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GLI1 Gene

protein-coding GIFtS: 65

GC12P056141

GLI family zinc finger 1
(Previous names: glioma-associated oncogene homolog 1 (zinc finger protein), glioma-associated oncogene family zinc finger 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: GLI)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
GLI ^², ³

Descriptions
GLI family zinc finger 1 ^²
Glioma-associated oncogene ^³
Oncogene GLI ^³
glioma-associated oncogene family zinc finger 1 ^¹, ²
glioma-associated oncogene homolog 1 (zinc finger protein) ^¹, ²

External Ids
HGNC: 4317¹
Entrez Gene: 2735²
UniProtKB: P08151³
Ensembl: ENSG00000111087⁷

Search outside databases for aliases for GLI1 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for GLI1:

This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription

factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell

proliferation. The activity and nuclear localization of this protein is negatively regulated by

p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been

found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: GLI1_HUMAN, P08151

Function: May regulate the transcription of specific genes during normal development. May play a

role in craniofacial development and digital development, as well as development of the central

nervous system and gastrointestinal tract. Mediates SHH signaling and thus cell proliferation and

differentiation

Gene Wiki entry for GLI1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the GLI1 gene

Entrez Gene cytogenetic band: 12q13.2-q13.3 Ensembl cytogenetic band: 12q13.3 HGNC cytogenetic band: 12q13.2-q13.3

GLI1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P056141: (about GC identifiers)

Start:	56,140,201 bp from pter
End:	56,152,312 bp from pter
Size:	12,112 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000012.10 NT_029419.11

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: GLI1_HUMAN, P08151 (See protein sequence)

Recommended Name: Zinc finger protein GLI1

Size: 1106 amino acids; 117904 Da

Subcellular location: Cytoplasm. Nucleus. Note=Tethered in the cytoplasm by binding to SUFU.

Activation and translocation to the nucleus is promoted by interaction with STK36

PDB structures from and Proteopedia :

2GLI (3D)

Secondary accessions: Q8TDN9

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001153517.1 NP_005260.1

ENSEMBL proteins:

ENSP00000228682

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Gli1)
	Human Recombinant Proteins from Abnova (GLI1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IDA	10504446

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Antibodies for GLI1:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of GLI1
	Sigma-Aldrich Antibodies for GLI1
	R&D Systems Antibodies for GLI1 (GLI-1)
	Cell Signaling Technology (CST) Antibodies for GLI1
	Antibodies from Abcam (Gli1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (GLI1)
	Novus Biologicals Antibodies for GLI1

Assays for GLI1:

	Invitrogen Assays for GLI1
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P08151

ProtoNet protein and cluster: P08151

1 Blocks protein family: IPB007086 C2H2-type zinc finger signature

UniProtKB/Swiss-Prot: GLI1_HUMAN, P08151

Similarity: Belongs to the GLI C2H2-type zinc-finger protein family

Similarity: Contains 5 C2H2-type zinc fingers

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GLI1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GLI1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005269

Applied Biosystems Silencer® siRNAs for GLI1

Sigma-Aldrich siRNA for GLI1

Sigma-Aldrich shRNA for GLI1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_005269
Myc/DDK tagged cDNA clone in CMV expression vector: NM_005269
untagged cDNA clone in CMV expression vector: NM_005269

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005269

UniProtKB/Swiss-Prot: GLI1_HUMAN, P08151

Function: May regulate the transcription of specific genes during normal development. May play a

role in craniofacial development and digital development, as well as development of the central

nervous system and gastrointestinal tract. Mediates SHH signaling and thus cell proliferation and

differentiation

Induction: Amplified in glioblastoma cells

15 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Gli1):

behavior/neurological	cellular	digestive/alimentary	embryogenesis	endocrine/exocrine gland
growth/size	lethality-prenatal/perinatal	life span-post-weaning/aging	limbs/digits/tail	nervous system
no phenotypic analysis	normal	reproductive system	respiratory system	tumorigenesis

5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IDA	9118802
GO:0003682	chromatin binding	IEA	--
GO:0005515	protein binding	IPI	10564661 10806483 11238441
GO:0008017	microtubule binding	IEA	--
GO:0008270	zinc ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5 Sigma-Aldrich "Your Favorite Gene" Pathways for GLI1 (Your Favorite Gene powered by Ingenuity)

Sonic Hedgehog Signaling
Axonal Guidance Signaling
Molecular Mechanisms of Cancer
Basal Cell Carcinoma Signaling
Corticotropin Releasing Hormone Signaling

GeneDecks GLI1 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for GLI1

5/78 Interacting proteins for GLI1 (ENSP00000228682³ P08151^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 78 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
STK36	Q9NRP7¹	STRING (score=.984) EBI-308084, EBI-863797
Zic1 Zic1 (xeno)	P46684¹^,²	EBI-308084, EBI-308006 MINT-16699 MINT-16700
Zic2 Zic2 (xeno)	Q62520¹^,²	EBI-308084, EBI-308076 MINT-13827
SUFU	ENSP00000358918³	STRING (score=.999)
PTCH1	ENSP00000332353³	STRING (score=.996)

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5/18 Gene Ontology (GO) biological process terms (links to tree view) (see all 18 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001649	osteoblast differentiation	IDA	12165851
GO:0006350	transcription	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0007275	multicellular organismal development	IEA	--
GO:0007283	spermatogenesis	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for GLI1

Browse Small Molecules at Sigma-Aldrich

Compounds for GLI1 available from Tocris Bioscience

Compound	Action	CAS number
JK 184	Downstream Hh signaling pathway inhibitor; inhibits alcohol dehydrogenase 7	[315703-52-7]

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6 Novoseek chemical compound relationships for GLI1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
cyclopamine	93.48	18	19203449 (2), 16616798 (2), 17200206 (2), 19120265 (1) (see all 12)
zinc	57.04	29	8364225 (3), 2118997 (1), 9122207 (1), 18298960 (1) (see all 22)
actb	56.62	2	15111311 (1), 15555571 (1)
phosphatidylinositol	3.74	1	16880536 (1)
glucose	1.80	1	16341386 (1)
pd 98,059	0.71	2	16424016 (1), 17353198 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GLI1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GLI1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005269

Sigma-Aldrich siRNA for GLI1

Sigma-Aldrich shRNA for GLI1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005269

REFSEQ mRNAs for GLI1 gene (2 alternative transcripts):

NM_001160045.1 NM_005269.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_005269

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005269
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_005269
                                 untagged cDNA clone in CMV expression vector: NM_005269

Additional cDNA sequence:

AB239135.1 AB239328.1 AK297899.1 BC013000.2 X07384.1

5 DOTS entries:

DT.40106320 DT.101958419 DT.121187597 DT.75125683 DT.100778191

24/45 AceView cDNA sequences (see all 45 ):

NM_005269 BQ642167 AI373071 X07384 BE297073 BC013000 CA432143 BE298258

BX100365 BG826489 BG826811 BM719407 AI971494 BM904427 BE269753 BM684238

BE206297 BI113880 BM921197 BI114749 BF309357 BM559945 BG413394 BG338339

highest scoring ESTs for GLI1:

X07384 AI473373 AI971494 AL121200 AU143814 AW103457 BC013000 BE019534 BE206073 BE206297

Unigene Cluster for GLI1:

GLI family zinc finger 1

Hs.632702 [show with all ESTs]

Unigene Representative Sequence: NM_005269

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000228682

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

GLI1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for GLI1

¹ / ² / ³

3 probe-sets matching GLI1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
33474_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	X07384	1.00	1.00	1.00	1
206646_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_005269	0.60	1.00	0.82	1
206646_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AGTGTCTTAC

SOURCE GeneReport for Unigene cluster: Hs.632702
Expression variation in blood from EXPOLDB for GLI1
UniProtKB/Swiss-Prot: GLI1_HUMAN, P08151
Tissue specificity: Testis, myometrium and fallopian tube

