GLA Gene
protein-coding GIFtS: 68
GCID: GC0XM100652
|
|
galactosidase, alpha
| |
Aliases
for GLA gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Galactosidase, Alpha1 2 | | Alpha-Galactosidase A2 | | GALA1 2 | | Melibiase3 | | Alpha-D-Galactosidase A2 3 | | Agalsidase3 | | EC 3.2.1.223 8 | | Melibiase3 | | Agalsidase Alfa2 | | Alpha-D-Galactoside Galactohydrolase3 | | Alpha-D-Galactoside Galactohydrolase 12 | | EC 3.2.18 | | Alpha-Gal A2 | | |
Export aliases for GLA gene to outside databasesPrevious GC identifers: GC0XM095944 GC0XM097623 GC0XM098688 GC0XM099424 GC0XM100458 GC0XM100539 GC0XM090459 |
Summaries
for GLA gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for GLA:
This gene encodes a homodimeric glycoprotein that hydrolyses the terminal alpha-galactosyl moieties from glycolipidsand glycoproteins. This enzyme predominantly hydrolyzes ceramide trihexoside, and it can catalyze the hydrolysis ofmelibiose into galactose and glucose. A variety of mutations in this gene affect the synthesis, processing, andstability of this enzyme, which causes Fabry disease, a rare lysosomal storage disorder that results from a failure tocatabolize alpha-D-galactosyl glycolipid moieties. (provided by RefSeq, Jul 2008)
Gene Wiki entry for GLA (Alpha-galactosidase)
|
Genomic Views
for GLA gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011651.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the GLA gene promoter:
HOXA9 HOXA9B C/EBPbeta p53 GATA-2 CREB IRF-2 deltaCREB STAT3 Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for GLA
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GLA |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq22 Ensembl cytogenetic band: Xq22.1 HGNC cytogenetic band: Xq21.3-q22GLA Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM100652: view genomic region
(about GC identifiers)
Start:
|
100,652,779 bp from pter |
End:
|
100,663,001 bp from pter |
Size:
|
10,223 bases |
Orientation:
|
minus strand |
|
Proteins
for GLA gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: AGAL_HUMAN, P06280 (See
protein sequence)Recommended Name: Alpha-galactosidase A precursor Size: 429 amino acids; 48767 Da
Subunit: Homodimer
Subcellular location: Lysosome
Rna editing: Modified_positions=396; Note=Partially edited
6/16 PDB 3D structures from  and Proteopedia  for GLA (see all 16):1R46 (3D)
1R47 (3D)
3GXN (3D)
3GXP (3D)
3GXT (3D)
3HG2 (3D)
Explore the universe of human proteins at neXtProt for GLA: NX_P06280
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P06280
3 DME Specific Peptides for GLA (P06280)
GLA Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_000160.1
ENSEMBL proteins: ENSP00000218516 Reactome Protein details: P06280
Human Recombinant Protein Products for GLA:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
GLA for ontologies About GeneDecksing
GLA Antibody Products:
Assay Products for GLA: |
Protein
Domains /
Families
for GLA gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GLA for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P06280ProtoNet protein and cluster: P06280 1 Blocks protein family: IPB002241 Glycosyl hydrolase family 27 signature
UniProtKB/Swiss-Prot: AGAL_HUMAN, P06280Similarity: Belongs to the glycosyl hydrolase 27 family |
Function
for GLA gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: AGAL_HUMAN, P06280Catalytic activity: Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, includinggalactose oligosaccharides, galactomannans and galactolipids Genatlas biochemistry entry for GLA:galactosidase,alpha
Enzyme Numbers (IUBMB): EC 3.2.1.221 2 EC 3.2.12
Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9): About this table
GLA for ontologies About GeneDecksing
Phenotypes:
7 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Gla):
GLA for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Glatm1Kul for GLA
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GLA (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GLA (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: GLA (NM_199173) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GLA | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GLA |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GLA |
|
Pathways & Interactions
for GLA gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Sphingolipid metabolism | | | 2 | Galactose metabolism | | | 3 | Metabolism | | | 4 | Lysosome | | | 5 | Glycerolipid metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for GLA
1  GeneGo (Thomson Reuters) Pathway for GLA
4 
Reactome Pathways for GLA
5 
Kegg Pathways (Kegg details for GLA):
GLA for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GLA
STRING Interaction
Network Preview (showing 5 interactants - click image to see 22)
5/25 Interacting proteins for GLA (P062803 ENSP000002185164) via UniProtKB, MINT, STRING, and/or I2D (see all 25)About this table
Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006644 | phospholipid metabolic process |
TAS | -- | | GO:0006665 | sphingolipid metabolic process |
TAS | -- | | GO:0006687 | glycosphingolipid metabolic process |
TAS | -- | | GO:0009311 | oligosaccharide metabolic process |
IDA | 39940 | | GO:0016139 | glycoside catabolic process |
IBA | -- |
