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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GLDN Gene

protein-coding   GIFtS: 54
GCID: GC15P051633

Gliomedin

(Previous name: collomin)
(Previous symbol: COLM)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
gliomedin1 2     CLOM2
COLM1 2 3     CRG-L22
collomin1 2     UNC-1122
CRGL22 5     colmedin2

External Ids:    HGNC: 295141   Entrez Gene: 3420352   Ensembl: ENSG000001864177   OMIM: 6086035   UniProtKB: Q6ZMI33   

Export aliases for GLDN gene to outside databases

Previous GC identifers: GC15P049422 GC15P028463


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for GLDN Gene: 
GLDN (gliomedin) is a protein-coding gene. Diseases associated with GLDN include demyelinating polyneuropathy, and polyneuropathy. An important paralog of this gene is OLFM3.

UniProtKB/Swiss-Prot: GLDN_HUMAN, Q6ZMI3
Function: Plays a role in the formation of the nodes of Ranvier along myelinated axons. Probable NRCAM and
NFASC/neurofascin ligand which may provide a glial positional clue required for the proper molecular assembly of
the nodes of Ranvier (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010194.17  NC_018926.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GLDN gene promoter:
         AREB6   AhR   PPAR-gamma1   AML1a   COMP1   PPAR-gamma2   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGLDN promoter sequence
   Search SABiosciences Chromatin IP Primers for GLDN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GLDN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21.2   Ensembl cytogenetic band:  15q21.2   HGNC cytogenetic band: 15q15.3

GLDN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GLDN gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P051633:  view genomic region     (about GC identifiers)

Start:
51,633,713 bp from pter      End:
51,700,210 bp from pter
Size:
66,498 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GLDN_HUMAN, Q6ZMI3 (See protein sequence)
Recommended Name: Gliomedin  
Size: 551 amino acids; 58957 Da
Subunit: Interacts with NFASC/neurofascin and NRCAM (By similarity)
Subcellular location: Cell membrane; Single-pass type II membrane protein. Note=Localizes to the nodes of Ranvier
(By similarity)
Secondary accessions: Q6UXZ7 Q7Z359
Alternative splicing: 2 isoforms:  Q6ZMI3-1   Q6ZMI3-2   

Explore the universe of human proteins at neXtProt for GLDN: NX_Q6ZMI3

Explore proteomics data for GLDN at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6ZMI3

  • GLDN Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GLDN Protein Expression
    REFSEQ proteins: NP_861454.2  
    ENSEMBL proteins: 
     ENSP00000335196   ENSP00000379681   ENSP00000453433  

    Human Recombinant Protein Products for GLDN: 
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    OriGene MassSpec for GLDN 
    OriGene Custom Protein Services for GLDN
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    Novus Biologicals GLDN Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for GLDN 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005581collagen IEA--
    GO:0005615extracellular space IEA--
    GO:0005886plasma membrane IEA--
    GO:0016021integral to membrane IEA--

    GLDN for ontologies           About GeneDecksing



    GLDN Antibody Products: 
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    Novus Biologicals GLDN Antibodies
    Abcam antibodies for GLDN
    Cloud-Clone Corp. Antibodies for GLDN 
    ThermoFisher Antibodies for GLDN
    LSBio Antibodies in human, mouse, rat for GLDN 

    Assay Products for GLDN: 
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    Cloud-Clone Corp. ELISAs for GLDN 
    Cloud-Clone Corp. CLIAs for GLDN


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR003112 Olfac-like
     IPR008160 Collagen

    Graphical View of Domain Structure for InterPro Entry Q6ZMI3

    ProtoNet protein and cluster: Q6ZMI3

    3 Blocks protein domains:
    IPB003112 Olfactomedin-like
    IPB008160 Collagen triple helix repeat
    IPB008161 Collagen helix repeat


    UniProtKB/Swiss-Prot: GLDN_HUMAN, Q6ZMI3
    Domain: The olfactomedin-like domain mediates NFASC/neurofascin and NRCAM binding (By similarity)
    Similarity: Contains 2 collagen-like domains
    Similarity: Contains 1 olfactomedin-like domain


    GLDN for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GLDN_HUMAN, Q6ZMI3
    Function: Plays a role in the formation of the nodes of Ranvier along myelinated axons. Probable NRCAM and
    NFASC/neurofascin ligand which may provide a glial positional clue required for the proper molecular assembly of
    the nodes of Ranvier (By similarity)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0086080protein binding involved in heterotypic cell-cell adhesion IEA--
         
    GLDN for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for GLDN:
     G2 arrest  Increased S DNA content 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Gldn):
     behavior/neurological  mortality/aging  nervous system 