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for GLI1 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	GLI1¹	--	glioma-associated oncogene homolog 1 (zinc finger protein)	89.76(n) 91.3(a)	481126 XM_853792.1 XP_858885.1
cow (Bos taurus)	GLI1¹	--	glioma-associated oncogene homolog 1 (zinc finger protein)	88.87(n) 90.05(a)	517588 XM_595760.3 XP_595760.2
rat (Rattus norvegicus)	Gli1¹	--	GLI-Kruppel family member GLI1	83.85(n) 86.23(a)	140589 XM_345832.3 XP_345833.2
mouse (Mus musculus)	Gli1^{1, 5}	10 (69.00 cM)⁵	GLI-Kruppel family member GLI1^{1, 5}	84.03(n)¹ 86.05(a)¹	14632¹ NM_010296.2¹ NP_034426.2¹ AB025922⁵ AF026305⁵ (see all 13)
chicken (Gallus gallus)	GLI1¹	--	glioma-associated oncogene homolog 1 (zinc finger protein)	67.68(n) 65.4(a)	396045 XM_413682.1 XP_413682.1

About this table Species with no ortholog for GLI1

ENSEMBL Gene Tree for GLI1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for GLI1 gene

YY2² ZFP42² YY1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/63 NCBI SNPs in GLI1 are shown (see all 63 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 61)

AB	SNP ID	Valid	Chr 12 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2242578^1,2	A,C,F,H	56139420(+)	`CTAGGC/GAAAGG`	1	--	ng5¹ trp³		14	EA NA EU WA	2636
	rs2228224^1,2	A,C,F,H	56151588(+)	`GGGGGA/GTTCCC`	1	G/D	mis¹ ese³		10	MN EA NA EU WA	2190
	rs12578516^1,2	H	56149655(+)	`CCACTC/ATTCGC`	1	I/L	mis¹ ese³		4	EU EA WA	420
--	rs11553626^1,2	H	56150891(+)	`ATGCTA/GGAGGG`	1	R/G	mis¹ ese³		4	EU EA WA	406
	rs2228225^1,2	C,F,H,O	56145698(+)	`CGGGAG/AGAACC`	1	E/E	syn¹		14	MN NA EU EA WA	1220
	rs7973381^1,2	A,C,F,H	56146313(+)	`ATCCAC/TGGGGA`	1	H/H	syn¹ ese³		7	EU EA WA NA	554
	rs4760148^1,2	A,C,F,H	56143043(+)	`GGTTAC/GAGCAA`	1	--	int¹		7	NA EU EA WA	554
--	rs4760259^1,2	A,C,F,H	56147093(+)	`CAAGAC/TGACCC`	1	--	int¹		8	EU EA WA	786
	rs2292657^1,2	A,C,F,H	56146199(-)	`TTCCAC/TGACTC`	1	--	int¹		11	EA EU WA	2492
	rs3817474^1,2	A,C,F,H	56145102(-)	`TTGGGC/TTATTT`	1	--	int¹		11	EA NA EU WA	692

About this table

HapMap Linkage Disequilibrium images for GLI1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 165220

UniProtKB/Swiss-Prot: GLI1_HUMAN, P08151

Defects in GLI1 may be a cause of breast cancer

10/34 Novoseek disease relationships for GLI1 gene (see all 34 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
carcinoma basal cell	77.03	24	10504446 (6), 18754037 (1), 12235001 (1), 12907651 (1) (see all 12)
medulloblastoma	69.48	30	15806168 (5), 18924150 (4), 17200206 (3), 17522332 (1) (see all 7)
pallister-hall syndrome	69.20	1	12017244 (1)
odontogenic tumors	47.50	8	16376138 (3), 15128061 (2), 19082818 (1)
rhabdomyosarcoma	45.72	5	15024701 (1), 8221695 (1), 11948912 (1)
tumors	45.31	69	17565866 (4), 18381430 (3), 19088834 (3), 16421275 (2) (see all 36)
glioblastoma	44.25	5	7654443 (1), 8586464 (1), 1825351 (1), 12241103 (1) (see all 5)
cancer	42.03	17	10630638 (3), 16855373 (2), 17638910 (1), 17054904 (1) (see all 13)
skin tumor	38.54	3	11378387 (1), 16158046 (1)
adenocarcinoma tubular	34.40	3	16810741 (1), 17259107 (1)

About this table

Human Genome Epidemiology Navigator: GLI1 (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/237 PubMed articles for GLI1 gene (see all 237 ):

