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Aliases for GLDN Gene

Aliases for GLDN Gene

  • Gliomedin 2 3
  • Collomin 2 3
  • CRGL2 3 6
  • COLM 3 4
  • Colmedin 3
  • UNC-112 3
  • CRG-L2 3
  • CLOM 3

External Ids for GLDN Gene

Previous Symbols for GLDN Gene

  • COLM

Summaries for GLDN Gene

GeneCards Summary for GLDN Gene

GLDN (Gliomedin) is a Protein Coding gene. GO annotations related to this gene include protein binding involved in heterotypic cell-cell adhesion. An important paralog of this gene is OLFML3.

UniProtKB/Swiss-Prot for GLDN Gene

  • Plays a role in the formation of the nodes of Ranvier along myelinated axons. Probable NRCAM and NFASC/neurofascin ligand which may provide a glial positional clue required for the proper molecular assembly of the nodes of Ranvier (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLDN Gene

Genomics for GLDN Gene

Genomic Location for GLDN Gene

Start:
51,341,516 bp from pter
End:
51,408,013 bp from pter
Size:
66,498 bases
Orientation:
Plus strand

Genomic View for GLDN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GLDN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLDN Gene

Regulatory Elements for GLDN Gene

Proteins for GLDN Gene

  • Protein details for GLDN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZMI3-GLDN_HUMAN
    Recommended name:
    Gliomedin
    Protein Accession:
    Q6ZMI3
    Secondary Accessions:
    • Q6UXZ7
    • Q7Z359

    Protein attributes for GLDN Gene

    Size:
    551 amino acids
    Molecular mass:
    58957 Da
    Quaternary structure:
    • Interacts with NFASC/neurofascin, MYOC and NRCAM.

    Alternative splice isoforms for GLDN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GLDN Gene

Proteomics data for GLDN Gene at MOPED

Post-translational modifications for GLDN Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn130, Asn329, Asn357, Asn378, and Asn464

Other Protein References for GLDN Gene

No data available for DME Specific Peptides for GLDN Gene

Domains for GLDN Gene

Protein Domains for GLDN Gene

UniProtKB/Swiss-Prot:

GLDN_HUMAN
Domain:
  • The olfactomedin-like domain mediates NFASC/neurofascin and NRCAM binding.:
    • Q6ZMI3
  • Contains 2 collagen-like domains.:
    • Q6ZMI3
  • Contains 1 olfactomedin-like domain.:
    • Q6ZMI3
genes like me logo Genes that share domains with GLDN: view

No data available for Gene Families for GLDN Gene

Function for GLDN Gene

Molecular function for GLDN Gene

UniProtKB/Swiss-Prot Function: Plays a role in the formation of the nodes of Ranvier along myelinated axons. Probable NRCAM and NFASC/neurofascin ligand which may provide a glial positional clue required for the proper molecular assembly of the nodes of Ranvier (By similarity).

Gene Ontology (GO) - Molecular Function for GLDN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0086080 protein binding involved in heterotypic cell-cell adhesion IEA --
genes like me logo Genes that share ontologies with GLDN: view

Phenotypes for GLDN Gene

genes like me logo Genes that share phenotypes with GLDN: view

Animal Models for GLDN Gene

MGI Knock Outs for GLDN:

miRNA for GLDN Gene

miRTarBase miRNAs that target GLDN

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for GLDN Gene

Localization for GLDN Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLDN Gene

Cell membrane; Single-pass type II membrane protein. Note=Localizes to the nodes of Ranvier. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GLDN Gene COMPARTMENTS Subcellular localization image for GLDN gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytosol 1
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for GLDN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005581 collagen trimer IEA --
GO:0005615 extracellular space IEA --
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GLDN: view

Pathways for GLDN Gene

SuperPathways for GLDN Gene

No Data Available

Interacting Proteins for GLDN Gene

Selected Interacting proteins: Q6ZMI3-GLDN_HUMAN for GLDN Gene via I2D

Symbol External ID(s) Details
NFASC

Gene Ontology (GO) - Biological Process for GLDN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032528 microvillus organization IEA --
GO:0034113 heterotypic cell-cell adhesion IEA --
GO:0045162 clustering of voltage-gated sodium channels IEA --
genes like me logo Genes that share ontologies with GLDN: view

No data available for Pathways by source for GLDN Gene

Transcripts for GLDN Gene

Unigene Clusters for GLDN Gene

Gliomedin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GLDN Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1:
SP2: -
SP3: - - -
SP4: - -
SP5:

