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Aliases for GLIPR1 Gene

Aliases for GLIPR1 Gene

  • GLI Pathogenesis-Related 1 2 3
  • GLIPR 3 4 6
  • RTVP1 3 4 6
  • GLI Pathogenesis-Related 1 (Glioma) 2 3
  • Protein RTVP-1 3 4
  • GliPR 1 3 4
  • Related To Testis-Specific, Vespid, And Pathogenesis Proteins 1 3
  • Testes-Specific Vespid And Pathogenesis Protein 1 3
  • Glioma Pathogenesis-Related Protein 1 3
  • CRISP7 3

External Ids for GLIPR1 Gene

Summaries for GLIPR1 Gene

Entrez Gene Summary for GLIPR1 Gene

  • This gene encodes a protein with similarity to both the pathogenesis-related protein (PR) superfamily and the cysteine-rich secretory protein (CRISP) family. Increased expression of this gene is associated with myelomocytic differentiation in macrophage and decreased expression of this gene through gene methylation is associated with prostate cancer. The protein has proapoptotic activities in prostate and bladder cancer cells. This gene is a member of a cluster on chromosome 12 containing two other similar genes. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for GLIPR1 Gene

GLIPR1 (GLI Pathogenesis-Related 1) is a Protein Coding gene. Diseases associated with GLIPR1 include prostate cancer and glioblastoma multiforme. Among its related pathways are Metabolism and Metabolism. An important paralog of this gene is CLEC18B.

Gene Wiki entry for GLIPR1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLIPR1 Gene

Genomics for GLIPR1 Gene

Genomic Location for GLIPR1 Gene

Start:
75,480,680 bp from pter
End:
75,503,853 bp from pter
Size:
23,174 bases
Orientation:
Plus strand

Genomic View for GLIPR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GLIPR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLIPR1 Gene

Regulatory Elements for GLIPR1 Gene

Proteins for GLIPR1 Gene

  • Protein details for GLIPR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48060-GLIP1_HUMAN
    Recommended name:
    Glioma pathogenesis-related protein 1
    Protein Accession:
    P48060
    Secondary Accessions:
    • A7YET6
    • F8VUC2
    • Q15409
    • Q969K2

    Protein attributes for GLIPR1 Gene

    Size:
    266 amino acids
    Molecular mass:
    30366 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA82731.3; Type=Frameshift; Positions=3; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GLIPR1 Gene

    Alternative splice isoforms for GLIPR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GLIPR1 Gene

Proteomics data for GLIPR1 Gene at MOPED

Post-translational modifications for GLIPR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GLIPR1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for GLIPR1 Gene

Domains for GLIPR1 Gene

Protein Domains for GLIPR1 Gene

UniProtKB/Swiss-Prot:

GLIP1_HUMAN
Domain:
  • Contains 1 SCP domain.:
    • P48060
Family:
  • Belongs to the CRISP family.:
    • P48060
genes like me logo Genes that share domains with GLIPR1: view

No data available for Gene Families for GLIPR1 Gene

Function for GLIPR1 Gene

Phenotypes for GLIPR1 Gene

MGI mutant phenotypes for GLIPR1:
inferred from 1 alleles
GenomeRNAi human phenotypes for GLIPR1:
genes like me logo Genes that share phenotypes with GLIPR1: view

Animal Models for GLIPR1 Gene

MGI Knock Outs for GLIPR1:

miRNA for GLIPR1 Gene

miRTarBase miRNAs that target GLIPR1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targeting and HOMER Transcription for GLIPR1 Gene

Localization for GLIPR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLIPR1 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GLIPR1 Gene COMPARTMENTS Subcellular localization image for GLIPR1 gene
Compartment Confidence
plasma membrane 4
extracellular 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GLIPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GLIPR1: view

Pathways for GLIPR1 Gene

genes like me logo Genes that share pathways with GLIPR1: view

Interacting Proteins for GLIPR1 Gene

Gene Ontology (GO) - Biological Process for GLIPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044255 cellular lipid metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with GLIPR1: view

Transcripts for GLIPR1 Gene

Unigene Clusters for GLIPR1 Gene

GLI pathogenesis-related 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GLIPR1 Gene

No ASD Table

Relevant External Links for GLIPR1 Gene

GeneLoc Exon Structure for
GLIPR1
ECgene alternative splicing isoforms for
GLIPR1

Expression for GLIPR1 Gene

mRNA expression in normal human tissues for GLIPR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GLIPR1 Gene

This gene is overexpressed in Whole Blood (13.5) and Artery - Aorta (5.6).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for GLIPR1 Gene

SOURCE GeneReport for Unigene cluster for GLIPR1 Gene Hs.205558

mRNA Expression by UniProt/SwissProt for GLIPR1 Gene

P48060-GLIP1_HUMAN
Tissue specificity: According to PubMed:8973356, it is ubiquitously expressed with high levels in lung and kidney and low levels in heart and liver. Highly expressed in cell lines derived from nervous system tumors arising from glia, low or absent in non-glial-derived nervous system tumor cell lines. Also found in fetal kidney. According to PubMed:7607567 it is expressed only in brain tumor glioblastoma multiforme/astrocytoma and not in other nervous system tumors or normal fetal or adult tissues
genes like me logo Genes that share expressions with GLIPR1: view