GLA for ontologies About GeneDecksing
|
Drugs & Compounds
for GLA gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
GLA for compounds About GeneDecksing
 Browse Tocris compounds for GLA
UniProtKB/Swiss-Prot: AGAL_HUMAN, P06280Pharmaceutical: Available under the names Replagal (Transkaryotic Therapies) and Fabrazyme (Genzyme). Used as along-term enzyme replacement therapy in patients with a confirmed diagnosis of Fabry disease
10/50 HMDB Compounds for GLA (see all 50) About this table
1 DrugBank Compound for GLA About this table
| Compound | Synonyms |
CAS
# | Type | Actions | PubMed Ids |
|---|
| Alpha-D-Mannose | -- | 3458-28-4 | target | -- | -- |
10/58 Novoseek chemical compound relationships for GLA gene (see all 58) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| ceramidetrihexoside |
88.4 |
3 |
1338214 (1), 10697955 (1) |
| fabrazyme |
87.7 |
1 |
18351385 (1) |
| glycosphingolipid |
83.2 |
15 |
14635108 (1), 1315304 (1), 16805371 (1), 19621417 (1) (see all 14) |
| melibiose |
81.3 |
11 |
1835726 (1), 9058977 (1), 17196483 (1), 1711992 (1) (see all 8) |
| p-nitrophenyl alpha-d-galactopyranoside |
78.6 |
2 |
8948456 (1), 8405947 (1) |
| raffinose |
78.1 |
14 |
1835726 (1), 7671975 (1), 9058977 (1), 17196483 (1) (see all 14) |
| stachyose |
78.1 |
4 |
7671975 (1), 18834998 (1), 1651679 (1), 10570815 (1) |
| gamma-carboxyglutamic acid |
75.9 |
47 |
1498334 (6), 8135347 (4), 17347154 (3), 10668405 (3) (see all 11) |
| galactose |
73.7 |
33 |
8386150 (2), 7575533 (2), 15136043 (2), 2106074 (1) (see all 21) |
| globotriosylceramide |
69.4 |
2 |
8039705 (1), 1886355 (1) |
Search CenterWatch for drugs/clinical trials and news about GLA / AGAL
|
Transcripts
for GLA gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for GLA gene: NM_000169.2 Unigene Cluster for GLA: Galactosidase, alpha Hs.69089 [show with all ESTs]Unigene Representative Sequence: NM_0001697 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000493905 ENST00000218516(uc004ehl.1) ENST00000466414 ENST00000468823
ENST00000480513 ENST00000486121 ENST00000479445(uc011mrj.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GLA (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GLA (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: GLA (NM_199173) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GLA | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GLA |
Additional cDNA sequence: AK222627.1 AK291095.1 AK297148.1 BC002689.2 BT006864.1 D00039.1 X05790.1 X16889.1 13 DOTS entries: DT.452710 DT.100882792 DT.121284708 DT.95375140 DT.121284616 DT.100882790 DT.121284614 DT.95311268 DT.95375138 DT.101984472 DT.121284594 DT.91812055 DT.95375136 24/212 AceView cDNA sequences (see all 212): CD366940 BU191867 CR617861 CB528859 CD366587 BM722327 CD365034 CD366650 CN480771 CD364682 BU681392 AW517319 CB529635 AW731746 CR607242 CD365189 BT006864 BQ934640 NM_000169 CB528519 CD365200 BM450649 BU615633 BE855462
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for GLA (see all 8) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7a | · | 7b | ^ | 8a | · | 8b |
|---|
|
| SP1: | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | - | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | - | | | | | | | |
ECgene alternative splicing isoforms for GLA
|
Expression
for GLA gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| GLA expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTAATGACC
About this image
See GLA Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GLA
SOURCE GeneReport for Unigene cluster: Hs.69089
SABiosciences Expression via Pathway-Focused PCR Array including GLA: | Nitric Oxide Signaling Pathway in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GLA
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GLA | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GLA | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GLA | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GLA |
Orthologs
for GLA gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for GLA gene from 8/27 species (see all 27) About this table
ENSEMBL Gene Tree for GLA (if available)
TreeFam Gene Tree for GLA (if available) |
Paralogs
for GLA gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for GLA gene
- NAGA2
2 SIMAP similar genes for GLA using alignment to 2 protein entries: AGAL_HUMAN (see all proteins):alpha-GalA NAGA
GLA for paralogs About GeneDecksing
|
Genomic Variants
for GLA gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for GLA (100652779 - 100663001 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for GLA: --
Human Gene Mutation Database (HGMD): GLA
Locus Specific Mutation Databases (LSDB): GLA
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GLA |
|
Disorders
/ Diseases
for GLA gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
GLA for disorders About GeneDecksing
OMIM gene information: 300644
OMIM disorders: 301500
UniProtKB/Swiss-Prot: AGAL_HUMAN, P06280
