GLIPR1L2 Gene
protein-coding GIFtS: 41
GCID: GC12P075784
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GLI pathogenesis-related 1 like 2
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Aliases
for GLIPR1L2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| GLI Pathogenesis-Related 1 Like 21 2 | | MGC394971 | | GLIPR1-Like Protein 22 |
Export aliases for GLIPR1L2 gene to outside databasesPrevious GC identifers: GC12P074072 GC12P072834 |
Summaries
for GLIPR1L2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for GLIPR1L2:
This gene encodes a member of the cysteine-rich secretory protein, antigen 5, and pathogenesis-related 1 superfamily.Members of this family have roles in a variety of processes, including cancer and immune defense. This gene is locatedin a cluster with two related genes on chromosome 12. Alternative splicing results in multiple transcript variants.(provided by RefSeq, Jul 2012)
|
Genomic Views
for GLIPR1L2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for GLIPR1L2
Other transcription factors
Search SABiosciences Chromatin IP Primers for GLIPR1L2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GLIPR1L2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q21.2 Ensembl cytogenetic band: 12q21.2 HGNC cytogenetic band: 12q21.1GLIPR1L2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P075784: view genomic region
(about GC identifiers)
Start:
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75,784,850 bp from pter |
End:
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75,826,468 bp from pter |
Size:
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41,619 bases |
Orientation:
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plus strand |
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Proteins
for GLIPR1L2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: GRPL2_HUMAN, Q4G1C9 (See
protein sequence)Recommended Name: GLIPR1-like protein 2 Size: 344 amino acids; 40179 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Sequence caution: Sequence=AAH16749.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-Asequence; Sequence=BAC04085.1; Type=Erroneous termination; Positions=230; Note=Translated as Gln; Sequence=CAE45957.1;Type=Erroneous initiation;
Secondary accessions: Q6MZS1 Q8N6N0 Q8NA43Alternative splicing: 6 isoforms: Q4G1C9-1 Q4G1C9-2 Q4G1C9-3 Q4G1C9-4 Q4G1C9-5 Q4G1C9-6 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for GLIPR1L2: NX_Q4G1C9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q4G1C9
GLIPR1L2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001257325.1 NP_689649.1
ENSEMBL proteins: ENSP00000448248 ENSP00000367963 ENSP00000317385 ENSP00000447980 ENSP00000398328 ENSP00000367960 ENSP00000405273
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
GLIPR1L2 for ontologies About GeneDecksing
GLIPR1L2 Antibody Products:
Assay Products for GLIPR1L2: |
Protein
Domains /
Families
for GLIPR1L2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GLIPR1L2 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q4G1C9ProtoNet protein and cluster: Q4G1C9 1 Blocks protein family: IPB001283 Allergen V5/Tpx-1 related
UniProtKB/Swiss-Prot: GRPL2_HUMAN, Q4G1C9Similarity: Belongs to the CRISP family |
Function
for GLIPR1L2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: GRPL2_HUMAN, Q4G1C9Induction: Up-regulated by doxycycline
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GLIPR1L2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GLIPR1L2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GLIPR1L2 |
1 GenomeRNAi human phenotype for GLIPR1L2:
|
Pathways & Interactions
for GLIPR1L2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GLIPR1L2
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for GLIPR1L2 (ENSP000003173854) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for GLIPR1L2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for GLIPR1L2
Search CenterWatch for drugs/clinical trials and news about GLIPR1L2 / GRPL2
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Transcripts
for GLIPR1L2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for GLIPR1L2 gene (2 alternative transcripts): NM_001270396.1 NM_152436.2 Unigene Cluster for GLIPR1L2: GLI pathogenesis-related 1 like 2 Hs.406728 [show with all ESTs]Unigene Representative Sequence: NR_0729957 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000550916(uc001sxr.1) ENST00000378692(uc001sxq.1) ENST00000320460(uc001sxp.1)
ENST00000547164 ENST00000435775 ENST00000378689 ENST00000441218
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GLIPR1L2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GLIPR1L2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: GLIPR1L2 (NM_152436) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GLIPR1L2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GLIPR1L2 |