Relevant External Links for GLDN Gene

GeneLoc Exon Structure for
GLDN
ECgene alternative splicing isoforms for
GLDN

Expression for GLDN Gene

mRNA expression in normal human tissues for GLDN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GLDN Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (6.4), Brain - Substantia nigra (4.8), and Nerve - Tibial (4.3).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for GLDN Gene

SOURCE GeneReport for Unigene cluster for GLDN Gene Hs.526441

mRNA Expression by UniProt/SwissProt for GLDN Gene

Q6ZMI3-GLDN_HUMAN
Tissue specificity: Specifically expressed in spinal cord, brain, placenta and sciatic nerve. More abundant in peripheral than central nervous system.
genes like me logo Genes that share expressions with GLDN: view

Orthologs for GLDN Gene

This gene was present in the common ancestor of animals.

Orthologs for GLDN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GLDN 36
  • 99.27 (n)
  • 98.91 (a)
GLDN 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GLDN 36
  • 88.35 (n)
  • 90.65 (a)
GLDN 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GLDN 36
  • 88.11 (n)
  • 88.95 (a)
GLDN 37
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gldn 36
  • 85.95 (n)
  • 86.86 (a)
Gldn 16
Gldn 37
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GLDN 37
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GLDN 37
  • 53 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gldn 36
  • 83.88 (n)
  • 84.85 (a)
chicken
(Gallus gallus)
Aves GLDN 36
  • 66.73 (n)
  • 62.09 (a)
GLDN 37
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 53 (a)
OneToMany
-- 37
  • 43 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia gldn 36
  • 62.21 (n)
  • 59.46 (a)
zebrafish
(Danio rerio)
Actinopterygii colm 37
  • 42 (a)
OneToOne
gldn 36
  • 53.18 (n)
  • 44.11 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6867 37
  • 17 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cof-2 37
  • 20 (a)
ManyToMany
unc-122 37
  • 21 (a)
ManyToMany
Species with no ortholog for GLDN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GLDN Gene

ENSEMBL:
Gene Tree for GLDN (if available)
TreeFam:
Gene Tree for GLDN (if available)

Paralogs for GLDN Gene

Paralogs for GLDN Gene

Selected SIMAP similar genes for GLDN Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GLDN: view

Variants for GLDN Gene

Sequence variations from dbSNP and Humsavar for GLDN Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs725000 -- 51,349,086(-) AGAAT(C/T)GGGAG intron-variant
rs764530 -- 51,369,345(+) AGATA(A/T)GGAAT intron-variant
rs764531 -- 51,369,399(+) TAAAC(A/T)GTGTT intron-variant
rs868475 -- 51,344,257(+) GCTTA(C/T)TCTCC intron-variant
rs898134 -- 51,406,670(-) TCTGT(A/G)TATCC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for GLDN Gene

Variant ID Type Subtype PubMed ID
esv34532 CNV Gain 17911159
dgv747e1 CNV Complex 17122850
nsv471243 CNV Gain 18288195
nsv904215 CNV Gain 21882294
nsv904216 CNV Loss 21882294
nsv94788 CNV Insertion 16902084
nsv904217 CNV Gain 21882294

Relevant External Links for GLDN Gene

HapMap Linkage Disequilibrium report
GLDN

Disorders for GLDN Gene

(1) University of Copenhagen DISEASES for GLDN Gene

Relevant External Links for GLDN

Genetic Association Database (GAD)
GLDN
genes like me logo Genes that share disorders with GLDN: view

No data available for UniProtKB/Swiss-Prot for GLDN Gene

Publications for GLDN Gene

  1. Gliomedin mediates Schwann cell-axon interaction and the molecular assembly of the nodes of Ranvier. (PMID: 16039564) Eshed Y. … Peles E. (Neuron 2005) 2 3 4 23
  2. Identification and characterization of CRG-L2, a new marker for liver tumor development. (PMID: 12642876) Graveel C.R. … Farnham P.J. (Oncogene 2003) 2 3
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Fibronectin type III-like domains of neurofascin-186 protein mediate gliomedin binding and its clustering at the developing nodes of Ranvier. (PMID: 22009740) Labasque M. … Faivre-Sarrailh C. (J. Biol. Chem. 2011) 3

Products for GLDN Gene

Sources for GLDN Gene

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