGO OR13J1 FAM221B NDUFA5P4 ENSG00000227388 NPR2 FANCG
GH09F036099 1.1 Ensembl ENCODE 13 -34.7 -34725 4.2 HDAC1 SIN3A RAD21 RFX5 RCOR1 FOS ZNF654 REST GLIS1 HMBOX1 CCIN GLIPR2 RECK ENSG00000276730
GH09F035913 1.3 Ensembl ENCODE 9.8 -219.4 -219386 7.9 HDGF PKNOX1 ATF1 ARNT ARID4B YBX1 ZNF48 YY1 ZNF766 ELK1 CREB3 SPAG8 YBX1P10 GBA2 LINC00961 RECK NDUFA5P4 FAM221B OR13J1 TMEM8B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GLIPR2 on UCSC Golden Path with GeneCards custom track

Promoters for GLIPR2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001302970 464 2001 TBP KLF17 SIN3A ZNF335 GLIS2 ZNF263 SP3 REST GLIS1 ZNF341
ENSR00001908617 1764 201 PRDM1

Genomic Location for GLIPR2 Gene

36,136,536 bp from pter
36,163,913 bp from pter
27,378 bases
Plus strand

Genomic View for GLIPR2 Gene

Genes around GLIPR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GLIPR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GLIPR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLIPR2 Gene

Proteins for GLIPR2 Gene

  • Protein details for GLIPR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Golgi-associated plant pathogenesis-related protein 1
    Protein Accession:
    Secondary Accessions:
    • Q5VZR1
    • Q8N2S6
    • Q8WWC9
    • Q8WX36

    Protein attributes for GLIPR2 Gene

    154 amino acids
    Molecular mass:
    17218 Da
    Quaternary structure:
    • Homodimer. Interacts with CAV1.

    Three dimensional structures from OCA and Proteopedia for GLIPR2 Gene

neXtProt entry for GLIPR2 Gene

Post-translational modifications for GLIPR2 Gene

  • Ubiquitination at Lys 15 and Lys 88
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GLIPR2 Gene

Domains & Families for GLIPR2 Gene

Protein Domains for GLIPR2 Gene

Suggested Antigen Peptide Sequences for GLIPR2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 SCP domain.
  • Belongs to the CRISP family.
  • Contains 1 SCP domain.
  • Belongs to the CRISP family.
genes like me logo Genes that share domains with GLIPR2: view

No data available for Gene Families for GLIPR2 Gene

Function for GLIPR2 Gene

Gene Ontology (GO) - Molecular Function for GLIPR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042803 protein homodimerization activity IDA 15123429
genes like me logo Genes that share ontologies with GLIPR2: view
genes like me logo Genes that share phenotypes with GLIPR2: view

Animal Model Products

miRNA for GLIPR2 Gene

miRTarBase miRNAs that target GLIPR2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GLIPR2 Gene

Localization for GLIPR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLIPR2 Gene

Golgi apparatus membrane; Lipid-anchor. Note=Binds lipid-enriched microdomains of Golgi membranes not only by ionic interactions but also through the myristate.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GLIPR2 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
cytoskeleton 2
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for GLIPR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IDA 11865038
GO:0005576 extracellular region IEA --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0070062 extracellular exosome IDA 18570454
genes like me logo Genes that share ontologies with GLIPR2: view

Pathways & Interactions for GLIPR2 Gene

SuperPathways for GLIPR2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GLIPR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010634 positive regulation of epithelial cell migration IDA 23516513
GO:0010718 positive regulation of epithelial to mesenchymal transition IDA 23516513
GO:0070374 positive regulation of ERK1 and ERK2 cascade IDA 23516513
genes like me logo Genes that share ontologies with GLIPR2: view

No data available for Pathways by source and SIGNOR curated interactions for GLIPR2 Gene

Drugs & Compounds for GLIPR2 Gene

(1) Drugs for GLIPR2 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cysteinesulfonic Acid Experimental Pharma Target 0
genes like me logo Genes that share compounds with GLIPR2: view

Transcripts for GLIPR2 Gene

Unigene Clusters for GLIPR2 Gene

GLI pathogenesis-related 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GLIPR2 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d · 10e
SP1: - -
SP2: - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - -
SP7: - - - - - - - - - - - - - - - -
SP8: -
SP9: - - - - - - - - -
SP10: - - - - - - - - - - -
SP11: - - - - - -
SP12: - - - - - - - - - - - - -
SP13: -

Relevant External Links for GLIPR2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GLIPR2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GLIPR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GLIPR2 Gene

This gene is overexpressed in Whole Blood (x15.3).

