Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GLDC Gene

protein-coding   GIFtS: 66
GCID: GC09M006522

Glycine Dehydrogenase (Decarboxylating)

(Previous names: glycine dehydrogenase (decarboxylating; glycine decarboxylase,...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Glycine Dehydrogenase (Decarboxylating)1 2     HYGN12 5
GCSP2 3 5     Glycine Dehydrogenase (Decarboxylating; Glycine Decarboxylase, Glycine
Cleavage System Protein P)1
Glycine Decarboxylase1 3     Glycine Decarboxylase P-Protein2
Glycine Cleavage System Protein P1 2     Glycine Dehydrogenase [Decarboxylating], Mitochondrial2
EC 1.4.4.23 8     Glycine Cleavage System P Protein3
GCE2 5     NKH5

External Ids:    HGNC: 43131   Entrez Gene: 27312   Ensembl: ENSG000001784457   OMIM: 2383005   UniProtKB: P233783   

Export aliases for GLDC gene to outside databases

Previous GC identifers: GC09M006686 GC09M006513


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GLDC Gene:
Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial
protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic
acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide
dehydrogenase). The protein encoded by this gene is the P protein, which binds to glycine and enables the
methylamine group from glycine to be transferred to the T protein. Defects in this gene are a cause of nonketotic
hyperglycinemia (NKH).(provided by RefSeq, Jan 2010)

GeneCards Summary for GLDC Gene: 
GLDC (glycine dehydrogenase (decarboxylating)) is a protein-coding gene. Diseases associated with GLDC include gldc-related glycine encephalopathy, and glycine encephalopathy, and among its related super-pathways are Metabolism and Biosynthesis of amino acids. GO annotations related to this gene include electron carrier activity and lyase activity.

UniProtKB/Swiss-Prot: GCSP_HUMAN, P23378
Function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino
group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety
is then transferred to the lipoamide cofactor of the H protein

Gene Wiki entry for GLDC (Glycine dehydrogenase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_008413.18  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GLDC gene promoter:
         LHX3b/Lhx3b   Pax-5   Pax-2   MyoD   CUTL1   Pax-2a   C/EBPalpha   AREB6   Pax-2b   LHX3a/Lhx3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGLDC promoter sequence
   Search SABiosciences Chromatin IP Primers for GLDC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GLDC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p22   Ensembl cytogenetic band:  9p24.1   HGNC cytogenetic band: 9p22

GLDC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GLDC gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M006522:  view genomic region     (about GC identifiers)

Start:
6,532,464 bp from pter      End:
6,645,692 bp from pter
Size:
113,229 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GCSP_HUMAN, P23378 (See protein sequence)
Recommended Name: Glycine dehydrogenase [decarboxylating], mitochondrial precursor  
Size: 1020 amino acids; 112730 Da
Cofactor: Pyridoxal phosphate
Subunit: Homodimer. The glycine cleavage system is composed of four proteins: P, T, L and H
Subcellular location: Mitochondrion
Secondary accessions: Q2M2F8

Explore the universe of human proteins at neXtProt for GLDC: NX_P23378

Explore proteomics data for GLDC at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P23378

  • 4/36 DME Specific Peptides for GLDC (P23378) (see all 36)
     GSSQRFG  WDRPYSR  DGANMNA  GPIGVKK 

    GLDC Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GLDC Protein Expression
    REFSEQ proteins: NP_000161.2  
    ENSEMBL proteins: 
     ENSP00000370737  

    Human Recombinant Protein Products for GLDC: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for GLDC
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for GLDC
    GenScript Custom Purified and Recombinant Proteins Services for GLDC
    Novus Biologicals GLDC Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for GLDC 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--

    GLDC for ontologies           About GeneDecksing



    GLDC Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for GLDC 
    OriGene Antibodies for GLDC
    OriGene Custom Antibody Services for GLDC
    GenScript Custom Superior Antibodies Services for GLDC
    Novus Biologicals GLDC Antibodies
    Abcam antibodies for GLDC
    Cloud-Clone Corp. Antibodies for GLDC 
    ThermoFisher Antibody for GLDC
    LSBio Antibodies in human, mouse, rat for GLDC 

    Assay Products for GLDC: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for GLDC
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GLDC
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for GLDC 
    Cloud-Clone Corp. CLIAs for GLDC


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro protein domains (see all 6):
     IPR020581 GDC_P
     IPR001597 ArAA_b-elim_lyase/Thr_aldolase
     IPR020580 GDC-P_N
     IPR003437 GDC_P_homo
     IPR015424 PyrdxlP-dep_Trfase

