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Aliases for GLIPR1L1 Gene

Aliases for GLIPR1L1 Gene

  • GLI Pathogenesis Related 1 Like 1 2 3 5
  • GLI Pathogenesis-Related 1 Like 1 2
  • GLIPR1-Like Protein 1 3
  • ALKN2972 3
  • PRO7434 3

External Ids for GLIPR1L1 Gene

Previous GeneCards Identifiers for GLIPR1L1 Gene

  • GC12P074016
  • GC12P075728
  • GC12P072777

Summaries for GLIPR1L1 Gene

GeneCards Summary for GLIPR1L1 Gene

GLIPR1L1 (GLI Pathogenesis Related 1 Like 1) is a Protein Coding gene. An important paralog of this gene is GLIPR1.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLIPR1L1 Gene

Genomics for GLIPR1L1 Gene

Regulatory Elements for GLIPR1L1 Gene

Enhancers for GLIPR1L1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G075366 0.6 ENCODE 68.8 +32.2 32249 1.3 PKNOX1 BHLHE40 JUNB EP300 FOSL1 JUND RAD51 PRDM10 FOS MAFK GLIPR1L1 ENSG00000257497 CAPS2
GH12G075508 1.7 FANTOM5 ENCODE dbSUPER 11.9 +176.1 176084 4.9 PKNOX1 CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 KRR1 ENSG00000257497 GLIPR1L2 GLIPR1L1 GLIPR1 CAPS2 PHLDA1 KCNC2
GH12G075477 1.6 FANTOM5 ENCODE dbSUPER 11.8 +147.1 147123 7.5 HDGF FOXA2 ATF1 WRNIP1 SIN3A YY1 ZNF207 FOS JUNB MIER2 GLIPR1L2 KRR1 GLIPR1L1 CAPS2 ENSG00000257497 GLIPR1
GH12G075322 0.4 Ensembl 46.5 -12.0 -12024 0.4 EP300 GLIPR1L1 ENSG00000273987 LOC100419702
GH12G075507 1.3 FANTOM5 dbSUPER 11.9 +172.7 172743 0.5 TBP ELF3 FOXA2 MLX ARID4B DMAP1 THRB ZNF48 RAD21 RARA KRR1 GLIPR1L1 GLIPR1 CAPS2 GLIPR1L2 PHLDA1 KCNC2 ENSG00000257497
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GLIPR1L1 on UCSC Golden Path with GeneCards custom track

Promoters for GLIPR1L1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000054009 61 601 PKNOX1 SIN3A ZNF2 RAD21 EGR1 ZNF366 SCRT2 ZNF143 CREM EGR2

Genomic Location for GLIPR1L1 Gene

Chromosome:
12
Start:
75,334,639 bp from pter
End:
75,370,560 bp from pter
Size:
35,922 bases
Orientation:
Plus strand

Genomic View for GLIPR1L1 Gene

Genes around GLIPR1L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GLIPR1L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GLIPR1L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLIPR1L1 Gene

Proteins for GLIPR1L1 Gene

  • Protein details for GLIPR1L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UWM5-GPRL1_HUMAN
    Recommended name:
    GLIPR1-like protein 1
    Protein Accession:
    Q6UWM5
    Secondary Accessions:
    • Q96L06

    Protein attributes for GLIPR1L1 Gene

    Size:
    242 amino acids
    Molecular mass:
    27151 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GLIPR1L1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GLIPR1L1 Gene

Post-translational modifications for GLIPR1L1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GLIPR1L1 Gene

No data available for DME Specific Peptides for GLIPR1L1 Gene

Domains & Families for GLIPR1L1 Gene

Suggested Antigen Peptide Sequences for GLIPR1L1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UWM5

UniProtKB/Swiss-Prot:

GPRL1_HUMAN :
  • Belongs to the CRISP family.
Family:
  • Belongs to the CRISP family.
genes like me logo Genes that share domains with GLIPR1L1: view

No data available for Gene Families for GLIPR1L1 Gene

Function for GLIPR1L1 Gene

genes like me logo Genes that share phenotypes with GLIPR1L1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GLIPR1L1

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GLIPR1L1 Gene

Localization for GLIPR1L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLIPR1L1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GLIPR1L1 gene
Compartment Confidence
extracellular 5
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for GLIPR1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with GLIPR1L1: view

Pathways & Interactions for GLIPR1L1 Gene

SuperPathways for GLIPR1L1 Gene

No Data Available

Interacting Proteins for GLIPR1L1 Gene

Gene Ontology (GO) - Biological Process for GLIPR1L1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GLIPR1L1 Gene

Drugs & Compounds for GLIPR1L1 Gene

No Compound Related Data Available

Transcripts for GLIPR1L1 Gene

Unigene Clusters for GLIPR1L1 Gene

GLI pathogenesis-related 1 like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GLIPR1L1 Gene

No ASD Table

Relevant External Links for GLIPR1L1 Gene

GeneLoc Exon Structure for
GLIPR1L1
ECgene alternative splicing isoforms for
GLIPR1L1

Expression for GLIPR1L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GLIPR1L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GLIPR1L1 Gene

This gene is overexpressed in Testis (x33.0).

