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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GLI4 Gene

protein-coding   GIFtS: 44
GCID: GC08P144349

GLI Family Zinc Finger 4

(Previous names: GLI-Kruppel family member GLI4, glioma-associated oncogene...)
  Search for GLI4
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
GLI Family Zinc Finger 41 2     ZNF9282
HKR42 3 5     GLI-Kruppel Family Member GLI4 (Oncogene HKR4)2
Glioma-Associated Oncogene Family Zinc Finger 41 2     Zinc Finger Protein GLI42
Krueppel-Related Zinc Finger Protein 42 3     Protein HKR43
GLI-Kruppel Family Member GLI41     

External Ids:    HGNC: 43201   Entrez Gene: 27382   Ensembl: ENSG000002505717   OMIM: 1652805   UniProtKB: P100753   

Export aliases for GLI4 gene to outside databases

Previous GC identifers: GC08P142542 GC08P9D0066 GC08P144104 GC08P144402 GC08P144420 GC08P144329 GC08P139603


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for GLI4 Gene: 
GLI4 (GLI family zinc finger 4) is a protein-coding gene. GO annotations related to this gene include DNA binding and molecular_function. An important paralog of this gene is ZFP41.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_008046.16  NC_018919.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GLI4 gene promoter:
         GR   Bach1   GR-beta   Bach2   Olf-1   STAT5A   NF-E2 p45   AREB6   GR-alpha   NF-E2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for GLI4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GLI4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.3   Ensembl cytogenetic band:  8q24.3   HGNC cytogenetic band: 8q24.3

GLI4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GLI4 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P144349:  view genomic region     (about GC identifiers)

Start:
144,349,603 bp from pter      End:
144,359,101 bp from pter
Size:
9,499 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GLI4_HUMAN, P10075 (See protein sequence)
Recommended Name: Zinc finger protein GLI4  
Size: 376 amino acids; 41145 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: Q96CK9

Explore the universe of human proteins at neXtProt for GLI4: NX_P10075

Explore proteomics data for GLI4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P10075

  • GLI4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GLI4 Protein Expression
    REFSEQ proteins: NP_612474.1  
    ENSEMBL proteins: 
     ENSP00000430292   ENSP00000344727   ENSP00000429295   ENSP00000430987   ENSP00000427881  
     ENSP00000429514   ENSP00000345024  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS--

    GLI4 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry P10075

    ProtoNet protein and cluster: P10075

    1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: GLI4_HUMAN, P10075
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 7 C2H2-type zinc fingers


    GLI4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:
         Genatlas biochemistry entry for GLI4:
    GLI-Kruppel family member GLI4

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    GLI4 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for GLI4:
     Actin fiber cells  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for GLI4 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GLI4

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    GLI4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GLI4

    Search CenterWatch for drugs/clinical trials and news about GLI4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GLI4 gene: 
    NM_138465.3  

    Unigene Cluster for GLI4:

    GLI family zinc finger 4
    Hs.400533  [show with all ESTs]
    Unigene Representative Sequence: NM_138465
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000519876 ENST00000522479 ENST00000521682 ENST00000344692 ENST00000517468
    ENST00000523522 ENST00000520021 ENST00000517530 ENST00000522033 ENST00000523812
    ENST00000340042(uc003yxx.3)
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    Additional mRNA sequence: BC014165.2 

    5 DOTS entries:

    DT.431707  DT.99994741  DT.120633795  DT.95263472  DT.95248218 

    24/184 AceView cDNA sequences (see all 184):

    BQ574941 BM931804 AI803226 AW500196 CA488695 AW299994 BE465758 BF064174 
    AI763124 AI432630 AW137506 AI424303 H61808 AI498703 AI597688 BF805447 
    NM_138465 CR621152 AL831951 BF593488 BG222826 BM727950 BE646304 AI829114 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GLI4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCACGTGTCC
    GLI4 Expression
    About this image