    Graphical View of Domain Structure for InterPro Entry P23378

    ProtoNet protein and cluster: P23378

    1 Blocks protein domain: IPB003437 Glycine cleavage system P-protein

    UniProtKB/Swiss-Prot: GCSP_HUMAN, P23378
    Similarity: Belongs to the GcvP family


    GLDC for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GCSP_HUMAN, P23378
    Function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino
    group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety
    is then transferred to the lipoamide cofactor of the H protein
    Catalytic activity: Glycine + H-protein-lipoyllysine = H-protein-S-aminomethyldihydrolipoyllysine + CO(2)

         Genatlas biochemistry entry for GLDC:
    glycine decarboxylase pyridoxal-phosphate dependent 120kDa,P protein,catalyzing the first step of the glycine
    cleavage system

         Enzyme Number (IUBMB): EC 1.4.4.21 2

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004375glycine dehydrogenase (decarboxylating) activity IEA--
    GO:0009055electron carrier activity TAS2268343
    GO:0016829lyase activity IEA--
    GO:0030170pyridoxal phosphate binding IEA--
         
    GLDC for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Gldc):
     craniofacial  embryogenesis  growth/size  homeostasis/metabolism  mortality/aging 
     nervous system 

    GLDC for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for GLDC 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GLDC

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GLDC 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GLDC 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GLDC
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate GLDC (see all 11):
    hsa-miR-30c hsa-miR-3163 hsa-miR-146b-3p hsa-miR-30d hsa-miR-410 hsa-miR-188-3p hsa-miR-144 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidGLDC 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for GLDC
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GLDC

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GLDC
    Sirion Biotech Customized adenovirus for overexpression of GLDC

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for GLDC (see all 5)
    OriGene ORF clones in mouse, rat for GLDC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GLDC (NM_000170)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GLDC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GLDC
    Sirion Biotech Customized lentivirus for stable overexpression of GLDC 
                         Customized lentivirus expression plasmids for stable overexpression of GLDC 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GLDC
    Search LifeMap BioReagents cell lines for GLDC
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GLDC


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GLDC About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolic pathways0.40
    2Carbon metabolism
    Carbon metabolism0.37
    3glycine cleavage
    glycine cleavage
    4Glycine, serine and threonine metabolism
    Glycine, serine and threonine metabolism
    5Glucose / Energy Metabolism
    Glucose / Energy Metabolism

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for GLDC
        Glucose / Energy Metabolism

    1 BioSystems Pathway for GLDC
        glycine cleavage


    3         Kegg Pathways  (Kegg details for GLDC):
        Glycine, serine and threonine metabolism
    Metabolic pathways
    Carbon metabolism


    GLDC for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GLDC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/271 Interacting proteins for GLDC (P233782, 3 ENSP000003707374) via UniProtKB, MINT, STRING, and/or I2D (see all 271)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRPEL1Q9HAV72, 3, ENSP000002649544MINT-8079030 I2D: score=1 STRING: ENSP00000264954
    DLDP096222, 3, ENSP000002054024MINT-8079030 I2D: score=1 STRING: ENSP00000205402
    HSPD1P108092, 3, ENSP000003400194MINT-8079030 I2D: score=3 STRING: ENSP00000340019
    TLR10Q9BXR53, ENSP000003089254I2D: score=2 STRING: ENSP00000308925
    TNIP3Q96KP63, ENSP000000575134I2D: score=1 STRING: ENSP00000057513
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006520cellular amino acid metabolic process ----
    GO:0006544glycine metabolic process ----
    GO:0006546glycine catabolic process IEA--
    GO:0055114oxidation-reduction process ----

    GLDC for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GLDC for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GLDC (GCSP)

    7 HMDB Compounds for GLDC    About this table
    CompoundSynonyms CAS #PubMed Ids
    Carbon dioxideCarbon oxide (see all 5)124-38-9--
    Glycine2-Aminoacetate (see all 15)56-40-6--
    LipoamideLipozyme (see all 25)940-69-2--
    MethylamineAminomethane (see all 21)74-89-5--
    Pyridoxal3-Hydroxy-5-(hydroxymethyl)-2-methylpyridine-4-carboxaldehyde (see all 3)66-72-8--
    Pyridoxal 5'-phosphateApolon B6 (see all 27)54-47-7--
    S-aminomethyldihydrolipoamide8-[(aminomethyl)sulfanyl]-6-sulfanyloctanamide ----

    2 DrugBank Compounds for GLDC    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Glycine2-Aminoacetic acid (see all 4)56-40-6target--17496108 17361008 17158739
    Pyridoxal PhosphateCodecarboxylase (see all 9)54-47-7targetcofactor16228305 15791207

