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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GLI1 Gene

protein-coding   GIFtS: 67
GCID: GC12P057853

GLI family zinc finger 1

(Previous names: glioma-associated oncogene homolog 1 (zinc finger protein),...)
(Previous symbol: GLI)
 Explore 78 diseases affiliated with
GLI1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for GLI1    

Aliases
for GLI1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
GLI Family Zinc Finger 11 2     Glioma-Associated Oncogene Family Zinc Finger 11
GLI1 2 3 5     Glioma-Associated Oncogene 12
Glioma-Associated Oncogene Homolog 1 (Zinc Finger Protein)1 2     Zinc Finger Protein GLI12
Oncogene GLI2 3     Glioma-Associated Oncogene3

External Ids:    HGNC: 43171   Entrez Gene: 27352   Ensembl: ENSG000001110877   OMIM: 1652205   UniProtKB: P081513   

Export aliases for GLI1 gene to outside databases

Previous GC identifers: GC12P056141 GC12P054892


Summaries
for GLI1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for GLI1:
This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated
by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear
localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants
encoding different isoforms have been found for this gene. (provided by RefSeq, May 2009)

UniProtKB/Swiss-Prot: GLI1_HUMAN, P08151
Function: Acts as a transcriptional activator. May regulate the transcription of specific genes during normal
development. May play a role in craniofacial development and digital development, as well as development of the
central nervous system and gastrointestinal tract. Mediates SHH signaling and thus cell proliferation and
differentiation

summary for GLI1:
The hedgehog (Hh) signaling pathway is crucial in the development of all known animals. In the embryo, it
regulates morphogenesis of a variety of tissues and organs, in the adult, it controls stem cell
proliferation. There are three human Hh proteins; Sonic hedgehog (Shh), Desert hedgehog (Dhh) and Indian
hedgehog (Ihh). Each is expressed at different times of development and in specific cell types and they are
tightly controlled by highly complex, yet divergent transcriptional enhancers. Hh protein release and
diffusion is controlled by various proteins including Skinny hedgehog (Sit), Dispatched (Disp), Tout-velu
(Ttv) and Hedgehog-interacting protein (Hip). Hh proteins bind to the twelve transmembrane domain protein,
Patched (Ptc). In the absence of Hh proteins, Ptc catalytically inhibits Smo. Hh-Ptc binding results in loss
of Ptc activity and activation of Smo, which transduces the Hh signal to the cytoplasm. This leads to the
activation of the Ci/GLI family of transcription factors, through complex interactions of Costal2 (Cos2),
Fused (Fu) and Suppressor of fu [Su(fu)]. Furthermore, PKA, CK1, GSK-3 and Slimb modulate this signal
transduction pathway. Abberant activation of the Hh pathway has been linked to multiple types of human
cancer, particularly basal cell carcinoma. Disruption of Hh signaling during embryonic development, either
through congenital mutation or maternal teratogen consumption, can lead to severe developmental disorders
such as holoprosencephaly.

Gene Wiki entry for GLI1


Genomic Views
for GLI1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GLI1 gene promoter:
         NF-1   Sp1   p53   c-Myb   Nkx2-5   STAT5A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GLI1 promoter sequence
   Search SABiosciences Chromatin IP Primers for GLI1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GLI1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.2-q13.3   Ensembl cytogenetic band:  12q13.3   HGNC cytogenetic band: 12q13.2-q13.3

GLI1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GLI1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P057853:  view genomic region     (about GC identifiers)

Start:
 57,853,918 bp from pter      End:
 57,866,051 bp from pter
Size:
 12,134 bases      Orientation:
 plus strand

Proteins
for GLI1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: GLI1_HUMAN, P08151 (See protein sequence)
Recommended Name: Zinc finger protein GLI1  
Size: 1106 amino acids; 117904 Da
Subunit: Interacts with KIF7 (By similarity). Interacts with ZIC1; the interaction enhances transcription activation
Subcellular location: Cytoplasm. Nucleus. Note=Tethered in the cytoplasm by binding to SUFU. Activation and
translocation to the nucleus is promoted by interaction with STK36. Phosphorylation by ULK3 may promote nuclear
localization. Translocation to the nucleus is promoted by interaction with ZIC1
1 PDB 3D structure from and Proteopedia for GLI1:
2GLI (3D)    
Secondary accessions: D0EUY3 E9PQQ9 Q8TDN9
Alternative splicing: 2 isoforms:  P08151-1   P08151-2   (Undetectable in normal cells but highly expressed in cancer cells)

