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Aliases for GLIPR1L2 Gene

Aliases for GLIPR1L2 Gene

  • GLI Pathogenesis-Related 1 Like 2 2 3

External Ids for GLIPR1L2 Gene

Previous GeneCards Identifiers for GLIPR1L2 Gene

  • GC12P074072
  • GC12P075784
  • GC12P072834

Summaries for GLIPR1L2 Gene

Entrez Gene Summary for GLIPR1L2 Gene

  • This gene encodes a member of the cysteine-rich secretory protein, antigen 5, and pathogenesis-related 1 superfamily. Members of this family have roles in a variety of processes, including cancer and immune defense. This gene is located in a cluster with two related genes on chromosome 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

GeneCards Summary for GLIPR1L2 Gene

GLIPR1L2 (GLI Pathogenesis-Related 1 Like 2) is a Protein Coding gene. An important paralog of this gene is CLEC18B.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLIPR1L2 Gene

Genomics for GLIPR1L2 Gene

Genomic Location for GLIPR1L2 Gene

75,391,070 bp from pter
75,432,688 bp from pter
41,619 bases
Plus strand

Genomic View for GLIPR1L2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GLIPR1L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLIPR1L2 Gene

No data available for Regulatory Elements for GLIPR1L2 Gene

Proteins for GLIPR1L2 Gene

  • Protein details for GLIPR1L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    GLIPR1-like protein 2
    Protein Accession:
    Secondary Accessions:
    • Q6MZS1
    • Q8N6N0
    • Q8NA43

    Protein attributes for GLIPR1L2 Gene

    344 amino acids
    Molecular mass:
    40179 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH16749.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAC04085.1; Type=Erroneous termination; Positions=230; Note=Translated as Gln.; Evidence={ECO:0000305}; Sequence=CAE45957.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for GLIPR1L2 Gene

neXtProt entry for GLIPR1L2 Gene

Proteomics data for GLIPR1L2 Gene at MOPED

Post-translational modifications for GLIPR1L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GLIPR1L2 Gene

Antibody Products

No data available for DME Specific Peptides for GLIPR1L2 Gene

Domains for GLIPR1L2 Gene

Protein Domains for GLIPR1L2 Gene

Suggested Antigen Peptide Sequences for GLIPR1L2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q4G1C9
  • Contains 1 SCP domain.
  • Belongs to the CRISP family.
genes like me logo Genes that share domains with GLIPR1L2: view

No data available for Gene Families for GLIPR1L2 Gene

Function for GLIPR1L2 Gene

Molecular function for GLIPR1L2 Gene

UniProtKB/Swiss-Prot Induction:
Up-regulated by doxycycline.

Phenotypes for GLIPR1L2 Gene

GenomeRNAi human phenotypes for GLIPR1L2:
genes like me logo Genes that share phenotypes with GLIPR1L2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GLIPR1L2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for GLIPR1L2 Gene

Localization for GLIPR1L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLIPR1L2 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for GLIPR1L2 Gene COMPARTMENTS Subcellular localization image for GLIPR1L2 gene
Compartment Confidence
extracellular 3
golgi apparatus 2
cytosol 1
lysosome 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for GLIPR1L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GLIPR1L2: view

Pathways for GLIPR1L2 Gene

SuperPathways for GLIPR1L2 Gene

No Data Available

Interacting Proteins for GLIPR1L2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000317385 for GLIPR1L2 Gene via STRING

Gene Ontology (GO) - Biological Process for GLIPR1L2 Gene


No data available for Pathways by source for GLIPR1L2 Gene

Transcripts for GLIPR1L2 Gene

Unigene Clusters for GLIPR1L2 Gene

GLI pathogenesis-related 1 like 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GLIPR1L2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GLIPR1L2 Gene

No ASD Table

Relevant External Links for GLIPR1L2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GLIPR1L2 Gene

mRNA expression in normal human tissues for GLIPR1L2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GLIPR1L2 Gene

This gene is overexpressed in Testis (11.0).

SOURCE GeneReport for Unigene cluster for GLIPR1L2 Gene Hs.406728

mRNA Expression by UniProt/SwissProt for GLIPR1L2 Gene

Tissue specificity: Highly expressed in testis. Detected in prostate, kidney, bladder, lung and bone marrow.
genes like me logo Genes that share expressions with GLIPR1L2: view

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Expression partners for GLIPR1L2 Gene

Orthologs for GLIPR1L2 Gene

This gene was present in the common ancestor of animals.

Orthologs for GLIPR1L2 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia GLIPR1L2 35
  • 80.6 (n)
  • 68.23 (a)
  • 59 (a)
(Mus musculus)
Mammalia Glipr1l2 35
  • 71.08 (n)
  • 64.11 (a)
Glipr1l2 16
Glipr1l2 36
  • 63 (a)
(Pan troglodytes)
Mammalia GLIPR1L2 35
  • 98.4 (n)
  • 97.25 (a)
  • 97 (a)
(Rattus norvegicus)
Mammalia Glipr1l2 35
  • 73.93 (n)
  • 67.13 (a)
(Bos Taurus)
Mammalia GLIPR1L2 36
  • 66 (a)
(Monodelphis domestica)
Mammalia GLIPR1L2 36
  • 41 (a)
(Gallus gallus)
Aves -- 36
  • 42 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 37 (a)
-- 36
  • 39 (a)
-- 36
  • 39 (a)
(Danio rerio)
Actinopterygii CU694453.1 36
  • 36 (a)
glipr1b 36
  • 31 (a)
(Caenorhabditis elegans)
Secernentea scl-1 36
  • 21 (a)
scl-10 36
  • 22 (a)
scl-11 36
  • 22 (a)
scl-12 36
  • 23 (a)
scl-13 36
  • 22 (a)
scl-14 36
  • 21 (a)
scl-15 36
  • 21 (a)
scl-17 36
  • 20 (a)
scl-18 36
  • 20 (a)
scl-19 36
  • 22 (a)
scl-2 36
  • 24 (a)
scl-20 36
  • 20 (a)
scl-21 36
  • 23 (a)
scl-3 36
  • 23 (a)
scl-5 36
  • 22 (a)
scl-6 36
  • 23 (a)
scl-7 36
  • 21 (a)
scl-8 36
  • 20 (a)
scl-9 36
  • 21 (a)
Species with no ortholog for GLIPR1L2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GLIPR1L2 Gene

Gene Tree for GLIPR1L2 (if available)
Gene Tree for GLIPR1L2 (if available)

Paralogs for GLIPR1L2 Gene

Selected SIMAP similar genes for GLIPR1L2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GLIPR1L2: view

Variants for GLIPR1L2 Gene

Sequence variations from dbSNP and Humsavar for GLIPR1L2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1543946 -- 75,422,832(-) ATATA(C/G)TTACT intron-variant
rs1875469 -- 75,432,490(+) TTCTA(A/T)AGCTA downstream-variant-500B
rs1909968 -- 75,417,231(+) AGAGG(A/G)GGATT intron-variant
rs1909969 -- 75,417,454(+) GCCAC(C/T)GAATT intron-variant
rs1909970 -- 75,417,520(+) CAGAC(C/T)TGGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GLIPR1L2 Gene

Variant ID Type Subtype PubMed ID
nsv899312 CNV Loss 21882294
nsv899313 CNV Gain 21882294

Relevant External Links for GLIPR1L2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLIPR1L2 Gene

Disorders for GLIPR1L2 Gene

No disorders were found for GLIPR1L2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for GLIPR1L2 Gene

Publications for GLIPR1L2 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Identification and characterization of RTVP1/GLIPR1-like genes, a novel p53 target gene cluster. (PMID: 16714093) Ren C. … Thompson T.C. (Genomics 2006) 3 4
  4. The CAP superfamily: cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins--roles in reproduction, cancer, and immune defense. (PMID: 18824526) Gibbs G.M. … O'Bryan M.K. (Endocr. Rev. 2008) 3
  5. Examining Hedgehog pathway genes GLI3, SHH, and PTCH1 and the p53 target GLIPR1/GLIPR1L1/GLIPR1L2 gene cluster using fluorescence in situ hybridization uncovers GLIPR1/GLIPR1L1/GLIPR1L2 deletion in 9% of patients with multiple myeloma. (PMID: 20978342) Tam M. … Lennon P.A. (J Assoc Genet Technol 2010) 3

Products for GLIPR1L2 Gene

Sources for GLIPR1L2 Gene

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