Aliases for GLDC Gene
- Glycine Decarboxylase 2 3 4 5
- Glycine Dehydrogenase (Aminomethyl-Transferring) 3 4
- Glycine Cleavage System Protein P 2 3
- EC 188.8.131.52 4 58
- GCSP 3 4
- Glycine Dehydrogenase (Decarboxylating; Glycine Decarboxylase, Glycine Cleavage System Protein P) 2
- Glycine Dehydrogenase (Decarboxylating), Mitochondrial 3
- Glycine Dehydrogenase [Decarboxylating], Mitochondrial 3
External Ids for GLDC Gene
Previous GeneCards Identifiers for GLDC Gene
Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the P protein, which binds to glycine and enables the methylamine group from glycine to be transferred to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH).[provided by RefSeq, Jan 2010]
GeneCards Summary for GLDC Gene
GLDC (Glycine Decarboxylase) is a Protein Coding gene. Diseases associated with GLDC include Glycine Encephalopathy and D-Glycericacidemia. Among its related pathways are Metabolism and Glyoxylate metabolism and glycine degradation. GO annotations related to this gene include electron carrier activity and lyase activity.
UniProtKB/Swiss-Prot for GLDC Gene
The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH).