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GLG1 Gene

protein-coding   GIFtS: 59
GCID: GC16M074481

Golgi Glycoprotein 1

(Previous name: golgi apparatus protein 1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Golgi Glycoprotein 11 2     MG1602 3
Golgi Apparatus Protein 11 2     E-Selectin Ligand 12 3
Cysteine-Rich Fibroblast Growth Factor Receptor2 3     MG-1602
Golgi Sialoglycoprotein MG-1602 3     CFR13
CFR-12 3     ESL13
ESL-12 3     

External Ids:    HGNC: 43161   Entrez Gene: 27342   Ensembl: ENSG000000908637   OMIM: 6007535   UniProtKB: Q928963   

Export aliases for GLG1 gene to outside databases

Previous GC identifers: GC16U990026 GC16M075446 GC16M074225 GC16M074266 GC16M074265 GC16M073044 GC16M060230


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for GLG1 Gene:
GLG1 (golgi glycoprotein 1) is a protein-coding gene. Diseases associated with GLG1 include lateral sclerosis, and amyotrophic lateral sclerosis. GO annotations related to this gene include receptor binding.

UniProtKB/Swiss-Prot: GSLG1_HUMAN, Q92896
Function: Binds fibroblast growth factor and E-selectin (cell-adhesion lectin on endothelial cells mediating the
binding of neutrophils)

Gene Wiki entry for GLG1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NC_018927.2  NT_010498.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the GLG1 gene promoter:
         Tal-1   GATA-3   p300   c-Ets-1   E47   GATA-1   GATA-2   Sox9   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGLG1 promoter sequence
   Search Chromatin IP Primers for GLG1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GLG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.3   Ensembl cytogenetic band:  16q23.1   HGNC cytogenetic band: 16q22-q23

GLG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GLG1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M074481:  view genomic region     (about GC identifiers)

Start:
74,481,325 bp from pter      End:
74,641,042 bp from pter
Size:
159,718 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for GLG1

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GSLG1_HUMAN, Q92896 (See protein sequence)
Recommended Name: Golgi apparatus protein 1 precursor  
Size: 1179 amino acids; 134552 Da
Developmental stage: Expressed both in adult and fetal tissues
Sequence caution: Sequence=AAB02178.1; Type=Frameshift; Positions=27, 35;
Secondary accessions: B7Z8Y4 D3DUJ7 Q13221 Q6P9D1
Alternative splicing: 3 isoforms:  Q92896-1   Q92896-2   Q92896-3   (No experimental confirmation available. Contains a phosphoserine at position 1190)

Explore the universe of human proteins at neXtProt for GLG1: NX_Q92896

Explore proteomics data for GLG1 at MOPED

Post-translational modifications: 

  • Fucosylation is essential for binding to E-selectin (By similarity)1
  • N-glycosylated. Contains sialic acid residues (By similarity)1
  • Glycosylation2 at Asn165, Asn210, Asn581, Asn677, Thr739, Asn786
  • Modification sites at PhosphoSitePlus

  • See GLG1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001139138.1  NP_001139139.1  NP_036333.2  

    ENSEMBL proteins: 
     ENSP00000205061   ENSP00000405984   ENSP00000406946   ENSP00000455950   ENSP00000454218  
     ENSP00000455927   ENSP00000456195  
    Reactome Protein details: Q92896

    GLG1 Human Recombinant Protein Products:

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    GLG1 Antibody Products:

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    Cloud-Clone Corp. ELISAs for GLG1
    Cloud-Clone Corp. CLIAs for GLG1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR017873 Cys-rich_GLG1_repeat_euk
     IPR001893 Cys-rich_GLG1_repeat

    Graphical View of Domain Structure for InterPro Entry Q92896

    ProtoNet protein and cluster: Q92896

    UniProtKB/Swiss-Prot: GSLG1_HUMAN, Q92896
    Similarity: Contains 16 Cys-rich GLG1 repeats


    GLG1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GSLG1_HUMAN, Q92896
    Function: Binds fibroblast growth factor and E-selectin (cell-adhesion lectin on endothelial cells mediating the
    binding of neutrophils)

