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Aliases for GLCE Gene

Aliases for GLCE Gene

  • Glucuronic Acid Epimerase 2 3
  • Heparin/Heparan Sulfate:Glucuronic Acid C5-Epimerase 3 4
  • Heparosan-N-Sulfate-Glucuronate 5-Epimerase 3 4
  • UDP-Glucuronic Acid Epimerase 2 3
  • Heparan Sulfate C5-Epimerase 3 4
  • Heparan Sulfate Epimerase 2 3
  • HSEPI 3 4
  • Heparin/Heparan Sulfate-Glucuronic Acid C5-Epimerase 3
  • D-Glucuronyl C5-Epimerase 2
  • Glucuronyl C5-Epimerase 3
  • EC 5.1.3.17 4
  • KIAA0836 4
  • EC 5.1.3 63

External Ids for GLCE Gene

Previous GeneCards Identifiers for GLCE Gene

  • GC15P065389
  • GC15P062646
  • GC15P067127
  • GC15P067168
  • GC15P067240
  • GC15P069452
  • GC15P046285

Summaries for GLCE Gene

Entrez Gene Summary for GLCE Gene

  • Heparan sulfate (HS) is a negatively charged cell surface polysaccharide required for the biologic activities of circulating extracellular ligands. GLCE is responsible for epimerization of D-glucuronic acid (GlcA) to L-iduronic acid (IdoA) of HS, which endows the nascent polysaccharide chain with the ability to bind growth factors and cytokines (Ghiselli and Agrawal, 2005 [PubMed 15853773]).[supplied by OMIM, Jun 2008]

GeneCards Summary for GLCE Gene

GLCE (Glucuronic Acid Epimerase) is a Protein Coding gene. Among its related pathways are Metabolism and Glycosaminoglycan metabolism. GO annotations related to this gene include racemase and epimerase activity, acting on carbohydrates and derivatives and UDP-glucuronate 5-epimerase activity.

UniProtKB/Swiss-Prot for GLCE Gene

  • Converts D-glucuronic acid residues adjacent to N-sulfate sugar residues to L-iduronic acid residues, both in maturing heparan sulfate (HS) and heparin chains. This is important for further modifications that determine the specificity of interactions between these glycosaminoglycans and proteins.

Gene Wiki entry for GLCE Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLCE Gene

Genomics for GLCE Gene

Regulatory Elements for GLCE Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GLCE Gene

Chromosome:
15
Start:
69,160,560 bp from pter
End:
69,272,217 bp from pter
Size:
111,658 bases
Orientation:
Plus strand

Genomic View for GLCE Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GLCE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLCE Gene

Proteins for GLCE Gene

  • Protein details for GLCE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94923-GLCE_HUMAN
    Recommended name:
    D-glucuronyl C5-epimerase
    Protein Accession:
    O94923
    Secondary Accessions:
    • Q6GUQ2

    Protein attributes for GLCE Gene

    Size:
    617 amino acids
    Molecular mass:
    70101 Da
    Quaternary structure:
    • Interacts with HS2ST1.

neXtProt entry for GLCE Gene

Proteomics data for GLCE Gene at MOPED

Selected DME Specific Peptides for GLCE Gene

Post-translational modifications for GLCE Gene

  • Ubiquitination at Lys 98
  • Glycosylation at Ser 44, Ser 59, and Asn 225
  • Modification sites at PhosphoSitePlus

Other Protein References for GLCE Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for GLCE Gene

Protein Domains for GLCE Gene

Suggested Antigen Peptide Sequences for GLCE Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O94923

UniProtKB/Swiss-Prot:

GLCE_HUMAN :
  • Belongs to the D-glucuronyl C5-epimerase family.
Family:
  • Belongs to the D-glucuronyl C5-epimerase family.
genes like me logo Genes that share domains with GLCE: view

No data available for Gene Families for GLCE Gene

Function for GLCE Gene

Molecular function for GLCE Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Heparosan-N-sulfate D-glucuronate = heparosan-N-sulfate L-iduronate.
UniProtKB/Swiss-Prot Function:
Converts D-glucuronic acid residues adjacent to N-sulfate sugar residues to L-iduronic acid residues, both in maturing heparan sulfate (HS) and heparin chains. This is important for further modifications that determine the specificity of interactions between these glycosaminoglycans and proteins.

