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Aliases for GLIPR1 Gene

Aliases for GLIPR1 Gene

  • GLI Pathogenesis Related 1 2 3 5
  • GLI Pathogenesis-Related 1 (Glioma) 2 3
  • Protein RTVP-1 3 4
  • GliPR 1 3 4
  • GLIPR 3 4
  • RTVP1 3 4
  • Related To Testis-Specific, Vespid, And Pathogenesis Proteins 1 3
  • Testes-Specific Vespid And Pathogenesis Protein 1 3
  • Glioma Pathogenesis-Related Protein 1 3
  • CRISP7 3

External Ids for GLIPR1 Gene

Previous GeneCards Identifiers for GLIPR1 Gene

  • GC12P075800
  • GC12P075591
  • GC12P074160
  • GC12P072924

Summaries for GLIPR1 Gene

Entrez Gene Summary for GLIPR1 Gene

  • This gene encodes a protein with similarity to both the pathogenesis-related protein (PR) superfamily and the cysteine-rich secretory protein (CRISP) family. Increased expression of this gene is associated with myelomocytic differentiation in macrophage and decreased expression of this gene through gene methylation is associated with prostate cancer. The protein has proapoptotic activities in prostate and bladder cancer cells. This gene is a member of a cluster on chromosome 12 containing two other similar genes. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for GLIPR1 Gene

GLIPR1 (GLI Pathogenesis Related 1) is a Protein Coding gene. Diseases associated with GLIPR1 include Glioma and Nervous System Cancer. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Metabolism. An important paralog of this gene is GLIPR1L2.

Gene Wiki entry for GLIPR1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLIPR1 Gene

Genomics for GLIPR1 Gene

Regulatory Elements for GLIPR1 Gene

Enhancers for GLIPR1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F075508 1.5 FANTOM5 ENCODE 11.2 +30.0 30043 4.9 PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 KRR1 ENSG00000257497 GLIPR1L2 GLIPR1L1 GLIPR1 CAPS2 PHLDA1 KCNC2
GH12F075683 1.1 Ensembl ENCODE 11.5 +203.9 203930 2.7 HDAC1 CBX3 ATF1 PTRF ELK1 FOS ZBTB11 HDAC8 CREB3 MEF2D GLIPR1 RPL10P13 GC12P075601
GH12F075908 1.1 Ensembl ENCODE 11.5 +429.0 429004 2.1 PTRF ZNF48 RAD21 YY1 SMAD5 CREB3 MEF2D PBX2 HMBOX1 IRF1 GLIPR1 ENSG00000258091 LOC105369846
GH12F075388 1.1 ENCODE 11.3 -90.2 -90200 3.9 HDGF ATF1 PKNOX1 WRNIP1 SIN3A GLI4 ZNF2 YY1 CBX5 ZNF143 GLIPR1L2 KRR1 GLIPR1 ATXN7L3B CAPS2 GLIPR1L1
GH12F075437 1 Ensembl ENCODE 11.9 -42.4 -42430 1.1 HDAC1 CTCF KLF1 ESRRA LEF1 TBL1XR1 ZNF175 RAD21 FOSL1 NCOR1 GLIPR1L2 GLIPR1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GLIPR1 on UCSC Golden Path with GeneCards custom track

Promoters for GLIPR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001464878 1120 3601 HDGF TBP ATF1 SIN3A BMI1 ZNF366 FOS CREM CBFB CEBPB

Genomic Location for GLIPR1 Gene

Chromosome:
12
Start:
75,480,680 bp from pter
End:
75,503,853 bp from pter
Size:
23,174 bases
Orientation:
Plus strand

Genomic View for GLIPR1 Gene

Genes around GLIPR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GLIPR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GLIPR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLIPR1 Gene

Proteins for GLIPR1 Gene

  • Protein details for GLIPR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48060-GLIP1_HUMAN
    Recommended name:
    Glioma pathogenesis-related protein 1
    Protein Accession:
    P48060
    Secondary Accessions:
    • A7YET6
    • F8VUC2
    • Q15409
    • Q969K2

    Protein attributes for GLIPR1 Gene

    Size:
    266 amino acids
    Molecular mass:
    30366 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA82731.3; Type=Frameshift; Positions=3; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GLIPR1 Gene

    Alternative splice isoforms for GLIPR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GLIPR1 Gene

Post-translational modifications for GLIPR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GLIPR1 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for GLIPR1