    GLDN for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Gldntm1Pele for GLDN

       inGenious Targeting Laboratory - Custom generated mouse model solutions for GLDN 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GLDN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GLDN 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GLDN 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GLDN
    8/32 QIAGEN miScript miRNA Assays for microRNAs that regulate GLDN (see all 32):
    hsa-miR-3607-5p hsa-miR-607 hsa-miR-3660 hsa-miR-106a hsa-miR-2110 hsa-miR-764 hsa-miR-29b-1* hsa-miR-1304
    SwitchGear 3'UTR luciferase reporter plasmidGLDN 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for GLDN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GLDN

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GLDN
    Sirion Biotech Customized adenovirus for overexpression of GLDN

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for GLDN (see all 7)
    OriGene ORF clones in mouse, rat for GLDN
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    GenScript: all cDNA clones in your preferred vector: GLDN (NM_181789)
    Sino Biological Human cDNA Clone for GLDN
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GLDN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GLDN
    Sirion Biotech Customized lentivirus for stable overexpression of GLDN 
                         Customized lentivirus expression plasmids for stable overexpression of GLDN 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GLDN
    Search LifeMap BioReagents cell lines for GLDN
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GLDN


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GLDN

    1 Interacting protein for GLDN (Q6ZMI33) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NFASCO948563I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007399nervous system development ----
    GO:0030154cell differentiation ----
    GO:0032528microvillus organization IEA--
    GO:0034113heterotypic cell-cell adhesion ----
    GO:0045162clustering of voltage-gated sodium channels IEA--

    GLDN for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GLDN

    Search CenterWatch for drugs/clinical trials and news about GLDN

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GLDN gene: 
    NM_181789.2  

    Unigene Cluster for GLDN:

    Gliomedin
    Hs.526441  [show with all ESTs]
    Unigene Representative Sequence: NM_181789
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000335449(uc002aba.3) ENST00000560215 ENST00000558286 ENST00000560690
    ENST00000559317 ENST00000464150(uc010bez.1) ENST00000396399(uc002abb.3)
    ENST00000561194 ENST00000558426
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GLDN
    8/32 QIAGEN miScript miRNA Assays for microRNAs that regulate GLDN (see all 32):
    hsa-miR-3607-5p hsa-miR-607 hsa-miR-3660 hsa-miR-106a hsa-miR-2110 hsa-miR-764 hsa-miR-29b-1* hsa-miR-1304
    SwitchGear 3'UTR luciferase reporter plasmidGLDN 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for GLDN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GLDN
    Clone
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    OriGene clones in human, mouse for GLDN (see all 7)
    OriGene ORF clones in mouse, rat for GLDN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GLDN (NM_181789)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GLDN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GLDN
    Sirion Biotech Customized lentivirus for stable overexpression of GLDN 
                         Customized lentivirus expression plasmids for stable overexpression of GLDN 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for GLDN
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GLDN
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GLDN
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GLDN

    Additional mRNA sequence: 

    AK095128.1 AK172756.1 AK308933.1 AK310755.1 AY358144.1 BC113397.1 BC113399.1 BX538105.1 

    5 DOTS entries:

    DT.91974209  DT.406569  DT.101963424  DT.40112906  DT.121054945 

    24/43 AceView cDNA sequences (see all 43):

    BX101284 BX337184 AA969362 AI199825 BI756736 CR590325 BX387035 F35834 
    BG623119 AK095128 BX324704 BI551391 AW148870 BX538105 F26898 BQ879885 
    AK023623 BX324705 AK172756 AU138192 NM_181789 AI186284 BI755831 BI552304 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for GLDN    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
    SP1:                                                                                    
    SP2:                          -                                                         
    SP3:              -     -     -                                                         
    SP4:                    -     -                                                         
    SP5:                                                                                    


    ECgene alternative splicing isoforms for GLDN

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GLDN expression in normal human tissues (normalized intensities)      GLDN embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCACCACTG
    GLDN Expression
    About this image


    GLDN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
     
     Dermis (Uncategorized)    fully expand to see all 2 entries
             Human Dermal Fibroblasts-adult (HDF-a)   
     
     Hair
             Human Hair Dermal Papilla Cells (HHDPC)   
     
     Cartilage (Muscoskeletal System)
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
     
     Fibroblast
             Human Dermal Fibroblasts-adult (HDF-a)   

    See GLDN Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GLDN

    SOURCE GeneReport for Unigene cluster: Hs.526441

    UniProtKB/Swiss-Prot: GLDN_HUMAN, Q6ZMI3
    Tissue specificity: Specifically expressed in spinal cord, brain, placenta and sciatic nerve. More abundant in
    peripheral than central nervous system

