GLB1L3 Gene
protein-coding GIFtS: 43
GCID: GC11P134145
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|
galactosidase, beta 1-like 3
| |
Aliases
for GLB1L3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Galactosidase, Beta 1-Like 31 2 | | EC 3.2.1.-3 | | FLJ902311 | | EC 3.2.18 | | Beta-Galactosidase-1-Like Protein 32 | | EC 3.2.1.238 | | Galactosidase, Beta 1 Like 32 | | |
Export aliases for GLB1L3 gene to outside databasesPrevious GC identifers: GC11P133652 GC11P130101 |
Summaries
for GLB1L3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for GLB1L3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_033899.8
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the GLB1L3 gene promoter:
CREB AML1a deltaCREB SEF-1 (1) POU6F1 (c2) POU3F2 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for GLB1L3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GLB1L3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q25 Ensembl cytogenetic band: 11q25 HGNC cytogenetic band: 11q25GLB1L3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P134145: view genomic region
(about GC identifiers)
Start:
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134,144,139 bp from pter |
End:
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134,189,458 bp from pter |
Size:
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45,320 bases |
Orientation:
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plus strand |
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Proteins
for GLB1L3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: GLBL3_HUMAN, Q8NCI6 (See
protein sequence)Recommended Name: Beta-galactosidase-1-like protein 3 Size: 653 amino acids; 74823 Da
Secondary accessions: A6NEM0 A6NN15 Q6P3S3 Q96FF8Alternative splicing: 3 isoforms: Q8NCI6-1 Q8NCI6-2 Q8NCI6-4 Explore the universe of human proteins at neXtProt for GLB1L3: NX_Q8NCI6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8NCI6
4/5 DME Specific Peptides for GLB1L3 (Q8NCI6) (see all 5)
GLB1L3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001073876.2
ENSEMBL proteins: ENSP00000374537 ENSP00000396615 ENSP00000397929
Human Recombinant Protein Products for GLB1L3:
GLB1L3 Antibody Products:
Assay Products for GLB1L3: |
Protein
Domains /
Families
for GLB1L3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GLB1L3 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8NCI6ProtoNet protein and cluster: Q8NCI6 UniProtKB/Swiss-Prot: GLBL3_HUMAN, Q8NCI6Similarity: Belongs to the glycosyl hydrolase 35 family |
Function
for GLB1L3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Enzyme Numbers (IUBMB): EC 3.2.1.-1 EC 3.2.12 EC 3.2.1.232
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004553 | hydrolase activity, hydrolyzing O-glycosyl compounds |
-- | -- | | GO:0004565 | beta-galactosidase activity |
IEA | -- | | GO:0043169 | cation binding |
IEA | -- |
GLB1L3 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for GLB1L3:
Animal Models:
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GLB1L3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GLB1L3 |
|
Pathways & Interactions
for GLB1L3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GLB1L3
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005975 | carbohydrate metabolic process |
IEA | -- |
GLB1L3 for ontologies About GeneDecksing
|
Drugs & Compounds
for GLB1L3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for GLB1L3
Search CenterWatch for drugs/clinical trials and news about GLB1L3 / GLBL3
|
Transcripts
for GLB1L3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for GLB1L3 gene (2 alternative transcripts): NM_138416.1 NM_001080407.2 Unigene Cluster for GLB1L3: Galactosidase, beta 1-like 3 Hs.721382 [show with all ESTs]Unigene Representative Sequence: NM_0010804078 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000389887(uc010scs.2 uc010sct.2) ENST00000431683(uc009zdf.3 uc001qho.4)
ENST00000532985 ENST00000486034(uc010scu.1) ENST00000498012 ENST00000455971
ENST00000410100 ENST00000467068
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GLB1L3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GLB1L3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: GLB1L3 (NM_001080407) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GLB1L3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GLB1L3 |
Additional cDNA sequence: AK074712.1 BC011001.2 BC131702.1 7 DOTS entries: DT.101954563 DT.92053841 DT.100660936 DT.101981068 DT.95089170 DT.100727544 DT.40129379 24/145 AceView cDNA sequences (see all 145): BU173188 BC008326 BG386617 AI379142 T07976 BQ068659 BQ899101 AI262635 F11826 BM721777 BQ677578 BE382579 BM450486 BQ678746 NM_138342 BP377297 BU196788 BU168671 BQ676641 AA306370 AA035048 BF589594 BQ678539 AI805064
GeneLoc Exon Structure
|
Expression
for GLB1L3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| GLB1L3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCTGAGTGG
About this image
See GLB1L3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GLB1L3
SOURCE GeneReport for Unigene cluster: Hs.721382
SABiosciences Custom PCR Arrays for GLB1L3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GLB1L3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GLB1L3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GLB1L3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GLB1L3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GLB1L3 |
Orthologs
for GLB1L3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for GLB1L3 gene from 5/19 species (see all 19) About this table
ENSEMBL Gene Tree for GLB1L3 (if available)
TreeFam Gene Tree for GLB1L3 (if available) |
Paralogs
for GLB1L3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for GLB1L3 gene
- GLB1L2 GLB12 GLB1L22
3 SIMAP similar genes for GLB1L3 using alignment to 2 protein entries: GLBL3_HUMAN (see all proteins):GLB1L2 GLB1 GLB1L
GLB1L3 for paralogs About GeneDecksing
|
Genomic Variants
for GLB1L3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for GLB1L3 (134144139 - 134189458 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 17 variations for GLB1L3
15/17 CNVs (see all 17): 53709 75855 86096 86097 75854 48743 75856 101382 75853 86098 4764 86095 29921 48744 5280 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GLB1L3 |
|
Disorders
/ Diseases
for GLB1L3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
GLB1L3 for disorders About GeneDecksing
2  diseases for GLB1L3: About MalaCardsleber congenital amaurosis pneumonia
1 disease from the University of Copenhagen DISEASES database for GLB1L3:Leber congenital amaurosis Human Genome Epidemiology (HuGE) Navigator: GLB1L3 (1 document)
Export disorders for GLB1L3 gene to outside databases
|
Publications
for GLB1L3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for GLB1L3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with GLB1L3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)1, 2 Taylor T.D....Sakaki Y. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
|
External Searches for GLB1L3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing GLB1L3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing GLB1L3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GLB1L3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for GLB1L3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for GLB1L3 gene:
Search GeneIP for patents involving GLB1L3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for GLB1L3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GLB1L3 |
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