Additional cDNA sequence: AK093175.1 BC016749.1 BC029557.1 BC032022.1 BX640916.1 NR_072995.1 3 DOTS entries: DT.40208089 DT.91736350 DT.101978441 24/34 AceView cDNA sequences (see all 34): BC032022 BC029557 AK093175 BG203265 AX747973 BG209722 BX640916 BP378831 BG717916 NM_152436 BC016749 BQ429166 BG718710 BG204772 BG214790 BG214441 BG219504 BI548529 AA813702 H97952 AV726710 BG201172 BG722054 AA649108
GeneLoc Exon Structure
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Expression
for GLIPR1L2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| GLIPR1L2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAAATATTCC
About this image
See GLIPR1L2 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.406728
UniProtKB/Swiss-Prot: GRPL2_HUMAN, Q4G1C9Tissue specificity: Highly expressed in testis. Detected in prostate, kidney, bladder, lung and bone marrow
SABiosciences Custom PCR Arrays for GLIPR1L2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GLIPR1L2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GLIPR1L2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GLIPR1L2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GLIPR1L2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GLIPR1L2 |
Orthologs
for GLIPR1L2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for GLIPR1L2 gene from 4/14 species (see all 14) About this table
ENSEMBL Gene Tree for GLIPR1L2 (if available)
TreeFam Gene Tree for GLIPR1L2 (if available) |
Paralogs
for GLIPR1L2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for GLIPR1L2 gene
- CLEC18B2 CRISPLD22 CLEC18C2 PI162 GLIPR12 CRISP22 PI152 CRISP12
- CRISPLD12 CRISP32 GLIPR1L12 CLEC18A2 R3HDML2
2 SIMAP similar genes for GLIPR1L2 using alignment to 1 protein entry: GRPL2_HUMAN:GLIPR1 GLIPR1L1
GLIPR1L2 for paralogs About GeneDecksing
|
Genomic Variants
for GLIPR1L2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for GLIPR1L2 (75784850 - 75826468 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for GLIPR1L2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GLIPR1L2 |
|
Disorders
/ Diseases
for GLIPR1L2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
GLIPR1L2 for disorders About GeneDecksing
OMIM gene information: 610394
OMIM disorders: --
1  disease for GLIPR1L2: About MalaCardsprostatitis
Export disorders for GLIPR1L2 gene to outside databases
|
Publications
for GLIPR1L2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for GLIPR1L2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with GLIPR1L2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and characterization of RTVP1/GLIPR1-like genes, a novel p53 target gene cluster. (PubMed id 16714093)1, 2 Ren C.... Thompson T.C. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Protein phosphatase 1a interacting proteins in the hum an brain. (PubMed id 22321011)1 Esteves S.L....da Cruz e Silva E.F. (2012)
- Examining Hedgehog pathway genes GLI3, SHH, and PTCH1 and the p53 target GLIPR1/GLIPR1L1/GLIPR1L2 gene cluster using fluorescence in s itu hybridization uncovers GLIPR1/GLIPR1L1/GLIPR1L2 deletion in 9% of patients w ith multiple myeloma. (PubMed id 20978342)1 Tam M....Lennon P.A. (2010)
- The CAP superfamily: cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins--roles in reproduction, cancer, and immune defense. (PubMed id 18824526)1 Gibbs G.M....O'Bryan M.K. (2008)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
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External Searches for GLIPR1L2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing GLIPR1L2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing GLIPR1L2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GLIPR1L2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for GLIPR1L2 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for GLIPR1L2 gene:
Search GeneIP for patents involving GLIPR1L2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for GLIPR1L2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for GLIPR1L2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GLIPR1L2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GLIPR1L2 | | | OriGene Protein Over-expression Lysate for GLIPR1L2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for GLIPR1L2 | | OriGene 3'-UTR Clone for GLIPR1L2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GLIPR1L2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GLIPR1L2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for GLIPR1L2 | | OriGene Custom Protein Services for GLIPR1L2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GLIPR1L2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GLIPR1L2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GLIPR1L2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GLIPR1L2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GLIPR1L2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GLIPR1L2 |
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 | | | GLIPR1L2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GLIPR1L2 |
|  |  |  | | | | Search ThermoFisher Antibodies for GLIPR1L2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GLIPR1L2 |
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