Aliases for GLCE Gene
External Ids for GLCE Gene
Previous GeneCards Identifiers for GLCE Gene
Heparan sulfate (HS) is a negatively charged cell surface polysaccharide required for the biologic activities of circulating extracellular ligands. GLCE is responsible for epimerization of D-glucuronic acid (GlcA) to L-iduronic acid (IdoA) of HS, which endows the nascent polysaccharide chain with the ability to bind growth factors and cytokines (Ghiselli and Agrawal, 2005 [PubMed 15853773]).[supplied by OMIM, Jun 2008]
GeneCards Summary for GLCE Gene
GLCE (Glucuronic Acid Epimerase) is a Protein Coding gene. Among its related pathways are Metabolism and Glycosaminoglycan metabolism. GO annotations related to this gene include racemase and epimerase activity, acting on carbohydrates and derivatives and UDP-glucuronate 5-epimerase activity.
UniProtKB/Swiss-Prot for GLCE Gene
Converts D-glucuronic acid residues adjacent to N-sulfate sugar residues to L-iduronic acid residues, both in maturing heparan sulfate (HS) and heparin chains. This is important for further modifications that determine the specificity of interactions between these glycosaminoglycans and proteins.