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Aliases for GLDN Gene

Aliases for GLDN Gene

  • Gliomedin 2 3
  • Collomin 2 3
  • COLM 3 4
  • Colmedin 3
  • UNC-112 3
  • CRG-L2 3
  • CRGL2 3
  • CLOM 3

External Ids for GLDN Gene

Previous HGNC Symbols for GLDN Gene

  • COLM

Previous GeneCards Identifiers for GLDN Gene

  • GC15P049422
  • GC15P051633
  • GC15P028463

Summaries for GLDN Gene

GeneCards Summary for GLDN Gene

GLDN (Gliomedin) is a Protein Coding gene. GO annotations related to this gene include protein binding involved in heterotypic cell-cell adhesion. An important paralog of this gene is OLFML3.

UniProtKB/Swiss-Prot for GLDN Gene

  • Ligand for NRCAM and NFASC/neurofascin that plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Mediates interaction between Schwann cell microvilli and axons via its interactions with NRCAM and NFASC. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with NRCAM, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLDN Gene

Genomics for GLDN Gene

Regulatory Elements for GLDN Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GLDN Gene

Chromosome:
15
Start:
51,341,516 bp from pter
End:
51,408,013 bp from pter
Size:
66,498 bases
Orientation:
Plus strand

Genomic View for GLDN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GLDN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLDN Gene

Proteins for GLDN Gene

  • Protein details for GLDN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZMI3-GLDN_HUMAN
    Recommended name:
    Gliomedin
    Protein Accession:
    Q6ZMI3
    Secondary Accessions:
    • Q6UXZ7
    • Q7Z359

    Protein attributes for GLDN Gene

    Size:
    551 amino acids
    Molecular mass:
    58957 Da
    Quaternary structure:
    • Homotrimer (via collagen-like domains). Interacts with NRCAM and NFACS/neurofascin. Interaction with glial NRCAM enhances interaction with axonal NFACS. Interacts with MYOC.

    Alternative splice isoforms for GLDN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GLDN Gene

Proteomics data for GLDN Gene at MOPED

Post-translational modifications for GLDN Gene

  • N-glycosylated.
  • Proteolytic proccessing by a furin-like protease causes shedding of the ectodomain. Further cleavage by BMP1 releases the olfactomedin-like domain.
  • Glycosylation at Asn 130, Asn 329, Asn 357, Asn 378, and Asn 464
  • Modification sites at PhosphoSitePlus

Other Protein References for GLDN Gene

No data available for DME Specific Peptides for GLDN Gene

Domains & Families for GLDN Gene

Suggested Antigen Peptide Sequences for GLDN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZMI3

UniProtKB/Swiss-Prot:

GLDN_HUMAN :
  • The olfactomedin-like domain mediates NFASC/neurofascin and NRCAM binding.
Domain:
  • The olfactomedin-like domain mediates NFASC/neurofascin and NRCAM binding.
  • Contains 2 collagen-like domains.
  • Contains 1 olfactomedin-like domain.
genes like me logo Genes that share domains with GLDN: view

No data available for Gene Families for GLDN Gene

Function for GLDN Gene

Molecular function for GLDN Gene

UniProtKB/Swiss-Prot Function:
Ligand for NRCAM and NFASC/neurofascin that plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Mediates interaction between Schwann cell microvilli and axons via its interactions with NRCAM and NFASC. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with NRCAM, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier.

Gene Ontology (GO) - Molecular Function for GLDN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0086080 protein binding involved in heterotypic cell-cell adhesion IEA --
genes like me logo Genes that share ontologies with GLDN: view
genes like me logo Genes that share phenotypes with GLDN: view

Animal Models for GLDN Gene

MGI Knock Outs for GLDN:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GLDN

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for GLDN Gene

Localization for GLDN Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLDN Gene

Cell membrane; Single-pass type II membrane protein. Note=Detected at the nodes of Ranvier. Detected at immature heminodes. {ECO:0000250 UniProtKB:Q80WL1}.
Gliomedin shedded ectodomain: Secreted. Secreted, extracellular space, extracellular matrix. Note=Proteolytic processing gives rise to a soluble extracellular domain that is secreted. The gliomedin shedded ectodomain localizes to the nodes of Ranvier. {ECO:0000250 UniProtKB:Q80WL1}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GLDN Gene COMPARTMENTS Subcellular localization image for GLDN gene
Compartment Confidence
plasma membrane 5
extracellular 2

Gene Ontology (GO) - Cellular Components for GLDN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005581 collagen trimer IEA --
GO:0005615 extracellular space IEA --
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GLDN: view

Pathways & Interactions for GLDN Gene

SuperPathways for GLDN Gene

No Data Available

Interacting Proteins for GLDN Gene

Selected Interacting proteins: Q6ZMI3-GLDN_HUMAN for GLDN Gene via I2D

Symbol External ID(s) Details
NFASC

Gene Ontology (GO) - Biological Process for GLDN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032528 microvillus organization IEA --
GO:0034113 heterotypic cell-cell adhesion IEA --
GO:0045162 clustering of voltage-gated sodium channels IEA --
genes like me logo Genes that share ontologies with GLDN: view

No data available for Pathways by source and SIGNOR curated interactions for GLDN Gene

Drugs & Compounds for GLDN Gene

No Compound Related Data Available

Transcripts for GLDN Gene

Unigene Clusters for GLDN Gene

Gliomedin:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GLDN

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GLDN Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1:
SP2: -
SP3: - - -
SP4: - -
SP5:

Relevant External Links for GLDN Gene

GeneLoc Exon Structure for
GLDN
ECgene alternative splicing isoforms for
GLDN

Expression for GLDN Gene

mRNA expression in normal human tissues for GLDN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GLDN Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x6.4), Brain - Substantia nigra (x4.8), and Nerve - Tibial (x4.3).

