Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GLG1 Gene

Aliases for GLG1 Gene

  • Golgi Glycoprotein 1 2 3 5
  • Cysteine-Rich Fibroblast Growth Factor Receptor 3 4
  • Golgi Sialoglycoprotein MG-160 3 4
  • Golgi Apparatus Protein 1 2 3
  • E-Selectin Ligand 1 3 4
  • CFR-1 3 4
  • ESL-1 3 4
  • MG160 3 4
  • MG-160 3
  • CFR1 4
  • ESL1 4

External Ids for GLG1 Gene

Previous GeneCards Identifiers for GLG1 Gene

  • GC16U990026
  • GC16M075446
  • GC16M074225
  • GC16M074266
  • GC16M074265
  • GC16M073044
  • GC16M074481
  • GC16M060230

Summaries for GLG1 Gene

GeneCards Summary for GLG1 Gene

GLG1 (Golgi Glycoprotein 1) is a Protein Coding gene. Diseases associated with GLG1 include Muscular Dystrophy-Dystroglycanopathy , Type B, 5 and Amyotrophic Lateral Sclerosis 1. Among its related pathways are p70S6K Signaling and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include receptor binding.

UniProtKB/Swiss-Prot for GLG1 Gene

  • Binds fibroblast growth factor and E-selectin (cell-adhesion lectin on endothelial cells mediating the binding of neutrophils).

Gene Wiki entry for GLG1 Gene

Additional gene information for GLG1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLG1 Gene

Genomics for GLG1 Gene

Regulatory Elements for GLG1 Gene

Enhancers for GLG1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H074562 1.2 Ensembl ENCODE 27.6 +43.4 43371 1 HDAC1 HDGF PKNOX1 ATF1 ARNT TCF12 SCRT2 FOS ATF7 CREM GLG1 RFWD3 RNU6-237P GC16P074552
GH16H074577 1.2 Ensembl ENCODE 26.7 +28.8 28816 1 FEZF1 GTF3C2 ATF7 FOS SP3 YY2 JUNB REST TSHZ1 ZNF518A RFWD3 GLG1 WDR59 ENSG00000260884 ENSG00000214331 ENSG00000261079 NPIPB15 RPL21P118 ENSG00000259972 ENSG00000261783
GH16H075432 1.2 ENCODE 20 -826.6 -826583 2 PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ENSG00000261783 CFDP1 GLG1 KARS RFWD3 ADAT1 TMEM231 ENSG00000274220
GH16H074997 1.9 FANTOM5 Ensembl ENCODE dbSUPER 9.7 -395.0 -395022 8 PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ENSG00000214331 ENSG00000261783 ENSG00000259972 ENSG00000207525 RFWD3 ENSG00000260884 RPL21P118 TMEM231 GLG1 ZNRF1
GH16H074594 1.1 Ensembl ENCODE 14.1 +12.5 12469 1 PKNOX1 ZNF792 JUN FOSL1 ZNF316 ZNF600 PRDM10 NFE2 FOS SMARCE1 RFWD3 GLG1 RNU6-237P GC16P074552
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GLG1 on UCSC Golden Path with GeneCards custom track

Promoters for GLG1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000087895 644 2601 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143

Genomic Location for GLG1 Gene

Chromosome:
16
Start:
74,447,427 bp from pter
End:
74,607,144 bp from pter
Size:
159,718 bases
Orientation:
Minus strand

Genomic View for GLG1 Gene

Genes around GLG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GLG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GLG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLG1 Gene

Proteins for GLG1 Gene

  • Protein details for GLG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92896-GSLG1_HUMAN
    Recommended name:
    Golgi apparatus protein 1
    Protein Accession:
    Q92896
    Secondary Accessions:
    • B7Z8Y4
    • D3DUJ7
    • Q13221
    • Q6P9D1

    Protein attributes for GLG1 Gene

    Size:
    1179 amino acids
    Molecular mass:
    134552 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB02178.1; Type=Frameshift; Positions=27, 35; Evidence={ECO:0000305};

    Alternative splice isoforms for GLG1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GLG1 Gene

Post-translational modifications for GLG1 Gene

  • Fucosylation is essential for binding to E-selectin.
  • N-glycosylated. Contains sialic acid residues (By similarity).
  • Glycosylation at posLast=165165, isoforms=2, 3210, isoforms=2, 3581, isoforms=2, 3677, isoforms=2, 3739, and isoforms=2, 3786
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GLG1 Gene