Enzyme Numbers (IUBMB) for GLCE Gene

Gene Ontology (GO) - Molecular Function for GLCE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives ISS --
GO:0047464 heparosan-N-sulfate-glucuronate 5-epimerase activity IMP 20118238
GO:0050379 UDP-glucuronate 5-epimerase activity IDA 15853773
genes like me logo Genes that share ontologies with GLCE: view
genes like me logo Genes that share phenotypes with GLCE: view

Animal Models for GLCE Gene

MGI Knock Outs for GLCE:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GLCE

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for GLCE Gene

Localization for GLCE Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLCE Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GLCE Gene COMPARTMENTS Subcellular localization image for GLCE gene
Compartment Confidence
golgi apparatus 4
mitochondrion 2

Gene Ontology (GO) - Cellular Components for GLCE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005794 Golgi apparatus ISS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GLCE: view

Pathways & Interactions for GLCE Gene

genes like me logo Genes that share pathways with GLCE: view

UniProtKB/Swiss-Prot O94923-GLCE_HUMAN

  • Pathway: Glycan metabolism; heparan sulfate biosynthesis
  • Pathway: Glycan metabolism; heparin biosynthesis

Interacting Proteins for GLCE Gene

Gene Ontology (GO) - Biological Process for GLCE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0006024 glycosaminoglycan biosynthetic process TAS --
GO:0015012 heparan sulfate proteoglycan biosynthetic process ISS --
GO:0030203 glycosaminoglycan metabolic process TAS --
GO:0030210 heparin biosynthetic process ISS --
genes like me logo Genes that share ontologies with GLCE: view

No data available for SIGNOR curated interactions for GLCE Gene

Drugs & Compounds for GLCE Gene

(4) Drugs for GLCE Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Heparin Approved, Investigational Pharma Antagonist 672,226
Iduronic acid Experimental Pharma 0
D-Glucuronic acid Experimental Pharma 0
Chondroitin Nutra 40

(6) Additional Compounds for GLCE Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
D-Glucurono-6,3-lactone
  • D-Glucurone
  • D-Glucuronic acid
  • D-Glucuronic acid lactone (van)
  • D-Glucurono-3,6-lactone
  • D-Glucuronolactone
32449-92-6
Chondroitin sulfate
  • Chondritinsulfate
  • Chondritinsulphate
  • Chondroitin 6-sulfate
  • Chondroitin 6-sulphate
  • Chondroitin polysulfate
9007-28-7
DERMATAN SULFATE
glucuronic acid
heparan sulfate
  • alpha-Idosane
  • Heparan N-sulfate
  • Heparan N-sulphate
  • Heparan sulfate
  • Heparan sulphate
9050-30-0
genes like me logo Genes that share compounds with GLCE: view

Transcripts for GLCE Gene

Unigene Clusters for GLCE Gene

Glucuronic acid epimerase:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GLCE

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GLCE Gene

No ASD Table

Relevant External Links for GLCE Gene

GeneLoc Exon Structure for
GLCE
ECgene alternative splicing isoforms for
GLCE

Expression for GLCE Gene

mRNA expression in normal human tissues for GLCE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GLCE Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x7.1) and Brain - Cerebellum (x6.5).

Protein differential expression in normal tissues from HIPED for GLCE Gene

This gene is overexpressed in Peripheral blood mononuclear cells (29.7), Pancreatic juice (17.5), and Placenta (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GLCE Gene



SOURCE GeneReport for Unigene cluster for GLCE Gene Hs.183006

genes like me logo Genes that share expression patterns with GLCE: view

Protein tissue co-expression partners for GLCE Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for GLCE Gene

Orthologs for GLCE Gene

This gene was present in the common ancestor of animals.