    9 Novoseek inferred chemical compound relationships for GLDC gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    saci 66.7 2 1943691 (1), 1671321 (1)
    dihydrolipoamide 63.5 1 15946682 (1)
    alpha lipoic acid 61.3 1 11286922 (1)
    tetrahydrofolate 60 1 11286922 (1)
    polyglycolic acid 54.6 2 16358787 (1), 10375564 (1)
    methionine 40.7 1 15864413 (1)
    nitrate 24.7 2 11514514 (1), 15207493 (1)
    carbon 3.37 2 8647275 (2)
    fatty acid 0 1 15207493 (1)

    Search CenterWatch for drugs/clinical trials and news about GLDC / GCSP

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GLDC gene: 
    NM_000170.2  

    Unigene Cluster for GLDC:

    Glycine dehydrogenase (decarboxylating)
    Hs.584238  [show with all ESTs]
    Unigene Representative Sequence: NM_000170
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000321612(uc003zkc.3) ENST00000477960 ENST00000467946 ENST00000460457
    ENST00000463305
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GLDC
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate GLDC (see all 11):
    hsa-miR-30c hsa-miR-3163 hsa-miR-146b-3p hsa-miR-30d hsa-miR-410 hsa-miR-188-3p hsa-miR-144 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidGLDC 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for GLDC
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GLDC
    Clone
    Products:
         
    OriGene clones in human, mouse for GLDC (see all 5)
    OriGene ORF clones in mouse, rat for GLDC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GLDC (NM_000170)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GLDC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GLDC
    Sirion Biotech Customized lentivirus for stable overexpression of GLDC 
                         Customized lentivirus expression plasmids for stable overexpression of GLDC 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for GLDC
    OriGene qSTAR qPCR primer pairs in human, mouse for GLDC
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GLDC
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GLDC
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GLDC

    Additional mRNA sequence: 

    AK308470.1 AK310534.1 AK314156.1 BC111993.1 BC111995.1 D90239.1 M63635.1 M64590.1 

    9 DOTS entries:

    DT.213965  DT.95357371  DT.121229099  DT.121194184  DT.75176923  DT.97808198  DT.95163593  DT.101973864 
    DT.40105780 

    24/107 AceView cDNA sequences (see all 107):

    AV654845 AV659118 CB161786 AW593954 BG675043 F05755 BF685886 AU124921 
    AI625793 BX094481 AI632186 AW241569 R94124 BM556699 AU130455 BI006823 
    M64590 H11815 BE542432 AV659182 BF061978 AU125752 BG257593 BX103225 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GLDC expression in normal human tissues (normalized intensities)      GLDC embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGACTGTGC
    GLDC Expression
    About this image


    GLDC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/14 selected tissues (see all 14) fully expand
     
     Brain (Nervous System)    fully expand to see all 22 entries
             Thalamus
             Fetal Neuronal Stem Cells (NSC)   
             Substantia Nigra   
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 12 entries
             hIPS1
             ESI-017   
     
     Kidney (Urinary System)    fully expand to see all 5 entries
             Metanephros
             Human Renal Mesangial Cells (HRMC)   
     
     Epithelium (Uncategorized)    fully expand to see all 3 entries
             Human Renal Proximal Tubular Epithelial Cells (HRPTEpiC)   
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Retina
             Human Lens Epithelial Cells (HLEpiC)   

