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Aliases for GLG1 Gene

Aliases for GLG1 Gene

  • Golgi Glycoprotein 1 2 3
  • Cysteine-Rich Fibroblast Growth Factor Receptor 3 4
  • Golgi Sialoglycoprotein MG-160 3 4
  • Golgi Apparatus Protein 1 2 3
  • E-Selectin Ligand 1 3 4
  • CFR-1 3 4
  • ESL-1 3 4
  • MG160 3 4
  • MG-160 3
  • CFR1 4
  • ESL1 4

External Ids for GLG1 Gene

Summaries for GLG1 Gene

GeneCards Summary for GLG1 Gene

GLG1 (Golgi Glycoprotein 1) is a Protein Coding gene. Among its related pathways are ERK Signaling and GPCR Pathway. GO annotations related to this gene include receptor binding.

UniProtKB/Swiss-Prot for GLG1 Gene

  • Binds fibroblast growth factor and E-selectin (cell-adhesion lectin on endothelial cells mediating the binding of neutrophils)

Gene Wiki entry for GLG1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLG1 Gene

Genomics for GLG1 Gene

Genomic Location for GLG1 Gene

Start:
74,447,427 bp from pter
End:
74,607,144 bp from pter
Size:
159,718 bases
Orientation:
Minus strand

Genomic View for GLG1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GLG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLG1 Gene

Regulatory Elements for GLG1 Gene

Proteins for GLG1 Gene

  • Protein details for GLG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92896-GSLG1_HUMAN
    Recommended name:
    Golgi apparatus protein 1
    Protein Accession:
    Q92896
    Secondary Accessions:
    • B7Z8Y4
    • D3DUJ7
    • Q13221
    • Q6P9D1

    Protein attributes for GLG1 Gene

    Size:
    1179 amino acids
    Molecular mass:
    134552 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB02178.1; Type=Frameshift; Positions=27, 35; Evidence={ECO:0000305};

    Alternative splice isoforms for GLG1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GLG1 Gene

Proteomics data for GLG1 Gene at MOPED

Post-translational modifications for GLG1 Gene

  • Fucosylation is essential for binding to E-selectin.
  • N-glycosylated. Contains sialic acid residues (By similarity).
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn165, Asn210, Asn581, Asn677, Thr739, and Asn786

Other Protein References for GLG1 Gene

No data available for DME Specific Peptides for GLG1 Gene

Domains for GLG1 Gene

Protein Domains for GLG1 Gene

Suggested Antigen Peptide Sequences for GLG1 Gene

Graphical View of Domain Structure for InterPro Entry

Q92896

UniProtKB/Swiss-Prot:

GSLG1_HUMAN
Similarity:
  • Contains 16 Cys-rich GLG1 repeats.:
    • Q92896
genes like me logo Genes that share domains with GLG1: view

No data available for Gene Families for GLG1 Gene

Function for GLG1 Gene

Molecular function for GLG1 Gene

GENATLAS Biochemistry: membrane sialoglycoprotein of the Golgi apparatus,binding fibroblast growth factor and E selectin,ubiquitous
UniProtKB/Swiss-Prot Function: Binds fibroblast growth factor and E-selectin (cell-adhesion lectin on endothelial cells mediating the binding of neutrophils)

Gene Ontology (GO) - Molecular Function for GLG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 7531823
genes like me logo Genes that share ontologies with GLG1: view
genes like me logo Genes that share phenotypes with GLG1: view

Animal Models for GLG1 Gene

MGI Knock Outs for GLG1:

miRNA for GLG1 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for GLG1 Gene

Localization for GLG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLG1 Gene

Golgi apparatus membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GLG1 Gene COMPARTMENTS Subcellular localization image for GLG1 gene
Compartment Confidence
golgi apparatus 5
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for GLG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005794 Golgi apparatus IDA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GLG1: view

Pathways for GLG1 Gene

genes like me logo Genes that share pathways with GLG1: view

Pathways by source for GLG1 Gene

Gene Ontology (GO) - Biological Process for GLG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007596 blood coagulation TAS --
GO:0010955 negative regulation of protein processing IEA --
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IEA --
GO:0032330 regulation of chondrocyte differentiation IEA --
GO:0050900 leukocyte migration TAS --
genes like me logo Genes that share ontologies with GLG1: view

Transcripts for GLG1 Gene

Unigene Clusters for GLG1 Gene

Golgi glycoprotein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GLG1 Gene

No ASD Table

Relevant External Links for GLG1 Gene

GeneLoc Exon Structure for
GLG1
ECgene alternative splicing isoforms for
GLG1

Expression for GLG1 Gene

mRNA expression in normal human tissues for GLG1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GLG1 Gene

SOURCE GeneReport for Unigene cluster for GLG1 Gene Hs.109731

mRNA Expression by UniProt/SwissProt for GLG1 Gene

Q92896-GSLG1_HUMAN
Tissue specificity: Widely expressed. Highest levels in pancreas, skeletal muscle, placenta, heart, testis and ovary. Also found in the kidney, liver, lung and brain.
genes like me logo Genes that share expressions with GLG1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for GLG1 Gene

Orthologs for GLG1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GLG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GLG1 35
  • 98.43 (n)
  • 98.41 (a)
GLG1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GLG1 35
  • 90.22 (n)
  • 94.74 (a)
GLG1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GLG1 35
  • 90.95 (n)
  • 96.44 (a)
GLG1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Glg1 35
  • 90.5 (n)
  • 98.79 (a)
Glg1 16
Glg1 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GLG1 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 85 (a)
OneToMany
-- 36
  • 94 (a)
OneToMany
-- 36
  • 99 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Glg1 35
  • 87.9 (n)
  • 94.62 (a)
chicken
(Gallus gallus)
Aves GLG1 35
  • 81.87 (n)
  • 94.21 (a)
GLG1 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GLG1 36
  • 92 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.7363 35
tropical clawed frog
(Silurana tropicalis)
Amphibia glg1 35
  • 75.55 (n)
  • 85.89 (a)
Str.9135 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8564 35
zebrafish
(Danio rerio)
Actinopterygii Dr.12007 35
glg1a 35
  • 73.63 (n)
  • 81.26 (a)
glg1a 36
  • 75 (a)
OneToMany
glg1b 36
  • 83 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001320 35
  • 50.35 (n)
  • 39.81 (a)
fruit fly
(Drosophila melanogaster)
Insecta Glg1 35
  • 47.66 (n)
  • 35.55 (a)
Glg1 36
  • 33 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_F14E5.2 35
  • 46.75 (n)
  • 35.73 (a)
F14E5.2 36
  • 32 (a)
OneToOne
F14E5.2 37
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
OneToMany
-- 36
  • 41 (a)
OneToMany
-- 36
  • 41 (a)
OneToMany
Species with no ortholog for GLG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GLG1 Gene

ENSEMBL:
Gene Tree for GLG1 (if available)
TreeFam:
Gene Tree for GLG1 (if available)

Paralogs for GLG1 Gene

No data available for Paralogs for GLG1 Gene

Variants for GLG1 Gene

Sequence variations from dbSNP and Humsavar for GLG1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1471 -- 74,538,872(+) CACCA(A/C)TAACC intron-variant
rs2438 -- 74,447,588(-) GGTTT(C/G)CTTTC utr-variant-3-prime, nc-transcript-variant
rs7978 -- 74,452,291(-) CAGCC(A/G)TGTCT intron-variant, utr-variant-3-prime, nc-transcript-variant
rs9945 -- 74,456,658(-) AGTTA(C/G/T)GCAGC reference, stop-gained, synonymous-codon, nc-transcript-variant
rs13359 -- 74,448,155(-) CAGAC(C/T)GAATC utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for GLG1 Gene

Variant ID Type Subtype PubMed ID
dgv900e1 CNV Complex 17122850
dgv901e1 CNV Complex 17122850
nsv833277 CNV Loss 17160897
nsv509632 CNV Insertion 20534489
nsv833278 CNV Loss 17160897
nsv833279 CNV Loss 17160897
esv2660806 CNV Deletion 23128226
nsv906905 CNV Gain 21882294
esv32537 CNV Gain 17666407
esv2676990 CNV Deletion 23128226

Relevant External Links for GLG1 Gene

HapMap Linkage Disequilibrium report
GLG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLG1 Gene

Disorders for GLG1 Gene

(2) Novoseek inferred disease relationships for GLG1 Gene

Disease -log(P) Hits PubMed IDs
amyotrophic lateral sclerosis 36.1 1
tumors 3.1 5

Relevant External Links for GLG1

Genetic Association Database (GAD)
GLG1
Human Genome Epidemiology (HuGE) Navigator
GLG1
genes like me logo Genes that share disorders with GLG1: view

No data available for UniProtKB/Swiss-Prot for GLG1 Gene

Publications for GLG1 Gene

  1. Cloning and sequence analysis of the human MG160, a fibroblast growth factor and E-selectin binding membrane sialoglycoprotein of the Golgi apparatus. (PMID: 8985126) Mourelatos Z. … Gonatas N.K. (DNA Cell Biol. 1996) 3 4 23
  2. Latent transforming growth factor-beta complex in Chinese hamster ovary cells contains the multifunctional cysteine-rich fibroblast growth factor receptor, also termed E-selectin-ligand or MG-160. (PMID: 9182700) Olofsson A. … Heldin C.-H. (Biochem. J. 1997) 3 4 23
  3. Assignment of the GLG1 gene for MGF-160, a fibroblast growth factor and E-selectin binding membrane sialoglycoprotein of the Golgi apparatus, to chromosome 16q22-q23 by fluorescence in situ hybridization. (PMID: 8530051) Mourelatos Z. … Biegel J.A. (Genomics 1995) 2 3 23
  4. Expression of E-selectin ligand-1 (CFR/ESL-1) on hepatic stellate cells: implications for leukocyte extravasation and liver metastasis. (PMID: 19148508) Antoine M. … Kiefer P. (Oncol. Rep. 2009) 3 23
  5. Identification of MG-160, a FGF binding medial Golgi sialoglycoprotein, in brain tumors: an index of malignancy in astrocytomas. (PMID: 12684670) Yamaguchi F. … Teramoto A. (Int. J. Oncol. 2003) 3 23

Products for GLG1 Gene

Sources for GLG1 Gene

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