Aliases for GLDN Gene
External Ids for GLDN Gene
Previous HGNC Symbols for GLDN Gene
Previous GeneCards Identifiers for GLDN Gene
GeneCards Summary for GLDN Gene
GLDN (Gliomedin) is a Protein Coding gene. GO annotations related to this gene include protein binding involved in heterotypic cell-cell adhesion. An important paralog of this gene is OLFM1.
UniProtKB/Swiss-Prot for GLDN Gene
Ligand for NRCAM and NFASC/neurofascin that plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Mediates interaction between Schwann cell microvilli and axons via its interactions with NRCAM and NFASC. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with NRCAM, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier.