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GLIPR1 Gene

protein-coding   GIFtS: 58
GCID: GC12P075800

GLI Pathogenesis-Related 1

(Previous name: GLI pathogenesis-related 1 (glioma))
  See GLIPR1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
GLI Pathogenesis-Related 11 2     Protein RTVP-12 3
GLIPR2 3 5     CRISP72
RTVP12 3 5     Glioma Pathogenesis-Related Protein 12
GLI Pathogenesis-Related 1 (Glioma)1 2     Related To Testis-Specific, Vespid, And Pathogenesis Proteins 12
GliPR 12 3     Testes-Specific Vespid And Pathogenesis Protein 12

External Ids:    HGNC: 170011   Entrez Gene: 110102   Ensembl: ENSG000001392787   OMIM: 6026925   UniProtKB: P480603   

Export aliases for GLIPR1 gene to outside databases

Previous GC identifers: GC12P075591 GC12P074160 GC12P072924


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GLIPR1 Gene:
This gene encodes a protein with similarity to both the pathogenesis-related protein (PR) superfamily and the
cysteine-rich secretory protein (CRISP) family. Increased expression of this gene is associated with myelomocytic
differentiation in macrophage and decreased expression of this gene through gene methylation is associated with
prostate cancer. The protein has proapoptotic activities in prostate and bladder cancer cells. This gene is a
member of a cluster on chromosome 12 containing two other similar genes. Alternatively spliced variants which
encode different protein isoforms have been described; however, not all variants have been fully characterized.
(provided by RefSeq, Jul 2008)

GeneCards Summary for GLIPR1 Gene:
GLIPR1 (GLI pathogenesis-related 1) is a protein-coding gene. Diseases associated with GLIPR1 include glioblastoma multiforme, and prostate cancer. An important paralog of this gene is CLEC18B.

Gene Wiki entry for GLIPR1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the GLIPR1 gene promoter:
         TBP   HFH-3   p53   NCX/Ncx   AP-4   IRF-1   C/EBPalpha   FOXI1   TFIID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGLIPR1 promoter sequence
   Search Chromatin IP Primers for GLIPR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GLIPR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q21.2   Ensembl cytogenetic band:  12q21.2   HGNC cytogenetic band: 12q14.1

GLIPR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GLIPR1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P075800:  view genomic region     (about GC identifiers)

Start:
75,874,460 bp from pter      End:
75,897,633 bp from pter
Size:
23,174 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: GLIP1_HUMAN, P48060 (See protein sequence)
Recommended Name: Glioma pathogenesis-related protein 1 precursor  
Size: 266 amino acids; 30366 Da
Sequence caution: Sequence=AAA82731.3; Type=Frameshift; Positions=3;
2 PDB 3D structures from and Proteopedia for GLIPR1:
3Q2R (3D)        3Q2U (3D)    
Secondary accessions: A7YET6 F8VUC2 Q15409 Q969K2
Alternative splicing: 2 isoforms:  P48060-1   P48060-2   (Highly expressed in glioblastomas)

Explore the universe of human proteins at neXtProt for GLIPR1: NX_P48060

Explore proteomics data for GLIPR1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See GLIPR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006842.2  
    ENSEMBL proteins: 
     ENSP00000266659   ENSP00000440595   ENSP00000391144   ENSP00000448008  
    Reactome Protein details: P48060

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR014044 CAP_domain
     IPR001283 Allrgn_V5/Tpx1
     IPR002413 V5_allergen
     IPR018244 Allrgn_V5/Tpx1_CS

    Graphical View of Domain Structure for InterPro Entry P48060

    ProtoNet protein and cluster: P48060

    1 Blocks protein domain: IPB001283 Allergen V5/Tpx-1 related

    UniProtKB/Swiss-Prot: GLIP1_HUMAN, P48060
    Similarity: Belongs to the CRISP family
    Similarity: Contains 1 SCP domain


    Find genes that share domains with GLIPR1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         1 GenomeRNAi human phenotype for GLIPR1:
     Synthetic lethal with imatinib 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Glipr1):
     cellular  tumorigenesis 

    Find genes that share phenotypes with GLIPR1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Glipr1tm1Tt for GLIPR1

       genOway: Develop your customized and physiologically relevant rodent model for GLIPR1

    miRNA
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    miRTarBase miRNAs that target GLIPR1:
    hsa-mir-30a-5p (MIRT028463), hsa-mir-155-5p (MIRT020639)

    Block miRNA regulation of human, mouse, rat GLIPR1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GLIPR1 (see all 26):
    hsa-miR-548j hsa-miR-125a-5p hsa-miR-361-5p hsa-miR-548i hsa-miR-376b hsa-miR-340 hsa-miR-3167 hsa-miR-3658
    SwitchGear 3'UTR luciferase reporter plasmidGLIPR1 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GLIP1_HUMAN, P48060: Membrane; Single-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    extracellular2
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with GLIPR1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GLIPR1 About    
    See pathways by source