No data available for DME Specific Peptides for GLIPR1 Gene

Domains & Families for GLIPR1 Gene

Protein Domains for GLIPR1 Gene

Suggested Antigen Peptide Sequences for GLIPR1 Gene

Graphical View of Domain Structure for InterPro Entry

P48060

UniProtKB/Swiss-Prot:

GLIP1_HUMAN :
  • Contains 1 SCP domain.
  • Belongs to the CRISP family.
Domain:
  • Contains 1 SCP domain.
Family:
  • Belongs to the CRISP family.
genes like me logo Genes that share domains with GLIPR1: view

No data available for Gene Families for GLIPR1 Gene

Function for GLIPR1 Gene

Phenotypes for GLIPR1 Gene

MGI mutant phenotypes for GLIPR1:
inferred from 1 alleles
GenomeRNAi human phenotypes for GLIPR1:
genes like me logo Genes that share phenotypes with GLIPR1: view

Animal Models for GLIPR1 Gene

MGI Knock Outs for GLIPR1:

Animal Model Products

  • Taconic Biosciences Mouse Models for GLIPR1

miRNA for GLIPR1 Gene

miRTarBase miRNAs that target GLIPR1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GLIPR1 Gene

Localization for GLIPR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLIPR1 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GLIPR1 gene
Compartment Confidence
plasma membrane 5
extracellular 4
lysosome 4
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GLIPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA,IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GLIPR1: view

Pathways & Interactions for GLIPR1 Gene

genes like me logo Genes that share pathways with GLIPR1: view

Interacting Proteins for GLIPR1 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 17)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000266659%0d%0a9606.ENSP00000417401%0d%0a9606.ENSP00000262735%0d%0a9606.ENSP00000262367%0d%0a9606.ENSP00000405574%0d%0a9606.ENSP00000325690%0d%0a
Selected Interacting proteins: P48060-GLIP1_HUMAN ENSP00000266659 for GLIPR1 Gene via IID STRING

Gene Ontology (GO) - Biological Process for GLIPR1 Gene

None

No data available for SIGNOR curated interactions for GLIPR1 Gene

Drugs & Compounds for GLIPR1 Gene

(1) Drugs for GLIPR1 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
SOT-107 Investigational Pharma Target 0
genes like me logo Genes that share compounds with GLIPR1: view

Transcripts for GLIPR1 Gene

Unigene Clusters for GLIPR1 Gene

GLI pathogenesis-related 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GLIPR1 Gene

No ASD Table

Relevant External Links for GLIPR1 Gene

GeneLoc Exon Structure for
GLIPR1
ECgene alternative splicing isoforms for
GLIPR1

Expression for GLIPR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GLIPR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GLIPR1 Gene

This gene is overexpressed in Whole Blood (x13.5) and Artery - Aorta (x5.6).

Protein differential expression in normal tissues from HIPED for GLIPR1 Gene

This gene is overexpressed in Monocytes (45.0) and NK cells (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GLIPR1 Gene



Protein tissue co-expression partners for GLIPR1 Gene

NURSA nuclear receptor signaling pathways regulating expression of GLIPR1 Gene:

GLIPR1

SOURCE GeneReport for Unigene cluster for GLIPR1 Gene:

Hs.205558

mRNA Expression by UniProt/SwissProt for GLIPR1 Gene:

P48060-GLIP1_HUMAN
Tissue specificity: According to PubMed:8973356, it is ubiquitously expressed with high levels in lung and kidney and low levels in heart and liver. Highly expressed in cell lines derived from nervous system tumors arising from glia, low or absent in non-glial-derived nervous system tumor cell lines. Also found in fetal kidney. According to PubMed:7607567 it is expressed only in brain tumor glioblastoma multiforme/astrocytoma and not in other nervous system tumors or normal fetal or adult tissues.
genes like me logo Genes that share expression patterns with GLIPR1: view

