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Aliases for GLB1L2 Gene

Aliases for GLB1L2 Gene

  • Galactosidase Beta 1 Like 2 2 3 5
  • Beta-Galactosidase-1-Like Protein 2 3
  • Galactosidase, Beta 1-Like 2 2
  • EC 3.2.1.23 58
  • EC 3.2.1.- 4
  • EC 3.2.1 58
  • MSTP114 3
  • MST114 3

External Ids for GLB1L2 Gene

Previous GeneCards Identifiers for GLB1L2 Gene

  • GC11P133708
  • GC11P134201
  • GC11P130156

Summaries for GLB1L2 Gene

GeneCards Summary for GLB1L2 Gene

GLB1L2 (Galactosidase Beta 1 Like 2) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity, hydrolyzing O-glycosyl compounds and beta-galactosidase activity. An important paralog of this gene is GLB1L3.

Additional gene information for GLB1L2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLB1L2 Gene

Genomics for GLB1L2 Gene

Regulatory Elements for GLB1L2 Gene

Enhancers for GLB1L2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H134331 0.8 ENCODE 21.9 +0.1 78 0 HDAC1 RB1 SIN3A ZNF76 BMI1 GLIS2 HDAC8 ZNF592 TFDP1 ZNF610 GLB1L2 GC11M134366
GH11H134384 0.7 dbSUPER 16.2 +54.5 54506 3 NFIB KLF17 ZEB2 ZNF843 ZFHX2 NFIC GATA3 ZSCAN16 GLIS1 ZNF629 B3GAT1 GLB1L2 GLB1L3 GC11M134366
GH11H134332 0.5 ENCODE 22.5 -0.2 -193 0 ZNF639 NRF1 HNF4A ZFX EZH2 GLB1L2 LOC100421417
GH11H134392 0.7 dbSUPER 10.7 +65.0 65036 8 CTCF FOXA2 MAX RAD21 YY1 HIC1 POLR2A CREM BHLHE40 REST B3GAT1 GLB1L2 GLB1L3 GC11M134366
GH11H134389 0.2 dbSUPER 10.7 +59.0 59011 2 GLB1L2 B3GAT1 GLB1L3 GC11M134366
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GLB1L2 on UCSC Golden Path with GeneCards custom track

Promoters for GLB1L2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000047454 26 1001 RB1 SIN3A ZNF76 BMI1 GLIS2 HDAC8 ZNF592 TFDP1 ZNF610 SMARCA4

Genomic Location for GLB1L2 Gene

Chromosome:
11
Start:
134,331,874 bp from pter
End:
134,378,341 bp from pter
Size:
46,468 bases
Orientation:
Plus strand

Genomic View for GLB1L2 Gene

Genes around GLB1L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GLB1L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GLB1L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLB1L2 Gene

Proteins for GLB1L2 Gene

  • Protein details for GLB1L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IW92-GLBL2_HUMAN
    Recommended name:
    Beta-galactosidase-1-like protein 2
    Protein Accession:
    Q8IW92
    Secondary Accessions:
    • A6NCE6
    • Q6UX60
    • Q8NC62
    • Q8NCB3
    • Q8NCJ1
    • Q96HP3

    Protein attributes for GLB1L2 Gene

    Size:
    636 amino acids
    Molecular mass:
    72079 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAQ13636.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11149.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for GLB1L2 Gene

Selected DME Specific Peptides for GLB1L2 Gene

Q8IW92:
  • YMFHGGTNFG
  • YMFHGGTNF
  • ERGKFDFS
  • GGSIHYFRVPREYW
  • DRLLKMK
  • RGIVELLLTSD

Post-translational modifications for GLB1L2 Gene

  • Ubiquitination at posLast=165165
  • Modification sites at PhosphoSitePlus

Other Protein References for GLB1L2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for GLB1L2 Gene

Gene Families for GLB1L2 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for GLB1L2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IW92

UniProtKB/Swiss-Prot:

GLBL2_HUMAN :
  • Belongs to the glycosyl hydrolase 35 family.
Family:
  • Belongs to the glycosyl hydrolase 35 family.
genes like me logo Genes that share domains with GLB1L2: view

Function for GLB1L2 Gene

Enzyme Numbers (IUBMB) for GLB1L2 Gene

Phenotypes From GWAS Catalog for GLB1L2 Gene

Gene Ontology (GO) - Molecular Function for GLB1L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004565 beta-galactosidase activity IBA --
GO:0016787 hydrolase activity IEA --
GO:0016798 hydrolase activity, acting on glycosyl bonds IEA --
genes like me logo Genes that share ontologies with GLB1L2: view
genes like me logo Genes that share phenotypes with GLB1L2: view

Animal Models for GLB1L2 Gene

MGI Knock Outs for GLB1L2:

Animal Model Products

  • Taconic Biosciences Mouse Models for GLB1L2

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for GLB1L2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GLB1L2 Gene

Localization for GLB1L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLB1L2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GLB1L2 gene
Compartment Confidence
extracellular 4
lysosome 3
nucleus 2
endoplasmic reticulum 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for GLB1L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005773 vacuole IBA --
genes like me logo Genes that share ontologies with GLB1L2: view

Pathways & Interactions for GLB1L2 Gene

SuperPathways for GLB1L2 Gene

No Data Available

Interacting Proteins for GLB1L2 Gene

Gene Ontology (GO) - Biological Process for GLB1L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with GLB1L2: view

No data available for Pathways by source and SIGNOR curated interactions for GLB1L2 Gene

Drugs & Compounds for GLB1L2 Gene

No Compound Related Data Available

Transcripts for GLB1L2 Gene

Unigene Clusters for GLB1L2 Gene

Galactosidase, beta 1-like 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for GLB1L2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for GLB1L2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20
SP1: - -
SP2: -
SP3:

Relevant External Links for GLB1L2 Gene

GeneLoc Exon Structure for
GLB1L2
ECgene alternative splicing isoforms for
GLB1L2

Expression for GLB1L2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GLB1L2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GLB1L2 Gene

This gene is overexpressed in Colon - Sigmoid (x4.5), Uterus (x4.2), and Prostate (x4.0).