        SABiosciences Custom PCR Arrays for GLDN
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GLDN
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GLDN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for GLDN gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gldn1 , 5 gliomedin1, 5 85.95(n)1
    86.86(a)1
      9 (29.52 cM)5
    2353791  NM_177350.51  NP_796324.11 
     542864865 
    chicken
    (Gallus gallus)
    Aves GLDN1 gliomedin 67.13(n)
    62.2(a)
      427523  XM_425097.3  XP_425097.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    53(a)
    40(a)
    1 ↔ many
    1 ↔ many
    GL343330.1(454567-455082)
    GL343330.1(464147-489802)
    zebrafish
    (Danio rerio)
    Actinopterygii colm1 collomin 55.51(n)
    48.28(a)
      572018  NM_001080165.2  NP_001073634.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG68671 CG6867 47.9(n)
    35.99(a)
      32782  NM_133034.5  NP_573262.2 
    worm
    (Caenorhabditis elegans)
    Secernentea cof-21 Protein COF-2 43.81(n)
    26.93(a)
      183582  NM_059403.2  NP_491804.2 


    ENSEMBL Gene Tree for GLDN (if available)
    TreeFam Gene Tree for GLDN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GLDN gene
    OLFM32  OLFML32  OLFML2A2  OLFM12  OLFM42  OLFM22  MYOC2  OLFML2B2  
    OLFML12  
    9 SIMAP similar genes for GLDN using alignment to 3 protein entries:     GLDN_HUMAN (see all proteins):
    OLFM1    COL5A1    COL4A3    MARCO    COL13A1    COLEC11
    COL24A1    COL25A1    DKFZp434L081

    GLDN for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1612 SNPs in GLDN are shown (see all 1612)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs10719551,2
    C,F,H--51632812(-) TGGCTC/GTGCTT 1 -- us2k112Minor allele frequency- G:0.22NA WA CSA EA 553
    rs1118695101,2
    C,F--51632861(+) TCTCTG/AAGGAG 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1495593701,2
    --51632866(+) GAGGAA/GACTCA 1 -- us2k10--------
    rs802265131,2
    C,F--51633010(+) CCCAGC/ATCTCC 1 -- us2k11Minor allele frequency- A:0.09WA 118
    rs116309191,2
    C,F,H--51633061(+) ATGCTC/GAAAGC 1 -- us2k112Minor allele frequency- G:0.22NA WA CSA EA 379
    rs1442371101,2
    --51633213(+) AAGGAC/TGAGTC 1 -- us2k10--------
    rs799345021,2
    F--51633262(+) GGGTGG/ACCTTT 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1449893351,2
    C--51633301(+) GCCCC-/TATCCA 1 -- us2k10--------
    rs1399522021,2
    --51633381(+) TGATGC/TGCAGC 1 -- us2k10--------
    rs116311181,2
    C,F,A,H--51633396(+) TGCTCG/AGGCCA 1 -- us2k113Minor allele frequency- A:0.25NS NA WA CSA EA 835

    HapMap Linkage Disequilibrium report for GLDN (51633713 - 51700210 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for GLDN:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv94788CNV Insertion16902084
    nsv904216CNV Loss21882294
    esv34532CNV Gain17911159
    nsv471243CNV Gain18288195
    nsv904215CNV Gain21882294
    nsv904217CNV Gain21882294
    dgv747e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing GLDN
    DNA2.0 Custom Variant and Variant Library Synthesis for GLDN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608603    OMIM disorders: --

    3 diseases for GLDN:    About MalaCards
    demyelinating polyneuropathy    polyneuropathy    neuritis

    1 disease from the University of Copenhagen DISEASES database for GLDN:
    Demyelinating polyneuropathy

    GLDN for disorders           About GeneDecksing

    Genetic Association Database (GAD): GLDN

    Export disorders for GLDN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GLDN gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with GLDN)
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    world of online information

    1. Gliomedin mediates Schwann cell-axon interaction and the molecular assembly of the nodes of Ranvier. (PubMed id 16039564)1, 2, 3, 9 Eshed Y.... Peles E. (2005)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Identification and characterization of CRG-L2, a new marker for liver tumor development. (PubMed id 12642876)1, 3 Graveel C.R....Farnham P.J. (2003)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    5. Nodal proteins are target antigens in Guillain-Barre s yndrome. (PubMed id 22462667)1 Devaux J.J....Yuki N. (2012)
    6. Fibronectin type III-like domains of neurofascin-186 p rotein mediate gliomedin binding and its clustering at the developing nodes of R anvier. (PubMed id 22009740)1 Labasque M....Faivre-Sarrailh C. (2011)
    7. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (2007)
    8. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. Secreted gliomedin is a perinodal matrix component of peripheral nerves. (PubMed id 17485493)9 Eshed Y....Peles E. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 342035 HGNC: 29514 AceView: COLM Ensembl:ENSG00000186417 euGenes: HUgn342035
    ECgene: GLDN H-InvDB: GLDN

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GLDN Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GLDN Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GLDN gene:
    Search GeneIP for patents involving GLDN

    Licensable Technologies for GLDN gene:
    Weizmann Institute:Modulation of Ion-Channel Clustering by Gliomedin
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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