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Aliases for GLCCI1 Gene

Aliases for GLCCI1 Gene

  • Glucocorticoid Induced 1 2 3 5
  • Glucocorticoid Induced Transcript 1 2 3
  • FAM117C 3
  • GIG18 3
  • TSSN1 3
  • GCTR 3

External Ids for GLCCI1 Gene

Previous GeneCards Identifiers for GLCCI1 Gene

  • GC07P007653
  • GC07P007423
  • GC07P007752
  • GC07P007781

Summaries for GLCCI1 Gene

Entrez Gene Summary for GLCCI1 Gene

  • This gene encodes a protein of unknown function. Expression of this gene is induced by glucocorticoids and may be an early marker for glucocorticoid-induced apoptosis. Single nucleotide polymorphisms in this gene are associated with a decreased response to inhaled glucocorticoids in asthmatic patients. [provided by RefSeq, Feb 2012]

GeneCards Summary for GLCCI1 Gene

GLCCI1 (Glucocorticoid Induced 1) is a Protein Coding gene. Diseases associated with GLCCI1 include glucocorticoid therapy, response to and bacterial meningitis. An important paralog of this gene is FAM117A.

Gene Wiki entry for GLCCI1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLCCI1 Gene

Genomics for GLCCI1 Gene

Regulatory Elements for GLCCI1 Gene

Promoters for GLCCI1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GLCCI1 on UCSC Golden Path with GeneCards custom track

Genomic Location for GLCCI1 Gene

Chromosome:
7
Start:
7,968,743 bp from pter
End:
8,094,272 bp from pter
Size:
125,530 bases
Orientation:
Plus strand

Genomic View for GLCCI1 Gene

Genes around GLCCI1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GLCCI1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GLCCI1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLCCI1 Gene

Proteins for GLCCI1 Gene

  • Protein details for GLCCI1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VQ1-GLCI1_HUMAN
    Recommended name:
    Glucocorticoid-induced transcript 1 protein
    Protein Accession:
    Q86VQ1
    Secondary Accessions:
    • A4D103
    • Q96FD0

    Protein attributes for GLCCI1 Gene

    Size:
    547 amino acids
    Molecular mass:
    58024 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GLCCI1 Gene

Proteomics data for GLCCI1 Gene at MOPED

Post-translational modifications for GLCCI1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GLCCI1 Gene

No data available for DME Specific Peptides for GLCCI1 Gene

Domains & Families for GLCCI1 Gene

Protein Domains for GLCCI1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GLCCI1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GLCCI1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for GLCCI1 Gene

Function for GLCCI1 Gene

genes like me logo Genes that share phenotypes with GLCCI1: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GLCCI1 Gene

Localization for GLCCI1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GLCCI1 Gene COMPARTMENTS Subcellular localization image for GLCCI1 gene
Compartment Confidence
nucleus 4
cytosol 2
golgi apparatus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GLCCI1 Gene

Pathways & Interactions for GLCCI1 Gene

SuperPathways for GLCCI1 Gene

No Data Available

Interacting Proteins for GLCCI1 Gene

Gene Ontology (GO) - Biological Process for GLCCI1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GLCCI1 Gene

Drugs & Compounds for GLCCI1 Gene

(6) Drugs for GLCCI1 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Budesonide Approved Pharma Anti-inflammatory corticosteroid 381
Flunisolide Approved, Investigational Pharma 6
Fluticasone propionate Approved Pharma Selective high affinity glucocorticoid receptor agonist 0
Nedocromil Approved Pharma 5
Triamcinolone Approved Pharma Agonist 448
genes like me logo Genes that share compounds with GLCCI1: view

Transcripts for GLCCI1 Gene

Unigene Clusters for GLCCI1 Gene

Glucocorticoid induced transcript 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GLCCI1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b
SP1: - - - - - - -
SP2: -
SP3: -
SP4: -
SP5: - - -
SP6:
SP7:

Relevant External Links for GLCCI1 Gene

GeneLoc Exon Structure for
GLCCI1
ECgene alternative splicing isoforms for
GLCCI1

Expression for GLCCI1 Gene

mRNA expression in normal human tissues for GLCCI1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GLCCI1 Gene

This gene is overexpressed in Pancreatic juice (32.2), Peripheral blood mononuclear cells (9.1), Frontal cortex (8.2), and CD8 Tcells (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GLCCI1 Gene



SOURCE GeneReport for Unigene cluster for GLCCI1 Gene Hs.131673

mRNA Expression by UniProt/SwissProt for GLCCI1 Gene

Q86VQ1-GLCI1_HUMAN
Tissue specificity: Predominantly expressed in lung, spleen, thymus and testis and, at lower levels, in brain, bone marrow, peripheral leukocytes, skin and trachea.
genes like me logo Genes that share expression patterns with GLCCI1: view

Protein tissue co-expression partners for GLCCI1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for GLCCI1 Gene

