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Aliases for GLG1 Gene

Aliases for GLG1 Gene

  • Golgi Glycoprotein 1 2 3 5
  • Cysteine-Rich Fibroblast Growth Factor Receptor 3 4
  • Golgi Sialoglycoprotein MG-160 3 4
  • Golgi Apparatus Protein 1 2 3
  • E-Selectin Ligand 1 3 4
  • CFR-1 3 4
  • ESL-1 3 4
  • MG160 3 4
  • MG-160 3
  • CFR1 4
  • ESL1 4

External Ids for GLG1 Gene

Previous GeneCards Identifiers for GLG1 Gene

  • GC16U990026
  • GC16M075446
  • GC16M074225
  • GC16M074266
  • GC16M074265
  • GC16M073044
  • GC16M074481
  • GC16M060230

Summaries for GLG1 Gene

GeneCards Summary for GLG1 Gene

GLG1 (Golgi Glycoprotein 1) is a Protein Coding gene. Diseases associated with GLG1 include Amyotrophic Lateral Sclerosis 1. Among its related pathways are Cell surface interactions at the vascular wall and Phospholipase-C Pathway. GO annotations related to this gene include receptor binding.

UniProtKB/Swiss-Prot for GLG1 Gene

  • Binds fibroblast growth factor and E-selectin (cell-adhesion lectin on endothelial cells mediating the binding of neutrophils).

Gene Wiki entry for GLG1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLG1 Gene

Genomics for GLG1 Gene

Regulatory Elements for GLG1 Gene

Enhancers for GLG1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F074573 1.1 Ensembl 32.8 +33.0 33044 1.4 ATF1 PKNOX1 ARNT ZFP64 FEZF1 DMAP1 ZNF48 YY1 SLC30A9 ZNF207 GLG1 RFWD3 RNU6-237P ENSG00000261783 GC16P074552
GH16F074562 1.2 Ensembl ENCODE 28.9 +43.0 43044 4.2 PKNOX1 ATF1 ARNT CREB3L1 FEZF1 FOS JUNB REST ZNF518A MEF2D GLG1 RFWD3 RNU6-237P GC16P074552
GH16F074577 1.2 Ensembl ENCODE 26.7 +28.8 28844 2.6 ZFP64 FEZF1 GTF3C2 FOS SP3 YY2 JUNB REST TSHZ1 ZNF518A RFWD3 GLG1 RPL21P118 ENSG00000214331 ENSG00000259972 ENSG00000260884 CFDP1 TMEM231 ENSG00000261783 RNU6-237P
GH16F074567 0.9 Ensembl ENCODE 27.5 +38.7 38687 2.7 BCOR KLF1 PKNOX1 HLF GATA3 HMBOX1 ZBTB33 CUX1 MLLT1 GLG1 RFWD3 RNU6-237P GC16P074552
GH16F075432 1.2 ENCODE 19.8 -826.6 -826583 2.4 PKNOX1 ARNT CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ENSG00000261783 GLG1 RFWD3 ADAT1 CFDP1 ENSG00000274220
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GLG1 on UCSC Golden Path with GeneCards custom track

Promoters for GLG1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for GLG1 Gene

74,447,427 bp from pter
74,607,144 bp from pter
159,718 bases
Minus strand

Genomic View for GLG1 Gene

Genes around GLG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GLG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GLG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLG1 Gene

Proteins for GLG1 Gene

  • Protein details for GLG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Golgi apparatus protein 1
    Protein Accession:
    Secondary Accessions:
    • B7Z8Y4
    • D3DUJ7
    • Q13221
    • Q6P9D1

    Protein attributes for GLG1 Gene

    1179 amino acids
    Molecular mass:
    134552 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAB02178.1; Type=Frameshift; Positions=27, 35; Evidence={ECO:0000305};