    See GLDC Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GLDC

    SOURCE GeneReport for Unigene cluster: Hs.584238
        SABiosciences Expression via Pathway-Focused PCR Array including GLDC: 
              Amino Acid Metabolism II in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for GLDC
    OriGene qSTAR qPCR primer pairs in human, mouse for GLDC
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GLDC
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GLDC
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GLDC
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GLDC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for GLDC gene from 10/28 species (see all 28)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gldc1 , 5 glycine decarboxylase1, 5 86.8(n)1
    92.45(a)1
      19 (24.87 cM)5
    1041741  NM_138595.11  NP_613061.11 
     300984495 
    chicken
    (Gallus gallus)
    Aves GLDC1 glycine dehydrogenase (decarboxylating) 76.83(n)
    83.47(a)
      374222  NM_204322.1  NP_989653.1 
    lizard
    (Anolis carolinensis)
    Reptilia GLDC6
    Uncharacterized protein
    83(a)
    1 ↔ 1
    2(52713459-52765499)
    African clawed frog
    (Xenopus laevis)
    Amphibia gldc-prov2 glycine dehydrogenase (decarboxylating; glycine decarboxylase, more 77.37(n)    BC042245.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb23b052 wufb23b05 77.25(n)   321621  BC057478.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG39991 , 3 glycine dehydrogenase
    (decarboxylating)3
    CG39991
    64(a)3
    61.83(n)1
    64.56(a)1
      86A23
    412531  NM_141732.11  NP_649989.11 
    worm
    (Caenorhabditis elegans)
    Secernentea R12C12.11 Protein R12C12.1 59.07(n)
    59(a)
      174012  NM_062808.4  NP_495209.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GCV2(YMR189W)4
    GCV21
    P subunit of the mitochondrial glycine decarboxylase more4
    Gcv2p1
    55.32(n)1
    54.75(a)1
      13(637500-640604)4
    8552271, 4  NP_013914.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons GLDP21 glycine dehydrogenase [decarboxylating] 1 59.39(n)
    57.61(a)
      817149  NM_128167.3  NP_180178.1 
    rice
    (Oryza sativa)
    Liliopsida Os.266422 Oryza sativa (japonica cultivar-group) glycine dehydrogenase more 74.47(n)    AY346327.1 


    ENSEMBL Gene Tree for GLDC (if available)
    TreeFam Gene Tree for GLDC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GLDC gene

    GLDC for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for GLDC
    PGOHUM00000245917


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3600 SNPs in GLDC are shown (see all 3600)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0168494
    Non-ketotic hyperglycinemia (NKH)4--see VAR_0168492 A P mis40--------
    VAR_0049794
    Non-ketotic hyperglycinemia (NKH)4--see VAR_0049792 S I mis40--------
    rs1219649761,2,4
    C,FNon-ketotic hyperglycinemia (NKH)4 pathogenic16585992(-) AAGAGA/C/GACCAG 2 S R mis12NA EU 5870
    rs1219649771,2
    Cpathogenic16550183(-) CAGTGC/TGGCCC 2 A V mis10--------
    rs1219649801,2
    Cpathogenic16551531(-) CTGTCA/GCCCTG 2 H R mis10--------
    rs1219649741,2
    Cpathogenic16585179(-) GAACAG/TTTCGT 2 S I mis11Minor allele frequency- T:0.00NA 4550
    rs1219649791,2
    Cpathogenic16591871(-) CTTGGC/TGAATA 2 A V mis10--------
    VAR_0168504
    ----see VAR_0168502 P T mis40--------
    rs1479392691,2
    C--6528812(+) GCCACC/TGCGCC 1 -- ds50010--------
    rs1401687831,2
    --6528814(+) CACCGC/TGCCTG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for GLDC (6532464 - 6645692 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/15 variations for GLDC (see all 15):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv416560CNV Insertion16902084
    nsv892164CNV Loss21882294
    nsv521556CNV Loss19592680
    nsv892166CNV Loss21882294
    dgv8023n71CNV Loss21882294
    nsv831498CNV Loss17160897
    dgv8022n71CNV Loss21882294
    nsv519777CNV Gain19592680
    esv2752308CNV Gain17911159
    nsv831497CNV Gain17160897


    Human Gene Mutation Database (HGMD): GLDC
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing GLDC
    DNA2.0 Custom Variant and Variant Library Synthesis for GLDC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 238300   
    OMIM disorders: 605899  
    UniProtKB/Swiss-Prot: GCSP_HUMAN, P23378
  • Non-ketotic hyperglycinemia (NKH) [MIM:605899]: Autosomal recessive disease characterized by accumulation
    of a large amount of glycine in body fluid and by severe neurological symptoms. Note=The disease is caused by
    mutations affecting the gene represented in this entry

  • 7 diseases for GLDC:    About MalaCards
    gldc-related glycine encephalopathy    glycine encephalopathy    early myoclonic encephalopathy    autosomal recessive disease
    neural tube defects    tuberculosis    mental retardation

    2 diseases from the University of Copenhagen DISEASES database for GLDC:
    Glycine encephalopathy     Early myoclonic encephalopathy

    GLDC for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for GLDC gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hyperglycinemia nonketotic 95.5 12 10798358 (2), 15851735 (2), 16601880 (1), 2268343 (1) (see all 10)
    hyperglycinemia 94.9 5 1943691 (1), 12402263 (1), 15824356 (1), 18581728 (1)
    mental retardation 15.9 2 15824356 (1)
    tuberculosis 6.07 1 7698116 (1)
    shock 0 1 15295627 (1)

    GeneTests: GLDC
    GeneReviews: GLDC
    Genetic Association Database (GAD): GLDC
    Human Genome Epidemiology (HuGE) Navigator: GLDC (4 documents)