Protein differential expression in normal tissues from HIPED for GLIPR2 Gene

This gene is overexpressed in Nasal epithelium (8.9) and Serum (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GLIPR2 Gene

Protein tissue co-expression partners for GLIPR2 Gene

NURSA nuclear receptor signaling pathways regulating expression of GLIPR2 Gene:


SOURCE GeneReport for Unigene cluster for GLIPR2 Gene:


mRNA Expression by UniProt/SwissProt for GLIPR2 Gene:

Tissue specificity: Highest expression in lung and peripheral leukocytes, and minor expression in liver and kidney.
genes like me logo Genes that share expression patterns with GLIPR2: view

Primer Products

Orthologs for GLIPR2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GLIPR2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GLIPR2 34 35
  • 98.89 (n)
(Canis familiaris)
Mammalia GLIPR2 34 35
  • 91.78 (n)
(Bos Taurus)
Mammalia GLIPR2 34 35
  • 90.57 (n)
(Rattus norvegicus)
Mammalia Glipr2 34
  • 88.6 (n)
(Mus musculus)
Mammalia Glipr2 34 16 35
  • 88.16 (n)
(Ornithorhynchus anatinus)
Mammalia GLIPR2 35
  • 87 (a)
(Monodelphis domestica)
Mammalia GLIPR2 35
  • 20 (a)
(Gallus gallus)
Aves GLIPR2 34 35
  • 74.12 (n)
(Anolis carolinensis)
Reptilia GLIPR2 35
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia glipr2 34
  • 59.34 (n)
(Danio rerio)
Actinopterygii glipr2l 34 35
  • 68.65 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007584 34
  • 53.96 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG31482 35
  • 34 (a)
(Caenorhabditis elegans)
Secernentea F09B9.5 35
  • 29 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRY1 35
  • 20 (a)
PRY2 35
  • 16 (a)
PRY3 35 37
  • 7 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 27 (a)
Species where no ortholog for GLIPR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GLIPR2 Gene

Gene Tree for GLIPR2 (if available)
Gene Tree for GLIPR2 (if available)

Paralogs for GLIPR2 Gene

(1) SIMAP similar genes for GLIPR2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GLIPR2: view

No data available for Paralogs for GLIPR2 Gene

Variants for GLIPR2 Gene

Sequence variations from dbSNP and Humsavar for GLIPR2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10758347 -- 36,137,372(+) TCCTC(A/G)GAGTG intron-variant
rs10758348 -- 36,139,780(+) AAGAC(A/G)CTTGG intron-variant
rs10814334 -- 36,135,898(+) GACCA(C/T)ATCTC upstream-variant-2KB
rs10814335 -- 36,137,801(+) TCCAC(C/T)TCAGA intron-variant
rs10814336 -- 36,142,097(+) GTATG(C/G)TGGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GLIPR2 Gene

Variant ID Type Subtype PubMed ID
esv34080 CNV loss 18971310
nsv1017711 CNV gain 25217958
nsv1125318 OTHER inversion 24896259
nsv519442 CNV loss 19592680
nsv527617 CNV gain 19592680
nsv528600 CNV loss 19592680
nsv831547 CNV loss 17160897

Variation tolerance for GLIPR2 Gene

Residual Variation Intolerance Score: 60.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.67; 14.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GLIPR2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLIPR2 Gene

Disorders for GLIPR2 Gene

Relevant External Links for GLIPR2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GLIPR2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GLIPR2 Gene

Publications for GLIPR2 Gene

  1. Identification and characterization of a novel human plant pathogenesis-related protein that localizes to lipid-enriched microdomains in the Golgi complex. (PMID: 11865038) Eberle H.B. … Helms J.B. (J. Cell Sci. 2002) 2 3 4 22 64
  2. Cloning and characterization of a human novel gene C9orf19 encoding a conserved putative protein with an SCP-like extracellular protein domain. (PMID: 12137952) Eisenberg I. … Mitrani-Rosenbaum S. (Gene 2002) 2 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Structural analysis of the human Golgi-associated plant pathogenesis related protein GAPR-1 implicates dimerization as a regulatory mechanism. (PMID: 15123429) Serrano R.L. … Groves M.R. (J. Mol. Biol. 2004) 3 4 64
  5. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 64

Products for GLIPR2 Gene

Sources for GLIPR2 Gene

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