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Gli regulation by the opposing activities of fused and suppressor of fused. (PubMed id 10806483)^{3, 4} Murone M.... de Sauvage F.J. (2000)
Identification of polymorphic variants of the GLI1 oncogene. (PubMed id 10951255)^{3, 4} Wang X.Q.... Rothnagel J.A. (2000)
Crystal structure of a five-finger GLI-DNA complex: new perspectives on zinc fingers. (PubMed id 8378770)^{3, 4} Pavletich N.P. and Pabo C.O. (1993)
The GLI gene is a member of the Kruppel family of zinc finger proteins. (PubMed id 2832761)^{3, 4} Kinzler K.W.... Vogelstein B. (1988)
The GLI-Kruppel family of human genes. (PubMed id 2850480)^{2, 3} Ruppert J.M.... Vogelstein B. (1988)
Analysis of germline GLI1 variation implicates hedgehog signalling in the regulation of intestinal inflammatory pathways. (PubMed id 19071955)^{1, 3} Lees C.W....Satsangi J. (2008)
Loss of protein kinase Calpha expression may enhance the tumorigenic potential of Gli1 in basal cell carcinoma. (PubMed id 12907651)^{1, 3} Neill G.W....Quinn A.G. (2003)
Gli1 protein is expressed in basal cell carcinomas, outer root sheath keratinocytes and a subpopulation of mesenchymal cells in normal human skin. (PubMed id 10504446)^{1, 3} Ghali L....Quinn A.G. (1999)
Defining a role for Sonic hedgehog pathway activation in desmoplastic medulloblastoma by identifying GLI1 target genes. (PubMed id 18924150)^{1, 3} Yoon J.W....Walterhouse D. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 2735	HGNC: 4317	AceView: GLI	Ensembl:ENSG00000111087	euGenes: HUgn2735
ECgene: GLI1	H-InvDB: GLI1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for GLI1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for GLI1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for GLI1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for GLI1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for GLI1		Antibodies for GLI1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for GLI1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (GLI1)
	Antibodies (GLI1)
	Chimera RNAi (GLI1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for GLI1

	Recombinant Proteins (Gli1)
	Antibodies (Gli1)

Search OriGene for GLI1

Tocris compounds for GLI1

	Drugs for GLI1
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for GLI1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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GLI1 Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for GLI1

Summaries
for GLI1

Genomic Location
for GLI1

Proteins
for GLI1

Protein Domains/
Families
for GLI1

Gene Function
for GLI1

Pathways & Interactions
for GLI1

Drugs & Compounds
for GLI1

Transcripts
for GLI1

Expression
for GLI1

Orthologs
for GLI1

Paralogs
for GLI1

SNPs/Variants
for GLI1

Disorders & Mutations
for GLI1

Medical News
for GLI1

Publications
for GLI1

Search for GLI1

Genome Databases showing GLI1

Other Databases showing GLI1

Specialized Databases showing GLI1

Licensable Technologies
for GLI1

Services
for GLI1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

GLI1 Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor GLI1

Summariesfor GLI1

Genomic Locationfor GLI1

Proteinsfor GLI1

Protein Domains/Familiesfor GLI1

Gene Functionfor GLI1

Pathways & Interactionsfor GLI1

Drugs & Compoundsfor GLI1

Transcriptsfor GLI1

Expression for GLI1

Orthologsfor GLI1

Paralogsfor GLI1

SNPs/Variantsfor GLI1

Disorders & Mutationsfor GLI1

Medical Newsfor GLI1

Publicationsfor GLI1

Search for GLI1

Genome Databases showing GLI1

Other Databases showing GLI1

Specialized Databases showing GLI1

Licensable Technologiesfor GLI1

Servicesfor GLI1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for GLI1

Summaries
for GLI1

Genomic Location
for GLI1

Proteins
for GLI1

Protein Domains/
Families
for GLI1

Gene Function
for GLI1

Pathways & Interactions
for GLI1

Drugs & Compounds
for GLI1

Transcripts
for GLI1

Expression
for GLI1

Orthologs
for GLI1

Paralogs
for GLI1

SNPs/Variants
for GLI1

Disorders & Mutations
for GLI1

Medical News
for GLI1

Publications
for GLI1

Licensable Technologies
for GLI1

Services
for GLI1