Domains & Families for GLG1 Gene

Gene Families for GLG1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for GLG1 Gene

Suggested Antigen Peptide Sequences for GLG1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GLG1: view

No data available for UniProtKB/Swiss-Prot for GLG1 Gene

Function for GLG1 Gene

Molecular function for GLG1 Gene

GENATLAS Biochemistry:
membrane sialoglycoprotein of the Golgi apparatus,binding fibroblast growth factor and E selectin,ubiquitous
UniProtKB/Swiss-Prot Function:
Binds fibroblast growth factor and E-selectin (cell-adhesion lectin on endothelial cells mediating the binding of neutrophils).

Phenotypes From GWAS Catalog for GLG1 Gene

Gene Ontology (GO) - Molecular Function for GLG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 7531823
GO:0017134 fibroblast growth factor binding IBA --
genes like me logo Genes that share ontologies with GLG1: view
genes like me logo Genes that share phenotypes with GLG1: view

Animal Models for GLG1 Gene

MGI Knock Outs for GLG1:

Animal Model Products

CRISPR Products

miRNA for GLG1 Gene

miRTarBase miRNAs that target GLG1

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for GLG1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GLG1 Gene

Localization for GLG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLG1 Gene

Golgi apparatus membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GLG1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
golgi apparatus 5
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GLG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IBA --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005794 Golgi apparatus IDA,IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IDA,IEA 19946888
genes like me logo Genes that share ontologies with GLG1: view

Pathways & Interactions for GLG1 Gene

genes like me logo Genes that share pathways with GLG1: view

Gene Ontology (GO) - Biological Process for GLG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010955 negative regulation of protein processing IEA --
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IEA --
GO:0032330 regulation of chondrocyte differentiation IEA --
GO:0050900 leukocyte migration TAS --
GO:0060349 bone morphogenesis IEA --
genes like me logo Genes that share ontologies with GLG1: view

No data available for SIGNOR curated interactions for GLG1 Gene

Drugs & Compounds for GLG1 Gene

No Compound Related Data Available

Transcripts for GLG1 Gene

Unigene Clusters for GLG1 Gene

Golgi glycoprotein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for GLG1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for GLG1 Gene

No ASD Table

Relevant External Links for GLG1 Gene

GeneLoc Exon Structure for
GLG1
ECgene alternative splicing isoforms for
GLG1

Expression for GLG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GLG1 Gene

Protein differential expression in normal tissues from HIPED for GLG1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GLG1 Gene



Protein tissue co-expression partners for GLG1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GLG1 Gene:

GLG1

SOURCE GeneReport for Unigene cluster for GLG1 Gene:

Hs.109731

mRNA Expression by UniProt/SwissProt for GLG1 Gene:

Q92896-GSLG1_HUMAN
Tissue specificity: Widely expressed. Highest levels in pancreas, skeletal muscle, placenta, heart, testis and ovary. Also found in the kidney, liver, lung and brain.

Evidence on tissue expression from TISSUES for GLG1 Gene

  • Nervous system(4.9)
  • Blood(4.4)
  • Liver(4.4)
  • Lung(2.7)
  • Adrenal gland(2.5)
  • Intestine(2.5)
  • Kidney(2.2)
  • Heart(2.1)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with GLG1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for GLG1 Gene

Orthologs for GLG1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GLG1 Gene

Organism Taxonomy Gene Similarity Type Details
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 99 (a)
OneToMany
-- 34
  • 94 (a)
OneToMany
-- 34
  • 85 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia GLG1 33 34
  • 98.43 (n)
oppossum
(Monodelphis domestica)
Mammalia GLG1 34
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GLG1 33 34
  • 90.95 (n)
mouse
(Mus musculus)
Mammalia Glg1 33 16 34
  • 90.5 (n)
cow
(Bos Taurus)
Mammalia GLG1 33 34
  • 90.22 (n)
rat
(Rattus norvegicus)
Mammalia Glg1 33
  • 87.9 (n)
chicken
(Gallus gallus)
Aves GLG1 33 34
  • 81.87 (n)
lizard
(Anolis carolinensis)
Reptilia GLG1 34
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia glg1 33
  • 75.55 (n)
Str.9135 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.7363 33
zebrafish
(Danio rerio)
Actinopterygii glg1b 34
  • 83 (a)
OneToMany
glg1a 33 34
  • 73.63 (n)
Dr.12007 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8564 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001320 33
  • 50.35 (n)
fruit fly
(Drosophila melanogaster)
Insecta Glg1 33 34
  • 47.66 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_F14E5.2 33
  • 46.75 (n)
F14E5.2 35 34
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 49 (a)
OneToMany
-- 34
  • 41 (a)
OneToMany
-- 34
  • 41 (a)
OneToMany
Species where no ortholog for GLG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GLG1 Gene

