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GLI2 Gene

protein-coding GIFtS: 68

GC02P121266

GLI family zinc finger 2
(Previous names: GLI-Kruppel family member GLI2, glioma-associated oncogene family zinc finger 2 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
HPE9 ^¹, ², ⁵
THP ^³
THP1 ^¹, ²
THP2 ^¹, ²

Descriptions
GLI family zinc finger 2 ^²
GLI-Kruppel family member GLI2 ^¹, ²
Tax helper protein ^³
glioma-associated oncogene family zinc finger 2 ^¹, ²
oncogene GLI2 ^²
tax helper protein 1 ^²
tax helper protein 2 ^²
tax-responsive element-2 holding protein ^²
tax-responsive element-25-bp sequence binding protein ^²
zinc finger protein GLI2 ^²

External Ids
HGNC: 4318¹
Entrez Gene: 2736²
UniProtKB: P10070³
Ensembl: ENSG00000074047⁷

Search outside databases for aliases for GLI2 gene

Previous GC identifers: GC02P118754 GC02P119470 GC02P121456 GC02P121645

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for GLI2:

This gene encodes a protein which belongs to the C2H2-type zinc finger protein subclass of the Gli

family. Members of this subclass are characterized as transcription factors which bind DNA through

zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are

mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the

embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and

activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role

during embryogenesis. The encoded protein is associated with several phenotypes- Greig

cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial

polydactyly types A1 and B. [provided by RefSeq]

UniProtKB/Swiss-Prot: GLI2_HUMAN, P10070

Function: May play a role during embryogenesis. Binds to the DNA sequence 5'-GAACCACCCA-3' which is

part of the TRE-2S regulatory element that augments the Tax-dependent enhancer of human T-cell

leukemia virus type 1. Implicated in the transduction of SHH signal

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the GLI2 gene

Entrez Gene cytogenetic band: 2q14 Ensembl cytogenetic band: 2q14.2 HGNC cytogenetic band: 2q14

GLI2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P121266: (about GC identifiers)

Start:	121,266,327 bp from pter
End:	121,466,321 bp from pter
Size:	199,995 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000002.10 NT_022135.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: GLI2_HUMAN, P10070 (See protein sequence)

Recommended Name: Zinc finger protein GLI2

Size: 1586 amino acids; 167783 Da

Subcellular location: Nucleus (Potential)

Sequence caution: Sequence=BAA03568.1; Type=Frameshift; Positions=754, 760; Sequence=BAA03569.1;

Type=Frameshift; Positions=398, 410, 754, 760; Sequence=BAA25665.1; Type=Frameshift;

Positions=398, 410; Sequence=BAA25667.1; Type=Frameshift; Positions=398, 410;

Secondary accessions: O60252 O60253 O60254 O60255 Q15590 Q15591 Q4JHT4

Alternative splicing: 5 isoforms: P10070-5 P10070-1 P10070-2 P10070-3 P10070-4

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_005261.2

ENSEMBL proteins:

ENSP00000354586 ENSP00000354122 ENSP00000344473 ENSP00000312694

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Gli2)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005634	nucleus	IEA	--

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Antibodies for GLI2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for GLI2
	R&D Systems Antibodies for GLI2 (GLI-2)
	Cell Signaling Technology (CST) Antibodies for GLI2
	Antibodies from Abcam (Gli2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (GLI2)
	Novus Biologicals Antibodies for GLI2

Assays for GLI2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P10070

ProtoNet protein and cluster: P10070

1 Blocks protein family: IPB007086 C2H2-type zinc finger signature

UniProtKB/Swiss-Prot: GLI2_HUMAN, P10070

Similarity: Belongs to the GLI C2H2-type zinc-finger protein family

Similarity: Contains 5 C2H2-type zinc fingers

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GLI2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_030379

Applied Biosystems Silencer® siRNAs for GLI2

Sigma-Aldrich siRNA for GLI2

Sigma-Aldrich shRNA for GLI2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_005270
Myc/DDK tagged cDNA clone in CMV expression vector: NM_005270
untagged cDNA clones in CMV expression vector (see all 2): NM_005270

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005270

UniProtKB/Swiss-Prot: GLI2_HUMAN, P10070

Function: May play a role during embryogenesis. Binds to the DNA sequence 5'-GAACCACCCA-3' which is

part of the TRE-2S regulatory element that augments the Tax-dependent enhancer of human T-cell

leukemia virus type 1. Implicated in the transduction of SHH signal

Genatlas biochemistry entry for GLI2:

