Aliases for GLA Gene
External Ids for GLA Gene
Previous GeneCards Identifiers for GLA Gene
This gene encodes a homodimeric glycoprotein that hydrolyses the terminal alpha-galactosyl moieties from glycolipids and glycoproteins. This enzyme predominantly hydrolyzes ceramide trihexoside, and it can catalyze the hydrolysis of melibiose into galactose and glucose. A variety of mutations in this gene affect the synthesis, processing, and stability of this enzyme, which causes Fabry disease, a rare lysosomal storage disorder that results from a failure to catabolize alpha-D-galactosyl glycolipid moieties. [provided by RefSeq, Jul 2008]
GeneCards Summary for GLA Gene
GLA (Galactosidase Alpha) is a Protein Coding gene. Diseases associated with GLA include fabry disease and cardiomyopathy, dilated, 1nn. Among its related pathways are Metabolism and Glycosphingolipid biosynthesis - globo series. GO annotations related to this gene include protein homodimerization activity and hydrolase activity. An important paralog of this gene is NAGA.