Orthologs for GLCE Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GLCE 35
  • 93.94 (n)
  • 97.24 (a)
GLCE 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GLCE 35
  • 93.83 (n)
  • 97.56 (a)
GLCE 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Glce 35
  • 91.46 (n)
  • 95.95 (a)
Glce 16
Glce 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GLCE 35
  • 99.89 (n)
  • 99.84 (a)
GLCE 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Glce 35
  • 91.46 (n)
  • 96.11 (a)
oppossum
(Monodelphis domestica)
Mammalia GLCE 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GLCE 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves GLCE 35
  • 75 (n)
  • 86.92 (a)
GLCE 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GLCE 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia glce 35
  • 70.68 (n)
  • 76.9 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.32770 35
zebrafish
(Danio rerio)
Actinopterygii glceb 35
  • 69.17 (n)
  • 77.09 (a)
glcea 36
  • 71 (a)
OneToMany
glceb 36
  • 77 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005699 35
  • 54.1 (n)
  • 52.78 (a)
fruit fly
(Drosophila melanogaster)
Insecta Hsepi 35
  • 53.06 (n)
  • 49.51 (a)
Hsepi 36
  • 41 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea hse-5 35
  • 49.4 (n)
  • 43.4 (a)
hse-5 36
  • 37 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2697 36
  • 47 (a)
OneToOne
Species with no ortholog for GLCE:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GLCE Gene

ENSEMBL:
Gene Tree for GLCE (if available)
TreeFam:
Gene Tree for GLCE (if available)

Paralogs for GLCE Gene

No data available for Paralogs for GLCE Gene

Variants for GLCE Gene

Sequence variations from dbSNP and Humsavar for GLCE Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs962036 -- 69,203,026(+) GGATG(A/G)TACTA intron-variant
rs982379 -- 69,253,807(+) tagta(A/G)caagt intron-variant
rs994359 -- 69,159,051(+) cccat(C/G)tcagc upstream-variant-2KB
rs1112646 -- 69,177,924(-) TGCAA(A/C)AACAG intron-variant
rs1249167 -- 69,182,875(-) accac(A/G)cccga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GLCE Gene

Variant ID Type Subtype PubMed ID
nsv517185 CNV Gain+Loss 19592680
nsv904328 CNV Loss 21882294
esv2476720 CNV Deletion 19546169
esv23604 CNV Gain 19812545
esv2749821 CNV Deletion 23290073
esv2264721 CNV Deletion 18987734
esv2741191 CNV Deletion 23290073
dgv343e201 CNV Deletion 23290073
esv2749822 CNV Deletion 23290073
esv2749824 CNV Deletion 23290073
esv989223 OTHER Inversion 20482838

Variation tolerance for GLCE Gene

Residual Variation Intolerance Score: 19.86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.29; 41.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GLCE Gene

HapMap Linkage Disequilibrium report
GLCE

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLCE Gene

Disorders for GLCE Gene

Relevant External Links for GLCE

Genetic Association Database (GAD)
GLCE
Human Genome Epidemiology (HuGE) Navigator
GLCE
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GLCE
genes like me logo Genes that share disorders with GLCE: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GLCE Gene

Publications for GLCE Gene

  1. The human D-glucuronyl C5-epimerase gene is transcriptionally activated through the beta-catenin-TCF4 pathway. (PMID: 15853773) Ghiselli G. … Agrawal A. (Biochem. J. 2005) 2 23 67
  2. Decreased expression of human D-glucuronyl C5-epimerase in breast cancer. (PMID: 17985344) Grigorieva E. … Sidorov S.V. (Int. J. Cancer 2008) 23 67
  3. Hydrogen peroxide as a potential mediator of the transcriptional regulation of heparan sulphate biosynthesis in keratinocytes. (PMID: 18463796) Nakayama F. … Akashi M. (Cell. Mol. Biol. Lett. 2008) 23 67
  4. Expression of different proteoglycans in human breast tumors. (PMID: 17922662) Eshchenko T.Y. … Grigorieva E.V. (Biochemistry Mosc. 2007) 23 67
  5. The formation of extracellular matrix during chondrogenic differentiation of mesenchymal stem cells correlates with increased levels of xylosyltransferase I. (PMID: 16778156) Prante C. … GAPtting C. (Stem Cells 2006) 23 67

Products for GLCE Gene

Sources for GLCE Gene

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