Explore the universe of human proteins at neXtProt for GLI1: NX_P08151

Post-translational modifications:

  • Phosphorylated in vitro by ULK31
  • Acetylation at Lys-518 down-regulates transcriptional activity. Deacetylated by HDAC11
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P08151

    • GLI1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001153517.1  NP_001161081.1  NP_005260.1  

    ENSEMBL proteins: 
     ENSP00000436671   ENSP00000228682   ENSP00000434421   ENSP00000434408   ENSP00000441006  
     ENSP00000437607  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: GLI1
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    Novus Biologicals GLI1 Protein
    Novus Biologicals GLI1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for GLI1

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA19878745
    GO:0005737cytoplasm IDA16229683
    GO:0005829cytosol IDA18559511
    GO:0005929cilium IEA--


    GLI1 for ontologies           About GeneDecksing



    GLI1 Antibody Products: 
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    Assay Products for GLI1: 
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    Uscn ELISAs and CLIAs for GLI1

    Protein Domains /
    Families
    for GLI1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    GLI1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry P08151

    ProtoNet protein and cluster: P08151

    1 Blocks protein family: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: GLI1_HUMAN, P08151
    Similarity: Belongs to the GLI C2H2-type zinc-finger protein family
    Similarity: Contains 5 C2H2-type zinc fingers


    Function
    for GLI1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: GLI1_HUMAN, P08151
    Function: Acts as a transcriptional activator. May regulate the transcription of specific genes during normal
    development. May play a role in craniofacial development and digital development, as well as development of the
    central nervous system and gastrointestinal tract. Mediates SHH signaling and thus cell proliferation and
    differentiation
    Induction: Amplified in glioblastoma cells

    miRNA
    Products:            		miRTarBase miRNAs that target GLI1:
    hsa-mir-125b (MIRT000350), hsa-mir-324-5p (MIRT000530), hsa-mir-326 (MIRT000082)

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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GLI1
    1 QIAGEN miScript miRNA Assays for microRNA that regulate GLI1:
    hsa-miR-616
    SwitchGear 3'UTR luciferase reporter plasmid: GLI1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
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    OriGene shRNA RFP: GLI1
    OriGene siRNA: GLI1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GLI1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for GLI1

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GLI1 (see all 4)
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    GenScript: all cDNA clones in your preferred vector (see all 3): GLI1 (NM_001167609)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GLI1 

    Cell Line
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    Search LifeMap BioReagents cell lines for GLI1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GLI1

    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA9118802
    GO:0003682chromatin binding IEA--
    GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI--
    GO:0008017microtubule binding IEA--


    GLI1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for GLI1:
     Upregulation of Wnt/beta-caten 

    Animal Models:
         Mouse knock-out Gli1tm1Alj for GLI1
         15 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Gli1):
     behavior/neurological  cellular  digestive/alimentary  embryogenesis  endocrine/exocrine gland 
     growth/size  limbs/digits/tail  mortality/aging  nervous system  no phenotypic analysis 
     normal  renal/urinary system  reproductive system  respiratory system  tumorigenesis 

    GLI1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for GLI1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Development_Hedgehog and PTH signaling pathways in bone and cartilage development
    		Development_Hedgehog and PTH signaling pathways in bone and cartilage development1.00
    		Development Hedgehog and PTH signaling pathways in bone and cartilage development0.97
    2Hedgehog Signaling Pathway
    		Hedgehog Signaling Pathway1.00
    		Hedgehog Pathway0.32
    3Basal cell carcinoma
    		Basal cell carcinoma1.00
    		Hedgehog signaling pathway0.41
    4Wnt / Hedgehog / Notch
    		Wnt / Hedgehog / Notch1.00
    5Hedgehog signaling events mediated by Gli proteins
    		Hedgehog signaling events mediated by Gli proteins1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for GLI1
        Development Hedgehog and PTH signaling pathways in bone and cartilage development


    1 Cell Signaling Technology (CST) Pathway for GLI1
        Wnt / Hedgehog / Notch

    1 Tocris Bioscience Pathway for GLI1
        Hedgehog Pathway

    1 GeneGo (Thomson Reuters) Pathway for GLI1
        Development Hedgehog and PTH signaling pathways in bone and cartilage development

    2 BioSystems Pathways for GLI1 
        Hedgehog Signaling Pathway
    Hedgehog signaling events mediated by Gli proteins


    3         Kegg Pathways  (Kegg details for GLI1):
        Hedgehog signaling pathway
    Pathways in cancer
    Basal cell carcinoma