GLI-Kruppel family member GLI2,with homology to Drosophila segment polarity gene Cubitus

interruptus,involved in the formation of lung,trachea and oesophagus

15/21 MGI mutant phenotypes (inferred from 12 alleles) (MGI details for Gli2) (see all 21 ):

behavior/neurological	cellular	craniofacial	digestive/alimentary	embryogenesis
endocrine/exocrine gland	growth/size	hearing/vestibular/ear	homeostasis/metabolism	lethality-postnatal
lethality-prenatal/perinatal	life span-post-weaning/aging	limbs/digits/tail	nervous system	no phenotypic analysis

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	IDA	15994174
GO:0008270	zinc ion binding	IDA	8378770
GO:0016563	transcription activator activity	IDA	15175043
GO:0043565	sequence-specific DNA binding	IDA	9557682 15175043
GO:0046872	metal ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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4 Sigma-Aldrich "Your Favorite Gene" Pathways for GLI2 (Your Favorite Gene powered by Ingenuity)

Axonal Guidance Signaling
Basal Cell Carcinoma Signaling
Sonic Hedgehog Signaling
Corticotropin Releasing Hormone Signaling

GeneDecks GLI2 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for GLI2

5/56 Interacting proteins for GLI2 (ENSP00000354586³) via UniProtKB, MINT, and/or STRING (see all 56 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SHH	ENSP00000297261³	STRING (score=.999)
SUFU	ENSP00000358918³	STRING (score=.998)
SMO	ENSP00000249373³	STRING (score=.992)
BTRC	ENSP00000359206³	STRING (score=.987)
STK36	ENSP00000295709³	STRING (score=.983)

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5/32 Gene Ontology (GO) biological process terms (links to tree view) (see all 32 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IMP	15994174
GO:0001501	skeletal system development	ISS	--
GO:0001822	kidney development	ISS	--
GO:0002076	osteoblast development	ISS	--
GO:0006350	transcription	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for GLI2

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for GLI2
1 Novoseek chemical compound relationship for GLI2 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
zinc	46.81	7	15520176 (2), 10769232 (1), 15140221 (1), 9557682 (1) (see all 6)

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GLI2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_030379

Sigma-Aldrich siRNA for GLI2

Sigma-Aldrich shRNA for GLI2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005270

REFSEQ mRNAs for GLI2 gene:

NM_005270.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_005270

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005270
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_005270
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_005270

Additional cDNA sequence:

AB007295.1 AB007297.1 AB209354.1 AK300071.1 AY493737.1 AY493738.1 AY493739.1 BC111410.1

DQ004396.1 DQ004397.1 DQ004398.1 DQ086814.1

5 DOTS entries:

DT.92418615 DT.102829768 DT.40113400 DT.441245 DT.95266956

24/42 AceView cDNA sequences (see all 42 ):

AI822132 N75386 AA620825 W79695 W01898 CA430900 AY493739 AW089214

AI089685 AI379285 AI204540 AW964168 AY493737 NM_030381 D14827 D14828

NM_030379 BX103004 AA378649 AB007296 AB007297 AA375858 AI075849 AI797248

highest scoring ESTs for GLI2:

AA375858 AA378649 AB007295 AB007296 AB007297 AI797248 D14827 AA620825 AB007298 AB209354

Unigene Cluster for GLI2:

GLI family zinc finger 2

Hs.111867 [show with all ESTs]

Unigene Representative Sequence: NM_005270

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for GLI2 (see all 7 )

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7	^	8a	·	8b	^	9	^	10	^	11	^	12	^	13	^	14a	·	14b
SP1:
SP2:							-		-		-		-
SP3:							-		-		-		-								-
SP4:							-		-		-		-
SP5:							-		-		-		-								-

About this scheme

ECgene alternative splicing isoforms for GLI2

4 Ensembl transcripts including schematic representations:

ENST00000361492 ENST00000360874 ENST00000341310 ENST00000314490

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

GLI2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for GLI2

¹ / ² / ³

9 probe-sets matching GLI2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
34456_s_at²^{, 3}	U95-A	1	1.00	1.00	0.46	0.25	AB007296	0.80	1.00	0.91	1
1200_at²^{, 3}	U95-A	1	1.00	1.00	0.83	0.77	D14827	0.80	1.00	0.91	1
50974_at²^{, 3}	U95-B	1	1.00	1.00	0.25	1.24	AI797248	0.80	1.00	0.91	1
208057_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	D14827	0.80	1.00	0.91	1
228537_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI797248	0.80	1.00	0.91	1
207034_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_030379	0.40	1.00	0.76	1
208057_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
228537_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
207034_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CTCAACTTGT

