Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GLG1 Gene

Aliases for GLG1 Gene

  • Golgi Glycoprotein 1 2 3 5
  • Cysteine-Rich Fibroblast Growth Factor Receptor 3 4
  • Golgi Sialoglycoprotein MG-160 3 4
  • E-Selectin Ligand 1 3 4
  • CFR-1 3 4
  • ESL-1 3 4
  • MG160 3 4
  • Golgi Apparatus Protein 1 2
  • MG-160 3
  • CFR1 4
  • ESL1 4

External Ids for GLG1 Gene

Previous GeneCards Identifiers for GLG1 Gene

  • GC16U990026
  • GC16M075446
  • GC16M074225
  • GC16M074266
  • GC16M074265
  • GC16M073044
  • GC16M074481
  • GC16M060230

Summaries for GLG1 Gene

GeneCards Summary for GLG1 Gene

GLG1 (Golgi Glycoprotein 1) is a Protein Coding gene. Diseases associated with GLG1 include amyotrophic lateral sclerosis 1. Among its related pathways are Platelet activation, signaling and aggregation and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include receptor binding.

UniProtKB/Swiss-Prot for GLG1 Gene

  • Binds fibroblast growth factor and E-selectin (cell-adhesion lectin on endothelial cells mediating the binding of neutrophils).

Gene Wiki entry for GLG1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLG1 Gene

Genomics for GLG1 Gene

Regulatory Elements for GLG1 Gene

Promoters for GLG1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GLG1 on UCSC Golden Path with GeneCards custom track

Genomic Location for GLG1 Gene

Chromosome:
16
Start:
74,447,427 bp from pter
End:
74,607,144 bp from pter
Size:
159,718 bases
Orientation:
Minus strand

Genomic View for GLG1 Gene

Genes around GLG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GLG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GLG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLG1 Gene

Proteins for GLG1 Gene

  • Protein details for GLG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92896-GSLG1_HUMAN
    Recommended name:
    Golgi apparatus protein 1
    Protein Accession:
    Q92896
    Secondary Accessions:
    • B7Z8Y4
    • D3DUJ7
    • Q13221
    • Q6P9D1

    Protein attributes for GLG1 Gene

    Size:
    1179 amino acids
    Molecular mass:
    134552 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB02178.1; Type=Frameshift; Positions=27, 35; Evidence={ECO:0000305};

    Alternative splice isoforms for GLG1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GLG1 Gene

Proteomics data for GLG1 Gene at MOPED

Post-translational modifications for GLG1 Gene

  • Fucosylation is essential for binding to E-selectin.
  • N-glycosylated. Contains sialic acid residues (By similarity).
  • Glycosylation at Asn 165, Asn 210, Asn 581, Asn 677, Thr 739, and Asn 786
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for GLG1 (Golgi Glycoprotein 1/GLG1)
  • Santa Cruz Biotechnology (SCBT) Antibodies for GLG1

No data available for DME Specific Peptides for GLG1 Gene

Domains & Families for GLG1 Gene

Protein Domains for GLG1 Gene

Suggested Antigen Peptide Sequences for GLG1 Gene

Graphical View of Domain Structure for InterPro Entry

Q92896

UniProtKB/Swiss-Prot:

GSLG1_HUMAN :
  • Contains 16 Cys-rich GLG1 repeats.
Similarity:
  • Contains 16 Cys-rich GLG1 repeats.
genes like me logo Genes that share domains with GLG1: view

No data available for Gene Families for GLG1 Gene

Function for GLG1 Gene

Molecular function for GLG1 Gene

GENATLAS Biochemistry:
membrane sialoglycoprotein of the Golgi apparatus,binding fibroblast growth factor and E selectin,ubiquitous
UniProtKB/Swiss-Prot Function:
Binds fibroblast growth factor and E-selectin (cell-adhesion lectin on endothelial cells mediating the binding of neutrophils).
genes like me logo Genes that share phenotypes with GLG1: view

Animal Models for GLG1 Gene

MGI Knock Outs for GLG1:

Animal Model Products

miRNA for GLG1 Gene

miRTarBase miRNAs that target GLG1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GLG1 Gene

Localization for GLG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLG1 Gene

Golgi apparatus membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GLG1 Gene COMPARTMENTS Subcellular localization image for GLG1 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
plasma membrane 5
cytoskeleton 1
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GLG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with GLG1: view

Pathways & Interactions for GLG1 Gene

genes like me logo Genes that share pathways with GLG1: view

Pathways by source for GLG1 Gene

Gene Ontology (GO) - Biological Process for GLG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010955 negative regulation of protein processing IEA --
genes like me logo Genes that share ontologies with GLG1: view

No data available for SIGNOR curated interactions for GLG1 Gene

Drugs & Compounds for GLG1 Gene

No Compound Related Data Available

Transcripts for GLG1 Gene

Unigene Clusters for GLG1 Gene

Golgi glycoprotein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GLG1 Gene

No ASD Table

Relevant External Links for GLG1 Gene

GeneLoc Exon Structure for
GLG1
ECgene alternative splicing isoforms for
GLG1

Expression for GLG1 Gene

mRNA expression in normal human tissues for GLG1 Gene

Protein differential expression in normal tissues from HIPED for GLG1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GLG1 Gene



SOURCE GeneReport for Unigene cluster for GLG1 Gene Hs.109731

mRNA Expression by UniProt/SwissProt for GLG1 Gene

Q92896-GSLG1_HUMAN
Tissue specificity: Widely expressed. Highest levels in pancreas, skeletal muscle, placenta, heart, testis and ovary. Also found in the kidney, liver, lung and brain.
genes like me logo Genes that share expression patterns with GLG1: view