    Alternative splice isoforms for GLG1 Gene


neXtProt entry for GLG1 Gene

Post-translational modifications for GLG1 Gene

  • Fucosylation is essential for binding to E-selectin.
  • N-glycosylated. Contains sialic acid residues (By similarity).
  • Glycosylation at Asn 165, Asn 210, Asn 581, Asn 677, Thr 739, and Asn 786
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for GLG1 (Golgi Glycoprotein 1/GLG1)

No data available for DME Specific Peptides for GLG1 Gene

Domains & Families for GLG1 Gene

Protein Domains for GLG1 Gene

Suggested Antigen Peptide Sequences for GLG1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 16 Cys-rich GLG1 repeats.
  • Contains 16 Cys-rich GLG1 repeats.
genes like me logo Genes that share domains with GLG1: view

No data available for Gene Families for GLG1 Gene

Function for GLG1 Gene

Molecular function for GLG1 Gene

GENATLAS Biochemistry:
membrane sialoglycoprotein of the Golgi apparatus,binding fibroblast growth factor and E selectin,ubiquitous
UniProtKB/Swiss-Prot Function:
Binds fibroblast growth factor and E-selectin (cell-adhesion lectin on endothelial cells mediating the binding of neutrophils).

Gene Ontology (GO) - Molecular Function for GLG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 7531823
GO:0017134 fibroblast growth factor binding IBA --
genes like me logo Genes that share ontologies with GLG1: view
genes like me logo Genes that share phenotypes with GLG1: view

Animal Models for GLG1 Gene

MGI Knock Outs for GLG1:

Animal Model Products

miRNA for GLG1 Gene

miRTarBase miRNAs that target GLG1

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GLG1 Gene

Localization for GLG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLG1 Gene

Golgi apparatus membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GLG1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
golgi apparatus 5
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for GLG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005794 Golgi apparatus IDA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with GLG1: view

Pathways & Interactions for GLG1 Gene

genes like me logo Genes that share pathways with GLG1: view

Gene Ontology (GO) - Biological Process for GLG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010955 negative regulation of protein processing IEA --
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IEA --
GO:0032330 regulation of chondrocyte differentiation IEA --
GO:0050900 leukocyte migration TAS --
GO:0060349 bone morphogenesis IEA --
genes like me logo Genes that share ontologies with GLG1: view

No data available for SIGNOR curated interactions for GLG1 Gene

Transcripts for GLG1 Gene

Unigene Clusters for GLG1 Gene

Golgi glycoprotein 1:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GLG1 Gene

No ASD Table

Relevant External Links for GLG1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GLG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GLG1 Gene

Protein differential expression in normal tissues from HIPED for GLG1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GLG1 Gene

Protein tissue co-expression partners for GLG1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GLG1 Gene:


SOURCE GeneReport for Unigene cluster for GLG1 Gene:


mRNA Expression by UniProt/SwissProt for GLG1 Gene:

Tissue specificity: Widely expressed. Highest levels in pancreas, skeletal muscle, placenta, heart, testis and ovary. Also found in the kidney, liver, lung and brain.
genes like me logo Genes that share expression patterns with GLG1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for GLG1 Gene

Orthologs for GLG1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GLG1 Gene

Organism Taxonomy Gene Similarity Type Details
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 99 (a)
-- 35
  • 94 (a)
-- 35
  • 85 (a)
(Pan troglodytes)
Mammalia GLG1 34 35
  • 98.43 (n)
(Monodelphis domestica)
Mammalia GLG1 35
  • 96 (a)
(Canis familiaris)
Mammalia GLG1 34 35
  • 90.95 (n)
(Mus musculus)
Mammalia Glg1 34 16 35
  • 90.5 (n)
(Bos Taurus)
Mammalia GLG1 34 35
  • 90.22 (n)
(Rattus norvegicus)
Mammalia Glg1 34
  • 87.9 (n)
(Gallus gallus)
Aves GLG1 34 35
  • 81.87 (n)
(Anolis carolinensis)
Reptilia GLG1 35
  • 92 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia glg1 34
  • 75.55 (n)
Str.9135 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.7363 34
(Danio rerio)
Actinopterygii glg1b 35
  • 83 (a)
glg1a 34 35
  • 73.63 (n)
Dr.12007 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8564 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001320 34
  • 50.35 (n)
fruit fly
(Drosophila melanogaster)
Insecta Glg1 34 35
  • 47.66 (n)
(Caenorhabditis elegans)
Secernentea CELE_F14E5.2 34
  • 46.75 (n)
F14E5.2 36 35
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 49 (a)
-- 35
  • 41 (a)
-- 35
  • 41 (a)
Species where no ortholog for GLG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GLG1 Gene

