Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GLB1L2 Gene

Aliases for GLB1L2 Gene

  • Galactosidase Beta 1 Like 2 2 3 5
  • Galactosidase, Beta 1-Like 2 2 3
  • Galactosidase Beta 1-Like 2 3
  • EC 3.2.1.23 63
  • EC 3.2.1.- 4
  • EC 3.2.1 63
  • MSTP114 3
  • MST114 3

External Ids for GLB1L2 Gene

Previous GeneCards Identifiers for GLB1L2 Gene

  • GC11P133708
  • GC11P134201
  • GC11P130156

Summaries for GLB1L2 Gene

GeneCards Summary for GLB1L2 Gene

GLB1L2 (Galactosidase Beta 1 Like 2) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity, hydrolyzing O-glycosyl compounds and beta-galactosidase activity. An important paralog of this gene is GLB1L3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLB1L2 Gene

Genomics for GLB1L2 Gene

Regulatory Elements for GLB1L2 Gene

Promoters for GLB1L2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GLB1L2 on UCSC Golden Path with GeneCards custom track

Genomic Location for GLB1L2 Gene

Chromosome:
11
Start:
134,331,874 bp from pter
End:
134,378,341 bp from pter
Size:
46,468 bases
Orientation:
Plus strand

Genomic View for GLB1L2 Gene

Genes around GLB1L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GLB1L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GLB1L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLB1L2 Gene

Proteins for GLB1L2 Gene

  • Protein details for GLB1L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IW92-GLBL2_HUMAN
    Recommended name:
    Beta-galactosidase-1-like protein 2
    Protein Accession:
    Q8IW92
    Secondary Accessions:
    • A6NCE6
    • Q6UX60
    • Q8NC62
    • Q8NCB3
    • Q8NCJ1
    • Q96HP3

    Protein attributes for GLB1L2 Gene

    Size:
    636 amino acids
    Molecular mass:
    72079 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAQ13636.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11149.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for GLB1L2 Gene

Proteomics data for GLB1L2 Gene at MOPED

Selected DME Specific Peptides for GLB1L2 Gene

Post-translational modifications for GLB1L2 Gene

  • Ubiquitination at Lys 165
  • Modification sites at PhosphoSitePlus

Other Protein References for GLB1L2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for GLB1L2 Gene

Suggested Antigen Peptide Sequences for GLB1L2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IW92

UniProtKB/Swiss-Prot:

GLBL2_HUMAN :
  • Belongs to the glycosyl hydrolase 35 family.
Family:
  • Belongs to the glycosyl hydrolase 35 family.
genes like me logo Genes that share domains with GLB1L2: view

No data available for Gene Families for GLB1L2 Gene

Function for GLB1L2 Gene

Enzyme Numbers (IUBMB) for GLB1L2 Gene

genes like me logo Genes that share phenotypes with GLB1L2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GLB1L2

CRISPR Products

No data available for Molecular function , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GLB1L2 Gene

Localization for GLB1L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLB1L2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GLB1L2 Gene COMPARTMENTS Subcellular localization image for GLB1L2 gene
Compartment Confidence
extracellular 4
lysosome 3
vacuole 3
endoplasmic reticulum 2
nucleus 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for GLB1L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with GLB1L2: view

Pathways & Interactions for GLB1L2 Gene

SuperPathways for GLB1L2 Gene

No Data Available

Interacting Proteins for GLB1L2 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000344659%0d%0a9606.ENSP00000282276%0d%0a9606.ENSP00000394051%0d%0a9606.ENSP00000262027%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000344659 for GLB1L2 Gene via STRING

Gene Ontology (GO) - Biological Process for GLB1L2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GLB1L2 Gene

Drugs & Compounds for GLB1L2 Gene

No Compound Related Data Available

Transcripts for GLB1L2 Gene

Unigene Clusters for GLB1L2 Gene

Galactosidase, beta 1-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GLB1L2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20
SP1: - -
SP2: -
SP3:

Relevant External Links for GLB1L2 Gene

GeneLoc Exon Structure for
GLB1L2
ECgene alternative splicing isoforms for
GLB1L2

Expression for GLB1L2 Gene

mRNA expression in normal human tissues for GLB1L2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GLB1L2 Gene

This gene is overexpressed in Colon - Sigmoid (x4.5), Uterus (x4.2), and Prostate (x4.0).