Protein differential expression in normal tissues from HIPED for GLDN Gene

This gene is overexpressed in Serum (64.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GLDN Gene



SOURCE GeneReport for Unigene cluster for GLDN Gene Hs.526441

mRNA Expression by UniProt/SwissProt for GLDN Gene

Q6ZMI3-GLDN_HUMAN
Tissue specificity: Specifically expressed in spinal cord, brain, placenta and sciatic nerve. More abundant in peripheral than central nervous system.
genes like me logo Genes that share expression patterns with GLDN: view

Protein tissue co-expression partners for GLDN Gene

Primer Products

In Situ Assay Products

Orthologs for GLDN Gene

This gene was present in the common ancestor of animals.

Orthologs for GLDN Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GLDN 35
  • 88.35 (n)
  • 90.65 (a)
GLDN 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GLDN 35
  • 88.11 (n)
  • 88.95 (a)
GLDN 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gldn 35
  • 85.95 (n)
  • 86.86 (a)
Gldn 16
Gldn 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GLDN 35
  • 99.27 (n)
  • 98.91 (a)
GLDN 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gldn 35
  • 83.88 (n)
  • 84.85 (a)
oppossum
(Monodelphis domestica)
Mammalia GLDN 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GLDN 36
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves GLDN 35
  • 66.73 (n)
  • 62.09 (a)
GLDN 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 53 (a)
OneToMany
-- 36
  • 43 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia gldn 35
  • 62.21 (n)
  • 59.46 (a)
zebrafish
(Danio rerio)
Actinopterygii gldn 35
  • 53.18 (n)
  • 44.11 (a)
colm 36
  • 42 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6867 36
  • 17 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cof-2 36
  • 20 (a)
ManyToMany
unc-122 36
  • 21 (a)
ManyToMany
Species with no ortholog for GLDN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GLDN Gene

ENSEMBL:
Gene Tree for GLDN (if available)
TreeFam:
Gene Tree for GLDN (if available)

Paralogs for GLDN Gene

Paralogs for GLDN Gene

(10) SIMAP similar genes for GLDN Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GLDN: view

Variants for GLDN Gene

Sequence variations from dbSNP and Humsavar for GLDN Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs725000 -- 51,349,086(-) AGAAT(C/T)GGGAG intron-variant
rs764530 -- 51,369,345(+) AGATA(A/T)GGAAT intron-variant
rs764531 -- 51,369,399(+) TAAAC(A/T)GTGTT intron-variant
rs868475 -- 51,344,257(+) GCTTA(C/T)TCTCC intron-variant
rs898134 -- 51,406,670(-) TCTGT(A/G)TATCC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for GLDN Gene

Variant ID Type Subtype PubMed ID
esv34532 CNV Gain 17911159
dgv747e1 CNV Complex 17122850
nsv471243 CNV Gain 18288195
nsv904215 CNV Gain 21882294
nsv904216 CNV Loss 21882294
nsv94788 CNV Insertion 16902084
nsv904217 CNV Gain 21882294

Variation tolerance for GLDN Gene

Residual Variation Intolerance Score: 84.02% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.11; 90.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GLDN Gene

HapMap Linkage Disequilibrium report
GLDN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLDN Gene

Disorders for GLDN Gene

Relevant External Links for GLDN

Genetic Association Database (GAD)
GLDN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GLDN
genes like me logo Genes that share disorders with GLDN: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GLDN Gene

Publications for GLDN Gene

  1. Gliomedin mediates Schwann cell-axon interaction and the molecular assembly of the nodes of Ranvier. (PMID: 16039564) Eshed Y. … Peles E. (Neuron 2005) 2 23 67
  2. A glial signal consisting of gliomedin and NrCAM clusters axonal Na+ channels during the formation of nodes of Ranvier. (PMID: 20188654) Feinberg K. … Peles E. (Neuron 2010) 23 67
  3. The role of disulfide bonds and alpha-helical coiled-coils in the biosynthesis of type XIII collagen and other collagenous transmembrane proteins. (PMID: 17344215) Snellman A. … Pihlajaniemi T. (J. Biol. Chem. 2007) 23 67
  4. Secreted gliomedin is a perinodal matrix component of peripheral nerves. (PMID: 17485493) Eshed Y. … Peles E. (J. Cell Biol. 2007) 23 67
  5. Cleavage and oligomerization of gliomedin, a transmembrane collagen required for node of ranvier formation. (PMID: 17293346) Maertens B. … Koch M. (J. Biol. Chem. 2007) 23 67

Products for GLDN Gene

Sources for GLDN Gene

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