Protein tissue co-expression partners for GLG1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for GLG1 Gene

Orthologs for GLG1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GLG1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GLG1 35
  • 90.22 (n)
  • 94.74 (a)
GLG1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GLG1 35
  • 90.95 (n)
  • 96.44 (a)
GLG1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Glg1 35
  • 90.5 (n)
  • 98.79 (a)
Glg1 16
Glg1 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GLG1 35
  • 98.43 (n)
  • 98.41 (a)
GLG1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Glg1 35
  • 87.9 (n)
  • 94.62 (a)
oppossum
(Monodelphis domestica)
Mammalia GLG1 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 85 (a)
OneToMany
-- 36
  • 94 (a)
OneToMany
-- 36
  • 99 (a)
OneToMany
chicken
(Gallus gallus)
Aves GLG1 35
  • 81.87 (n)
  • 94.21 (a)
GLG1 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GLG1 36
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia glg1 35
  • 75.55 (n)
  • 85.89 (a)
Str.9135 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.7363 35
zebrafish
(Danio rerio)
Actinopterygii Dr.12007 35
glg1a 35
  • 73.63 (n)
  • 81.26 (a)
glg1a 36
  • 75 (a)
OneToMany
glg1b 36
  • 83 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8564 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001320 35
  • 50.35 (n)
  • 39.81 (a)
fruit fly
(Drosophila melanogaster)
Insecta Glg1 35
  • 47.66 (n)
  • 35.55 (a)
Glg1 36
  • 33 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F14E5.2 37
  • 33 (a)
CELE_F14E5.2 35
  • 46.75 (n)
  • 35.73 (a)
F14E5.2 36
  • 32 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
OneToMany
-- 36
  • 41 (a)
OneToMany
-- 36
  • 41 (a)
OneToMany
Species with no ortholog for GLG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GLG1 Gene

ENSEMBL:
Gene Tree for GLG1 (if available)
TreeFam:
Gene Tree for GLG1 (if available)

Paralogs for GLG1 Gene

No data available for Paralogs for GLG1 Gene

Variants for GLG1 Gene

Sequence variations from dbSNP and Humsavar for GLG1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1471 -- 74,538,872(+) CACCA(A/C)TAACC intron-variant
rs2438 -- 74,447,588(-) GGTTT(C/G)CTTTC nc-transcript-variant, utr-variant-3-prime
rs7978 -- 74,452,291(-) CAGCC(A/G)TGTCT intron-variant, nc-transcript-variant, utr-variant-3-prime
rs9945 -- 74,456,658(-) AGTTA(C/G/T)GCAGC nc-transcript-variant, reference, synonymous-codon
rs13359 -- 74,448,155(-) CAGAC(C/T)GAATC nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for GLG1 Gene

Variant ID Type Subtype PubMed ID
dgv900e1 CNV Complex 17122850
dgv901e1 CNV Complex 17122850
nsv833277 CNV Loss 17160897
nsv509632 CNV Insertion 20534489
nsv833278 CNV Loss 17160897
nsv833279 CNV Loss 17160897
esv2660806 CNV Deletion 23128226
nsv906905 CNV Gain 21882294
esv32537 CNV Gain 17666407
esv2676990 CNV Deletion 23128226

Variation tolerance for GLG1 Gene

Residual Variation Intolerance Score: 1.69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.04; 37.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GLG1 Gene

HapMap Linkage Disequilibrium report
GLG1
Human Gene Mutation Database (HGMD)
GLG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLG1 Gene

Disorders for GLG1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GLG1 Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
amyotrophic lateral sclerosis 1
  • amyotrophic lateral sclerosis
- elite association - COSMIC cancer census association via MalaCards
Search GLG1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GLG1

Genetic Association Database (GAD)
GLG1
Human Genome Epidemiology (HuGE) Navigator
GLG1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GLG1
genes like me logo Genes that share disorders with GLG1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GLG1 Gene

Publications for GLG1 Gene

  1. Cloning and sequence analysis of the human MG160, a fibroblast growth factor and E-selectin binding membrane sialoglycoprotein of the Golgi apparatus. (PMID: 8985126) Mourelatos Z. … Gonatas N.K. (DNA Cell Biol. 1996) 3 4 23 67
  2. Assignment of the GLG1 gene for MGF-160, a fibroblast growth factor and E-selectin binding membrane sialoglycoprotein of the Golgi apparatus, to chromosome 16q22-q23 by fluorescence in situ hybridization. (PMID: 8530051) Mourelatos Z. … Biegel J.A. (Genomics 1995) 2 3 23
  3. Expression of E-selectin ligand-1 (CFR/ESL-1) on hepatic stellate cells: implications for leukocyte extravasation and liver metastasis. (PMID: 19148508) Antoine M. … Kiefer P. (Oncol. Rep. 2009) 3 23
  4. A novel isoform of human Golgi complex-localized glycoprotein-1 (also known as E-selectin ligand-1, MG-160 and cysteine-rich fibroblast growth factor receptor) targets differential subcellular localization. (PMID: 15797922) Ahn J. … Silverstein R.L. (J. Cell. Sci. 2005) 3 23
  5. Identification of MG-160, a FGF binding medial Golgi sialoglycoprotein, in brain tumors: an index of malignancy in astrocytomas. (PMID: 12684670) Yamaguchi F. … Teramoto A. (Int. J. Oncol. 2003) 3 23

Products for GLG1 Gene

Sources for GLG1 Gene

Back to Top

Content