Protein differential expression in normal tissues from HIPED for GLB1L2 Gene

This gene is overexpressed in Lung (62.8) and Retina (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for GLB1L2 Gene



SOURCE GeneReport for Unigene cluster for GLB1L2 Gene Hs.436178

genes like me logo Genes that share expression patterns with GLB1L2: view

Protein tissue co-expression partners for GLB1L2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for GLB1L2 Gene

Orthologs for GLB1L2 Gene

This gene was present in the common ancestor of animals.

Orthologs for GLB1L2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GLB1L2 35
  • 78.44 (n)
  • 75.55 (a)
GLB1L2 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GLB1L2 35
  • 84.15 (n)
  • 83.94 (a)
GLB1L2 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Glb1l2 35
  • 81.47 (n)
  • 79.37 (a)
Glb1l2 16
Glb1l2 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GLB1L2 35
  • 98.95 (n)
  • 98.43 (a)
GLB1L2 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Glb1l2 35
  • 81.21 (n)
  • 78.74 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 66 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia GLB1L2 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves GLB1L2 35
  • 65.35 (n)
  • 64.45 (a)
-- 36
  • 64 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 57 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia glb1l2 35
  • 59.52 (n)
  • 58.61 (a)
African clawed frog
(Xenopus laevis)
Amphibia loc89944-prov 35
zebrafish
(Danio rerio)
Actinopterygii GLB1L2 36
  • 53 (a)
OneToMany
si:dkey-224e22.2 35
  • 59.5 (n)
  • 57.14 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ect3 36
  • 35 (a)
ManyToMany
Gal 36
  • 32 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea H22K11.2 36
  • 29 (a)
ManyToMany
T19B10.3 36
  • 31 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13288 35
Species with no ortholog for GLB1L2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GLB1L2 Gene

ENSEMBL:
Gene Tree for GLB1L2 (if available)
TreeFam:
Gene Tree for GLB1L2 (if available)

Paralogs for GLB1L2 Gene

Paralogs for GLB1L2 Gene

(3) SIMAP similar genes for GLB1L2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GLB1L2: view

Variants for GLB1L2 Gene

Sequence variations from dbSNP and Humsavar for GLB1L2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs544865 -- 134,344,927(+) GAGCC(A/G)TCCCT intron-variant
rs876542 -- 134,374,737(-) CAGGA(A/G)GGGGC intron-variant
rs876543 -- 134,374,532(-) GCATG(C/T)GTGCT intron-variant
rs768570 -- 134,330,805(-) GCGCA(C/G)AGGGA upstream-variant-2KB
rs1042991 -- 134,376,253(+) TTGTT(C/T)TGGGG nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for GLB1L2 Gene

Variant ID Type Subtype PubMed ID
nsv521581 CNV Gain 19592680
nsv832299 CNV Loss 17160897
nsv898475 CNV Gain 21882294
nsv468901 CNV Loss 19166990
nsv469992 CNV Loss 18288195
dgv170n27 CNV Gain 19166990
dgv1326n71 CNV Gain+Loss 21882294
dgv1327n71 CNV Gain 21882294
nsv516459 CNV Gain+Loss 19592680
esv2475970 CNV Deletion 19546169
esv2745325 CNV Deletion 23290073
esv2674216 CNV Deletion 23128226
dgv171n27 CNV Loss 19166990
nsv469993 CNV Gain 18288195
nsv898488 CNV Loss 21882294
nsv898490 CNV Gain 21882294
dgv4e196 CNV Duplication 17116639
nsv521623 CNV Gain 19592680
nsv898491 CNV Gain 21882294
nsv898492 CNV Loss 21882294
nsv826150 CNV Gain 20364138
esv2745327 CNV Deletion 23290073
dgv1328n71 CNV Loss 21882294
nsv561 CNV Insertion 18451855
esv1324855 CNV Insertion 17803354
esv1006179 CNV Insertion 20482838
nsv524977 CNV Loss 19592680
nsv898495 CNV Loss 21882294
nsv898496 CNV Loss 21882294
esv1009565 CNV Deletion 20482838
esv2745328 CNV Deletion 23290073
esv1724782 CNV Deletion 17803354

Variation tolerance for GLB1L2 Gene

Residual Variation Intolerance Score: 77.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.03; 60.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GLB1L2 Gene

HapMap Linkage Disequilibrium report
GLB1L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLB1L2 Gene

Disorders for GLB1L2 Gene

Relevant External Links for GLB1L2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GLB1L2

No disorders were found for GLB1L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GLB1L2 Gene

Publications for GLB1L2 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for GLB1L2 Gene

Sources for GLB1L2 Gene

Back to Top

Content