SOURCE GeneReport for Unigene cluster: Hs.111867
Expression variation in blood from EXPOLDB for GLI2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for GLI2 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	GLI2¹	--	GLI-Kruppel family member GLI2	99.24(n) 99.5(a)	459582 XM_001158337.1 XP_001158337.1
cow (Bos taurus)	GLI2¹	--	GLI-Kruppel family member GLI2	86.33(n) 86.75(a)	510255 XM_587380.3 XP_587380.3
rat (Rattus norvegicus)	Gli2¹	--	GLI-Kruppel family member GLI2	82.51(n) 84.37(a)	304729 XM_222557.4 XP_222557.4
mouse (Mus musculus)	Gli2^{1, 5}	1 (63.00 cM)⁵	GLI-Kruppel family member GLI2^{1, 5}	82.67(n)¹ 85.15(a)¹	14633¹ NM_001081125.1¹ NP_001074594.1¹ AA798747⁵ AK051858⁵ (see all 21)
chicken (Gallus gallus)	GLI2¹	--	GLI-Kruppel family member GLI2	70.63(n) 69.87(a)	395956 XM_422086.2 XP_422086.2

About this table Species with no ortholog for GLI2

ENSEMBL Gene Tree for GLI2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for GLI2 gene

GLI3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/1265 NCBI SNPs in GLI2 are shown (see all 1265 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 482)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2278741^1,2	A,C,F,H,O	121465537(+)	`AAGAAC/GACTTG`	1	--	ut3¹		12	EA NA EU WA	2480
	rs11898679^1,2	A,C,F,H	121265347(+)	`AGCCCG/ACTTTG`	1	--	ng5¹		4	EU EA WA	410
--	rs12711538^1,2	A,C,F,H	121463876(+)	`TCCCCA/GATTCA`	1	D/N	mis¹ ese³		4	EU EA WA	408
	rs3738880^1,2	A,C,F,H	121463426(-)	`CAGGGA/CGTCTA`	1	A/S	mis¹ ese³		9	EA MN EU NA	2342
	rs13421765^1,2	C,F,H	121266467(+)	`ttaccG/Aacaca`	1	--	ut5¹		4	EU EA WA	418
	rs4848629^1,2	C,H	121266270(+)	`CAAGCC/AAGTCC`	1	--	ng5¹		4	EU EA WA	420
	rs13417667^1,2	F,H	121265024(+)	`GGGAAG/AGCTGA`	1	--	ng5¹		4	EU EA WA	418
	rs10200484^1,2	A,H	121265810(+)	`atgcaG/Agtgac`	1	--	ng5¹		4	EU EA WA	420
	rs13427953^1,2	H	121449132(+)	`AGTACG/CACACC`	1	H/D	mis¹ ese³		4	EU EA WA	382
	rs13417967^1,2	H	121265281(+)	`TTCAGG/AGTGGA`	1	--	ng5¹		4	EU EA WA	412

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HapMap Linkage Disequilibrium images for GLI2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 165230

UniProtKB/Swiss-Prot: GLI2_HUMAN, P10070

Defects in GLI2 are the cause of holoprosencephaly type 9 (HPE9) [MIM:610829]; also called

pituitary anomalies with holoprosencephaly-like features. The primary features of this disease

include defective anterior pituitary formation and pan-hypopituitarism, with or without overt

forebrain cleavage abnormalities, and holoprosencephaly-like midfacial hypoplasia.

Holoprosencephaly is the most common structural anomaly of the brain, in which the developing

forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is

genetically heterogeneous and associated with several distinct facies and phenotypic variability

8 Novoseek disease relationships for GLI2 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
leukemia t-cell	79.52	15	8617746 (1), 9847380 (1), 19129196 (1), 7745688 (1) (see all 11)
carcinoma basal cell	66.00	4	15175043 (1), 15140221 (1), 18264131 (1), 12786818 (1)
holoprosencephaly	63.87	1	17103456 (1)
skin tumor	29.83	2	12235001 (2)
hypoplasia	27.99	1	9731531 (1)
glioblastoma	27.38	1	12241103 (1)
cancer	17.53	3	17638910 (1), 19158486 (1), 15520176 (1)
tumors	8.37	15	18264131 (3), 15520176 (3), 12235001 (1), 15175043 (1) (see all 7)