Protein differential expression in normal tissues from HIPED for GLB1L2 Gene

This gene is overexpressed in Lung (62.8) and Retina (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GLB1L2 Gene



Protein tissue co-expression partners for GLB1L2 Gene

NURSA nuclear receptor signaling pathways regulating expression of GLB1L2 Gene:

GLB1L2

SOURCE GeneReport for Unigene cluster for GLB1L2 Gene:

Hs.436178

Evidence on tissue expression from TISSUES for GLB1L2 Gene

  • Intestine(4.2)
  • Eye(2)
genes like me logo Genes that share expression patterns with GLB1L2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GLB1L2 Gene

Orthologs for GLB1L2 Gene

This gene was present in the common ancestor of animals.

Orthologs for GLB1L2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GLB1L2 33 34
  • 98.95 (n)
dog
(Canis familiaris)
Mammalia GLB1L2 33 34
  • 84.15 (n)
mouse
(Mus musculus)
Mammalia Glb1l2 33 16 34
  • 81.47 (n)
rat
(Rattus norvegicus)
Mammalia Glb1l2 33
  • 81.21 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GLB1L2 34
  • 81 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GLB1L2 33 34
  • 78.44 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 66 (a)
OneToMany
chicken
(Gallus gallus)
Aves GLB1L2 33
  • 65.35 (n)
-- 34
  • 64 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 57 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia glb1l2 33
  • 59.52 (n)
African clawed frog
(Xenopus laevis)
Amphibia loc89944-prov 33
zebrafish
(Danio rerio)
Actinopterygii si:dkey-224e22.2 33
  • 59.5 (n)
GLB1L2 34
  • 53 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Ect3 34
  • 35 (a)
ManyToMany
Gal 34
  • 32 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea T19B10.3 34
  • 31 (a)
ManyToMany
H22K11.2 34
  • 29 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13288 33
Species where no ortholog for GLB1L2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GLB1L2 Gene

ENSEMBL:
Gene Tree for GLB1L2 (if available)
TreeFam:
Gene Tree for GLB1L2 (if available)

Paralogs for GLB1L2 Gene

Paralogs for GLB1L2 Gene

(3) SIMAP similar genes for GLB1L2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GLB1L2: view

Variants for GLB1L2 Gene

Sequence variations from dbSNP and Humsavar for GLB1L2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000025628 -- 134,375,061(+) TGAGC(A/G)GTGGC utr-variant-3-prime
rs1000072890 -- 134,334,568(+) TCCAG(C/T)TGTGA intron-variant
rs1000231227 -- 134,330,686(+) CTGGT(A/G)TATTC upstream-variant-2KB
rs1000237621 -- 134,330,405(+) ATGTA(C/T)ATTTT upstream-variant-2KB
rs1000265098 -- 134,355,918(+) CATGA(A/G)GGAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GLB1L2 Gene

Variant ID Type Subtype PubMed ID
dgv1302n100 CNV loss 25217958
dgv1303n100 CNV gain+loss 25217958
dgv1304n100 CNV gain 25217958
dgv1305n100 CNV gain 25217958
dgv1306n100 CNV gain 25217958
dgv170n27 CNV gain 19166990
dgv171n27 CNV loss 19166990
dgv2204n54 CNV gain+loss 21841781
dgv2205n54 CNV loss 21841781
dgv4e196 CNV duplication 17116639
dgv59n111 CNV duplication 26073780
esv1006179 CNV insertion 20482838
esv1009565 CNV deletion 20482838
esv1324855 CNV insertion 17803354
esv1724782 CNV deletion 17803354
esv2475970 CNV deletion 19546169
esv2674216 CNV deletion 23128226
esv2745325 CNV deletion 23290073
esv2745327 CNV deletion 23290073
esv2745328 CNV deletion 23290073
esv2760555 CNV gain+loss 21179565
esv3580172 CNV gain 25503493
esv3628164 CNV loss 21293372
esv3628165 CNV gain 21293372
esv3628169 CNV gain 21293372
esv3628170 CNV gain 21293372
esv3892112 CNV gain+loss 25118596
esv3892113 CNV gain+loss 25118596
nsv1037294 CNV loss 25217958
nsv1051069 CNV gain 25217958
nsv1053071 CNV loss 25217958
nsv1110687 CNV insertion 24896259
nsv468901 CNV loss 19166990
nsv469992 CNV loss 18288195
nsv469993 CNV gain 18288195
nsv474537 CNV novel sequence insertion 20440878
nsv516459 CNV gain+loss 19592680
nsv521581 CNV gain 19592680
nsv521623 CNV gain 19592680
nsv524977 CNV loss 19592680
nsv556599 CNV loss 21841781
nsv556605 CNV gain 21841781
nsv556608 CNV gain 21841781
nsv561 CNV insertion 18451855
nsv826150 CNV gain 20364138
nsv832299 CNV loss 17160897
nsv952768 CNV deletion 24416366

Variation tolerance for GLB1L2 Gene

Residual Variation Intolerance Score: 77.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.03; 60.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GLB1L2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GLB1L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLB1L2 Gene

Disorders for GLB1L2 Gene

Relevant External Links for GLB1L2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GLB1L2

No disorders were found for GLB1L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GLB1L2 Gene

Publications for GLB1L2 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 60
  2. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 60

Products for GLB1L2 Gene

Sources for GLB1L2 Gene

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