    GLI1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GLI1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/56 Interacting proteins for GLI1 (P081511, 2, 3 ENSP000002286824) via UniProtKB, MINT, STRING, and/or I2D (see all 56)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITCHQ96J021, 3, ENSP000003639984EBI-308084,EBI-1564678 I2D: score=1 STRING: ENSP00000363998
    YWHAEP622582, 3, ENSP000002643354MINT-8009509 I2D: score=1 STRING: ENSP00000264335
    SUFUQ9UMX11, 3, ENSP000003589184EBI-308084,EBI-740595 I2D: score=3 STRING: ENSP00000358918
    DYRK1AQ136273, ENSP000003819324I2D: score=2 STRING: ENSP00000381932
    SAP18O004223, ENSP000003719734I2D: score=1 STRING: ENSP00000371973
    About this table

    Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001649osteoblast differentiation IDA12165851
    GO:0007224smoothened signaling pathway TAS11001584
    GO:0007283spermatogenesis IEA--
    GO:0007418ventral midline development IEA--
    GO:0008284positive regulation of cell proliferation IMP12165851


    GLI1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for GLI1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GLI1 for compounds           About GeneDecksing

    EMD Millipore small molecules for GLI1:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for GLI1

    Compounds for GLI1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    JK 184Downstream Hh signaling pathway inhibitor; inhibits alcohol dehydrogenase 7[315703-52-7]
    6 Novoseek chemical compound relationships for GLI1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cyclopamine 94.4 22 19203449 (2), 16616798 (2), 17200206 (2), 19120265 (1) (see all 16)
    zinc 55.6 29 8364225 (3), 2118997 (1), 9122207 (1), 18298960 (1) (see all 22)
    actb 50.9 2 15111311 (1), 15555571 (1)
    glucose 1.46 1 16341386 (1)
    phosphatidylinositol 0 1 16880536 (1)
    pd 98,059 0 2 16424016 (1), 17353198 (1)

    Search CenterWatch for drugs/clinical trials and news about GLI1 

    Transcripts
    for GLI1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for GLI1 gene (3 alternative transcripts): 
    NM_001160045.1  NM_001167609.1  NM_005269.2  

    Unigene Cluster for GLI1:

    GLI family zinc finger 1
    Hs.632702  [show with all ESTs]
    Unigene Representative Sequence: NM_005269
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000532291 ENST00000228682(uc009zpp.2 uc001snx.3 uc021qzi.1)
    ENST00000528432 ENST00000530789(uc009zpr.1) ENST00000528467 ENST00000527742
    ENST00000546141 ENST00000543426(uc009zpq.3)

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate GLI1:
    hsa-miR-616
    SwitchGear 3'UTR luciferase reporter plasmid: GLI1 3' UTR sequence
    Inhib. RNA
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): GLI1 (NM_001167609)
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GLI1

    Additional cDNA sequence: 

    AB239135.1 AB239328.1 AK297899.1 BC013000.2 GQ890670.2 X07384.1 

    5 DOTS entries:

    DT.40106320  DT.101958419  DT.121187597  DT.75125683  DT.100778191 

    24/45 AceView cDNA sequences (see all 45):

    AI373071 X07384 BE297073 NM_005269 BQ642167 BC013000 BM904427 BF204913 
    BG826489 BM921197 BG338339 BX100365 BG828954 BM719407 BE269753 AI971494 
    BM684238 BI114749 BM559945 BE298258 BG413394 BF204861 BX106497 BG826811 

    GeneLoc Exon Structure


    Expression
    for GLI1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GLI1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGTGTCTTAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    GLI1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/40 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 40) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Neural TubeDiencephalic Floor PlateEarly Caudal Floor Plate CellsNeural Ectoderm
    Neural TubeDiencephalic Ventricular ZoneMeso-diencephalic Dopaminergic Precursor CellsDopaminergic neurons
    Neural TubeMesencephalic Floor PlateEarly Floor Plate CellsNeural Ectoderm
    Neural TubeMesencephalic Ventricular ZoneMeso-diencephalic Dopaminergic Precursor CellsDopaminergic neurons
    AdiposeVascular AdiposeStromal Vascular Preadipocyte Progenitor CellsAdipose
    BoneAutopod PeriosteumImmature Endochondral OsteoblastsBone
    BoneCervical VertebraeImmature Endochondral OsteoblastsBone
    BoneLumbar VertebraeImmature Endochondral OsteoblastsBone
    BoneSacral VertebraeImmature Endochondral OsteoblastsBone
    BoneStylopod PeriosteumImmature Endochondral OsteoblastsBone
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Beating cell clusters (Spontaneous differen...)