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Human Gene Mutation Database: GLI2
Genetic Association Database: GLI2
Human Genome Epidemiology Navigator: GLI2 (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/104 PubMed articles for GLI2 gene (see all 104 ):

Cloning of novel isoforms of the human Gli2 oncogene and their activities to enhance tax-dependent transcription of the human T-cell leukemia virus type 1 genome. (PubMed id 9557682)^{1, 2, 3, 4} Tanimura A....Yoshida M. (1998)
Loss-of-function mutations in the human GLI2 gene are associated with pituitary anomalies and holoprosencephaly-like features. (PubMed id 14581620)^{3, 4, 6} Roessler E....Muenke M. (2003)
The GLI-Kruppel family of human genes. (PubMed id 2850480)^{2, 3, 4} Ruppert J.M.... Vogelstein B. (1988)
A previously unidentified amino-terminal domain regulates transcriptional activity of wild-type and disease-associated human GLI2. (PubMed id 15994174)^{1, 3, 4} Roessler E.... Muenke M. (2005)
A new regulatory element that augments the Tax-dependent enhancer of human T-cell leukemia virus type 1 and cloning of cDNAs encoding its binding proteins. (PubMed id 8350401)^{1, 3, 4} Tanimura A.... Yoshida M. (1993)
Medical sequencing of candidate genes for nonsyndromic cleft lip and palate. (PubMed id 16327884)^{3, 6} Vieira A.R....Murray J.C. (2005)
Gli2 upregulates cFlip and renders basal cell carcinoma cells resistant to death ligand-mediated apoptosis. (PubMed id 18264131)^{1, 3} Kump E....Erb P. (2008)
GLI2 is expressed in normal human epidermis and BCC and induces GLI1 expression by binding to its promoter. (PubMed id 15175043)^{1, 3} Ikram M.S....Philpott M. (2004)
Interaction of Gli2 with CREB protein on DNA elements in the long terminal repeat of human T-cell leukemia virus type 1 is responsible for transcriptional activation by tax protein. (PubMed id 10074179)^{1, 3} Dan S....Yoshida M. (1999)
Induction of sonic hedgehog mediators by transforming growth factor-beta: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivo. (PubMed id 17638910)^{1, 3} Dennler S....Mauviel A. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 2736	HGNC: 4318	AceView: GLI2	Ensembl:ENSG00000074047	euGenes: HUgn2736
ECgene: GLI2	H-InvDB: GLI2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for GLI2	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for GLI2
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for GLI2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
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Antibodies for GLI2

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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GLI2 Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for GLI2

Summaries
for GLI2

Genomic Location
for GLI2

Proteins
for GLI2

Protein Domains/
Families
for GLI2

Gene Function
for GLI2

Pathways & Interactions
for GLI2

Drugs & Compounds
for GLI2

Transcripts
for GLI2

Expression
for GLI2

Orthologs
for GLI2

Paralogs
for GLI2

SNPs/Variants
for GLI2

Disorders & Mutations
for GLI2

Medical News
for GLI2

Publications
for GLI2

Search for GLI2

Genome Databases showing GLI2

Other Databases showing GLI2

Specialized Databases showing GLI2

Licensable Technologies
for GLI2

Services
for GLI2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

GLI2 Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor GLI2

Summariesfor GLI2

Genomic Locationfor GLI2

Proteinsfor GLI2

Protein Domains/Familiesfor GLI2

Gene Functionfor GLI2

Pathways & Interactionsfor GLI2

Drugs & Compoundsfor GLI2

Transcriptsfor GLI2

Expression for GLI2

Orthologsfor GLI2

Paralogsfor GLI2

SNPs/Variantsfor GLI2

Disorders & Mutationsfor GLI2

Medical Newsfor GLI2

Publicationsfor GLI2

Search for GLI2

Genome Databases showing GLI2

Other Databases showing GLI2

Specialized Databases showing GLI2

Licensable Technologiesfor GLI2

Servicesfor GLI2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for GLI2

Summaries
for GLI2

Genomic Location
for GLI2

Proteins
for GLI2

Protein Domains/
Families
for GLI2

Gene Function
for GLI2

Pathways & Interactions
for GLI2

Drugs & Compounds
for GLI2

Transcripts
for GLI2

Expression
for GLI2

Orthologs
for GLI2

Paralogs
for GLI2

SNPs/Variants
for GLI2

Disorders & Mutations
for GLI2

Medical News
for GLI2

Publications
for GLI2

Licensable Technologies
for GLI2

Services
for GLI2