         Genatlas biochemistry entry for GLG1:
    membrane sialoglycoprotein of the Golgi apparatus,binding fibroblast growth factor and E selectin,ubiquitous

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding TAS7531823
         
    GLG1 for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Glg1):
     craniofacial  digestive/alimentary  growth/size/body  limbs/digits/tail  mortality/aging 
     skeleton 

    GLG1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Glg1tm1Brle for GLG1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GLG1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GLG1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GLG1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GLG1

    miRNA
    Products:
        
    miRTarBase miRNAs that target GLG1:
    hsa-mir-155-5p (MIRT021027), hsa-mir-21-5p (MIRT031040), hsa-mir-26a-5p (MIRT050160), hsa-mir-335-5p (MIRT019075)

    Block miRNA regulation of human, mouse, rat GLG1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GLG1 (see all 114):
    hsa-miR-26a-2* hsa-miR-607 hsa-miR-640 hsa-miR-4254 hsa-miR-4272 hsa-miR-218-1* hsa-miR-374a hsa-miR-3138
    SwitchGear 3'UTR luciferase reporter plasmidGLG1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for GLG1
    Predesigned siRNA for gene silencing in human, mouse, rat GLG1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 3): GLG1 (NM_001145667)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GLG1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GLG1

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GLG1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GSLG1_HUMAN, Q92896: Golgi apparatus membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    endoplasmic reticulum1
    extracellular1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005794Golgi apparatus IDA--
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    GLG1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GLG1 About   (see all 12)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    PPAR Pathway0.66
    Cellular Apoptosis Pathway0.85
    Rac1 Pathway0.65
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    2CREB Pathway
    CREB Pathway0.68
    Activation of PKC through GPCR0.63
    3p70S6K Signaling
    p70S6K Signaling0.60
    Renin-Angiotensin Pathway0.60
    4PAK Pathway
    PAK Pathway0.56
    Antioxidant Action of Vitamin-C0.56
    5Phospholipase-C Pathway
    PTEN Pathway0.56
    Phospholipase-C Pathway0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GLG1 (see all 23)
        MAPK Signaling
    Nuclear Receptor Activation by Vitamin-A
    DHA Signaling
    Actin-Based Motility by Rho Family GTPases
    Telomerase Components in Cell Signaling

    1 BioSystems Pathway for GLG1
        TNF-alpha/NF-kB Signaling Pathway

    1 Reactome Pathway for GLG1
        Cell surface interactions at the vascular wall


    1 Kegg Pathway  (Kegg details for GLG1):
        Cell adhesion molecules (CAMs)


    GLG1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GLG1
    Interactions:

        GeneGlobe Interaction Network for GLG1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for GLG1 (Q928962, 3 ENSP000002050614) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NFKB2Q006532, 3MINT-48718 MINT-47917 I2D: score=5 
    SELEP165813, ENSP000003317364I2D: score=2 STRING: ENSP00000331736
    CDC23Q9UJX23I2D: score=5 
    NAT9Q9BTE03I2D: score=5 
    INTS1Q8N2013I2D: score=4 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007596blood coagulation TAS--
    GO:0010955negative regulation of protein processing IEA--
    GO:0030512negative regulation of transforming growth factor beta receptor signaling pathway IEA--
    GO:0032330regulation of chondrocyte differentiation IEA--
    GO:0050900leukocyte migration TAS--

    GLG1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GLG1 (GSLG1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for GLG1 gene (3 alternative transcripts): 
    NM_001145666.1  NM_001145667.1  NM_012201.5  

    Unigene Cluster for GLG1:

    Golgi glycoprotein 1
    Hs.109731  [show with all ESTs]
    Unigene Representative Sequence: NR_027264
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000205061(uc002fcx.3 uc002fcw.4) ENST00000422840(uc002fcy.4 uc002fcz.4)
    ENST00000447066 ENST00000567951 ENST00000562090 ENST00000561942 ENST00000561481
    ENST00000563646 ENST00000563432 ENST00000566601 ENST00000567911 ENST00000565474
    ENST00000565260
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate GLG1 (see all 114):
    hsa-miR-26a-2* hsa-miR-607 hsa-miR-640 hsa-miR-4254 hsa-miR-4272 hsa-miR-218-1* hsa-miR-374a hsa-miR-3138
    SwitchGear 3'UTR luciferase reporter plasmidGLG1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 3): GLG1 (NM_001145667)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GLG1
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat GLG1
      QuantiFast Probe-based Assays in human, mouse, rat GLG1