ENSEMBL:
Gene Tree for GLG1 (if available)
TreeFam:
Gene Tree for GLG1 (if available)

Paralogs for GLG1 Gene

No data available for Paralogs for GLG1 Gene

Variants for GLG1 Gene

Sequence variations from dbSNP and Humsavar for GLG1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000005265 -- 74,463,153(+) TTCTG(A/G)TTCTT intron-variant
rs1000008857 -- 74,582,795(+) AGCCT(C/G)GGTGA intron-variant
rs1000017853 -- 74,560,538(+) GGGTT(C/T)CAGCA intron-variant
rs1000038585 -- 74,483,518(+) ACTCC(A/G)TCATT intron-variant
rs1000041766 -- 74,529,457(+) TTTCC(C/T)CTATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GLG1 Gene

Variant ID Type Subtype PubMed ID
dgv535e214 CNV loss 21293372
esv2660806 CNV deletion 23128226
esv2676990 CNV deletion 23128226
esv2758656 CNV gain+loss 17122850
esv2762054 CNV gain 21179565
esv32537 CNV gain 17666407
esv3406584 CNV insertion 20981092
esv3571587 CNV gain 25503493
esv3639067 CNV gain 21293372
esv3639068 CNV loss 21293372
esv3639069 CNV gain 21293372
esv3639070 CNV loss 21293372
esv3639073 CNV gain 21293372
nsv1056566 CNV loss 25217958
nsv1065964 CNV gain 25217958
nsv509632 CNV insertion 20534489
nsv833277 CNV loss 17160897
nsv833278 CNV loss 17160897
nsv833279 CNV loss 17160897
nsv984354 CNV duplication 23825009

Variation tolerance for GLG1 Gene

Residual Variation Intolerance Score: 1.69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.04; 37.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GLG1 Gene

Human Gene Mutation Database (HGMD)
GLG1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GLG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLG1 Gene

Disorders for GLG1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for GLG1 Gene - From: HGMD, DISEASES, and Novoseek

Disorder Aliases PubMed IDs
muscular dystrophy-dystroglycanopathy , type b, 5
  • muscular dystrophy-dystroglycanopathy type b5
amyotrophic lateral sclerosis 1
  • amyotrophic lateral sclerosis
- elite association - COSMIC cancer census association via MalaCards
Search GLG1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GLG1

Genetic Association Database (GAD)
GLG1
Human Genome Epidemiology (HuGE) Navigator
GLG1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GLG1
genes like me logo Genes that share disorders with GLG1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GLG1 Gene

Publications for GLG1 Gene

  1. Latent transforming growth factor-beta complex in Chinese hamster ovary cells contains the multifunctional cysteine-rich fibroblast growth factor receptor, also termed E-selectin-ligand or MG-160. (PMID: 9182700) Olofsson A … Heldin CH (The Biochemical journal 1997) 3 4 22 60
  2. Cloning and sequence analysis of the human MG160, a fibroblast growth factor and E-selectin binding membrane sialoglycoprotein of the Golgi apparatus. (PMID: 8985126) Mourelatos Z … Gonatas NK (DNA and cell biology 1996) 3 4 22 60
  3. Assignment of the GLG1 gene for MGF-160, a fibroblast growth factor and E-selectin binding membrane sialoglycoprotein of the Golgi apparatus, to chromosome 16q22-q23 by fluorescence in situ hybridization. (PMID: 8530051) Mourelatos Z … Biegel JA (Genomics 1995) 2 3 22 60
  4. Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects. (PMID: 19844255) Dastani Z … Genest J (European journal of human genetics : EJHG 2010) 3 45 60
  5. Expression of E-selectin ligand-1 (CFR/ESL-1) on hepatic stellate cells: implications for leukocyte extravasation and liver metastasis. (PMID: 19148508) Antoine M … Kiefer P (Oncology reports 2009) 3 22 60

Products for GLG1 Gene

Sources for GLG1 Gene

Content
Loading form....