Gene Tree for GLG1 (if available)
Gene Tree for GLG1 (if available)

Paralogs for GLG1 Gene

No data available for Paralogs for GLG1 Gene

Variants for GLG1 Gene

Sequence variations from dbSNP and Humsavar for GLG1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1005715 -- 74,480,134(+) CAAAA(C/T)AGTCT intron-variant
rs1019572 -- 74,466,542(-) TGTTC(C/G)TCAAC intron-variant
rs1019573 -- 74,466,478(-) CCTGC(C/G)ATAGC intron-variant
rs1035575 -- 74,484,323(-) aaaaa(A/T)CAGTT intron-variant
rs10400930 -- 74,592,090(+) TGGCC(G/T)CCTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GLG1 Gene

Variant ID Type Subtype PubMed ID
nsv984354 CNV duplication 23825009
nsv833279 CNV loss 17160897
nsv833278 CNV loss 17160897
nsv833277 CNV loss 17160897
nsv509632 CNV insertion 20534489
nsv1065964 CNV gain 25217958
nsv1056566 CNV loss 25217958
esv3639073 CNV gain 21293372
esv3639070 CNV loss 21293372
esv3639069 CNV gain 21293372
esv3639068 CNV loss 21293372
esv3639067 CNV gain 21293372
esv3571587 CNV gain 25503493
esv3406584 CNV insertion 20981092
esv32537 CNV gain 17666407
esv2762054 CNV gain 21179565
esv2758656 CNV gain+loss 17122850
esv2676990 CNV deletion 23128226
esv2660806 CNV deletion 23128226
dgv535e214 CNV loss 21293372

Variation tolerance for GLG1 Gene

Residual Variation Intolerance Score: 1.69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.04; 37.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GLG1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLG1 Gene

Disorders for GLG1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GLG1 Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
amyotrophic lateral sclerosis 1
  • amyotrophic lateral sclerosis
- elite association - COSMIC cancer census association via MalaCards
Search GLG1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GLG1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GLG1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GLG1 Gene

Publications for GLG1 Gene

  1. Latent transforming growth factor-beta complex in Chinese hamster ovary cells contains the multifunctional cysteine-rich fibroblast growth factor receptor, also termed E-selectin-ligand or MG-160. (PMID: 9182700) Olofsson A. … Heldin C.-H. (Biochem. J. 1997) 3 4 22 64
  2. Cloning and sequence analysis of the human MG160, a fibroblast growth factor and E-selectin binding membrane sialoglycoprotein of the Golgi apparatus. (PMID: 8985126) Mourelatos Z. … Gonatas N.K. (DNA Cell Biol. 1996) 3 4 22 64
  3. Assignment of the GLG1 gene for MGF-160, a fibroblast growth factor and E-selectin binding membrane sialoglycoprotein of the Golgi apparatus, to chromosome 16q22-q23 by fluorescence in situ hybridization. (PMID: 8530051) Mourelatos Z. … Biegel J.A. (Genomics 1995) 2 3 22 64
  4. Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects. (PMID: 19844255) Dastani Z. … Genest J. (Eur. J. Hum. Genet. 2010) 3 46 64
  5. Expression of E-selectin ligand-1 (CFR/ESL-1) on hepatic stellate cells: implications for leukocyte extravasation and liver metastasis. (PMID: 19148508) Antoine M. … Kiefer P. (Oncol. Rep. 2009) 3 22 64

Products for GLG1 Gene

Sources for GLG1 Gene

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