    Additional mRNA sequence: 

    AK025457.1 AK026972.1 AK027032.1 AK057359.1 AK095842.1 AK096068.1 AK131501.1 AK172806.1 
    AK304156.1 BC031836.1 BC040133.1 BC060822.1 BX648396.1 NR_027264.1 NR_027265.1 U28811.1 
    U64791.1 

    Selected DOTS entries (see all 33):

    DT.101985672  DT.454490  DT.95124543  DT.91826725  DT.95143203  DT.95262500  DT.116079  DT.120698505 
    DT.95115232  DT.99932975  DT.40132431  DT.100793888  DT.120675441  DT.75117530  DT.95178262  DT.100030157 
    DT.91757268  DT.100793886  DT.86839248  DT.95115268  DT.99935725  DT.100030158  DT.91757269  DT.91757278 

    Selected AceView cDNA sequences (see all 391):

    AA454960 CA427879 BX956205 CF780867 AI271414 AA693640 AA948161 CR615957 
    AA297637 AW862576 AI653157 BM563506 CB162466 CB117653 CD643019 BF726969 
    BE881062 BQ006903 CD558976 BM786030 AA075200 BQ711176 BQ430206 AI613158 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GLG1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGTCCTCCT
    GLG1 Expression
    About this image

    GLG1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GLG1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.109731

    UniProtKB/Swiss-Prot: GSLG1_HUMAN, Q92896
    Tissue specificity: Widely expressed. Highest levels in pancreas, skeletal muscle, placenta, heart, testis and
    ovary. Also found in the kidney, liver, lung and brain

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    QuantiFast Probe-based Assays in human, mouse, rat GLG1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GLG1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for GLG1 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Glg11 , 5 golgi apparatus protein 11, 5 90.5(n)1
    98.79(a)1
      8 (57.98 cM)5
    203401  NM_009149.21  NP_033175.11 
     1111544215 
    chicken
    (Gallus gallus)
    Aves GLG11 golgi glycoprotein 1 81.87(n)
    94.21(a)
      396492  NM_205496.1  NP_990827.1 
    lizard
    (Anolis carolinensis)
    Reptilia GLG16
    golgi glycoprotein 1
    92(a)
    1 ↔ 1
    GL343891.1(91820-124423)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.73632 Xenopus laevis transcribed sequence with moderate similarity more 78.38(n)    48044368 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.120072 Transcribed sequence with moderate similarity to protein more 77.93(n)    CK146098.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Glg11 Golgi complex-localized glycoprotein 1 47.66(n)
    35.55(a)
      40382  NM_001275234.1  NP_001262163.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F14E5.23
    CELE_F14E5.21
    cysteine-rich fibroblast growth factor
    receptor3
    CELE_F14E5.21
    33(a)3
    46.75(n)1
    35.73(a)1
      II(8424217-8428760)3
    1743421  NM_001026917.51  NP_001022088.11 


    ENSEMBL Gene Tree for GLG1 (if available)
    TreeFam Gene Tree for GLG1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GLG1 (see all 3801)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1431056491,2
    C--74480876(+) ACTGAC/TGCAGG 5 -- int10--------
    rs755329681,2
    F--74480980(+) CCACAC/TGTCAG 5 -- int11Minor allele frequency- T:0.09WA 118
    rs759440061,2
    C,F--74481113(+) CGTGAC/TTTCCA 5 -- int11Minor allele frequency- T:0.03NA 120
    rs38634411,2
    C--74481130(-) ATGCTGCT/-AGTAG 5 -- int11Minor allele frequency- -:0.50NA 2
    rs1997127981,2
    C--74481132(-) ATGCTA/GCTAGT 5 -- int10--------
    rs2018069611,2
    --74481134(+) TAGCA-/GCATAC 5 -- int10--------
    rs169438851,2
    C,F,H--74481327(+) AGATTT/CAACAA 5 -- nc-transcript-variantut3114Minor allele frequency- C:0.02NA NS EA 1582
    rs1861769041,2
    --74481350(+) AAACTC/GTTTAT 5 -- nc-transcript-variantut310--------
    rs1403637501,2
    C--74481358(+) TATTAA/GATTCT 5 -- nc-transcript-variantut310--------
    rs1504080781,2
    C--74481581(+) TCACAC/TAGCAT 5 -- nc-transcript-variantut310--------