Orthologs for GLIPR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GLIPR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GLIPR1 34 35
  • 99.5 (n)
cow
(Bos Taurus)
Mammalia GLIPR1 34 35
  • 83.33 (n)
mouse
(Mus musculus)
Mammalia Glipr1 34 16 35
  • 78.82 (n)
dog
(Canis familiaris)
Mammalia GLIPR1 34 35
  • 76.93 (n)
rat
(Rattus norvegicus)
Mammalia Glipr1 34
  • 75.83 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 63 (a)
OneToMany
-- 35
  • 49 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia GLIPR1 35
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves GLIPR1 34
  • 66.51 (n)
-- 35
  • 49 (a)
OneToMany
GLIPR1L 35
  • 48 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 46 (a)
OneToMany
-- 35
  • 45 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii LOC101886846 34
  • 54.51 (n)
worm
(Caenorhabditis elegans)
Secernentea scl-5 35
  • 30 (a)
ManyToMany
scl-15 35
  • 29 (a)
ManyToMany
scl-2 35
  • 29 (a)
ManyToMany
scl-7 35
  • 29 (a)
ManyToMany
scl-1 35
  • 28 (a)
ManyToMany
scl-14 35
  • 28 (a)
ManyToMany
scl-20 35
  • 28 (a)
ManyToMany
scl-3 35
  • 28 (a)
ManyToMany
scl-12 35
  • 27 (a)
ManyToMany
scl-11 35
  • 26 (a)
ManyToMany
scl-13 35
  • 26 (a)
ManyToMany
scl-6 35
  • 26 (a)
ManyToMany
scl-8 35
  • 26 (a)
ManyToMany
scl-10 35
  • 25 (a)
ManyToMany
scl-21 35
  • 25 (a)
ManyToMany
scl-9 35
  • 23 (a)
ManyToMany
scl-18 35
  • 22 (a)
ManyToMany
scl-19 35
  • 22 (a)
ManyToMany
scl-17 35
  • 21 (a)
ManyToMany
Species where no ortholog for GLIPR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GLIPR1 Gene

ENSEMBL:
Gene Tree for GLIPR1 (if available)
TreeFam:
Gene Tree for GLIPR1 (if available)

Paralogs for GLIPR1 Gene

(7) SIMAP similar genes for GLIPR1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with GLIPR1: view

Variants for GLIPR1 Gene

Sequence variations from dbSNP and Humsavar for GLIPR1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1051446 -- 75,500,334(+) TTCCA(C/T)CTTGC intron-variant, utr-variant-3-prime
rs1056900 -- 75,499,706(-) TTTTT(C/T)TTTTT utr-variant-3-prime
rs1056903 -- 75,499,624(+) TTTCT(A/C)GTATA utr-variant-3-prime
rs1056904 -- 75,499,619(-) GAGAA(A/C)GTGGT utr-variant-3-prime
rs1056905 -- 75,499,608(+) AAGAC(A/T)TATAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for GLIPR1 Gene

Variant ID Type Subtype PubMed ID
nsv826439 CNV gain 20364138
esv3373789 CNV insertion 20981092

Variation tolerance for GLIPR1 Gene

Residual Variation Intolerance Score: 71.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.70; 14.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GLIPR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GLIPR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLIPR1 Gene

Disorders for GLIPR1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for GLIPR1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
glioma
nervous system cancer
  • malignant neoplasm of nervous system
prostate cancer
  • prostate cancer, hereditary, 5
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for GLIPR1

Genetic Association Database (GAD)
GLIPR1
Human Genome Epidemiology (HuGE) Navigator
GLIPR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GLIPR1
genes like me logo Genes that share disorders with GLIPR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GLIPR1 Gene

Publications for GLIPR1 Gene

  1. RTVP-1, a novel human gene with sequence similarity to genes of diverse species, is expressed in tumor cell lines of glial but not neuronal origin. (PMID: 8973356) Rich T. … Israel M.A. (Gene 1996) 2 3 4 22 64
  2. The human glioma pathogenesis-related protein is structurally related to plant pathogenesis-related proteins and its gene is expressed specifically in brain tumors. (PMID: 7607567) Murphy E.V. … Biggs J. (Gene 1995) 2 3 4 22 64
  3. Structure comparison of human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein P14a indicates a functional link between the human immune system and a plant defense system. (PMID: 9482873) Szyperski T. … Wuethrich K. (Proc. Natl. Acad. Sci. U.S.A. 1998) 3 4 22 64
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  5. [Methylation and expression of glioma pathogenesis-related protein 1 gene in acute myeloid leukemia]. (PMID: 19483285) Liang T. … Xiao Z. (Zhong Nan Da Xue Xue Bao Yi Xue Ban 2009) 3 22 64

Products for GLIPR1 Gene

Sources for GLIPR1 Gene

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