    SuperPathContained pathways About
    1Fatty acid, triacylglycerol, and ketone body metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism0.65
    PPARA Activates Gene Expression0.63
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)0.65
    2Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37


    Find genes that share SuperPaths with GLIPR1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for GLIPR1
        PPARA activates gene expression


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GLIPR1
    Interactions:

        GeneGlobe Interaction Network for GLIPR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for GLIPR1 (ENSP000002666594) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CARM1ENSP000003256904STRING: ENSP00000325690
    CHD9ENSP000003815224STRING: ENSP00000381522
    CREBBPENSP000002623674STRING: ENSP00000262367
    NCOA2ENSP000003999684STRING: ENSP00000399968
    NCOA6ENSP000003518944STRING: ENSP00000351894
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0044255cellular lipid metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--

    Find genes that share ontologies with GLIPR1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GLIPR1 (GLIP1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GLIPR1 gene: 
    NM_006851.2  

    Unigene Cluster for GLIPR1:

    GLI pathogenesis-related 1
    Hs.205558  [show with all ESTs]
    Unigene Representative Sequence: NM_006851
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000266659(uc009zsb.1 uc001sxs.3) ENST00000536703 ENST00000456650
    ENST00000550491
    miRNA
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    Block miRNA regulation of human, mouse, rat GLIPR1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GLIPR1 (see all 26):
    hsa-miR-548j hsa-miR-125a-5p hsa-miR-361-5p hsa-miR-548i hsa-miR-376b hsa-miR-340 hsa-miR-3167 hsa-miR-3658
    SwitchGear 3'UTR luciferase reporter plasmidGLIPR1 3' UTR sequence
    Inhib. RNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GLIPR1
      QuantiTect SYBR Green Assays in human, mouse, rat GLIPR1
      QuantiFast Probe-based Assays in human, mouse, rat GLIPR1

    Additional mRNA sequence: 

    AF400440.1 AK304847.1 AK313449.1 BC005227.1 BC012510.1 EF667354.1 U16307.3 X91911.1 

    11 DOTS entries:

    DT.100816382  DT.214853  DT.86840356  DT.100816390  DT.91778207  DT.91778222  DT.452949  DT.91778234 
    DT.101963524  DT.95340793  DT.95296134 

    Selected AceView cDNA sequences (see all 231):

    BQ012489 BU627879 AW103856 BU621195 AW139289 BI908468 AA721239 BM999460 
    BG573121 AA890085 CN481199 AA687383 CA489392 BP364676 BQ007544 CF126226 
    AU279933 CN485320 CB131168 BQ010189 AW263309 CF131083 AI086682 BF438702 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GLIPR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCCAGCAAT
    GLIPR1 Expression
    About this image


    GLIPR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Line H9 (Naive)
     
     Epithelial Cells
             Duct Cells Pancreatic Ducts
     
     NULL (Uncategorized)
             CD31, CD144 positive cells
     
     Bone (Muscoskeletal System)
             TGFbeta3+BMP7-induced chondrocytes
     
     Cartilage (Muscoskeletal System)
             TGFbeta3+BMP7-induced chondrocytes
    GLIPR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GLIPR1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.205558

    UniProtKB/Swiss-Prot: GLIP1_HUMAN, P48060
    Tissue specificity: According to PubMed:8973356, it is ubiquitously expressed with high levels in lung and kidney
    and low levels in heart and liver. Highly expressed in cell lines derived from nervous system tumors arising from
    glia, low or absent in non-glial-derived nervous system tumor cell lines. Also found in fetal kidney. According
    to PubMed:7607567 it is expressed only in brain tumor glioblastoma multiforme/astrocytoma and not in other
    nervous system tumors or normal fetal or adult tissues

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for GLIPR1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Glipr11 , 5 GLI pathogenesis-related 1 (glioma)1, 5 78.82(n)1
    71.76(a)1
      10 (59.98 cM)5
    736901  NM_028608.31  NP_082884.11 
     1119854555 
    chicken
    (Gallus gallus)
    Aves GLIPR11 GLI pathogenesis-related 1 (glioma) 66.51(n)
    57.67(a)
      427869  XM_004937576.1  XP_004937633.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    46(a)
    45(a)
    1 ↔ many
    1 ↔ many
    5(40368179-40377729)
    5(40356655-40363964)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1018868461 glioma pathogenesis-related protein 1-like 54.51(n)
    48.5(a)
      101886846  XM_005164464.1  XP_005164521.1 
    worm
    (Caenorhabditis elegans)
    Secernentea scl-56
    scl-76
    (see all 19)
    Protein SCL-7 (scl-7) mRNA, complete cds
    (see all 19)
    30(a)
    29(a)
    (see all 19)
    many ↔ many
    many ↔ many
    (see all 19)
    IV(13064004-13065158) WBGene00008027
    IV(13070479-13071270) WBGene00008029