Orthologs for GLCCI1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GLCCI1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GLCCI1 35
  • 91.73 (n)
  • 96.96 (a)
GLCCI1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GLCCI1 35
  • 93.19 (n)
  • 94.95 (a)
GLCCI1 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Glcci1 35
  • 89.37 (n)
  • 91.98 (a)
Glcci1 16
Glcci1 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GLCCI1 35
  • 98.53 (n)
  • 98.17 (a)
GLCCI1 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Glcci1 35
  • 91.03 (n)
  • 95.94 (a)
oppossum
(Monodelphis domestica)
Mammalia GLCCI1 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves GLCCI1 35
  • 81.01 (n)
  • 82.6 (a)
GLCCI1 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GLCCI1 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia glcci1 35
  • 70.44 (n)
  • 70.59 (a)
zebrafish
(Danio rerio)
Actinopterygii glcci1 35
  • 66.09 (n)
  • 66.58 (a)
glcci1 36
  • 50 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5186 36
  • 28 (a)
OneToMany
Species with no ortholog for GLCCI1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GLCCI1 Gene

ENSEMBL:
Gene Tree for GLCCI1 (if available)
TreeFam:
Gene Tree for GLCCI1 (if available)

Paralogs for GLCCI1 Gene

Paralogs for GLCCI1 Gene

(2) SIMAP similar genes for GLCCI1 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with GLCCI1: view

Variants for GLCCI1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for GLCCI1 Gene

Q86VQ1-GLCI1_HUMAN
Polymorphisms dbSNP:rs37972 and dbSNP:rs37973, located in GLCCI1 promoter region, are associated with a decreased response to glucorticoid treatment [MIM:614400] in asthma patients (PubMed:21991891), as well as in chronic obstructive pulmonary disease patients (PubMed:22187997). The mean increase in forced expiratory volume in 1 second in glucorticoid treated subjects who are homozygous for the mutant (G) rs37973 allele is only about one-third of that seen in similarly treated subjects who are homozygous for the wild-type allele (A) (PubMed:21991891). These polymorphisms affect GLCCI1 transcription level.

Sequence variations from dbSNP and Humsavar for GLCCI1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs37974 -- 7,970,755(+) TAGCC(A/G)AAACA intron-variant
rs37975 -- 7,973,864(+) TTTAA(G/T)TCATT intron-variant
rs37990 -- 7,987,543(+) TAACA(A/C/T)ATTGC intron-variant
rs37991 -- 7,987,838(+) TCCGC(C/T)TTGGC intron-variant
rs37992 -- 7,988,131(+) CCCCA(A/G)ATCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GLCCI1 Gene

Variant ID Type Subtype PubMed ID
esv2752177 CNV Gain 17911159
esv267604 CNV Insertion 20981092
esv273994 CNV Insertion 20981092
esv271406 CNV Insertion 20981092
nsv5633 CNV Insertion 18451855
nsv518779 CNV Loss 19592680
nsv519058 CNV Loss 19592680
esv1009766 CNV Deletion 20482838
esv2659380 CNV Deletion 23128226

Variation tolerance for GLCCI1 Gene

Residual Variation Intolerance Score: 15.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.80; 33.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GLCCI1 Gene

HapMap Linkage Disequilibrium report
GLCCI1
Human Gene Mutation Database (HGMD)
GLCCI1

Disorders for GLCCI1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for GLCCI1 Gene - From: OMIM, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
glucocorticoid therapy, response to
bacterial meningitis
  • meningitis, bacterial
asthma
  • asthma, protection against
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for GLCCI1

Genetic Association Database (GAD)
GLCCI1
Human Genome Epidemiology (HuGE) Navigator
GLCCI1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GLCCI1
genes like me logo Genes that share disorders with GLCCI1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GLCCI1 Gene

Publications for GLCCI1 Gene

  1. Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma. (PMID: 21991891) Tantisira K.G. … Weiss S.T. (N. Engl. J. Med. 2011) 3 4 67
  2. GLCCI1 and Glucocorticoid Receptor Genetic Diversity and Response to Glucocorticoid-Based Treatment of Graft-versus-Host Disease. (PMID: 25843653) O'Meara A. … Tamouza R. (Biol. Blood Marrow Transplant. 2015) 3
  3. GLCCI1 rs37973 does not influence treatment response to inhaled corticosteroids in white subjects with asthma. (PMID: 24131825) Hosking L. … Meyers D. (J. Allergy Clin. Immunol. 2014) 3
  4. GLCCI1 variant accelerates pulmonary function decline in patients with asthma receiving inhaled corticosteroids. (PMID: 24673601) Izuhara Y. … Mishima M. (Allergy 2014) 3
  5. Heritability and genetic association analysis of cognition in theA Diabetes Heart Study. (PMID: 24684796) Cox A.J. … Bowden D.W. (Neurobiol. Aging 2014) 3

Products for GLCCI1 Gene

Sources for GLCCI1 Gene

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