Protein differential expression in normal tissues from HIPED for GLIPR1L1 Gene

This gene is overexpressed in Ovary (39.5) and Testis (29.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GLIPR1L1 Gene



Protein tissue co-expression partners for GLIPR1L1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GLIPR1L1 Gene:

GLIPR1L1

SOURCE GeneReport for Unigene cluster for GLIPR1L1 Gene:

Hs.567788

mRNA Expression by UniProt/SwissProt for GLIPR1L1 Gene:

Q6UWM5-GPRL1_HUMAN
Tissue specificity: Highly expressed in testis.
genes like me logo Genes that share expression patterns with GLIPR1L1: view

Primer Products

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GLIPR1L1 Gene

Orthologs for GLIPR1L1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GLIPR1L1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GLIPR1L1 34 35
  • 99.28 (n)
cow
(Bos Taurus)
Mammalia GLIPR1L1 34 35
  • 70.98 (n)
rat
(Rattus norvegicus)
Mammalia Glipr1l1 34
  • 64.9 (n)
mouse
(Mus musculus)
Mammalia Glipr1l3 34 16
  • 63.89 (n)
Glipr1l1 35
  • 46 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GLIPR1L1 35
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GLIPR1L1 35
  • 49 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GLIPR1L1 35
  • 36 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 33 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 38 (a)
ManyToMany
-- 35
  • 35 (a)
ManyToMany
-- 35
  • 33 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia glipr1l1 34
  • 49.3 (n)
zebrafish
(Danio rerio)
Actinopterygii CU694453.1 35
  • 32 (a)
ManyToMany
glipr1b 35
  • 32 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea scl-1 35
  • 28 (a)
ManyToMany
scl-11 35
  • 26 (a)
ManyToMany
scl-12 35
  • 26 (a)
ManyToMany
scl-14 35
  • 26 (a)
ManyToMany
scl-15 35
  • 26 (a)
ManyToMany
scl-2 35
  • 26 (a)
ManyToMany
scl-13 35
  • 25 (a)
ManyToMany
scl-5 35
  • 25 (a)
ManyToMany
scl-20 35
  • 24 (a)
ManyToMany
scl-3 35
  • 24 (a)
ManyToMany
scl-7 35
  • 24 (a)
ManyToMany
scl-9 35
  • 24 (a)
ManyToMany
scl-10 35
  • 23 (a)
ManyToMany
scl-21 35
  • 23 (a)
ManyToMany
scl-6 35
  • 23 (a)
ManyToMany
scl-8 35
  • 23 (a)
ManyToMany
scl-18 35
  • 21 (a)
ManyToMany
scl-19 35
  • 21 (a)
ManyToMany
scl-17 35
  • 20 (a)
ManyToMany
Species where no ortholog for GLIPR1L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GLIPR1L1 Gene

ENSEMBL:
Gene Tree for GLIPR1L1 (if available)
TreeFam:
Gene Tree for GLIPR1L1 (if available)

Paralogs for GLIPR1L1 Gene

(6) SIMAP similar genes for GLIPR1L1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GLIPR1L1: view

Variants for GLIPR1L1 Gene

Sequence variations from dbSNP and Humsavar for GLIPR1L1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000016463 -- 75,354,167(+) AAAAG(-/C)GGGGG intron-variant
rs1000030049 -- 75,347,022(+) ACTAG(A/T)TTTCC intron-variant
rs1000056925 -- 75,332,455(+) TTTGA(C/G)AAACA intron-variant, utr-variant-5-prime
rs1000080217 -- 75,346,637(+) GCCCG(C/T)CTCAG intron-variant
rs1000219512 -- 75,350,123(+) ACAGT(C/T)TGTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GLIPR1L1 Gene

Variant ID Type Subtype PubMed ID
dgv98n21 CNV gain 19592680
esv3630011 CNV gain 21293372
nsv1054059 CNV loss 25217958
nsv520316 CNV loss 19592680

Variation tolerance for GLIPR1L1 Gene

Residual Variation Intolerance Score: 59.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.03; 37.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GLIPR1L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GLIPR1L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLIPR1L1 Gene

Disorders for GLIPR1L1 Gene

Relevant External Links for GLIPR1L1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GLIPR1L1

No disorders were found for GLIPR1L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GLIPR1L1 Gene

Publications for GLIPR1L1 Gene

  1. Identification and characterization of RTVP1/GLIPR1-like genes, a novel p53 target gene cluster. (PMID: 16714093) Ren C. … Thompson T.C. (Genomics 2006) 3 4 64
  2. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64

Products for GLIPR1L1 Gene

Sources for GLIPR1L1 Gene

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