Orthologs for GLIPR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GLIPR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GLIPR1 36
  • 99.5 (n)
  • 100 (a)
GLIPR1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GLIPR1 36
  • 83.33 (n)
  • 78.03 (a)
GLIPR1 37
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GLIPR1 36
  • 76.93 (n)
  • 71.1 (a)
GLIPR1 37
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Glipr1 36
  • 78.82 (n)
  • 71.76 (a)
Glipr1 16
Glipr1 37
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GLIPR1 37
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 49 (a)
OneToMany
-- 37
  • 63 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Glipr1 36
  • 75.83 (n)
  • 67.73 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 49 (a)
OneToMany
GLIPR1 36
  • 66.51 (n)
  • 57.67 (a)
GLIPR1L 37
  • 48 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 45 (a)
OneToMany
-- 37
  • 46 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii LOC101886846 36
  • 54.51 (n)
  • 48.5 (a)
worm
(Caenorhabditis elegans)
Secernentea scl-1 37
  • 28 (a)
ManyToMany
scl-10 37
  • 25 (a)
ManyToMany
scl-11 37
  • 26 (a)
ManyToMany
scl-12 37
  • 27 (a)
ManyToMany
scl-13 37
  • 26 (a)
ManyToMany
scl-14 37
  • 28 (a)
ManyToMany
scl-15 37
  • 29 (a)
ManyToMany
scl-17 37
  • 21 (a)
ManyToMany
scl-18 37
  • 22 (a)
ManyToMany
scl-19 37
  • 22 (a)
ManyToMany
scl-2 37
  • 29 (a)
ManyToMany
scl-20 37
  • 28 (a)
ManyToMany
scl-21 37
  • 25 (a)
ManyToMany
scl-3 37
  • 28 (a)
ManyToMany
scl-5 37
  • 30 (a)
ManyToMany
scl-6 37
  • 26 (a)
ManyToMany
scl-7 37
  • 29 (a)
ManyToMany
scl-8 37
  • 26 (a)
ManyToMany
scl-9 37
  • 23 (a)
ManyToMany
Species with no ortholog for GLIPR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GLIPR1 Gene

ENSEMBL:
Gene Tree for GLIPR1 (if available)
TreeFam:
Gene Tree for GLIPR1 (if available)

Paralogs for GLIPR1 Gene

Selected SIMAP similar genes for GLIPR1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with GLIPR1: view

Variants for GLIPR1 Gene

Sequence variations from dbSNP and Humsavar for GLIPR1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs15513 -- 75,494,471(-) CAATG(C/T)AGTGA intron-variant
rs1501634 -- 75,496,553(+) CACAA(A/G)CCCTT intron-variant
rs1875471 -- 75,482,679(+) TTATT(A/T)GTCCC intron-variant
rs1909979 -- 75,481,796(+) CATTT(C/T)AGATG intron-variant
rs2242435 -- 75,481,133(-) TATTA(C/T)GAAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GLIPR1 Gene

Variant ID Type Subtype PubMed ID
nsv899313 CNV Gain 21882294
esv273819 CNV Insertion 20981092
nsv826439 CNV Gain 20364138

Relevant External Links for GLIPR1 Gene

HapMap Linkage Disequilibrium report
GLIPR1

Disorders for GLIPR1 Gene

(5) Novoseek inferred disease relationships for GLIPR1 Gene

Disease -log(P) Hits PubMed IDs
nervous system tumor 82.2 2
glioma 61.6 7
glioblastoma multiforme 54.4 2
brain tumors 37.6 1
tumors 9.27 9

Relevant External Links for GLIPR1

Genetic Association Database (GAD)
GLIPR1
Human Genome Epidemiology (HuGE) Navigator
GLIPR1
genes like me logo Genes that share disorders with GLIPR1: view

No data available for UniProtKB/Swiss-Prot for GLIPR1 Gene

Publications for GLIPR1 Gene

  1. The human glioma pathogenesis-related protein is structurally related to plant pathogenesis-related proteins and its gene is expressed specifically in brain tumors. (PMID: 7607567) Murphy E.V. … Biggs J. (Gene 1995) 2 3 4 23
  2. RTVP-1, a novel human gene with sequence similarity to genes of diverse species, is expressed in tumor cell lines of glial but not neuronal origin. (PMID: 8973356) Rich T. … Israel M.A. (Gene 1996) 2 3 4 23
  3. Structure comparison of human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein P14a indicates a functional link between the human immune system and a plant defense system. (PMID: 9482873) Szyperski T. … Wuethrich K. (Proc. Natl. Acad. Sci. U.S.A. 1998) 3 4 23
  4. Identification and characterization of RTVP1/GLIPR1-like genes, a novel p53 target gene cluster. (PMID: 16714093) Ren C. … Thompson T.C. (Genomics 2006) 3 23
  5. Glioma pathogenesis-related protein 1 exerts tumor suppressor activities through proapoptotic reactive oxygen species-c-Jun-NH2 kinase signaling. (PMID: 18199537) Li L. … Thompson T.C. (Cancer Res. 2008) 3 23

Products for GLIPR1 Gene

Sources for GLIPR1 Gene

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