    See GLI4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GLI4

    SOURCE GeneReport for Unigene cluster: Hs.400533
        SABiosciences Custom PCR Arrays for GLI4
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GLI4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for GLI4 gene from 1/5 species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    rat
    (Rattus norvegicus)
    Mammalia Gli41 GLI family zinc finger 4 77.08(n)
    72.55(a)
      500893  NM_001029926.1  NP_001025097.1 


    ENSEMBL Gene Tree for GLI4 (if available)
    TreeFam Gene Tree for GLI4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GLI4 gene
    ZFP412  ZNF6962  ENSG000002646682  
    18/490 SIMAP similar genes for GLI4 using alignment to 6 protein entries:     GLI4_HUMAN (see all proteins) (see all similar genes):
    DKFZp761O1618    ZNF232    ZNF566    DKFZp547L155    ZFP3    ZNF16
    ZNF383    HZF36    ZNF19    ZNF286A    ZNF286B    ZNF619
    ZNF620    DKFZp686K03205    ZFP1    ZFP28    ZNF287    ZNF551

    GLI4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/312 SNPs in GLI4 are shown (see all 312)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1391241451,2
    --144347632(+) ACTTGA/GGAGGC 1 -- us2k10--------
    rs1891412571,2
    --144347680(+) TTGCAG/TTGAGC 1 -- us2k10--------
    rs1810738471,2
    --144347686(+) TGAGCC/TGAGAT 1 -- us2k10--------
    rs1128299391,2
    C,F--144347771(+) TTTGCC/TTGGCT 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1863714811,2
    --144348099(+) AGATAC/TAGTAC 1 -- us2k10--------
    rs360204121,2
    C--144348131(+) TTTTT-/T/TT  
            
    GAGAC
    1 -- us2k11NA 2
    rs73880451,2
    C,F--144348189(+) gcgcaC/Atgcaa 1 -- us2k14Minor allele frequency- A:0.38NA WA CSA 8
    rs119965161,2
    C,F,A,H--144348350(+) cctctG/Tgtgat 1 -- us2k12Minor allele frequency- T:0.15CSA WA 120
    rs119965171,2
    C,F,A,H--144348351(+) ctctgG/Ttgatc 1 -- us2k12Minor allele frequency- T:0.15CSA WA 120
    rs1911741401,2
    --144348356(+) GTGATC/GCACCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for GLI4 (144349603 - 144359101 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/13 variations for GLI4 (see all 13):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2737983CNV Deletion23290073
    dgv1289e201CNV Deletion23290073
    esv2737988CNV Deletion23290073
    esv2737986CNV Deletion23290073
    esv2737987CNV Deletion23290073
    dgv7921n71CNV Loss21882294
    dgv7920n71CNV Loss21882294
    dgv7922n71CNV Loss21882294
    nsv891671CNV Loss21882294
    nsv891660CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    GLI4 for disorders           About MalaCards
    OMIM gene information: 165280    OMIM disorders: --


    GLI4 for disorders           About GeneDecksing


    Export disorders for GLI4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GLI4 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with GLI4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The GLI-Kruppel family of human genes. (PubMed id 2850480)1, 2, 3 Ruppert J.M.... Vogelstein B. (1988)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Assignment of the gene encoding human Kruppel-related zinc finger protein 4 (GLI4) to 8q24.3 by fluorescent in situ hybridization. (PubMed id 8641133)1, 9 Kas K....Van de Ven W.J. (1996)
    4. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (2009)
    5. Large-scale proteomics analysis of the human kinome. (PubMed id 19369195)2 Oppermann F.S.... Daub H. (2009)
    6. Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (2008)
    7. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    8. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1 Olsen J.V....Mann M. (2006)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2738 HGNC: 4320 AceView: GLI4andFLJ38705 Ensembl:ENSG00000250571 euGenes: HUgn2738
    ECgene: GLI4 H-InvDB: GLI4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GLI4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GLI4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GLI4 gene:
    Search GeneIP for patents involving GLI4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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