GLI4 Gene
protein-coding GIFtS: 41
GCID: GC08P144349
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GLI family zinc finger 4(Previous names: GLI-Kruppel family member GLI4, glioma-associated oncogene...)
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Aliases
for GLI4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| GLI Family Zinc Finger 41 2 | | GLI-Kruppel Family Member GLI41 | | HKR41 2 3 5 | | GLI-Kruppel Family Member GLI4 (Oncogene HKR4)2 | | ZNF9281 2 | | Zinc Finger Protein GLI42 | | Glioma-Associated Oncogene Family Zinc Finger 41 2 | | Protein HKR43 | | Krueppel-Related Zinc Finger Protein 42 3 | | |
Export aliases for GLI4 gene to outside databasesPrevious GC identifers: GC08P142542 GC08P9D0066 GC08P144104 GC08P144402 GC08P144420 GC08P144329 GC08P139603 |
Summaries
for GLI4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for GLI4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_008046.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the GLI4 gene promoter:
GR Bach1 GR-beta Bach2 Olf-1 STAT5A NF-E2 p45 AREB6 GR-alpha NF-E2
Other transcription factors
Search SABiosciences Chromatin IP Primers for GLI4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GLI4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q24.3 Ensembl cytogenetic band: 8q24.3 HGNC cytogenetic band: 8q24.3GLI4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08P144349: view genomic region
(about GC identifiers)
Start:
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144,349,603 bp from pter |
End:
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144,359,101 bp from pter |
Size:
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9,499 bases |
Orientation:
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plus strand |
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Proteins
for GLI4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: GLI4_HUMAN, P10075 (See
protein sequence)Recommended Name: Zinc finger protein GLI4 Size: 376 amino acids; 41145 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: Q96CK9Explore the universe of human proteins at neXtProt for GLI4: NX_P10075
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P10075
GLI4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_612474.1
ENSEMBL proteins: ENSP00000430292 ENSP00000344727 ENSP00000429295 ENSP00000430987 ENSP00000427881 ENSP00000429514 ENSP00000345024
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0005634 | nucleus |
NAS | -- |
GLI4 for ontologies About GeneDecksing
GLI4 Antibody Products:
Assay Products for GLI4: |
Protein
Domains /
Families
for GLI4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GLI4 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P10075ProtoNet protein and cluster: P10075 1 Blocks protein family: IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: GLI4_HUMAN, P10075Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 7 C2H2-type zinc fingers |
Function
for GLI4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Function Summary:
Genatlas biochemistry entry for GLI4:GLI-Kruppel family member GLI4
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GLI4
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GLI4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: GLI4 (NM_138465) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GLI4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GLI4 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
GLI4 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for GLI4:
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Pathways & Interactions
for GLI4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GLI4
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0008150 | biological_process |
ND | -- |
GLI4 for ontologies About GeneDecksing
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Drugs & Compounds
for GLI4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for GLI4
Search CenterWatch for drugs/clinical trials and news about GLI4
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Transcripts
for GLI4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for GLI4 gene: NM_138465.3 Unigene Cluster for GLI4: GLI family zinc finger 4 Hs.400533 [show with all ESTs]Unigene Representative Sequence: NM_13846511 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000519876 ENST00000522479 ENST00000521682 ENST00000344692 ENST00000517468
ENST00000523522 ENST00000520021 ENST00000517530 ENST00000522033 ENST00000523812
ENST00000340042(uc003yxx.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GLI4
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GLI4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: GLI4 (NM_138465) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GLI4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GLI4 |
Additional cDNA sequence: BC014165.2 5 DOTS entries: DT.431707 DT.99994741 DT.120633795 DT.95263472 DT.95248218 24/184 AceView cDNA sequences (see all 184): BF593488 BG222826 BF805447 BF064174 BM727950 BE465758 AW137506 CA488695 BQ574941 AI597688 AI763124 AI498703 AI803226 AW299994 NM_138465 CR621152 BM931804 H61808 AI424303 BE646304 AW500196 AI432630 AL831951 AI829114
GeneLoc Exon Structure
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Expression
for GLI4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| GLI4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCACGTGTCC
About this image
See GLI4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GLI4
SOURCE GeneReport for Unigene cluster: Hs.400533
SABiosciences Custom PCR Arrays for GLI4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GLI4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat GLI4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GLI4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GLI4 |
Orthologs
for GLI4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of chordates.
Orthologs for GLI4 gene from 1/6 species (see all 6) About this table
ENSEMBL Gene Tree for GLI4 (if available)
TreeFam Gene Tree for GLI4 (if available) |
Paralogs
for GLI4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for GLI4 gene
- ZNF6962
18/486 SIMAP similar genes for GLI4 using alignment to 6 protein entries: GLI4_HUMAN (see all proteins)
(see all similar genes):DKFZp761O1618 ZNF232 ZNF566 DKFZp547L155 ZFP3 ZNF16
ZNF383 ZNF551 HZF36 ZNF19 ZNF286A ZNF286B
ZNF619 ZNF620 DKFZp686K03205 ZFP1 ZFP28 ZNF287
GLI4 for paralogs About GeneDecksing
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Genomic Variants
for GLI4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for GLI4 (144349603 - 144359101 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for GLI4: -- | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for GLI4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 GLI4 for disorders About MalaCards
GLI4 for disorders About GeneDecksing
OMIM gene information: 165280
OMIM disorders: --
Export disorders for GLI4 gene to outside databases
|
Publications
for GLI4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for GLI4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with GLI4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The GLI-Kruppel family of human genes. (PubMed id 2850480)1, 2, 3 Ruppert J.M.... Vogelstein B. (1988)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Assignment of the gene encoding human Kruppel-related zinc finger protein 4 (GLI4) to 8q24.3 by fluorescent in situ hybridization. (PubMed id 8641133)1, 9 Kas K....Van de Ven W.J. (1996)
- Large-scale proteomics analysis of the human kinome. (PubMed id 19369195)2 Oppermann F.S.... Daub H. (2009)
- Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (2008)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1 Olsen J.V....Mann M. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (2001)
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External Searches for GLI4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing GLI4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing GLI4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GLI4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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About This Section
| Patent Information for GLI4 gene:
Search GeneIP for patents involving GLI4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for GLI4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for GLI4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GLI4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GLI4 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for GLI4 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GLI4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GLI4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for GLI4 | | OriGene Custom Protein Services for GLI4 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GLI4 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GLI4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GLI4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GLI4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GLI4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GLI4 |
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| | | | Search Tocris compounds for GLI4 |
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 | | | GLI4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for GLI4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GLI4 |
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