    HapMap Linkage Disequilibrium report for GLG1 (74481325 - 74641042 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for GLG1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2660806CNV Deletion23128226
    esv2676990CNV Deletion23128226
    nsv509632CNV Insertion20534489
    nsv833278CNV Loss17160897
    nsv833277CNV Loss17160897
    nsv833279CNV Loss17160897
    esv32537CNV Gain17666407
    nsv906905CNV Gain21882294
    dgv901e1CNV Complex17122850
    dgv900e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600753    OMIM disorders: --

    8 diseases for GLG1:    
    About MalaCards
    lateral sclerosis    amyotrophic lateral sclerosis    astrocytoma    endotheliitis
    hepatitis    breast cancer    prostatitis    malaria


    GLG1 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for GLG1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    amyotrophic lateral sclerosis 36.1 1 10727699 (1)
    tumors 3.1 9 15994950 (3), 12684670 (1), 9398215 (1)

    Genetic Association Database (GAD): GLG1
    Human Genome Epidemiology (HuGE) Navigator: GLG1 (2 documents)

    Export disorders for GLG1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GLG1 gene, integrated from 10 sources (see all 48):
    (articles sorted by number of sources associating them with GLG1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and sequence analysis of the human MG160, a fibroblast growth factor and E-selectin binding membrane sialoglycoprotein of the Golgi apparatus. (PubMed id 8985126)1, 2, 9 Mourelatos Z.... Gonatas N.K. (DNA Cell Biol. 1996)
    2. Latent transforming growth factor-beta complex in Chinese hamster ovary cells contains the multifunctional cysteine-rich fibroblast growth factor receptor, also termed E-selectin-ligand or MG-160. (PubMed id 9182700)1, 2, 9 Olofsson A.... Heldin C.-H. (Biochem. J. 1997)
    3. Assignment of the GLG1 gene for MGF-160, a fibroblast growth factor and E-selectin binding membrane sialoglycoprotein of the Golgi apparatus, to chromosome 16q22-q23 by fluorescence in situ hybridization. (PubMed id 8530051)1, 3, 9 Mourelatos Z....Biegel J.A. (Genomics 1995)
    4. Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects. (PubMed id 19844255)1, 4 Dastani Z....Genest J. (Eur. J. Hum. Genet. 2010)
    5. A pilot genome-wide association study of early-onset breast cancer. (PubMed id 18463975)1, 4 Kibriya M.G....Ahsan H. (Breast Cancer Res. Treat. 2009)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. (PubMed id 12754519)1, 2 Zhang H.... Aebersold R. (Nat. Biotechnol. 2003)
    8. The E-selectin-ligand ESL-1 is a variant of a receptor for fibroblast growth factor. (PubMed id 7531823)1, 3 Steegmaier M....Vestweber D. (Nature 1995)
    9. Immunocytochemical visualization of the Golgi apparatus in several species, including human, and tissues with an antiserum against MG- 160, a sialoglycoprotein of rat Golgi apparatus. (PubMed id 2355176)1, 2 Croul S.... Gonatas N.K. (J. Histochem. Cytochem. 1990)
    10. A novel isoform of human Golgi complex-localized glycoprotein-1 (also known as E-selectin ligand-1, MG-160 and cysteine-rich fibroblast growth factor receptor) targets differential subcellular localization. (PubMed id 15797922)1, 9 Ahn J....Silverstein R.L. (J. Cell. Sci. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2734 HGNC: 4316 AceView: GLG1 Ensembl:ENSG00000090863 euGenes: HUgn2734
    ECgene: GLG1 Kegg: 2734 H-InvDB: GLG1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for GLG1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for GLG1 gene:
    Search GeneIP for patents involving GLG1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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