Defects in GLA are the cause of Fabry disease (FD) [MIM:301500]. FD is a rare X-linked sphingolipidosisdisease where glycolipid accumulates in many tissues. The disease consists of an inborn error of glycosphingolipidcatabolism. FD patients show systemic accumulation of globotriaoslyceramide (Gb3) and related glycosphingolipids inthe plasma and cellular lysosomes throughout the body. Clinical recognition in males results from characteristic skinlesions (angiokeratomas) over the lower trunk. Patients may show ocular deposits, febrile episodes, and burning painin the extremities. Death results from renal failure, cardiac or cerebral complications of hypertension or othervascular disease. Heterozygous females may exhibit the disorder in an attenuated form, they are more likely to showcorneal opacities
20/64  diseases for GLA (see all 64): About MalaCardsfabry disease tay-sachs disease fabry disease, cardiac variant gangliosidosis gm1
cramp-fasciculations syndrome lysosomal storage disease atypical variants of fabry disease mucopolysaccharidosis vii
classic fabry disease gangliosidosis clostridium difficile anhidrosis
glycogen storage disease schindler disease autonomic dysfunction sickle cell disease
keutel syndrome kanzaki disease sphingolipidosis x inactivation
6 diseases from the University of Copenhagen DISEASES database for GLA:Fabry disease Angiokeratoma Hypohidrosis X-linked disease
Kidney failure Proteinuria 10/27 Novoseek disease relationships for GLA gene (see all 27) About this table
Genatlas disease: GLA diffuse angiokeratoderma,Fabry disease,typical and atypical
GeneTests: GLA
Fabry Disease
Genetic Association Database (GAD): GLA
Human Genome Epidemiology (HuGE) Navigator: GLA (30 documents)
Export disorders for GLA gene to outside databases
|
Publications
for GLA gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for GLA gene, integrated from 9 sources (see all 398):
(articles sorted by number of sources associating them with GLA) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Newborn screening for Fabry disease in Taiwan reveals a high incidence of the later-onset GLA mutation c.936+919G>A (IVS4+919G> ;A). (PubMed id 19621417)1, 2, 9 Hwu W.L....Hsu L.W. (2009)
- Thirty-four novel mutations of the GLA gene in 121 patients with Fabry disease. (PubMed id 15776423)1, 4, 9 Schafer E....Gal A. (2005)
- Sixty-nine kilobases of contiguous human genomic sequence containing the alpha-galactosidase A and Bruton's tyrosine kinase loci. (PubMed id 7626884)1, 2, 9 Oeltjen J.C....Gibbs R.A. (1995)
- Detection of alpha-galactosidase a mutations causing Fabry disease by denaturing high performance liquid chromatography. (PubMed id 15712228)1, 2, 9 Shabbeer J....Desnick R.J. (2005)
- Galactose stabilizes various missense mutants of alpha-galactosidase in Fabry disease. (PubMed id 7575533)1, 2, 9 Okumiya T....Suzuki Y. (1995)
- Identification of a novel de novo mutation (G373D) in the alpha- galactosidase A gene (GLA) in a patient affected with Fabry disease. (PubMed id 11295840)1, 2, 9 Germain D.P.... Poenaru L. (2001)
- Fabry disease: identification of novel alpha-galactosidase A mutations and molecular carrier detection by use of fluorescent chemical cleavage of mismatches. (PubMed id 10208848)1, 2, 9 Germain D.P. and Poenaru L. (1999)
- Editing of human alpha-galactosidase RNA resulting in a pyrimidine to purine conversion. (PubMed id 7503918)1, 2, 9 Novo F.J.... Gorecki D.C. (1995)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- The molecular defect leading to Fabry disease: structure of human alpha-galactosidase. (PubMed id 15003450)1, 2 Garman S.C. and Garboczi D.N. (2004)
|
External Searches for GLA gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing GLA gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing GLA gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GLA gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for GLA | Pharmacogenomics, SNPs, Pathways | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/GLA |
|
| | |
About This Section
| Patent Information for GLA gene:
Search GeneIP for patents involving GLA
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for GLA gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
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| | |  | OriGene Antibodies for GLA | | OriGene shRNA RFP for GLA | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GLA | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GLA | | | OriGene Protein Over-expression Lysate for GLA | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for GLA | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GLA | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GLA | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for GLA | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for GLA | | OriGene Custom Protein Services for GLA | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GLA | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GLA | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GLA | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GLA | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GLA | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GLA |
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| | | | Search Tocris compounds for GLA |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GLA |
|  |  |  |  | | | | ThermoFisher Antibodies for GLA |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GLA |
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