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GLIPR1L2 Gene

protein-coding   GIFtS: 45
GCID: GC12P075784

GLI Pathogenesis-Related 1 Like 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
GLI Pathogenesis-Related 1 Like 21 2
GLIPR1-Like Protein 22

External Ids:    HGNC: 285921   Entrez Gene: 1443212   Ensembl: ENSG000001804817   OMIM: 6103945   UniProtKB: Q4G1C93   

Export aliases for GLIPR1L2 gene to outside databases

Previous GC identifers: GC12P074072 GC12P072834


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GLIPR1L2 Gene:
This gene encodes a member of the cysteine-rich secretory protein, antigen 5, and pathogenesis-related 1
superfamily. Members of this family have roles in a variety of processes, including cancer and immune defense.
This gene is located in a cluster with two related genes on chromosome 12. Alternative splicing results in
multiple transcript variants. (provided by RefSeq, Jul 2012)

GeneCards Summary for GLIPR1L2 Gene:
GLIPR1L2 (GLI pathogenesis-related 1 like 2) is a protein-coding gene. Diseases associated with GLIPR1L2 include multiple myeloma, and myeloma. An important paralog of this gene is CLEC18B.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NC_018923.2  NT_029419.13  
Regulatory elements:
   Search for regulatory transcription factor binding sites for GLIPR1L2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGLIPR1L2 promoter sequence
   Search Chromatin IP Primers for GLIPR1L2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GLIPR1L2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q21.2   Ensembl cytogenetic band:  12q21.2   HGNC cytogenetic band: 12q21.1

GLIPR1L2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GLIPR1L2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P075784:  view genomic region     (about GC identifiers)

Start:
75,784,850 bp from pter      End:
75,826,468 bp from pter
Size:
41,619 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GRPL2_HUMAN, Q4G1C9 (See protein sequence)
Recommended Name: GLIPR1-like protein 2  
Size: 344 amino acids; 40179 Da
Sequence caution: Sequence=AAH16749.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=BAC04085.1; Type=Erroneous termination; Positions=230; Note=Translated as Gln;
Sequence=CAE45957.1; Type=Erroneous initiation;
Secondary accessions: Q6MZS1 Q8N6N0 Q8NA43
Alternative splicing: 6 isoforms:  Q4G1C9-1   Q4G1C9-2   Q4G1C9-3   Q4G1C9-4   Q4G1C9-5   Q4G1C9-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for GLIPR1L2: NX_Q4G1C9

Explore proteomics data for GLIPR1L2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See GLIPR1L2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001257325.1  NP_689649.1  

    ENSEMBL proteins: 
     ENSP00000448248   ENSP00000367963   ENSP00000317385   ENSP00000447980   ENSP00000398328  
     ENSP00000367960   ENSP00000405273  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR014044 CAP_domain
     IPR001283 Allrgn_V5/Tpx1

    Graphical View of Domain Structure for InterPro Entry Q4G1C9

    ProtoNet protein and cluster: Q4G1C9

    1 Blocks protein domain: IPB001283 Allergen V5/Tpx-1 related

    UniProtKB/Swiss-Prot: GRPL2_HUMAN, Q4G1C9
    Similarity: Belongs to the CRISP family
    Similarity: Contains 1 SCP domain


    GLIPR1L2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GRPL2_HUMAN, Q4G1C9
    Induction: Up-regulated by doxycycline

    Phenotypes:
         1 GenomeRNAi human phenotype for GLIPR1L2:

     Increased homologous recombina 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GLIPR1L2
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GRPL2_HUMAN, Q4G1C9: Membrane; Single-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    golgi apparatus2
    cytosol1
    lysosome1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    GLIPR1L2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GLIPR1L2
    Interactions:

        Search GeneGlobe Interaction Network for GLIPR1L2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for GLIPR1L2 (ENSP000003173854) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP1CAENSP000003260314STRING: ENSP00000326031
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GLIPR1L2 (GRPL2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for GLIPR1L2 gene (2 alternative transcripts): 
    NM_001270396.1  NM_152436.2  

    Unigene Cluster for GLIPR1L2:

    GLI pathogenesis-related 1 like 2
    Hs.406728  [show with all ESTs]
    Unigene Representative Sequence: NR_072995
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000550916(uc001sxr.1) ENST00000378692(uc001sxq.1) ENST00000320460(uc001sxp.1)
    ENST00000547164 ENST00000435775 ENST00000378689 ENST00000441218
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat GLIPR1L2
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    Additional mRNA sequence: 

    AK093175.1 BC016749.1 BC029557.1 BC032022.1 BX640916.1 NR_072995.1 

    3 DOTS entries:

    DT.40208089  DT.91736350  DT.101978441 

    Selected AceView cDNA sequences (see all 34):

    BC032022 BP378831 H97952 AA813702 BG717916 BC016749 BQ429166 BG214441 
    BX640916 AK093175 NM_152436 AX747973 BG718710 BI548529 BG204772 BG209722 
    BG214790 BG219504 BC029557 BG203265 BG722054 AV726710 BG201172 BQ429240 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GLIPR1L2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAATATTCC
    GLIPR1L2 Expression
    About this image


    GLIPR1L2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebellum
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    GLIPR1L2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GLIPR1L2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.406728