    Export disorders for GLDC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GLDC gene, integrated from 9 sources (see all 72):
    (articles sorted by number of sources associating them with GLDC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The glycine cleavage system. Molecular cloning of the chicken and human glycine decarboxylase cDNAs and some characteristics involved in the deduced protein structures. (PubMed id 1993704)1, 2, 3, 9 Kume A.... Hiraga K. (1991)
    2. Structural and expression analyses of normal and mutant mRNA encoding glycine decarboxylase: three-base deletion in mRNA causes nonketotic hyperglycinemia. (PubMed id 1996985)1, 2, 3, 9 Kure S....Tada K. (1991)
    3. Comprehensive mutation analysis of GLDC, AMT, and GCSH in nonketotic hyperglycinemia. (PubMed id 16450403)1, 4, 9 Kure S....Matsubara Y. (2006)
    4. Genomic deletion within GLDC is a major cause of non-ketotic hyperglycinaemia. (PubMed id 17361008)1, 7, 9 Kanno J....Kure S. (2007)
    5. Recurrent mutations in P- and T-proteins of the glycine cleavage complex and a novel T-protein mutation (N145I): a strategy for the molecular investigation of patients with nonketotic hyperglycinemia (NKH). (PubMed id 11286506)1, 2, 9 Toone J.R.... James E.R. (2001)
    6. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    7. Nonketotic hyperglycinemia (glycine encephalopathy): laboratory diagnosis. (PubMed id 11592811)1, 2 Applegarth D.A. and Toone J.R. (2001)
    8. Identification of a common mutation in Finnish patients with nonketotic hyperglycinemia. (PubMed id 1634607)1, 2 Kure S.... Leisti J. (1992)
    9. Human glycine decarboxylase gene (GLDC) and its highly conserved processed pseudogene (psiGLDC): their structure and expression, and the identification of a large deletion in a family with nonketotic hyperglycinemia. (PubMed id 10798358)1, 9 Takayanagi M....Narisawa K. (2000)
    10. Mild glycine encephalopathy (NKH) in a large kindred due to a silent exonic GLDC splice mutation. (PubMed id 15851735)1, 9 Flusser H....Kure S. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2731 HGNC: 4313 AceView: GLDC Ensembl:ENSG00000178445 euGenes: HUgn2731
    ECgene: GLDC Kegg: 2731 H-InvDB: GLDC

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GLDC Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/GLDC

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GLDC gene:
    Search GeneIP for patents involving GLDC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for GLDC   OriGene RNAi products in human, mouse, rat for GLDC  
     OriGene qPCR primer pairs and template standards for GLDC   OriGene Protein Over-expression Lysate for GLDC  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for GLDC  
     OriGene qSTAR qPCR primer pairs in human, mouse for GLDC   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for GLDC   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for GLDC   OriGene Custom Protein Services for GLDC  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GLDC
     QIAGEN SeqTarget long-range PCR primers for resequencing GLDC
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GLDC
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GLDC
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GLDC
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GLDC
     GenScript Custom Purified and Recombinant Proteins Services for GLDC GenScript cDNA clones with any tag delivered in your preferred vector for GLDC
     GenScript Custom Assay Services for GLDC GenScript Custom Superior Antibodies Services for GLDC
     GenScript Custom overexpressing Cell Line Services for GLDC CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for GLDC 

     Regulatory tfbs in GLDC promoter
     Search Chromatin IP Primers for GLDC
     RT2 qPCR Primer Assay in human, mouse, rat GLDC
     Search GNC Networks for GLDC
     SABiosciences PCR Arrays including human, mouse, rat GLDC
     Search Tocris compounds for GLDC (GCSP)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     GLDC antibodies
     GLDC proteins
     Antibodies for GLDC
     See all of Abcam's Antibodies, Kits and Proteins for GLDC
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for GLDC
     Antibodies for GLDC
     ELISAs for GLDC
     CLIAs for GLDC
     Search LifeMap BioReagents cell lines for GLDC
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GLDC
     SwitchGear 3'UTR luciferase reporter plasmids for GLDC
     SwitchGear Promoter luciferase reporter plasmids for GLDC
     ThermoFisher Antibody for GLDC
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GLDC
     inGenious Targeting Laboratory - Custom generated mouse model solutions for GLDC
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GLDC
    Customized:
     lentivirus for stable overexpression of GLDC
     lentivirus expression plasmids for stable overexpression of GLDC
     adenovirus for overexpression of GLDC
     LSBio Antibodies in human, mouse, rat for GLDC
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      GLDC gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4