    ENSEMBL Gene Tree for GLIPR1 (if available)
    TreeFam Gene Tree for GLIPR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GLIPR1 gene
    CLEC18B2  CRISPLD22  CLEC18C2  PI162  CRISP22  PI152  CRISP12  CRISPLD12  
    CRISP32  GLIPR1L12  CLEC18A2  GLIPR1L22  R3HDML2  
    7 SIMAP similar genes for GLIPR1 using alignment to 4 protein entries:     GLIP1_HUMAN (see all proteins):
    GLIPR1L1    GLIPR1L2    PI16    CRISP2    CRISP3    PI15
    CRISP1

    Find genes that share paralogs with GLIPR1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GLIPR1 (see all 430)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1391000301,2
    Cuntested175875825(+) GACTCG/AGATAT 2 /Q /R mis11Minor allele frequency- A:0.00NA 4550
    rs675996161,2
    C--75736859(+) TTTTG-/T/TG  
            
    TTTTT
    1 -- int10--------
    rs1173223451,2
    C,F--75872533(+) TGCCTA/GTGAGA 1 -- us2k11Minor allele frequency- G:0.03NA 120
    rs1825423291,2
    --75872691(+) TCTGTA/GATGGT 1 -- us2k10--------
    rs2017783601,2
    C--75872698(+) ATGGT-/TTTG  
            
    TTGTT
    1 -- us2k10--------
    rs794230321,2
    C,F--75872706(+) GTTTGT/GTTGGT 1 -- us2k13Minor allele frequency- G:0.08WA CSA 122
    rs1423609801,2
    C--75872797(+) ACTCCA/GCCTCC 1 -- us2k10--------
    rs1872562561,2
    --75872828(+) GCCTCA/GGCCTC 1 -- us2k10--------
    rs1432373221,2
    --75872832(+) CAGCCA/TCGCAA 1 -- us2k10--------
    rs1512856861,2
    --75872954(+) GATCCA/GCCCTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for GLIPR1 (75874460 - 75897633 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for GLIPR1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv273819CNV Insertion20981092
    nsv899313CNV Gain21882294
    nsv826439CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602692    OMIM disorders: --

    2 diseases for GLIPR1:    
    About MalaCards
    glioblastoma multiforme    prostate cancer


    Find genes that share disorders with GLIPR1           About GenesLikeMe

    5 Novoseek inferred disease relationships for GLIPR1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nervous system tumor 82.2 3 7607567 (1), 8973356 (1)
    glioma 61.6 8 9583595 (2), 9482873 (2), 19483285 (1), 18199537 (1) (see all 5)
    glioblastoma multiforme 54.4 2 7607567 (1), 9482873 (1)
    brain tumors 37.6 1 8973356 (1)
    tumors 9.27 18 18199537 (4), 14871827 (2), 20499410 (1), 8973356 (1) (see all 5)

    Genetic Association Database (GAD): GLIPR1
    Human Genome Epidemiology (HuGE) Navigator: GLIPR1 (4 documents)

    Export disorders for GLIPR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GLIPR1 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with GLIPR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. RTVP-1, a novel human gene with sequence similarity to genes of diverse species, is expressed in tumor cell lines of glial but not neuronal origin. (PubMed id 8973356)1, 2, 3, 9 Rich T.... Israel M.A. (Gene 1996)
    2. The human glioma pathogenesis-related protein is structurally related to plant pathogenesis-related proteins and its gene is expressed specifically in brain tumors. (PubMed id 7607567)1, 2, 3, 9 Murphy E.V.... Biggs J. (Gene 1995)
    3. Structure comparison of human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein P14a indicates a functional link between the human immune system and a plant defense system. (PubMed id 9482873)1, 2, 9 Szyperski T.... Wuethrich K. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. Cloning and characterization of human RTVP-1b, a novel splice variant of RTVP-1 in glioma cells. (PubMed id 17825796)1, 2 Xiang C.... Brodie C. (Biochem. Biophys. Res. Commun. 2007)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. [Methylation and expression of glioma pathogenesis-related protein 1 gene in acute myeloid leukemia]. (PubMed id 19483285)1, 9 Liang T....Xiao Z. (Zhong Nan Da Xue Xue Bao Yi Xue Ban 2009)
    8. Glioma pathogenesis-related protein 1 exerts tumor suppressor activities through proapoptotic reactive oxygen species-c-Jun-NH2 kinase signaling. (PubMed id 18199537)1, 9 Li L....Thompson T.C. (Cancer Res. 2008)
    9. Identification and characterization of RTVP1/GLIPR1-like genes, a novel p53 target gene cluster. (PubMed id 16714093)1, 9 Ren C.... Thompson T.C. (Genomics 2006)
    10. RTVP-1, a tumor suppressor inactivated by methylation in prostate cancer. (PubMed id 14871827)1, 9 Ren C....Thompson T.C. (Cancer Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11010 HGNC: 17001 AceView: GLIPR1 Ensembl:ENSG00000139278 euGenes: HUgn11010
    ECgene: GLIPR1 H-InvDB: GLIPR1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GLIPR1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GLIPR1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GLIPR1 gene:
    Search GeneIP for patents involving GLIPR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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