    UniProtKB/Swiss-Prot: GRPL2_HUMAN, Q4G1C9
    Tissue specificity: Highly expressed in testis. Detected in prostate, kidney, bladder, lung and bone marrow

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for GLIPR1L2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Glipr1l21 , 5 GLI pathogenesis-related 1 like 21, 5 71.08(n)1
    64.11(a)1
      10 (60.09 cM)5
    675371  NM_026223.21  NP_080499.11 
     1120833545 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    42(a)
    1 → many
    1(37704465-37713667)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    39(a)
    39(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    5(40336988-40343592)
    AAWZ02040943(2197-4963)
    African clawed frog
    (Xenopus laevis)
    Amphibia BG347093.12   -- 72.82(n)    BG347093.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CU694453.16
    glipr1b6
    GLI pathogenesis-related 1b
    36(a)
    31(a)
    many ↔ many
    many ↔ many
    4(2112690-2119781) ENSDARG00000045224
    18(6808792-6818600) ENSDARG00000030078
    worm
    (Caenorhabditis elegans)
    Secernentea scl-26
    scl-66
    (see all 19)
    Protein SCL-6 (scl-6) mRNA, complete cds
    (see all 19)
    24(a)
    23(a)
    (see all 19)
    many ↔ many
    many ↔ many
    (see all 19)
    IV(13057678-13059092) WBGene00009895
    IV(13068768-13070290) WBGene00008028


    ENSEMBL Gene Tree for GLIPR1L2 (if available)
    TreeFam Gene Tree for GLIPR1L2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GLIPR1L2 gene
    CLEC18B2  CRISPLD22  CLEC18C2  PI162  GLIPR12  CRISP22  PI152  CRISP12  
    CRISPLD12  CRISP32  GLIPR1L12  CLEC18A2  R3HDML2  
    2 SIMAP similar genes for GLIPR1L2 using alignment to 1 protein entry:     GRPL2_HUMAN:
    GLIPR1    GLIPR1L1

    GLIPR1L2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GLIPR1L2 (see all 834)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs347221181,2
    C,F--75783153(+) TGTCTA/GGCAGT 3 -- us2k19Minor allele frequency- G:0.20NA WA CSA EA 370
    rs1180744271,2
    F--75783427(+) TTCTAG/CCGTTT 3 -- us2k11Minor allele frequency- C:0.01NA 120
    rs1505564741,2
    --75783449(+) CTCCTA/TAGGCA 3 -- us2k10--------
    rs43918571,2
    C,F,A,H--75783542(+) CCCTGG/CTCCTC 3 -- us2k117Minor allele frequency- C:0.42NS EA NA WA CSA 792
    rs1396521371,2
    C--75783706(+) AGTCAC/TAGTAG 3 -- us2k10--------
    rs1497496441,2
    --75783778(+) CATCAC/TAGACA 3 -- us2k10--------
    rs748377131,2
    C,F--75783888(+) ATGCTA/GTTAAG 3 -- us2k11Minor allele frequency- G:0.03NA 120
    rs1846186441,2
    --75783906(+) TGTAAC/TATGCA 3 -- us2k10--------
    rs1899414091,2
    --75783932(+) ACTAAC/TACTTG 3 -- us2k10--------
    rs1807945021,2
    --75784015(+) TGTTTA/GGAGGT 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for GLIPR1L2 (75784850 - 75826468 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for GLIPR1L2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv899312CNV Loss21882294
    nsv899313CNV Gain21882294

    Human Gene Mutation Database (HGMD): GLIPR1L2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GLIPR1L2
    DNA2.0 Custom Variant and Variant Library Synthesis for GLIPR1L2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610394    OMIM disorders: --

    3 diseases for GLIPR1L2:    
    About MalaCards
    multiple myeloma    myeloma    prostatitis


    GLIPR1L2 for disorders           About GeneDecksing


    Export disorders for GLIPR1L2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GLIPR1L2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with GLIPR1L2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of RTVP1/GLIPR1-like genes, a novel p53 target gene cluster. (PubMed id 16714093)1, 2 Ren C.... Thompson T.C. (Genomics 2006)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    5. Protein phosphatase 1I+ interacting proteins in the human brain. (PubMed id 22321011)1 Esteves S.L....da Cruz e Silva E.F. (OMICS 2012)
    6. Examining Hedgehog pathway genes GLI3, SHH, and PTCH1 and the p53 target GLIPR1/GLIPR1L1/GLIPR1L2 gene cluster using fluorescence in situ hybridization uncovers GLIPR1/GLIPR1L1/GLIPR1L2 deletion in 9% of patients with multiple myeloma. (PubMed id 20978342)1 Tam M....Lennon P.A. (J Assoc Genet Technol 2010)
    7. The CAP superfamily: cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins--roles in reproduction, cancer, and immune defense. (PubMed id 18824526)1 Gibbs G.M....O'Bryan M.K. (Endocr. Rev. 2008)
    8. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    9. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (Nature 2006)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 144321 HGNC: 28592 AceView: MGC39497 Ensembl:ENSG00000180481 euGenes: HUgn144321
    ECgene: GLIPR1L2 H-InvDB: GLIPR1L2

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GLIPR1L2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GLIPR1L2 gene:
    Search GeneIP for patents involving GLIPR1L2

    GeneCards and IP:
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