    See GLI1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GLI1

    SOURCE GeneReport for Unigene cluster: Hs.632702

    UniProtKB/Swiss-Prot: GLI1_HUMAN, P08151
    Tissue specificity: Testis, myometrium and fallopian tube. Also expressed in the brain with highest expression in the
    cerebellum, optic nerve and olfactory tract

        SABiosciences Expression via Pathway-Focused PCR Arrays including GLI1 (see all 7): 
              Osteogenesis in human mouse rat
              Hedgehog Signaling Pathway in human mouse rat
              Primary Cilia in human mouse rat
              Breast Cancer in human mouse rat
              Stem Cell Signaling in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GLI1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GLI1

    Orthologs
    for GLI1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for GLI1 gene from 7/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves GLI11 GLI family zinc finger 1 59.23(n)
    53.39(a)    		   396045  XM_413682.2  XP_413682.2 
    lizard
    (Anolis carolinensis)    		 Reptilia GLI16
    		 --
    		 35(a)
    		 1 ↔ 1
    		 GL343212.1(667292-685220)
    zebrafish
    (Danio rerio)    		 Actinopterygii AY173030.12   -- 76.78(n)   352930  AY173030.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta ci6
    		 cubitus interruptus
    		 17(a)
    		 1 → many
    		 4(68336-77667)
    worm
    (Caenorhabditis elegans)    		 Secernentea ztf-146
    tra-16
    		 Sex-determining transformer protein 1
    		 18(a)
    11(a)
    		 possible ortholog
    possible ortholog
    		 X(14496015-14499364)
    III(11171993-11195108)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT4G066346
    		 uncharacterized zinc finger protein
    		 14(a)
    		 1 → many
    		 4(3764289-3766578)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    		 ZOS5-01 - C2H2 zinc finger protein, expressed
    		 16(a)
    13(a)
    		 many ↔ many
    many ↔ many
    		 2(20795085-20798606)
    5(321102-324421)


    ENSEMBL Gene Tree for GLI1 (if available)
    TreeFam Gene Tree for GLI1 (if available) 

    Paralogs
    for GLI1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GLI1 gene
    ZNF762  ZIC22  YY12  ZIC12  GLIS22  GLI22  ZNF1432  GLI32  
    YY22  MTF12  ZIC32  ZNF4102  ZFP422  GLIS12  ZIC42  GLIS32  
    ZIC52  
    18/37 SIMAP similar genes for GLI1 using alignment to 5 protein entries:     GLI1_HUMAN (see all proteins) (see all similar genes):
    DKFZp686N0199    KLF7    ZIC4    DKFZp686O1631    HZF16    ZNF
    ZNF78L1    GLIS3    KLF1    ZFS-5    ZSCAN21    smap-7
    GTF3A    ZNF808    kr-znf3    DKFZp434J0650    DKFZp666C237    GLI2

    GLI1 for paralogs           About GeneDecksing



    Genomic Variants
    for GLI1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/269 NCBI SNPs in GLI1 are shown (see all 269)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs617395691,2
    		F--54903428(+) CCAGCT/CGTGGT 3 -- ds50011Minor allele frequency- C:0.19NS 64
    rs733440741,2
    		C,F,--54904074(+) GAGACC/AGTCAT 3 -- ut312Minor allele frequency- A:0.50WA CSA 4
    rs557094051,2
    		--57851994(+) AGCGAG/TTCTCC 4 -- int1 us2k10--------
    rs1508878881,2
    		--57852037(+) GCCTGC/TGCCAC 4 -- us2k1 int10--------
    rs114633151,2
    		C,--57852084(+) GGTTT-/ACACCA 4 -- us2k1 int11Minor allele frequency- A:0.50NA 2
    rs1392967031,2
    		--57852169(+) CAGGTC/GTGAGC 4 -- us2k1 int10--------
    rs1842346691,2
    		--57852233(+) AGACTC/GACTGG 4 -- us2k1 int10--------
    rs1443472351,2
    		--57852314(+) CCCAGC/GTACTT 3 -- us2k10--------
    rs1465448061,2
    		--57852483(+) GGGCTC/TGAGGC 3 -- us2k10--------
    rs128217361,2
    		C--57852566(+) ACCCTC/TTGGGG 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for GLI1 (57853918 - 57866051 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for GLI1
         2 CNVs: 30602 3891
    Human Gene Mutation Database (HGMD): GLI1

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for GLI1

    Disorders / Diseases
    for GLI1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    GLI1 for disorders           About GeneDecksing

    OMIM gene information: 165220    OMIM disorders: --

    20/78 diseases for GLI1 (see all 78):    About MalaCards
    basal cell carcinoma    pallister-hall syndrome    holoprosencephaly    splenic marginal zone lymphoma
    necrobiosis lipoidica    carcinoma    diffuse large b-cell lymphoma    human t-cell leukemia virus type 1
    anal canal carcinoma    nevoid basal cell carcinoma syndrome    ventricular septal defect    granuloma annulare
    plexiform neurofibroma    non-small cell lung carcinoma    b-cell lymphomas    developmental disabilities
    anaplastic large cell lymphoma    vacterl association    ring chromosomes    urinary bladder cancer

    6 diseases from the University of Copenhagen DISEASES database for GLI1:
    Basal cell carcinoma     Medulloblastoma     Nevoid basal cell carcinoma syndrome     Pancreatic cancer
    Polydactyly     Malignant glioma

    10/34 Novoseek disease relationships for GLI1 gene (see all 34)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma basal cell 78.4 30 10504446 (6), 19948058 (4), 18754037 (1), 12235001 (1) (see all 13)
    medulloblastoma 73.3 31 15806168 (5), 18924150 (4), 17200206 (3), 20081843 (1) (see all 8)
    pallister-hall syndrome 66.8 1 12017244 (1)
    rhabdomyosarcoma 51.2 7 15024701 (1), 20152358 (1), 8221695 (1), 19454362 (1) (see all 5)
    tumors 50.6 81 17565866 (4), 18381430 (3), 19088834 (3), 16421275 (2) (see all 42)
    cancer 48.7 27 10630638 (3), 16855373 (2), 17638910 (1), 19930158 (1) (see all 20)
    pancreatic cancer 45.1 11 19736394 (5), 18410405 (4), 17332349 (1)
    odontogenic tumors 43.8 8 16376138 (3), 15128061 (2), 19082818 (1)
    glioblastoma 43.1 6 7654443 (1), 8586464 (1), 19706761 (1), 1825351 (1) (see all 6)
    gastric cancer 40.8 6 15905200 (2), 19930158 (1), 16258256 (1), 17035233 (1) (see all 5)

    Human Genome Epidemiology (HuGE) Navigator: GLI1 (5 documents)

    Export disorders for GLI1 gene to outside databases

    Publications
    for GLI1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GLI1 gene, integrated from 9 sources (see all 339):
    (articles sorted by number of sources associating them with GLI1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel splice variant of GLI1 that promotes glioblastoma cell migration and invasion. (PubMed id 19706761)1, 2, 9 Lo H.W.... Ali-Osman F. (2009)
    2. Physical and functional interactions between Zic and Gli proteins. (PubMed id 11238441)1, 2, 9 Koyabu Y....Mikoshiba K. (2001)
    3. Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation. (PubMed id 20081843)1, 2, 9 Canettieri G....Gulino A. (2010)
    4. Identification of a novel serine/threonine kinase ULK 3 as a positive regulator of Hedgehog pathway. (PubMed id 19878745)1, 2 Maloverjan A....Osterlund T. (2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Gli regulation by the opposing activities of fused and suppressor of fused. (PubMed id 10806483)1, 2 Murone M.... de Sauvage F.J. (2000)
    7. Identification of polymorphic variants of the GLI1 oncogene. (PubMed id 10951255)1, 2 Wang X.Q.... Rothnagel J.A. (2000)
    8. Crystal structure of a five-finger GLI-DNA complex: new perspectives on zinc fingers. (PubMed id 8378770)1, 2 Pavletich N.P. and Pabo C.O. (1993)
    9. The GLI gene is a member of the Kruppel family of zinc finger proteins. (PubMed id 2832761)1, 2 Kinzler K.W.... Vogelstein B. (1988)
    10. The GLI-Kruppel family of human genes. (PubMed id 2850480)1, 3 Ruppert J.M.... Vogelstein B. (1988)

    External Searches for GLI1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing GLI1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2735 HGNC: 4317 AceView: GLI Ensembl:ENSG00000111087 euGenes: HUgn2735
    ECgene: GLI1 Kegg: 2735 H-InvDB: GLI1

    Other Databases showing GLI1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing GLI1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GLI1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GLI1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for GLI1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for GLI1 gene:
    Search GeneIP for patents involving GLI1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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